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The landscape of biomedical research funding in Brazil: a current overview Brazil
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Gomes, Cristiano M.
; Marchini, Giovanni
; Bessa Júnior, Jose de
; Carvalhal, Gustavo
; Caldeira, Marina P. R.
; Saldiva, Paulo Hilario
; Krieger, Jose Eduardo
; Agena, Fabiana
; Reis, Sabrina
; Paschoal, Candice
; Froes, Milena
; Srougi, Miguel
; Nahas, William C.
; Favorito, Luciano A.
.
ABSTRACT Objective: The objective of this narrative review is to discuss the current state of research funding in Brazil. Materials and Methods: This study is based on the most recent edition of the course Funding for Research and Innovation in the University of Sao Paulo School of Medicine which was a three-day course with 12 hours of instruction. The course brought together leading experts in the field to comprehensively discuss the current state of research funding in Brazil. Each speaker provided a presentation on a specific topic related to research funding. After the workshop, speakers assembled relevant topics in this manuscript. Results: collaborative research is critical for securing research funding. It optimizes proposal competitiveness, amplifies societal impact, and manages risks effectively. As such, fostering and supporting these collaborations is paramount for both researchers and funding agencies. To maintain the highest integrity in research, investigators involved in these collaborations must disclose any relationships that could potentially influence the outcomes or interpretation of their projects. Conclusions: In Brazil, the mainstay of research funding stems from public entities, with agencies such as CNPq, CAPES, and state bodies like FAPESP, FAPERJ, FAPEMIG and others at the forefront. Concurrently, industry funding offers viable pathways, especially through industry-sponsored studies, investigator-led projects, and collaborative initiatives. The Brazilian funding landscape is further enriched by innovative platforms, including crowdfunding and the contributions of institutions like the Serrapilheira Institute. Internationally, esteemed organizations such as the National Institutes of Health (NIH) and the Bill & Melinda Gates Foundation stand out as potential funders. Objective Brazil Methods threeday three day 1 instruction workshop manuscript Results competitiveness impact effectively projects Conclusions entities CNPq CAPES FAPESP FAPERJ forefront Concurrently pathways industrysponsored sponsored studies investigatorled investigator led initiatives platforms Institute Internationally NIH (NIH funders
2.
The impact of a physical exercise program on quality of life, fatigue, physical performance, and level of physical activity in patients with cancer life fatigue performance
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Reis, Fabiana
; Pereira, Ana Carolina Caporali
; Almeida, Elisângela Pinto Marinho de
; Cecatto, Rebeca Boltes
; Brito, Christina May Moran de
.
Revista da Associação Médica Brasileira
- Métricas do periódico
SUMMARY OBJECTIVE: Increasing evidence suggests that exercise programs are of great value in the rehabilitation and survivorship of patients with cancer. However, challenges remain regarding maintaining patients more physically active. This study aimed to evaluate the impact of a supervised exercise program on quality of life, fatigue, physical performance, and levels of physical activity of patients with cancer. METHODS: An observational longitudinal study, with a 1-year prospective follow-up, was developed. SETTING: This is a university-based outpatient rehabilitation program in a high-complexity cancer care center in Sao Paulo. RESULTS: After the program, patients showed a significant gain in quality of life (p<0.0001), physical performance (p<0.0001), and improvement in fatigue (p<0.0001). After 12 months, 81.1% of the patients remained active, and only 4.5% declared themselves to be sedentary. CONCLUSION: The results of this study confirm that exercise programs are an important tool in the rehabilitation of patients with cancer and that an initial supervised exercise program, in combination with follow-ups, can help increase the levels of physical activity of this population. CLINICAL REHABILITATION IMPACT: This study provides additional information on the outcomes that are expected with the provision of a supervised physical exercise program in the rehabilitation care of patients with cancer and that additional follow-ups could further benefit this population. OBJECTIVE However active METHODS 1year year 1 followup, followup follow up, up follow-up developed SETTING universitybased university based highcomplexity high complexity Paulo RESULTS p<0.0001, p00001 p p<0.0001 , 0 0001 (p<0.0001) p<0.0001. . months 811 81 81.1 45 4 5 4.5 sedentary CONCLUSION followups, followups ups, ups population IMPACT p0000 p<0.000 000 (p<0.0001 8 81. 4. p000 p<0.00 00 (p<0.000 p00 p<0.0 (p<0.00 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p
3.
Cross-cultural adaptation of the Impact on Participation and Autonomy questionnaire for Brazil for people with spinal cord injury Crosscultural Cross cultural
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Andrade, Valéria Sousa de
; Amaral, Maíra Ferreira do
; Reis, Roberta Alvarenga
; Castro, Fabiana Faleiros
; Santos, Claudia Benedita dos
.
