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RESUMO Objetivo: Avaliar as doenças autoinflamatórias (DAI) de acordo com sexo e idade no momento do diagnóstico e a resposta terapêutica em uma grande população. Métodos: Este é um estudo observacional transversal de um registro latino-americano que usou um sistema de dados coletados entre 2015 e 2018. Quaisquer achados alterados ao longo do acompanhamento foram registrados. Os formulários foram traduzidos para os idiomas português e espanhol, incluindo características demográficas, clínicas, laboratoriais, genéticas e de tratamento. Resultados: Incluímos 152 pacientes, sendo 51,3% do sexo masculino e 75% da raça branca. A média de idade de início da doença foi de 2,1 anos (0–15,6 anos) e a média de idade de diagnóstico 6,9 anos (0–21,9 anos); 111 (73%) eram crianças (0–9 anos) e 41 (27%) adolescentes/adultos jovens (10–21 anos). A síndrome de febre periódica, estomatite aftosa, faringite e adenite (PFAPA) ocorreu em 46/152 (30%), osteomielite não bacteriana crônica (CNO) em 32/152 (21%) e febre familiar do Mediterrâneo (FMF) em 24/152 (15,7%). A PFAPA foi significativamente maior em crianças pequenas (38,7 vs. 7,3%, p<0,001), e a CNO, em adolescentes/adultos jovens (13,5 vs. 41,5%, p<0,001). A frequência do sexo feminino foi significativamente maior na CNO (28,4 vs. 14,1%, p=0,031) e menor na FMF (8,1 vs. 23,1%, p=0,011). Os medicamentos mais utilizados foram glicocorticoides, anti-inflamatórios não esteroidais (AINE) e colchicina. O tratamento com glicocorticoides e colchicina foi usado em todas as DAI com resposta boa a moderada. No entanto, as síndromes periódicas associadas à criopirina (CAPS) pareciam não responder aos glicocorticoides. AINE e metotrexato foram os principais medicamentos utilizados no tratamento da CNO. Conclusões: Diferenças de pacientes com DAI foram observadas na população latino-americana em pacientes agrupados por sexo e idade ao diagnóstico da doença. Objetivo (DAI Métodos latinoamericano latino americano 201 2018 registrados espanhol demográficas clínicas laboratoriais Resultados 15 513 51 3 51,3 75 branca 21 2 1 2, 0–15,6 0156 0 6 (0–15, 69 9 6, 0–21,9 0219 (0–21, 11 73% 73 (73% 0–9 09 (0– 4 27% 27 (27% adolescentesadultos adolescentes adultos 10–21 1021 10 (10–2 anos. . periódica aftosa (PFAPA 46152 46 46/15 30%, 30 30% , (30%) (CNO 32152 32 32/15 21% (21% (FMF 24152 24 24/15 15,7%. 157 15,7% 7 (15,7%) 38,7 387 38 (38, vs 7,3% p<0,001, p0001 p p<0,001 001 p<0,001) 13,5 135 13 5 (13, 415 41,5% p<0,001. 28,4 284 28 (28, 141 14 14,1% p=0,031 p0031 031 8,1 81 8 (8, 231 23 23,1% p=0,011. p0011 p=0,011 011 p=0,011) antiinflamatórios anti inflamatórios (AINE moderada entanto CAPS (CAPS Conclusões latinoamericana americana 20 51, 0–15, 015 (0–15 0–21, 021 (0–21 (73 0– (0 (27 10–2 102 (10– 4615 46/1 (30% 3215 32/1 (21 2415 24/1 15,7 (15,7% 38, (38 7,3 p000 p<0,00 00 13, (13 41,5 28, (28 14,1 p=0,03 p003 03 8, (8 23,1 p001 p=0,01 01 0–15 (0–1 0–21 02 (0–2 (7 ( (2 10– (10 461 46/ (30 321 32/ 241 24/ 15, (15,7 (3 7, p00 p<0,0 (1 41, 14, p=0,0 23, 0–1 0–2 (15, p0 p<0, p=0, (15 p<0 p=0 p< p=

