Abstract Objective: To correlate the nasal anatomical characteristics of newborns with the dimensions of short binasal prongs. Method: Observational, cross-sectional study carried out in two hospitals in southern Brazil. The authors evaluated 1620 newborns with neonatal data and nasal dimensions. To measure the dimensions of the nasal region, the authors considered the width of the medial columella, the right nostril diameter, and the left nostril diameter. These data were correlated with the dimensions of two models of short binasal prongs. Results: Of the total newborns evaluated, 807 were female (49.8%), and 813 were male (50.2%). The majority were white (96.2%). The mean gestational age was 37.4 ± 2.9 weeks, ranging from 22 to 42 weeks. The birth weight was 2946.8 ± 699.3 g, ranging from 490.0 to 4740.0 g. Most of the nasal measures were significantly larger than both prong model measurements. Conclusion: The sizes of short binasal prongs available on the Brazilian market do not match the nasal anatomical characteristics of newborns. Objective Method Observational crosssectional cross sectional Brazil 162 region columella diameter Results 80 49.8%, 498 49.8% , 49 8 (49.8%) 81 50.2%. 502 50.2% . 50 2 (50.2%) 96.2%. 962 96.2% 96 (96.2%) 374 37 4 37. 29 9 2. weeks 29468 2946 2946. 6993 699 3 699. g 4900 490 0 490. 47400 4740 4740. measurements Conclusion 16 49.8 (49.8% 50.2 5 (50.2% 96.2 (96.2% 294 69 474 1 49. (49.8 50. (50.2 96. (96.2 6 47 (49. (50. (96. (49 (50 (96 (4 (5 (9 (

The aim of this work was to extract and characterize pectin from lyophilized noni pulp (Morinda citrifolia Linn.) at three different pHs using different extractor agents and to evaluate anti-viral activity. The extraction of high yield (acid extraction) was subjected to sulfation procedure. Fourier transform infrared spectroscopy and proton nuclear magneticresonance analysis were used to calculate the degree of methylation of pectin from acid extraction and its sulfated derivative. The data obtained for the degree of methylation of noni pectin and sulfated pectin were 30.3 and 30.7, respectively. Pectin was subjected to acute oral toxicity testing in mice. The results showed that pectin had a pro-inflammatory effect, and sulfated pectin had an anti-inflammatory effect. Both pectins were also evaluated for herpes simplex virus activity in vitro, and although they successfully inhibited virus replication, the sulfated pectins were cytotoxic. Morinda Linn. Linn antiviral anti viral procedure derivative 303 30 3 30. 307 7 30.7 respectively mice proinflammatory pro inflammatory effect antiinflammatory vitro replication cytotoxic

RESUMEN Objetivo: Analizar la prevalencia y los factores asociados a causas externas en ancianos atendidos por el servicio de atención móvil de urgencia. Método: Estudio transversal con 1.972 registros de atención pre hospitalaria de ancianos víctimas de causas externas en el período de 2019 a 2020.Se realizó un análisis descriptivo y bivariado, con un nivel de significación del 5% (p<0,05). Resultados: La prevalencia de causas externas en adultos mayores atendidos por el servicio de emergencia móvil fue de 12,2%. La caída fue la ocurrencia más frecuente. Se destacaron las asociaciones de la ocurrencia de caídas con la edad a partir de 90 años (OR=29,31; p<0,001) y el género femenino (OR=5,38; p<0,001), así como la sospecha de ingesta de bebidas alcohólicas con la ocurrencia de violencia (OR=4,17; p<0,001) y accidentes de tránsito (OR=1,97; p<0,001). Conclusión: El estudio mostró factores asociados a las lesiones por causas externas en ancianos y puede apoyar la formulación de estrategias de enfrentamiento de este problema. Objetivo urgencia Método 1972 1 972 1.97 201 2020Se 2020 bivariado 5 p<0,05. p005 p p<0,05 . 0 05 (p<0,05) Resultados 122 12 2 12,2% frecuente 9 OR=29,31 OR2931 OR 29 31 (OR=29,31 p<0,001 p0001 001 OR=5,38 OR538 38 (OR=5,38 p<0,001, , OR=4,17 OR417 4 17 (OR=4,17 OR=1,97 OR197 97 (OR=1,97 p<0,001. Conclusión problema 197 1.9 20 202 p00 p<0,0 (p<0,05 12,2 OR=29,3 OR293 3 (OR=29,3 p<0,00 p000 00 OR=5,3 OR53 (OR=5,3 OR=4,1 OR41 (OR=4,1 OR=1,9 OR19 (OR=1,9 19 1. p0 p<0, (p<0,0 12, OR=29, OR29 (OR=29, OR=5, OR5 (OR=5, OR=4, OR4 (OR=4, OR=1, OR1 (OR=1, p<0 (p<0, OR=29 OR2 (OR=29 OR=5 (OR=5 OR=4 (OR=4 OR=1 (OR=1 p< (p<0 OR=2 (OR=2 OR= (OR= (p< (OR (p

ABSTRACT Objective: To analyze the prevalence and factors associated with external causes in elderly people attended by the mobile emergency care service. Method: Cross-sectional study with 1,972 pre-hospital care records of elderly victims of external causes from 2019 to 2020. A descriptive and bivariate analysis was performed, with a significance level of 5% (p<0.05). Results: The prevalence of external causes in elderly people attended by the mobile emergency service was 12.2%. Falling was the most frequent occurrence. The associations of the occurrence of falls with age from 90 years old (OR=29.31; p<0.001) and female gender (OR=5.38; p<0.001) stood out, as well as the suspicion of ingestion of alcoholic beverages with occurrence of violence (OR=4.17; p<0.001) and traffic accidents (OR=1.97; p<0.001). Conclusion: The study showed factors associated with injuries due to external causes in theelderly and may support the formulation of coping strategies for this problem. Objective Method Crosssectional Cross sectional 1972 1 972 1,97 prehospital pre hospital 201 2020 performed 5 p<0.05. p005 p p<0.05 . 0 05 (p<0.05) Results 122 12 2 12.2% 9 OR=29.31 OR2931 OR 29 31 (OR=29.31 p<0.001 p0001 001 OR=5.38 OR538 38 (OR=5.38 out OR=4.17 OR417 4 17 (OR=4.17 OR=1.97 OR197 97 (OR=1.97 p<0.001. Conclusion problem 197 1,9 20 202 p00 p<0.0 (p<0.05 12.2 OR=29.3 OR293 3 (OR=29.3 p<0.00 p000 00 OR=5.3 OR53 (OR=5.3 OR=4.1 OR41 (OR=4.1 OR=1.9 OR19 (OR=1.9 19 1, p0 p<0. (p<0.0 12. OR=29. OR29 (OR=29. OR=5. OR5 (OR=5. OR=4. OR4 (OR=4. OR=1. OR1 (OR=1. p<0 (p<0. OR=29 OR2 (OR=29 OR=5 (OR=5 OR=4 (OR=4 OR=1 (OR=1 p< (p<0 OR=2 (OR=2 OR= (OR= (p< (OR (p

