RESUMO: O estudo de adaptabilidade, estabilidade e produtividade é importante para selecionar e recomendar genótipos superiores. Esse fato é particularmente válido para a introdução de cultivares de feijão comum no Rio de Janeiro, Brasil, cuja produção é ínfima e não atende a demanda interna. Assim, este trabalho teve como objetivo estimar parâmetros genéticos e ganhos de seleção e realizar uma seleção simultânea para adaptabilidade, estabilidade e produtividade de genótipos de feijão preto através de modelos mistos. O estudo foi realizado em três municípios do estado do Rio de Janeiro e em três anos agrícolas. Os ensaios foram instalados em delineamento de blocos casualizados com 11 genótipos e três repetições. Observou-se alta herdabilidade média (81%), acurácia seletiva (90%) e boas perspectivas de seleção. Também foram observados ganhos satisfatórios para a característica entre 1,03 e 9,49%. A seleção simultânea foi eficiente e permitiu selecionar duas linhagens de feijão preto CNFP (15290 e 15361) como sendo as mais produtivas, adaptáveis e estáveis e, portanto, têm potencial para serem lançadas como novas cultivares de feijão preto para o estado do Rio de Janeiro. RESUMO adaptabilidade superiores Brasil interna Assim mistos agrícolas 1 repetições Observouse Observou se 81%, 81 81% , (81%) 90% 90 (90% 103 03 1,0 949 9 49 9,49% 15290 (1529 15361 produtivas portanto 8 (81% (90 10 0 1, 94 4 9,49 1529 (152 1536 (81 (9 9,4 152 (15 153 (8 ( 9, 15 (1

ABSTRACT: The study of adaptability, stability, and productivity is essential for selecting and recommending superior genotypes. This fact is particularly the case for the introduction of common bean cultivars in Rio de Janeiro, Brazil, whose production is negligible and does not meet the internal demand. Thus, this study estimated genetic parameters and selection gains and undertake a simultaneous selection for adaptability, stability, and productivity in black bean genotypes via mixed models. The investigation was carried out in three municipalities in the state of Rio de Janeiro during three crop years. The trials were set up in a randomized block design with 11 genotypes and three replications. High mean heritability (81%) and selection accuracy (90%), as well as good selection prospects, were observed. Gains between 1.03 and 9.49% were achieved for grain yield. Simultaneous selection was efficient, indicating two black bean lines (CNFP 15290 and CNFP 15361) as the most productive, adaptable, and stable. As such, these lines have the potential to be released as new black bean cultivars for the state of Rio de Janeiro. ABSTRACT adaptability stability Brazil demand Thus models years 1 replications 81% 81 (81% 90%, 90 90% , (90%) prospects observed 103 03 1.0 949 9 49 9.49 yield efficient 1529 15361 productive adaptable stable such 8 (81 (90% 10 0 1. 94 4 9.4 152 1536 (8 (90 9. 15 153 ( (9

Abstract Objectives To investigate the associations between caregivers’ burden, family quality of life (QoL), and siblings’ QoL in Brazilian families of children with cerebral palsy, and to analyze siblings’ QoL using as a parameter the QoL of typically developed Brazilian children. Methods It was a cross-sectional study. The 212 families, 212 caregivers and 131 siblings completed the Family Quality of Life Scale, Burden Interview, and KIDSCREEN-27 Child and Adolescent Version and Parents Version questionnaires at a neurorehabilitation center in southeast Brazil. Univariable and multivariable models were used. Results Family QoL significantly worsened as caregivers’ burden increased (95 % CI -0.66 to -0.38). Caregivers’ burden was significantly lower with increasing family QoL scores (95 % CI -0.52 to -0.30). Self-reported siblings’ QoL was significantly worse than that of their typically developed peers (95 % CI -7.6 to -3.6). Self-reported siblings’ QoL was significantly lower as siblings’ age (95 % CI -2.52 to -0.59) and caregivers’ burden (95 % CI -0.35 to -0.05) increased. Parent-reported siblings’ QoL was significantly lower with increasing caregivers’ burden (95 % CI -0.45 to -0.16) and higher as family QoL increased (95 % CI 0.09 to 0.37). Conclusions The cross-sectional nature of these data precludes any statement of causality. Family QoL worsened with higher caregivers’ burden levels. Lower caregivers’ burden scores were associated with a higher family QoL. Siblings’ QoL was impaired as compared to typically developed peers, worse among older siblings, and as caregivers’ burden increased and better with higher family QoL levels. Future multicenter studies may validate the generalizability of the present findings. QoL, , (QoL) palsy crosssectional cross sectional study 21 13 Scale Interview KIDSCREEN27 KIDSCREEN 27 KIDSCREEN-2 Brazil used 95 (9 0.66 066 0 66 -0.6 0.38. 038 0.38 . 38 -0.38) Caregivers 0.52 052 52 -0.5 0.30. 030 0.30 30 -0.30) Selfreported Self reported 7.6 76 7 6 -7. 3.6. 36 3.6 3 -3.6) 2.52 252 2 -2.5 0.59 059 59 -0.59 0.35 035 35 -0.3 0.05 005 05 -0.05 Parentreported Parent 0.45 045 45 -0.4 0.16 016 16 -0.16 009 09 0.0 0.37. 037 0.37 37 0.37) causality levels Siblings findings (QoL 1 KIDSCREEN2 KIDSCREEN- 9 ( 0.6 06 -0. 03 0.3 -0.38 0.5 5 -0.30 7. -7 3. -3.6 2.5 25 -2. 00 -0.0 0.4 04 4 0.1 01 -0.1 0. -0 - -3. 2. -2 -3

