Abstract The NBR 7190-3 (ABNT, 2022) presents various methods to determine the wood's modulus of elasticity, allowing for the adoption of equivalence between the modulus of elasticity in compression (Ec0) and tension (Et0). However, it does not provide a way to estimate the modulus of elasticity in bending (EM0), and such estimates do not consider the variation in anatomical structures among species. Faced with this gap, it is necessary to evaluate whether these equations are valid for different species. This article evaluated the elastic properties of three species: Cumaru (Dipteryx odorata), Marupá (Simarouba amara Aubl., Simaroubaceae) and Roxinho (Peltogyne spp., Leguminosae). For this purpose, a non-destructive flexural test was initially conducted, followed by compression and tension tests. Microscopic images were compared to understand the influence of anatomical structures on stiffness properties. The results confirmed the equivalence between Ec0 and Et0. The higher concentration of parenchyma cells in Cumaru and Roxinho is responsible for statistically lower values of EM0 compared to Ec0 and Et0. 71903 7190 3 7190- ABNT, ABNT (ABNT 2022 woods wood s Ec (Ec0 Et0 Et . (Et0) However EM0, EM , (EM0) species gap Dipteryx odorata, odorata odorata) Simarouba Aubl Aubl. Simaroubaceae Peltogyne spp spp. Leguminosae. Leguminosae Leguminosae) purpose nondestructive non destructive conducted tests 719 202 (Ec (Et0 (EM0 71 20 (Et (EM 7 2

Resumo A NBR 7190-3 (ABNT, 2022) apresenta diferentes métodos para determinar o módulo de elasticidade da madeira, permitindo a adoção de equivalência entre o módulo de elasticidade na compressão (Ec0) e na tração (Et0). Por outro lado, não apresenta uma forma de estimar o módulo de elasticidade na flexão (EM0), e tais estimativas não consideram a variação das estruturas anatômicas das espécies. Diante dessa lacuna, é necessário avaliar se essas equações são válidas para diferentes espécies. O presente artigo avaliou as propriedades elásticas de três espécies: Cumaru (Dipteryxodorata), Marupá (Simarouba amara Aubl., Simaroubaceae) e Roxinho (Peltogyne spp., Leguminosa). Para isso, realizou-se o ensaio não destrutivo de flexão, seguido de ensaios à compressão e à tração. Imagens microscópicas foram comparadas, para compreender a influência das estruturas anatômicas nas propriedades de rigidez. Os resultados confirmaram a equivalência entre Ec0 e Et0. A maior concentração de parênquimas no Cumaru e no Roxinho é responsável pelos valores estatisticamente inferiores de EM0 em relação ao Ec0 e Et0. 71903 7190 3 7190- ABNT, ABNT (ABNT 2022 madeira Ec (Ec0 Et0 Et . (Et0) lado EM0, EM , (EM0) espécies lacuna Dipteryxodorata, Dipteryxodorata (Dipteryxodorata) Simarouba Aubl Aubl. Simaroubaceae Peltogyne spp spp. Leguminosa. Leguminosa Leguminosa) isso realizouse realizou comparadas rigidez 719 202 (Ec (Et0 (EM0 (Dipteryxodorata 71 20 (Et (EM 7 2

Abstract Objective This study aimed to review literature from the past five years, focusing on the use of educational videos as a guidance tool for parents and guardians of children with lip and palate clefts. Source of data Conducted between April and July 2022, this integrative literature review was framed around the question: 'What is the evidence regarding the use of videos in health education for parents/guardians of children with cleft lip and palate? PICO strategy was used to develop the research. A literature search was undertaken across PubMed, Web of Science, Scopus, and the Virtual Health Library databases. Of the eight articles included in this review, four were sourced from the PubMed database, with three published in 2021. Summary of the findings The findings indicated that YouTube videos were moderately satisfactory and met the needs of parents or legal guardians to a partial extent. The majority of the videos analyzed in this review were characterized by a moderate level of informational content. One study particularly underscored that the content of these videos only partially satisfies the requirements of the parents or legal guardians of the children. Conclusions Nevertheless, such videos are considered viable alternatives for health education, offering numerous benefits yet facing challenges, primarily due to the scarcity of information on orofacial malformations. years clefts 2022 question What parentsguardians research Science Scopus databases database 2021 extent Nevertheless challenges malformations 202 20 2

