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Isolation of 4-nerolidylcatechol from leaves of Piper peltatum L., and evaluation of larvicidal activity in mosquito vectors, with emphasis on Aedes aegypti (Diptera: Culicidae) 4nerolidylcatechol nerolidylcatechol 4 L L. vectors Diptera (Diptera Culicidae
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Nascimento, Sara Raquel Lavareda

; Pinto, Ana Cristina da Silva

; Meireles, Sabrina da Fonseca

; Silva, Junielson Soares da

; Chaves, Francisco Celio Maia

; Rafael, Míriam Silva

Revista Brasileira de Entomologia

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2024, Volume 68 Nº 2 elocation e20230074

Resumo: En | Texto: En | PDF: En

ABSTRACT Synthetic chemical insecticides are widely used in population control of pests. Aedes aegypti is the primary vector of dengue, Zika, chikungunya and yellow fever to humans, and has proven resistance to chemical insecticides. As an alternative vector control method, the ethanolic extract of the leaves of Piper peltatum L. (Piperaceae) showed larvicidal activity against Ae. aegypti. Despite the wide medicinal use of this plant, the biological activity of its isolated constituents remains unexplored. In this sense, we isolated, identified and evaluated the larvicidal activity of 4-nerolidylcatechol (4-NC) from P. peltatum against Ae. aegypti, Culex quinquefasciatus and Anopheles darlingi, focusing on the larvicidal, adulticidal and genotoxic potential of 4-NC on Ae. aegypti. Larvae were captured in the city of Manaus, Amazonas state, Brazil. 4-NC was isolated from the extract of the leaves of P. peltatum via silica gel chromatography. This was identified using nuclear magnetic resonance spectroscopy and tested in Artemia franciscana (6.25, 12.5, 25, 50, 100 and 200 µg/mL). In the toxicity bioassay, Ae. aegypti larvae were exposed to 30, 50, 70, 90, and 110 µg/mL of 4-NC, while Cx. quinquefasciatus and An. darlingi were exposed to 6.25, 12.5, 25, 50 and 100 µg/mL. Ae. aegypti larvae were also subjected to 40 and 60 µg/mL of 4-NC (genotoxicity bioassay), and adult females to 62.5 to 1,000 µg/mL (adulticidal bioassay). The results of the 4-NC toxicity assays showed that there was 100% mortality in larvae of Ar. franciscana at the concentration of 200 µg/mL, with an LC50 of 8.0 μg/mL. In the larvae of Ae. aegypti, mortality was 100%, with an LC50 of 62 μg/mL. In larvae of Cx. quinquefasciatus, 97% mortality occurred, with an LC50 of 52.3 μg/mL, and in An. darlingi larvae there was an 83% mortality rate, with an LC50 of 55.8 μg/mL. In adults of Ae. aegypti, however, there was no adulticidal activity. In the larvae of Ae. aegypti, the genotoxic effect of 4-NC (40 and 60 µg/mL) showed significant frequency (p < 0.05) of cellular abnormalities (micronuclei, budding and nuclear bridges) of interphasic nuclei of neuroblasts and oocytes in relation to the negative control. This result may be associated with a decrease in oviposition of females, which was observed in two generations. We can confirm that 4-NC has larvicidal activity against Ae. aegypti, Cx. quinquefasciatus and An. darlingi. Although it does not present adulticidal activity in Ae. aegypti, it reduced the oviposition of females. Therefore, 4-NC seems to be a strong candidate for the development of an alternative method for the control of these mosquitoes in the immature phase. pests dengue Zika humans L Piperaceae (Piperaceae Ae plant unexplored sense 4nerolidylcatechol nerolidylcatechol 4 4NC NC (4-NC P Manaus state Brazil chromatography 625 6 25 (6.25 125 12 5 12.5 10 20 µgmL . µg mL bioassay 30 70 90 11 4NC, NC, Cx An 6.25 genotoxicity , bioassay) 62. 1000 1 000 1,00 bioassay. Ar LC LC5 80 8 0 8. μgmL μg μg/mL 97 occurred 523 52 3 52. 83 rate 558 55 55. however (4 p 0.05 005 05 micronuclei, micronuclei (micronuclei bridges generations Therefore phase 2 (6.2 12. 7 9 6.2 00 1,0 ( 0.0 (6. 6. 1, 0. (6

https://doi.org/10.1590/1806-9665-rbent-2023-0074

New derivatives of dillapiole have ovicidal, larvicidal and adulticidal effect on Aedes (Stegomyia) aegypti (Diptera: Culicidae) ovicidal Stegomyia (Stegomyia Diptera (Diptera Culicidae
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Silva, Junielson Soares da

; Pinto, Ana Cristina da Silva

; Meireles, Sabrina da Fonseca

; Morais, Sirlei Antunes

; Cruz, Daniel Luís Viana

; Chaves, Francisco Célio Maia

; Sousa, João Marcelo de Castro

; Rafael, Míriam Silva

Revista Brasileira de Entomologia

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2024, Volume 68 Nº 4 elocation e20240010