ABSTRACT In-depth knowledge of total soil organic phosphorus (TPO) as a potential P source for plants allows for a comprehensive understanding of the adoption of an efficient management system of phosphorus fertilization in forest plantations. Thus, we aimed to compare three TPO extraction methods (Hedley; Bowman; Bowman and Moir) in different Eucalyptus plantations on strongly weathered soils. The TPO concentrations obtained by the “Hedley” (mean of 130 mg kg–1), and “Bowman and Moir” methods (mean of 131 mg kg–1) were similar. The “Bowman” method extracted less than 50 % of the TPO content extracted by the other methods. Both “Hedley” and “Bowman and Moir” methods showed similar TPO extraction efficiency compared to TP determined by acid digestion. However, the “Hedley” method is the most expensive and time-consuming analytical technique. In view of this, the NaOH+Na2EDTA extractor (Bowman and Moir) would be the most suitable since, in addition to showing high extraction efficiency, it offers fast analysis execution, low analytical error, and lower cost. Indepth depth (TPO Thus Hedley (Hedley Moir soils “Hedley mean 13 kg–1, kg1 kg kg–1 , 1 5 digestion However timeconsuming time consuming technique this NaOHNa2EDTA NaOHNaEDTA NaOH Na2EDTA Na EDTA since execution error cost kg– NaOHNa NaEDTA

ABSTRACT Shade-tolerant soybean genotypes will allow their greater adoption for use in agroforestry or intercropped systems in tropical and subtropical regions. These genotypes can be obtained from the selection of existing superior genotypes or through breeding programs. This study, was verified such genetic variability and select those genotypes with cultivation potential at reduced levels of photosynthetically active radiation (PAR). Morphophysiological and yield characteristics of 16 soybean genotypes were evaluated in two experiments conducted in a controlled environment and laid in a randomized block design with three replications. Genetic parameters, correlations and genetic diversity were estimated and path analysis was performed. The soybean cultivars used showed genetic variability with a high variation index and heritability, which is advantageous for the selection of superior cultivars. Leaf area showed genotypic correlation and had a direct effect on seed weight per plant, regardless of shading. Additionally, the number of pods, hypocotyl diameter, and leaf area, all indirectly contributed to seed weight per plant regardless of shading. Seven genotypes (NS7780, NS8338, NS7667, NS7901, RK8115, CZ37B43 and 8579RSF) were selected based on genetic gain obtained by the Mulamba and Mock index at the two levels of PAR reduction tested. Furthermore, five of these genotypes (CZ37B43, RK8115, NS7901, NS8338 and 8579RSF) were identified by the Unweighted Pair-Group method Arithmetic Mean, as suitable either as a shaded crop or, as parental materials in breeding programs. Shadetolerant Shade tolerant regions programs study PAR. . (PAR) 1 replications parameters performed heritability shading Additionally pods diameter NS7780, NS7780 NS (NS7780 NS7667 NS7901 RK8115 RK CZB CZ B CZ37B4 8579RSF RSF tested Furthermore CZ37B43, (CZ37B43 NS833 PairGroup Pair Group Mean (PAR NS778 (NS778 NS766 NS790 RK811 CZ37B (CZ37B4 NS83 NS77 (NS77 NS76 NS79 RK81 (CZ37B NS8 NS7 (NS7 RK8 (NS