Resumo Introdução Pessoas com condições crônicas e/ou deficiências podem apresentar impacto no exercício de sua autonomia e participação, com prejuízo para o desempenho em atividades diárias. A mensuração desses construtos deve considerar o modelo biopsicossocial. Objetivo Adaptar transculturalmente o questionário Impact on Participation and Autonomy para pessoas com lesão medular para uso no contexto brasileiro. Método Estudo metodológico desenvolvido em centro de reabilitação de um hospital público brasileiro envolvendo pessoas com lesão medular maiores de 18 anos. Foram seguidos procedimentos padronizados internacionalmente para o processo de tradução-retrotradução e avaliação dos aspectos semânticos do questionário. Resultados Foi realizada a tradução do questionário por dois profissionais independentes, seguida da síntese das traduções. Posteriormente, foram averiguadas as equivalências semântica, cultural, idiomática e conceitual pelo Comitê de Especialistas, sucedida pela retrotradução e envio ao autor do questionário. Participaram da avaliação semântica 18 pessoas com lesão medular com idade média de 38,8 anos (DP = 13,1). Os participantes apontaram que a versão final estava boa ou muito boa (n=17), sendo as questões de fácil compreensão (n=11), com itens muito importantes para o estado de saúde/doença (n=14) e que não havia dificuldades para utilizar as categorias de resposta (n=11). Conclusão A versão adaptada do questionário Impact on Participation and Autonomy para o Brasil foi facilmente compreendida, aceita e considerada relevante pelos participantes. Após a validação, o questionário poderá ser incluído na prática clínica de reabilitação de pessoas com lesão medular, considerando os aspectos biopsicossociais. eou participação diárias biopsicossocial 1 traduçãoretrotradução independentes traduções Posteriormente cultural Especialistas 388 38 8 38, DP 13,1. 131 13,1 . 13 13,1) n=17, n17 n n=17 , 17 (n=17) n=11, n11 n=11 11 (n=11) saúdedoença saúde doença n=14 n14 14 (n=14 n=11. compreendida validação biopsicossociais 3 13, n1 n=1 (n=17 (n=11 (n=1 n= (n= (n
Abstract Introduction People with chronic conditions and/or disabilities can have an impact on their autonomy and participation, impairing their performance in daily activities. The measurement of these constructs should consider the biopsychosocial model. Objective To cross-culturally adapt the Impact on Participation and Autonomy questionnaire for people with spinal cord injury for use in the Brazilian context. Method Methodological study carried out in a rehabilitation center of a Brazilian public hospital involving people with spinal cord injury aged 18 and over. Internationally standardized procedures were followed for the translation-backtranslation process and evaluation of the semantic aspects of the questionnaire. Results The questionnaire was translated by two independent professionals, followed by a synthesis of the translations. The semantic, cultural, idiomatic and conceptual equivalences were then verified by the Expert Committee, followed by back-translation, which was sent to the author of the questionnaire. Eighteen people with spinal cord injury took part in the cognitive debriefing, with an average age of 38.8 years (SD = 13.1). Participants pointed out that the final version was good or very good (n=17), the questions were easy to understand (n=11), with items that are very important for the state of health/illness (n=14) and that there were no difficulties using the response categories (n=11). Conclusion The Brazilian version of the Impact on Participation and Autonomy questionnaire was easily understood, accepted and considered relevant by the participants. After validation, the questionnaire could be included in the clinical practice of rehabilitating people with spinal cord injury considering biopsychosocial aspects. andor participation activities model crossculturally cross culturally context 1 over translationbacktranslation translation backtranslation professionals translations cultural Committee backtranslation, back translation, back-translation debriefing 388 38 8 38. SD 13.1. 131 13.1 . 13 13.1) n=17, n17 n n=17 , 17 (n=17) n=11, n11 n=11 11 (n=11) healthillness health illness n=14 n14 14 (n=14 n=11. understood participants validation 3 13. n1 n=1 (n=17 (n=11 (n=1 n= (n= (n
4.
Wilson disease: the diagnostic challenge and treatment outcomes in a series of 262 cases disease 26 2
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Deguti, Marta Mitiko
; Araujo, Fabiana Cordeiro
; Terrabuio, Débora Raquel Benedita
; Araujo, Thiago Ferreira
; Barbosa, Egberto Reis
; Porta, Gilda
; Cançado, Eduardo Luiz Rachid
.
Resumo Antecedentes A doença de Wilson (DW) é um distúrbio autossômico recessivo caracterizado por acúmulo de cobre lesivo aos órgãos. O diagnóstico precoce é dificultado pela raridade e diversidade de apresentações. Objetivo Descrever características ao diagnóstico e resposta ao tratamento em uma coorte de DW. Métodos Análise retrospectiva de 262 casos de DW quanto à apresentação clínica, exames complementares, genotipagem e resposta ao tratamento. Resultados Os sintomas surgiram em uma média aos 17,4 (7–49) anos, e os pacientes foram acompanhados por uma média de 9,6 (0–45) anos. Os pacientes apresentaram principalmente formas hepáticas (36,3%), neurológicas (34,7%) e neuropsiquiátricas (8,3%). Outras apresentações foram hematológicas, renais e musculoesqueléticas. Apenas 16,8% eram assintomáticos. Anéis de Kayser-Fleischer ocorreram em 78,3% dos pacientes, hipoceruloplasminemia em 98,3%, e cuprúria elevada/24h em 73,0%, com aumento após D-penicilamina em 54,0%. Mutações do gene ATP7B foram detectadas em 84,4% dos alelos pesquisados. A ressonância magnética cerebral mostrou alterações em gânglios da base em 77,7% dos pacientes. O tratamento com D-penicilamina foi a escolha inicial em 93,6% dos 245 casos e foi trocado em 21,1% devido a efeitos adversos. Terapias de segunda linha foram zinco e trientina. A resposta terapêutica não diferiu significativamente entre os medicamentos (p= 0,2). Nove pacientes receberam transplante hepático e 82 faleceram. Conclusão O diagnóstico da DW ainda ocorre em estágios tardios, e as opções terapêuticas são limitadas. A DW deve ser considerada precocemente no diagnóstico diferencial de pessoas com menos de 40 anos com manifestações compatíveis. É necessário incorporar na prática clínica a genotipagem do ATP7B e alternativas terapêuticas à penicilamina. (DW órgãos 26 complementares 174 17 4 17, 7–49 749 7 49 (7–49 96 9 6 9, 0–45 045 0 45 (0–45 36,3%, 363 36,3% , 36 3 (36,3%) 34,7% 347 34 (34,7% 8,3%. 