Resumo: En | Texto: En | PDF: En

ABSTRACT The new molecules piperidyl dillapiole and propyl ether dillapiole were evaluated in Aedes aegypti as an alternative for the control of populations of this mosquito. A total of 1,690 samples, comprising 780 eggs, 780 larvae and 130 adults, were treated with both substances for 4 h, 24 h and 90 min, respectively. The dillapiole (80 µg/mL), temephos (0.012 µg/mL) as positive control, and the negative control (water + DMSO 0.05%). The 50% lethal concentrations (LC50) of propyl ether dillapiole and piperidyl dillapiole in eggs were 18.07 and 49.97 µg/mL and, in larvae, the LC50 of these substances were 29.15 and 72.93 µg/mL, which caused darkening of the cuticle and displacement of the head. In the adults, the LC50 of the two substances after 90 min was 148.25 and 263.26 µg/mL, respectively. The insertion of the propyl and piperidine radicals into the dillapiole molecule resulted in the substances propyl ether dillapiole and piperidyl dillapiole, both of which had a toxic effect on Ae. aegypti. However, propyl ether dillapiole, which has propylene in its side chain, showed greater ovicidal, larvicidal and adulticidal activity when compared to piperidyl dillapiole. These results are promising as an alternative form of control of Ae. aegypti, which is the primary vector of human arboviruses. mosquito 1690 1 690 1,69 samples 78 13 adults 2 9 respectively 80 (8 µgmL , µg mL 0.012 0012 0 012 (0.01 water 0.05%. 005 0.05% . 05 0.05%) 50 LC (LC50 1807 18 07 18.0 4997 49 97 49.9 LC5 2915 29 15 29.1 7293 72 93 72.9 head 14825 148 25 148.2 26326 263 26 263.2 Ae However chain ovicidal arboviruses 169 69 1,6 7 8 ( 0.01 001 01 (0.0 00 0.05 5 (LC5 180 18. 499 49. 291 29. 729 72. 1482 14 148. 2632 263. 16 6 1, 0.0 (0. (LC 0. (0

https://doi.org/10.1590/1806-9665-rbent-2024-0010

One-year impact of COVID-19 pandemic on renal replacement therapy and kidney transplantation in a tertiary center in Southern Brazil Oneyear One year COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Teichmann, Pedro do Valle

; Moschetta, Marina Oliboni

; Franco, Rodrigo Fontanive

; Vicari, Alessandra Rosa

; Nunes, Gérson Luiz da Silva

; Lazzaretti, Maria Angela Kalil Nader

; Gomes, Miriam Gressler

; Dorigoni, Silvia Maria

; Dall’Agnol, Paulo Roberto

; Klafke, Adriana

; Thomé, Fernando Saldanha

; Spuldaro, Fabio

; Agra, Homero

; Almeida, Rafael de

; Lara, Darlan Martins

; Bauer, Andrea Carla

; Karhol, Cristina

; Manfro, Roberto Ceratti

Brazilian Journal of Nephrology

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Jun 2023, Volume 45 Nº 2 Páginas 210 - 217

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução: Pacientes em terapia renal substitutiva (TRS) e receptores de transplante renal (RTR) apresentam múltiplos fatores que podem aumentar o risco de óbito por doença do coronavírus 2019 (COVID-19). Este estudo teve como objetivo avaliar incidência e impacto da COVID-19 em pacientes em TRS e RTR. Métodos: Entre Março de 2020 e Fevereiro de 2021, monitoramos a população em TRS de treze unidades de diálise que encaminham pacientes para transplante ao nosso centro, um hospital terciário no Sul do Brasil. No mesmo período, também monitoramos a incidência e mortalidade da COVID-19 em nossa população de RTR. Foram analisadas informações demográficas, clínicas e relacionadas à COVID-19. Resultados: Avaliamos 1545 pacientes nos centros de diálise, dos quais 267 (17,4%) foram infectados pela COVID-19 e 53 (19,9%) foram a óbito. Entre 275 pacientes na lista de espera para transplante renal, 63 (22,9%) foram infectados e sete (11,1%) foram a óbito. COVID-19 foi a principal causa de óbito (29,2%) entre pacientes na lista de espera. Dentre a população de 1360 RTR, 134 (9,85%) foram diagnosticados com COVID-19 e 20 (14,9%) foram a óbito. O número de transplantes renais diminuiu em 56,7% comparado ao mesmo período nos doze meses anteriores. Conclusão: No período do estudo, pacientes em TRS e RTR apresentaram alta incidência de COVID-19 e alta letalidade relacionada à COVID-19. O impacto nos pacientes na lista de espera para transplante foi menos pronunciado. A taxa de letalidade observada em ambas as coortes parece estar relacionada à idade, comorbidades e gravidade da doença. Introdução (TRS (RTR 201 COVID19. COVID19 COVID 19 . (COVID-19) COVID-1 Métodos 202 2021 centro Brasil demográficas 19. Resultados 154 26 17,4% 174 17 4 (17,4% 5 19,9% 199 9 (19,9% 27 6 22,9% 229 22 (22,9% 11,1% 111 11 1 (11,1% 29,2% 292 29 2 (29,2% 136 13 9,85% 985 85 (9,85% 14,9% 149 14 (14,9% 567 56 7 56,7 anteriores Conclusão pronunciado idade COVID1 (COVID-19 COVID- 15 17,4 (17,4 19,9 (19,9 22,9 (22,9 11,1 (11,1 29,2 (29,2 9,85 98 8 (9,85 14,9 (14,9 56, (COVID-1 17, (17, 19, (19, 22, (22, 11, (11, 29, (29, 9,8 (9,8 14, (14, (COVID- (17 (19 (22 (11 (29 9, (9, (14 (COVID (1 (2 (9 (

