Pesquisa | SciELO

Resumo Fundamento: A Cardiomiopatia Chagásica Crônica (CCC) é causada por um processo inflamatório induzido pelo Trypanosoma cruzi, que leva à miocardite com fibrose reativa e reparativa. A CCC progride com alterações de perfusão miocárdica e eventos histopatológicos que afetam a Aptidão Cardiorrespiratória (ACR). Objetivos: Avaliamos os efeitos do Treinamento Físico Aeróbico (TFA) na perfusão miocárdica e nos comprometimentos morfológicos e funcionais relacionados à inflamação e fibrose em hamsters sírios com CCC. Como objetivo secundário, analisamos as áreas de secção transversa do músculo esquelético. Métodos: Hamsters com CCC e seus respectivos controles foram divididos em quatro grupos: CCC sedentário, CCC-TFA, controle sedentário e controle TFA. Sete meses após a infecção, os animais foram submetidos à ecocardiografia, à cintilografia de perfusão miocárdica e ao teste de esforço cardiopulmonar. TFA de intensidade moderada foi realizado durante cinquenta minutos, cinco vezes por semana, por oito semanas. Posteriormente, os animais foram reavaliados. A análise histopatológica foi realizada após os procedimentos acima mencionados. O nível de significância foi estabelecido em 5% em todas as análises (p<0,05). Resultados: Animais com CCC sedentários apresentaram piores Defeitos de Perfusão Miocárdica (DPM) ao longo do tempo, Fração de Ejeção do Ventrículo Esquerdo (FEVE) reduzida, e apresentaram mais inflamação e fibrose quando comparados aos demais grupos (análise ANOVA mista). Por outro lado, o TFA foi capaz de mitigar a progressão do DPM, atenuar a inflamação e a fibrose e melhorar a eficiência da ACR em animais CCC-TFA. Conclusão: Nosso estudo demonstrou que o TFA melhorou a disfunção cardíaca, DPM e reduziu a inflamação e a fibrose em modelos de hamster com CCC. Além disso, os animais CCC-SED apresentaram atrofia do músculo esquelético, enquanto os animais CCC-TFA apresentaram a AST do músculo esquelético preservada. Compreender os efeitos da TFA nas dimensões fisiopatológicas da CCC é crucial para futuras pesquisas e intervenções terapêuticas. Fundamento (CCC cruzi reparativa ACR. . (ACR) Objetivos (TFA secundário Métodos CCCTFA, CCCTFA TFA, infecção ecocardiografia cardiopulmonar minutos semana semanas Posteriormente reavaliados mencionados 5 p<0,05. p005 p p<0,05 0 05 (p<0,05) Resultados (DPM tempo FEVE (FEVE reduzida mista. mista mista) lado CCCTFA. Conclusão cardíaca disso CCCSED SED preservada terapêuticas (ACR p00 p<0,0 (p<0,05 p0 p<0, (p<0,0 p<0 (p<0, p< (p<0 (p< (p

Abstract Background: Chronic Chagas cardiomyopathy (CCC) is caused by an inflammatory process induced by Trypanosoma cruzi, which leads to myocarditis with reactive and reparative fibrosis. CCC progresses with myocardial perfusion abnormalities and histopathological events that affect cardiorespiratory fitness (CRF). Objectives: We evaluated the effects of aerobic physical training (APT) on myocardial perfusion and on morphological and functional impairments related with inflammation and fibrosis in Syrian hamsters with CCC. As a secondary objective, we analyzed the cross-sectional areas of the skeletal muscle. Methods: Hamsters with CCC and their respective controls were divided into four groups: CCC sedentary, CCC-APT, sedentary control and APT control. Seven months after infection, the animals underwent echocardiography, myocardial perfusion scintigraphy and cardiopulmonary exercise testing. Moderate-intensity APT was performed for fifty minutes, five times a week, for eight weeks. Subsequently, the animals were reassessed. Histopathological analysis was conducted after the above-mentioned procedures. The level of significance was set at 5% in all analyses (p<0.05). Results: CCC sedentary animals presented worse myocardial perfusion defects (MPD) over time, reduced left ventricle ejection fraction (LVEF) and showed more inflammation and fibrosis when compared to other groups (mixed ANOVA analysis). Conversely, APT was able to mitigate the progression of MPD, ameliorate inflammation and fibrosis and improve CRF efficiency in CCC-APT animals. Conclusions: Our study demonstrated that APT ameliorated cardiac dysfunction, MPD, and reduced inflammation and fibrosis in CCC hamster models. Additionally, CCC-SED animals presented skeletal muscle atrophy while CCC-APT animals showed preserved skeletal muscle CSA. Understanding APT's effects on CCC's pathophysiological dimensions is crucial for future research and therapeutic interventions. Background (CCC cruzi CRF. . (CRF) Objectives (APT objective crosssectional cross sectional Methods CCCAPT, CCCAPT APT, infection echocardiography testing Moderateintensity Moderate intensity minutes week weeks Subsequently reassessed abovementioned above mentioned procedures 5 p<0.05. p005 p p<0.05 0 05 (p<0.05) Results MPD (MPD time LVEF (LVEF mixed analysis. analysis) Conversely Conclusions dysfunction models Additionally CCCSED SED CSA APTs s CCCs interventions (CRF p00 p<0.0 (p<0.05 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