RESUMO Objetivo: Analisar a prevalência e fatores associados a causas externas em idosos atendidos pelo serviço de atendimento móvel de urgência. Método: Estudo transversal com 1.972 fichas de atendimento pré-hospitalar de idosos vítimas de causas externas no período de 2019 a 2020. Realizou-se análise descritiva e bivariada, com nível de significância de 5% (p<0,05). Resultados: A prevalência de causas externas em idosos atendidos pelo serviço móvel de urgência foi de 12,2%. A queda foi a ocorrência mais frequente. Destacaram-se as associações da ocorrência de queda com a idade a partir de 90 anos (OR=29,31; p<0,001) e o sexo feminino (OR=5,38; p<0,001), bem como da suspeita de ingestão de bebida alcoólica com a ocorrência de violência (OR=4,17; p<0,001) e acidentes de trânsito (OR=1,97; p<0,001). Conclusão: O estudo evidenciou fatores associados aos agravos por causas externas em idosos e poderá subsidiar formulação de estratégias de enfrentamento a essa problemática. Objetivo Método 1972 1 972 1.97 préhospitalar pré hospitalar 201 2020 Realizouse Realizou se bivariada 5 p<0,05. p005 p p<0,05 . 0 05 (p<0,05) Resultados 122 12 2 12,2% frequente Destacaramse Destacaram 9 OR=29,31 OR2931 OR 29 31 (OR=29,31 p<0,001 p0001 001 OR=5,38 OR538 38 (OR=5,38 p<0,001, , OR=4,17 OR417 4 17 (OR=4,17 OR=1,97 OR197 97 (OR=1,97 p<0,001. Conclusão problemática 197 1.9 20 202 p00 p<0,0 (p<0,05 12,2 OR=29,3 OR293 3 (OR=29,3 p<0,00 p000 00 OR=5,3 OR53 (OR=5,3 OR=4,1 OR41 (OR=4,1 OR=1,9 OR19 (OR=1,9 19 1. p0 p<0, (p<0,0 12, OR=29, OR29 (OR=29, OR=5, OR5 (OR=5, OR=4, OR4 (OR=4, OR=1, OR1 (OR=1, p<0 (p<0, OR=29 OR2 (OR=29 OR=5 (OR=5 OR=4 (OR=4 OR=1 (OR=1 p< (p<0 OR=2 (OR=2 OR= (OR= (p< (OR (p

Abstract Difficult airway management in pediatrics during anesthesia represents a major challenge, requiring a careful approach, advanced technical expertise, and accurate protocols. The task force of the Brazilian Society of Anesthesiology (SBA) presents a report containing updated recommendations for the management of difficult airways in children and neonates. These recommendations have been developed based on the consensus of a panel of experts, with the objective of offering strategies to overcome challenges during airway management in pediatric patients. Grounded in evidence published in international guidelines and expert opinions, the report highlights crucial steps for the appropriate management of difficult airways in pediatrics, encompassing assessment, preparation, positioning, pre-oxygenation, minimizing trauma, and, paramountly, the maintenance of arterial oxygenation. The report also delves into additional strategies involving the use of advanced tools, such as video laryngoscopy, flexible intubating bronchoscopy, and supraglottic devices. Emphasis is placed on the simplicity of implementing the outlined recommendations, with a focus on the significance of continuous education, training through realistic simulations, and familiarity with the latest available technologies. These practices are deemed essential to ensure procedural safety and contribute to the enhancement of anesthesia outcomes in pediatrics. challenge approach expertise protocols SBA (SBA neonates experts patients opinions assessment preparation positioning preoxygenation, preoxygenation pre oxygenation, oxygenation pre-oxygenation trauma paramountly tools laryngoscopy bronchoscopy devices education simulations technologies

ABSTRACT This study aimed to investigate the effects of xylanase (Xyl) individually or in combination with B. subtilis and B. licheniformis associated or not with yeast cell wall in pig diets with a reduction of 100 kcal/kg of metabolizable energy (ME) content. Pig performance, bone parameters, intestinal morphometry, and bioeconomic indices were evaluated. A total of 75 pigs (25 females and 50 barrows; 25.02±3.21 kg) obtained from crossing Large White × Landrace were used. The experimental design consisted of randomized blocks, with five treatments and five blocks, totaling 25 experimental units subjected to treatments: basal diet (B); basal diet with reduction of 100 kcal/kg of ME (BEM); BEM with supplementation of xylanase (0.01%; BX); BX with supplementation of direct-fed microbials (composed of B. subtilis and B. licheniformis; 0.02%; BXM); and BX supplemented with 0.10% of symbiotic (which includes B. subtilis, B. licheniformis, and yeast cell wall; BXS). There were no differences in bone parameters. The BEM diet resulted in a lower villus height:crypt depth ratio in the jejunum than that seen upon using the BXS diet as feed. In the first period, pigs fed BEM diet had a 12% higher average daily feed intake than those fed the BXM diet. There were no differences in the pig performance during the second period. Over the total period, pigs fed BEM diet had greater FCR compared with pigs fed BXM diet. The inclusion of feed additives in diets with reduced ME content contributes to the maintenance of performance and characteristics of the metacarpus and jejunum of growing pigs and provides better bioeconomic indices. Xyl (Xyl B 10 kcalkg kcal kg (ME parameters morphometry evaluated 7 (2 5 barrows 2502321 02 3 21 25.02±3.2 used blocks 2 (B) (BEM) 0.01% 001 0 01 (0.01% BX) directfed direct composed 0.02% 002 BXM) 010 0.10 which BXS. . BXS) heightcrypt height crypt period 12 1 ( 250232 25.02±3. (B (BEM 0.01 00 (0.01 0.02 0.1 25023 25.02±3 0.0 (0.0 0. 2502 25.02± (0. 250 25.02 (0 25.0 25.