ABSTRACT Introduction: Patients on renal replacement therapy (RRT) and kidney transplant recipients (KTR) present multiple factors that may increase the risk of death from coronavirus disease 2019 (COVID-19). This study aimed to evaluate the incidence and impact of COVID-19 in RRT patients and KTRs. Methods: Between March 2020 and February 2021, we monitored the RRT population of thirteen dialysis facilities that refer patients for transplantation to our center, a tertiary hospital in Southern Brazil. In the same period, we also monitor COVID-19 incidence and mortality in our KTR population. Demographical, clinical, and COVID-19-related information were analyzed. Results: We evaluated 1545 patients in the dialysis centers, of which 267 (17.4%) were infected by COVID-19 and 53 (19.9%) died. Among 275 patients on the kidney transplant waiting list, 63 patients (22.9%) were infected and seven (11.1%) died. COVID-19 was the leading cause of death (29.2%) among patients on the waiting list. Within the population of 1360 KTR, 134 (9.85%) were diagnosed with COVID-19 and 20 (14.9%) died. The number of kidney transplants decreased by 56.7% compared with the same period in the previous twelve months. Conclusion: In the study period, patients on RRT and KTRs presented a high incidence of COVID-19 and high COVID-19-related lethality. The impact on the patients on the transplant waiting list was less pronounced. The lethality rate observed in both cohorts seems to be related to age, comorbidities, and disease severity. Introduction (RRT (KTR 201 COVID19. COVID19 COVID 19 . (COVID-19) COVID-1 Methods 202 2021 center Brazil Demographical clinical COVID19related COVIDrelated analyzed Results 154 centers 26 17.4% 174 17 4 (17.4% 5 19.9% 199 9 (19.9% died 27 6 22.9% 229 22 (22.9% 11.1% 111 11 1 (11.1% 29.2% 292 29 2 (29.2% 136 13 9.85% 985 85 (9.85% 14.9% 149 14 (14.9% 567 56 7 56.7 months Conclusion pronounced age comorbidities severity COVID1 (COVID-19 COVID- 15 17.4 (17.4 19.9 (19.9 22.9 (22.9 11.1 (11.1 29.2 (29.2 9.85 98 8 (9.85 14.9 (14.9 56. (COVID-1 17. (17. 19. (19. 22. (22. 11. (11. 29. (29. 9.8 (9.8 14. (14. (COVID- (17 (19 (22 (11 (29 9. (9. (14 (COVID (1 (2 (9 (

https://doi.org/10.1590/2175-8239-jbn-2022-0034en

Study of karyotype and constitutive heterochromatin of Mansonia spp. (Diptera: Culicidae) in the area surrounding the Jirau Hydroelectric Dam, Rondônia, Brazil spp Diptera (Diptera Culicidae Dam Rondônia
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Rafael, Míriam Silva

; Meireles, Sabrina da Fonseca

; Ferreira, Vânia da Costa

; Tadei, Wanderli Pedro

; Roque, Rosemary Aparecida

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0095-2022

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Mansonia mosquitoes transmit arboviruses to humans. This study describes the karyotypes and C-banding of Mansonia humeralis, Mansonia titillans, Mansonia pseudotitillans, and Mansonia indubitans. Methods: From the 202 larvae, the brain ganglia were dissected (n=120) for the preparation of slides. Twenty slides with well-distended chromosomes for each species (10 for karyotyping and 10 for C-banding) were selected for further study. Results: The haploid genome and the average lengths of the chromosomal arms differed in relation to the centromere between species, and intraspecific differences also occurred in the distribution of the C-bands. Conclusions: These results are useful for better understanding of the chromosomal variability of Mansonia mosquitoes. Background humans Cbanding C banding humeralis titillans pseudotitillans indubitans Methods 20 larvae n=120 n120 n 120 (n=120 welldistended well distended (1 1 Results Cbands. Cbands bands. bands C-bands Conclusions 2 n=12 n12 12 (n=12 ( n=1 n1 (n=1 n= (n= (n

https://doi.org/10.1590/0037-8682-0095-2022

Phylogenetic relationships of the supercontig of sodium channel subunit I (NaV) in 17 species of Anopheles (Diptera: Culicidae)
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Santos, Valéria Silva

