ABSTRACT Purpose: This study aimed to determine whether early-stage intraocular pressure can be modulated using a thermal face mask. Methods: In this prospective clinical study, healthy participants were randomized on a 1:1:1 allocation ratio to three mask groups: hypothermic (G1), normothermic (G2), and hyperthermic (G3). After randomization, 108 eyes from 108 participants were submitted to clinical evaluations, including measurement of initial intraocular pressure (T1). The thermal mask was then applied for 10 minutes, followed by a second evaluation of intraocular pressure (T2) and assessment of any side effects. Results: The hypothermic group (G1) showed a significant reduction in mean intraocular pressure between T1 (16.97 ± 2.59 mmHg) and T2 (14.97 ± 2.44 mmHg) (p<0.001). G2 showed no significant pressure difference between T1 (16.50 ± 2.55 mmHg) and T2 (17.00 ± 2.29 mmHg) (p=0.054). G3 showed a significant increase in pressure from T1 (16.53 ± 2.69 mmHg) to T2 (18.58 ± 2.95 mmHg) (p<0.001). At T1, there was no difference between the three study groups (p=0.823), but at T2, the mean values of G3 were significantly higher than those of G1 and G2 (p<0.00). Conclusion: Temperature was shown to significantly modify intraocular pressure. Thermal masks allow the application of temperature in a controlled, reproducible manner. Further studies are needed to assess the duration of these effects and whether they are reproducible in patients with pathologies that affect intraocular pressure. Purpose earlystage early stage Methods 111 1 1:1: G1, G , G2, (G2) G3. . (G3) randomization evaluations T1. T (T1) minutes (T2 Results (G1 16.97 1697 16 97 (16.9 259 2 59 2.5 mmHg 14.97 1497 14 (14.9 244 44 2.4 p<0.001. p0001 p p<0.001 0 001 (p<0.001) 16.50 1650 50 (16.5 255 55 17.00 1700 17 00 (17.0 229 29 2.2 p=0.054. p0054 p=0.054 054 (p=0.054) 16.53 1653 53 269 69 2.6 18.58 1858 18 58 (18.5 295 95 2.9 p=0.823, p0823 p=0.823 823 (p=0.823) p<0.00. p000 p<0.00 (p<0.00) Conclusion controlled manner 11 1:1 (G2 (G3 (T1 (T (G 16.9 169 9 (16. 25 5 2. 14.9 149 (14. 24 4 (p<0.001 16.5 165 17.0 170 (17. 22 p005 p=0.05 05 (p=0.054 26 6 18.5 185 (18. p082 p=0.82 82 (p=0.823 p00 p<0.0 (p<0.00 1: 16. (16 14. (14 17. (17 p=0.0 (p=0.05 18. (18 p08 p=0.8 8 (p=0.82 p0 p<0. (p<0.0 (1 p=0. (p=0.0 (p=0.8 p<0 (p<0. ( p=0 (p=0. p< (p<0 p= (p=0 (p< (p= (p

ABSTRACT Unvaccinated identical twins developed bilateral anterior uveitis soon after the onset of coronavirus disease 2019 symptoms. During follow-up, both patients developed choroiditis, and one twine developed posterior scleritis and serous retinal detachment. Prompt treatment with oral prednisone ameliorated the lesions, and no recurrence was observed at the 18-month follow-up. Choroiditis may rarely be associated with severe acute respiratory syndrome coronavirus 2 infection, and it responds well to corticosteroid therapy. Although the exact mechanism is unknown, we hypothesize that the virus may act as an immunological trigger for choroiditis. 201 symptoms followup, followup follow up, up follow-up choroiditis detachment lesions 18month month 18 followup. up. infection therapy unknown 20 1

Resumo A produção de tintas utilizando resíduos de beneficiamento de granito e mármore é uma nova alternativa para contribuir com o desenvolvimento sustentável na construção civil. Entretanto, a carência de estudos sobre a composição e o desempenho dessas tintas inviabiliza a disseminação desse novo material de construção. Logo, este estudo tem como objetivo investigar a composição dessas tintas utilizando ferramentas estatísticas para obter produtos com desempenho compatível com regulamentações técnicas e tintas comerciais. As formulações de tintas foram definidas através de um planejamento de misturas quaternárias. O teor de sólidos, pH, viscosidade, poder de cobertura e resistência à abrasão foram determinados para todas as amostras. As tintas produzidas com resíduos de granito apresentaram melhor poder de cobertura e resistência à abrasão, pois o resíduo de granito apresenta granulometria mais fina, além de ser predominantemente composto por sílica. Por fim, as tintas produzidas neste estudo e as tintas comerciais apresentaram comportamento semelhante, o que corrobora com o aproveitamento do resíduo do processamento de rochas ornamentais na produção de tintas. civil Entretanto Logo quaternárias sólidos pH viscosidade amostras fina sílica fim semelhante

Abstract The production of paints using waste from granite and marble processing is a new alternative to contribute to sustainable development in civil construction. However, the lack of studies on the composition and performance of these paints makes the dissemination of this new construction material unfeasible. Therefore, this study aims to investigate the composition of these paints using statistical tools to obtain products with performance compatible with technical regulations and commercial paints. The paint formulations were defined through a quaternary mixture planning. The solids content, pH, viscosity, hiding power, and abrasion resistance were determined for all samples. The paints produced with granite waste showed better hiding power and abrasion resistance, as granite waste has a finer granulometry, in addition to being predominantly composed of silica. Finally, the paints produced in this study and the commercial paints showed similar behavior, which supports the use of waste from the processing of ornamental rocks in paint production. However unfeasible Therefore planning content pH viscosity samples granulometry silica Finally behavior