ABSTRACT BACKGROUND: Stroke is a major cause of mortality worldwide. Renal dysfunction is an important risk factor for stroke. Brazilian studies on stroke knowledge are generally population based. Studies stratifying stroke knowledge according to comorbidities are rare. Scientific data are essential to guide the awareness of stroke. OBJECTIVE: To assess stroke knowledge in patients with chronic kidney disease (CKD) on hemodialysis. DESIGN AND SETTING: Cross-sectional analytical study of patients with CKD on hemodialysis in north-eastern Brazil. METHODS: A self-administered questionnaire survey on stroke awareness was administered to patients with CKD on hemodialysis between April and November 2022. The chi-square test and other descriptive statistics were used. Univariate and multivariate analyses were performed using logistic regression. RESULTS: A total of 197 patients were included in the analysis. The Brazilian acronym for stroke was used by 53.5% of the participants. Less than 10.0% of the sample showed optimal decision-making ability regarding stroke. Of the participants, 29.9% knew at least one risk factor and one symptom; however, this was considered as having below the minimum capacity because they did not know the emergency service call number. In the analysis adjusted for income and education, females (odds ratio [OR], 0.40%; 95% confidence interval [CI], 0.20-0.82), older patients (OR, 0.24%; 95% CI, 0.09-0.63) and having at most one comorbidity (OR, 0.48%; 95% CI, 0.23-0.98) were factors for lower levels of knowledge or ideal decision-making capacity against stroke. CONCLUSIONS: Patients on hemodialysis, especially women and older people, have little knowledge about stroke. BACKGROUND worldwide based rare OBJECTIVE (CKD SETTING Crosssectional Cross sectional northeastern north eastern Brazil METHODS selfadministered self 2022 chisquare chi square regression RESULTS 19 535 53 5 53.5 participants 100 10 0 10.0 decisionmaking decision making 299 29 9 29.9 symptom however number education odds OR, OR , [OR] 0.40% 040 40 95 CI [CI] 0.200.82, 020082 0.20 0.82 20 82 0.20-0.82) (OR 0.24% 024 24 0.090.63 009063 0.09 0.63 09 63 0.09-0.63 0.48% 048 48 0.230.98 023098 0.23 0.98 23 98 0.23-0.98 CONCLUSIONS people 202 1 53. 10. 2 29. [OR 0.40 04 4 [CI 200 0.200.82 02008 020 0.2 082 0.8 8 0.20-0.82 0.24 02 090 0.090.6 00906 009 0.0 063 0.6 6 0.09-0.6 0.48 230 0.230.9 02309 023 098 0.9 0.23-0.9 0.4 0.200.8 0200 0. 08 0.20-0.8 0.090. 0090 00 06 0.09-0. 0.230. 0230 0.23-0. 0.200. 0.20-0. 0.090 0.09-0 0.230 0.23-0 0.200 0.20-0 0.09- 0.23- 0.20-

ABSTRACT Root-knot nematodes cause a significant reduction in the productivity of the gilo due to physiological stress. Incorporating organic residue into the soil has a positive effect in reducing nematode infestation. The aim of this study was to evaluate the effect of the addition of organic residue on the reproduction of Meloidogyne javanica and its role in the physiology of the gilo. One-litre pots, each containing one gilo seedling, were inoculated with 5000 eggs of M. javanica and the following treatments evaluated: 1) no inoculation and no residue (NIR); 2) NIR; 3) 12.5 g L-1 poultry manure; 4) 25 g L-1 cattle manure; 5) 20 g L-1 filter cake; 6) 5 g L-1 of the shoots of Tagetes patula; 7) 6.25 g L-1 of the shoots of Brassica oleracea var. capitata; 8) 20 mL L-1 vinasse and 9) 1 mL Abamectin-based commercial product (18 g L-1 a.i.). A randomised block design was used, with six repetitions. Gas exchange variables were evaluated 15, 30 and 45 days after inoculation with the nematode (DAI) and the vegetative and nematological variables at 60 DAI. The treatments that included cattle manure and filter cake afforded the best physiological rate and development in the gilo. The best results in controlling the nematode were given by the poultry manure, cattle manure and filter cake, reducing the reproduction of M. javanica by 41.76, 51.44 and 52.40%, respectively. Based on the results, poultry manure, cattle manure and filter cake are efficient in controlling M. javanica and show potential to be used in the integrated management of M. javanica in the gilo. Rootknot Root knot stress infestation Onelitre One litre pots seedling 500 M NIR (NIR) 2 3 125 12 12. L1 L L- 4 6 patula 7 625 6.2 var capitata 8 9 Abamectinbased Abamectin based 18 (1 a.i.. ai a.i. . i a.i.) repetitions 15 DAI (DAI 4176 41 76 41.76 5144 51 44 51.4 5240 52 40 52.40% respectively 50 (NIR 62 6. ( a.i 417 41.7 514 51. 524 52.40 41. 52.4 52.

