ABSTRACT This article proposes to explore the very nature of the jointure formed by the following sociotechnical and historical-economic phenomena: (i) consumption as an experience of subjectivity, and (ii) the transformations that occurred in global markets over the last 40 years, where two axes are crucial: on the one hand, the digital technologies as devices for the production of virtual subjectivity, and on the other, the hybrid wars, centered on the formation and control of sensibilities and perceptions among the populations. historicaleconomic historical economic phenomena i (i subjectivity ii (ii 4 years crucial hand other wars populations

RESUMO O presente artigo propõe-se a explorar a natureza da articulação formada entre os seguintes fenômenos sociotécnicos e histórico-econômicos: (i) a vivência do consumo enquanto experiência de subjetividade, e (ii) as transformações ocorridas nos mercados globais ao longo dos últimos 40 anos, em que dois eixos nos interessam: de um lado, as tecnologias digitais como aparatos de produção de subjetividade virtualizada, e de outro, as guerras híbridas, centradas formação e controle de sensibilidades e percepções junto às populações. propõese propõe se históricoeconômicos histórico econômicos histórico-econômicos i (i ii (ii 4 anos interessam lado virtualizada outro híbridas populações

Abstract Research in the field of adult education has shown the positive impact of formal education on overall well-being. However, research on the impact of non-formal education remains scarce, particularly among older people. Given the phenomenon of an increasingly global ageing population, this ex-post facto correlational study aims to investigate how participation in non-formal education through senior or third age universities has a transformative potential on subjective well-being (SWB), self-esteem, health self-efficacy, and meaning in life for those attending such educational institutions in Portugal. Sixty seniors participated in the study, evenly split between users of a senior university (SU) and seniors who did not attend an SU or similar institution. Data were collected using internationally recognised questionnaires appropriate to the studied variables. The results show substantial effects in the SU attendance group on life satisfaction, negative affect, health self-efficacy, and the search for meaning in life compared to the control group. No significant differences were found for positive affect, as an affective component of SWB, self-esteem, or for the presence of meaning in life, with small effect sizes. The study concludes that senior universities contribute positively, particularly in the cognitive dimension of SWB, to health self-efficacy and to a dimension of meaning in life, supporting their role as contexts for active and healthy ageing and personal development. The need for further research on the topic is highlighted in order to overcome the identified limitations. wellbeing. wellbeing well being. being However nonformal non scarce people population expost ex post SWB , (SWB) selfesteem, selfesteem self esteem, esteem self-esteem selfefficacy, selfefficacy efficacy, efficacy Portugal (SU institution variables satisfaction affect sizes positively development limitations (SWB

Resumo A investigação no domínio da educação de adultos tem apontado para o efeito positivo da educação formal com relação ao bem-estar em sentido amplo, no entanto, quanto ao impacto da educação não formal os estudos são ainda escassos, particularmente com populações de idade avançada. Em face de uma população mundial cada vez mais idosa, este estudo, de tipo correlacional ex-post facto, busca investigar de que forma a participação na educação não formal, através de universidades seniores (US) ou da terceira idade, tem potencial transformador no bem-estar subjetivo (BES), autoestima, autoeficácia em saúde e no sentido da vida das pessoas que frequentam este tipo de estabelecimentos educacionais em Portugal. Participaram no estudo 60 seniores, repartidos de igual forma entre usuários de uma US e seniores que não frequentavam uma US ou outro estabelecimento similar. Os dados foram recolhidos mediante o emprego de questionários adequados às variáveis em estudo e de reconhecimento internacional. Os resultados revelam efeitos substanciais no grupo com frequência da US na satisfação com a vida e afetividade negativa, na autoeficácia em saúde e na procura de sentido na vida, em relação ao grupo de controle. Quanto à afetividade positiva, enquanto componente afetiva do BES, bem como a autoestima e a presença de sentido na vida, não foram encontradas diferenças significativas, revelando-se os tamanhos do efeito pequenos. Conclui-se pelo contributo positivo das US sobretudo na dimensão cognitiva do BES, na saúde e em uma das dimensões do sentido da vida, podendo ser consideradas contextos de envelhecimento ativo e saudável e de desenvolvimento pessoal, e salienta-se a necessidade de continuidade das investigações, no sentido de superação das limitações encontradas. bemestar estar amplo entanto escassos avançada idosa expost ex post facto (US BES , (BES) Portugal 6 similar internacional negativa controle positiva significativas revelandose revelando se pequenos Concluise Conclui pessoal salientase salienta investigações (BES