Abstract The study, carried out from May 2022 to April 2023, aimed to discuss the teaching of integrality in the Multiprofessional Residency Program in Family Health Strategy, based on the experience of residents of Belém, Pará, Brazil. The research adopted a cross-sectional approach with a quantitative and qualitative approach and data collection carried out by a semi-structured questionnaire with five axes of interest: sociodemographic data, previous knowledge, and knowledge about the principle of integrality, inclusion of integrality in the theoretical activities of the program, articulation of theoretical knowledge with professional practice and applicability of integrality in the health actions carried out by the professional teams. 29 residents of nursing, physiotherapy, dentistry and occupational therapy regularly enrolled in the program participated. The findings revealed that the participants recognize the importance of integrality in meeting users’ health needs, pointing out that the integral approach must be validated and legitimized as an inseparable part of care. But the learning of integrality still constitutes a conceptual and methodological challenge, a reality that needs to be evaluated in the planning and choice of strategies for health education. It is concluded that the teaching of residents should prioritize the approach of this principle in more depth, to favor a more meaningful and powerful learning. study 202 2023 Strategy Belém Pará Brazil crosssectional cross sectional semistructured semi structured interest teams 2 nursing physiotherapy participated users care challenge education depth 20

Resumen El estudio, realizado de mayo de 2022 a abril de 2023, tuvo como objetivo discutir la enseñanza de la integralidad en el Programa de Residencia Multiprofesional en Estrategia de Salud de la Familia, a partir de la experiencia de residentes en Belém, Pará, Brasil. La investigación adoptó un abordaje transversal con enfoque cuantitativo y cualitativo y recolección de datos mediante cuestionario semiestructurado con cinco ejes de interés: datos sociodemográficos, conocimientos previos y sobre el principio de la integralidad, inclusión de la integralidad en las actividades teóricas del programa, articulación de los conocimientos teóricos con la práctica profesional y aplicabilidad de la integralidad en las acciones de salud realizadas por los equipos profesionales. Participaron 29 residentes de enfermería, fisioterapia, odontología y terapia ocupacional inscritos regularmente en el programa. Los resultados revelaron que los participantes reconocen la importancia de la integralidad para satisfacer las necesidades de salud de los usuarios, señalando que el enfoque integral debe ser validado y legitimado como parte inseparable de la atención. Sin embargo, el aprendizaje de la integralidad sigue siendo un reto conceptual y metodológico, una realidad que debe valorarse a la hora de planificar y elegir estrategias para la docencia en salud. Se concluye que los residentes de enseñanza deben priorizar el tratamiento de este principio en mayor profundidad, a fin de promover un aprendizaje más significativo y eficaz. estudio 202 2023 Familia Belém Pará Brasil interés sociodemográficos programa profesionales 2 enfermería fisioterapia usuarios atención embargo metodológico profundidad eficaz 20

Resumo O estudo, realizado de maio de 2022 a abril de 2023, teve o objetivo de discutir o ensino da integralidade no Programa de Residência Multiprofissional em Estratégia Saúde da Família, com base na experiência de residentes de Belém, no Pará. A pesquisa adotou recorte transversal com abordagem quantiqualitativa e coleta de dados realizada por um questionário semiestruturado com cinco eixos de interesse: dados sociodemográficos, conhecimentos e saberes prévios sobre o princípio da integralidade, inclusão da integralidade nas atividades teóricas do programa, articulação dos conhecimentos teóricos com a prática profissional e aplicabilidade da integralidade nas ações de saúde realizadas pelas equipes profissionais. Participaram 29 residentes de enfermagem, fisioterapia, odontologia e terapia ocupacional regularmente matriculados no programa. Os achados revelaram que os participantes reconhecem a importância da integralidade no atendimento das necessidades em saúde dos usuários, apontando que a abordagem integral deve ser validada e legitimada como parte indissociável do cuidado. Mas o aprendizado da integralidade ainda constitui um desafio conceitual e metodológico, realidade que precisa ser avaliada no planejamento e na escolha das estratégias para o ensino em saúde. Conclui-se que o ensino dos residentes deve priorizar a abordagem desse princípio com mais profundidade, para favorecer um aprendizado mais significativo e potente. estudo 202 2023 Família Belém Pará interesse sociodemográficos programa profissionais 2 enfermagem fisioterapia usuários cuidado metodológico Concluise Conclui se profundidade potente 20

ABSTRACT Purpose To characterize the communicative acts of children with Developmental Language Disorder, verifying the number of communicative acts, interactive communicative acts, and their relationship with chronological age. Methods Forty children of both sexes with a diagnosis of Developmental Language Disorder aged between 3 years and seven years and 11 months were subjects. All subjects were assessed with the ABFW Pragmatics Test - Child Language Test in their initial assessment. Specifically, this study focused on verifying the number of communicative acts, communicative acts per minute, interactive communicative acts, and the number of communicative initiatives. Results The data indicate that children with Developmental Language Disorder present significant alterations concerning communicative acts and communicative interactions, and there is a correlation between these variables and chronological age. Conclusion Children with Developmental Language Disorder show a decrease in the number of communicative acts, interactive communicative acts, and communicative interactions when compared to the reference values of typical children, regardless of age. age 1 assessment Specifically minute initiatives