Résumé L’objectif de cet article est d’analyser la stratification horizontale de l’enseignement supérieur au Brésil en mettant l’accent sur les cours d’Ingénierie, de Médecine et de Droit. Il s’agit de rechercher si ces territoires diffèrent selon le profil socio-économique de leurs diplômés et s’il y a eu des changements dans ce profil dans une période d’expansion rapide du système éducatif. Les résultats obtenus à l’aide de modèles multinomiaux et de régression logistique indiquent que ces cours présentent différents schémas d’inégalité selon la race, le sexe et l’éducation des parents. Le travail a identifié une diminution des inégalités pour la période analysée, mais avec des particularités importantes entre les zones et entre les types institutionnels. Les analyses renforcent les hypothèses selon lesquelles la stratification horizontale peut être un mécanisme de maintien des inégalités en période d’expansion des systèmes éducatifs et qu’elle devrait varier selon les groupes professionnels. Lobjectif L objectif danalyser d analyser lenseignement l enseignement laccent accent dIngénierie, dIngénierie Ingénierie, Ingénierie d’Ingénierie Droit sagit s agit socioéconomique socio économique sil il dexpansion expansion éducatif laide aide dinégalité inégalité race léducation éducation parents analysée institutionnels quelle qu elle professionnels

Resumen El objetivo del artículo es analizar la estratificación horizontal de la educación superior en Brasil con énfasis en los cursos de ingeniería, medicina y derecho. Se pretende investigar si esas áreas se diferencian de acuerdo con el perfil socioeconómico de sus egresados y si hubo transformaciones en ese perfil en un periodo de rápida expansión del sistema de enseñanza. Los resultados obtenidos a través de modelos multinomiales y de regresión logística indican que esos cursos presentan diferentes patrones de desigualdad de acuerdo con raza, sexo y escolaridad de los padres. Este trabajo identificó una disminución en las desigualdades para el período analizado, pero con particularidades importantes entre las áreas y los tipos institucionales. Los análisis refuerzan las hipótesis de que la estratificación horizontal puede ser un mecanismo de mantenimiento de las desigualdades en periodos de expansión de los sistemas de enseñanza y que varían de acuerdo con el grupo profesional. ingeniería derecho raza padres analizado institucionales profesional

Resumo O objetivo do artigo é analisar a estratificação horizontal do ensino superior no Brasil com enfoque nos cursos de engenharia, medicina e direito. Pretende-se investigar se essas áreas se diferenciam de acordo com o perfil socioeconômico de seus concluintes e se houve transformações nesse perfil em um período de rápida expansão do sistema de ensino. Resultados obtidos através de modelos multinomiais e de regressão logística indicam que esses cursos apresentam diferentes padrões de desigualdade de acordo com raça, sexo e escolaridade dos pais. O trabalho identificou uma diminuição nas desigualdades para o período analisado, mas com particularidades importantes entre as áreas e entre os tipos institucionais. As análises reforçam as hipóteses de que a estratificação horizontal pode ser um mecanismo de manutenção das desigualdades em períodos de expansão dos sistemas de ensino e que deve variar de acordo com o grupo profissional. engenharia direito Pretendese Pretende raça pais analisado institucionais profissional

Abstract This paper analyzes the horizontal stratification of higher education in Brazil, focusing on engineering, medicine, and law majors. It intends to investigate whether these fields of study differ according to the socioeconomic profile of their graduates and whether these profiles have changed in light of a recent and rapid expansion of the education system. Results from multinomial models and logistic regression indicate that these fields present different patterns of inequality according to race, gender, and parents’ education. Inequalities by institutional sector and the dynamics between years were also different in each field. The study found a drop in inequalities within the period analyzed, but with important specificities. The results reinforce the hypothesis that horizontal stratification may be a mechanism to maintain inequalities in periods of expansion of education systems and that it should vary according to the professional group. Brazil engineering medicine majors system race gender parents field analyzed specificities group

ABSTRACT The Brazilian Health Ministry launched in 2019 a new financing policy for Primary Health Care, Previne Brasil Program, which has required municipalities to adapt. The research aim is to analyze the implementation of the Previne Brasil Program in a southern region county. Characterized as an analysis of public policies, the methodology included interviews and document analysis. The results were organized into six sub-themes: municipal law and the Program’s evaluation and monitoring commission; bonus system; changes in work processes; main difficulties; social participation; and future expectations for Primary Health Care. During the implementation of the Previne Brasil Program, significant changes can be observed in the work processes, stimulated by the goals and indicators established, and also by the transfer of resources to professionals through individual bonuses. By adopting a managerial perspective, the changes in the financing of Primary Health Care point to the detachment in relation to the Unified Health System principles and guidelines, such as universality, integrality and social participation. The Program’s implementation at municipal level can lead to the focusing of health actions, relativization of the local analysis of health situation and centralization of the planning processes.