ABSTRACT Objective: To evaluate autoinflammatory diseases (AID) according to age at diagnosis and sex, and response to therapy in a large population. Methods: This is a cross-sectional observational study of a Latin American registry using a designed web system for data storage, collected between 2015 and 2018. Any altered findings during follow-up were recorded. The forms were translated into Portuguese and Spanish, including demographic, clinical, laboratory, genetic and treatment characteristics. Results: We included 152 patients, 51.3% male and 75% Caucasian. The median age at disease onset was 2.1 years (0–15.6 years) and median age at diagnosis 6.9 years (0–21.9 years); 111 (73%) were children (0–9 years old), and 41 (27%) were adolescents and young adults (AYA) (10–21 years old). Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome (PFAPA) occurred in 46/152 (30%), chronic non-bacterial osteomyelitis (CNO) in 32/152 (21%), and familial Mediterranean fever (FMF) in 24/152 (15.7%). PFAPA was significantly higher in young children than in AYA (38.7% vs. 7.3%, p<0.001), while CNO were lower (13.5% vs. 41.5%, p<0.001). The frequency of females was significantly higher in CNO (28.4% vs. 14.1%, p=0.031) and lower in FMF (8.1% vs. 23.1%, p=0.011). The most used drugs were glucocorticoids, non-steroidal anti-inflammatory drugs (NSAID), and colchicine. Glucocorticoids and colchicine treatment were used in all AID with good to moderate response. However, cryopyrin-associated periodic syndromes (CAPS) seemed unresponsive to glucocorticoids. NSAIDs and methotrexate were the main medications used to treat CNO. Conclusions: Differences among AID patients were observed in the LA population regarding sex and age at disease diagnosis. Objective (AID Methods crosssectional cross sectional storage 201 2018 followup follow up recorded Spanish demographic clinical laboratory characteristics Results 15 513 51 3 51.3 75 Caucasian 21 2 1 2. 0–15.6 0156 0 6 (0–15. 69 9 6. 0–21.9 0219 (0–21. 11 73% 73 (73% 0–9 09 (0– old, old , old) 4 27% 27 (27% (AYA 10–21 1021 10 (10–2 old. . stomatitis pharyngitis (PFAPA 46152 46 46/15 30%, 30 30% (30%) nonbacterial non bacterial (CNO 32152 32 32/15 21%, 21% (21%) (FMF 24152 24 24/15 15.7%. 157 15.7% 7 (15.7%) 38.7% 387 38 (38.7 vs 7.3% p<0.001, p0001 p p<0.001 001 p<0.001) 13.5% 135 13 5 (13.5 415 41.5% p<0.001. 28.4% 284 28 (28.4 141 14 14.1% p=0.031 p0031 031 8.1% 81 8 (8.1 231 23 23.1% p=0.011. p0011 p=0.011 011 p=0.011) glucocorticoids nonsteroidal steroidal antiinflammatory anti inflammatory NSAID, NSAID (NSAID) However cryopyrinassociated cryopyrin associated CAPS (CAPS Conclusions 20 51. 0–15. 015 (0–15 0–21. 021 (0–21 (73 0– (0 (27 10–2 102 (10– 4615 46/1 (30% 3215 32/1 (21% 2415 24/1 15.7 (15.7% 38.7 (38. 7.3 p000 p<0.00 00 13.5 (13. 41.5 28.4 (28. 14.1 p=0.03 p003 03 8.1 (8. 23.1 p001 p=0.01 01 (NSAID 0–15 (0–1 0–21 02 (0–2 (7 ( (2 10– (10 461 46/ (30 321 32/ (21 241 24/ 15. (15.7 38. (38 7. p00 p<0.0 13. (13 41. 28. (28 14. p=0.0 8. (8 23. 0–1 0–2 (1 (3 (15. p0 p<0. p=0. (15 p<0 p=0 p< p=

https://doi.org/10.1590/1984-0462/2024/42/2022184

Caracterización sociodemográfica y clínica de pacientes con tuberculosis atendidos en una institución de salud de Barranquilla, Colombia
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Blanco-Charry, Saray Michelle

; Rojas-Avila, Daniela Paola

; Alzate Rios, María Juliana

; Tellez-Coronado, Dagoberto Arturo

; Vilaró-Otero, Michelle Marie

; Guillen-Burgos, Hernan Felipe

; Maestre-Serrano, Ronald

Revista Cubana de Medicina Tropical

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2024, Volume 76 elocation e933

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Tuberculosis is mainly a pulmonary disease caused by the bacterium Mycobacterium tuberculosis, which can affect any individual. Objective: To describe the sociodemographic and clinical characteristics of patients diagnosed with tuberculosis reported in a healthcare institution in the district of Barranquilla, Colombia. Methods: A descriptive study that retrospectively reviewed the surveillance system database of patients diagnosed with tuberculosis in a healthcare institution in the district of Barranquilla between 2017 and 2019. Results: A total of 147 patients were reported. Of them, 68% were male and 32% were female. The majority of patients were in the age range of 20 to 44 years (45.6%). Unskilled workers accounted for 83.7% of the sample, and 67.3% were affiliated with the subsidized health insurance scheme. Pulmonary tuberculosis was found in 72.8% of the patients and extrapulmonary tuberculosis in 27.2%. Concomitant HIV infection was reported in 21.1% of the patients. The most common comorbidities were diabetes (7.5%) and malnutrition (6.8%). All patients had drug-susceptible tuberculosis. Conclusion: The results of this study showed sociodemographic and clinical patterns similar to those reported in Colombia; thus, they are valuable tools to strengthen surveillance and control strategies for this public health concern.