83 8,3% . 8 (8,3%) hematológicas musculoesqueléticas 168 16 16,8 assintomáticos KayserFleischer Kayser Fleischer 783 78 78,3 983 98 98,3% elevada24h elevadah elevada 24h h 730 73 73,0% Dpenicilamina D penicilamina 540 54 54,0% ATPB ATP B 844 84 84,4 pesquisados 777 77 77,7 936 93 93,6 24 211 21 1 21,1 adversos trientina p= p (p 0,2. 02 0,2 2 0,2) faleceram tardios limitadas compatíveis 7–4 74 (7–4 0–4 04 (0–4 36,3 (36,3% 34,7 (34,7 8,3 (8,3% 16, 78, 98,3 73,0 5 54,0 84, 77, 93, 21, 0, 7– (7– 0– (0– 36, (36,3 34, (34, 8, (8,3 98, 73, 54, (7 (0 (36, (34 (8, ( (36 (3 (8
Abstract Background Wilson disease (WD) is an autosomal recessive disorder that leads to organ toxicity due to copper overload. Early diagnosis is complicated by the rarity and diversity of manifestations. Objective To describe the diagnostic features and response to treatment in our cohort of WD patients. Methods This was a retrospective analysis of 262 WD patients stratified by clinical presentation, complementary exams, ATP7B genotyping, and response to treatment. Results Symptoms occurred at an average age of 17.4 (7–49) years, and patients were followed up for an average of 9.6 (0–45) years. Patients presented mainly with hepatic (36.3%), neurologic (34.7%), and neuropsychiatric (8.3%) forms. Other presentations were hematologic, renal, or musculoskeletal, and 16.8% of the patients were asymptomatic. Kayser-Fleischer rings occurred in 78.3% of the patients, hypoceruloplasminemia in 98.3%, and elevated cupruria/24h in 73.0%, with an increase after D-penicillamine in 54.0%. Mutations of the ATP7B gene were detected in 84.4% of alleles. Brain magnetic resonance imaging showed abnormalities in the basal ganglia in 77.7% of patients. D-penicillamine was the first choice in 93.6% of the 245 patients, and 21.1% of these patients were switched due to adverse effects. The second-line therapies were zinc and trientine. The therapeutic response did not differ significantly between the drugs (p= 0.2). Nine patients underwent liver transplantation and 82 died. Conclusion Wilson disease is diagnosed at a late stage, and therapeutic options are limited. In people under 40 years of age with compatible manifestations, WD could be considered earlier in the differential diagnosis. There is a need to include ATP7B genotyping and therapeutic alternatives in clinical practice. (WD overload manifestations 26 presentation exams ATPB ATP B 174 17 4 17. 7–49 749 7 49 (7–49 96 9 6 9. 0–45 045 0 45 (0–45 36.3%, 363 36.3% , 36 3 (36.3%) 34.7%, 347 34.7% 34 (34.7%) 8.3% 83 8 (8.3% forms hematologic renal musculoskeletal 168 16 16.8 asymptomatic KayserFleischer Kayser Fleischer 783 78 78.3 983 98 98.3% cupruria24h cupruriah cupruria 24h h 730 73 73.0% Dpenicillamine D penicillamine 540 54 54.0% 844 84 84.4 alleles 777 77 77.7 936 93 93.6 24 211 21 1 21.1 effects secondline second line trientine p= p (p 0.2. 02 0.2 . 2 0.2) died stage limited practice 7–4 74 (7–4 0–4 04 (0–4 36.3 (36.3% 34.7 (34.7% 8.3 (8.3 16. 78. 98.3 73.0 5 54.0 84. 77. 93. 21. 0. 7– (7– 0– (0– 36. (36.3 34. (34.7 8. (8. 98. 73. 54. (7 (0 (36. (34. (8 ( (36 (34 (3
5.
NPPC and AREG supplementation in IVM systems alter mRNA translation and decay programs-related gene expression in bovine COC programsrelated programs related
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Saraiva, Helena Fabiana Reis de Almeida
; Sangalli, Juliano Rodrigues
; Alves, Luana
; Silveira, Juliano Coelho da
; Meirelles, Flávio Vieira
; Perecin, Felipe
.
Abstract During oocyte meiosis resumption, a coordinated program of transcript translation and decay machinery promotes a remodeling of mRNA stores, which determines the success of the acquisition of competence and early embryo development. We investigated levels of two genes related to mRNA translation (CPEB1 and CPEB4) and two related to mRNA degradation (CNOT7 and ZFP36L2) machinery and found ZFP36L2 downregulated in in vitro-matured bovine oocytes compared to in vivo counterparts. Thereafter, we tested the effects of a pre-IVM step with NPPC and a modified IVM with AREG on the modulation of members of mRNA translation and degradation pathways in cumulus cells and oocytes. Our data showed a massive upregulation of genes associated with translational and decay processes in cumulus cells, promoted by NPPC and AREG supplementation, up to 9h of IVM. The oocytes were less affected by NPPC and AREG, and even though ZFP36L2 transcript and protein levels were downregulated at 9 and 19h of IVM, only one (KDM4C) from the ten target genes evaluated was differently expressed in these treatments. These data suggest that cumulus cells are more prone to respond to NPPC and AREG supplementation in vitro, regarding translational and mRNA decay programs. Given the important nursing role of these cells, further studies could contribute to a better understanding of the impact of these modulators in maternal mRNA modulation and improve IVM outcomes. resumption stores development CPEB1 CPEB (CPEB CPEB4 CNOT7 CNOT (CNOT ZFPL ZFP L ZFP36L vitromatured vitro matured counterparts Thereafter preIVM pre h KDM4C KDMC KDM C (KDM4C treatments programs outcomes
6.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
7.