; Bridi, Leticia Cegatti

; Rafael, Míriam Silva

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0701-2021

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Malaria is a global health problem and is transmitted by the Anopheles species. Due to the epidemiological importance of the genus, studies on biological, phylogenetic, and evolutionary aspects have contributed to the understanding of adaptation, vector capacity, and resistance to insecticides. The latter may result from different causes such as mutations in the gene that encodes the sodium channel (NaV). Methods: In this study, the NaV subunit I scaffold of 17 anopheline species was used to infer phylogenetic relationships of the genus Anopheles using Bayesian inference. The evolutionary phylogenetic tree of the NaV gene was aligned in the AliView program and analyzed utilizing Bayesian inference, using the software MrBayes. Results: The anophelines were grouped into five well-supported clusters: 1 - Anopheles darlingi and Anopheles albimanus; 2 - Anopheles sinensis and Anopheles atroparvus; 3 - Anopheles dirus; 4 - Anopheles minimus, Anopheles culicifacies, Anopheles funestus, Anopheles maculatus, and Anopheles stephensi; and 5 - Anopheles christyi, Anopheles epiroticus, Anopheles merus, Anopheles melas, Anopheles gambiae, Anopheles coluzzii, and Anopheles arabiensis. Conclusions: The topology confirms the phylogenetic relationships proposed in studies based on the genome of some anophelines and reflects the current taxonomy of the genus, which suggests that NaV undergoes selection pressure during the evolution of the species. These data are useful tools for inferring their ability to resist insecticides and also help in better understanding the evolutionary processes of the genus Anopheles.

https://doi.org/10.1590/0037-8682-0701-2021

One-year impact of COVID-19 pandemic on renal replacement therapy and kidney transplantation in a tertiary center in Southern Brazil
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Teichmann, Pedro do Valle

; Moschetta, Marina Oliboni

; Franco, Rodrigo Fontanive

; Vicari, Alessandra Rosa

; Nunes, Gérson Luiz da Silva

; Lazzaretti, Maria Angela Kalil Nader

; Gomes, Miriam Gressler

; Dorigoni, Silvia Maria

; Dall’Agnol, Paulo Roberto

; Klafke, Adriana

; Thomé, Fernando Saldanha

; Spuldaro, Fabio

; Agra, Homero

; Almeida, Rafael de

; Lara, Darlan Martins

; Bauer, Andrea Carla

; Karhol, Cristina

; Manfro, Roberto Ceratti

Brazilian Journal of Nephrology

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2022, Nº ahead

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/2175-8239-jbn-2022-0034en

Wanderli Pedro Tadei (★1948 †2021)
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Scarpassa, Vera Margarete

; Santos, Joselita Maria Mendes dos

; Rafael, Míriam Silva

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0388-2021

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/0037-8682-0388-2021 49 downloads

TRI-PONDERAL MASS INDEX IS USEFUL FOR SCREENING CHILDREN AND ADOLESCENTS WITH INSULIN RESISTANCE
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Neves, Felipe Silva

; Alvim, Rafael de Oliveira

; Zaniqueli, Divanei

; Pani, Virgilia Oliveira

; Martins, Caroline Resende

; Peçanha, Marcos Alves de Souza

; Barbosa, Míriam Carmo Rodrigues

; Faria, Eliane Rodrigues de

; Mill, José Geraldo

Revista Paulista de Pediatria

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2020, Volume 38 elocation e2019066

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Investigar se o índice de massa tri-ponderal e os escores-z do índice de massa corporal são equivalentes na triagem de crianças e adolescentes com resistência à insulina. Métodos: Estudo transversal com 296 crianças e adolescentes matriculados em escolas públicas de Vitória, Espírito Santo, Brasil, com idades entre oito e 14 anos. O índice de massa tri-ponderal foi calculado como a razão entre o peso e a altura ao cubo. O índice de massa corporal foi calculado como a razão entre o peso e a altura ao quadrado. A resistência à insulina foi definida pelo modelo de avaliação da homeostase para resistência à insulina (HOMA-IR). Resultados: O HOMA-IR foi maior no 4º quartil dos escores-z do índice de massa corporal e do índice de massa tri-ponderal, em relação ao 1º e 2º quartis em ambos os sexos. As áreas sob as curvas receiver operating characteristic ajustadas por idade foram semelhantes em meninas (escores-z do índice de massa corporal=0,756; índice de massa tri-ponderal=0,763) e meninos (escores-z do índice de massa corporal=0,831; índice de massa tri-ponderal=0,843). Além disso, de acordo com as estimativas das análises de regressão linear simples, os escores-z do índice de massa corporal e o índice de massa tri-ponderal explicaram uma fração significativa da variabilidade do modelo de avaliação da homeostase para meninas (escores-z do índice de massa corporal: R2=0,269; índice de massa tri-ponderal: R2=0,289; p<0,001) e meninos (escores-z do índice de massa corporal: R2=0,175; índice de massa tri-ponderal: R2=0,210; p<0,001). Conclusões: O índice de massa tri-ponderal e os escores-z do índice de massa corporal foram semelhantes na triagem de crianças e adolescentes com resistência à insulina. É importante ressaltar que o uso do índice de massa tri-ponderal é claramente vantajoso, pois pode ser calculado sem ajustes por idade, fato que o torna muito aplicável à prática clínica.