RESUMO Em 2019, o Ministério da Saúde lançou uma nova política de financiamento da Atenção Básica, o Programa Previne Brasil, que tem exigido a adaptação pelos municípios. O objetivo do presente estudo é analisar a implementação do Programa Previne Brasil em um município do Sul do País. A metodologia caracteriza-se como análise de políticas públicas, por meio de entrevistas e análise documental. Os resultados foram organizados em seis subtemas: lei municipal e comissão de avaliação e monitoramento do Programa; sistema de gratificações; mudanças no processo de trabalho; principais dificuldades enfrentadas; participação social; e expectativas futuras para a Atenção Básica. No processo de implementação do Programa Previne Brasil, observam-se mudanças significativas no trabalho das equipes, estimuladas pelo estabelecimento de metas e indicadores, e pelo repasse dos recursos aos profissionais na forma de gratificações individuais. Ao adotarem uma perspectiva gerencialista, as mudanças no financiamento da Atenção Básica apontam para o distanciamento em relação aos princípios e diretrizes do Sistema Único de Saúde como universalidade, integralidade e participação da comunidade. A implementação do programa em âmbito municipal pode induzir à focalização de ações em saúde, à relativização da análise local da situação de saúde e à centralização do processo de planejamento.

ABSTRACT The COVID-19-19 pandemic's global impact has accelerated the need for effective vaccines, challenging traditional, time-consuming, and costly vaccinology methods. Immunoinformatics emerges as a promising alternative to expedite vaccine development, thus this study aims to provide a comprehensive bibliometric analysis of its application in formulating SARS-CoV-2 vaccine prototypes. Employing VOSviewer software and data from the Web of Science database, this study conducted a bibliometric analysis. Key metrics included the global distribution of scientific publications, the most productive countries and institutions, influential authors, co-citation and co-authorship networks, and prevalent keywords in immunoinformatics research related to SARS-CoV-2 vaccines. The analysis encompassed 138 scholarly articles, with India emerging as a pivotal contributor, particularly through notable contributions from Adamas and Fakir Mohan universities. The most cited article, authored by Bhattacharya, received 226 citations, while Doytchinova was a prominent cited source, referenced in 96 of the 138 analyzed documents. The study observed substantial collaborative efforts among authors from 45 nations, with 85% of the research concentrated in just six countries. Pakistan demonstrated the highest level of international collaboration, contributing to 15/20 collaborative publications. Keywords such as 'SARS-CoV-2', 'immunoinformatics', and 'prediction' were frequently encountered across most of these documents. This bibliometric analysis elucidates the primary research trends in the field and delineates the global scope and distribution of immunoinformatics studies in the realm of SARS-CoV-2 vaccine development. These findings offer a vital overview of the current landscape, guiding future research directions and potential collaborative efforts in the pursuit of effective COVID-19 vaccines.

RESUMEN El impacto global de la pandemia de COVID-19 ha acelerado la necesidad de vacunas efectivas, lo que ha desafiado los métodos tradicionales de vacunología que son costosos y consumen mucho tiempo. La inmunoinformática surge como una alternativa prometedora para acelerar el desarrollo de vacunas. Este estudio tuvo como objetivo proporcionar un análisis bibliométrico exhaustivo de su aplicación en la formulación de prototipos de vacunas contra el SARS-CoV-2. Utilizando el software VOSviewer y datos de la base de datos Web of Science, se realizó un análisis bibliométrico. Las métricas clave incluyeron: la distribución global de publicaciones científicas, los países e instituciones más productivos, autores influyentes, redes de cocitación y coautoría y palabras clave prevalentes en la investigación de inmunoinformática relacionada con las vacunas contra el SARS-CoV-2. El análisis abarcó 138 artículos académicos; la India emergió como un contribuyente principal, particularmente a través de contribuciones notables de las universidades Adamas y Fakir Mohan. El artículo más citado fue el de Bhattacharya, que recibió 226 citas; mientras que Doytchinova fue una fuente citada prominente, referenciada en 96 de los 138 documentos analizados. El estudio observó esfuerzos colaborativos sustanciales entre autores de 45 naciones con el 85 % de la investigación concentrada en seis países. Pakistán demostró el nivel más alto de colaboración internacional, al contribuir con 15 de los 20 artículos colaborativos. Palabras clave como 'SARS-CoV-2', 'immunoinformatics' y 'prediction' se encontraron frecuentemente en la mayoría de estos documentos. Este análisis bibliométrico aclara las principales tendencias de investigación en el campo y delinea el alcance global y la distribución de los estudios de inmunoinformática en el ámbito del desarrollo de vacunas contra el SARS-CoV-2. Los hallazgos ofrecen una visión vital del panorama actual, guían investigaciones futuras y posibles esfuerzos colaborativos en la búsqueda de vacunas efectivas contra la COVID-19.