Resumen Contexto: El Consejo de Enfermería es una Intervención que reúne un conjunto de contenidos específicos y una estructura determinada, teniendo en cuenta los conocimientos científicos. La Enfermera Especialista en Salud Mental y Psiquiatría (EESMP) proporciona cuidados de apoyo, permitiendo a las mujeres embarazadas hacer frente a los cambios emocionales asociados al embarazo. Objetivo: Crear un programa de asesoramiento de enfermería en salud mental perinatal. Metodología: Estudio cualitativo, exploratorio y descriptivo mediante Scoping Review y Focus Group. Resultados: Programa aplicado en atención primaria, a partir de las 20 semanas de embarazo. Se celebraron sesiones individuales presenciales o un formato híbrido (inicial, final y de seguimiento) y sesiones de asesoramiento en grupo (con un máximo de ocho a diez participantes), en las que se trataron los siguientes temas: Promoción de la salud mental perinatal; Estrategias para el bienestar; Afrontamiento del puerperio. Conclusiones: El programa demostró la importancia de la enfermería de salud mental perinatal en la promoción de la salud de las mujeres y la contribución del EESMP a la formación, el cambio de comportamiento y la alfabetización en este periodo tan específico del ciclo vital.

Abstract Background: Nursing Counselling is an Intervention that brings together a set of specific contents and a certain structure, taking scientific knowledge into account. The Mental Health and Psychiatric Nurse Specialist (MHPSS) provides supportive care, enabling pregnant women to cope with the emotional changes associated with pregnancy. Aim: To create a perinatal mental health nursing counselling programme. Methods: A qualitative, exploratory and descriptive study using a Scoping review and Focus Group. Results: Programme implemented in primary healthcare, starting at 20 weeks of pregnancy. Individual face-to-face sessions or a hybrid format (initial, final and follow-up) and group counselling sessions (maximum eight to 10 participants) were held, covering the following topics: Perinatal Mental Health Promotion; Strategies for well-being; Coping with the postpartum period. Conclusions: The programme demonstrated the importance of perinatal mental health nursing in promoting women's health and the contribution of the MHPSS to training, behaviour change and literacy in this very specific period of the life cycle.

Resumo Contexto: O Aconselhamento em Enfermagem é uma Intervenção que reúne um conjunto de conteúdos próprios e uma determinada estrutura, tendo em conta o conhecimento científico. O Enfermeiro Especialista Enfermagem Saúde Mental e Psiquiátrica (EEESMP) presta cuidados de apoio e suporte, permitindo a capacitação das grávidas para lidar com as mudanças emocionais associadas à gravidez. Objetivo: Criar programa de aconselhamento em enfermagem de saúde mental perinatal. Metodologia: Estudo qualitativo, exploratório e descritivo através da scoping review e Focus Group. Resultados: Programa implementado nos cuidados de saúde primários, a iniciar-se a partir das 20 semanas de gravidez. Realizadas sessões individuais presenciais e ou formato híbrido (inicial, final e follow-up) e por sessões de aconselhamento em grupo (máximo oito a 10 participantes) em que foram abordadas as temáticas: Promoção da Saúde Mental Perinatal; Estratégias para o bem-estar; Lidar com o pós-parto. Conclusões: O Programa demostrou a importância da Enfermagem de Saúde Mental Perinatal na promoção da saúde da mulher e o contributo do EEESMP na capacitação, na mudança de comportamento e na literacia neste período tão específico do ciclo vital.

Resumen Introducción: El sufrimiento psicológico entre adolescentes y estrategias para la promoción de la salud mental existe y es necesario. Objetivo: Caracterizar las demandas emocionales de adolescentes escolares y describir conocimientos sobre factores protectores de la salud mental. Métodos: Investigación sociopoética con 30 adolescentes. Resultados: Temas de análisis: “Cuestiones de interés sobre emociones y salud mental”; “Cómo afrontar el estrés y la ansiedad”; “Reflexiones sobre la resolución de conflictos y problemas enfrentados”; y “Conocimiento sobre factores protectores de la salud mental”. Conclusiones: Las actividades recreativas y artísticas son poderosas para la promoción de la salud mental de los adolescentes y pueden implementarse a través de la asociación escuela-servicio de salud.

Abstract Introduction: Psychological suffering among adolescents and strategies for the promotion of mental health exists and is necessary. Aim: To characterize the emotional demands of school adolescents and describe knowledge about protective factors of mental health. Methods: Sociopoetic research with 30 adolescents. Results/Analysis topics: “Questions of interest about emotions and mental health”; “Dealing with stress and anxiety”; “Reflections on conflict resolution and problems faced”; and “Knowledge about protective factors of mental health”. Conclusions: Recreational and artistic activities are powerful for the promotion of adolescent mental health, and can be implemented through the school-health service partnership.

Resumo Introdução: O sofrimento psicológico entre adolescentes e estratégias para a promoção da saúde mental existem e são necessários. Objetivo: Caracterizar as demandas emocionais de adolescentes escolares e descrever o conhecimento sobre fatores protetores da saúde mental. Métodos: Pesquisa sociopoética com 30 adolescentes. Resultados: Temas de análise: “Questões de interesse sobre emoções e saúde mental”; “Lidar com o stresse e a ansiedade”; “Reflexões sobre resolução de conflitos e problemas enfrentados”; e “Conhecimento sobre fatores de proteção da saúde mental”. Conclusões: As atividades recreativas e artísticas são potentes para a promoção da saúde mental dos adolescentes e podem ser implementadas através da parceria escola/serviço de saúde.