Women with pelvic organ prolapse and fibulin-5 rs12589592 polymorphism fibulin5 fibulin 5 fibulin- rs rs1258959 rs125895 rs12589 rs1258 rs125 rs12 rs1
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Maeda, Fabiana Garcia Reis
; Palos, Claudia Cristina
; Fernandes, Cesar Eduardo
; Souto, Ricardo Peres do
; Oliveira, Emerson de
.
Revista da Associação Médica Brasileira
- Métricas do periódico
SUMMARY OBJECTIVE: This study aims to access the frequency of single-nucleotide polymorphism rs12589592 (G>A) of the fibulin-5 gene in a Brazilian population with pelvic organ prolapse. METHODS: This was a case-control study, with menopausal women divided into two groups and classified using the pelvic organ prolapse quantification system: pelvic organ prolapse group: pelvic organ prolapse quantification system stages III and IV and Control group: pelvic organ prolapse quantification system stages I and 0. We collected epidemiologic and baseline health information and performed genotyping of rs12589592 from the fibulin-5 gene using a restriction fragment length polymorphism (polymerase chain reaction-restriction fragment length polymorphism) strategy, based on the distinction of sequences from alleles G and A by the restriction enzyme DdeI. For the pelvic organ prolapse group and control, 111 and 180 women were recruited, respectively. RESULTS: The rs12589592 (G>A) polymorphism analysis showed 141 GG homozygotes (pelvic organ prolapse group: 53 [47.7%] and Control: 88 [49.2%] p=0.850); and 149 AA+GA: (pelvic organ prolapse group: 58 [52.3%]; Control: 91 [50.8%]; p=0.904). The distribution of genotypes did not follow the Hardy-Weinberg equilibrium conditions. CONCLUSION: There was no difference between groups regarding genotypes (rs12589592 G>A) frequency; however, the population characteristics prevent the analysis of the association between the genotype and the occurrence of prolapse. OBJECTIVE singlenucleotide single nucleotide rs rs1258959 G>A GA (G>A fibulin5 fibulin 5 fibulin- METHODS casecontrol case control 0 polymerase reactionrestriction reaction strategy DdeI 11 18 recruited respectively RESULTS 14 47.7% 477 47 7 [47.7% 8 49.2% 492 49 2 [49.2% p=0.850 p0850 p 850 p=0.850) AA+GA AAGA AA 52.3% 523 52 3 [52.3%] 9 50.8% 508 50 [50.8%] p=0.904. p0904 p=0.904 . 904 p=0.904) HardyWeinberg Hardy Weinberg conditions CONCLUSION (rs1258959 however rs125895 1 47.7 4 [47.7 49.2 [49.2 p=0.85 p085 85 52.3 [52.3% 50.8 [50.8% p090 p=0.90 90 (rs125895 rs12589 47. [47. 49. [49. p=0.8 p08 52. [52.3 50. [50.8 p09 p=0.9 (rs12589 rs1258 [47 [49 p=0. p0 [52. [50. (rs1258 rs125 [4 p=0 [52 [50 (rs125 rs12 [ p= [5 (rs12 rs1 (rs1 (rs
8.
Comparison of energy expenditure between women with anorexia nervosa in outpatient treatment and healthy controls
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Reis, Tâmara Oliveira dos
; Kattah, Fabiana Martins
; Soares, Maria Marta Sarquis
; Torres, Henrique Oswaldo da Gama
.
RESUMO Objetivo A taxa metabólica de repouso é uma informação importante para o monitoramento nutricional na anorexia nervosa e buscou-se investigar diferenças nas medidas da taxa metabólica de repouso por diferentes métodos entre pacientes de anorexia nervosa com baixo peso e recuperados e controles saudáveis. Métodos Os participantes foram distribuídos em grupos de anorexia nervosa ativa, anorexia nervosa recuperada e indivíduos saudáveis. A calorimetria indireta, medida padrão ouro da taxa metabólica de repouso, foi utilizada para comparar o desempenho das equações de Harris e Benedict, Shebendach, FAO/OMS e Buchholz. O índice de massa corporal e a massa livre de gordura também foram medidos. Foram comparadas médias e medianas dos métodos de avaliação da taxa metabólica de repouso e também foi empregado análise de Bland Altman e tabelas de diferenças percentuais para comparar os diferentes métodos. Resultados No grupo de anorexia nervosa ativa as equações de Buchholz, Harris e Benedict e FAO/WHO superestimaram a taxa metabólica de repouso, o que não foi observado com a equação de Schebendach. No grupo de anorexia nervosa recuperada, a equação de Schebendach subestimou a taxa metabólica de repouso, enquanto as outras equações, com exceção da FAO/OMS, não o fizeram. A análise de Bland Altman sugeriu a adequação da equação de Shedenbach na anorexia nervosa ativa. Na anorexia nervosa recuperada, os vieses proporcionais observados para as equações de Harris e Benedict, Buchholz e FAO/OMS indicaram sua inadequação para este grupo. Conclusão Em pacientes com anorexia ativa, os resultados indicam que a equação de Schebendach pode ser adequada para estimar a taxa metabólica de repouso. Nenhuma das equações mostrou adequação para estimar a taxa metabólica de repouso em pacientes recuperados. buscouse buscou se saudáveis indireta Shebendach FAOOMS FAO OMS medidos FAOWHO WHO fizeram