RESUMEN Introducción: La tuberculosis es una enfermedad principalmente pulmonar, causada por la bacteria Mycobacterium tuberculosis, que puede afectar a cualquier persona. Objetivo: Describir las características sociodemográficas y clínicas de pacientes con diagnóstico de tuberculosis notificados en una institución de salud del distrito de Barranquilla, Colombia. Métodos: Estudio descriptivo en el que se revisó de forma retrospectiva la base de datos del sistema de vigilancia de pacientes con diagnóstico de tuberculosis en una institución de salud del distrito de Barranquilla durante los años 2017 y 2019. Resultados: Se notificaron 147 pacientes, de los cuales, el 68 % eran hombres y el 32 % mujeres. La edad de la mayoría de los pacientes osciló entre los 20 y 44 años (45,6 %). El 83,7 % eran trabajadores no calificados y el 67,3 % estaban afiliados al régimen subsidiado en salud. El 72,8 % de los pacientes tenía tuberculosis pulmonar y el 27,2 % extrapulmonar. La infección concomitante con VIH se registró en el 21,1 % de los pacientes y entre las comorbilidades más frecuentes se registraron la diabetes (7,5 %) y la desnutrición (6,8 %). Todos los pacientes presentaron tuberculosis sensible al tratamiento. Conclusión: Los resultados descritos en el presente estudio tuvieron un comportamiento sociodemográfico y clínico similar a los registrados en Colombia, los cuales sirven como herramienta para fortalecer las estrategias de vigilancia y control de este evento de interés en salud pública.

Can the combination of proanthocyanidin and vitamin E or palm oil effectively protect enamel against in vitro erosive and abrasive challenges? challenges
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MARTINS, Daiana da Silva

; BOTEON, Ana Paula

; FERREIRA, Amanda Moura

; DEBORTOLLI, Ana Luiza Bogaz

; GRIZZO, Isabella Claro

; IONTA, Franciny Querobim

; CARVALHO, Thiago Saads

; BUZALAF, Marilia Afonso Rabelo

; RIOS, Daniela

; HONÓRIO, Heitor Marques

Journal of Applied Oral Science

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2024, Volume 32 elocation e20240100

Resumo: En | Texto: En | PDF: En

Abstract Objectives This study aimed to assess the effect of proanthocyanidin, palm oil and vitamin E against erosive and erosive+abrasive challenges in vitro after enamel pellicle formation in situ. Methodology Bovine enamel blocks (n=84) were obtained and divided into the following treatment groups: negative control (NC) - deionized water; positive control (PC) - SnCl2/NaF/AmF-containing solution; palm oil (PO); 2% proanthocyanidin (P2); vitamin E (VitE); 2% proanthocyanidin+palm oil (P2PO); and 2% proanthocyanidin+vitamin E (P2VitE). For 5 days, one half of the sample from each group was subjected to erosion and the other half was subjected to erosion+abrasion. The acquired enamel pellicle (AEP) was pre-formed in situ for 30 minutes. The specimens were then treated in vitro with solutions (500 µl, 30s for each group). Subsequently, the blocks were left in the oral cavity for another hour to obtain the modified AEP. The blocks were immersed in 0.5% citric acid (pH=2.5) for 90s, 4×/day. AEP formation and treatment were carried out before the first and third erosive challenges, and after these challenges, abrasive cycles (15s) were performed on half of the samples. Enamel wear was quantified by profilometry and data were analyzed by two-way ANOVA and Tukey’s test (p<0.05). Results All groups showed higher wear when exposed to erosion+abrasion than when exposed to erosion alone (p=0.0001). PO, P2VitE, P2, and P2PO showed enamel wear similar to the PC group, but only PC, PO and P2VitE differed from the NC group. The other groups behaved similarly to NC. Conclusion It was concluded that the combination of proanthocyanidin and vitamin E was effective in reducing wear in the face of in vitro erosive and erosive+abrasive challenges. erosiveabrasive n=84 n84 n 84 (n=84 (NC water (PC SnCl2/NaF/AmFcontaining SnCl2NaFAmFcontaining SnClNaFAmFcontaining SnCl2/NaF/AmF containing SnCl2 NaF AmF SnCl solution (PO) 2 P2 P (P2) VitE (VitE) proanthocyanidinpalm PPO (P2PO) proanthocyanidinvitamin P2VitE. PVitE . (P2VitE) days erosionabrasion abrasion (AEP preformed pre formed 3 minutes 500 (50 µl s group) Subsequently 05 0 0.5 pH=2.5 pH25 pH (pH=2.5 90s 4day day 4 4×/day 15s (15s samples twoway two way Tukeys Tukey p<0.05. p005 p p<0.05 (p<0.05) p=0.0001. p00001 p=0.0001 0001 (p=0.0001) n=8 n8 8 (n=8 AmFcontaining NaFAmFcontaining SnCl2NaFAmF SnClNaFAmF (PO (P2 (VitE (P2PO (P2VitE 50 (5 0. pH=2. pH2 (pH=2. p00 p<0.0 (p<0.05 p0000 p=0.000 000 (p=0.0001 n= (n= NaFAmF (P ( pH=2 (pH=2 p0 p<0. (p<0.0 p000 p=0.00 00 (p=0.000 (n pH= (pH= p<0 (p<0. p=0.0 (p=0.00 (pH p< (p<0 p=0. (p=0.0 (p< p=0 (p=0. (p p= (p=0 (p=

https://doi.org/10.1590/1678-7757-2024-0100

Is Cavity Lining Really Necessary After Selective Caries Removal in Primary Teeth? Teeth
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Lourenço Neto, Natalino

; Jorge, Paula Karine

; Ambrosio, Eloá Cristina Passucci

; Vitor, Luciana Lourenço Ribeiro

; Rios, Daniela

; Cruvinel, Thiago

; Machado, Maria Aparecida Andrade Moreira

; Oliveira, Thais Marchini

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2024, Volume 24 elocation e230128