https://doi.org/10.36660/abc.20230707

PHYSIOLOGICAL QUALITY OF PROCESSED, REPROCESSED, AND STORED SORGHUM SEEDS: IMPACT OF A DENSIMETRIC TABLE PROCESSED REPROCESSED SEEDS
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Cabral, Erica de F.

; Resende, Osvaldo

; Oliveira, Daniel E. C. de

; Costa, Lílian M.

; Santos, Jonathas L. R. dos

Engenharia Agrícola

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2023, Volume 43 Nº 2 elocation e20220138

Resumo: En | Texto: En | PDF: En

ABSTRACT Sorghum ( Sorghum bicolor L. Moench) is a crop of paramount importance for Brazil, used in human and animal food. Considering the reduced number of studies on the influence of using a densimetric table in seed processing and its respective reprocessing to the equipment, this study aimed to evaluate the physiological quality of processed sorghum seeds reprocessed in a densimetric table and stored for three months. The treatments consisted of four collection points in the terminal part of the densimetric table, representing the processing material: upper part (P1), upper middle part (P2), middle part (P3), and lower part (D). Subsequently, the samples that were reprocessed in the table came from P3 and were divided into the upper part, which was followed to bagging (P3R1), and the lower part (P3R2), which followed for disposal, totaling six treatments. Storage was performed in a refrigerated environment, using a completely randomized design, with the means being compared by Tukey’s test at 5%. We concluded that the reprocessing of sorghum seeds in the densimetric table can improve the physical quality of a lot due to its standardization at the end of the stages, contributing to the improvement of the physiological quality and use of the material that would be discarded. The equipment performance allows the removal of seed fractions with lower apparent specific mass and promotes positive stratifications in the physiological quality of sorghum seed lots. L Moench Brazil food months P1, P1 P , (P1) P2, P2 (P2) P3, (P3) D. D . (D) Subsequently P3R1, P3R1 PR R (P3R1) P3R2, P3R2 (P3R2) disposal environment design Tukeys Tukey s 5 5% stages discarded lots (P1 (P2 (P3 (D P3R (P3R1 (P3R2 (P (P3R

https://doi.org/10.1590/1809-4430-eng.agric.v43n2e20220138/2023

Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1,4-Naphthoquinone Sulfonamide and Sulfonate Ester Derivatives
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Pacheco, Paulo A. F.

; Gonzaga, Daniel T.

; Cirne-Santos, Cláudio C.

; Barros, Caroline S.

; Gomes, Max W. L.

; Gomes, Rafaela S. P.

; Gonçalves, Mariana C.

; Ferreira, Vitor F.

; Rabelo, Vitor W.

; Abreu, Paula A.

; Faria, Robson X.

; Resende, Gabriel O. de

; Rocha, David R. da

; Paixão, Izabel C. N. P.

; Silva, Fernando C. da

Journal of the Brazilian Chemical Society

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Jun 2022, Volume 33 Nº 6 Páginas 556 - 569

Resumo: En | Texto: En | PDF: En

Chikungunya virus (CHIKV) is a re-emerging disease caused by an alphavirus of the Togaviridae family. Since its first description in 1952, the disease has spread worldwide, affecting populations in both tropical and temperate countries. To date, there is no licensed vaccine or specific pharmacological treatment. Therefore, there is an increasing urgency in developing new antiviral drugs capable of specifically inhibiting viral replication. In the present work, we report the synthesis and antiviral activity evaluation of nineteen naphthoquinone derivatives, containing a sulfonamide or sulfonate group. Cell viability assays indicated a low toxic potential for all tested compounds and inhibitory assays against CHIKV identified five compounds with potent activity. The compounds were also evaluated for their virucidal potential, and the results demonstrated that compound 11a exhibited a virucidal effect higher than 70% in the treatment with 20 µM. Furthermore, in silico studies were performed to predict the antiviral drug targets.

https://doi.org/10.21577/0103-5053.20220010

Geographical distribution and resistance level to chlorimuron of Amaranthus spp. populations in the main soybeans producing regions of Brazil
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Netto, Acácio Gonçalves

; Resende, Laís S.

; Malardo, Marcelo R.

; Presoto, Jéssica C.

; Andrade, Jeisiane de F.

; Nicolai, Marcelo

; Ovejero, Ramiro F. L.