ABSTRACT Objective Resting metabolic rate is an important measure for nutritional monitoring in anorexia nervosa. This study aims to investigate the differences in resting metabolic rate measurements across various methods between underweight and recovered anorexia nervosa patients, as well as healthy controls. Methods Participants were categorized into three groups: active anorexia nervosa, recovered anorexia nervosa, and healthy individuals. Indirect calorimetry, the gold standard for resting metabolic rate measurement, was used to evaluate the performance of the Harris-Benedict, Schebendach, FAO/WHO, and Buchholz equations. Body mass index and fat free mass were also measured. Mean and median resting metabolic rate values across evaluation methods were compared, and Bland-Altman plots along with percent difference tables were employed to compare the different methods. Results In the active anorexia nervosa group, the Buchholz, Harris-Benedict, and FAO/WHO equations overestimated resting metabolic rate, whereas the Schebendach equation did not. In the recovered anorexia nervosa group, Schebendach’s equation underestimated resting metabolic rate, while the other equations, with the exception of FAO/WHO, did not. Bland-Altman analysis supported the adequacy of the Schebendach equation in active anorexia nervosa. In recovered anorexia nervosa, proportional biases observed for the Harris-Benedict, Buchholz, and FAO/WHO equations indicated its inadequacies for this group. Conclusion In patients with active anorexia nervosa, the results indicate that the Schebendach equation may be adequate for estimating resting metabolic rate. However, none of the equations showed adequacy for estimating resting metabolic rate in recovered patients. controls groups individuals calorimetry measurement HarrisBenedict, HarrisBenedict Harris Benedict, Benedict Harris-Benedict FAOWHO FAO WHO measured compared BlandAltman Bland Altman group not Schebendachs s However
9.
Influence of the calving season of Girolando calves on development in the initial phase after birth, reproductive performance, and productive performance birth
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Resumo A criação de bezerras é uma das atividades mais importantes na bovinocultura leiteira, visto que estas serão os animais de reposição do rebanho. Objetivou-se avaliar o efeito da estação de nascimento da bezerra no desenvolvimento na fase de cria e desempenho reprodutivo e produtivo. O experimento foi conduzido na Fazenda Experimental Glória, da Universidade Federal de Uberlândia. Foram avaliadas 74 bezerras nascidas de janeiro/2018 a março/2020, desde o primeiro dia de vida ao final da sua primeira lactação. Os animais foram categorizados de acordo com a estação de nascimento: primavera/verão (outubro a março) e outono/inverno (abril a setembro). Durante o aleitamento foi avaliado o peso dos animais nos dias: 0, 30, 60 após o nascimento e no desaleitamento. A temperatura retal, o escore de fezes, a ingestão de alimento e o comportamento animal foram monitorados diariamente. Na vida adulta foram avaliadas data da cobertura fértil, do parto e monitorada a produção de leite durante a primeira lactação. As variáveis analisadas foram: ganho de peso durante o aleitamento, ocorrência de doenças na fase de aleitamento, porcentagem de novilhas que pariram, idade ao primeiro parto e média de produção de leite da primeira lactação de acordo com a estação de nascimento. As variáveis contínuas foram analisadas por análise de variância e as variáveis binomiais por regressão logística no programa MINITAB. As bezerras nascidas na estação outono/inverno apresentam maior peso aos 30 dias, porém esta diferença foi compensada durante o aleitamento, não interferindo no desempenho reprodutivo e produtivo. leiteira rebanho Objetivouse Objetivou se produtivo Glória Uberlândia 7 janeiro2018 janeiro 2018 janeiro/201 março2020 março 2020 março/2020 primaveraverão primavera verão outubro outonoinverno outono inverno abril setembro. setembro . setembro) dias 0 6 desaleitamento retal fezes diariamente fértil pariram MINITAB 3 janeiro201 201 janeiro/20 março202 202 março/202 janeiro20 20 janeiro/2 março20 março/20 janeiro2 2 janeiro/ março2 março/2 março/
Abstract Raising heifers is one of the most important activities in dairy farming because heifers eventually replace the herd. This study was performed to evaluate how the calf’s birth season affects its early development and its reproductive and productive performance. The experiment was conducted at the Glória Experimental Farm of the Federal University of Uberlândia, Minas Gerais, Brazil. In total, 74 female calves born from January 2018 to March 2020 were evaluated from the first day of life to the end of their first lactation. The animals were classified according to their season of birth: spring/summer (October–March) or fall/winter (April–September). During the initial phase of life, the animals’ weights were assessed on days 0, 30, and 60 after birth and at weaning. The rectal temperature, fecal score, feed intake, and animal behavior were recorded daily. In the mature phase of life, the dates of conception and calving were evaluated, and milk production during the first lactation was monitored. The following variables were analyzed according to season of birth: weight gain and occurrence of diseases during the initial phase, percentage of heifers that calved, age at first calving, and average milk production during the first lactation. Continuous variables were analyzed by analysis of variance, and binomial variables were analyzed by logistic regression using the Minitab software program. Calves born in fall/winter had a higher weight at 30 days; however, this difference was compensated for during the initial phase and did not interfere with reproductive and productive performance. herd calfs calf s performance Uberlândia Gerais Brazil total 7 201 202 springsummer spring summer October–March OctoberMarch October (October–March fallwinter fall winter April–September. AprilSeptember April–September . April September (April–September) 0 6 weaning temperature score intake daily monitored calved variance program 3 however 20 (April–September 2
10.
