ABSTRACT Purpose: This study aimed to compare the safety and effectiveness of intraocular pressure reduction between micropulse transscleral cyclophotocoagulation and “slow cook” transscleral cyclophotocoagulation in patients with refractory primary open-angle glaucoma. Methods: We included patients with primary open angle glaucoma with at least 12 months of follow-up. We collected and analyzed data on the preoperative characteristics and postoperative outcomes. The primary outcomes were a reduction of ≥20% of the baseline value (criterion A) and/or intraocular pressure between 6 and 21 mmHg (criterion B). Results: We included 128 eyes with primary open-angle glaucoma. The preoperative mean intraocular pressure was 25.53 ± 6.40 and 35.02 ± 12.57 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The mean intraocular pressure was reduced significantly to 14.33 ± 3.40 and 15.37 ± 5.85 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups at the last follow-up, respectively (p=0.110). The mean intraocular pressure reduction at 12 months was 11.20 ± 11.46 and 19.65 ± 13.22 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The median preoperative logMAR visual acuity was 0.52 ± 0.69 and 1.75 ± 1.04 in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The mean visual acuity variation was −0.10 ± 0.35 and −0.074 ± 0.16 in the micropulse- and “slow cook” transscleral cyclophotocoagulation, respectively (p=0.510). Preoperatively, the mean eye drops were 3.44 ± 1.38 and 2.89 ± 0.68 drugs in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p=0.017), but those were 2.06 ± 1.42 and 1.02 ± 1.46 at the end of the study in the “slow cook” and micropulse transscleral cyclophotocoagulation groups, respectively (p<0.001). The success of criterion A was not significant between both groups. Compared with 11 eyes (17.74%) in the “slow cook” transscleral cyclophotocoagulation group, 19 eyes (28.78%) in the micropulse transscleral cyclophotocoagulation group showed complete success (p=0.171). For criterion B, 28 (42.42%) and 2 eyes (3.22%) showed complete success after micropulse- and “slow cook” transscleral cyclophotocoagulation, respectively (p<0.001). Conclusion: Both techniques reduced intraocular pressure effectively. Purpose slow cook openangle Methods 1 followup. followup follow up. up follow-up 20 ≥20 andor or B. B . B) Results 2553 25 53 25.5 640 40 6.4 3502 35 02 35.0 1257 57 12.5 p<0.001. p0001 p p<0.001 0 001 (p<0.001) 1433 14 33 14.3 340 3 3.4 1537 15 37 15.3 585 5 85 5.8 followup, up, p=0.110. p0110 p=0.110 110 (p=0.110) 1120 11.2 1146 46 11.4 1965 65 19.6 1322 13 22 13.2 052 52 0.5 069 69 0.6 175 75 1.7 104 04 1.0 010 10 −0.1 035 0.3 0074 074 −0.07 016 16 0.1 p=0.510. p0510 p=0.510 510 (p=0.510) Preoperatively 344 44 138 38 1.3 289 89 2.8 068 68 p=0.017, p0017 p=0.017 , 017 (p=0.017) 206 06 2.0 142 42 1.4 102 146 17.74% 1774 17 74 (17.74% 28.78% 2878 78 (28.78% p=0.171. p0171 p=0.171 171 (p=0.171) 42.42% 4242 (42.42% 3.22% 322 (3.22% Conclusion effectively ≥2 255 25. 64 4 6. 350 35. 125 12. p000 p<0.00 00 (p<0.001 143 14. 34 3. 153 15. 58 8 5. p011 p=0.11 (p=0.110 112 11. 114 196 19. 132 13. 05 0. 7 1. 01 −0. 03 007 07 −0.0 p051 p=0.51 51 (p=0.510 2. p001 p=0.01 (p=0.017 17.74 177 (17.74 28.78 287 (28.78 p017 p=0.17 (p=0.171 42.42 424 (42.42 3.22 32 (3.22 ≥ p00 p<0.0 (p<0.00 p01 p=0.1 (p=0.11 −0 p05 p=0.5 (p=0.51 p=0.0 (p=0.01 17.7 (17.7 28.7 (28.7 (p=0.17 42.4 (42.4 3.2 (3.2 p0 p<0. (p<0.0 p=0. (p=0.1 − (p=0.5 (p=0.0 17. (17. 28. (28. 42. (42. (3. p<0 (p<0. p=0 (p=0. (17 (28 (42 (3 p< (p<0 p= (p=0 (1 (2 (4 ( (p< (p= (p

Abstract This article presents a formulation for the optimization problem that minimizes the CO2 emission of pile caps with variations of geometry and pile position. The problem is defined by the design variables: concrete pile cap dimensions, rebar ratio, concrete compressive strength, the number of piles, the diameter, and length. The environmental impact was chosen as the objective function, taking CO2 emission as the main parameter. The design procedure was based on the ABNT NBR 6118:2014 (2014), and by the formulation proposed by Blévot & Frémy (1967). Also, the soil structure interaction between the cap and the piles was considered in the optimization problem. The problem was implemented using MATLAB (2016) and solved via a Genetic Algorithm native to the program. Results obtained from numerical examples were compared with structural designs solutions located in the Grande Vitória metropolitan area, Espírito Santo, Brazil and validated with a commercial software. The analyses indicate that design optimizations of pile caps considering the compressive strength of concrete, the diameter and length of piles and the optimal geometry of the pile caps may lead to significant reductions of material consumption, and consequently, a reduction of environmental impacts. CO position variables dimensions ratio function parameter 61182014 6118 2014 6118:201 2014, , (2014) 1967. 1967 . (1967) Also 2016 (2016 program area Santo software consumption consequently impacts 6118201 611 201 6118:20 (2014 196 (1967 (201 611820 61 20 6118:2 19 (196 (20 61182 6 2 6118: 1 (19 (2 (1 (

