Resumo Fundamento: O Brasil é um país com diferentes biomas e desigualdades sociais. Existem poucos dados disponíveis sobre as diferenças regionais e o prognóstico da insuficiência cardíaca (IC) no país. Objetivo: O estudo Rosa dos Ventos tem como objetivo investigar as diferenças regionais e o prognóstico atual de pacientes com IC com fração de ejeção reduzida ou moderadamente reduzida no Brasil. Métodos: Este é um estudo prospectivo, multicêntrico, observacional, do tipo coorte que incluirá pacientes ambulatoriais com idade superior a 18 anos com IC e fração de ejeção < 50% em 30 centros privados distribuídos nas regiões brasileiras. Um total de 2500 pacientes serão incluídos entre junho de 2021 e outubro de 2023, com um período de 12 meses de seguimento. Coletaremos dados sobre status clínico e socioeconômico, prescrição médica e resultados de exames cardiológicos. Serão realizados telefonemas para o seguimento dos pacientes seis e 12 meses após a inclusão para coleta de informações sobre visitas ao departamento de emergência, internações e mortalidade. Conclusão: O estudo Rosa dos Ventos permitirá uma caracterização mais precisa da IC crônica no Brasil. Essa iniciativa proverá informações relevantes para o desenvolvimento de estratégias de manejo efetivas para mitigar o impacto dessa condição sobre os pacientes e o sistema de saúde. Fundamento sociais (IC Objetivo Métodos prospectivo multicêntrico observacional 1 50 3 brasileiras 250 202 2023 socioeconômico cardiológicos emergência mortalidade Conclusão saúde 5 25 20 2

Abstract Background: Brazil is a country with different biomes and social disparities. There are limited data available on regional differences and prognosis of heart failure (HF) in the country. Objective: The Rosa dos Ventos study aims to investigate regional differences and the current prognosis of HF outpatients with reduced or mildly reduced ejection fraction in Brazil. Methods: This is a prospective, multicenter, observational cohort study that will include outpatients older than 18 years with HF and an ejection fraction < 50% in 30 public and private centers distributed in all Brazilian regions. A total of 2,500 patients will be enrolled from June 2021 and October 2023, with a 12-month follow-up period. We will collect data on socioeconomic and clinical status, medical prescription and results of cardiology tests. Follow-up phone calls will be made at 6 and 12 months after inclusion to collect information regarding emergency room visits, hospitalization and mortality. Conclusion: The Rosa dos Ventos study will allow a more accurate characterization of chronic HF in Brazil. This initiative will provide relevant information for the development of effective management strategies to mitigate the impact of this condition on patients and the healthcare system. Background disparities (HF Objective Methods prospective multicenter 1 50 3 regions 2500 2 500 2,50 202 2023 12month month followup follow up period status tests Followup Follow visits mortality Conclusion system 5 250 2,5 20 25 2,

ABSTRACT Purpose: To analyze the potential of tumor necrosis factor-α (TNF-α) and factor nuclear kappa B (NF-κB) as colorectal cancer (CRC) biomarkers in an experimental model of intestinal carcinogenesis with 1,2-dimethyhydrazine (1,2-DMH). Methods: Twenty-four male Wistar rats were divided into two groups: sham and 1,2-DMH. First, 1,2-DMH (20 mg/kg/week) was administered for 15 consecutive weeks. In the 25th week, proctocolectomy was conducted. Histopathological analysis, immunohistochemistry, and gene expression of TNF-α and NF-κB were performed. Statistical analysis was performed using GraphPad Prism. The location of aberrant crypt foci (ACF) was analyzed by Kruskal-Wallis’ test. For analyses with two groups with parametric data, the t-test was used; for non-parametric data, the Mann-Whitney’s test was used. P < 0.05 was considered significant. Results: The number of ACF and macroscopic lesions was significantly higher (p < 0.5) in the 1,2-DMH group compared to the sham group, and most ACF were concentrated in the distal segment of the colon. There was a statistically significant increase (p < 0.5) in protein and gene expression of TNF-α and NF-κB in the 1,2-DMH group compared to the sham group. Conclusions: Our results provide supportive evidence that TNF-α and NF-κB pathways are strongly involved in CRC development in rats and might be used as early biomarkers of CRC pathogenesis in experimental studies. Purpose factorα α TNFα TNF (TNF-α NFκB NF κB (NF-κB (CRC 1,2dimethyhydrazine 12dimethyhydrazine dimethyhydrazine 1,2 1 2 1,2DMH. 12DMH DMH . (1,2-DMH) Methods Twentyfour Twenty four DMH. First 1,2DMH 20 (2 mg/kg/week mgkgweek mg kg week weeks th conducted immunohistochemistry Prism (ACF KruskalWallis Kruskal Wallis Kruskal-Wallis data ttest t nonparametric non MannWhitneys Mann Whitney s 005 0 05 0.0 Results p 0.5 5 colon Conclusions studies 2dimethyhydrazine 12 1, 2DMH (1,2-DMH ( 00 0.