Brazilian dental consensus on dental management in hematopoietic stem cell transplantation−Part I−pre-HSCT transplantationPart transplantation Part I−preHSCT IpreHSCT I−pre HSCT I pre preHSCT Ipre
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Correa, Maria Elvira Pizzigati
; Granzotto, Fabiana Caramori Noal
; Innocentini, Lara Maria Alencar Ramos
; Reis, Thiago de Carvalho
; Lima, Emilze Mafra de
; Varanda, Renata de Freitas
; Santos, Paulo Sérgio da Silva
; Soares Junior, Luiz Alberto Valente
; Bezinelli, Leticia Mello
; Eduardo, Fernanda de Paula
; Melo, Walmyr Ribeiro
; Antunes, Héliton Spíndola
; Macedo, Leandro Dorigan De
.
Hematology, Transfusion and Cell Therapy
- Métricas do periódico
ABSTRACT The oral involvement in the Hematopoietic Stem Cell Transplantation is well described in the literature. The goal of the dental treatment and management of the oral lesions related to the HSCT is to reduce the harm caused by preexisting oral infection or even the worsening of oral acute/chronic GVHD and late effects. The aim of this guideline was to discuss the dental management of patients subjected to HSCT, considering three phases of the HSCT: pre-HSCT, acute phase, and late phase. The literature published from 2010 to 2020 was reviewed in order to identify dental interventions in this patient population. The selected papers were divided into three groups: pre-HSCT, acute and late, and were reviewed by the SBTMO Dental Committee's members. When necessary, an expertise opinion was considered for better translating the guideline recommendations to our population dental characteristics. This manuscript focused on the pre-HSCT dental management. The objective of the pre-HSCT dental management is to identify possible dental situations that On behalf of the Dental Committee of the Brazilian Society of Gene Therapy and Bone Marrow Transplantation (SBTMO) can worsening during the acute phase after the HSCT. Each guideline recommendations were made considering the Dentistry Specialties. The clinical consensus on dental management prior to HSCT provides professional health caregivers with clinical setting-specific information to help with the management of dental problems in patients to be subjected to HSCT. acutechronic chronic effects preHSCT, preHSCT pre 201 202 groups Committees s members necessary characteristics (SBTMO Specialties settingspecific setting specific 20 2
11.
Longitudinal analyses of composite resin restoration on erosive lesions: effect of dentin treatment with a chitosan nanoformulation containing green tea
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Reis, Renato Gonçalves dos
; Tedesco, Antônio Cláudio
; Curylofo-Zotti, Fabiana Almeida
; Cortez, Thiago Vinicius
; Borges, Hiago Salge
; Souza-Gabriel, Aline Evangelista
; Corona, Silmara Aparecida Milori
.
Aim To evaluate the influence of the biomodification of erosive lesions with a chitosan nanoformulation containing green tea (NanoCsQ) on the clinical performance of a composite resin. Methods The study was performed in a split-mouth, randomized and double-blinded model with 20 patients with 40 erosive lesions. The patient’s teeth were randomized into two groups (n=20) according to the surface treatment: 1) Without biomodification (control), and 2) Biomodification with NanoCsQ solution (experimental). The lesions were restored with adhesive (Tetric N-bond, Ivoclar) and composite resin (IPS Empress Direct, Ivoclar). The restorations were polished and 7 days (baseline), 6 months, and 12 months later were evaluated according to the United States Public Health Service (USPHS) modified criteria, using clinical exam and photographics. Data were analyzed by Friedman’s and Wilcoxon signed-rank tests. Results No significant differences were found between the control and experimental groups (p=0.423), and also among the follow-up periods (baseline, six months, and 12 months) (p=0.50). Regarding the retention criteria, 90% of the restoration had an alpha score in the control group. Only 10% of the restorations without biomodification (control) had a score charlie at the 12-month follow-up. None of the patients reported post-operatory sensitivity. Conclusion The NanoCsQ solution did not negatively affect the performance of the composite resin restorations after 12 months.
12.
Microbial diversity of Syrah grapes cultivated for winter wine production in Minas Gerais, Brazil Gerais
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Lira, Nathasha de Azevedo
; Goulart, Nádjla Miranda Vilela
; Passamani, Fabiana Reinis Franca
; Evangelista, Suzana Reis
; Santos, Miriam Aparecida de Aguilar
; Batista, Luis Roberto
.