ABSTRACT Agroecological management is considered a model of sustainable agriculture that offers social, environmental and economic benefits. The hypotheses of this study were that agroecological production systems can promote changes in the physical fractions of soil organic matter (SOM) associated with aggregates of different origins, and that the greater diversity of plant species in the production system may favour an increase in the carbon concentration of these aggregates. The aim of this study was to a) determine the mass of the free light fraction (FLF), intra-aggregate light fraction (ILF) and light organic matter fraction (LOM) of biogenic and physiogenic soil aggregates; and b) quantify the organic carbon content of the three light SOM fractions and the residual particulate SOM fraction. Five production systems were evaluated: AgF - Agroforestry system; CSun - Coffee grown in full sun; CSha - Coffee grown in shade; FLE - Flemingia grown in alleys; and NT - No-tillage. The aggregates were separated, identified and classified according to their origin or formation pathway into biogenic (formed by biological processes) or physiogenic aggregates (resulting from chemical and physical actions). From these, the mass and carbon content of the FLF, ILF, LOM and residual particulate fractions were quantified. The greater diversity of plant species found in the AgF system has not yet favoured an increase in the carbon content of the aggregates. The longer set-up time and the management practices of the CSun system has led to an increase in the carbon content of the organic fractions of the aggregates (3.44-1.63 g kg-1 for C-LOM; 1.93-1.13 g kg-1 for C-FLF). The lowest overall mean values for LOM and ILF were found mainly in the aggregates of the NT system (1.22-1.67 and 1.55-2.20 g kg-1, respectively), being associated with the shorter time and greater mobilisation of the arable layer. Biogenic aggregation afforded the highest overall mean values for LOM, and increased the mass of the light fractions (15.5%-27.8% for FLF; 23.4%-8.0% for ILF) and the carbon in the C-LOM, C-FLF and residual particulate fractions (42.3%, 12.9%, and 35.0%, respectively) in the surface layer, suggesting an improvement in soil quality. social benefits (SOM origins FLF , (FLF) intraaggregate intra aggregate (ILF (LOM b evaluated sun shade alleys Notillage. Notillage No tillage. tillage No-tillage separated formed processes resulting actions. actions . actions) quantified setup set up 3.441.63 344163 3.44 1.63 3 44 1 63 (3.44-1.6 kg1 kg kg- CLOM C C-LOM 1.931.13 193113 1.93 1.13 93 13 1.93-1.1 CFLF. CFLF C-FLF) 1.221.67 122167 1.22 1.67 22 67 (1.22-1.6 1.552.20 155220 1.55 2.20 55 2 20 1.55-2.2 kg1, 1, respectively, respectively layer 15.5%27.8% 155278 15.5% 27.8% 15 5 27 8 (15.5%-27.8 23.4%8.0% 23480 23.4% 8.0% 23 4 0 23.4%-8.0 CLOM, 42.3%, 423 42 (42.3% 129 12 9 12.9% 350 35 35.0% quality (FLF 441 3.441.6 34416 344 3.4 163 1.6 6 (3.44-1. 931 1.931.1 19311 193 1.9 113 1.1 1.93-1. 221 1.221.6 12216 122 1.2 167 (1.22-1. 552 1.552.2 15522 155 1.5 220 2.2 1.55-2. 15.5%27.8 15527 15.5 278 27.8 (15.5%-27. 23.4%8.0 2348 234 23.4 80 8.0 23.4%-8. 42.3% (42.3 12.9 35.0 3.441. 3441 34 3. 16 1. (3.44-1 1.931. 1931 19 11 1.93-1 1.221. 1221 (1.22-1 1.552. 1552 2. 1.55-2 15.5%27. 15. 27. (15.5%-27 23.4%8. 23. 8. 23.4%-8 42.3 (42. 12. 35. 3.441 (3.44- 1.931 1.93- 1.221 (1.22- 1.552 1.55- 15.5%27 (15.5%-2 23.4%8 23.4%- 42. (42 (3.44 (1.22 15.5%2 (15.5%- (4 (3.4 (1.2 (15.5% ( (3. (1. (15.5 (3 (1 (15. (15