La Atención Primaria de la Salud (APS) se considera la puerta de entrada preferencial para el cuidado en el sistema de salud, destinándose los servicios de emergencia para situaciones que exigen atención inmediata. El objetivo de este artículo fue intentar identificar motivaciones para el uso de servicios de urgencias por problemas de salud no urgentes en usuarios de este servicio. Estudio cualitativo con base en 29 entrevistas semiestructuradas realizadas en 2019 con usuarios de un servicio de urgencias del municipio de Vitória-ES. Los entrevistados perciben los servicios de urgencias y emergencias como aquellos en los que obtendrán cuidados inmediatos con mayor facilidad y resolución, puesto que el acceso a la APS de una forma inmediata, rápida y con resolución se presenta difícil. La utilización de urgencias por motivos no urgentes se mostró compleja y envuelve no solo la dificultad de acceso a la APS, sino la propia comprensión individual y colectiva del papel de cada equipo del sistema.

Primary health care is the point of entry to the health system, providing emergency services for situations that require immediate treatment. The aim of this study was to identify the reasons patients use emergency services for non-urgent medical problems. We carried out a qualitative study based on 29 semi-structured interviews with patients of an urgent care center in Vitória, Brazil, conducted in 2019. According to the interviewees, it was easier to get immediate resolutive care in urgent and emergency care services, while obtaining immediate, rapid access to resolutive care in primary care services was difficult. The findings show that the utilization or urgent care centers for non-urgent problems was complex and involved not only difficulty accessing primary care services, but also individual and public understanding of the role of each type of health facility in the health system.

A Atenção Primária à Saúde (APS) é considerada a porta de entrada preferencial para o cuidado no sistema de saúde; já os serviços de emergência são destinados para situações que exigem atendimento imediato. Este artigo buscou identificar motivações para o uso de pronto atendimentos por problemas de saúde não urgentes em usuários deste serviço. Trata-se de um estudo qualitativo baseado em 29 entrevistas semiestruturadas realizadas em 2019 com usuários de um pronto atendimento do município de Vitória, ES. Os entrevistados percebem os serviços de urgência e emergência como aqueles nos quais obterão cuidados imediatos com maior facilidade e resolubilidade, já que acessar a APS de uma maneira imediata, rápida e resolutiva se apresentou difícil. A utilização de prontoatendimentos por motivos não urgentes mostrou-se complexa e envolve não apenas a dificuldade de acesso à APS, mas a própria compreensão individual e coletiva do papel de cada equipamento do sistema.