; Carvalho, Saul J. P. de

Advances in Weed Science

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2022, Volume 40 Nº spe2 elocation e020220063

Resumo: En | Texto: En | PDF: En

Abstract Background Species of Amaranthus genus are common in agricultural areas of Brazil. Such weeds are problematic, and they bring complexity to the management mainly due to herbicide resistance. Thus, the monitoring and mapping of chlorimuron-resistant Amaranthus spp. is necessary to detect resistance in different locations of Brazil. Objective Elaborate discriminating dose of distinction between Amaranthus spp. populations that are susceptible and resistant to chlorimuron and monitor the resistance dispersal throughout five crops. Methods 33 pigweed populations from the main grain producing properties in Brazil by means of dose-response curves were evaluated. For the D dose, chlorimuron dose of 20 g ha-1 ai was considered. Once the discriminating dose was identified, a monitoring screening of the dispersal of resistance of Amaranthus spp. to chlorimuron was conducted with 226 samples between the 2016 and 2020 crops. Results The discriminating dose (“base line”) considered ideal to control susceptible plants was 20 g ha-1 of chlorimuron. Among 226 pigweed samples evaluated in the five years of monitoring, 74% of populations were considered susceptible (S), while those classified as resistant (R) and segregating (r) did not exceed 26.0%. Conclusions By comparing susceptible biotypes of Amaranthus spp. with international scientific literature standards and leaflet averages, it could be safely concluded that the discriminating dose of chlorimuron is 20 g ha-1. Resistance of Amaranthus spp. to chlorimuron in Brazil is present in the main soybean producing regions evaluated, with a frequency of 26% of the total samples evaluated.

https://doi.org/10.51694/advweedsci/2022;40:amaranthus010

Phytosociology of weeds on Cerrado Mineiro coffee growing farms
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Rodrigues, Rafael J. A.

; Carvalho, Gladyston R.

; Gonçalves, Adenilson H.

; Carvalho, João Paulo F.

; Alcântara, Elifas N. de

; Resende, Laís S.

Advances in Weed Science

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2022, Volume 40 elocation e020220029

Resumo: En | Texto: En | PDF: En

Abstract Background Phytosociological surveys of weeds in agricultural regions, such as the coffee growing Cerrado Mineiro Denomination, are essential for understanding the predominant species in a cultivation area. Objective This study aimed to determine the predominant weed species in coffee crops in Cerrado Mineiro through phytosociological surveys during two periods of the year. Methods 26 coffee farms in 12 municipalities within the Cerrado Mineiro Denomination of Origin of were visited. The inventory square method was used for the phytosociological surveys. In each area, 40 m2 was evaluated and divided into two study periods (summer and winter). Calculations of the variables were performed using the following data: frequency, density, abundance, importance value index, similarity coefficient, rarefaction curve, Shannon index, and hierarchical grouping analysis using Jaccard’s similarity. Results In the summer (rainy period), 54 species from 16 families were found, with Poaceae, Asteraceae, and Amaranthaceae predominating. In winter (dry season), 56 species from 16 families were found, predominantly Asteraceae, Poaceae, and Brassicaceae. There was a predominance of 17 and 16 species, with similarity levels (Jaccard) of 45.58% and 40.78% for summer and winter, respectively. Conclusions The weed community in the Cerrado Mineiro coffee plantation is dominated by two main families, Poacaeae and Asteraceae, with Eleusine indica (summer) and Conyza spp. (winter) being the species with the highest importance values.

https://doi.org/10.51694/advweedsci/2022;40:00013

Adsorption isotherms and thermodynamic properties of Carthamus tinctorius L. seeds
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Bessa, Jaqueline F. V.

; Resende, Osvaldo

; Oliveira, Daniel E. C. de

; Lima, Rayr R. de

; Quequeto, Wellytton D.

; Siqueira, Valdiney C.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Ago 2021, Volume 25 Nº 10 Páginas 696 - 702

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O cártamo é uma cultura de elevado valor econômico que possui alto teor de óleo nos grãos e grande versatilidade industrial com vários benefícios à saúde humana. Assim, como outras culturas agrícolas é comum o armazenamento do cártamo para disponibilização em diferentes épocas do ano, e devido suas características higroscópicas tornam-se relevantes estudos que avaliem o efeito da temperatura e da umidade relativa do ar no teor de água. Deste modo, objetivou-se neste estudo determinar as isotermas de adsorção de água das sementes de cártamo e analisar as propriedades termodinâmicas. Os teores de água de 6,5; 6,9; 7,3; 7,7; 8,3 e 9,1% (base seca) foram obtidos por adsorção em condições controladas de temperatura (30 °C) e umidade relativa do ar (90%). As isotermas de adsorção foram obtidas pelo método estático indireto em diferentes temperaturas (10, 20, 30 e 40 °C). Com o aumento da temperatura, para um mesmo teor de água, tem-se elevação da atividade de água e, para uma atividade de água constante, os valores do teor de água de equilíbrio diminuíram com o aumento da temperatura. O modelo de Chung-Pfost apresentou o melhor ajuste para descrever o fenômeno de higroscopicidade das sementes de cártamo. As propriedades termodinâmicas foram influenciadas pelo teor de água das sementes, reduzindo a energia necessária para a absorção de água no produto com o aumento da adsorção, sendo a teoria da compensação entalpia-entropia controlada pela entalpia.