ABSTRACT Leaf litter decomposition and the release of nutrients from macauba palm leaves play a major role in nutrient return to the soil in a conservation environment. This study evaluated macauba palm leaf decomposition, macronutrient contents and biochemical composition under contrasting water conditions in the Brazilian Cerrado. Macauba leaves were collected from plants in two different environments (low and high water table conditions), placed in litter bags and evaluated according to their decomposition, macronutrients, lignin, cellulose and hemicellulose for 420 days. In addition, green and dry leaves were collected for macronutrient analyses. Litter decomposition ranged between 49 % and 59 % up to 180 days. The half-life of litter ranged from 141 to 198 days. The leaf litter decomposition of macauba was practically stable during the dry season, whereas at the beginning of the rainy season, decomposition resumed. Nitrogen, P and S were higher in the green leaves, whereas the Ca levels were higher in the dry leaves. In addition, the K levels were twofold higher in the green leaves than in the dry leaves. Lignin release from macauba residues was slower than cellulose and hemicellulose. The decomposition rates of hemicellulose were higher initially due to its high solubility, although it gradually decreased with the decomposition process. Lignin decomposition was also higher at the beginning of the process but stabilized during the drought period. The study indicates that the decomposition process and nutrient cycling of macauba are influenced by its biochemical composition. environment Cerrado low conditions, , conditions) macronutrients lignin 42 days addition analyses 4 5 18 halflife half life 14 19 season resumed Nitrogen solubility period 1

ABSTRACT High-sugar dehydrated foods have strong hygroscopicity, which can be avoided by using drying aids. One way to assess the hygroscopic behavior is through sorption isotherms. The objective of this work was to evaluate the influence of maltodextrin concentration on sorption isotherms of powdered cajá-manga pulp in spray-dryer, lyophilization and fluidized bed spray drying processes. The dryings were carried out in a spray-dryer, lyophilizer and fluidized bed, with 10%, 20% and 30% of maltodextrin. Adsorption isotherms were determined by the static gravimetric method using salt solutions for a relative humidity range of 21% to 90%. The GAB, BET, Henderson, and Oswin models were adequate to the experimental data. The relative deviation between the experimental values and the estimated values was calculated for each curve, in order to assess which equation best fit the experimental data. The mean relative error value of less than 10% was considered one of the criteria for selecting the models. The BET (A), BET (B) and GAB (C) models had the lowest error means, 3.35%, 3.35% and 5.28%, for cajá-manga powders obtained by spray-dryer, lyophilization and fluidized bed spray drying processes, respectively, and coefficients of determination above 0.99. It is concluded that the type of drying process did not influence the behavior of the adsorption isotherms, and that increases in maltodextrin concentration and temperature are significant in reducing equilibrium moisture contents. Highsugar High sugar hygroscopicity aids cajámanga cajá manga spraydryer, spraydryer dryer, dryer spray-dryer processes 10 20 30 21 90 90% Henderson data curve A, A , (A) B (B C (C means 335 3 35 3.35 528 5 28 5.28% respectively 099 0 99 0.99 contents 1 2 9 (A 33 3.3 52 5.28 09 0.9 3. 5.2 0. 5.

Abstract Researchers must decide on how they will model the non-linear material response in a Finite Element simulation to assess seismic vulnerability. This paper aims at giving an insight into these modelling decisions by comparing Fiber and Lumped Plasticity Finite Element Models in static and dynamic non-linear analysis in a RC frame. The methodology is based on the performance-based earthquake engineering to determine the expected damage on structures. The results indicate that both models are in good agreement with the static analysis, and when considering Extensive and Complete Damage Limit States on the dynamic analysis. The choice between them depends on the main goals of the research and resources available, since they have a significant difference in processing time. nonlinear non linear vulnerability frame performancebased performance structures available time

Resumo Pesquisadores devem decidir sobre como modelar a resposta não linear do material em uma simulação com Elementos Finitos para avaliar a vulnerabilidade sísmica. Esse trabalho pretende auxiliar nessa tomada de decisão ao comparar os modelos de Fibra e de Plasticidade Concentrada em Elementos Finitos em análises não lineares estáticas e dinâmicas de um pórtico em concreto armado. A metodologia é baseada na engenharia de desempenho sísmico (PBEE) para determinar o dano nas estruturas. Os resultados indicam que os dois modelos apresentam uma boa correspondência em uma análise estática, e ao considerar os Estados Limite de Dano Extensivo e Completo na análise dinâmica. A escolha entre os dois depende dos objetivos principais do pesquisador e dos recursos disponíveis, já que eles apresentam uma significativa diferença no tempo de processamento. sísmica armado PBEE (PBEE estruturas estática dinâmica disponíveis processamento

ABSTRACT OBJECTIVE To present the results of a cost analysis of remote consultations (teleconsultations) compared to in-person consultations for patients with type 2 diabetes, in the Brazilian public healthcare system (SUS) in the city of Joinville, Santa Catarina (SC). In addition to the costs from the local manager’s perspective, the article also presents estimates from the patient’s perspective, based on the transportation costs associated with each type of consultation. METHOD Data were collected from 246 consultations, both remote and in-person, between 2021 and 2023, in the context of a randomized clinical trial on the impact of teleconsultation carried out in the city of Joinville, SC. Teleconsultations were carried out at Primary Health Units (PHU) and in-person consultations at the Specialized Health Center. The consultation costs were calculate by the method time and activity-based costing (TDABC), and for the estimate of transportation costs data was collected directly from the research participants . The mean costs and time required to carry out each type of consultation in different scenarios and perspectives were analyzed and compared descriptively. RESULTS Considering only the local SUS manager’s perspective, the costs for carrying out a teleconsultation were 4.5% higher than for an in-person consultation. However, when considering the transportation costs associated with each patient, the estimated value of the in-person consultation becomes 7.7% higher and, in the case of consultations in other municipalities, 15% higher than the teleconsultation. CONCLUSION The results demonstrate that the incorporation of teleconsultation within the SUS can bring economic advantages depending on the perspective and scenario considered, in addition to being a strategy with the potential to increase access to specialized care in the public network. teleconsultations (teleconsultations inperson person diabetes (SUS Joinville SC (SC) managers manager s patient 24 inperson, person, 202 2023 PHU (PHU Center activitybased activity TDABC, TDABC , (TDABC) descriptively 45 4 5 4.5 However 77 7 7.7 municipalities 15 considered network (SC 20 (TDABC 4. 7. 1