ABSTRACT Objective: To investigate whether tri-ponderal mass index and body mass index Z scores are equivalent for screening children and adolescents with insulin resistance. Methods: Cross-sectional study with 296 children and adolescents enrolled at public schools of Vitória, Espírito Santo, Brazil, aged eight to 14 years. The tri-ponderal mass index was calculated as the ratio between weight and height cubed. The body mass index was calculated as the ratio between weight and height squared. Insulin resistance was defined with the homeostatic model assessment (HOMA-IR). Results: The HOMA-IR was higher in the 4th quartile of body mass index Z scores and tri-ponderal mass index compared to 1st and 2nd quartiles for both girls and boys. The areas under the age-adjusted receiver operating characteristic curves were similar between the indices for girls (body mass index Z scores=0.756; tri-ponderal mass index=0.763) and boys (body mass index Z scores=0.831; tri-ponderal mass index=0.843). In addition, according to the simple linear regression analyses estimations, both body mass index Z scores and tri-ponderal mass index explained a significant fraction of the homeostatic model assessment variability for girls (body mass index Z scores: R2=0.269; tri-ponderal mass index: R2=0.289; p<0.001) and boys (body mass index Z scores: R2=0.175; tri-ponderal mass index: R2=0.210; p<0.001). Conclusions: The tri-ponderal mass index and body mass index Z scores were similar to discriminate children and adolescents with insulin resistance. It is noteworthy that the use of tri-ponderal mass index is clearly advantageous, because it can be calculated with no concerns on adjustments for the age, a fact that makes it very applicable in the clinical practice.

https://doi.org/10.1590/1984-0462/2020/38/2019066 1263 downloads

Genotoxic Effects of Semi-Synthetic Isodillapiole on Oviposition in Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae)
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Santos, Luiz Henrique Fonseca dos

; Domingos, Pedro Rauel Cândido

; Meireles, Sabrina da Fonseca

; Bridi, Leticia Cegatti

; Pinto, Ana Cristina da Silva

; Rafael, Míriam Silva

Revista da Sociedade Brasileira de Medicina Tropical

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2020, Volume 53 elocation e20200467

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: Semi-synthetic dillapiole compounds derived from Piper aduncum essential oil are used as alternative insecticides to control insecticide-resistant Aedes aegypti. Thus, we aimed to evaluate the genotoxic effects of semi-synthetic isodillapiole on the nuclei of neuroblasts (larvae) and oocytes (females) and the mean oviposition rates of the females over four generations (G1, G2, G3, and G4) of Ae. aegypti. METHODS: Larvae were captured in the city of Manaus, Amazonas state, Brazil, and exposed to isodillapiole in bioassays (20, 40, and 60 µg/mL) and a negative control (0.05% DMSO in tap water) for 4 h. The cerebral ganglia were extracted from the larvae and oocytes from the adult females to prepare slides for cytogenetic analysis. Breeding pairs were established and eggs counts were quantified taken after the bioassays. RESULTS: The analysis of 20,000 interphase nuclei of neuroblasts and oocytes indicated significant genotoxicity (micronuclei, budding, polynucleated cells, and other malformations) compared to that of the control. Metaphasic and anaphasic nuclei presented chromosomal breaks; however, no significant variation and damage was observed in the negative control. A significant reduction in mean oviposition rates was also recorded following exposure to isodillapiole over the four generations (G1, G2, G3, and G4). CONCLUSIONS: The toxic and genotoxic effects of isodillapiole on Ae. aegypti were caused by reduced oviposition in the females and nuclear abnormalities over the four generations of the trials. Further studies are required, rather than our in vitro assays, to verify the efficacy of exposure to this compound for controlling Ae. aegypti.

https://doi.org/10.1590/0037-8682-0467-2020 289 downloads

10.

Insect (Hexapoda) diversity in the oceanic archipelago of Fernando de Noronha, Brazil: updated taxonomic checklist and new records
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Rafael, José Albertino