RESUMO: Este artigo apresenta um estudo experimental para verificar a viabilidade de uso da tecnologia emergente UAV no mapeamento dos pesqueiros explotados pela pesca artesanal na Baía de Sepetiba, no sul do estado do Rio de Janeiro-Brasil, visando conhecer melhor a funcionalidade e informações geradas pelo equipamento, e se os dados poderão auxiliar na melhoria do gerenciamento da pesca local e também subsidiar informações para a implantação de uma rastreabilidade simplificada para o pescado regional. A área de estudo contemplou quatro localidades sendo Ilha da Madeira, Vila Geny, Coroa Grande e Ponte Preta, todas inseridas na Baía de Sepetiba, localizada no município de Itaguaí, região sul do estado do Rio de Janeiro. O mapeamento aéreo foi realizado nos meses de setembro, outubro e novembro de 2017, entre 10h e 12h (GMT-3), utilizando um VANT Phantom 3 Professional (DJI, Shenzhen, China), registro Anac Brasil PP-011092014. A câmera integrada é uma DJI 4K Edition Sony Exmor R Modelo IMX117: 7,81 mm equipada com sensor CMOS de 6,2 mm, resolução 4000 x 3000 de 12 megapixels, com lente f/2.8 e campo de visão (FOV) de 94, possuindo uma distância focal de 14 mm. As imagens foram coletadas perpendicularmente ao plano principal. A altura de voo foi fixada em 80 m, a velocidade de voo foi determinada com base na sobreposição de 80%, dimensão da área a ser mapeada e duração da bateria. Assim, o operador utilizou uma velocidade média de voo de 25 km/h. a distância da amostra terrestre (GSD) foi de 1,20 cm/px. e foi estabelecida uma sobreposição de 80% entre as imagens para evitar possíveis falhas e lacunas de informações do ortomosaico. Para cada pesqueiro mapeado foi realizado o processamento padrão do software, que consiste em: alinhamento das fotos, criação da nuvem de pontos, criação de modelo de elevação digital, e finalmente o ortomosaico propriamente dito. Uma vez processado, os ortomosaicos foram exportados do Agis Soft Photo Scan Professional para o Google Earth (Google Inc.), onde é possível fazer uma avaliação mais abrangente dos pesqueiros de uma maneira muito mais prática e rápida. Foram realizados um total de quatro voos, um para cada área de estudo, com duração média de 10 minutos cada. Como resultado, a tecnologia mostrou-se viável de aplicação, uma vez que possibilitou identificar e mapear as áreas definidas para nesta pesquisa, gerando dados como distância e características do local, que poderão ser utilizados para rastrear o pescado capturado e desembarcado, além de possibilitar o monitoramento das embarcações e da pesca e assim, aprimorar o gerenciamento da pesca local. RESUMO Sepetiba JaneiroBrasil, JaneiroBrasil Janeiro Brasil, Janeiro-Brasil equipamento regional Madeira Geny Preta Itaguaí setembro 2017 h GMT3, GMT3 GMT , (GMT-3) DJI, (DJI Shenzhen China, China China) PP011092014. PP011092014 PP 011092014. 011092014 PP-011092014 K IMX117 IMX 781 7 81 7,8 62 6 2 6, 400 300 1 megapixels f28 f 8 f/2. FOV (FOV 94 principal m bateria Assim kmh km km/h GSD (GSD 120 20 1,2 cmpx cm px cm/px software fotos pontos digital dito processado Inc., Inc Inc. Inc.) rápida voos resultado mostrouse mostrou aplicação pesquisa desembarcado assim 201 (GMT-3 PP01109201 01109201 PP-01109201 IMX11 78 7, 40 30 f2 f/2 9 1, (GMT- PP0110920 0110920 PP-0110920 IMX1 4 f/ (GMT PP011092 011092 PP-011092 PP01109 01109 PP-01109 PP0110 0110 PP-0110 PP011 011 PP-011 PP01 01 PP-01 PP0 0 PP-0 PP-