RESUMO OBJETIVO Apresentar os resultados da análise de custos para a modalidade de consulta remota (teleconsulta) em comparação à consulta presencial, em pacientes com diabetes do tipo 2, no Sistema Único de Saúde (SUS) brasileiro, na cidade Joinville, Santa Catarina. Para além dos custos, sob a perspectiva do gestor local, o artigo também apresenta estimativas sob perspectiva do paciente, a partir dos custos de transporte associados a cada modalidade de consulta. MÉTODO Foram coletados dados de 246 consultas, remotas e presenciais, entre 2021 e 2023, no contexto de um ensaio clínico randomizado sobre o impacto da teleconsulta realizado na cidade de Joinville, SC. As teleconsultas foram realizadas em Unidades Básicas de Saúde (UBS) e as consultas presenciais no Centro de Saúde Especializada. Para o cálculo dos custos, foi utilizado o método de custos baseado em tempo e atividade (TDABC) e, para o cálculo dos custos relativos aos transportes dos pacientes, foram coletados dados diretamente com os participantes da pesquisa. Foram analisados e comparados descritivamente os custos médios e o tempo de realização de cada modalidade de consulta em diferentes cenários e perspectivas. RESULTADOS Considerando apenas a perspectiva do gestor local do SUS, os custos para a realização da teleconsulta se mostraram 4,5% maiores do que para uma consulta presencial. Contudo, quando considerados os custos de transporte associados a cada paciente, o valor estimado da consulta presencial passa a ser 7,7% maior e, no caso de consultas em outros municípios, 15% maior do que a teleconsulta. CONCLUSÃO Os resultados demonstram que a incorporação da teleconsulta dentro do SUS pode trazer vantagens econômicas, a depender da perspectiva e do cenário considerado, além de ser uma estratégia com potencial para aumentar o acesso à atenção especializada na rede pública. (teleconsulta 2 (SUS brasileiro Joinville Catarina paciente 24 202 2023 SC UBS (UBS Especializada TDABC (TDABC pesquisa perspectivas 45 4 5 4,5 Contudo 77 7 7,7 municípios 15 econômicas considerado pública 20 4, 7, 1

ABSTRACT Considering the expressive number of commercial soybean cultivars available for cultivation in Brazil and the constant search for improvements in the production system, the objective was to evaluate the productive components and grain yield and to estimate the correlation between them in soybean cultivars sown in the northwest region of Rio Grande do Sul, during the 2019/20 harvest. Sixteen commercial soybean cultivars were sown under their respective plant density recommendations, in a randomized block design with three replications. At the end of the cultivation cycle, the following variables were evaluated: plant height; height of insertion of the first pod; number of nodes; number of pods with one, two, three and four grains; pods per plant; grains per plant; weight of thousand grains, and; grain yield. The cultivars BMX ZEUS IPRO, NS 5445 IPRO and NS 5700 IPRO presented the highest grain yields, mainly due to the high relationship between the number of pods and grains per plant and the weight of a thousand grains. The indirect selection of more productive genotypes can be carried out through the variables weight of thousand grains, number of pods, grains and nodes per plant, given the significant positive correlation between them. system Sul 201920 2019 20 2019/2 harvest recommendations replications cycle evaluated pod one two 544 570 yields 20192 201 2 2019/ 54 57 5