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura &gt; 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (&gt; 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.&nbsp;&nbsp; Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor &gt; 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (&gt; 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness &gt; 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (&gt; 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

Background: The concept introduced by enhanced recovery after surgery protocols modifies perioperative traditional care in digestive surgery. The integration of these modern recommendations components during the perioperative period are highly important to ensure less postoperative complications, reduced length of hospital stay and decreased surgical costs. Aims: The aim of this position paper is to emphasize the most important points of a multimodal perioperative care protocol. Methods:&nbsp; A careful analysis of each recommendation of both ERAS and ACERTO protocols is presented, justifying its inclusion in the recommended multimodal care of digestive surgery patients. Results: Enhanced recovery programs (ERPs) such as ERAS and ACERTO protocols are a cornerstone in modern perioperative care. Nutritional therapy is highly important in digestive surgery and thus both preoperative and postoperative nutrition care are key to ensure less postoperative complications and to reduce the length of hospital stay. The concept of prehabilitation is another key element in ERPs. Management of crystalloid fluids in a perfect balance in vital. Fluid overload may delay the recovery of patients and increase postoperative complications. Abbreviation of preoperative fast for 2h before anesthesia is now accepted by various guidelines of both surgical and anesthesiology societies. Combined with early postoperative refeeding, these prescriptions are not only safe but can also enhance recovery of patients undergoing digestive procedures. Conclusions: This Brazilian College of Digestive Surgery position paper strongly emphasizes that the implementation of ERPs in digestive surgery represents a paradigm shift in perioperative care, transcending traditional practices and embracing an intelligent approach to patient well-being. &nbsp; Background: The concept introduced by enhanced recovery after surgery protocols modifies perioperative traditional care in digestive surgery. The integration of these modern recommendations components during the perioperative period are highly important to ensure less postoperative complications, reduced length of hospital stay and decreased surgical costs. Aims: The aim of this position paper is to emphasize the most important points of a multimodal perioperative care protocol. Methods:&nbsp; A careful analysis of each recommendation of both ERAS and ACERTO protocols is presented, justifying its inclusion in the recommended multimodal care of digestive surgery patients. Results: Enhanced recovery programs (ERPs) such as ERAS and ACERTO protocols are a cornerstone in modern perioperative care. Nutritional therapy is highly important in digestive surgery and thus both preoperative and postoperative nutrition care are key to ensure less postoperative complications and to reduce the length of hospital stay. The concept of prehabilitation is another key element in ERPs. Management of crystalloid fluids in a perfect balance in vital. Fluid overload may delay the recovery of patients and increase postoperative complications. Abbreviation of preoperative fast for 2h before anesthesia is now accepted by various guidelines of both surgical and anesthesiology societies. Combined with early postoperative refeeding, these prescriptions are not only safe but can also enhance recovery of patients undergoing digestive procedures. Conclusions: This Brazilian College of Digestive Surgery position paper strongly emphasizes that the implementation of ERPs in digestive surgery represents a paradigm shift in perioperative care, transcending traditional practices and embracing an intelligent approach to patient well-being.

ABSTRACT: When applied at growing phase, lighting program aims to obtain quails with body weight and physiological maturity suitable for the beginning of laying. This study evaluated lighting programs at growing phase on performance, sexual maturity and egg quality of meat quail breeders (Coturnixcoturnix) at laying phase. From 7 to 49 days of age, 300 female meat quails were subjected to three lighting programs (natural, intermittent and continuous), with 5 replicates of 20 birds each. At 49 days of age, 240 quails were transferred to a shed, maintaining the same experimental conditions. Meat quails submitted to continuous and intermittent lighting programs had higher weight of reproductive system and lower ages for first egg production and to reach 50% of egg production (P < 0.05). Quails submitted to natural lighting had lower feed intake from 49 to 70 and 71 to 92 days of age and worse feed conversion up to 114 days of age. Continuous and intermittent lighting programs resulted in more precocious quails compared to natural lighting program. Quails submitted to natural lighting at growing phase presented lower egg production during all periods, not differing for birds submitted to continuous and intermittent programs from the second period (71 to 92 days of age). Intermittent and continuous lighting result in better feed conversion of breeding quails up to 114 days and a higher percentage of laying (49 to 136 days), reducing the number of days to produce the first egg and to reach 50% of laying, in relation to natural lighting. ABSTRACT performance Coturnixcoturnix (Coturnixcoturnix 4 30 natural, (natural continuous, , continuous) 2 each 24 shed conditions 50 P 0.05. 005 0.05 . 0 05 0.05) 9 11 periods (7 age) (4 13 days, days) 3 00 0.0 1 ( 0.