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To evaluate the clinical and radiographic response of pulp-dentin complex after selective caries removal with or without pulp lining in primary teeth. Material and Methods: Twenty-four primary molars with deep occlusal caries lesions and without pulpal alterations were selected from children, both genders, aged between 5 and 9 years old. After selective caries removal, the teeth were divided into three groups: without cavity liner (Group I), calcium hydroxide cement - CH (Group II), and Mineral trioxide aggregate - MTA (Group III). The final restoration was performed with resin-modified glass ionomer cement. Clinical and radiographic assessments were conducted at 6-month follow-up. The Kappa test determined intraexaminer reliability. Fisher's exact test evaluated intergroup comparisons (p<0.05). Results: All teeth showed clinical and radiographic success at the 6-month follow-up without statistically significant differences (p>0.05). Conclusion: Selective caries removal without cavity lining was acceptable for deep caries lesions in primary teeth. Objective pulpdentin dentin Methods Twentyfour Twenty four children genders old groups Group I, I , I) II, II II) III. III . III) resinmodified resin modified 6month month 6 followup. followup follow up. up reliability Fishers Fisher s p<0.05. p005 p p<0.05 0 05 (p<0.05) Results p>0.05. p>0.05 (p>0.05) Conclusion p00 p<0.0 (p<0.05 p>0.0 (p>0.05 p0 p<0. (p<0.0 p>0. (p>0.0 p<0 (p<0. p>0 (p>0. p< (p<0 p> (p>0 (p< (p> (p

https://doi.org/10.1590/pboci.2024.057

Rare diseases: What rheumatologists need to know? diseases know
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Nascimento, Renan Rodrigues Neves Ribeiro do

; Piotto, Daniela Gerent Petry

; Freire, Eutilia Andrade Medeiros

; Neves, Fabricio de Souza

; Sztajnbok, Flavio Roberto

; Bica, Blanca Elena Rios Gomes

; Pinheiro, Frederico Augusto Gurgel

; Kozu, Katia Tomie

; Pereira, Ivanio Alves

; Azevedo, Valderilio Feijo

; Cordeiro, Rafael Alves

; Giardini, Henrique Ayres Mayrink

; Franco, Marco Túlio Muniz

; Carvalho, Margarida de Fátima Fernandes

; Rosa-Neto, Nilton Salles

; Perazzio, Sandro Félix

Advances in Rheumatology

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2024, Volume 64 elocation 74

Resumo: En | Texto: En | PDF: En

Abstract Although the terms "rare diseases" (RD) and "orphan diseases" (OD) are often used interchangeably, specific nuances in definitions should be noted to avoid misconception. RD are characterized by a low prevalence within the population, whereas OD are those inadequately recognized or even neglected by the medical community and drug companies. Despite their rarity, as our ability on discovering novel clinical phenotypes and improving diagnostic tools expand, RD will continue posing a real challenge for rheumatologists. Over the last decade, there has been a growing interest on elucidating mechanisms of rare autoimmune and autoinflammatory rheumatic diseases, allowing a better understanding of the role played by immune dysregulation on granulomatous, histiocytic, and hypereosinophilic disorders, just to name a few. This initiative enabled the rise of innovative targeted therapies for rheumatic RD. In this review, we explore the state-of-the art of rare RD and the critical role played by rheumatologists in healthcare. We also describe the challenges rheumatologists may face in the coming decades. diseases (RD orphan (OD interchangeably misconception population companies rarity expand decade granulomatous histiocytic disorders few review stateofthe state healthcare decades

https://doi.org/10.1186/s42358-024-00407-6

Internações por condições sensíveis à atenção primária em crianças, Rondônia, Brasil, 2008-2019 crianças Rondônia Brasil 20082019 2008 2019 2008-201 2008201 200 201 2008-20 200820 20 2008-2 20082 2 2008-
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Santos, Adria da Silva

; Castro, Lorena Rios

; Freitas, Jeanne Lúcia Gadelha

; Cavalcante, Daniela Ferreira Borba

; Pereira, Priscilla Perez da Silva

; Oliveira, Tatiana Michelle Catão de

; Alves, Jéssica Cunha

Ciência & Saúde Coletiva

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Abr 2023, Volume 28 Nº 4 Páginas 1003 - 1010

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivou-se caracterizar o perfil de internações de crianças na rede pública dos 52 municípios do estado de Rondônia, Brasil, no período de 2008 a 2019. Trata-se de um estudo de série temporal do tipo ecológico, com dados secundários do Sistema de Informações Hospitalares. A tendência anual das internações foi apresentada por faixa etária e regional de saúde. Foi realizada regressão linear aplicando a técnica de Prais-Winsten no pacote estatístico Stata, versão 11.0. As internações por doenças gastrointestinais tiveram declínio em todas as faixas etárias, assim como pelas doenças previníveis por imunizantes entre 1 a 9 anos. As internações por doenças de pele e tecido subcutâneo foram crescentes em todas as idades, as epilepsias em idades de 1 a 9 anos e pelas doenças relacionadas ao parto e puerpério foi crescente. As regiões de saúde apresentaram perfil de internações variável, com tendência estável nas regiões Cone Sul, Madeira-Mamoré, Café, Vale do Guaporé, Vale do Jamari; e em declínio nas regiões Central e Zona da Mata. As elevadas taxas de internações por condições sensíveis à atenção primária em crianças refletem a pouca efetividade das estratégias e dos investimentos na esfera da atenção primária no estado. Objetivouse Objetivou se 5 Rondônia Brasil 200 2019 Tratase Trata ecológico Hospitalares PraisWinsten Prais Winsten Stata 110 11 0 11.0 etárias crescente variável Sul MadeiraMamoré, MadeiraMamoré Madeira Mamoré, Mamoré Madeira-Mamoré Café Guaporé Jamari Mata 20 201 11. 2