RESUMO Os microrganismos desempenham um papel fundamental na determinação do terroir da região onde os vinhedos são cultivados, influenciando as características do vinho produzido nessa região. Nesse sentido, este estudo teve como o objetivo determinar a micobiota terroir de uvas variedade Syrah de vinhedos sub-tropicais localizados no sul de Minas Gerais. O material genético foi extraído para a obtenção do DNA total e seu sequenciamento foi realizado pelo programa Illumina, usando a região ITS rRNA. Perfis taxonômicos foram obtidos em Domínio, Filo, Classe, Ordem, Família, Gênero e Espécie, observando-se que houve uma maior predominância do filo Ascomycota, seguido de Basidiomycota. Também foi construída uma árvore filogenética com as 20 principais espécies de fungos presente nas uvas, respresentadas pelos gêneros Cercospora, Uwebraunia, Aureobasidium, Leptospora, Pseudopithomyces, Periconia, Acrocalyma, Alternaria, Aspergillus, Pecinicillium, Hansfordia, Meyerozyma, Candida, Wickerhamomyces, Acremonium, Sarocladium, Giberella e Colletotrichum. A caracterização da diversidade microbiana das uvas foi obtida com sucesso, no entanto, pôde-se observar um grande número de indivíduos que não foram classificados, levando a crer que estudos futuros nessa área precisam ter continuidade para que, cada vez mais, possamos ter conhecimento dessas espécies e entender como funcionam esses sistemas. cultivados sentido subtropicais sub tropicais Gerais Illumina rRNA Domínio Filo Classe Ordem Família Espécie observandose observando se Ascomycota Basidiomycota 2 Cercospora Uwebraunia Aureobasidium Leptospora Pseudopithomyces Periconia Acrocalyma Alternaria Aspergillus Pecinicillium Hansfordia Meyerozyma Candida Wickerhamomyces Acremonium Sarocladium Colletotrichum sucesso entanto pôdese pôde classificados mais sistemas
ABSTRACT Microorganisms play a key role in determining the terroir of any region where vineyards are cultivated, influencing the characteristics of the wine produced in that region. This study aimed to determine the mycobiota terroir of Syrah grapes from subtropical vineyards of southern Minas Gerais, Brazil, using independent cultivation methods. Total DNA was extracted from the grapes and internal transcribed spacer/rRNA regions were sequenced. Taxonomic profiles were obtained at the kingdom, phylum, class, order, family, genus, and species levels. The results showed a predominance of the phylum Ascomycota, followed by Basidiomycota. A phylogenetic tree was also constructed with the top 20 species of fungi present in the grapes, mainly represented by the genera Cercospora, Uwebraunia, Aureobasidium, Leptospora, Pseudopithomyces, Periconia, Acrocalymma, Alternaria, Aspergillus, Penicillium, Hansfordia, Meyerozyma, Candida, Wickerhamomyces, Acremonium, Sarocladium, Gibberella, and Colletotrichum. The fungal diversity of the grapes was successfully characterized, but many individuals were not classified, indicating that future studies should be performed to better understand the profile of the species found, as well as their functions in this system. cultivated Gerais Brazil methods spacerrRNA spacer rRNA sequenced kingdom class order family genus levels Ascomycota Basidiomycota 2 Cercospora Uwebraunia Aureobasidium Leptospora Pseudopithomyces Periconia Acrocalymma Alternaria Aspergillus Penicillium Hansfordia Meyerozyma Candida Wickerhamomyces Acremonium Sarocladium Gibberella Colletotrichum characterized classified found system
13.
Consensus for teaching dental caries in the Portuguese Language at Brazilian dental schools
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SAMPAIO, Fabio Correia
; BÖNECKER, Marcelo
; PAIVA, Saul Martins
; ARTHUR, Rodrigo Alex
; COHEN-CARNEIRO, Flavia
; DITTERICH, Rafael
; PIRES, Fabiana Schneider
; WANG, Linda
; CAVALCANTE, Larissa Maria
; GATTI-REIS, Luisa
; SPÍNOLA, Vitoria Borges
; MARTIGNON, Stefania
; MALHEIROS, Zilson
; STEWART, Bernal
; CARCERERI, Daniela Lemos
; SCAVUZZI, Ana Isabel
; FONTANELLA, Vania
.
Abstract The aim of this paper was to present a summary of the process of developing and preparing the final documents of the national consensus for teaching undergraduate Brazilian dental students the dental caries curriculum in the Portuguese language. The final document was developed in three steps: a) The ABENO and LAOHA cariology group invited experts from all five regions of Brazil to participate in the discussion. The theoretical support for crafting the first draft of the consensus was based on two publications: National Curriculum Guidelines of the Dentistry graduation in Brazil, Ministry of Education (2021) and the competences described in the European Core Curriculum for Cariology (ORCA-ADEE, 2011); b) The group of experts was divided into 5 working groups: G1-Domain, Main and Specific Competences, G2-Essential knowledge, G3-Life course perspective, G4-Social determinants and dental caries, G5- Glossary. The document was finalized by thoroughly reviewing the process using Delphi methodology; c) The 5-chapter document (one from each working group) was submitted to three open public consultations in 2022 (May-June, August, and October) using Google-forms. The suggestions (content/wording) were discussed within the group as: totally accepted, partially accepted, and rejected. A total of 192 suggestions were registered from 31 dental schools in all regions of Brazil. The number of suggestions received per Group were: 84, 28, 26, 24, 30 suggestions for G1, G2, G3, G4 and G5, respectively. The majority of suggestions were totally accepted by the group of experts (n = 172, 89.6%), 15 were partially accepted (7.8%), and 5 were rejected. Conclusion The final document could be considered to be the first national consensus for teaching the dental caries curriculum in Brazil. language steps discussion publications 2021 (2021 ORCAADEE, ORCAADEE ORCA ADEE, ADEE (ORCA-ADEE 2011 2011) b groups G1Domain, G1Domain GDomain G1 Domain, Domain G G1-Domain Competences G2Essential GEssential G2 Essential knowledge G3Life GLife G3 Life perspective G4Social GSocial Social G5 Glossary methodology c 5chapter chapter one 202 MayJune, MayJune May June, June (May-June August October Googleforms. Googleforms Google forms. forms Google-forms content/wording contentwording content wording (content/wording as rejected 19 3 84 28 26 24 respectively n 172 89.6%, 896 89.6% , 89 6 89.6%) 1 7.8%, 78 7.8% 7 8 (7.8%) (202 201 20 2 17 89.6 7.8 (7.8% (20 89. 7. (7.8 (2 (7. ( (7
14.