RESUMO: Quando aplicado na fase de crescimento, o programa de luz visa obter codornas com peso corporal e maturidade fisiológica adequados para o início da postura. Este estudo avaliou programas de iluminação na fase de crescimento sobre o desempenho, maturidade sexual e qualidade dos ovos de codornas de corte reprodutoras (Coturnix coturnix) na fase de postura. Durante o período de sete a 49 dias de idade, 300 codornas de corte fêmeas foram submetidas a três programas de iluminação (natural, intermitente e contínuo), com cinco repetições de 20 aves cada. Aos 49 dias de idade, 240 codornas foram transferidas para um galpão, mantendo a mesma distribuição experimental e submetidas às mesmas condições. As aves submetidas aos programas de iluminação contínuo e intermitente na fase de crescimento apresentaram maiores peso relativo do sistema reprodutivo e consequentemente menores idades para produção do primeiro ovo e para atingir 50% da produção de ovos (P < 0.05). As aves que receberam apenas iluminação natural apresentaram menor consumo de ração nos períodos de 49 a 70 e 71 a 92 dias de idade e pior conversão alimentar até 114 dias de idade. Os programas de iluminação contínua e intermitente na fase de crescimento resultaram em codornas mais precoces quando comparados as aves submetidas ao programa de iluminação natural. Codornas submetidas a programa de luz natural na fase de crescimento apresentaram menor produção de ovos durante todos os períodos, não diferindo das aves submetidas a programas contínuos e intermitentes a partir do segundo período (71 a 92 dias de idade). A iluminação intermitente e contínua na fase de crescimento resulta em melhor conversão alimentar de codornas reprodutoras até 114 dias e maior percentual de postura (49 a 136 dias), reduzindo o número de dias para produzir o primeiro ovo e atingir 50% de postura, em relação a iluminação natural.. RESUMO desempenho Coturnix coturnix 4 30 natural, (natural contínuo, , contínuo) 2 cada 24 galpão condições 50 P 0.05. 005 0.05 . 0 05 0.05) 7 9 11 (7 idade) (4 13 dias, dias) 3 5 00 0.0 1 ( 0.

ABSTRACT BACKGROUND: Nutritional status and growth curves can affect cognitive development, increase the risk of infection, and contribute to the development of chronic diseases. Its etiology is related to food, socioeconomic, and maternal conditions. However, to date, no data on these parameters exist in the state of Goiás, Brazil. OBJECTIVE: To compare the nutritional status and growth curves of children and adolescents in the city of Goiânia, Goiás, Brazil. DESIGN AND SETTING: This was a cross-sectional study. A total of 529 individuals were recruited from a primary health center in the municipality. METHODS: To assess nutritional status, the sample was divided into three categories: 3–4, 5–10, and 11–19 years, with z-score classification considering body mass index for age. The classification of growth curves was performed considering the median height values for age, assuming two references: (a) young Brazilian population and (b) one recommended for international use. The independent sample T-test was used to compare anthropometric variables. RESULTS: The results showed that the classification of eutrophics represents a predominant percentage between both sexes (men: 03–04 = 55.4%; 05–10 = 57.6%; 11–19 = 53.5 % and women: 03–04 = 53.5%; 05–10 = 63.9%; 11–19 = 56.9%), and growth curves showed differences in specific periods in both sexes. CONCLUSIONS: It can be concluded that children and adolescents from the city of Goiânia present as predominance the eutrophic nutritional status, followed by the risk of overweight, underweight, obesity, and malnutrition of both sexes. BACKGROUND infection diseases food socioeconomic conditions However date Goiás Brazil OBJECTIVE SETTING crosssectional cross sectional study 52 municipality METHODS categories 34 3 4 3–4 510 5 10 5–10 1119 11 19 11–1 years zscore z score age references (a b (b use Ttest T test variables RESULTS men (men 0304 03 04 03–0 55.4% 554 55 0510 05 05–1 57.6% 576 57 6 535 53 53. women 53.5% 63.9% 639 63 9 56.9%, 569 56.9% , 56 56.9%) CONCLUSIONS overweight underweight obesity 3– 51 1 5–1 111 11– 030 0 03– 55.4 051 05– 57.6 63.9 56.9 5– 55. 57. 63. 56.

ABSTRACT BACKGROUND: The effect of weight loss (WL) on histopathological aspects of non-alcoholic fatty liver disease (NAFLD) may provide further insights into the dynamics of hepatic recovery after WL. OBJECTIVE: To analyze the effects of pre-operative WL on insulin resistance- and NAFLD-related histology in individuals undergoing bariatric surgery (BS) with or without pre-operative WL. DESIGN AND SETTING: A matched cross-sectional study was conducted at a public university hospital and a private clinic in Campinas, Brazil. METHODS: An analytical, observational, cross-sectional study was conducted using prospectively collected databases of individuals who underwent BS and liver biopsy at either a public tertiary university hospital (with pre-operative WL) or a private clinic (without pre-operative WL). Random electronic matching by gender, age, and body mass index (BMI) was performed and two paired groups of 24 individuals each were selected. RESULTS: Of the 48 participants, 75% were female. The mean age was 37.4 ± 9.6. The mean BMI was 38.9 ± 2.6 kg/m2. Fibrosis was the most common histopathological abnormality (91.7%). Glucose was significantly lower in the WL group (92 ± 19.1 versus 111.8 ± 35.4 mg/dL; P = 0.02). Significantly lower frequencies of macrovesicular steatosis (58.3% versus 95.8%; P = 0.004), microvesicular steatosis (12.5% versus 87.5%; P < 0.001), and portal inflammation (50% versus 87.5%; P = 0.011) were observed in the WL group. CONCLUSION: Pre-operative WL was significantly associated with lower frequencies of macro- and mi- crovesicular steatosis, portal inflammation, and lower glycemia, indicating an association between the recent trajectory of body weight and histological aspects of NAFLD. BACKGROUND (WL nonalcoholic non alcoholic NAFLD (NAFLD OBJECTIVE preoperative pre operative resistance NAFLDrelated related (BS SETTING crosssectional cross sectional Campinas Brazil METHODS analytical observational . gender (BMI 2 selected RESULTS 4 participants 75 female 374 37 37. 96 9 6 9.6 389 38 38. 26 2. kgm2 kgm kg m2 m kg/m2 91.7%. 917 91.7% 91 7 (91.7%) 92 (9 191 19 1 19. 1118 111 8 111. 354 35 35. mg/dL mgdL mg dL 0.02. 002 0.02 0 02 0.02) 58.3% 583 58 3 (58.3 95.8% 958 95 0.004, 0004 0.004 , 004 0.004) 12.5% 125 12 5 (12.5 87.5% 875 87 0.001, 0001 0.001 001 0.001) 50% 50 (50 0.011 0011 011 CONCLUSION Preoperative Pre macro mi glycemia 9. kg/m 91.7 (91.7% ( 11 00 0.0 58.3 (58. 95.8 000 0.00 12.5 (12. 87.5 (5 0.01 01 91. (91.7 0. 58. (58 95. 12. (12 87. (91. (1 (91