In this work, the molecular properties of the (E)-3-(4-nitrobenzylidene)-2-(4-methoxyphenyl)-2,3-dihydro-1-(phenylsulfonyl)-quinolin-4(1H)-one were studied, both in a solid and isolated state. The effect of changing the substituent groups –OCH3 and –Cl in the phenyl portion was verified, where the structural and electronic properties were compared. The density functional theory was employed using the hybrid exchange-correlation functional with long-range correction M06-2X, combined with the polarized and diffuse basis set 6-311++G(d,p), in the gas phase. The electronic structure was also analyzed by frontier molecular orbitals and molecular electrostatic potential maps, where information about its chemical reactivity was obtained. Also, the supramolecular arrangement was analyzed by Hirshfeld surface (HS), 2D fingerprint plots, and quantum theory of atoms in molecules (QTAIM). The natural bond orbitals (NBO) calculations were carried out to analyze the stability and hyperconjugation energy. Finally, molecular docking was carried out to investigate the affinities of the quinoline-chalcone with a bacterial protein (Agrobacterium pathogens) and an ecdysone receptor-potential pesticidal activity. The results encourage further in vitro and in vivo analyses of the two kinds of organisms investigated. work E34nitrobenzylidene24methoxyphenyl2,3dihydro1phenylsulfonylquinolin41Hone E34nitrobenzylidene24methoxyphenyl23dihydro1phenylsulfonylquinolin41Hone EnitrobenzylidenemethoxyphenyldihydrophenylsulfonylquinolinHone E 3 4 nitrobenzylidene 2 methoxyphenyl 2,3 dihydro 1 phenylsulfonyl quinolin 1H one H studied state OCH3 OCH –OCH Cl verified compared exchangecorrelation exchange correlation longrange long range M062X, M062X MX M06 2X, 2X M X M06-2X 6311++Gd,p, 6311Gdp Gdp 6 311++G d,p , 311 G d p 6-311++G(d,p) phase maps obtained Also HS, HS (HS) D plots QTAIM. QTAIM . (QTAIM) NBO (NBO energy Finally quinolinechalcone quinoline chalcone Agrobacterium pathogens receptorpotential receptor activity investigated E34nitrobenzylidene24methoxyphenyl2 3dihydro1phenylsulfonylquinolin41Hone phenylsulfonylquinolin Hone 23 2, M0 6311 Gd 6311++Gd,p 311G dp 31 6-311++G(d,p (HS (QTAIM Enitrobenzylidenemethoxyphenyl E34nitrobenzylidene24methoxyphenyl dihydrophenylsulfonylquinolinHone 631 63

Resumo Diante da plataformização de tantas formas de interação social, a antropologia digital tem lidado com novos desafios ético-metodológicos. Neste artigo, exploramos como o aprendizado e o uso de métodos mistos (quanti-quali) podem contribuir para o fazer antropológico no estudo de sistemas complexos como as plataformas digitais. Trazemos neste artigo um estudo de caso no qual demonstramos como pudemos observar as mensagens mais compartilhadas entre os usuários de mais de 200 grupos de extrema direita presentes no Telegram no dia 8 de janeiro de 2023. Baseados na experiência de testes e aplicações de novas metodologias multidisciplinares que relacionam as ciências da tecnologia da informação e a antropologia social, buscamos realizar análises amostrais do evento político ocorrido em Brasília. Assim, refletimos sobre as implicações éticas desses novos métodos e concluímos reforçando a importância do aprimoramento e a necessidade de revisões éticas que permitam o uso de métodos mistos no fazer da antropologia digital. social éticometodológicos. éticometodológicos ético metodológicos. metodológicos ético-metodológicos quantiquali quanti quali (quanti-quali digitais 20 2023 Brasília Assim 2 202

Abstract Given the platformization of so many forms of social interaction, digital anthropology faces new ethical and methodological challenges. In this article, we explore how learning and the use of mixed methods (quanti-quali) can contribute to anthropological work in the study of complex systems such as digital platforms. In this article, we present a case study of how we observed the most shared messages among users of more than 200 extreme far-right groups on Telegram on January 8, 2023. Based on the experience of testing and applying new multidisciplinary methods that combine computer science and social anthropology, we sought to conduct exemplary analyzes of the political event that took place in Brasilia. We reflect on the ethical implications of these new methods and conclude by emphasizing the importance of improvements and the need for ethical revisions enabling the use of mixed methods in digital anthropology. interaction challenges article quantiquali quanti quali (quanti-quali platforms 20 farright far right 8 2023 Brasilia 2 202