ABSTRACT: This study aimed to prepare and characterize Nile tilapia (Oreochromis niloticus) waste meal. The experimental design consisted of three treatments (carcass meal, mechanically separated meat meal - MSM, and head meal) and five replications of each treatment. Yield, microbiological quality, pH, water activity, proximate composition, energy value, mineral composition, fatty acid profile, amino acid composition, color, and particle size fractions and the geometric mean particle diameter (GMD) analyses were performed. Data were subjected to ANOVA, and means were compared by Tukey’s test at P < 0.05. Carcass, mechanically separated meat, and head meals had a protein content of 56.45%, 78.60%, and 50.33%, respectively, a lipid content of 7.16%, 13.15%, and 4.58%, respectively, and an ash content of 32.61%, 4.26%, and 38.41%, respectively. The mean yield of fish waste meals was 13%. Oleic, palmitic, and linoleic acids were the major fatty acids in the three fish waste meals, and glutamic acid, leucine, lysine, and glycine were the major amino acids. Color analysis showed that lightness (L*) ranged from 55.32 to 77.19, redness (a*) from 4.44 to 4.88, and yellowness (b*) from 4.13 to 9.51. The GMD ranged from 0.37 to 0.99 mm. The results indicate that Nile tilapia waste meals have high nutritional value and adequate pH, water activity, and microbiological quality for use in human nutrition. ABSTRACT Oreochromis niloticus carcass MSM treatment Yield pH activity composition profile color (GMD performed ANOVA Tukeys Tukey s 005 0 05 0.05 Carcass 5645 56 45 56.45% 7860 78 60 78.60% 5033 50 33 50.33% respectively 716 7 16 7.16% 1315 13 15 13.15% 458 4 58 4.58% 3261 32 61 32.61% 426 26 4.26% 3841 38 41 38.41% 13% Oleic palmitic leucine lysine L* L (L* 5532 55 55.3 7719 77 19 77.19 a* (a* 444 44 4.4 488 88 4.88 b* b (b* 413 4.1 951 9 51 9.51 037 37 0.3 099 99 0.9 mm nutrition 00 0.0 564 5 56.45 786 6 78.60 503 3 50.33 71 1 7.16 131 13.15 4.58 326 32.61 42 2 4.26 384 38.41 (L 553 55. 771 77.1 (a 4. 48 8 4.8 (b 95 9.5 03 0. 09 56.4 78.6 50.3 7.1 13.1 4.5 32.6 4.2 38.4 77. 9. 56. 78. 50. 7. 13. 32. 38.

RESUMO: Este estudo teve como objetivo preparar e caracterizar farinha de resíduos de tilápia do Nilo (Oreochromis niloticus). O delineamento experimental consistiu em três tratamentos, farinha de carcaça, farinha de carne mecanicamente separada - CMS e farinha de cabeça, e cinco replicatas por tratamento. Foram realizadas análises de rendimento, qualidade microbiológica, pH, atividade de água, composição centesimal, valor energético, composição mineral, perfil de ácidos graxos, composição de aminoácidos, cor, frações granulométricas e o diâmetro médio geométrico das partículas (DMG). Os dados foram submetidos à ANOVA e as médias comparadas pelo teste de Tukey (P < 0,05). As farinhas de carcaça, de carne mecanicamente separada e de cabeça apresentaram teor de proteína de 56,45%, 78,60% e 50,33%, respectivamente, teor de lipídios de 7,16%, 13,15% e 4,58%, respectivamente, e teor de cinzas de 32,61%. 4,26% e 38,41%, respectivamente. O rendimento médio das farinhas de resíduos de peixe foi de 13%. Os ácidos oleico, palmítico e linoleico foram os principais ácidos graxos encontrados nas três farinhas de resíduos de peixe, e o ácido glutâmico, leucina, lisina e glicina foram os principais aminoácidos detectados nas farinhas. A análise de cor mostrou que a luminosidade (L*) variou de 55,32 a 77,19, o vermelho (a*) variou de 4,44 a 4,88 e o amarelo (b*) variou de 4,13 a 9,51. O GMD variou de 0,37 a 0,99 mm. Os resultados indicam que as farinhas de resíduos de tilápia do Nilo apresentam alto valor nutricional e pH, atividade de água e qualidade microbiológica adequados para uso na alimentação humana. RESUMO Oreochromis niloticus. niloticus . niloticus) tratamentos carcaça tratamento pH centesimal energético mineral DMG. DMG (DMG) P 0,05. 005 0,05 0 05 0,05) 5645 56 45 56,45% 7860 78 60 78,60 5033 50 33 50,33% respectivamente 716 7 16 7,16% 1315 13 15 13,15 458 4 58 4,58% 3261 32 61 32,61% 426 26 4,26 3841 38 41 38,41% 13% oleico glutâmico leucina L* L (L* 5532 55 55,3 7719 77 19 77,19 a* (a* 444 44 4,4 488 88 4,8 b* b (b* 413 4,1 951 9 51 9,51 037 37 0,3 099 99 0,9 mm humana (DMG 00 0,0 564 5 56,45 786 6 78,6 503 3 50,33 71 1 7,16 131 13,1 4,58 326 32,61 42 2 4,2 384 38,41 (L 553 55, 771 77,1 (a 4, 48 8 (b 95 9,5 03 0, 09 56,4 78, 50,3 7,1 13, 4,5 32,6 38,4 77, 9, 56, 50, 7, 32, 38,