RESUMO O objetivo deste artigo é contribuir para o debate sobre raça e etnia em meio às organizações de extrema-direita na internet, usando Portugal como estudo de caso. A questão principal é analisar como a extrema-direita em Portugal, apesar de seu pequeno número de grupos, abrange um enorme campo de estruturas mundiais. Existem, basicamente, dois eixos ideológicos principais altamente opostos entre si. Um eixo afirma que Portugal pertence a um universo etno-europeu branco que visa um Portugal amalgamado a um continente europeu no qual os brancos deveriam ser a maioria incontestável, se não toda a população. Seus seguidores são influenciados por escolas de pensamento da Europa e dos Estados Unidos. O outro eixo afirma que o povo português é especialmente propenso à miscigenação com europeus não brancos. Este eixo visa um Portugal amalgamado com seu antigo império nos trópicos e baseia seu ideal em pensamentos surgidos no Brasil. Concluo que ambas as linhas ideológicas dividem a direita grupuscular portuguesa e dão um tom muito particular à metapolítica. extremadireita extrema internet caso grupos mundiais Existem basicamente si etnoeuropeu etno incontestável população Unidos Brasil metapolítica

ABSTRACT The aim of this article is to contribute to the debate on race and ethnicity amidst Far-right internet organizations by using Portugal as a case study. The main issue is to analyze how the Far-right in Portugal, despite its small number of groupings, encompasses a huge overarching field of worldframes. There are, basically, two main ideological axes highly opposed to each other. One axis states that Portugal belongs to a white ethnoeuropean universe. It aims at a Portugal amalgamated to a European continent in which whites should be an undeniable majority, if not all its population. Its followers are influenced by schools of thought from Europe and the USA. The other axis states that the Portuguese people are especially prone to miscegenation with non-white Europeans. It aims at a Portugal amalgamated with its former Empire in the tropics and bases its ideal on thoughts emerged in Brazil. I conclude that both ideological lines cleave the Portuguese groupuscular right and give a very particular tone to Metapolitics. Farright Far study groupings worldframes basically universe majority population USA nonwhite non Europeans Brazil Metapolitics

Abstract Introduction: Acute kidney injury (AKI) is a frequent complication of severe COVID-19 and is associated with high case fatality rate (CFR). However, there is scarcity of data referring to the CFR of AKI patients that underwent kidney replacement therapy (KRT) in Brazil. The main objective of this study was to describe the CFR of critically ill COVID-19 patients treated with acute kidney replacement therapy (AKRT). Methods: Retrospective descriptive cohort study. We included all patients treated with AKRT at an intensive care unit in a single tertiary hospital over a 15-month period. We excluded patients under the age of 18 years, patients with chronic kidney disease on maintenance dialysis, and cases in which AKI preceded COVID-19 infection. Results: A total of 100 out of 1479 (6.7%) hospitalized COVID-19 patients were enrolled in this study. The median age was 74.5 years (IQR 64 – 82) and 59% were male. Hypertension (76%) and diabetes mellitus (56%) were common. At the first KRT prescription, 85% of the patients were on invasive mechanical ventilation and 71% were using vasoactive drugs. Continuous veno-venous hemodiafiltration (CVVHDF) was the preferred KRT modality (82%). CFR was 93% and 81 out of 93 deaths (87%) occurred within the first 10 days of KRT onset. Conclusion: AKRT in hospitalized COVID-19 patients resulted in a CFR of 93%. Patients treated with AKRT were typically older, critically ill, and most died within 10 days of diagnosis. Better strategies to address this issue are urgently needed. Introduction (AKI COVID19 COVID 19 COVID-1 CFR. . (CFR) However (KRT Brazil AKRT. (AKRT) Methods 15month month 15 period 1 dialysis infection Results 147 6.7% 67 6 7 (6.7% 745 74 5 74. IQR 82 59 male 76% 76 (76% 56% 56 (56% common prescription 85 71 drugs venovenous veno venous CVVHDF (CVVHDF 82%. 82% (82%) 8 9 87% 87 (87% onset Conclusion older diagnosis needed COVID1 COVID- (CFR (AKRT 14 6.7 (6.7 (76 (56 (82% (87 6. (6. (7 (5 (82 (8 (6 (