Abstract This study aimed to define the profile of hospitalizations of children in public hospitals of 52 municipalities of the state of Rondônia, Brazil. We performed an ecological time series study using secondary data provided by the Hospital Information System. The annual trend of Hospitalizations was presented by age group and health region. Linear regression was performed using the Prais-Winsten technique of the statistical package Stata, version 11.0. Hospitalizations for gastrointestinal diseases were found to be decreasing in all age groups, just as those for vaccine-preventable diseases in children aged between 1 and 9 years. Hospitalizations for skin and subcutaneous tissue diseases were increasing in all ages, as well as those caused by epilepsies in children aged 1 to 9 and those caused by diseases related to childbirth and puerperium. Health regions showed a varied hospitalization profile. A stable trend was found in the Cone Sul, Madeira-Mamoré, Café, Vale do Guaporé, and Vale do Jamari regions, whereas a declining trend was found in the Central and Zona da Mata regions. The high rates of hospitalizations for ambulatory care-sensitive conditions in children show how inefficient strategies and investments in primary care have been in the state of Acre, Brazil. 5 Rondônia Brazil System region PraisWinsten Prais Winsten Stata 110 11 0 11.0 groups vaccinepreventable vaccine preventable years ages puerperium Sul MadeiraMamoré, MadeiraMamoré Madeira Mamoré, Mamoré Madeira-Mamoré Café Guaporé caresensitive sensitive Acre 11.

https://doi.org/10.1590/1413-81232023284.07902022

Ansiedad y depresión en estudiantes de medicina de Latinoamérica durante la pandemia del COVID-19
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Aveiro-Róbalo, Telmo Raúl

; Garlisi-Torales, Luciana Daniela

; Nati-Castillo, Humberto Alejandro

; Valeriano-Paucar, Jhino Renson

; García-Arévalo, Carolina Michell

; Ayala-Servín, Nicolás

; Flores-Enriquez, Jessica Fernanda

; Rios-González, Carlos Miguel

; Rodriguez-Morales, Alfonso J.

Revista de salud publica del Paraguay

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Abr 2023, Volume 13 Nº 1 Páginas 40 - 45

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Objectives: To determine the frequency of depression and anxiety among Latin American medical students during social distancing in the COVID-19 outbreak period. Methods: Observational, descriptive and cross-sectional design, the study included all Latin American medical students affiliated to the Federación Latinoamericana de Sociedades Científicas de Estudiantes de Medicina (FELSOCEM) selected through non-probabilistic convenience sampling who agreed to participate in the study. Data was collected through a questionnaire, consisting primarily of socio-demographic characteristics such as age, gender, marital status, and country of origin; as a second section, the Goldberg depression and anxiety test was applied, and an analysis was carried out by the nature of the variables. The research protocol was approved by an institutional ethics committee. Results: Of 1579 participating students, from 15 Latin American countries, 68.59% (1083) were women, 65.04% (1027) were between 20 and 24 years old, 95.63% (1510) were single, 23.18% (366) lived in Panama and 11.08% (175) in Chile. 87.14% (1376) have symptoms of anxiety, 66.88% (1056) have symptoms of depression and 64.34% (1016) have both symptoms. Conclusions: A high percentage of medical students in Latin American population suffered symptoms of anxiety and depression during the social distancing measures in the covid-19 outbreak period, data that must be taken into account for future mental health strategies.

RESUMEN Objetivos: Determinar la frecuencia de depresión y ansiedad en estudiantes de la carrera de medicina de Latinoamérica durante el distanciamiento social en el período de brote del COVID-19. Métodos: Diseño observacional, descriptivo y corte transversal, se incluyó en el estudio todos los estudiantes de medicina de Latinoamérica que se encuentren afiliados a la Federación Latinoamericana de Sociedades Científicas de Estudiantes de Medicina (FELSOCEM) seleccionados a través del muestreo no probabilístico por conveniencia que accedieron participar del estudio. Mediante un cuestionario se recopilaron datos, compuesto primeramente por características sociodemográficas como edad, género, estado civil y país de procedencia; como segunda sección, el instrumento estuvo compuesto por el test de depresión y ansiedad de Goldberg, se realizó un análisis en concordancia con la naturaleza de las variables. El protocolo de investigación fue aprobado por un comité de ética institucional. Resultados: De 1579 estudiantes participantes, de 15 países latinoamericanos, 68.59% (1083) fueron mujeres, 65.04% (1027) tenían entre 20 y 24 años, 95.63% (1510) eran solteros, 23.18% (366) vivían en Panamá y 11.08% (175) en Chile. El 87.14% (1,376) tienen síntomas de ansiedad, el 66.88% (1,056) tienen síntomas de depresión y el 64.34% (1,016) tienen ambos síntomas. Conclusiones: Un alto porcentaje de la población médico-estudiantil latinoamericana padecieron de síntomas de ansiedad y depresión durante las medidas de distanciamiento social en el periodo de brote del covid-19, dato que tiene que ser tomado en cuenta para futuras estrategias sobre salud mental.

https://doi.org/10.18004/rspp.2023.abril.06

Cross-cultural invariance of the Spanish version of the COVID-19 Assessment Scorecard to measure the perception of government actions against COVID-19 in Latin America Crosscultural Cross cultural COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Caycho-Rodríguez, Tomás

; Valencia, Pablo D.