Abstract Objective Eclampsia is a hypertensive disorder that occurs during pregnancy and can lead to death. The literature has gaps by not providing comprehensive data on the epidemiology of the disease, restricting analysis to limited temporal intervals and geographical locations. This study aims to characterize the epidemiological profile of women who died from eclampsia in Brazil from 2000 to 2021. Methods The maternal mortality data were obtained from the Sistema de Informações sobre Mortalidade, with the following variables of interest selected: “Federative Unit,” “Year,” “Age Range,” “Race/Color,” and “Education Level.” The collection of the number of live births for data normalization was conducted in the Sistema de Informações sobre Nascidos Vivos. Statistical analyses were performed using GraphPad Prism, calculating odds ratio for variables and fixing number of deaths per 100,000 live births for calculating maternal mortality ratio (MMR). Results There was a downward trend in maternal mortality rate during the study period. Maranhão stood out as the federative unit with the highest MMR (17 deaths per 100.000 live births). Mothers aged between 40 and 49 years (OR = 3.55, CI: 3.11–4.05) presents higher MMR. Additionally, black women showed the highest MMR (OR = 4.67, CI: 4.18–5.22), as well as mothers with no educational background (OR = 5.83, CI: 4.82–7.06). Conclusion The epidemiological profile studied is predominantly composed of mothers with little or no formal education, self-declared as Black, residing in needy states and with advanced aged. These data are useful for formulating public policies aimed at combating the issue. death disease locations 200 2021 Mortalidade selected Federative Unit, Unit Year, Year “Year, Age Range, Range Race/Color, RaceColor Race Color “Race/Color, Education Level. Level Vivos Prism 100000 100 000 100,00 . (MMR) period 17 (1 100.00 births. births) 4 OR 355 3 55 3.55 CI 3.11–4.05 311405 11 05 Additionally 467 67 4.67 4.18–5.22, 418522 4.18–5.22 , 18 5 22 4.18–5.22) 583 83 5.83 4.82–7.06. 482706 4.82–7.06 82 7 06 4.82–7.06) education selfdeclared self declared Black issue 20 202 “Year Race/Color “Race/Color 10000 10 00 100,0 (MMR 1 ( 100.0 35 3.5 3.11–4.0 31140 0 46 6 4.6 41852 4.18–5.2 2 58 8 5.8 48270 4.82–7.0 1000 100, 100. 3. 3.11–4. 3114 4. 4185 4.18–5. 5. 4827 4.82–7. 3.11–4 311 418 4.18–5 482 4.82–7 3.11– 31 41 4.18– 48 4.82– 3.11 4.18 4.82 3.1 4.1 4.8

ABSTRACT Objective: To present the methodology used in the development of two products for maternal health surveillance and its determinants and discuss their possible uses. Methods: Based on a theoretical model of the determinants of maternal death and databases of Brazilian health information systems, two free products were developed: an interactive panel “surveillance of maternal health” and an educational material “Aparecida: a story about the vulnerability of Brazilian women to maternal death”, both available on the website of the Brazilian Obstetric Observatory. Results: More than 30 indicators were calculated for the period 2012-2020, containing information on socioeconomic conditions and access to health services, reproductive planning, prenatal care, delivery care, conditions of birth and maternal mortality and morbidity. The indicators related to severe maternal morbidity in public hospitalizations stand out, calculated for the first time for the country. The panel allows analysis by municipality or aggregated by health region, state, macro-region and country; historical series analysis; and comparisons across locations and with benchmarks. Information quality data are presented and discussed in an integrated manner with the indicators. In the educational material, visualizations with national and international data are presented, aiming to help in the understanding of the determinants of maternal death and facilitate the interpretation of the indicators. Conclusion: It is expected that the two products have the potential to expand epidemiological surveillance of maternal health and its determinants, contributing to the formulation of health policies and actions that promote women’s health and reduce maternal mortality. Objective uses Methods systems developed Aparecida “Aparecida death, , death” Observatory Results 3 20122020, 20122020 2012 2020, 2020 2012-2020 services planning care out country region state macroregion macro benchmarks Conclusion womens s 2012202 201 202 2012-202 201220 20 2012-20 20122 2 2012-2 2012-

RESUME Objetivo: Apresentar a metodologia utilizada no desenvolvimento de dois produtos para a vigilância da saúde materna e seus determinantes e discutir as suas possíveis utilizações. Métodos: A partir de modelo teórico dos determinantes do óbito materno e bases de dados dos sistemas de informação em saúde brasileiros, foram desenvolvidos dois produtos gratuitos: um painel interativo denominado “Vigilância da saúde materna” e um material educativo chamado “Aparecida: uma história sobre a vulnerabilidade da mulher brasileira à morte materna”, ambos disponíveis no site do Observatório Obstétrico Brasileiro. Resultados: Foram calculados mais de 30 indicadores para o período 2012-2020, contendo informações sobre condições socioeconômicas e de acesso a serviços de saúde, planejamento reprodutivo, assistência pré-natal, assistência ao parto, condições de nascimento e mortalidade e morbidade materna. Destacam-se os indicadores relacionados à morbidade materna grave em internações públicas, calculados pela primeira vez para o país. O painel permite análises por município ou agregadas por região de saúde, unidade da federação, macrorregião e país; análises de série histórica; e comparações entre localidades e com padrões de referência. Dados de qualidade da informação são apresentados e discutidos de forma integrada aos indicadores. No material educativo, visualizações com dados nacionais e internacionais são apresentadas, visando auxiliar na compreensão dos determinantes do óbito materno e facilitar a interpretação dos indicadores. Conclusão: Espera-se que os produtos tenham o potencial de ampliar a vigilância epidemiológica da saúde materna e seus determinantes, contribuindo para a formulação de políticas e ações de saúde que promovam a saúde das mulheres e reduzam a mortalidade materna. Objetivo utilizações Métodos brasileiros gratuitos Vigilância Aparecida “Aparecida materna, , Brasileiro Resultados 3 20122020, 20122020 2012 2020, 2020 2012-2020 reprodutivo prénatal, prénatal pré natal, natal pré-natal parto Destacamse Destacam se públicas país federação histórica referência apresentadas Conclusão Esperase Espera 2012202 201 202 2012-202 201220 20 2012-20 20122 2 2012-2 2012-