Resumo O objetivo deste estudo foi analisar a distribuição das variáveis antropométricas de acordo com características demográficas, socioeconômicas e de saúde em crianças, de zero a cinco anos, de descendência haitiana residentes em Cuiabá-MT, Brasil. Consiste em estudo transversal, com dados coletados entre agosto/2016 e fevereiro/2017. As variáveis dependentes foram o índice de massa corporal (IMC) e a estatura/idade em escore-z, sendo utilizado o Teste t de Student e ANOVA na análise estatística. Foram avaliadas 67 crianças, 73,2% com até 24 meses de idade e 34,3% do sexo masculino. Observou-se expressiva proporção de famílias com renda per capita inferior a 1/4 de salário mínimo (65,6%), sem acompanhamento domiciliar pela Estratégia Saúde da Família (88,1%) e elevada carga horária de trabalho das mães (43,3%). O início do pré-natal até o terceiro mês de gestação e sexo feminino foram associados a maiores médias de IMC. Quanto a estatura/idade, foi identificada associação com menores médias para domicílios com mais de um morador por cômodo, faixa etária mais elevada da criança e cuidado da criança em creches. Apesar de poucos fatores apresentaram associação com os indicadores antropométricos avaliados, é necessário atentar-se para as condições socioeconômicas precárias nas quais estas crianças estão inseridas.

Abstract The scope of this study was to analyze the distribution of anthropometric variables according to demographic, socioeconomic, and health characteristics among children of Haitian descent between 0 and 5 years of age living in Cuiabá-MT. It consists of a cross-sectional and census-based study with data collected between August 2016 and February 2017. The dependent variables were body mass index (BMI) and height-for-age z-score, using Student’s t-Test and ANOVA in the statistical analysis. A total of 67 children, 73.2% to 24 months of age and 34.3% being male, were evaluated. There was a significant proportion of families with per capita income of less than 1/4 of the minimum wage (65.6%), with no home monitoring for the family health strategy (88.1%), and long working hours for mothers (43.3%). The onset of prenatal care until the third month of pregnancy and female sex were associated with higher BMI averages. For height-for-age, an association with lower mean values was found for households with more than one resident per room, higher age range of the child, and child-care in daycare centers. Thus, although few factors have an association with the anthropometric indications evaluated, it is necessary to consider the precarious socioeconomic conditions in which these children find themselves.

Resumo O objetivo deste estudo foi analisar a distribuição das variáveis antropométricas de acordo com características demográficas, socioeconômicas e de saúde em crianças, de zero a cinco anos, de descendência haitiana residentes em Cuiabá-MT, Brasil. Consiste em estudo transversal, com dados coletados entre agosto/2016 e fevereiro/2017. As variáveis dependentes foram o índice de massa corporal (IMC) e a estatura/idade em escore-z, sendo utilizado o Teste t de Student e ANOVA na análise estatística. Foram avaliadas 67 crianças, 73,2% com até 24 meses de idade e 34,3% do sexo masculino. Observou-se expressiva proporção de famílias com renda per capita inferior a 1/4 de salário mínimo (65,6%), sem acompanhamento domiciliar pela Estratégia Saúde da Família (88,1%) e elevada carga horária de trabalho das mães (43,3%). O início do pré-natal até o terceiro mês de gestação e sexo feminino foram associados a maiores médias de IMC. Quanto a estatura/idade, foi identificada associação com menores médias para domicílios com mais de um morador por cômodo, faixa etária mais elevada da criança e cuidado da criança em creches. Apesar de poucos fatores apresentaram associação com os indicadores antropométricos avaliados, é necessário atentar-se para as condições socioeconômicas precárias nas quais estas crianças estão inseridas.