; Ventura-León, José

; Carbajal-León, Carlos

; Vilca, Lindsey W.

; Reyes-Bossio, Mario

; Delgado-Campusano, Mariel

; Yupanqui-Lorenzo, Daniel E.

; Paredes-Angeles, Rubí

; Rojas-Jara, Claudio

; Gallegos, Miguel

; Cervigni, Mauricio

; Martino, Pablo

; Polanco-Carrasco, Roberto

; Palacios, Diego Alejandro

; Moreta-Herrera, Rodrigo

; Samaniego-Pinho, Antonio

; Rivera, Marlon Elías Lobos

; Figares, Andrés Buschiazzo

; Puerta-Cortés, Diana Ximena

; Corrales-Reyes, Ibraín Enrique

; Calderón, Raymundo

; Gallegos, Walter L. Arias

; Petzold, Olimpia

; Camargo, Andrés

; Torales, Julio

; Blanco, J. Arkangel Monge

; González, Pedronel

; Smith-Castro, Vanessa

; Rivera, Wendy Yamilet Matute

; Ferrufino-Borja, Daniela

; Ceballos-Vásquez, Paula

; Muñoz-del-Carpio-Toia, Agueda

; Palacios, Jorge

; Burgos-Videla, Carmen

; León, Ana María Eduviges Florez

; Vergara, Ibeth

; Vega, Diego

; Barria-Asenjo, Nicol A.

; Schulmeyer, Marion K.

; Rios, Hassell Tatiana Urrutia

; Lira, Arelly Esther Lira

Psicologia: Reflexão e Crítica

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2023, Volume 36 elocation 34

Resumo: En | Texto: En | PDF: En

Abstract Objectives The present study aimed to evaluate the measurement invariance of a general measure of the perception of governmental responses to COVID-|19 (COVID-SCORE-10) in the general population of 13 Latin American countries. Methods A total of 5780 individuals from 13 Latin American and Caribbean countries selected by non-probabilistic snowball sampling participated. A confirmatory factor analysis was performed and the alignment method was used to evaluate invariance. Additionally, a graded response model was used for the assessment of item characteristics. Results The results indicate that there is approximate measurement invariance of the COVID-SCORE-10 among the participating countries. Furthermore, IRT results suggest that the COVID-SCORE-10 measures with good psychometric ability a broad spectrum of the construct assessed, especially around average levels. Comparison of COVID-SCORE-10 scores indicated that participants from Cuba, Uruguay and El Salvador had the most positive perceptions of government actions to address the pandemic. Thus, the underlying construct of perception of government actions was equivalent in all countries. Conclusion The results show the importance of initially establishing the fundamental measurement properties and MI before inferring the cross-cultural universality of the construct to be measured. COVID|19 COVID19 COVID |19 19 COVID-|1 COVIDSCORE10 COVIDSCORE SCORE 10 (COVID-SCORE-10 1 578 nonprobabilistic non probabilistic participated Additionally characteristics COVID-SCORE-1 Furthermore assessed levels Cuba pandemic Thus crosscultural cross cultural measured COVID|1 COVID1 |1 COVID-| COVIDSCORE1 (COVID-SCORE-1 57 COVID-SCORE- COVID| | COVID- (COVID-SCORE- 5 COVID-SCORE (COVID-SCORE

https://doi.org/10.1186/s41155-023-00277-9

Acquired enamel pellicle protects gastroesophageal reflux disease patients against erosive tooth wear
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MARTINI, Tatiana

; RIOS, Daniela

; DIONIZIO, Aline

; CASSIANO, Luiza de Paula Silva

; SILVA, Cíntia Maria de Souza e

; TAIRA, Even Akemi

; VENTURA, Talita Mendes Oliveira

; CÂMARA, João Victor Frazão

; Araujo, Tamara Teodoro

; MAGALHÃES, Ana Carolina

; CARVALHO, Thiago Saads

; BAUMANN, Tommy

; LUSSI, Adrian

; OLIVEIRA, Ricardo Brandt de

; PALMA-DIBB, Regina Guenka

; BUZALAF, Marília Afonso Rabelo

Brazilian Oral Research

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2023, Volume 37 elocation e085