Resumo Introdução: Injúria renal aguda (IRA) é uma complicação frequente da COVID-19 grave e está associada a alta taxa de letalidade (TL). Entretanto, há escassez de dados referentes à TL de pacientes com IRA submetidos a suporte renal artificial (SRA) no Brasil. O objetivo principal deste estudo foi descrever a TL de pacientes graves com IRA por COVID-19 tratados com SRA. Métodos: Estudo de coorte descritivo retrospectivo. Incluímos todos os pacientes tratados com SRA em unidade de terapia intensiva de um único hospital terciário por 15 meses. Excluímos pacientes menores de 18 anos, pacientes com doença renal crônica em diálise de manutenção e casos nos quais a IRA precedeu a infeção por COVID-19. Resultados: Incluímos neste estudo um total de 100 dos 1479 (6,7%) pacientes hospitalizados com COVID-19. A mediana de idade foi 74,5 anos (IIQ 64 – 82) e 59% eram homens. Hipertensão (76%) e diabetes mellitus (56%) foram comuns. Na primeira prescrição de SRA, 85% dos pacientes estavam em ventilação mecânica invasiva e 71% em uso de drogas vasoativas. A hemodiafiltração contínua foi a modalidade de SRA preferida (82%). A TL foi de 93% e 81 dos 93 óbitos (87%) ocorreram nos primeiros 10 dias do início da SRA. Conclusão: O SRA em pacientes hospitalizados com IRA por COVID-19 resultou em TL de 93%. Os pacientes tratados com SRA eram geralmente idosos, gravemente enfermos e a maioria foi a óbito em até 10 dias após o diagnóstico. Estratégias melhores para abordar esse problema são urgentemente necessárias. Introdução (IRA COVID19 COVID 19 COVID-1 TL. . (TL) Entretanto (SRA Brasil Métodos retrospectivo 1 meses COVID19. 19. Resultados 147 6,7% 67 6 7 (6,7% 745 74 5 74, IIQ 82 59 homens 76% 76 (76% 56% 56 (56% comuns 85 71 vasoativas 82%. 82% (82%) 8 9 87% 87 (87% Conclusão idosos diagnóstico necessárias COVID1 COVID- (TL 14 6,7 (6,7 (76 (56 (82% (87 6, (6, (7 (5 (82 (8 (6 (

Problem: Preterm birth is the leading cause of death and can result in significant long-term loss of physical and psychological capacity among survivors.Background: An estimated 15 million babies are born preterm every year. Prediction models based on machine learning methods have reported promising results.Aims: To identify risk factors associated with preterm birth and to develop and validate a prediction model for this outcome in a Brazilian birth cohort.Methods: Cross-sectional study of all births that occurred in Ribeirão Preto-SP and of one in three births that occurred in São Luís-MA, Brazil, in 2010. Questionnaires were applied to obtain pregnancy-related data. Multivariate adaptive regression splines were used to determine the independent variables. Preterm birth, defined as birth before 37 weeks gestational age, was the dependent variable. A random forest model was developed and its performance was evaluated by ROC analysis.Findings: The preterm birth rates were 12.7% (RP) and 14.1% (SL). The prediction and validation accuracies of the RF-based model were 91.3% and 85.5% respectively. The model can be applied starting in the third month of gestation and is more effective in identifying preterm infants with GA<31 weeks and 6 days (AUC=0.98).Discussion: It was possible to build a prediction model based on easily accessible low-cost data, without the need for complementary tests, providing results similar to those of other studies.Conclusions: Previous preterm birth and prenatal care were determinants. The use of an application for individualized patient monitoring an early stage can have positive effects on the quality of life of mother and child.