ABSTRACT: This article presents an experimental study to verify the feasibility of using the emerging UAV technology in the mapping of fishing grounds exploited by artisanal fishing in Sepetiba Bay, in the south of the state of Rio de Janeiro-Brazil, aiming to better understand the functionality and information generated by the equipment, and whether the data can help improve local fisheries management and also provide information for the implementation of simplified traceability for regional fish. The study area included four locations, Ilha da Madeira, Vila Geny, Coroa Grande and Ponte Preta, all located in Sepetiba Bay, located in the municipality of Itaguaí, in the southern region of the state of Rio de Janeiro. The aerial mapping was carried out in September, October and November 2017, between 10 am and 12 pm (GMT-3), employing a Phantom 3 Professional UAV (DJI, Shenzhen, China), Anac Brasil registration number PP-011092014. The onboard camera a DJI 4K Edition Sony Exmor R Model IMX117: 7.81mm equipped with a CMOS sensor dimension of 6.2 mm, 4000 x 3000 12 megapixel resolution, with an f/2.8 lens and field of view (FOV) of 94, having a focal length of 14mm. Images were collected perpendicularly to the main plan. Flight height was set at 80 m, flight speed was determined based on the overlap of 80%, dimension of area to be mapped, and battery life. Hence, the operator utilized a average flight speed of 25 km/h. ground sample distance (GSD) was 1.20 cm/px. and an overlap of 80% between images was established to avoid possible failures and orthomosaic information gaps. For each fishery mapped, standard software processing was carried out, which consists of: aligning the photos, creating a point cloud, creating a digital elevation model, and finally the orthomosaic itself. Once processed, the orthomosaics were exported from Agis Soft Photo Scan Professional to Google Earth (Google Inc.), where it is possible to make a more comprehensive assessment of fisheries in a much more practical and faster way. A total of four flights were carried out, one for each study area, averaging 10 minutes each. As a result, the technology proved to be viable to apply, since it made it possible to identify and map the areas defined for this research, generating data such as distance and, characteristics of the place, which could be used to track the fish caught and landed, in addition to enabling the monitoring of vessels and fishing, and thus improve the management of local fisheries. ABSTRACT Bay JaneiroBrazil, JaneiroBrazil Janeiro Brazil, Brazil Janeiro-Brazil equipment locations Madeira Geny Preta Itaguaí September 2017 1 GMT3, GMT3 GMT , (GMT-3) DJI, (DJI Shenzhen China, China China) PP011092014. PP011092014 PP 011092014. 011092014 PP-011092014 K IMX117 IMX 781mm mm 7 81mm 62 6 2 6. 400 300 resolution f28 f 8 f/2. FOV (FOV 94 14mm plan m mapped life Hence kmh km h km/h GSD (GSD 120 20 1.2 cmpx cm px cm/px gaps photos cloud model itself processed Inc., Inc Inc. Inc.) way result apply research place landed 201 (GMT-3 PP01109201 01109201 PP-01109201 IMX11 40 30 f2 f/2 9 1. (GMT- PP0110920 0110920 PP-0110920 IMX1 4 f/ (GMT PP011092 011092 PP-011092 PP01109 01109 PP-01109 PP0110 0110 PP-0110 PP011 011 PP-011 PP01 01 PP-01 PP0 0 PP-0 PP-