RESUMO Objetivo Caracterizar os atos comunicativos de crianças com transtorno do desenvolvimento da linguagem, verificando a quantidade de atos comunicativos, atos comunicativos interativos e sua relação com a idade cronológica. Métodos Foram participantes 40 crianças de ambos os gêneros com diagnóstico de transtorno do desenvolvimento da linguagem com idades entre 3 anos e 2 meses e 7 anos e 11 meses. Todos os sujeitos foram avaliados com a Prova de Pragmática ABFW - Teste de Linguagem Infantil, em sua avaliação inicial. Especificamente para este estudo, focou-se na verificação da quantidade de atos comunicativos, atos comunicativos por minuto, atos comunicativos interativos e número de iniciativas comunicativas. Resultados Os dados indicaram que crianças com transtorno do desenvolvimento da linguagem apresentam alterações importantes em relação aos atos comunicativos e interações comunicativas e há correlação dessas variáveis com a idade cronológica. Conclusão Crianças com transtorno do desenvolvimento da linguagem apresentam diminuição no número de atos comunicativos, atos comunicativos interativos e interações comunicativas, quando comparadas aos valores de referência de crianças típicas, independentemente da idade. cronológica 4 1 Infantil inicial estudo focouse focou se minuto típicas

Abstract Chives are one of the most popular spice plants in world cuisine. It is usually produced by small producers, often in an organic farming system. However, research with chives in this production system is lacking. The purpose of this study was to evaluate the production of chives with the use of organic fertilizers before planting and in top dressing. Seven treatments were evaluated, resulting from the factorial 2x3+1, with two organic fertilizers (castor bean cake and hoof and horn powder) x 3 application modes (100% before planting; 100% in top dressing; 50% before planting and 50% in top dressing) + 1 control (without these organic fertilizers). The experimental design was in randomized blocks, with five replications and plots of 1 m2. The relative index of chlorophyll (“Spad” index), height, number of leaves, fresh and dry weight of the plants were evaluated. All treatments of the factorial were better than the control, showing that these organic fertilizers improve production in chives. It is recommended to use the hoof and horn powder in installments (50% before planting and 50% in top dressing) or 100% in top dressing, the latter option being more interesting for reducing the need for labor, with just one application moment. cuisine producers However lacking dressing evaluated 2x31 2x3 2x3+1 castor 100 (100 50 without fertilizers. . fertilizers) blocks m2 m Spad (“Spad index, , index) height leaves (50 labor moment 2x 2x3+ 10 (10 5 (5 (1 (

ABSTRACT Backgrounds: Fortunately, much has been studied about COVID-19 in patients with inflammatory bowel diseases (IBD). Evidence suggests that these patients do not appear to be at increased risk of severe COVID-19. However, there are still some uncertainties regarding the clinical manifestations of COVID-19 in patients with immune-mediated diseases. Objective: This study aimed to describe the main symptoms of COVID-19 and their frequency in IBD patients and evaluate the impact of the IBD therapeutic drugs on clinical presentation of COVID-19 and to determine factors associated with COVID-19 in this population. Methods: Adult patients with IBD from three tertiary-care public, teaching hospitals in Ceará, Northeastern Brazil, were evaluated during one scheduled appointment from March to December 2020. Patients with possible or confirmed COVID-19 were compared with patients without COVID-19. Furthermore, incidences of each symptom were evaluated based on the use of IBD therapeutic drugs. Results: A total of 515 patients with IBD were included in the study: 234 with CD, and 281 with UC. Of these, 174 patients (34%) had possible/confirmed COVID-19 of whom 156 (90%) were symptomatic. Main symptoms were fever (65%) and headache (65%); gastrointestinal symptoms occurred in one third of patients and were higher than COVID-19 in general population. The factors associated with having COVID-19 were female gender (OR 1.71, 95%CI: 1.17-2.50); contact at home (OR 5.07, 95%CI: 3.31-7.78) and outside the home (OR 3.14, 95%CI: 2.10-4.71) with a case of COVID-19; work outside of the home (OR 1.87, 95%CI: 1.26-2.78); family history of COVID-19 (OR 2.29, 95%CI 1.58-3.33) use of salicylate (OR 1.71, 95%CI: 1.17-4.28); and asthma (OR 7.10, 95%CI: 1.46-34.57). Conclusion: IBD patients at high risk of COVID-19 infection may need to avoid salicylate therapy but further studies are necessary to confirm this association. Backgrounds Fortunately COVID19 COVID 19 COVID-1 IBD. . (IBD) COVID19. 19. However immunemediated immune mediated Objective population Methods tertiarycare tertiary care public Ceará Brazil 2020 Furthermore Results 51 23 CD 28 UC 17 34% 34 (34% possibleconfirmed 15 90% 90 (90% symptomatic 65% 65 (65% OR 171 1 71 1.71 95CI CI 95 1.172.50 117250 1.17 2.50 2 50 1.17-2.50) 507 5 07 5.07 3.317.78 331778 3.31 7.78 3 31 7 78 3.31-7.78 314 14 3.14 2.104.71 210471 2.10 4.71 10 4 2.10-4.71 187 87 1.87 1.262.78 126278 1.26 2.78 26 1.26-2.78) 229 29 2.29 1.583.33 158333 1.58 3.33 58 33 1.58-3.33 1.174.28 117428 4.28 1.17-4.28) 710 7.10 1.4634.57. 1463457 1.46 34.57 46 57 1.46-34.57) Conclusion association COVID1 COVID- (IBD 202 (34 9 (90 6 (65 1.7 172 1.172.5 11725 117 1.1 250 2.5 1.17-2.50 0 5.0 317 3.317.7 33177 331 3.3 778 7.7 3.31-7.7 3.1 104 2.104.7 21047 210 2.1 471 4.7 2.10-4.7 18 8 1.8 262 1.262.7 12627 126 1.2 278 2.7 1.26-2.78 22 2.2 583 1.583.3 15833 158 1.5 333 1.58-3.3 1.174.2 11742 428 4.2 1.17-4.28 7.1 4634 1.4634.57 146345 146 1.4 3457 34.5 1.46-34.57 20 (3 (9 (6 1. 1.172. 1172 11 25 2. 1.17-2.5 5. 3.317. 3317 3. 77 7. 3.31-7. 2.104. 2104 21 47 4. 2.10-4. 1.262. 1262 12 27 1.26-2.7 1.583. 1583 1.58-3. 1.174. 1174 42 1.17-4.2 463 1.4634.5 14634 345 34. 1.46-34.5 ( 1.172 1.17-2. 3.317 3.31-7 2.104 2.10-4 1.262 1.26-2. 1.583 1.58-3 1.174 1.17-4. 1.4634. 1463 1.46-34. 1.17-2 3.31- 2.10- 1.26-2 1.58- 1.17-4 1.4634 1.46-34 1.17- 1.26- 1.463 1.46-3 1.46-