Abstract The scope of this study was to analyze the distribution of anthropometric variables according to demographic, socioeconomic, and health characteristics among children of Haitian descent between 0 and 5 years of age living in Cuiabá-MT. It consists of a cross-sectional and census-based study with data collected between August 2016 and February 2017. The dependent variables were body mass index (BMI) and height-for-age z-score, using Student’s t-Test and ANOVA in the statistical analysis. A total of 67 children, 73.2% to 24 months of age and 34.3% being male, were evaluated. There was a significant proportion of families with per capita income of less than 1/4 of the minimum wage (65.6%), with no home monitoring for the family health strategy (88.1%), and long working hours for mothers (43.3%). The onset of prenatal care until the third month of pregnancy and female sex were associated with higher BMI averages. For height-for-age, an association with lower mean values was found for households with more than one resident per room, higher age range of the child, and child-care in daycare centers. Thus, although few factors have an association with the anthropometric indications evaluated, it is necessary to consider the precarious socioeconomic conditions in which these children find themselves.

Neste trabalho avaliou-se o levantamento fitossociológico e determinaram-se os períodos críticos de competição com a cultura da mandioca, submetida ou não à adubação NPK. Para tanto, as plantas infestantes foram colhidas a cada 35 dias, até os 525 dias após a plantação da mandioca, por meio do lançamento aleatório de um quadrado de ferro vazado de 0,5 x 0,5 m (0,25 m²) na área útil das parcelas com e sem adubação. As plantas no interior do quadrado foram cortadas rente ao solo, contadas e identificadas por espécie. Sida rhombifolia, Brachiaria plantaginea e Cynodon dactylon apresentaram os maiores índices de frequência relativa (FR), densidade relativa (DR), abundância relativa (AR) e índice de valor de importância (IVI). Posteriormente, os dados de produtividade de raízes tuberosas foram ajustados ao modelo de regressão não linear sigmoidal de Boltzmann, para determinação dos períodos críticos de competição: período anterior à interferência (PAI), período total de prevenção à interferência PTPI e período crítico de prevenção à interferência (PCPI). A adubação fornecida à cultura da mandioca influenciou a determinação de diferentes índices fitossociológicos e períodos críticos de competição.

The objective of this study was to evaluate the phytosociological survey and determine the critical periods of weeds competition with the cassava crop, submitted or not to NPK fertilization. Therefore, the weeds were collected every 35 days, until 525 days after cassava planting, through the random release of a cast iron square 0.5 m x 0.5 m (0.25 m²) in plots with and without fertilization. The plants inside the square were cut close to the ground, counted and identified by species. Sida rhombifolia, Brachiaria plantaginea and Cynodon dactylon showed the highest FR, DR, AR and IVI. Subsequently, the yield data of storage roots were adjusted to non-linear regression model sigmoidal Boltzmann to determine the critical periods of competition: PAI, TPIC and PCPI. The fertilizer supplied to cassava crop contributed to the determination of different phytosociological indices and critical periods of competition.