ABSTRACT The Middle Pleistocene (780-130 ka) was a key period in human evolutionary history. The period holds a great diversity of hominin species, technological innovations, in addition to being, after all, when Homo sapiens appeared on the planet. However, Pleistocene populations, as well as the biological relationships between them, remain poorly understood. Here, we bring a brief summary of human evolution with special attention to the Middle Pleistocene issues, advances in the field and the Brazilian contribution to this debate. 780130 780 130 (780-13 ka history species innovations being all planet However populations them understood Here issues debate 78013 78 13 (780-1 7801 7 1 (780- (780 (78 (7 (

RESUMO O Pleistoceno Médio (780-130 mil anos) foi um período-chave na história evolutiva humana. O período abriga uma grande diversidade de espécies hominínias, inovações tecnológicas, além de ser, afinal, quando o Homo sapiens surgiu no planeta. Entretanto, as populações pleistocênicas, bem como as relações biológicas entre elas, permanecem precariamente compreendidas. Aqui, trazemos uma breve síntese da evolução humana com especial atenção às questões do Pleistoceno Médio, os avanços da área e a contribuição brasileira a esse debate. 780130 780 130 (780-13 anos períodochave chave hominínias tecnológicas ser afinal planeta Entretanto pleistocênicas elas compreendidas Aqui debate 78013 78 13 (780-1 7801 7 1 (780- (780 (78 (7 (

Abstract This paper presents a numerical study and the optimization of very short discrete multi-pump Raman amplifiers using Tellurite-based optical fibers. While most studies about discrete Raman amplifiers usually focus on cases where hundreds of meters of fiber are used, here we consider a multi-pumped Raman amplifier setup with extremely short dimensions, in which the length of the gain media was varied from 2.5 to 30 meters. The optimization process was developed over an broad amplification band from 1520 to 1600 nm, considering a maximum acceptable ripple of 3 dB, and using 2, 3 and 4 pumps with individual powers always below 2.5 W. The results show that it is possible to achieve net gains as high as 10 dB for gain media around 20 meters, and close to 15 dB for 30 meters. These high gains highlight the fact that Tellurite-based optical fibers can be used for the construction of very short and compact broadband amplifiers using just a few pump lasers with modest optical powers. multipump multi Telluritebased Tellurite based multipumped pumped dimensions 25 2 5 2. 152 160 nm W 1 16

Abstract Large segmental tracheal defects can pose a serious clinical challenge owing to the lack of suitable substitutes for reconstructive surgery. Polymeric biomaterials are widely used in medicine. However, the implantation of biomaterials triggers a series of biological events, and material biocompatibility is of paramount importance in regenerative medicine. The objective of this study was to evaluate the use of a copolyamide associated with thermoplastic elastomer (PCTPE) in 3D-printed prostheses for repairing partial tracheal defects in rabbits. Sixteen male New Zealand White rabbits were used, and partial tracheal defects were created in the ventral region from the 4th to the 8th tracheal ring. The animals were subdivided into groups (n=4) based on the time of euthanasia, scheduled at seven days (G7), 15 days (G15), 30 days (G30), and 60 days (G60). Histopathological analysis with hematoxylin and eosin staining revealed that the 3D implant of PCTPE exhibited a foreign body reaction, and inflammation persisted for up to 60 days. Histochemistry with picrosirius red revealed a tendency for a greater amount of type I collagen to accumulate in the early stages of inflammation, whereas type III collagen was predominant in later evaluation periods. These findings suggest an exacerbated and inadequate tissue-material interface reaction and perpetuation of the inflammatory process. surgery medicine However events (PCTPE 3Dprinted Dprinted printed D th ring n=4 n4 n 4 (n=4 euthanasia G7, G7 G , (G7) 1 G15, G15 (G15) 3 G30, G30 (G30) 6 G60. G60 . (G60) periods tissuematerial tissue process n= (n= (G7 G1 (G15 G3 (G30 G6 (G60 (n (G (G1 (G3 (G6