RESUMEN Introducción: El entrenamiento tradicional en hipoxia intermitente mejora el rendimiento deportivo tras cortos periodos de exposición, sin embargo, la exposición aguda a la hipoxia intermitente conduce a una disminución de la intensidad del entrenamiento y de la calidad técnica. La solución para superar estos efectos negativos puede ser realizar los esfuerzos en normoxia y los intervalos entre esfuerzos en hipoxia, manteniendo la calidad del entrenamiento y los beneficios de la hipoxia. Objetivo: Este estudio pretendía evaluar las respuestas fisiológicas agudas a la exposición a la hipoxia durante la recuperación entre esfuerzos de alta intensidad. Materiales y métodos: Estudio aleatorizado, a ciegas y controlado con placebo. Dieciséis hombres realizaron una prueba de ejercicio graduado para determinar su intensidad máxima y dos sesiones de entrenamiento por intervalos de alta intensidad. Los intervalos de entrenamiento podían ser en hipoxia (HRT), FIO2: 0,136 o normoxia (NRT), FIO2: 0,209. Durante el intervalo de dos minutos entre los diez esfuerzos de un minuto, se midieron constantemente la saturación periférica de oxígeno (SpO2), la frecuencia cardiaca (FC), el lactato en sangre ([La]) y la glucemia ([Glu]). Resultados: Hubo diferencias en la FC (TRN = 120 ± 14 lpm; TRH = 129 ± 13 lpm, p < 0,01) y la SpO2 (TRN = 96,9 ± 1,0%; TRH = 86,2 ± 3,5%, p < 0,01). No hubo diferencias en [La] y [Glu] TRN (4,4 ± 1,7 mmol.l-1; 3,9 ± 0,5 mmol.l-1) y TRH (5,2 ± 2,0 mmol.l-1; 4,0 ± 0,8 mmol.l-1, p = 0,17). Conclusión: Se evidenció la posibilidad de incluir hipoxia sólo en los intervalos de recuperación como estímulo adicional al entrenamiento sin disminuir la calidad del mismo. Nivel de Evidencia II; Ensayo Clínico Aleatorizado de Baja Calidad. Introducción embargo técnica Objetivo métodos aleatorizado placebo HRT, HRT , (HRT) FIO2 FIO 0136 0 136 0,13 NRT, NRT (NRT) 0209 209 0,209 minuto SpO2, SpO (SpO2) FC, (FC) ([La] Glu. Glu . ([Glu]) Resultados 12 1 lpm 0,01 001 01 969 96 9 96, 1,0% 10 862 86 2 86, 35 3 5 3,5% 0,01. [La [Glu 4,4 44 4 (4, 17 7 1, mmol.l1 mmoll1 mmoll mmol.l mmol l mmol.l-1 39 3, 05 0, 5,2 52 (5, 20 2, 40 4, 08 8 mmol.l1, 0,17. 017 0,17 0,17) Conclusión mismo II Calidad (HRT 013 0,1 (NRT 020 0,20 (SpO2 (FC ([La ([Glu] 0,0 00 1,0 3,5 (4 l1 mmol.l- 5, (5 02 0,2 (SpO ([Glu (