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to compare the protein profile of the acquired enamel pellicle (AEP) formed in vivo in patients with or without gastroesophageal reflux disease (GERD), and with or without erosive tooth wear (ETW). Twenty-four volunteers were divided into 3 groups: 1) GERD and ETW; 2) GERD without ETW; and 3) control (without GERD). The AEP formed 120 min after prophylaxis was collected from the lingual/palatal surfaces. The samples were subjected to mass spectrometry (nLC-ESI-MS/MS) and label-free quantification by Protein Lynx Global Service software. A total of 213 proteins were identified, or 119, 92 and 106 from each group, respectively. Group 2 showed a high number of phosphorylated and calcium-binding proteins. Twenty-three proteins were found in all the groups, including 14-3-3 protein zeta/delta and 1-phosphatidylinositol. Several intracellular proteins that join saliva after the exfoliation of oral mucosa cells might have the potential to bind hydroxyapatite, or participate in forming supramolecular aggregates that bind to precursor proteins in the AEP. Proteins might play a central role in protecting the dental surface against acid dissolution. (AEP GERD, , (GERD) ETW. ETW . (ETW) Twentyfour Twenty four groups 1 GERD. GERD) 12 lingualpalatal lingual palatal surfaces nLCESIMS/MS nLCESIMSMS nLC ESI MS/MS MS (nLC-ESI-MS/MS labelfree label free software 21 identified 119 9 10 group respectively calciumbinding calcium binding Twentythree three 1433 14 14-3- zetadelta zeta delta 1phosphatidylinositol. 1phosphatidylinositol phosphatidylinositol phosphatidylinositol. 1-phosphatidylinositol hydroxyapatite dissolution (GERD (ETW nLCESIMS MSMS 11 143 14-3 14-

https://doi.org/10.1590/1807-3107bor-2023.vol37.0085

10.

Internações por condições sensíveis à atenção primária em crianças, Rondônia, Brasil, 2008-2019
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Santos, Adria da Silva

; Castro, Lorena Rios

; Freitas, Jeanne Lúcia Gadelha

; Cavalcante, Daniela Ferreira Borba

; Pereira, Priscilla Perez da Silva

; Oliveira, Tatiana Michelle Catão de

; Alves, Jéssica Cunha

Ciência & Saúde Coletiva

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2023, Volume 28 Nº 4 Páginas 1003 - 1010

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232023284.07902022

11.

Governança da água em município de pequeno porte: análise baseada no sistema socioecológico e nos princípios de Ostrom
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Lima, Daniela de Freitas

; Araújo, Jabes Melquíades de

; Ribeiro, Márcia Maria Rios

Engenharia Sanitaria e Ambiental

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Out 2022, Volume 27 Nº 5 Páginas 919 - 928

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Nesta pesquisa, analisa-se a governança da água do reservatório responsável pelo abastecimento da área urbana de um município de pequeno porte: São Miguel (RN). Para tanto, utilizaram-se as técnicas de pesquisa análise documental e observação participante para investigar o sistema socioecológico no contexto de colapso de água que acomete o município e verificar o atendimento aos princípios institucionais de Ostrom para a governança da água nessa localidade. Constatou-se que a escassez de recurso hídrico é resultante de um sistema não sustentável, uma vez que o sistema de recurso possui uma realidade climática que não é bem administrada; parte das unidades de recurso enfrenta escassez prolongada; o sistema de governança possui atuação deficitária; e os atores sofrem os impactos negativos dessa performance por meio da falta de água. A governança dos recursos hídricos do reservatório principal para abastecimento urbano mostra-se fragilizada, mas tem obtido avanços a partir do processo de alocação negociada de água. As estruturas de análise aplicadas permitiram detectar a realidade da governança da água da área de estudo e demonstrar a necessidade de implementação de melhorias, entre quais está a atuação concreta e assertiva das organizações responsáveis direta ou indiretamente pela questão hídrica de São Miguel (RN).

Abstract This research analyzed the water governance in the reservoir responsible for supplying the urban area of a small municipality: São Miguel, Rio Grande do Norte, Brazil. In order to do so, document analysis and participant observation were performed to investigate the socioecological system in the context of water collapse that affects the city and to verify compliance with the Ostrom's institutional principles for the water governance in this locality. It was found that the scarcity of water resources is the result of an non-sustainable system which has a climate reality that is not well managed. Part of the resource units face prolonged shortage; the governance system has a deficient performance; and the actors suffer the negative impacts of this performance through the lack of water. Water governance resources in the main reservoir for urban supply is weakened, but advances have been made in the negotiated water allocation process. The outcomes allowed us to detect the reality of the water governance in the study area and demonstrate the need for improvements. Among them is the concrete and assertive performance of the organizations directly or indirectly responsible for the water issue of São Miguel, Rio Grande do Norte.

https://doi.org/10.1590/s1413-415220210307

12.

Frequency of anti-neutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus
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Santacruz-Sandoval, Evelyn

; Aragón, Cristian C.

; Nieto-Aristizábal, Ivana

; Ruiz-Ordoñez, Ingrid

; Quijano, Jhoan S.

; Ramírez-Castillo, Daniela

; Mondragón M, Karen

; Posso-Osorio, Iván

; Barrera, María Claudia

; Rios-Serna, Lady J.

; , Gabriel J.