Resumo Objetivos: analisar o acompanhamento pré-natal realizado pelas gestantes haitianas e brasileiras residentes no estado de Mato Grosso. Métodos: estudo transversal de base secundária, com análise de registros de nascimento do SINASC em Mato Grosso entre 2013 e 2015, de crianças brasileiras, filhos de mães brasileiras e de mães de nacionalidade haitiana. Foram avaliadas variáveis relativas à identificação do recém-nascido e da mulher, dados maternos sobre histórico gestacional, incluindo informações sobre o acompanhamento pré-natal da última gestação, além das características do parto. Resultados: foram registrados 167.820 nascidos vivos no estado no período avaliado, sendo 139 (0,08%) filhos de mulheres haitianas. As mães haitianas apresentaram faixa etária mais elevada, contudo, com menor escolaridade quando comparadas as mães brasileiras. Foi menor a proporção de mães de nacionalidade haitianas que tiveram pelo menos 6 consultas pré-natais e maior a proporção de partos vaginais, quando comparadas às brasileiras. Também foi maior a prevalência de baixo peso ao nascer entre os nascidos vivos de mães haitianas. Conclusões: os resultados deste estudo apontam para a necessidade de compreensão destas diferenças, pois alguns indicadores distanciaram-se do preconizado pela OMS. Esses achados podem contribuir para o desenvolvimento de políticas públicas voltadas para esta população.

Abstract Objectives: to analyze the prenatal follow-up performed by pregnant women in Haiti and Brazil in the state of Mato Grosso. Methods: a cross-sectional study of secondary database, with analysis of SINASC birth records in Mato Grosso between 2013 and 2015, of Brazilian children, born from both Brazilian and Haitian mothers. Variables related to the identification of the newborn and the woman, maternal data on gestational history, including information on prenatal follow-up of the last gestation were evaluated, besides the birth characteristics. Results: 167,820 live births were registered in the state in the period, of which 139 (0.08%) were children of Haitian women. Haitian mothers were older, however with lower schooling when compared to Brazilian mothers. The proportion of mothers of Haitian nationality who had at least 6 prenatal consultations was lower, and the proportion of vaginal births was higher, when compared to Brazilian women. The prevalence of low birth weight among live births of Haitian mothers was also higher. Conclusions: the results of this study point to the need to understand these differences, since some indicators have distanced from those advocated by WHO. These findings may contribute to the public policies development aimed at this population.

Abstract: The aim of this study was to translate and cross-culturally adapt the condition-specific instrument Impact of Fixed Appliances Measure (IFAM), assessing its validity and reliability for use among Brazilian children/adolescents. The IFAM was translated, back-translated, cross-culturally adapted, and pilot-tested. The Brazilian version of the IFAM (B-IFAM) was tested on 161 10-to-18-year-old children/adolescents. Internal consistency was assessed using Cronbach's alpha (α) and test-retest reliability by intraclass correlation coefficients (ICC). Construct validity was conducted using Pearson correlation among the overall and subscales of the B-IFAM. Discriminant validity was evaluated by comparisons of B-IFAM's means and SD with children's/adolescents' sex (Student t-test). Internal consistency was 0.89 for overall score and 0.55–0.86 for subscales. ICC for test-retest reliability was 0.81 for overall score and 0.55–0.78 for subscales. The overall score of the B-IFAM presented large correlation coefficients with most subscales (r = 0.52–0.74), supporting construct validity. Discriminant validity demonstrated statistically significant difference in the overall score, aesthetics, and physical impact subscales among female and male children's/adolescents' (p < 0.05). In the conclusion, the B-IFAM overall score and some subscales demonstrated adequate psychometric properties regarding reliability and validity. The study achieved a specific-condition instrument feasible for use on Brazilian children/adolescents who wear fixed orthodontic appliances.

Objective: to analyze the factors related to micro and macro vascular complications in people with type 2 diabetes mellitus. Methods: a documentary survey of 134 patients with type 2 diabetes mellitus. Bivariate statistical analysis (Pearson's Chi-square test and Fisher's test), with statistical significance if p<0.05. Results: the frequency of micro vascular complications was 50.7%, and retinopathy was the most found (61.7%). There was a statistical association between the group with more than 10 years of disease and the presence of retinopathy. Cardiopathy was one of the most frequent macro vascular complications (69.0%). Regarding the use of insulin therapy in mono therapy, there was significance in the presence of nephropathy and vascular disease. Conclusion: results with statistical significance related to the appearance of complications with disease time, highlighting the presence of diabetic retinopathy. It was verified that the lower the schooling, the greater the onset of vascular disease.