ABSTRACT Safflower is a crop of high economic value with high oil concentration in its seeds and great industrial versatility, besides various benefits to human health. As with other agricultural crops, it is common to store safflower to make it available in different periods of the year and, due to its hygroscopic characteristics, studies evaluating the effect of temperature and air relative humidity on its moisture content become relevant. Thus, the objective of the present study was to determine the water adsorption isotherms of safflower seeds and analyze their thermodynamic properties. Moisture contents of 6.5, 6.9, 7.3, 7.7, 8.3 and 9.1% (dry basis) were obtained by adsorption under controlled conditions of temperature (30 °C) and relative air humidity (90%). The adsorption isotherms were obtained by the indirect static method at different temperatures (10, 20, 30 and 40 °C). As temperature increased, for the same moisture content, there was an increase in water activity and, for constant water activity, the values of equilibrium moisture content decreased with increasing temperature. Chung-Pfost model showed the best fit to describe the phenomenon of hygroscopicity of safflower seeds. The thermodynamic properties were influenced by the moisture content of the seeds, reducing the energy necessary for water absorption in the product with the increase in adsorption, and the enthalpy-entropy theory was controlled by enthalpy.

https://doi.org/10.1590/1807-1929/agriambi.v25n10p696-702 2 downloads

Crystal Structure and 1H NMR Experimental and Theoretical Study of Conformers of 5-Methyl-1-(4’-methylphenylsulfonylamino)-1H-[1,2,3]-triazole-4-carboxylic Acid Ethyl Ester and 5-Methyl-1-(phenylsulfonylamino)-1H-[1,2,3]-triazole-4-carboxylic Acid Ethyl Ester
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Freitas, Maria C. R.

; Campos, Vinicius R.

; Resende, Jackson A. L. C.

; Silva, Marcos M. P. da

; Ferreira, Vitor F.

; Cunha, Anna Claudia

; Carneiro, José W. M.

; Lage, Mateus R.

; Souza, Leonardo A. de

; Silva, Haroldo C.

; Almeida, Wagner B. de

Journal of the Brazilian Chemical Society

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Mai 2020, Volume 31 Nº 5 Páginas 867 - 885

Resumo: En | Texto: En | PDF: En

We reported experimental and theoretical investigation of conformers of 1,2,3-triazole derivatives, substances of exclusively synthetic origin, subject of extensive studies, because of several biological properties, such as antiviral, antimicrobial and antileishmaniasis. We reported molecular/supramolecular X-ray structures of antiophidian compounds I and II. For I and II there are two crystallographic different molecules in the unit cell (A and B). To explore the causes of the similarities in the compound’s crystal structures, intermolecular interactions were explored using the Hirshfeld surface as the fingerprint plots. In addition, density functional theory (DFT) calculations were carried out at the ωB97x-D/6-31G(d,p)-PCM-CHCl3 level aiming to contribute to the interpretation of the experimental data and complement the experimental findings. Two structures named 2A and 5B were found in good agreement with the respective X-ray solid state ones (A and B). Theoretical 1H nuclear magnetic resonance (NMR) spectra calculated for 5B rotated structure (torsion angles deviation around 40° to 90°) was in fine agreement with experimental results (in CDCl3) indicating that the solution molecular structure is considerably different from optimized equilibrium geometries and solid-state structure. Therefore, care is needed when using X-ray structures or DFT geometries to model interaction of drugs with biological targets since significant conformational changes may take place in solution.

https://doi.org/10.21577/0103-5053.20190249 267 downloads

Diversidade de presas e predadores (Insecta) em mesohabitats de córregos de Cerrado
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Giehl, Nubia F. S.

; Resende, Bethânia O.

; Roges, Paulo F. S. S.

; Dias-Silva, Karina

; Nogueira, Denis S.

; Cabette, Helena S. R.