RESUMO Contexto: Felizmente, muito se tem estudado sobre a COVID-19 em pacientes com doenças inflamatórias intestinais (DII). As evidências sugerem que esses pacientes não parecem ter risco aumentado de COVID-19 grave. Mas ainda se tem algumas incertezas com relação às manifestações clínicas da COVID-19 em portadores de doenças imunomediadas. Objetivo: Este estudo teve como objetivo descrever os principais sintomas da COVID-19 e sua frequência em pacientes com DII e avaliar o impacto dos medicamentos utilizados no tratamento das DII na apresentação clínica da COVID-19. Métodos: Pacientes adultos com DII de três hospitais públicos terciários de ensino do Ceará, Nordeste do Brasil, foram avaliados em consulta ambulatorial no período de março a dezembro de 2020. Pacientes com COVID-19 possível ou confirmada foram comparados com pacientes sem COVID-19. Além disso, as incidências de cada sintoma foram avaliadas com base no uso de medicamentos utilizados para tratamento da DII. Resultados: Foram incluídos no estudo 515 pacientes com DII: 234 com DC e 281 com RCU. Destes, 174 pacientes (34%) tinham COVID-19 possível/confirmado, dos quais 156 (90%) eram sintomáticos. Os principais sintomas foram febre (65%) e dor de cabeça (65%); sintomas gastrointestinais ocorreram em um terço dos pacientes, sendo mais frequentes do que na população geral com COVID-19. Os fatores associados a ter COVID-19 foram sexo feminino (OR 1,71, IC95%: 1,17-2,50); ter contato com caso de COVID-19, tanto intradomiciliar (OR 5,07; IC95%: 3,31-7,78) como fora do domicílio (OR 3,14; IC95%: 2,10-4,71); trabalhar fora de casa (OR 1,87; IC95%: 1,26-2,78); história familiar de COVID-19 (OR 2,29, IC95% 1,58-3,33), uso de salicilato (OR 1,71, IC95%: 1,17-4,28) e asma (OR 7,10; IC95%: 1,46-34,57). Conclusão: Pacientes com DII com alto risco de infecção por COVID-19 podem precisar evitar a terapia com salicilatos, mas mais estudos são necessários para confirmar esta associação. Contexto Felizmente COVID19 COVID 19 COVID-1 . (DII) grave imunomediadas Objetivo COVID19. 19. Métodos Ceará Brasil 2020 disso Resultados 51 23 28 RCU Destes 17 34% 34 (34% possívelconfirmado confirmado possível/confirmado 15 90% 90 (90% sintomáticos 65% 65 (65% OR 171 1 71 1,71 IC95 IC 1,172,50 117250 1,17 2,50 2 50 1,17-2,50) COVID19, 19, 5,07 507 5 07 3,317,78 331778 3,31 7,78 3 31 7 78 3,31-7,78 3,14 314 14 2,104,71 210471 2,10 4,71 10 4 2,10-4,71) 1,87 187 87 1,262,78 126278 1,26 2,78 26 1,26-2,78) 229 29 2,29 1,583,33, 158333 1,58 3,33 , 58 33 1,58-3,33) 1,174,28 117428 4,28 1,17-4,28 7,10 710 1,4634,57. 1463457 1,46 34,57 46 57 1,46-34,57) Conclusão salicilatos associação COVID1 COVID- (DII 202 (34 9 (90 6 (65 1,7 IC9 172 1,172,5 11725 117 1,1 250 2,5 1,17-2,50 5,0 0 317 3,317,7 33177 331 3,3 778 7,7 3,31-7,7 3,1 104 2,104,7 21047 210 2,1 471 4,7 2,10-4,71 1,8 18 8 262 1,262,7 12627 126 1,2 278 2,7 1,26-2,78 22 2,2 583 1,583,33 15833 158 1,5 333 1,58-3,33 1,174,2 11742 428 4,2 1,17-4,2 7,1 4634 1,4634,57 146345 146 1,4 3457 34,5 1,46-34,57 20 (3 (9 (6 1, 1,172, 1172 11 25 2, 1,17-2,5 5, 3,317, 3317 3, 77 7, 3,31-7, 2,104, 2104 21 47 4, 2,10-4,7 1,262, 1262 12 27 1,26-2,7 1,583,3 1583 1,58-3,3 1,174, 1174 42 1,17-4, 463 1,4634,5 14634 345 34, 1,46-34,5 ( 1,172 1,17-2, 3,317 3,31-7 2,104 2,10-4, 1,262 1,26-2, 1,583, 1,58-3, 1,174 1,17-4 1,4634, 1463 1,46-34, 1,17-2 3,31- 2,10-4 1,26-2 1,583 1,58-3 1,17- 1,4634 1,46-34 2,10- 1,26- 1,58- 1,463 1,46-3 1,46-

Abstract Objective To map and synthetize evidence on forensic nursing care for adult men victims of sexual violence. Methods A scoping review in accordance with JBI method. The eligibility criteria included: Population - adult men aged 18 to 59 years old; Concept - forensic nursing care; and Context - sexual violence against an adult man treated in health services. The search was carried out in three stages by two researchers, with the participation of a third reviewer to solve doubts. Data collection was carried out from data sources using descriptors and keywords. For this review, the temporal and idiomatic cut-off was not updated. The Virtual Health Library (VHL), Nursing Database (BDENF), Medical Literature Analysis and Retrieval System Online (MEDLINE) via PubMed, CINAHL via Ebsco databases and gray literature were used. Data were systematically spread sheeted, and inductive content analysis was carried out on 16 included studies. Synthesis of results was presented using charts, infographics and diagrams. Results It focused on compassionate care and helping relationship, subjective data recording, need to remove the victim’s clothes, head-foot examination, injury recording on body diagrams, photographic records, forensic trace collection and preservation, oropharyngeal collection, penile, scrotal and anorectal swabs. Care related to colposcopy, use of Wood’s lamp and anoscopy was mapped. Conclusion Situations of sexual violence against men, although little addressed, can occur frequently in everyday life, which implies the recognition of care that can promote welcoming in order to preserve their integrity and reduce trauma arising from this situation as well as guaranteeing forensic trace recording. method 1 5 old services researchers doubts keywords cutoff cut off updated VHL, VHL , (VHL) BDENF, BDENF (BDENF) MEDLINE (MEDLINE PubMed used sheeted studies charts diagrams relationship victim s clothes headfoot head foot examination records preservation penile swabs colposcopy Woods Wood mapped addressed life (VHL (BDENF