Abstract Associations between the WNT5A rs566926 variant and non-syndromic orofacial cleft (NSOC) have been reported in different populations. Objective This study aimed to investigate the role of the rs566926 single nucleotide polymorphism (SNP) in WNT5A and its interactions with SNPs in BMP4, FGFR1, GREM1, MMP2, and WNT3 in the occurrence of NSOC in a Brazilian population. Methodology A case-control genetic association study was carried out involving participants from four regions of Brazil, totaling 801 patients with non-syndromic cleft lip with or without cleft palate (NSCL±P), 273 patients with cleft palate only (NSCPO), and 881 health volunteers without any congenital condition (control). Applying TaqMan allelic discrimination assays, we evaluated WNT5A rs566926 in an ancestry-structured multiple logistic regression analysis, considering sex and genomic ancestry as covariates. Interactions between rs566926 and variants in genes involved in the WNT5A signaling pathway (BMP4, FGFR1, GREM1, MMP2, and WNT3) were also explored. Results WNT5A rs566926 was significantly associated with an increased risk of NSCL±P, particularly due to a strong association with non-syndromic cleft lip only (NSCLO), in which the C allele increased the risk by 32% (OR: 1.32, 95% CI: 1.04–1.67, p=0.01). According to the proportions of European and African genomic ancestry, the association of rs566926 reached significant levels only in patients with European ancestry. Multiple interactions were detected between WNT5A rs566926 and BMP4 rs2071047, GREM1 rs16969681 and rs16969862, and FGFR1 rs7829058. Conclusion The WNT5A rs566926 polymorphism was associated with NSCL±P, particularly in individuals with NSCLO and high European ancestry. Epistatic interactions involving WNT5A rs566926 and variants in BMP4, GREM1, and FGFR1 may contribute to the risk of NSCL±P in the Brazilian population. WNTA WNT rs rs56692 nonsyndromic non syndromic (NSOC populations SNP (SNP BMP FGFR GREM MMP2 MMP population casecontrol case control Brazil 80 NSCLP , NSCL P (NSCL±P) 27 NSCPO, NSCPO (NSCPO) 88 control. . (control) assays ancestrystructured structured analysis covariates (BMP4 explored NSCLO, (NSCLO) 32 OR (OR 132 1 1.32 95 CI 104167 04 67 1.04–1.67 p=0.01. p001 p p=0.01 0 01 p=0.01) rs2071047 rs1696968 rs16969862 rs7829058 rs5669 8 (NSCL±P 2 (NSCPO (control (BMP (NSCLO 3 13 1.3 9 10416 6 1.04–1.6 p00 p=0.0 rs207104 rs169696 rs1696986 rs782905 rs566 1. 1041 1.04–1. p0 p=0. rs20710 rs16969 rs169698 rs78290 rs56 104 1.04–1 p=0 rs2071 rs1696 rs7829 rs5 10 1.04– p= rs207 rs169 rs782 1.04 rs20 rs16 rs78 1.0 rs2 rs1 rs7

Resumo Introdução: O câncer cervical está associado com a infecção persistente pelo HPV (human papiloma virus) de alto risco e causa cerca de 265 mil mortes todos os anos no mundo, tornando-se um importante problema de saúde pública. Objetivo: Descrever o perfil epidemiológico, história clínica e achados citológicos de 55 mulheres infectadas com HPV vivendo em áreas remotas no Amazonas, Brasil. Método: Obtiveram-se as amostras por autocoleta, utilizando-se a escova Rovers® Evalyn® para detecção do HPV por meio da técnica de PCR (polymerase chain reaction). Realizou-se o exame citológico por citologia em meio líquido. Resultados: A média de idade das participantes foi de 35 anos de idade (DP=14). A maioria das mulheres apresentou baixa ou nenhuma escolaridade (52,7%), vivia em uma relação estável com um parceiro (74,5) e tinha de três a cinco filhos (32,5%). Observou-se o uso inconsistente de preservativo pela maioria das participantes (“nunca 34,5% e “às vezes” 41,8%). O exame citopatológico mostrou que 14 mulheres (25,4%) tinham alterações citológicas: 7 Ascus (50,0%), 5 L-SIL (35,7%) e 2 H-SIL (14,3%). Conclusões: Uma vez que as lesões cervicais são causadas pela infecção persistente pelo HPV, é importante que programas de prevenção do CC usem alternativas eficazes para acompanhar mulheres HPV positivas vivendo em áreas remotas. Introdução human virus 26 mundo tornandose tornando se pública Objetivo epidemiológico Amazonas Brasil Método Obtiveramse Obtiveram autocoleta utilizandose utilizando Rovers Evalyn polymerase reaction. reaction . reaction) Realizouse Realizou líquido Resultados 3 DP=14. DP14 DP DP=14 (DP=14) 52,7%, 527 52,7% , 52 (52,7%) 74,5 745 74 (74,5 32,5%. 325 32,5% 32 (32,5%) Observouse Observou nunca 345 34 34,5 às vezes 41,8%. 418 41,8% 41 8 41,8%) 1 25,4% 254 25 4 (25,4% citológicas 50,0%, 500 50,0% 50 0 (50,0%) LSIL L SIL 35,7% 357 (35,7% HSIL H 14,3%. 143 14,3% (14,3%) Conclusões DP1 DP=1 (DP=14 52,7 (52,7% 74, (74, 32,5 (32,5% 34, 41,8 25,4 (25,4 50,0 (50,0% 35,7 (35,7 14,3 (14,3% DP= (DP=1 52, (52,7 (74 32, (32,5 41, 25, (25, 50, (50,0 35, (35, 14, (14,3 (DP= (52, (7 (32, (25 (50, (35 (14, (DP (52 ( (32 (2 (50 (3 (14 (5 (1