Objetivo: analisar os fatores relacionados às complicações micro e macrovasculares em pessoas com Diabetes Mellitus tipo 2. Métodos: pesquisa documental, com 134 prontuários de pessoas com Diabetes Mellitus tipo 2. Realizada análise estatística bivariada (Qui-quadrado de Pearson e teste de Fisher), com significância estatística se p<0,05. Resultados: a frequência de complicações microvasculares foi 50,7%, sendo a retinopatia a mais encontrada (61,7%). Houve associação estatística entre o grupo com mais de 10 anos de doença e a presença de retinopatia. A cardiopatia foi uma das complicações macrovasculares mais frequentes (69,0%). Quanto à utilização de insulinoterapia em monoterapia, houve significância na presença de nefropatia e doença vascular. Conclusão: resultados com significância estatística relacionaram o surgimento de complicações com o tempo de doença, destacando-se a presença de retinopatia diabética. Verificou-se que quanto menor a escolaridade, maior é o surgimento da doença vascular.

INTRODUCTION: Health promotion in neonatal intensive care unit (NICU) can be disclosed from the humanized care to the newborn. OBJECTIVE:The objective was to analyze the nurse's perception about the pain of the newborn through the VAS and PIPP scales during venipuncture. METHOD: Exploratory-descriptive study and observational, held in the NICU of a public hospital in Fortaleza-CE, in may/2010. The subjects were 19 newborns and 18 nurses, venipunctures totaled 54. The collect took place from the systematic observation and non-participatory. RESULTS:There wasn't equivalence in 68.5% of the responses between VAS and PIPP scales values, showing that the perception of nurses regarding pain in neonates is not associated with actual pain demonstrated. IMPLICATIONS ON NURSING: It's necessary that nurses improve their knowledge about pain management and pain scales, thus leading to greater awareness about the pain in the newborn painful procedures.

INTRODUÇÃO: A promoção da saúde na unidade terapia intensiva neonatal (UTIN) pode ser desvelada a partir do cuidado humanizado ao recém-nascido (RN). OBJETIVO: analisar a percepção dos enfermeiros acerca da dor do RN através das escalas VAS e PIPP durante a punção venosa. METODOLOGIA: Estudo exploratório-descritivo e observacional, realizado na UTIN de um Hospital Público de Fortaleza-CE, em maio/2010. Os sujeitos foram 19 recém-nascidos e 18 enfermeiras, as punções venosas totalizaram 54. A coleta realizou-se a partir da observação sistemática e não participativa. RESULTADOS: Os valores com base na PIPP e VAS não demonstraram equivalência entre as respostas em 68,5%, mostrando que a percepção das enfermeiras frente à dor do RN não se relacionou com a dor real demonstrada. IMPLICAÇÕES PARA ENFERMAGEM: a necessidade dos enfermeiros em aprimorar seus conhecimentos sobre o manejo da dor, e por sua vez nas escalas levando assim a uma maior percepção quanto à dor do RN em procedimentos dolorosos.

O objetivo deste trabalho foi determinar os efeitos do 1-MCP na qualidade de goiabas 'Paluma' minimamente processadas, armazenadas a 3ºC. O delineamento estatístico utilizado foi o inteiramente casualizado, em esquema fatorial 3 x 5, com 3 repetições, em que o primeiro fator correspondeu aos tratamentos: testemunha, aplicação de 1.000nL.L-1 de 1-MCP sobre o fruto intacto, antes do corte, e aplicação de 1.000nL.L-1 de 1-MCP no produto processado. O segundo fator foi o tempo de armazenamento (0; 3; 6; 9 e 12 dias) a 3ºC. Cada parcela foi composta por 10 metades. O 1-metilciclopropeno (1-MCP) não afetou a qualidade de goiabas 'Paluma' minimamente processadas e armazenadas a 3ºC, durante 12 dias, na concentração e no período de exposição estudados.