Thermal and Acoustic Properties of Rubberized Mortars for Coatings
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Oliveira, Adriana Gomes de
; Silva, Fabiana Maria da
; Angelin, Andressa Fernanda
; Silva, Marília Reis Nunes da
; Lintz, Rosa Cristina Cecche
; Baldan, Victor José dos Santos
; Gachet, Luísa Andréia
.
Recycled crumb rubber can be sustainable used in mortar both to mitigate nature aggregate consumption, reducing environmental pollution, as well, to improve the acoustic and thermal performance of buildings, without damaging its mechanical properties. This paper explores workability, microstructure, mechanical, thermal and acoustic properties considering increasing contents of crumb rubber (0%, 5%, 10%, 15% and 20% replacement, by volume, of fine aggregate). Mortar characterization tests were carried out in the fresh and hardened state. It has been found that replacing the aggregate with scrap tyre rubber reduced the compressive strength on average 12% and 67% and for tensile strength 35% and 53%, for the contents of 10% and 20% respectively, compared to the reference. Furthermore, it was found that the reductions in thermal conductivity reached 16% and 29% and an increase in acoustic attenuation on average 12% and 13%. Moreover, scanning electron microscopy images were analyzed, justifying the mechanical results obtained. Although the experimental results indicated that the workability and mechanical strengths decreased with the increase of rubber replacement rate, the studied mixtures met the standard specifications, and thus suitable for walls and ceilings coating applications, improve the acoustic and thermal performance of buildings and as a sustainable material. consumption pollution well microstructure 0%, 0 (0% 5 5% 10 15 20 volume aggregate. . aggregate) state 12 67 35 53 53% respectively reference Furthermore 16 29 13 13% Moreover analyzed obtained rate specifications applications material 0% (0 1 2 6 3 (
15.
Comparison of McMaster and Mini-FLOTAC techniques for the diagnosis of internal parasites in pigs MiniFLOTAC Mini FLOTAC
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Class, Camila Souza Carvalho
; Fialho, Priscila Alves
; Alves, Leucio Câmara
; Silveira, Renato Luiz
; Amendoeira, Maria Regina Reis
; Knackfuss, Fabiana Batalha
; Barbosa, Alynne da Silva
.
Revista Brasileira de Parasitologia Veterinária
- Métricas do periódico
Resumo Este estudo objetivou comparar a eficiência das técnicas quantitativas de McMaster e Mini-FLOTAC para a pesquisa de helmintos em fezes de suínos. Foram analisadas 74 amostras fecais de suínos mantidos em propriedades familiares, localizadas no Rio de Janeiro, Brasil. Estas foram analisadas pelas técnicas de Mini-FLOTAC e McMaster com solução de NaCl 1.200g/mL. Pode-se verificar uma superioridade na frequência de todos os helmintos detectados por meio do Mini-FLOTAC, incluindo-se Ascaris suum, Trichuris suis, estrongilídeos e Strongyloides ransomi. O índice Kappa mostrou uma concordância substancial em todas as comparações realizadas, em relação à frequência de amostras positivas. Entretanto, diferenças estatísticas significativas na comparação do OPG entre McMaster e Mini-FLOTAC foram observadas para todos os nematoides (p ≤0.05). Elevados valores do coeficiente de correlação de Pearson foram observados entre as técnicas, em relação ao OPG para A. suum e T. suis, diferentemente do evidenciado para estrôngilos e S. ransomi. Mini-FLOTAC mostrou-se uma técnica mais satisfatória e confiável, tanto para o diagnóstico de parasitos quanto para a determinação do OPG em fezes de suínos, devido ao maior tamanho das suas câmaras de contagem, situação que acaba aumentando a eficiência da recuperação dos ovos dos helmintos. MiniFLOTAC Mini FLOTAC 7 familiares Janeiro Brasil 1200gmL gmL 1 200g mL g 1.200g/mL Podese Pode se MiniFLOTAC, FLOTAC, incluindose incluindo suis ransomi realizadas positivas Entretanto p ≤0.05. 005 ≤0.05 . 0 05 ≤0.05) A T S mostrouse confiável contagem 00 ≤0.0 ≤0. ≤0 ≤
Abstract This purpose of this study was to compare the efficiency of the McMaster and Mini-FLOTAC quantitative techniques in the investigation of helminths in feces of pigs. An analysis was made of 74 fecal samples from pigs raised on family farms located in Rio de Janeiro, Brazil. These were analyzed by the Mini-FLOTAC and McMaster techniques in a solution of 1,200g/mL NaCl. This investigation revealed a superiority in the frequency of all helminths detected by Mini-FLOTAC, including Ascaris suum, Trichuris suis, strongyles and Strongyloides ransomi. The Kappa index revealed substantial agreement in all comparisons made in relation to the frequency of positive samples. However, significant statistical differences in the comparison of EPGs between McMaster and Mini-FLOTAC were observed for all nematodes (p ≤0.05). Higher values of Pearson’s linear correlation coefficient (r), between the techniques in relation to EPG were observed for A. suum and T. suis, differently from what was observed for strongyles and S. ransomi. Mini-FLOTAC proved to be a more satisfactory and reliable technique both for the diagnosis of parasites and for the determination of EPG in pig feces due to the larger size of its counting chambers, thus increasing the helminth egg recovery rates. MiniFLOTAC Mini FLOTAC 7 Janeiro Brazil 1200gmL gmL 1 200g mL g NaCl MiniFLOTAC, FLOTAC, suis ransomi However p ≤0.05. 005 ≤0.05 . 0 05 ≤0.05) Pearsons Pearson s r, r , (r) A T S chambers rates 00 ≤0.0 (r ≤0. ≤0 ≤
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