; Limeira-de-Oliveira, Francisco

; Hutchings, Roger William

; Miranda, Gil Felipe Gonçalves

; Silva Neto, Alberto Moreira da

; Somavilla, Alexandre

; Camargo, Alexssandro

; Asenjo, Angélico

; Pinto, Ângelo Parise

; Bello, Ayr de Moura

; Dalmorra, Camila

; Mello-Patiu, Cátia Antunes de

; Carvalho, Claudio José Barros de

; Takiya, Daniela Maeda

; Parizotto, Daniele Regina

; Marques, Dayse Willkenia Almeida

; Cavalheiro, Denis de Oliveira

; Mendes, Diego Matheus de Mello

; Zeppelini, Douglas

; Carneiro, Eduardo

; Lima, Élison Fabrício Bezerra

; Lima, Estevam Cipriano Araújo de

; Godoi, Fabio Siqueira Pitaluga de

; Pessoa, Felipe Arley Costa

; Vaz-de-Mello, Fernando Zagury

; Sosa-Duque, Francisco José

; Flores, Heloísa Fernandes

; Fernandes, Itanna Oliveira

; Silva-Júnior, José Osvaldo

; Gomes, Lucas Roberto Pereira

; Monné, Marcela Laura

; Castro, Marcelo Cutrim Moreira de

; Silva, Marcelo Peixoto Gomes da

; Couri, Márcia Souto

; Gottschalk, Marco Silva

; Soares, Matheus Mickael Mota

; Monné, Miguel Angel

; Rafael, Miriam Silva

; Casagrande, Mirna Martins

; Mielke, Olaf Hermann Hendrik

; Grossi, Paschoal Coelho

; Pinto, Paula Jéssica Costa

; Bartholomay, Pedro Reck

; Sobral, Rafael

; Heleodoro, Raphael Aquino

; Machado, Renato José Pires

; Corrêa, Robson Crepes

; Hutchings, Rosa Sá Gomes

; Ale-Rocha, Rosaly

; Santos, Sandra Duque dos

; Lima, Sheila Pereira de

; Mahlmann, Thiago

; Silva, Vera Cristina

; Fernandes, Daniell Rodrigo Rodrigues

Revista Brasileira de Entomologia

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2020, Volume 64 Nº 3 elocation e20200052

Resumo: En | Texto: En | PDF: En

ABSTRACT Hexapods, commonly known as insects, are a neglected taxonomic group in the Fernando de Noronha archipelago, with unanswered questions about their species richness and the ecological processes in which they are involved (e.g., colonization, introduction, establishment, and extinction). Herein, we provide an updated Hexapod checklist with current nomenclatural combinations. The entomofauna of the Fernando de Noronha archipelago is currently composed of 453 species in 21 orders. The orders, and their respective number of species, are: Blattaria (9), Coleoptera (118), Collembola (29), Dermaptera (3), Diplura (1), Diptera (134), Embioptera (1), Hemiptera (29), Hymenoptera (59), Isoptera (2), Lepidoptera (25), Mantodea (1), Neuroptera (3), Odonata (5), Orthoptera (11), Phasmatodea (1), Phthiraptera (6), Psocoptera (3), Siphonaptera (1), Thysanoptera (10), and Zygentoma (2). The archipelago has 263 new taxon records (family + genera + species). Thirty-eight species (3.39%) were described from local specimens and most of them are likely endemic species. This study more than doubles our knowledge (from the previous 190 records) of the entomofauna in this large Brazilian archipelago. This study also provides a baseline for studies on its conservation status and for implementing future environmental management programs.

https://doi.org/10.1590/1806-9665-rbent-2020-0052 2462 downloads

11.

Waist-to-height ratio is as reliable as biochemical markers to discriminate pediatric insulin resistance
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Alvim, Rafael de Oliveira

; Zaniqueli, Divanei

; Neves, Felipe Silva

; Pani, Virgilia Oliveira

; Martins, Caroline Resende

; Peçanha, Marcos Alves de Souza

; Barbosa, Míriam Carmo Rodrigues

; Faria, Eliane Rodrigues de

; Mill, José Geraldo

Jornal de Pediatria

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Ago 2019, Volume 95 Nº 4 Páginas 428 - 434

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Considerando a importância de incorporar ferramentas simples e de baixo custo no cenário clínico-pediátrico para a triagem de resistência à insulina, o presente estudo buscou investigar se a razão cintura/estatura é comparável a marcadores bioquímicos na discriminação de resistência à insulina em crianças e adolescentes. Métodos: Este estudo transversal envolveu estudantes de nove escolas públicas. No total, 296 crianças e adolescentes, de ambos os sexos, com idades entre 8 e 14 anos, compuseram a amostra. A razão cintura/estatura, o índice triglicerídeos/glicose e a razão triglicerídeos/HDL-C foram determinados de acordo com protocolos padrão. A resistência à insulina foi definida por meio do modelo de avaliação homeostática para resistência insulínica, com ponto de corte ≥ 3.16. Resultados: Idade, índice de massa corporal, frequência de excesso de peso, circunferência da cintura, razão cintura/estatura, insulina, glicemia, modelo de avaliação homeostática para resistência insulínica, triglicerídeos, índice triglicerídeos/glicose e razão triglicerídeos/HDL-C foram maiores entre meninos e meninas com resistência à insulina. Também foram observadas, em ambos os sexos, correlações moderadas de todos os indicadores (razão cintura/estatura, índice triglicerídeos/glicose e razão triglicerídeos/HDL-C) com o modelo de avaliação homeostática para resistência à insulina. As áreas sob as curvas ROC foram semelhantes entre a razão cintura/estatura e os marcadores bioquímicos. Conclusão: Os indicadores forneceram poder discriminatório similar para a resistência à insulina. No entanto, levando em conta o custo-benefício, sugerimos que a razão cintura/estatura pode ser uma ferramenta útil para a triagem de resistência à insulina em populações pediátricas.