Abstract Background: Cervical cancer (CC) is associated with persistent high-risk human papillomavirus (HPV) infection and it causes about 265,000 deaths per year worldwide, thus becoming an important public health problem. Objective: This study aimed to describe the epidemiological profile, clinical history, and cytological findings of 55 women infected with HPV living in remote areas in Amazonas, Brazil. Method: The samples were obtained by self-collection using the Rovers® Evalyn® Brush for HPV detection through PCR. The cytological examination was performed by liquid-based cytology. Results: The mean age of participants was 35 years (SD=14). Most of the women presented low or no schooling (52.7%), lived in stable relationship with a partner (74.5%), and had three to five children (32.7%). Inconsistent use of condoms by most of the participants (“never” — 34.5% and “sometimes” — 41.8%) was observed. Cytopathological examinations showed that 14 (25.4%) women had cytological alterations: 7 atypical squamous cells of undetermined significance (50.0%), 5 low-grade squamous intraepithelial lesions (35.7%), and 2 high-grade squamous intraepithelial lesions (14.3%). Conclusion: As cervical lesions have been caused by persistent HPV infection over the years, CC Prevention Programs use effective strategies to follow up on HPV-positive women living in remote areas. Background (CC highrisk high risk (HPV 265000 265 000 265,00 worldwide problem Objective profile history Amazonas Brazil Method selfcollection self collection Rovers Evalyn PCR liquidbased liquid based cytology Results 3 SD=14. SD14 SD SD=14 . (SD=14) 52.7%, 527 52.7% , 52 (52.7%) 74.5%, 745 74.5% 74 (74.5%) 32.7%. 327 32.7% 32 (32.7%) never (“never 345 34 34.5 sometimes “sometimes 41.8% 418 41 8 observed 1 25.4% 254 25 4 (25.4% alterations 50.0%, 500 50.0% 50 0 (50.0%) lowgrade grade 35.7%, 357 35.7% (35.7%) highgrade 14.3%. 143 14.3% (14.3%) Conclusion HPVpositive positive 26500 26 00 265,0 SD1 SD=1 (SD=14 52.7 (52.7% 74.5 (74.5% 32.7 (32.7% 34. 41.8 25.4 (25.4 50.0 (50.0% 35.7 (35.7% 14.3 (14.3% 2650 265, SD= (SD=1 52. (52.7 74. (74.5 32. (32.7 41. 25. (25. 50. (50.0 35. (35.7 14. (14.3 (SD= (52. (74. (32. (25 (50. (35. (14. (SD (52 (74 (32 (2 (50 (35 (14 (5 (7 (3 ( (1

Abstract Autologous blood transfusion can be achieved through different techniques, including by the patient donating blood before surgery (pre-deposit), collecting blood from the patient immediately before the operation and replacing the volume with colloids or plasma expanders (acute normovolemic hemodilution) or through the salvage of lost blood, during or immediately after surgery, and its retransfusion after washing (intraoperative or postoperative recovery). We will focus on the two methods used intraoperatively that are of fundamental importance in the management and conservation of the patient's own blood. techniques predeposit, predeposit pre deposit , (pre-deposit) acute hemodilution intraoperative recovery. recovery . recovery) patients s (pre-deposit