Resumen Objetivo Mapear y sintetizar evidencias sobre la atención de enfermería forense a hombres adultos víctimas de violencia sexual. Métodos Scoping review de acuerdo con el método JBI. Los criterios de elegibilidad incluyeron: población (hombres adultos entre 18 y 59 años), concepto (atención de enfermería forense) y contexto (violencia sexual contra hombres adultos atendidos en servicios de salud). La búsqueda fue realizada en tres etapas por dos investigadores, con la participación de un tercer revisor para aclarar dudas. La recopilación de datos se llevó a cabo a partir de fuentes de datos, mediante descriptores y palabras clave. Para esta revisión, no se actualizó el corte temporal e idiomático. Se utilizaron las siguientes bases de datos: Biblioteca Virtual en Salud (BVS), Banco de Datos de Enfermería (BDENF), Medical Literature Analysis and Retrieval System Online (MEDLINE) vía PubMed, CINAHL vía Ebsco y literatura gris. Los datos se difundieron sistemáticamente y se realizó un análisis inductivo en los 16 estudios incluidos. La síntesis de los resultados se presentó por medio de gráficos, infográficos y diagramas. Resultados Se centró en el cuidado compasivo y en la relación de ayuda, el registro de datos subjetivos, la necesidad de remoción de ropa de la víctima, examen de cabeza y pies, registro de lesiones en diagramas corporales, registros fotográficos, recopilación y preservación de vestigios forenses, toma de muestras orofaríngeas, hisopados peneanos, escrotales y anorrectales. Se mapearon los cuidados relacionados con la colposcopía, el uso de la lámpara de Wood y la anoscopía. Conclusión Situaciones de violencia sexual contra hombres, a pesar de ser poco abordadas, pueden ocurrir con frecuencia en la vida cotidiana, lo que implica el reconocimiento de cuidados que puedan promover la acogida, a fin de preservar su integridad y reducir traumas resultantes de esta situación, además de garantizar el registro del rastreo forense. JBI incluyeron 1 5 años, años , años) salud. salud . salud) investigadores dudas clave revisión idiomático BVS, BVS (BVS) BDENF, BDENF (BDENF) MEDLINE (MEDLINE PubMed gris incluidos gráficos ayuda subjetivos víctima pies corporales fotográficos forenses orofaríngeas peneanos anorrectales colposcopía anoscopía abordadas cotidiana acogida situación (BVS (BDENF

Resumo Objetivo Mapear e sintetizar evidências sobre a assistência de enfermagem forense a homens adultos vítimas de violência sexual. Métodos Scoping review de acordo com o método JBI. Os critérios de elegibilidade incluíram: População – homens adultos com idade entre 18 e 59 anos; Conceito – assistência de enfermagem forense; e Contexto – violência sexual contra homem adulto atendido em serviços de saúde. A busca foi realizada em três etapas por dois pesquisadores, com a participação de um terceiro revisor para sanar dúvidas. A coleta de dados foi realizada a partir de fontes de dados por meio de descritores e palavras-chave. Para esta revisão, o corte temporal e idiomático não foi atualizado. Foram utilizadas as bases de dados Biblioteca Virtual em Saúde (BVS), Base de Dados de Enfermagem (BDENF), Medical Literature Analysis and Retrieval System Online (MEDLINE) via PubMed, CINAHL via Ebsco e literatura cinzenta. Os dados foram sistematicamente divulgados e foi realizada análise de conteúdo indutiva em 16 estudos incluídos. A síntese dos resultados foi apresentada por meio de gráficos, infográficos e diagramas. Resultados Centrou-se no cuidado compassivo e na relação de ajuda, registro de dados subjetivos, necessidade de retirada da roupa da vítima, exame de cabeça e pés, registro de lesões em diagramas corporais, registros fotográficos, coleta e preservação de vestígios forenses, coleta de orofaringe, swabs penianos, escrotais e anorretais. Foram mapeados cuidados relacionados à colposcopia, ao uso da lâmpada de Wood e à anuscopia. Conclusão Situações de violência sexual contra homens, embora pouco abordadas, podem ocorrer com frequência no cotidiano, o que implica o reconhecimento de cuidados que possam promover o acolhimento, a fim de preservar sua integridade e reduzir traumas decorrentes dessa situação, bem como garantir o registro do rastreio forense. JBI incluíram 1 5 anos saúde pesquisadores dúvidas palavraschave. palavraschave palavras chave. chave palavras-chave revisão atualizado BVS, BVS , (BVS) BDENF, BDENF (BDENF) MEDLINE (MEDLINE PubMed cinzenta incluídos gráficos Centrouse Centrou se ajuda subjetivos vítima pés corporais fotográficos forenses orofaringe penianos anorretais colposcopia anuscopia abordadas cotidiano acolhimento situação (BVS (BDENF

ABSTRACT Objective: To understand the perception of nurses who work in the School Health Program about mental health in children and adolescents. Method: This was a qualitative, exploratory, and descriptive study carried out between December 2022 and February 2023, with nurses working in Family Health Strategies in a municipality on the western border of Rio Grande do Sul - Brazil. Data collection with semi-structured interviews and Minayo’s Thematic Analysis. Results: The concept of mental health was linked to both the traditional concept and the expanded clinic. The risk factors for the mental health of children and adolescents highlighted were family conflicts, prejudice, exposure to violence, digital influence, the use of psychoactive substances, and crime. Conclusion: There is a need to promote care strategies, especially for nurses, enabling them to take a more critical look at risk factors and mental health demands based on the specific characteristics of children and adolescents. Objective Method qualitative exploratory 202 2023 Brazil semistructured semi structured Minayos Minayo s Analysis Results clinic conflicts prejudice violence influence substances crime Conclusion strategies 20 2