Iheringia. Série Zoologia

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2018, Volume 108 elocation e2018042

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Córregos tropicais apresentam alta variedade de hábitats e gradientes ambientais, que refletem na maior riqueza de insetos aquáticos. Dessa forma, avaliamos se a diversidade de insetos aquáticos das categorias presa e predador é influenciada pelo tipo de substratos ou por porções longitudinais em córregos de Cerrado. Nossa hipótese é que a diversidade de presa e predador será determinada pelo tipo de substrato, partindo do pressuposto de que o substrato serve como fonte para forrageamento e/ou refúgio. Ademais, o substrato folhiço apresentará maior abundância e riqueza devido à disponibilidade de abrigo e alimento provida por esse tipo de substrato. Haverá diferença na composição de presa e predador entre substratos, pois algumas espécies apresentam associações com o tipo de substrato. As porções do córrego não exercerão efeito sobre a diversidade de presa e predador, uma vez que, em córregos de até terceira ordem não apresenta mudanças consideráveis nas características físicas. O estudo foi realizado nas porções nascente (1ª ordem), intermediário (2ª) e foz (3ª), em dois córregos, nos períodos seco e chuvoso. Foram coletadas cinco subamostras de areia, cascalho, rochas ou matacões, folhiço de remanso, de corredeira e raízes (substrato). O substrato influenciou todas as variáveis respostas de presa e predador (abundância, riqueza e composição), porém, o ambiente (porções longitudinais) não influenciou a abundância e composição de predador. A influência de substratos para a diversidade de presas e predadores evidencia a importância da vegetação ripária como fonte de material alóctone em córregos de cabeceira.

ABSTRACT Tropical streams feature high variety of habitats and environmental gradients, which reflect on the greater richness of aquatic insects. In this way, we evaluate if the diversity of aquatic insects of prey and predator categories is influenced by the type of substrates or by longitudinal portions in Cerrado streams. Our hypothesis is that prey and predator diversity will be determined by the type of substrate, assuming that the substrate serves as a source for foraging and / or refuge. In addition, the folhiço substrate will present greater abundance and richness due to the availability of shelter and food provided by this type of substrate. There will be differences in prey and predator composition among substrates, since some species have associations with the substrate type. The portions of the stream will have no effect on the diversity of prey and predator, since in streams of up to third order does not present considerable changes in physical characteristics. The study was carried out in nascent (1st order), intermediate (2nd) and estuary (3rd), in two streams, during dry and rainy periods. Five subsamples of sand, gravel, rocks or boulders were collected, backwaters, rapids and roots (substrate). The substrate influenced all prey and predator responses (abundance, richness and composition), but the environment (longitudinal portions) did not influence the abundance and predator composition. The influence of substrates on the diversity of prey and predators evidences the importance of riparian vegetation as a source of allochthonous material in bedside streams.

https://doi.org/10.1590/1678-4766e2018042 1353 downloads

Rare Earth-Indomethacinate Complexes with Heterocyclic Ligands: Synthesis and Photoluminescence Properties
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Resende Filho, João Batista M.

; Santos, Paulo R.

; Vale, Juliana A.

; Faustino, Wagner M.

; Farias, Danyelle S.

; Brito, Hermi F.

; Felinto, Maria C. F. C.

; Teotonio, Ercules E. S.

Journal of the Brazilian Chemical Society

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Dez 2017, Volume 28 Nº 12 Páginas 2281 - 2290

Resumo: En | Texto: En | PDF: En

In this work, synthesis, characterization and photophysical properties of trivalent rare earth complexes with a nonsteroidal anti-inflammatory drug [the indomethacinate (indo), presenting formulas RE(indo)3(H2O)x (x = 3, for Eu3+ and Gd+3, and x = 4 for Tb+3), RE(indo)3(bipy) and RE(indo)3(phen) (bipy: 2,2'-bipyridine, and phen: 1,10-phenanthroline)] were investigated. Based on photoluminescent results, the intramolecular energy transfer process from T1 triplet states of indo, phen and bipy ligands to the 5D0 emitting level of the Eu3+ ion in the coordination compounds is discussed. Accordingly, it is proposed two possible intramolecular energy transfer mechanisms between indomethacinate ligand and rare earth ions, which involve the participation of excited electronic states of the heterocyclic ligands as intermediate ones.

https://doi.org/10.21577/0103-5053.20170079 671 downloads

10.

Synthesis of New Xanthenes Based on Lawsone and Coumarin via a Tandem Three-Component Reaction
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Cardoso, Mariana F. C.

; Forezi, Luana S. M.

; Cavalcante, Victor G. S.

; Juliani, Cecília S. R.

; Resende, Jackson Antônio L. C.

; Rocha, David R. da

; Silva, Fernando C. da

; Ferreira, Vitor F.

Journal of the Brazilian Chemical Society

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Out 2017, Volume 28 Nº 10 Páginas 1926 - 1936

Resumo: En | Texto: En | PDF: En

The synthesis of several new xanthenes based on the 1,3-dicarbonyl scaffolds lawsone and coumarin was developed using tandem three-component reactions involving the reagents ortho-hydroxybenzaldehyde, as bifunctional reagent, and an appropriate thiol. These reactions generated two series of para- and ortho-naphthoxanthenes that are structurally related to α- and β-pyranaphthoquinones and one series of coumarin-xanthene derivatives.

https://doi.org/10.21577/0103-5053.20170032 913 downloads

11.