Abstract Understanding the physiological concepts of oxygen delivery is essential to discern the mechanisms that influence its increase, reduction or maintenance in the body. This text explores the different mechanisms that help maintain oxygen delivery even in the face of reduced hemoglobin levels. Adequate oxygen delivery ensures tissue and metabolic balance, which is crucial to avoid harmful consequences such as metabolic acidosis and cellular dysoxia. The complex interaction between variables such as cardiac output, hemoglobin and heart rate (HR) plays a fundamental role in maintaining oxygen delivery, allowing the body to temporarily adjust to situations of anemia or high metabolic demand. It is important to emphasize that blood transfusions should not be based on fixed values, but rather on individual metabolic needs. Strategies to reduce myocardial consumption and monitor macro and micro hemodynamics help in making rational decisions. Individualizing treatment and considering factors such as blood viscosity in relation to the benefits of transfusion are increasingly relevant to optimize therapy and minimize risks, especially in complex clinical scenarios, such as neurocritical patients and trauma victims. increase levels balance dysoxia output HR (HR demand values needs decisions risks scenarios victims

Abstract Hemostasis plays a critical role in surgical procedures and is essential for a successful outcome. Advances in hemostatic agents offer new approaches to controlling bleeding thereby making surgeries safer. The appropriate choice of these agents is crucial. Volume replacement, another integral part of Patient Blood Management (PBM), maintains adequate tissue perfusion, preventing cellular damage. Individualization in fluid administration is vital with the choice between crystalloids and colloids depending on each case. Colloids, unlike crystalloids, increase oncotic pressure, contributing to fluid retention in the intravascular space. Understanding these aspects is essential to ensure safe and effective surgery, minimizing complications related to blood loss and maintaining the patient's hemodynamic status. outcome safer crucial replacement PBM, PBM , (PBM) perfusion damage case Colloids pressure space surgery patients patient s status (PBM

Abstract Postoperative anemia is a complex clinical issue that requires attention due to its ramifications on the patient's recovery and prognosis. Originating from multiple determinants, such as intraoperative blood loss, hemolysis, nutritional deficiencies, systemic inflammation and impact on the bone marrow, postoperative anemia has varied and often challenging presentations. Patients undergoing major surgical procedures, in particular, are susceptible to developing anemia due to the considerable associated blood loss. Accurate diagnosis plays a crucial role in the approach, requiring meticulous hematological analysis, including hemoglobin, hematocrit and reticulocyte count, as well as an in-depth investigation of the underlying causes. An additional challenge arises in the form of the excessive practice of phlebotomy during hospitalization for clinical monitoring. Although it is essential to assess the progression of anemia, frequent removal of blood may contribute to iatrogenic anemia, further delaying recovery and possibly increasing susceptibility to infection. patients patient s prognosis determinants loss hemolysis deficiencies marrow presentations procedures particular approach analysis hemoglobin count indepth depth causes monitoring infection

Abstract Anemia is a pathological condition in which the hemoglobin and red blood cell mass decrease; it is mainly defined by the concentration of hemoglobin in the blood. The World Health Organization guidelines establish specific values to define anemia in different population groups. Early detection of anemia can also be a valuable indicator of underlying medical conditions. Clinical studies have explored the relationship between perioperative anemia and morbidity, highlighting the need for more judicious therapeutic strategies, such as the use of Patient Blood Management, which aims to prevent and treat anemia in a personalized and effective way. Patient Blood Management emerges as a promising approach to dealing with anemia, recognizing that its correction through transfusion always carries risks and that personalized prevention and treatment can offer better outcomes for patients. decrease groups conditions morbidity strategies way patients

Abstract Hemostasis plays a critical role in surgical procedures and is essential for a successful outcome. Advances in hemostatic agents offer new approaches to controlling bleeding thereby making surgeries safer. The appropriate choice of these agents is crucial. Volume replacement, another integral part of Patient Blood Management (PBM), maintains adequate tissue perfusion, preventing cellular damage. Individualization in fluid administration is vital with the choice between crystalloids and colloids depending on each case. Colloids, unlike crystalloids, increase oncotic pressure, contributing to fluid retention in the intravascular space. Understanding these aspects is essential to ensure safe and effective surgery, minimizing complications related to blood loss and maintaining the patient's hemodynamic status. outcome safer crucial replacement PBM, PBM , (PBM) perfusion damage case Colloids pressure space surgery patients patient s status (PBM