RESUMO Objetivo: Conhecer a percepção de enfermeiros que atuam no Programa Saúde na Escola acerca da saúde mental infantojuvenil. Método: Pesquisa qualitativa, exploratória e descritiva realizada entre dezembro de 2022 a fevereiro de 2023, com enfermeiros atuantes em Estratégias Saúde da Família no município da Fronteira Oeste do Rio Grande do Sul - Brasil. Coleta dos dados com entrevistas semiestruturadas e Análise Temática de Minayo. Resultados: A concepção de saúde mental esteve atrelada tanto ao conceito tradicional quanto à clínica ampliada. Os fatores de risco à saúde mental das crianças e adolescentes destacados foram conflitos familiares, preconceito, exposição a violências, influência digital, uso de substâncias psicoativas e criminalidade. Conclusão: Destaca-se a necessidade de fomento às estratégias de cuidado, especialmente por parte dos enfermeiros, capacitando-os para realizarem um olhar mais crítico e centrado nos fatores de risco e nas demandas em saúde mental, de acordo com as especificidades do público infantojuvenil. Objetivo infantojuvenil Método qualitativa 202 2023 Brasil Minayo Resultados ampliada familiares preconceito violências digital criminalidade Conclusão Destacase Destaca se cuidado capacitandoos capacitando os 20 2

RESUMEN Objetivo: Conocer la percepción de enfermeros que trabajan en el Programa de Salud Escolar sobre la salud mental en niños y jóvenes. Método: Estudio cualitativo, exploratorio y descriptivo realizado entre diciembre de 2022 y febrero de 2023, con enfermeros que trabajan en Estrategias de Salud de la Familia en el municipio de Fronteira Oeste do Rio Grande do Sul - Brasil. Recogida de datos con entrevistas semiestructuradas y Análisis Temático de Minayo. Resultados: TEl concepto de salud mental estaba vinculado tanto al concepto tradicional como a la clínica ampliada. Los factores de riesgo para la salud mental de los niños y adolescentes destacados fueron los conflictos familiares, los prejuicios, la exposición a la violencia, la influencia digital, el consumo de sustancias psicoactivas y la delincuencia. Conclusión: Es necesario promover estrategias de atención, especialmente por parte de los enfermeros, que les permitan tener una visión más crítica de los factores de riesgo y de las demandas de salud mental, de acuerdo con las características específicas de los niños y los jóvenes. Objetivo jóvenes Método cualitativo 202 2023 Brasil Minayo Resultados ampliada familiares prejuicios violencia digital delincuencia Conclusión atención 20 2

Abstract The study evaluated the use of nano copper in semi-purified diets for laying quails and its effect on performance, metabolic state, and bioavailability. A total of 160 (180-days-old) quails were distributed in a completely randomized design, in a 3x3+1 factorial. The copper sources used were copper sulfate, copper oxide, and nano copper oxide, at levels of 200, 400, and 800 ppm each, totaling nine treatments plus a negative control (with no copper inclusion). The following variables were determined: weight gain, feed intake, egg production, egg weight, hemoglobin, hematocrit, Cu in the tissues and Cu bioavailability. Data were subjected to analysis of variance at 5% probability. The effect of sources and levels, as well as the interaction between the factors were evaluated. When interaction was observed, the effect of sources was evaluated separately by the Tukey’s test and the effect of levels by regression, both at 5% probability. Copper nano oxide can be used at up to 800 ppm in the diet of laying quails without altering the productive performance, and with higher bioavailability than conventional copper oxide. Hemoglobin increases with the inclusion of 200 and 400 ppm of nano copper oxide and the hematocrit with 400 ppm. semipurified semi purified performance state 16 180daysold daysold 180 days old (180-days-old design 3x31 x 3x3 1 3x3+ factorial sulfate 80 each inclusion. . inclusion) determined gain intake production hemoglobin 5 probability observed Tukeys Tukey s regression 20 40 18 3x 8 2 4

This study investigated the efficiency of the natural anticorrosive coating of propolis extract (PE) on CA-50 carbon steel in a solution that simulates the liquid phase of the concrete pore condition, called cement extract (CE). Fourier transform infrared (FTIR) and high-performance liquid chromatography (HPLC) analyses of the propolis extract identified inhibitory functional groups, with Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) being the predominant component present in the propolis extract (PE). To examine the inhibition capacity of propolis extract on reinforcement, an aqueous solution of 3.5 wt.% NaCl solution was added to the cement extract in the presence and absence of PE. Electrochemical techniques such as open circuit potential, polarization curves and electrochemical impedance spectroscopy were carried out to study corrosion efficiency. Scanning electron microscopy (SEM) was performed to characterize the sample surface. The results show that PE was effective as an anti-corrosion coating for carbon steel in the environment studied, indicating the formation of a protective film with higher stability. (PE CA50 CA 50 CA-5 condition CE. CE . (CE) FTIR (FTIR highperformance high performance HPLC (HPLC groups 3,5diprenyl4hydroxycinnamic 35diprenyl4hydroxycinnamic diprenylhydroxycinnamic 3,5 diprenyl 4 hydroxycinnamic 3 5 acid reinforcement 35 3. wt wt. potential SEM (SEM surface anticorrosion anti studied stability CA5 CA- (CE 5diprenyl4hydroxycinnamic 3,