Brazilian consensus on Duchenne muscular dystrophy. Part 1: diagnosis, steroid therapy and perspectives
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Araujo, Alexandra P. Q. C.

; Carvalho, Alzira A. S. de

; Cavalcanti, Eduardo B. U.

; Saute, Jonas Alex M.

; Carvalho, Elmano

; França Junior, Marcondes C.

; Martinez, Alberto R. M.

; Navarro, Monica de M. M.

; Nucci, Anamarli

; Resende, Maria Bernadete D. de

; Gonçalves, Marcus Vinicius M.

; Gurgel-Giannetti, Juliana

; Scola, Rosana H.

; Sobreira, Cláudia F. da R.

; Reed, Umbertina C.

; Zanoteli, Edmar

Arquivos de Neuro-Psiquiatria

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Ago 2017, Volume 75 Nº 8 Páginas 104 - 113

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Avanços na compreensão e no manejo da distrofia muscular de Duchenne (DMD) ocorreram desde a publicação de diretrizes internacionais em 2010. Nosso objetivo foi elaborar um consenso nacional baseado em evidências de cuidado multidisciplinar dos pacientes com DMD no Brasil. Utilizamos a técnica de Delphi combinada com revisão sistemática da literatura de 2010 a 2016 classificando níveis de evidência e graus de recomendação. Nossas recomendações foram divididas em duas partes. Apresentamos aqui a parte 1, descrevendo a metodologia utilizada e conceitos gerais da doença, e fornecemos recomendações sobre diagnóstico, tratamento com corticosteroides e novas perspectivas de tratamentos medicamentosos. As principais recomendações: 1) testes genéticos deveriam ser a primeira linha para confirmação de casos suspeitos; 2) pacientes com diagnóstico de DMD devem receber corticosteroides; 3) por enquanto, a falta de publicações de resultados dos ensaios clínicos de fase 3, dificulta recomendações de uso medicamentos que “saltam exons” ou “passam” por código de parada prematura.

ABSTRACT Significant advances in the understanding and management of Duchenne muscular dystrophy (DMD) took place since international guidelines were published in 2010. Our objective was to provide an evidence-based national consensus statement for multidisciplinary care of DMD in Brazil. A combination of the Delphi technique with a systematic review of studies from 2010 to 2016 was employed to classify evidence levels and grade of recommendations. Our recommendations were divided in two parts. We present Part 1 here, where we describe the guideline methodology and overall disease concepts, and also provide recommendations on diagnosis, steroid therapy and new drug treatment perspectives for DMD. The main recommendations: 1) genetic testing in diagnostic suspicious cases should be the first line for diagnostic confirmation; 2) patients diagnosed with DMD should have steroids prescribed; 3) lack of published results for phase 3 clinical trials hinders, for now, the recommendation to use exon skipping or read-through agents.

https://doi.org/10.1590/0004-282x20170112 10268 downloads

12.

Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil
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Matos, Diana M.

; Ramalho, Roberto J. R.

; Carvalho, Bruno M.

; Almeida, Maria Augusta C. T.

; Passos, Luciana F. D.

; Vasconcelos, Talmay T. S.

; Melo, Enaldo V.

; Oliveira, Carla R. P.

; Santos, Elenilde G.

; Resende, Karla F.

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

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Out 2016, Volume 60 Nº 5 Páginas 450 - 456

Resumo: En | Texto: En | PDF: En

ABSTRACT Objectives To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. Subjects and methods Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the confirmatory serum TSH values, the children were diagnosed with initial congenital hypothyroidism (CH) or suspect CH. From the evolution, they were classified as permanent CH, hyperthyrotropinemia, or transient TSH elevation. The mean incidence of each final condition was calculated for the total period of time. Results The initial diagnosis included 37 CH (18.1%) and 167 suspect CH (81.9%) cases. The final diagnosis included 46 cases of permanent CH (22.5%), 56 of hyperthyrotropinemia (27.5%), and 102 of transient TSH elevation (50.0%). Out of the 37 cases of initial CH, 23 (62.2%) had permanent CH, nine (24.3%) had hyperthyrotropinemia, and five (13.5%) had transient TSH elevation. Out of the 167 suspect CH cases, 23 (13.8%) had permanent CH, 47 (28.1%) had hyperthyrotropinemia and 97 (58.1%) had transient TSH elevation. The mean incidence after the follow up was 1:4,166 for permanent CH, 1:3,448 for hyperthyrotropinemia, and 1:1,887 for transient TSH elevation. Eighty-six percent of the children with an initial diagnosis of CH and 41.9% with suspect CH had a permanent condition (CH or hyperthyrotropinemia). Conclusions The follow-up of children with an initial diagnosis of CH or suspect CH is necessary to determine whether the disorder is permanent because predicting the evolution of the condition is difficult.

https://doi.org/10.1590/2359-3997000000189 1374 downloads

13.