Abstract Objective: Given the importance of incorporating simple and low-cost tools into the pediatric clinical setting to provide screening for insulin resistance, the present study sought to investigate whether waist-to-height ratio is comparable to biochemical markers for the discrimination of insulin resistance in children and adolescents. Methods: This cross-sectional study involved students from nine public schools. In total, 296 children and adolescents of both sexes, aged 8 -14 years, composed the sample. Waist-to-height ratio, triglycerides/glucose index, and triglycerides-to-HDL-C ratio were determined according to standard protocols. Insulin resistance was defined as homeostatic model assessment for insulin resistance with cut-off point ≥ 3.16. Results: Age, body mass index, frequency of overweight, waist circumference, waist-to-height ratio, insulin, glucose, homeostatic model assessment for insulin resistance, triglycerides, triglycerides/glucose index, and triglycerides-to-HDL-C were higher among insulin resistant boys and girls. Moderate correlation of all indicators (waist-to-height ratio, triglycerides/glucose index, and triglycerides-to-HDL-C ratio) with homeostatic model assessment for insulin resistance was observed for both sexes. The areas under the receiver operational characteristic curves ware similar between waist-to-height ratio and biochemical markers. Conclusion: The indicators provided similar discriminatory power for insulin resistance. However, taking into account the cost-benefit ratio, we suggest that waist-to-height ratio may be a useful tool to provide screening for insulin resistance in pediatric populations.

https://doi.org/10.1016/j.jped.2018.04.004 810 downloads

12.

Macrofauna Edáfica como Indicadora em Revegetação com Leguminosas Arbóreas
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Bianchi, Miriam de Oliveira

; Scoriza, Rafael Nogueira

; Resende, Alexander Silva de

; Campello, Eduardo Francia Carneiro

; Correia, Maria Elizabeth Fernandes

; Silva, Eliane Maria Ribeiro da

Floresta e Ambiente

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2017, Volume 24 elocation e00085714

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O trabalho foi desenvolvido em uma área de pasto abandonada revegetada com leguminosas arbóreas. Localizada no município de Valença, RJ, nela foram utilizadas diferentes proporções de leguminosas arbóreas fixadoras de nitrogênio: 0% (0L), 25% (25L), 50% (50L) e 75% (75L). Para avaliação da macrofauna do solo, as amostragens foram feitas nas épocas seca e úmida, utilizando-se o método TSBF. Outras amostragens foram realizadas, ainda, em uma floresta secundária (FS) e em duas áreas de pasto (PA e PB). O processo de revegetação aumentou a diversidade da fauna do solo de uma forma geral. Formicidae foi o grupo da macrofauna de maior abundância em todas as áreas, para as duas épocas de avaliação. Na época chuvosa, houve aumento considerável na quantidade de invertebrados na camada serapilheira nos tratamentos 0L, 25L, 50L, 75L e Floresta Secundária, o que no período seco aconteceu na camada 0-10 cm.

ABSTRACT The study was conducted in an area of abandoned pasture located in the city of Valença (RJ) revegetated with tree legumes. Different proportions of nitrogen-fixing leguminous trees were used: 0% (0L), 25% (25L), 50% (50L) and 75% (75L). For evaluation of soil biota, samplings were made in the end of the dry season and in the rainy season. Samples were collected in the abandoned pasture, in a secondary forest, and in two grassland areas (PA and PB). The process of reforestation has increased the overall diversity of soil fauna. Formicidae was the group that stood out, being abundant in all treatments and in the two periods of collection. During the rainy season, a considerable increase in the amount of invertebrates in the litter layer was observed in the treatments 0L, 25L, 50L, 75L and in the secondary forest, while during the dry season, such increase occurred in the 0-10 cm layer.

https://doi.org/10.1590/2179-8087.085714 1259 downloads

13.

Does low serum TSH within the normal range have negative impact on physical exercise capacity and quality of life of healthy elderly people?
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Chachamovitz, Dhiãnah Santini de Oliveira

; Vigário, Patrícia dos Santos

; Carvalho, Rafael Cavalcante

; Silvestre, Diego Henrique da Silva

; Moerbeck, Ana Eduarda Vieira

; Soffientini, Mariana Guimarães

; Luna, Érika Luciana Gomes

; Rosemberg, Clara Werner

; Mainenti, Míriam Raquel Meira

; Vaisman, Mário

; Teixeira, Patricia de Fátima dos Santos

Archives of Endocrinology and Metabolism

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Jun 2016, Volume 60 Nº 3 Páginas 236 - 245