Abstract The use of strategies to reduce blood loss and transfusions is essential in the treatment of surgical patients, including in complex cardiac surgeries and those that use cardiopulmonary bypass. Antifibrinolytics, such as epsilon-aminocaproic acid (EACA) and tranexamic acid (TXA), are widely used in these procedures, as well as in other types of surgeries. These medicines are included in the World Health Organization (WHO) list of ‘essential medicines’. Scientific evidence demonstrates the effectiveness of EACA in reducing bleeding and the need for transfusions in heart surgery. EACA is highly recommended for use in heart surgery by the American Society of Anesthesiology Task Force on Perioperative Blood Management. Regarding the safety of EACA, there is no robust evidence of any significant thrombotic potential. TXA has also been shown to be effective in reducing the use of blood transfusions in cardiac and non-cardiac surgeries and is considered safer than other antifibrinolytic agents. There is no evidence of any increased risk of thromboembolic events with TXA, but doses greater than 2 g per day have been associated with an increased risk of seizures. It is also important to adjust the dose in patients with renal impairment. In conclusion, antifibrinolytics, such as EACA and TXA, are effective in reducing blood loss and transfusion use in cardiac and non-cardiac surgeries, without causing serious adverse effects. bypass Antifibrinolytics epsilonaminocaproic epsilon aminocaproic (EACA , (TXA) procedures WHO (WHO medicines. . medicines’ Management potential noncardiac non agents seizures impairment conclusion antifibrinolytics effects (TXA

Abstract The management of major bleeding is a critical aspect of modern healthcare and it is imperative to emphasize the importance of applying Patient Blood Management (PBM) principles. Although transfusion support remains a vital component of bleeding control, treating severe bleeding goes beyond simply replacing lost blood. A more comprehensive, multidisciplinary approach is essential to optimize patient outcomes and minimize the risks associated with excessive transfusions. PBM (PBM principles control blood comprehensive transfusions

RESUMEN Objetivo: Evaluar el impacto de la intervención educativa en la aparición de factores que interfieren en el aporte calórico-proteico de pacientes críticos y no críticos sometidos a terapia nutricional enteral. Método: Se trata de una intervención, un experimento de campo sin grupo de control, realizado en un hospital universitario en Juiz de Fora, Minas Gerais, Brasil. Se realizaron tres ciclos formativos con profesionales de enfermería durante 57 semanas, abarcando los mismos contenidos. Los datos recopilados se dividieron en períodos de preintervención e intervención. Se analizó la interferencia en el aporte calórico-proteico a partir de la evaluación de los días con incumplimiento de la provisión nutricional y la ocurrencia de factores que llevaron a las no conformidades. Resultados: Después de las intervenciones hubo una reducción significativa (p < 0,05) del número de días de incumplimiento e inadecuados (suministro nutricional < 80%), la frecuencia de aparición de factores de interferencia y no conformidades provocadas por la no ejecución del protocolo de vómitos. Conclusión: La intervención educativa resultó una estrategia efectiva para incrementar la calidad de la terapia evaluada, especialmente a partir del quinto día de terapia nutricional enteral. Objetivo calóricoproteico calórico proteico enteral Método control Fora Gerais Brasil 5 semanas contenidos Resultados p 0,05 005 0 05 suministro 80%, 80 80% , 80%) vómitos Conclusión evaluada 0,0 00 8 0,

ABSTRACT Objective: To evaluate the impact of educational intervention on the occurrence of factors that interfere with the caloric-protein supply to critical and non-critical patients undergoing enteral nutritional therapy. Method: This is an intervention, a field experiment without a control group, carried out in a teaching hospital in Juiz de Fora, Minas Gerais, Brazil. Three training cycles were carried out with nursing professionals over 57 weeks, covering the same content. The data collected were divided into pre-intervention and intervention periods. Interference in caloric-protein support was analyzed based on the evaluation of days with non-conforming nutritional supply and the occurrence of factors that led to non-conformities. Results: Following interventions, there was a significant reduction (p < 0.05) in the number of non-conforming and inadequate days (nutritional supply < 80%), the frequency of occurrence of interfering factors and non-conformities caused by failure to follow the vomiting protocol. Conclusion: The educational intervention was an effective strategy to increase the quality of the therapy evaluated, especially from the fifth day of enteral nutritional therapy onwards. Objective caloricprotein caloric protein noncritical non Method group Fora Gerais Brazil 5 weeks content preintervention pre periods nonconforming conforming nonconformities. nonconformities conformities. conformities Results interventions p 0.05 005 0 05 80%, 80 80% , 80%) protocol Conclusion evaluated onwards 0.0 00 8 0.