Angiosarcoma of small intestine: case report and literature review
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Lopes, Roberto Heleno

; Resende, Frederico Augustus M.

; Fraga, João Baptista P.

; Oliveira, Alexandre F.

; Pereira, Matheus S. V.

; Maciel, Bruno A. R.

; Lamim, Raul Fernando B.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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Out 2016, Volume 52 Nº 5 Páginas 345 - 348

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Angiossarcomas são patologias raras, e o aparecimento deles no intestino delgado é extremamente incomum. Relato de caso: Paciente do sexo feminino apresentando vômitos, cólica, distensão abdominal e irritação peritoneal. Foram realizadas laparotomia exploratória e enterectomia, evidenciando-se neoplasia vascular ao anatomopatológico e marcadores CD31, p53 e antígeno de proliferação celular Ki-67 à imuno-histoquímica. A paciente evoluiu com sarcomatose difusa e faleceu dois meses após o início dos sintomas. Conclusão: Demonstra-se a dificuldade em diagnosticar precocemente essa patologia devido à sua clínica inespecífica. A agressividade da doença, seus fatores predisponentes indeterminados e a controvérsia referente ao tratamento adequado suscitam seu péssimo prognóstico.

ABSTRACT Introduction: Angiosarcomas are rare pathologies, and their appearance in the small intestine is extremely unusual. Case report: Female patient presenting vomiting, colic, abdominal distension and peritoneal irritation. An exploratory laparotomy and an enterectomy were performed. Histopathology revealed vascular neoplasm; immunohistochemistry, markers CD31, p53 and cell proliferation antigen Ki-67. The patient developed diffuse sarcomatosis and died two months after the onset of symptoms. Conclusion: This case demonstrates the difficulty in early diagnosing this pathology, due to its nonspecific clinical presentation. The disease aggressiveness, its unestablished predisposing factors and the controversy around the adequate treatment engender the poor prognosis.

https://doi.org/10.5935/1676-2444.20160054 1006 downloads

14.

Qualidade de vida nas espondiloartrites: análise de uma grande coorte brasileira
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Ribeiro, Sandra L.E.

; Albuquerque, Elisa N.

; Bortoluzzo, Adriana B.

; Gonçalves, Célio R.

; Silva, José Antonio Braga da

; Ximenes, Antonio Carlos

; Bértolo, Manoel B.

; Keiserman, Mauro

; Menin, Rita

; Skare, Thelma L.

; Carneiro, Sueli

; Azevedo, Valderílio F.

; Vieira, Walber P.

; Bianchi, Washington A.

; Bonfiglioli, Rubens

; Campanholo, Cristiano

; Carvalho, Hellen M.S.

; Costa, Izaias P.

; Duarte, Angela L.B. Pinto

; Kohem, Charles L.

; Leite, Nocy H.

; Lima, Sonia A.L.

; Meirelles, Eduardo S.

; Pereira, Ivânio A.

; Pinheiro, Marcelo M.

; Polito, Elizandra

; Resende, Gustavo G.

; Rocha, Francisco Airton C.

; Santiago, Mittermayer B.

; Sauma, Maria de Fátima L.C.

; Valim, Valéria

; Sampaio-Barros, Percival D.

Revista Brasileira de Reumatologia

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Fev 2016, Volume 56 Nº 1 Páginas 22 - 27

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Analisar as variáveis demográficas e clínicas associadas à diminuição da qualidade de vida em uma grande coorte brasileira de pacientes com espondiloartrite (EpA). Métodos: Foi aplicado um protocolo de pesquisa único a 1.465 pacientes brasileiros classificados como tendo EpA de acordo com os critérios do European Spondyloarthropaties Study Group (ESSG), atendidos em 29 centros de referência em reumatologia do Brasil. Foram registradas as variáveis clínicas e demográficas. A qualidade de vida foi analisada por meio do questionário Ankylosing Spondylitis Quality of Life (ASQoL). Resultados: A pontuação média do ASQoL foi de 7,74 (+ 5,39). Ao analisar doenças específicas no grupo de EpA, as pontuações do ASQoL não apresentaram diferença estatisticamente significativa. Os dados demográficos mostraram piores escores de ASQoL associados ao gênero feminino (p = 0,014) e etnia negra (p < 0,001). Quanto aos sintomas clínicos, a dor na região glútea (p = 0,032), a dor cervical (p < 0,001) e a dor no quadril (p = 0,001), estiveram estatisticamente associadas a piores escores no ASQoL. O uso contínuo de fármacos anti-inflamatórios não esteroides (p < 0,001) e agentes biológicos (p = 0,044) esteve associado a escores mais elevados de ASQoL, enquanto outros medicamentos não interferiram nos escores do ASQoL. Conclusão: Nesta grande série de pacientes com EpA, o sexo feminino e a etnia negra, bem como sintomas predominantemente axiais, estiveram associados a uma qualidade de vida reduzida.