Resumo Defeitos de grandes segmentos traqueais podem apresentar sério problema clínico, devido à ausência de substitutos na cirurgia reconstrutiva. Os biomateriais poliméricos estão entre os mais utilizados na medicina. Entretanto, a implantação de um biomaterial desencadeia uma série de eventos biológicos e a biocompatibilidade do material é de extrema importância para a medicina regenerativa. Objetivou-se com este estudo avaliar o uso da copoliamida associada ao elastômero termoplástico (PCTPE) em próteses impressas em 3D para reparação de defeitos parciais da traqueia de coelhos. Foram utilizados 16 coelhos machos da raça Nova Zelândia Branco, submetidos à criação de um defeito parcial de traqueia na região ventral do 4º ao 8º anel traqueal. Os animais foram subdivididos (n=4) de acordo com o momento das eutanásias, programadas com intervalo de sete (G7), quinze (G15), trinta (G30) e sessenta dias (G60). A análise histopatológica por hematoxilina e eosina (HE) revelou que o implante 3D de PCTPE apresentou reação do tipo corpo estranho e a inflamação persistiu até os 60 dias de avaliação. A histoquímica de picrosirius vermelho revelou tendência de maior quantidade de colágeno tipo I nos tempos iniciais de inflamação, enquanto o colágeno tipo III foi predominante nos períodos tardios de avaliação. Pode-se sugerir reação exacerbada e não adequada da interface tecido-material e perpetuação do processo inflamatório. clínico reconstrutiva Entretanto regenerativa Objetivouse Objetivou se (PCTPE D 1 Branco º traqueal n=4 n4 n 4 (n=4 eutanásias G7, G7 G , (G7) G15, G15 (G15) G30 (G30 G60. G60 . (G60) HE (HE 6 avaliação Podese Pode tecidomaterial tecido inflamatório n= (n= (G7 G1 (G15 G3 (G3 G6 (G60 (n (G (G1 (G6

ABSTRACT A 41 year-old man presented with unilateral vision loss for a week and constitutional symptoms for 3 months. Ophthalmic evaluation revealed cotton wool spots on the right eye and widespread retinal necrosis and hemorrhage on the left eye, suggestive of cytomegalovirus uveitis and HIV infection and retinopathy, and confirmed by serology. The patient was treated with ganciclovir and highly active antiretroviral therapy and preserved contralateral vision. Clinicians should be aware of uveitis and retinopathies to prevent irreversible vision loss and systemic conditions. 4 yearold year old months retinopathy serology conditions

RESUMO Paciente do sexo masculino, 41 anos, com queixa de perda de acuidade visual unilateral por 1 semana e sintomas constitucionais por 3 meses. Ao exame oftalmológico, apresentava exsudatos algodonosos, em olho direito, e áreas de necrose e hemorragias retinianas, em olho esquerdo, com suspeita de uveíte por citomegalovírus e retinopatia por HIV, confirmadas por sorologias. O paciente foi tratado com ganciclovir e terapia antirretroviral e preservou a visão contralateral. Os oftalmologistas devem estar atentos para casos de uveítes e retinopatias, para prevenirem perda visual irreversível e condições sistêmicas. masculino 4 anos meses oftalmológico algodonosos direito retinianas esquerdo HIV sorologias contralateral retinopatias sistêmicas

Abstract Introduction Appendicitis is the surgical disease with the highest prevalence in emergency rooms. Its clinical and/or surgical complications are associated with the time course of symptoms, age, comorbidities, and stages of the disease. Objectives To analyze the demographic and clinical data of patients who underwent appendectomy for acute appendicitis in a tertiary referral hospital in the city of São Paulo and compare these data between services provided by the Public and Supplementary Health System. Methodology Retrospective analysis of data from electronic medical records of patients over 14 years old who underwent appendectomy for acute appendicitis at Hospital Santa Marcelina, both in the Public and Supplementary Health Systems from January 2015 to December 2017. Results A total of 536 patients were analyzed, 354 (66%) of whom were male with a general mean age of 29.85 years (14-81 years). The mean time from symptoms to seeking medical care was 53.84 hours. Regarding the phases of acute appendicitis, a greater number of cases of complicated disease was observed in patients operated on in the Public Health System (p < 0.0001), as well as the time course of symptoms (p = 0.0005) and Conclusion There was a predominance of male patients undergoing appendectomy for acute appendicitis, with longer time course of symptoms in those operated on in the Public Health System and a predominance of appendicitis in advanced stages (3 and 4) in this group. However, in this group there was no significant increase in the rate of postoperative infection, and the length of stay was shorter than that of patients operated on in the Supplementary Health System. rooms andor or comorbidities 1 Marcelina 201 2017 53 analyzed 35 66% 66 (66% 2985 29 85 29.8 1481 81 (14-8 years. . years) 5384 84 53.8 hours p 0.0001, 00001 0.0001 , 0 0001 0.0001) 0.0005 00005 0005 3 ( 4 However infection 20 5 6 (66 298 2 8 29. 148 (14- 538 53. 0000 0.000 000 (6 (14 0.00 00 (1 0.0 0.