RESUMO Objetivo: Avaliar o impacto de intervenção educativa na ocorrência de fatores que interferem na oferta calórica-proteica aos pacientes críticos e não críticos em terapia nutricional enteral. Método: Trata-se de uma intervenção, do tipo experimento de campo sem grupo controle, realizada em um hospital de ensino de Juiz de Fora, Minas Gerais, Brasil. Foram realizados 3 ciclos de capacitações com profissionais de enfermagem ao longo de 57 semanas, com abordagem dos mesmos conteúdos. Os dados coletados foram divididos em período pré-intervenção e de intervenção. A interferência no suporte calórico-proteico foi analisada a partir da avaliação dos dias com oferta nutricional não conforme e da ocorrência dos fatores que levaram às não conformidades. Resultados: Após as intervenções, houve redução significativa (p < 0,05) do número de dias não conformes e inadequados (oferta nutricional < 80%), da frequência de ocorrência dos fatores de interferência e das inconformidades ocasionadas pela não execução do protocolo de vômito. Conclusão: A intervenção educativa foi uma estratégia efetiva para aumentar a qualidade da terapêutica avaliada, especialmente a partir do quinto dia de terapia nutricional enteral. Objetivo calóricaproteica calórica proteica enteral Método Tratase Trata se controle Fora Gerais Brasil 5 semanas conteúdos préintervenção pré calóricoproteico calórico proteico conformidades Resultados intervenções p 0,05 005 0 05 80%, 80 80% , 80%) vômito Conclusão avaliada 0,0 00 8 0,

ABSTRACT This study aimed to assess the growth performance of bullfrog (Aquarana catesbeiana) tadpoles subjected to different management practices and diets. Two distinct feeding management strategies were evaluated: broadcast feeding and the use of a trough. Regarding the diet, two formulations were tested: the first involved feed with 28% crude protein (CP) for the initial 30 days, followed by feed with 36% CP for the subsequent 30 days; the second treatment consisted of a commercial feed designed for tropical carnivorous fish, containing 40% CP, administered throughout the experimental period (60 days). The experiment was conducted in sixteen 30-L containers, each undergoing a daily water renewal of 200% of its volume, and tadpoles were stocked at a density of one tadpole/L (0.081±0.075 g initial weight). Growth performance was evaluated. The experimental design was factorial (2 × 2) with four replicates. Data were analyzed using analysis of variance and Tukey’s test (α = 0.05). Tadpoles fed the commercial feed outperformed (final weight of 3.329 g (FW), feed conversion (FC) of 1.423 g/g, and protein efficiency rate (PER) of 1.578 g/g) those fed the experimental diets in all growth performance parameters except for PER, whose best results were achieved with the experimental diets (FW of 2.708 g; FC of 1.579 g/g, and PER of 1.880 g/g). Regarding management practices, the use of a trough yielded (FC of 1.409 g/g) superior outcomes compared with the traditional method (FC of 1.579 g/g); therefore, the combination of a trough and the commercial feed regimen demonstrated the best results. Aquarana catesbeiana evaluated diet tested 28 (CP 3 days 36 fish 40 60 (6 days. . days) 30L L containers 200 volume tadpoleL tadpole 0.081±0.075 00810075 0 081 075 (0.081±0.07 weight. weight) 2 ( replicates Tukeys Tukey s α 0.05. 005 0.05 05 0.05) final 3329 329 3.32 FW, FW , (FW) 1423 1 423 1.42 gg g/g (PER 1578 578 1.57 2708 708 2.70 1579 579 1880 880 1.88 g/g. 1409 409 1.40 therefore 4 6 20 0.081±0.07 0081007 08 07 (0.081±0.0 00 0.0 332 32 3.3 142 42 1.4 157 57 1.5 270 70 2.7 188 88 1.8 140 0.081±0.0 008100 (0.081±0. 0. 33 3. 14 1. 15 5 27 7 2. 18 8 0.081±0. 00810 (0.081±0 0.081±0 0081 (0.081± 0.081± 008 (0.081 0.081 (0.08 0.08 (0.0 (0. (0