Abstract Objective To develop the second evidence-based Brazilian Society of Rheumatology consensus for diagnosis and treatment of lupus nephritis (LN). Methods Two methodologists and 20 rheumatologists from Lupus Comittee of Brazilian Society of Rheumatology participate in the development of this guideline. Fourteen PICO questions were defined and a systematic review was performed. Eligible randomized controlled trials were analyzed regarding complete renal remission, partial renal remission, serum creatinine, proteinuria, serum creatinine doubling, progression to end-stage renal disease, renal relapse, and severe adverse events (infections and mortality). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to develop these recommendations. Recommendations required ≥82% of agreement among the voting members and were classified as strongly in favor, weakly in favor, conditional, weakly against or strongly against a particular intervention. Other aspects of LN management (diagnosis, general principles of treatment, treatment of comorbidities and refractory cases) were evaluated through literature review and expert opinion. Results All SLE patients should undergo creatinine and urinalysis tests to assess renal involvement. Kidney biopsy is considered the gold standard for diagnosing LN but, if it is not available or there is a contraindication to the procedure, therapeutic decisions should be based on clinical and laboratory parameters. Fourteen recommendations were developed. Target Renal response (TRR) was defined as improvement or maintenance of renal function (±10% at baseline of treatment) combined with a decrease in 24-h proteinuria or 24-h UPCR of 25% at 3 months, a decrease of 50% at 6 months, and proteinuria < 0.8 g/24 h at 12 months. Hydroxychloroquine should be prescribed to all SLE patients, except in cases of contraindication. Glucocorticoids should be used at the lowest dose and for the minimal necessary period. In class III or IV (±V), mycophenolate (MMF), cyclophosphamide, MMF plus tacrolimus (TAC), MMF plus belimumab or TAC can be used as induction therapy. For maintenance therapy, MMF or azathioprine (AZA) are the first choice and TAC or cyclosporin or leflunomide can be used in patients who cannot use MMF or AZA. Rituximab can be prescribed in cases of refractory disease. In cases of failure in achieving TRR, it is important to assess adherence, immunosuppressant dosage, adjuvant therapy, comorbidities, and consider biopsy/rebiopsy. Conclusion This consensus provides evidence-based data to guide LN diagnosis and treatment, supporting the development of public and supplementary health policies in Brazil. evidencebased evidence LN. . (LN) 2 guideline performed remission doubling endstage end stage disease relapse infections mortality. mortality mortality) Assessment GRADE (GRADE 82 ≥82 favor conditional intervention diagnosis, (diagnosis opinion involvement but procedure parameters developed TRR (TRR ±10% 10 (±10 24h 24 25 months 50 08 0 8 0. g24 g g/2 1 period ±V, V ±V , (±V) MMF, (MMF) cyclophosphamide TAC, (TAC) therapy AZA (AZA adherence dosage biopsyrebiopsy rebiopsy biopsy/rebiopsy Brazil (LN ≥8 ±10 (±1 5 g2 g/ (±V (MMF (TAC ≥ ±1 (± ± (

ABSTRACT Background Ventilator-associated tracheobronchitis is a common condition among invasively ventilated patients in intensive care units, for which the best treatment strategy is currently unknown. We designed the VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) trial to assess whether a watchful waiting antibiotic treatment strategy is noninferior to routine antibiotic treatment for ventilator-associated tracheobronchitis regarding days free of mechanical ventilation. Methods VATICAN is a randomized, controlled, open-label, multicenter noninferiority trial. Patients with suspected ventilator-associated tracheobronchitis without evidence of ventilator-associated pneumonia or hemodynamic instability due to probable infection will be assigned to either a watchful waiting strategy, without antimicrobial administration for ventilator-associated tracheobronchitis and prescription of antimicrobials only in cases of ventilator-associated pneumonia, sepsis or septic shock, or another infectious diagnosis, or to a routine antimicrobial treatment strategy for seven days. The primary outcome will be mechanical ventilation-free days at 28 days, and a key secondary outcome will be ventilator-associated pneumonia-free survival. Through an intention-to-treat framework with a per-protocol sensitivity analysis, the primary outcome analysis will address noninferiority with a 20% margin, which translates to a 1.5 difference in ventilator-free days. Other analyses will follow a superiority analysis framework. Conclusion The VATICAN trial will follow all national and international ethical standards. We aim to publish the trial in a high-visibility general journal and present it at critical care and infectious disease conferences for dissemination. These results will likely be immediately applicable to the bedside upon trial completion and will provide information with a low risk of bias for guideline development. Ventilatorassociated Ventilator associated units unknown VentilatorAssociated Associated Evaluation ventilatorassociated ventilator ventilation randomized controlled openlabel, openlabel open label, label open-label shock diagnosis ventilationfree 2 pneumoniafree survival intentiontotreat intention treat perprotocol per protocol 20 margin 15 1 5 1. ventilatorfree standards highvisibility high visibility dissemination development

RESUMO Contexto A traqueobronquite associada ao ventilador é uma condição comum entre pacientes ventilados invasivamente em unidades de terapia intensiva, para a qual se desconhece atualmente a melhor estratégia de tratamento. Desenhamos o estudo VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) para avaliar se uma estratégia de tratamento antibiótico de espera vigilante não é inferior ao tratamento antibiótico de rotina para traqueobronquite associada ao ventilador em relação aos dias sem ventilador mecânico. Métodos O VATICAN é um estudo randomizado, controlado, aberto e multicêntrico de não inferioridade. Os pacientes com suspeita de traqueobronquite associada ao ventilador sem evidência de pneumonia associada ao ventilador ou instabilidade hemodinâmica devido a uma provável infecção serão designados para uma estratégia de espera vigilante, sem administração profilática de antimicrobianos contra traqueobronquite associada ao ventilador e prescrição de antimicrobianos somente em casos de pneumonia associada ao ventilador, sepse ou choque séptico, ou outro diagnóstico infeccioso, ou para uma estratégia de tratamento antimicrobiano de rotina por 7 dias. O desfecho primário será o número de dias sem ventilador mecânico em 28 dias, e um desfecho secundário importante será a sobrevida sem pneumonia associada ao ventilador. Por meio de uma estrutura de intenção de tratar com análise de sensibilidade por protocolo, a análise do desfecho primário abordará a não inferioridade com margem de 20%, o que se traduz em uma diferença de 1,5 dia sem ventilador. Outras análises seguirão uma estrutura de análise de superioridade. Conclusão O VATICAN seguirá todos os padrões éticos nacionais e internacionais. O objetivo é publicar o estudo em um periódico geral de alta visibilidade e apresentá-lo em conferências de cuidados intensivos e doenças infecciosas para divulgação. Estes resultados provavelmente serão imediatamente aplicáveis à beira do leito após a conclusão do estudo e fornecerão informações com baixo risco de viés para o desenvolvimento de diretrizes. intensiva VentilatorAssociated Ventilator Associated Evaluation randomizado controlado séptico infeccioso 2 protocolo 20 20% 15 1 5 1, superioridade internacionais apresentálo apresentá lo divulgação diretrizes