Abstract Postprandial lipemia (PPL) is associated with cardiovascular diseases, and it is assessed by the oral fat tolerance test (OFTT), which measures circulating triacylglycerol (TG). The objective is to propose an OFTT meal and to evaluate men’s and women’s perceptions, attitudes, sensory acceptability, and satiety. After overnight fasting, blood was collected (n=105), participants ingested the OFTT meal (75.4g lipids, 25.2g carbohydrates, and 10.8g protein/ 822.6 Kcal), and a new blood sample was collected 4h later. Fasting TG was 125.7±92.0 mg/dL (mean±SD) for men and 108.9±52.6 mg/dL for women. It increased by 97.7% and 86.7%, respectively, 4h after meal ingestion (P<0.0001), with no change in glucose. Participants felt satiated during the test. The meal was considered easy to eat and better tolerated by men. The median overall sensory acceptability was 7.0 [9-point hedonic scale]. The greatest fullness was seen in the first hour (magnitude satiety scale) and higher for women (P<0.01). The fatty meal proposed by the current study is adequate for the OFTT since it increased blood TG after 4h without hypoglycemia, it was easy to prepare, to eat, it kept participants satiated, and it displayed good perception, attitudes, and sensory acceptability. PPL (PPL diseases OFTT, , (OFTT) TG. . (TG) mens s womens perceptions attitudes fasting n=105, n105 n n=105 105 (n=105) 75.4g 754g g 75 4g lipids 252g 25 2g carbohydrates 108g 10 8g protein 8226 822 6 822. Kcal, Kcal Kcal) h later 1257920 125 7 92 0 125.7±92. mgdL mg dL mean±SD meanSD mean SD (mean±SD 1089526 108 9 52 108.9±52. 977 97 97.7 867 86 86.7% respectively P<0.0001, P00001 P P<0.0001 0001 (P<0.0001) glucose 70 7. 9point point scale. scale scale] magnitude P<0.01. P001 P<0.01 01 (P<0.01) hypoglycemia prepare perception (OFTT (TG n10 n=10 (n=105 2 1 82 125792 12 125.7±92 108952 5 108.9±52 97. 8 86.7 P0000 P<0.000 000 (P<0.0001 P00 P<0.0 (P<0.01 n1 n=1 (n=10 12579 125.7±9 10895 108.9±5 86. P000 P<0.00 00 (P<0.000 P0 P<0. (P<0.0 n= (n=1 1257 125.7± 1089 108.9± (P<0.00 P<0 (P<0. (n= 125.7 108.9 P< (P<0 (n 125. 108. (P< (P

RESUMO Objetivo desenvolver a etapa de validade baseada nos processos de resposta do Protocolo de Análise Espectrográfica da Voz (PAEV). Métodos foram recrutados dez fonoaudiólogos e dez alunos de graduação em Fonoaudiologia, que aplicaram o PAEV em dez espectrogramas, realizaram o julgamento dos itens do PAEV e participaram de uma entrevista cognitiva. A partir das respostas, o PAEV foi reanalisado para reformulação ou para exclusão de itens. Utilizou-se o teste Qui-Quadrado e os valores de acurácia para análise das respostas dos questionários, assim como análise qualitativa dos dados da entrevista cognitiva. Resultados os participantes obtiveram acurácia maior que 70% na maioria dos itens do PAE. Apenas sete itens alcançaram acurácia menor ou igual a 70%. Houve diferença entre as respostas de presença versus ausência de dificuldade na identificação dos itens no espectrograma. A maioria dos participantes não teve dificuldade na identificação dos itens do PAEV. Na entrevista cognitiva, apenas seis itens não obtiveram correta identificação da intenção, conforme verificado na análise qualitativa. Além disso, os participantes sugeriram exclusão de cinco itens. Conclusão após a etapa de validação baseada nos processos de resposta, o PAEV foi reformulado. Sete itens foram excluídos e dois itens foram reformulados. Dessa forma, a versão final do PAEV após essa etapa foi reduzida de 25 para 18 itens, distribuídos nos cinco domínios. . (PAEV) Fonoaudiologia espectrogramas cognitiva Utilizouse Utilizou se QuiQuadrado Qui Quadrado questionários 70 PAE espectrograma intenção disso reformulado reformulados forma 2 1 domínios (PAEV 7

ABSTRACT Purpose To develop the validity step based on the response processes of the Spectrographic Analysis Protocol (SAP). Methods 10 speech therapists and 10 undergraduate students of the Speech Therapy course were recruited, who applied the SAP in 10 spectrograms, performed the evaluation of the PAE items, and participated in a cognitive interview (CI). The SAP was reanalyzed to reformulate or exclude items based on the responses. The chi-square test and the accuracy values were used to analyze the answers to the questionnaires and qualitative analysis of the CI data. Results the participants achieved accuracy > 70% in most items of the SAP. Only seven items achieved accuracy ≤ 70%. There was a difference between presence vs. absence of difficulty in identifying items in the spectrogram. Most participants had no problem identifying the SAP items. In the CI, only six items did not correctly identify the intention, verified in the qualitative analysis. In addition, participants suggested excluding five items. Conclusion After the validation step based on the response processes, the SAP is reformulated. Seven items were deleted, and two items were reformulated. Thus, the final version of the SAP after this stage was reduced from 25 to 18 items, distributed in the five domains. . (SAP) 1 recruited spectrograms CI. (CI) responses chisquare chi square data 70 vs spectrogram intention addition reformulated deleted Thus 2 domains (SAP (CI 7