ABSTRACT Introduction: Traditional intermittent hypoxia training improves sport performance after short periods of exposure, but acute exposure to intermittent hypoxia leads to decreased training intensity and technical quality. The solution to overcome these negative effects may be to perform efforts in normoxia and the intervals between efforts in hypoxia, maintaining the quality of training and the benefits of hypoxia. Objective: This study aimed to evaluate the acute physiological responses to hypoxia exposure during recovery between high intensity efforts. Materials and methods: Randomized, one-blind, placebo-controlled study. Sixteen men performed a graded exercise test to determine their maximal intensity and two sessions of high-intensity interval training. The training intervals could be in hypoxia (HRT), FIO2: 0.136 or normoxia (NRT), FIO2: 0.209. During the two-minute interval between the ten one-minute efforts, peripheral oxygen saturation (SpO2), heart rate (HR), blood lactate ([La]), blood glucose ([Glu]) were constantly measured. Results: There were differences in HR (TRN = 120 ± 14 bpm; TRH = 129 ± 13 bpm, p < 0.01) and SpO2 (TRN = 96.9 ± 1.0%; TRH = 86.2 ± 3.5%, p < 0.01). No differences in [La] and [Glu] TRN (4.4 ± 1.7 mmol.l-1; 3.9 ± 0.5 mmol.l-1) and TRH (5.2 ± 2.0 mmol.l-1; 4.0 ± 0.8 mmol.l-1, p = 0.17). Conclusion: The possibility of including hypoxia only in the recovery intervals as an additional stimulus to the training, without decreasing the quality of the training, was evidenced. Level of Evidence II; Randomized Clinical Trial of Minor Quality. Introduction Objective methods oneblind, oneblind one blind, blind one-blind placebocontrolled placebo controlled highintensity HRT, HRT , (HRT) FIO2 FIO 0136 0 136 0.13 NRT, NRT (NRT) 0209 209 0.209 twominute minute oneminute SpO2, SpO (SpO2) HR, (HR) La, La ([La]) Glu ([Glu] measured Results 12 1 bpm 0.01 001 01 969 96 9 96. 1.0% 10 862 86 2 86. 35 3 5 3.5% 0.01. . [La [Glu 4.4 44 4 (4. 17 7 1. mmol.l1 mmoll1 mmoll mmol.l mmol l mmol.l-1 39 3. 05 0. 5.2 52 (5. 20 2. 40 4. 08 8 mmol.l1, 1, 0.17. 017 0.17 0.17) Conclusion evidenced II Quality (HRT 013 0.1 (NRT 020 0.20 (SpO2 (HR ([La] ([Glu 0.0 00 1.0 3.5 (4 l1 mmol.l- 5. (5 02 0.2 (SpO ([La (

RESUMO Introdução: O treinamento de hipóxia intermitente tradicional melhora o desempenho esportivo após curtos períodos de exposição, porém a exposição aguda à hipóxia intermitente leva à diminuição da intensidade do treinamento e da qualidade técnica. A solução para superar esses efeitos negativos pode ser realizar esforços em normóxia e os intervalos entre os esforços em hipóxia, mantendo a qualidade do treinamento e os benefícios da hipóxia. Objetivo: Este estudo teve como objetivo avaliar as respostas fisiológicas agudas à exposição de hipóxia durante a recuperação entre esforços de alta intensidade. Materiais e métodos: Estudo aleatório e one-blinded, com efeito placebo controlado. Dezesseis homens realizaram um teste de exercício graduado para determinar sua intensidade máxima e duas sessões de treinamento intervalado de alta intensidade. Os intervalos de treinamento podem ser em hipóxia (TRH), FIO2: 0,136 ou normóxia (TRN), FIO2: 0,209. Durante os dois minutos de intervalo entre os dez esforços de um minuto, foram medidos constantemente a saturação periférica de oxigênio (SpO2), frequência cardíaca (FC), lactato sanguíneo ([La]), glicemia ([Glu]). Resultados: Houve diferenças na FC (TRN = 120 ± 14 bpm; TRH = 129 ± 13 bpm, p <0,01) e SpO2 (TRN = 96,9 ± 1,0%; TRH = 86,2 ± 3,5%, p <0,01). Sem diferenças em [La] e [Glu] TRN (4,4 ± 1,7 mmol.l-1; 3,9 ± 0,5 mmol.l-1) e TRH (5,2 ± 2,0 mmol.l-1; 4,0 ± 0,8 mmol.l-1, p = 0,17). Conclusão: Evidenciou-se a possibilidade de incluir a hipóxia apenas nos intervalos de recuperação como um estímulo adicional ao treinamento, sem diminuir a qualidade do treinamento. Nível de Evidência II; Estudo Clínico Randomizado de Menor Qualidade. Introdução técnica Objetivo métodos oneblinded, oneblinded one blinded, blinded one-blinded controlado TRH, , (TRH) FIO2 FIO 0136 0 136 0,13 TRN, (TRN) 0209 209 0,209 minuto SpO2, SpO (SpO2) FC, (FC) La, La ([La]) Glu. Glu . ([Glu]) Resultados 12 1 bpm <0,01 001 01 969 96 9 96, 1,0% 10 862 86 2 86, 35 3 5 3,5% <0,01. [La [Glu 4,4 44 4 (4, 17 7 1, mmol.l1 mmoll1 mmoll mmol.l mmol l mmol.l-1 39 3, 05 0, 5,2 52 (5, 20 2, 40 4, 08 8 mmol.l1, 0,17. 017 0,17 0,17) Conclusão Evidenciouse Evidenciou se II Qualidade (TRH 013 0,1 020 0,20 (SpO2 (FC ([La] ([Glu] <0,0 00 1,0 3,5 (4 l1 mmol.l- 5, (5 02 0,2 (SpO ([La ([Glu <0, ( <0 <

ABSTRACT The use of non-conventional feeds in poultry farming can reduce production costs, mainly because of its low cost, availability and chemical composition. Thus, parboiled whole rice bran (PWRB) appears as a potential use in feeding quails. Two experiments were carried out to evaluate the effects of the inclusion of PWRB in the diet of quails. In each experiment, a total of 288 seven-day-old European quails of both sexes, were distributed in a completely randomized design with six treatments and six replicates of eight quails each. The treatments consisted in the inclusion of PWRB in the proportions of 0; 5; 10; 15; 20 and 25% (first) and 0; 8; 16; 24; 32 and 40% (second). In the first experiment, a linear reduction in feed intake and weight gain was observed with the inclusion of PWRB above 5%, with no significant effect on feed conversion and carcass characteristics. However, there was no loss in the performance and carcass characteristics of quails fed with different levels of PWRB in comparison to the control group. In the second, it was observed that the inclusion of PWRB above 8% promoted a linear reduction in feed intake, weight gain and improvement in feed conversion, with no significant effect on carcass characteristics. However, quails fed 40% PWRB showed reduced intake and weight gain when compared to the control group. The use of PWRB provided an improvement in economic viability. Considering the effect on growth, PWRB can be used in the feeding of meat quails up to 32%. nonconventional non conventional costs cost composition Thus (PWRB experiment 28 sevendayold seven day old sexes 0 5 10 15 2 25 (first 8 16 24 3 40 second. second . (second) 5% However group viability growth 32% 1 4 (second