ABSTRACT The standardized precipitation (SPI) and standardized precipitation-evapotranspiration (SPEI) indices are important tools for monitoring drought events, but the low density of weather station networks limits their use in many regions. To address this issue, we developed the PowerSDI R-package, which calculates these two indices using gridded-data from the NASA-POWER project (NASA-SPI and NASA-SPEI). Different from other packages, the PowerSDI package has two modes: the scientific, and the operational. In the scientific mode, the users may assess the quality of the indices estimates through their agreement with a reference/observed series and through the evaluation of how well these estimates meet the conceptual assumptions required for calculating both SPI and SPEI. This evaluation is based on measure of accuracy (e.g., Willmott index of agreement), goodness-of-fit tests (e.g., Anderson-Darling), and normality tests (e.g., Shapiro-Wilk’s test), which are calculated by the ScientSDI.R, Reference.R, and Accuracy.R functions. In the operational mode, users can calculate both indices routinely using the OperatSDI.R function. The package also uses a quasi-weekly time scale, allowing for index calculations four times a month. The OperatSDI.R enables users to download NASA-POWER data for all available period or only for the quasi-week they intend to monitor (reducing the function’s running time). In short, the PowerSDI facilitates the routine use of these two widely used drought indices and, unlike others existing software, it provides a solid scientific basis for using NASA-POWER data in drought monitoring systems, which can help improve drought preparedness and response efforts worldwide. The package is freely available at two repositories: Github (https://github.com/gabrielblain/PowerSDI), and CRAN (https://CRAN.R-project.org/package=PowerSDI). (SPI precipitationevapotranspiration evapotranspiration SPEI (SPEI events regions issue Rpackage, Rpackage R package, R-package griddeddata gridded NASAPOWER NASA POWER NASASPI NASASPEI. NASASPEI . NASA-SPEI) packages modes mode referenceobserved reference observed e.g., eg e g (e.g. agreement, , agreement) goodnessoffit goodness fit AndersonDarling, AndersonDarling Anderson Darling Anderson-Darling) ShapiroWilks Shapiro Wilk s test, test test) ScientSDIR ScientSDI ScientSDI.R ReferenceR Reference Reference.R AccuracyR Accuracy functions OperatSDIR OperatSDI function quasiweekly quasi weekly scale month quasiweek week reducing time. time) short software systems worldwide repositories https//github.com/gabrielblain/PowerSDI, httpsgithubcomgabrielblainPowerSDI https //github.com/gabrielblain/PowerSDI github com gabrielblain (https://github.com/gabrielblain/PowerSDI) https//CRAN.Rproject.org/package=PowerSDI. httpsCRANRprojectorgpackagePowerSDI //CRAN.R project.org/package=PowerSDI org (https://CRAN.R-project.org/package=PowerSDI) NASA-SPEI e.g. (e.g Anderson-Darling https//github.com/gabrielblain/PowerSDI githubcomgabrielblainPowerSDI (https://github.com/gabrielblain/PowerSDI Rproject https//CRAN.Rproject.org/package=PowerSDI CRANR projectorgpackagePowerSDI (https://CRAN.R-project.org/package=PowerSDI e.g