ABSTRACT The aim of this study was to evaluate the effect of the drying adjuvants maltodextrin, gum Arabic and albumin on the physical and physicochemical characteristics of freeze-dried bacuri pulp powder. The adjuvants were added to the pulp at a concentration of 20% (w/w), giving three samples that were dehydrated in a freeze-dryer. The samples were analysed for moisture content, colour using the CIELab scale, phenolic compounds, hygroscopicity, particle morphology and density. The fluidity of the powders was evaluated using the Carr index and Hausner ratio. The moisture ranged from 2.33% to 2.76%, the powder containing albumin having the lowest moisture content (p < 0.05). A difference (p < 0.05) was seen in the colour parameters of the samples, except for luminosity in the samples containing maltodextrin or albumin. The level of phenolic compounds ranged from 183.22 to 386.90 mg GAE/100 g of solids, with the sample containing albumin again showing the lowest value (p < 0.05). The hygroscopicity of the powders ranged from 6.22% to 6.92%, the densities ranged from 287.9 to 433.1 kg/m3, and the wall friction angle from 12.2° to 13.55°. The Carr index and Hausner ratio varied from 23.21% to 25.80% and 1.30 to 1.34, respectively. The bacuri pulp powder was classified as having acceptable fluidity regardless of the adjuvant; however, the adjuvants had an effect on particle morphology and on the composition of the powder. freezedried freeze dried 20 w/w, ww w/w , w (w/w) freezedryer. freezedryer dryer. dryer freeze-dryer scale density 233 2 33 2.33 276 76 2.76% p 0.05. 005 0.05 . 0 05 18322 183 22 183.2 38690 386 90 386.9 GAE100 GAE 100 GAE/10 solids 622 6 6.22 692 92 6.92% 2879 287 9 287. 4331 433 1 433. kgm3 kgm kg m3 m kg/m3 122 12 12.2 1355 13 55 13.55° 2321 23 21 23.21 2580 25 80 25.80 130 30 1.3 134 34 1.34 respectively adjuvant however (w/w 3 2.3 27 7 2.76 00 0.0 1832 18 183. 3869 38 386. GAE10 10 GAE/1 62 6.2 69 6.92 28 43 kg/m 12. 135 5 13.55 232 23.2 258 8 25.8 1. 2. 2.7 0. GAE1 GAE/ 6. 6.9 4 13.5 23. 25. 13.

Abstract Objective: To describe the accuracy of HealthVCF, a software product that uses artificial intelligence, in the detection of incidental moderate-to-severe vertebral compression fractures (VCFs) on chest and abdominal computed tomography scans. Materials and Methods: We included a consecutive sample of 899 chest and abdominal computed tomography scans of patients 51–99 years of age. Scans were retrospectively evaluated by the software and by two specialists in musculoskeletal imaging for the presence of VCFs with vertebral body height loss > 25%. We compared the software analysis with that of a general radiologist, using the evaluation of the two specialists as the reference. Results: The software showed a diagnostic accuracy of 89.6% (95% CI: 87.4–91.5%) for moderate-to-severe VCFs, with a sensitivity of 73.8%, a specificity of 92.7%, and a negative predictive value of 94.8%. Among the 145 positive scans detected by the software, the general radiologist failed to report the fractures in 62 (42.8%), and the algorithm detected additional fractures in 38 of those scans. Conclusion: The software has good accuracy for the detection of moderate-to-severe VCFs, with high specificity, and can increase the opportunistic detection rate of VCFs by radiologists who do not specialize in musculoskeletal imaging. Objective HealthVCF intelligence moderatetosevere moderate severe (VCFs Methods 89 5199 51 99 51–9 age 25 25% reference Results 896 6 89.6 95% 95 (95 CI 87.4–91.5% 874915 87 4 91 5 738 73 8 73.8% 927 92 7 92.7% 948 94 94.8% 14 42.8%, 428 42.8% , 42 (42.8%) 3 Conclusion 519 9 51– 2 89. (9 87.4–91.5 87491 73.8 92.7 94.8 1 42.8 (42.8% ( 87.4–91. 8749 73. 92. 94. 42. (42.8 87.4–91 874 (42. 87.4–9 (42 87.4– (4 87.4 87.