ABSTRACT This case report presents the details of a 33-year-old female patient who was referred to a specialized retina service because of mild vision loss in her right eye). The patient’s visual acuity was 20/25 in right eye and 20/50 in the left eye (; amblyopic); the spherical equivalent was -12.75 diopters (right eye) and -14.75 diopters (left eye). Multimodal retinal imaging showed peripapillary schisis in both the inner and outer retinal layers, grade II posterior vitreous detachment, and a tessellated fundus. Using Humphrey perimetry and MP-3 microperimetry, the functional evaluation indicated macular sensitivity within normal limits and decreased sensitivity in the peripapillary region, especially in right eye. The pattern-re versal visual evoked potential was measured. The N75 and P100 latency and amplitude in right eye were within normal values for checks of 1º. However, the amplitude was low for checks of 15′. Highly myopic patients who have posterior staphyloma that involves the optic nerve are susceptible to posterior hyaloid traction, and the resulting peripapillary vitreous traction may compromise vision. 33yearold yearold 33 year old . s 2025 20 25 20/2 2050 50 20/5 ( amblyopic amblyopic) 12.75 1275 12 75 -12.7 14.75 1475 14 -14.7 layers detachment fundus MP3 MP 3 MP- microperimetry region patternre pattern re measured N N7 P P10 1º º However 15 15′ 202 2 20/ 205 5 12.7 127 1 7 -12. 14.7 147 -14. P1 12. -12 14. -14 -1 -

RESUMO Este relato de caso apresenta um paciente feminino de 33 anos encaminhado para um serviço especializado de retina devido à leve perda de visão em olho direito. A acuidade visual foi de 20/25 no olho direito e 20/50 no olho esquerdo, o equivalente esférico foi de -12,75 dioptrias e -14,75 dioptrias, respectivamente. Avaliações multimodais revelaram isquese peripapilar nas camadas internas e externas da retina, descolamento vítreo posterior grau II e fundo tesselado. Avaliação funcional com perimetria Humphrey e microperimetria MP-3 revelaram sensibilidade macular normais e diminuição da sensibilidade na região peripapilar, especialmente no olho direito. Potencial visual evocado de padrão reverso apresentou no olho direito latência e amplitude N75 e P100 dentro dos valores normais para verificação de 1º. Entretanto, a amplitude foi baixa para a de 15′. Pacientes alto míopes com esfiloma posterior envolvendo o nervo óptico são suscetíveis à tração da hialoide posterior. Portanto a tração vitreopapilar resultante pode causar comprometimento da visão. 3 2025 20 25 20/2 2050 50 20/5 esquerdo 12,75 1275 12 75 -12,7 14,75 1475 14 -14,7 respectivamente tesselado MP3 MP MP- N N7 P P10 1º º Entretanto 15 15′ 202 2 20/ 205 5 12,7 127 1 7 -12, 14,7 147 -14, P1 12, -12 14, -14 -1 -

Abstract This study aimed to analyze how scientific publications described and interpreted findings about the relationship between the Black population and events linked to COVID-19 in 2020. Narrative review with systematic search, in which a survey was conducted on articles published in 2020 in the Scopus, Medline/PubMed, and Web of Science databases. Initially, 665 articles were found, and after reading and applying the eligible criteria, the final number of 45 articles was reached. Epidemiological, observational studies, secondary data and developed in the United States predominated. Four groupings and respective findings emerged from the synthesis of information extracted: Main events in the Black population - high number of deaths and mortality rate; Direct relationships - poor health, housing, and work conditions; Intermediate relationships - low income and anti-Black prejudice; Comprehensive relationships - structural racism and social determinants of health. The identification of racial health disparities is an important finding about the dynamics of the pandemic among the Black population. However, multicausal explanations were limited. It is necessary to mobilize critical theoretical resources from ethnic and health studies to qualify research in order to support global actions to combat the SARS-CoV-2 epidemic in this group. COVID19 COVID 19 COVID-1 search 202 Scopus MedlinePubMed Medline PubMed Medline/PubMed databases Initially 66 found criteria 4 reached Epidemiological predominated extracted rate housing conditions antiBlack anti prejudice However limited SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- group COVID1 1 COVID- 20 6 SARS-CoV