Resumo: En | Texto: En | PDF: En

Objective Investigate the differences in cardiopulmonary (CP) capacity and Quality of Life (QOL) between healthy elderly (≥ 65 years) with different TSH levels (< 1.0 and ≥ 1.0 μIU/mL) both within the normal range. Also, evaluate the effects of TSH elevation on CP test and QOL, by administering methimazole to subjects with initial lower-normal TSH, in order to elevate it to superior-normal limit. Materials and methods Initially, a cross-sectional study was performed to compare CP capacity at peak exercise and QOL (using WHOQOL-OLD questionnaire) between healthy seniors (age ≥ 65 years) with TSH < 1.0 μIU/mL vs. TSH ≥1.0 μIU/mL. In the second phase, participants with TSH < 1.0 μIU/mL were included in a non-controlled-prospective-interventional study to investigate the effect of TSH elevation, using methimazole, on QOL and CP capacity at peak exercise. Results From 89 elderly evaluated, 75 had TSH ≥ 1 μIU/mL and 14 TSH < 1 μIU/mL. The two groups had similar basal clinical characteristics. No difference in WHOQOL-OLD scores was observed between groups and they did not differ in terms of CP function at peak exercise. QOL and CP variables were not correlated with TSH levels. Twelve of 14 participants with TSH < 1.0 μIU/mL entered in the prospective study. After one year, no significant differences in clinical caracteristics, QOL, and CP variables were detected in paired analysis before and after methimazole intervention. Conclusions We found no differences in CP capacity and QOL between health elderly with different TSH levels within normal range and no impact after one year of methimazole treatment. More prospective-controlled-randomized studies are necessary to confirm or not the possible harm effect in normal low TSH.

https://doi.org/10.1590/2359-3997000000079 4716 downloads

14.

Evaluación nutricional de niños con insuficiencia renal aguda que reciben diálisis
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Silva Ferrera, Jorge

; Torres Garbey, Miriam

; Arias García, José Rafael

; Gomes Mejías, Juana E

Revista Cubana de Pediatría

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Mar 2010, Volume 82 Nº 1

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

INTRODUCTION: Acute renal insufficiency appears in hours or in a few days and during its course there is a deterioration of patient nutritional status. The aim of present study was to characterize the nutritional status of children with this disease requiring renal replacement therapies. METHODS: A crossed-sectional and retrospective study was conducted including the patients admitted due to acute renal insufficiency in two children hospitals of Santiago de Cuba from December, 2006 to December, 2008. Authors analyzed the age, sex, etiology, renal replacement therapy, cause of parenteral feeding use, nutritional assessment according to Cuban percentile tables and anthropometry parameters (age, weight, height) and parenteral nutrients support. RESULTS: Prerenal events were the cause of acute renal insufficiency in the 44,4% of cases and renal and postrenal ones in the 33,4% and 22,2%, respectively. As a renal depuration method we used the peritoneal dialysis in the 66,6% of cases and the hemodialysis in remainder. The main causes that justified the parenteral feeding were the surgical affections, hypercatabolic states, the digestive hemorrhage and the pancreatitis in a decreasing order. Four patients were assessed as of low weight. CONCLUSIONS: The average support of proteins and lipids was under the established nutritional supports and that of kilocalories was higher than recommended. It is essential to improve these parameters in the treatment of these patients.

INTRODUCCIÓN. La insuficiencia renal aguda se produce en horas o en algunos días, y durante su evolución se produce un deterioro del estado nutricional del paciente. El objetivo de este estudio fue caracterizar el estado nutricional de niños con esta enfermedad que requirieron terapias de reemplazo renal. MÉTODOS. Se realizó un estudio retrospectivo y transversal que incluyó a los pacientes ingresados por insuficiencia renal aguda en dos hospitales pediátricos de Santiago de Cuba entre diciembre de 2006 y diciembre de 2008. Se analizó edad, sexo, etiología, terapia de reemplazo renal, causa del uso de nutrición parenteral, evaluación nutricional según tablas cubanas de percentiles y parámetros antropométricos (edad, peso, talla) y aporte de nutrientes parenterales. RESULTADOS. Eventos prerrenales fueron la causa de la insuficiencia renal aguda en el 44,4 % de los casos, y renales y posrenales, en el 33,4 y 22,2 %, respectivamente. Como método de depuración renal se utilizó la diálisis peritoneal en el 66,6 % de los casos y la hemodiálisis en los restantes pacientes. Las principales causas que motivaron la nutrición parenteral fueron las afecciones quirúrgicas, los estados hipercatabólicos, la hemorragia digestiva y la pancreatitis, en orden decreciente. Cuatro pacientes fueron evaluados como de bajo peso. CONCLUSIONES. El aporte promedio de proteínas y lípidos estuvo por debajo de los aportes nutricionales establecidos, y el aporte de kilocalorías fue superior a lo recomendado. Se deben mejorar estos parámetros en el tratamiento de estos pacientes.

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15.

Location of ribosomal genes in the chromosomes of Anopheles darlingi and Anopheles nuneztovari (Diptera, Culicidae) from the Brazilian Amazon
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Rafael, Míriam Silva

; Tadei, Wanderli Pedro

; Recco-Pimentel, Shirlei Maria

Memórias do Instituto Oswaldo Cruz

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Jul 2003, Volume 98 Nº 5 Páginas 629 - 635

Resumo: En | Texto: En | PDF: En

Fluorescence in situ hybridization of Anopheles darlingi and A. nuneztovari demonstrated nucleolar organizer region activity at the end of the fourth larval instar, when the nucleolar organizer regions underwent gradual condensation. The heteromorphic sex chromosomes showed intraindividual size variation in the rDNA blocks located in the pericentromeric region and this coincided with the location of constitutive heterochromatin (C-banding).

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