Resumo Objetivo: Descrever a acurácia do software HealthVCF na detecção incidental de fraturas compressivas de corpos vertebrais moderadas a graves em exames de tomografia computadorizada do tórax e abdome. Materiais e Métodos: Foram incluídos 899 exames consecutivos de pacientes com idades entre 51 e 99 anos. As imagens foram retrospectivamente avaliadas pelo software e por dois radiologistas especializados em musculoesquelético que investigaram fraturas compressivas de corpos vertebrais com perda da altura somática > 25%. A análise comparativa foi realizada entre o software e um radiologista geral, usando a avaliação do especialista como referência. Resultados: O software apresentou uma acurácia de 89,6% (IC 95%: 87,4–91,5%) para fraturas compressivas moderadas a graves, com sensibilidade de 73,8%, especificidade de 92,7% e valor preditivo negativo de 94,8%. Entre as 145 tomografias positivas detectadas pelo software, o radiologista geral deixou de relatar as fraturas em 62 (42,8%) e o algoritmo detectou fraturas adicionais em 38 dessas tomografias. Conclusão: O software possui boa acurácia na detecção de fraturas compressivas moderadas a graves, com alta especificidade, podendo aumentar a taxa de detecção oportunística dessas fraturas por radiologistas não especializados em musculoesquelético. Objetivo abdome Métodos 89 5 9 anos 25 25% referência Resultados 896 6 89,6 IC 95% 95 87,4–91,5% 874915 87 4 91 738 73 8 73,8% 927 92 7 92,7 948 94 94,8% 14 42,8% 428 42 (42,8% 3 Conclusão 2 89, 87,4–91,5 87491 73,8 92, 94,8 1 42,8 (42,8 87,4–91, 8749 73, 94, 42, (42, 87,4–91 874 (42 87,4–9 (4 87,4– ( 87,4 87,

Abstract Social constructivism can be taken as a broad sociological-philosophical approach of science which is introduced as follows: i) an explanation of the acceptance of successful scientific achievements ought to be done through the use of epistemological criteria and social community factors; ii) the knowledge produced by successful scientific achievements cannot be taken as a representation of reality. The social constructivist approach has always been strongly criticized by traditional philosophical conceptions of science because 1) an explanation of the success of successful scientific theories should be made only through the use of epistemological criteria, and 2) the knowledge produced by successful scientific achievements matchs to reality. This paper deals with the first criticism, by means of an expanded analysis of the debate between a representative of social constructivism (David Bloor) and a critic (Larry Laudan), based on the hypothesis that, although Laudan has pointed out some important limits to the scope of the social constructivist approach, the argumentative core of his critique does not hold itself, except as a prescription about the tasks that a philosopher of science must do. sociologicalphilosophical sociological follows i factors ii reality 1 2 criticism David Bloor Larry Laudan, , Laudan) itself do

Resumo O socioconstrutivismo é uma ampla concepção sociológico-filosófica da ciência que pode ser assim apresentado: i) uma explicação da aceitação de realizações científicas bem-sucedidas deve ser feita por meio do emprego de critérios epistemológicos e de fatores sociocomunitários; ii) o conhecimento produzido pelas realizações científicas bem-sucedidas não é uma representação da realidade. A concepção socioconstrutivista sempre foi fortemente criticada pelas concepções filosóficas tradicional de ciência pois 1) uma explicação do sucesso das teorias científicas bem-sucedidas deve ser feita por meio apenas do emprego de critérios epistemológicos; e 2) o conhecimento produzido pelas realizações científicas bem-sucedidas, para ser considerado efetivamente um conhecimento, deve ser uma representação da realidade. Este artigo trata da primeira crítica, por meio de uma análise ampliada do debate entre um representante do socioconstrutivismo (David Bloor) e um crítico (Larry Laudan) a partir da hipótese de que, embora Laudan tenha apontado alguns limites importantes do alcance da concepção socioconstrutivista, o núcleo argumentativo de sua crítica não se sustenta, exceto como uma prescrição sobre as tarefas que devem ser realizadas por um filósofo da ciência. sociológicofilosófica sociológico filosófica apresentado i bemsucedidas bem sucedidas sociocomunitários ii realidade 1 2 bemsucedidas, sucedidas, David Bloor Larry sustenta

ABSTRACT The use of corn hybrids adapted to the soil and climate conditions of the cultivation region under adequate optimum plant density is a determining factor for the maximization of grain yield. In this sense, the objective was to evaluate the productivity of corn hybrids under two sowing densities during the 2020/21 crop season in the medium-high Uruguay region of the state of Rio Grande do Sul. The corn hybrids AS1555 PRO3, B2401 PWU, B2418 VYHR, B2612 PWU, BG7061 YHR, DKB235 PRO3, NS45 VIP3, NS73 VIP3, NS80 VIP3, P2501, P3016 VYHR, P3565 PWU and 30F53 VYHR were submitted to densities of 66,667 and 88,889 plants ha-1, in a randomized block design with ten replications. Corn hybrids showed superior grain yield when subjected to the density of 88,889 plants ha-1 in the medium-high Uruguay region of Rio Grande do Sul, surpassing in most cases the state and national average yield of harvest 2020/21. Most of the corn hybrids used present potential for cultivation at higher sowing density than their respective recommendations. Considering the superior productivity of hybrids NS80 VIP3, B2401 PWU and NS73 VIP3, their cultivation under conditions similar to those of the study is recommended. sense 202021 2020 21 2020/2 mediumhigh medium high Sul AS AS155 PRO3 PRO B B240 B241 B261 BG BG706 YHR DKB DKB23 NS NS4 VIP3 VIP NS7 NS8 P2501 P P301 P356 F 30F5 66667 66 667 66,66 88889 88 889 88,88 ha1, ha1 ha 1, 1 replications ha- recommendations recommended 20202 202 2 2020/ AS15 B24 B26 BG70 DKB2 P250 P30 P35 30F 6666 6 66,6 8888 8 88,8 20 AS1 B2 BG7 P25 P3 666 66, 888 88, P2