The objective of this work was to determine the effects of 1-MCP in the quality of guava 'Paluma' minimally processed, stored at 3ºC. The experiment was carried out in a completely randomly design, in a 3 x 5 factorial scheme, with 3 replicates, in which the first factor corresponded to the treatments: witness, application of 1000nL.L-1 of 1-MCP on the intact fruit, before cutting and application of 1000nL.L-1 of 1-MCP in the processed product. The second factor was the period of storage (0, 3, 6, 9 and 12 days) at 3ºC. The experimental units were built up with 10 halves of fruits. The 1-MCP did not affect the quality of 'Paluma' guava minimally processed and stored at 3ºC during 12 days, in the studied concentration and period of exposition.

O presente trabalho teve como objetivo avaliar a patogenicidade de Colletotrichum gloeosporioides em frutos de manga, mamão, goiaba e maracujá. A inoculação do C. gloeosporioides foi feita de forma direta, fazendo um furo no fruto e colocando, em seguida, um disco de meio de cultura contendo o micélio do fungo das diferentes espécies. O delineamento experimental utilizado foi inteiramente casualizado, com 25 tratamentos, 3 repetições, sendo as avaliações realizadas por esquema fatorial de 5 x 5. Os resultados obtidos demonstram que todos os isolados apresentam patogenicidade em todas as espécies frutíferas consideradas. A goiaba é o hospedeiro que apresenta menor suscetibilidade aos diversos isolados de C. gloeosporioides. As mangas Tommy Atkins e Rosa e o mamão apresentam o maior crescimento das lesões, portanto maior suscetibilidade.

The present work had as objective to evaluate the pathogenicity of C. gloeosporioides isolated from mango, papaya, guava and passion fruit. The inoculation with C. gloeosporioides was through a direct way, opening a hole on the fruit and inoculating PDA disks with a mycelium of the fungus. The control was inoculated with PDA disks without the fungus. A completely randomized blocks design was used, with 25 treatments and 3 repetitions. A factorial scheme (5 x 5) was used for evaluations. The results obtained demonstrate that all the isolated show pathogenicity in all fruit species studied. Guava is the host, which showed smaller susceptibility to the several isolated of C. gloeosporioides. Tommy Atkins and Rosa Mangoes and also papaya present larger lesions growth, therefore a larger susceptibility.

Invasive infections caused by Candida spp. are an important problem in immunocompromised patients. There is scarce data on the epidemiology of blood stream candidiasis in Salvador, Brazil. This study evaluates the risk factors associated with candidemia, among patients admitted to three tertiary, private hospitals, in Salvador, Brazil. We conducted a case-control, retrospective study to compare patients with diagnosis of candidemia in three different tertiary hospitals in Salvador, Brazil. Patients were matched for nosocomial, acquired infections, according to the causal agent: cases were defined by positive blood cultures for Candida species. Controls were those patients who had a diagnosis of systemic bacterial infection, with a positive blood culture to any bacteria, within the same time period (± 30 days) of case identification. The groups were compared for the main known risk factors for candidemia and for mortality rates. A hundred thirty-eight patients were identified. Among the 69 cases, only 14 were diagnosed as infected by Candida albicans. Candida species were defined in only eight cultures: C. tropicalis (4 cases), C. glabrata, C. parapsilosis, C. guillermondi, C. formata (1 case each). The main risk factors, identified in a univariate analysis, were: presence of a central venous catheter (CVC), use of parenteral nutrition support (PNS), previous exposure to antibiotics, and chronic renal failure (CRF). No association was detected with surgical procedures, diabetes mellitus, neutropenia or malignancies. Patients were more likely to die during the hospitalization period, but the rates of death caused by the infections were similar for cases and controls. The length of hospitalization was similar for both groups, as well as the time for a positive blood culture. Blood stream infection by Candida spp. is associated with CVC, PNS, previous use of antibiotics, and CRF. The higher mortality rate for cases probably better reflects the severity of the underlying diseases, than as a direct consequence of Candidemia.