Abstract Objective: To analyze quality of life and demographic and clinical variables associated to its impairment in a large Brazilian cohort of patients with spondyloarthritis (SpA). Methods: A common protocol of investigation was applied to 1465 Brazilian patients classified as SpA according to the European Spondyloarthropaties Study Group (ESSG) criteria, attended at 29 reference centers for Rheumatology in Brazil. Clinical and demographic variables were recorded. Quality of life was analyzed through the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire. Results: The mean ASQoL score was 7.74 (± 5.39). When analyzing the specific diseases in the SpA group, the ASQoL scores did not present statistical significance. Demographic data showed worse scores of ASQoL associated with female gender (p = 0.014) and African-Brazilian ethnicity (p < 0.001). Regarding clinical symptoms, buttock pain (p = 0.032), cervical pain (p < 0.001) and hip pain (p = 0.001), were statistically associated with worse scores of ASQoL. Continuous use of nonsteroidal anti-inflammatory drugs (p < 0.001) and biologic agents (p = 0.044) were associated with higher scores of ASQoL, while the other medications did not interfere with the ASQoL scores. Conclusion: In this large series of patients with SpA, female gender and African-Brazilian ethnicity, as well as predominant axial symptoms, were associated with impaired quality of life.

https://doi.org/10.1016/j.rbr.2015.03.003 3358 downloads

15.

Proline levels, oxidative metabolism and photosynthetic pigments during in vitro growth and acclimatization of Pitcairnia encholirioides L.B. Sm. (Bromeliaceae)
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Resende, C. F.

; Braga, V. F.

; Pereira, P. F.

; Silva, C. J.

; Vale, V. F.

; Bianchetti, R. E.

; Forzza, R. C.

; Ribeiro, C.

; Peixoto, P. H. P.

Brazilian Journal of Biology

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Fev 2016, Volume 76 Nº 1 Páginas 218 - 227

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este trabalho objetivou avaliar a contribuição da prolina, do metabolismo oxidativo e dos pigmentos fotossintéticos na propagação in vitro e aclimatização de Pitcairnia encholirioides, uma bromélia criticamente ameaçada de extinção. As análises foram realizadas após 150 dias de cultivo in vitro em meio MS suplementado com 10 µM de GA3 ou 0,2 µM de ANA, 15 ou 30 g L–1 de sacarose, em tubos de ensaio que permitiam trocas gasosas ou em sistema hermeticamente vedado, e também 180 dias após aclimatização. A manutenção in vitro em frascos hermeticamente fechados, com GA3 e 15 g L–1 de sacarose apresentou efeito metabólico adverso, demonstrado pelo menor acúmulo de prolina e pigmentos fotossintéticos e também pelo aumento das atividades de enzimas antioxidantes. Após aclimatização, as diferenças para prolina e pigmentos fotossintéticos não foram mais encontradas e as atividades enzimáticas variaram de maneira desuniforme. Os resultados sugerem que o cultivo in vitro em meio com 0,2 µM de ANA e 30 g L–1 de sacarose, em tubos fechados com tampas que permitem trocas gasosas, é mais adequado para a micropropagação de P. encholirioides, proporcionando uma manutenção prolongada das culturas in vitro e plântulas com qualidade superior para o desenvolvimento ex vitro.

Abstract This study aimed to evaluate the variation in the levels of proline, oxidative metabolism and photosynthetic pigments in plants of Pitcairnia encholirioides grown in vitro under different conditions and after acclimatization. The analyses were performed after 150 days of in vitro cultivation in MS media supplemented with 10 µM GA3 or 0.2 µM NAA, sucrose at 15 or 30 g L–1, in test tubes which allowed gas exchange or in a hermetically sealed system, and 180 days after acclimatization. The in vitro maintenance in hermetically sealed flasks, with GA3 and 15 g L–1 sucrose had adverse metabolic effects, which was demonstrated by the lower proline and photosynthetic pigments accumulation and by the increase in antioxidant enzymes activities. After acclimatization, differences for proline and photosynthetic pigments were no longer found and the enzymatic activities ranged unevenly. The results suggest that the in vitro cultivation in media with 0.2 µM NAA and 30 g L–1 sucrose, in test tubes capped with closures which allowed gas exchange, is more suitable for micropropagation of P. encholirioides, providing a prolonged maintenance of in vitro cultures and plantlets with superior quality for ex vitro development.

https://doi.org/10.1590/1519-6984.19314 2157 downloads

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