Abstract: Plant and fruit quality is a reflection of several factors, one of which is the way the seedlings were produced. The aim of this study was to analyse the phytotechnical and nutritional characteristics of fig tree seedlings (Ficus carica L.) produced in a substrate comprising decomposed stems of the buriti palm (Mauritia flexuosa L.). A randomised block design was used, with treatments distributed in a 5x6 factorial scheme with one additional treatment, arranged in five blocks. The substrates included the following levels of decomposed buriti stems: 20%, 40%, 60%, 80% and 100%, with a different decomposition time (0; 15; 30; 45; 60 and 75 days) for each treatment. There was one additional treatment comprising 100% soil. The following variables were evaluated to determine the effects of the treatments: number of leaves (NL), number of branches (NB), leaf chlorophyll index, diameter of the largest shoot (DLS), length of the largest shoot (LLS), leaf area (LA), root length (RL), root volume (RV), shoot fresh matter (SFM), root fresh matter (RFM), shoot dry matter (SDM) and root dry matter (RDM), with a chemical analysis of the shoots and soil before and after setting up the experiment. The proportion of decomposed buriti palm stem in the substrate yielded significant results for the morphological variables, including the number of leaves, shoot fresh matter, root fresh matter and root volume. For the nutritional variables relating to the aerial part of the seedlings, the proportion of substrate yielded significant results for the levels of calcium, magnesium, iron and zinc. There were no significant results from the decomposition time; however, multivariate analysis showed that by the end of the experiment the nutrient concentration in the soil was higher than before the experiment. Abstract factors Ficus L. L Mauritia L.. . used x 5x blocks 20 20% 40 40% 60% 80 100 0 (0 15 30 45 6 7 days NL, NL , (NL) NB, NB (NB) index DLS, DLS (DLS) LLS, LLS (LLS) LA, LA (LA) RL, RL (RL) RV, RV (RV) SFM, SFM (SFM) RFM, RFM (RFM) SDM (SDM RDM, RDM (RDM) calcium magnesium zinc however 2 4 8 10 ( 1 3 (NL (NB (DLS (LLS (LA (RL (RV (SFM (RFM (RDM

Resumo: A qualidade da planta e dos frutos é reflexo de vários fatores, sendo um deles a forma como foi produzida a muda. Objetivou-se analisar as características fitotécnicas e nutricionais da muda de figueira (Ficus carica L.) produzida com substrato de cauledecomposto de buriti (Mauritia flexuosa L.). Utilizou-se o delineamento em blocoscasualizados, com tratamentos distribuídos em sistema fatorial 5x6 mais um adicional, dispostosem 5 blocos. Os substratos foram formados nas seguintes proporções de caule decomposto de buriti:20%, 40%, 60%, 80% e 100%, e cada proporção, oriunda de diferentes tempos dedecomposição:0; 15; 30; 45; 60 e 75 dias, além do adicional composto por 100% de solo. Para a determinação dos efeitos dos tratamentos, foram avaliadas as seguintesvariáveis: Número de folhas (NF), Número de ramos (NR), índice de clorofila foliar, diâmetro domaior broto(DMB), Comprimento do maior broto (CMB), Área foliar (AF), Comprimento da raiz(CRZ),Volume radicular (VRZ), Massa fresca da parte aérea (MFPA), Massa fresca daraiz (MFRZ), Matéria seca da parte aérea (MSPA), Matéria seca da raiz (MSRZ) e análise química da parte aérea e do solo, antes e após a montagem do experimento. As proporções decaule decomposto de buriti no substrato proporcionaram resultados significativos para asvariáveis morfológicas,número de folhas, massa fresca da parte aérea, massa fresca da raiz e volumeradicular. Para as variáveis nutricionais referentes à parte aérea das mudas, as proporções de substrato também favoreceram resultados significativos para os teores decálcio, magnésio, ferro e zinco. Os tempos de decomposição não proporcionaram resultados significativos;mas, através da análise multivariada, pôde-se observar que, ao final doexperimento, havia maior concentração de nutrientes no solo em relação ao mesmo antes da montagem. Resumo fatores Objetivouse Objetivou se Ficus L. L Mauritia L.. . Utilizouse Utilizou blocoscasualizados x 5x blocos buriti20%, buriti20 20%, 20 buriti:20% 40 40% 60% 80 100 proporção dedecomposição0 dedecomposição 0 dedecomposição:0 15 30 45 6 7 dias seguintesvariáveis NF, NF , (NF) NR, NR (NR) brotoDMB, brotoDMB DMB broto(DMB) CMB, CMB (CMB) AF, AF (AF) raizCRZ,Volume raizCRZVolume CRZ ,Volume Volume VRZ, VRZ (VRZ) MFPA, MFPA (MFPA) MFRZ, MFRZ (MFRZ) MSPA, MSPA (MSPA) MSRZ (MSRZ experimento morfológicasnúmero morfológicas número volumeradicular mudas decálcio magnésio zinco significativosmas, significativosmas mas, mas significativos;mas multivariada pôdese pôde que doexperimento buriti20% buriti2 20% 2 buriti:20 4 8 10 dedecomposição: 1 3 (NF (NR broto(DMB (CMB (AF raizCRZ (VRZ (MFPA (MFRZ (MSPA buriti:2 buriti:

Abstract This study examines the adequacy, readability, and quality of the information provided on package inserts for veterinary medicines in Brazil. It aims to identify the essential information required in these documents and assess non-compliance with regulatory standards. Initially, a documentary analysis was conducted to identify mandatory information as per Federal Decree No. 5,053/2004 and Normative Instruction No. 26/2009 of the Ministry of Agriculture, Livestock and Supply. Subsequently, 256 package inserts were analyzed to evaluate their suitability using descriptive quantitative analysis. This analysis showed a lack of essential technical and scientific information, necessary for the rational use of veterinary medicines. Mandatory elements supporting the correct use of veterinary medicines and essential information, such as a qualitative description of excipients, equivalence factors, the mass of active pharmaceutical ingredient per volume (when applicable), and information about the customer service center, were absent from these documents. This study found at least one non-conformity in the 252 evaluated package inserts. These findings underscore the significant lack of adherence to established rules and the low quality of technical-scientific information, reducing the comprehension of both prescribers and owners. The authors highlight the need for regulatory agencies to review and improve the guidelines that govern the format and content of package inserts. adequacy readability Brazil noncompliance non compliance standards Initially No 50532004 5 053 2004 5,053/200 262009 26 2009 26/200 Agriculture Supply Subsequently 25 excipients factors when applicable, applicable , applicable) center nonconformity conformity technicalscientific owners 5053200 05 200 5,053/20 26200 2 26/20 505320 0 20 5,053/2 2620 26/2 50532 5,053/ 262 26/ 5053 5,053 505 5,05 50 5,0 5,

Abstract Objective To review current literature to support the use of mesna as a preventive therapy for hemorrhagic cystitis and bladder cancer in patients with systemic autoimmune diseases and systemic vasculitis treated with cyclophosphamide. Materials and methods The search for articles was conducted systematically through MEDLINE, LILACS, Cochrane Library, and Embase databases. Only articles in English were selected. For available records, titles and abstracts were selected independently by two investigators. Results Eighteen studies were selected for analysis. The known adverse effects of cyclophosphamide were hematological toxicity, infections, gonadal toxicity, teratogenicity, increased risk for malignancy and hemorrhagic cystitis. Long-term toxicity was highly dependent on cyclophosphamide cumulative dose. The risk of bladder cancer is especially higher in long-term exposure and with cumulative doses above 36 g. The risk remains high for years after drug discontinuation. Hemorrhagic cystitis is highly correlated with cumulative dose and its incidence ranges between 12 and 41%, but it seems to be lower with new regimens with reduced cyclophosphamide dose. No randomized controlled trials were found to analyze the use of mesna in systemic autoimmune rheumatic diseases and systemic vasculitis. Retrospective studies yielded conflicting results. Uncontrolled prospective studies with positive results were considered at high risk of bias. No evidence was found to support the use of mesna during the treatment with cyclophosphamide for autoimmune diseases or systemic vasculitis to prevent hemorrhagic cystitis and bladder cancer. In the scenarios of high cumulative cyclophosphamide dose (i.e., > 30 g), patients with restricted fluid intake, neurogenic bladder, therapy with oral anticoagulants, and chronic kidney disease, mesna could be considered. Conclusion The current evidence was found to be insufficient to support the routine use of mesna for the prophylaxis of hemorrhagic cystitis and bladder cancer in patients being treated for systemic autoimmune diseases and systemic vasculitis with cyclophosphamide. The use may be considered for selected cases. MEDLINE LILACS Library databases records investigators analysis infections teratogenicity Longterm Long term longterm long 3 g discontinuation 1 41 41% bias i.e., ie i e (i.e. g, , g) intake anticoagulants disease cases 4 i.e. (i.e i.e