Resumo Objetiva-se analisar como as publicações científicas descreveram e interpretaram os achados sobre a relação entre a população negra e eventos ligados à COVID-19 em 2020. Revisão narrativa com busca sistemática, na qual realizou-se um levantamento de artigos publicados em 2020 nas bases Scopus, MedLine/PubMed e Web of Science. Inicialmente foram encontrados 665 artigos, após a leitura e aplicação dos critérios elegíveis, chegou-se ao número final de 45 artigos. Predominaram estudos epidemiológicos, observacionais, dados secundários e desenvolvidos nos Estados Unidos. Da síntese das informações extraídas emergiram quatro agrupamentos e respectivos achados: principais eventos na população negra - alto número de óbitos e elevada taxa mortalidade; relações diretas - más condições de saúde, moradia e trabalho; relações intermediárias - baixa renda e preconceito antinegro; relações abrangentes - racismo estrutural e determinantes sociais da saúde. A identificação das disparidades raciais em saúde é uma importante constatação sobre a dinâmica da pandemia entre a população negra, porém as explicações multicausais mostraram-se limitadas. É necessário mobilizar recursos teóricos críticos dos estudos de raça e saúde para qualificar pesquisas, visando oferecer suporte em ações globais no enfrentamento da epidemia por SARS-COV2 neste grupo. Objetivase Objetiva se COVID19 COVID 19 COVID-1 sistemática realizouse realizou 202 Scopus MedLinePubMed MedLine PubMed Science 66 elegíveis chegouse chegou 4 epidemiológicos observacionais Unidos mortalidade trabalho antinegro mostraramse mostraram limitadas pesquisas SARSCOV2 SARSCOV SARS COV2 COV SARS-COV grupo COVID1 1 COVID- 20 6 2

ABSTRACT BACKGROUND: The concept introduced by protocols of enhanced recovery after surgery modifies perioperative traditional care in digestive surgery. The integration of these modern recommendations components during the perioperative period is of great importance to ensure fewer postoperative complications, reduced length of hospital stay, and decreased surgical costs. AIMS: To emphasize the most important points of a multimodal perioperative care protocol. METHODS: Careful analysis of each recommendation of both ERAS and ACERTO protocols, justifying their inclusion in the multimodal care recommended for digestive surgery patients. RESULTS: Enhanced recovery programs (ERPs) such as ERAS and ACERTO protocols are a cornerstone in modern perioperative care. Nutritional therapy is fundamental in digestive surgery, and thus, both preoperative and postoperative nutrition care are key to ensuring fewer postoperative complications and reducing the length of hospital stay. The concept of prehabilitation is another key element in ERPs. The handling of crystalloid fluids in a perfect balance is vital. Fluid overload can delay the recovery of patients and increase postoperative complications. Abbreviation of preoperative fasting for two hours before anesthesia is now accepted by various guidelines of both surgical and anesthesiology societies. Combined with early postoperative refeeding, these prescriptions are not only safe but can also enhance the recovery of patients undergoing digestive procedures. CONCLUSIONS: This position paper from the Brazilian College of Digestive Surgery strongly emphasizes that the implementation of ERPs in digestive surgery represents a paradigm shift in perioperative care, transcending traditional practices and embracing an intelligent approach to patient well-being. BACKGROUND stay costs AIMS protocol METHODS RESULTS (ERPs thus vital societies refeeding procedures CONCLUSIONS wellbeing. wellbeing well being. being well-being

RESUMO RACIONAL: O conceito introduzido pelos protocolos de recuperação após a cirurgia modifica os cuidados perioperatórios tradicionais em cirurgia digestiva. A integração desses componentes modernos de recomendações, durante o período perioperatório, é de grande importância para garantir menos complicações pós-operatórias, redução do tempo de internação hospitalar e diminuição dos custos cirúrgicos. OBJETIVOS: Enfatizar os pontos mais importantes de um protocolo multimodal de cuidados perioperatórios. MÉTODOS: Análise criteriosa de cada recomendação dos protocolos ERAS e ACERTO, justificando sua inclusão no atendimento multimodal recomendado para pacientes de cirurgia digestiva. RESULTADOS: Os programas de recuperação avançada (PRAs), tais como os protocolos ERAS e ACERTO, são a base dos cuidados perioperatórios modernos. A terapia nutricional é de grande importância na cirurgia digestiva e, portanto, tanto os cuidados nutricionais pré-operatórios, quanto pós-operatórios são fundamentais para garantir menos complicações pós-operatórias e reduzir o tempo de internação hospitalar. O conceito de pré-habilitação é outro elemento-chave nos PRAs. O manuseio de fluidos cristalóides em perfeito equilíbrio é vital. A sobrecarga de fluidos pode atrasar a recuperação dos pacientes e aumentar as complicações pós-operatórias. A abreviação do jejum pré-operatório para duas horas antes da anestesia é agora aceita por diversas diretrizes das sociedades cirúrgicas e de anestesiologia. Combinadas com a realimentação pós-operatória precoce, essas prescrições não são apenas seguras, mas também podem melhorar a recuperação de pacientes submetidos a procedimentos digestivos. CONCLUSÕES: Este posicionamento do Colégio Brasileiro de Cirurgia Digestiva enfatiza fortemente que a implementação de PRAs em cirurgia digestive, representa uma mudança de paradigma no cuidado perioperatório, transcendendo as práticas tradicionais e adotando uma abordagem inteligente para o bem-estar do paciente. RACIONAL recomendações perioperatório pósoperatórias, pósoperatórias pós operatórias, operatórias cirúrgicos OBJETIVOS MÉTODOS ACERTO RESULTADOS PRAs, , (PRAs) portanto préoperatórios, préoperatórios pré operatórios, operatórios pré-operatórios pósoperatórios préhabilitação habilitação elementochave elemento chave vital pósoperatórias. operatórias. préoperatório operatório anestesiologia pósoperatória operatória precoce seguras digestivos CONCLUSÕES digestive bemestar bem estar paciente (PRAs