Revista Colombiana de Reumatología

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Jun 2022, Volume 29 Nº 2 Páginas 107 - 112

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN Introducción: El lupus eritematoso sistémico (LES) es una enfermedad autoinmune sistémica. Los pacientes con LES muestran múltiples autoanticuerpos séricos, incluyendo los anticuerpos anticitoplasma de neutrófilo (ANCA, por sus siglas en inglés). Existen 2 técnicas principales para la detección de ANCA: inmunofluorescencia indirecta (IFI) y ensayo por inmunoadsorción ligado a enzimas (ELISA). En este estudio nuestro objetivo fue determinar la frecuencia y las asociaciones clínicas de los ANCA en pacientes con LES. Métodos: Realizamos un estudio transversal de 74 pacientes con LES en un hospital de alta complejidad de Colombia. La presencia de ANCA se evaluó por IFI, utilizando láminas con fijación de etanol, y con ELISA para determinar las especificidades para mieloperoxidasa (MPO)-ANCA y proteinasa 3 (PR3)-ANCA. Resultados: Fueron evaluados 74 pacientes con LES, 60 (81,1%) de ellos fueron positivos para ANCA. Por el contrario, solo un paciente mostró especificidad para PR3-ANCA por ELISA. La relación entre la positividad para ANCA por IFI y las características clínicas y serológicas fue estadísticamente significativa para compromiso renal (p = 0,0174) y para el índice de actividad de la enfermedad (Systemic Lupus Erythematosus Disease Activity Index [SLEDAI]) (p = 0,0308). Conclusiones: Los ANCA detectados mediante fijación con etanol por técnicas de IFI, son comunes en pacientes con LES. Sin embargo, la detección de especificidades para PR3 o MPO es rara; se destaca la importancia de la evaluación de estos autoanticuerpos mediante diferentes técnicas.

ABSTRACT Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Patients with SLE exhibit multiple serum autoantibodies, including anti-neutrophil cytoplasmic antibodies (ANCAs). There are two main techniques to detect ANCAs: indirect immunofluorescence (IIF) and enzyme-linked immunosorbent assay (ELISA). In this study, an attempt was made to determine the frequency and clinical associations of ANCAs in patients with SLE. Methods: A cross-sectional study was conducted in a tertiary care hospital in Colombia that included 74 patients with SLE. The presence of ANCAs was assessed using IIF with ethanol-fixed slides, and ELISA was used to detect antibody specificities for myeloperoxidase (MPO)-ANCA and proteinase 3 (PR3)-ANCA. Results: Of the 74 patients with SLE evaluated, 60 (81.1%) of them were ANCA-positive by IIF. By contrast, only one patient showed specificity for PR3-ANCA by ELISA. The relevance of ANCA positivity by IIF and clinical and serological features was significant for renal involvement (p = .0174), and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) (p = .0308). Conclusion: ANCAs are common in the serum of patients with SLE, as detected by ethanol-fixed slides with IIF staining. However, detection of specificity to PR3 and/or MPO is rare, thus highlighting the importance of detecting these autoantibodies by different techniques.

13.

Prácticas mortuorias y manipulación de los cuerpos. Primer análisis tafonómico del sitio Los Tres Cerros 1 (Entre Ríos, Argentina)
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Scabuzzo, Clara

; Raap, María Agustina Ramos van

; Lorenzo, Bianca Micaela Di

; Selan, Daniela

; Rios, María del Pilar

Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas

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2022, Volume 17 Nº 2 elocation e20210042

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract The aim of this work is to deepen the knowledge of the mortuary practices carried out at the Los Tres Cerros 1 site. We emphasize the processes related to the intentional manipulation of individuals. To accomplish this, we present the results from the analysis of the preservation of bone elements and cut marks. The studied samples come from Los Tres Cerros 1 archaeological site (Entre Ríos, Argentina) and are composed of bone elements corresponding to a minimum number of 35 individuals. The results obtained from the preservation indexes indicate a homogeneous anthropic disturbance of the mortuary space. Likewise, anthropic marks were observed in 6.68% of the analyzed bone elements. These marks were recorded in all burial modalities and in individuals of both sexes and different age groups. Lastly, the results are consistent with a great variability of body manipulation practices.

Resumen El objetivo de este trabajo es profundizar en el conocimiento de las prácticas mortuorias llevadas a cabo en el sitio Los Tres Cerros 1 (Entre Ríos, Argentina), haciendo énfasis en los procesos vinculados con la manipulación intencional de los individuos. Para cumplir con este objetivo, se exponen los resultados del análisis de la preservación de los elementos óseos y del relevamiento de huellas antrópicas. El conjunto bioarqueológico está conformado por los elementos óseos correspondientes a un número mínimo de 35 individuos, enterrados en diversas modalidades de inhumación. Los resultados obtenidos de la aplicación de diferentes índices de preservación mostraron que hubo una perturbación antrópica homogénea del espacio mortuorio. Asimismo, el relevamiento de marcas antrópicas indicó la presencia de huellas de corte en el 6,68% de los elementos óseos analizados. Las mismas se registraron en todos los tipos de entierro y en los individuos de ambos sexos y distintos grupos etarios. Asimismo, la localización, la frecuencia y las acciones inferidas para cada uno de los entierros e individuos que integran las inhumaciones evidenciaron que existió variabilidad en la forma de manipulación de los cuerpos.

https://doi.org/10.1590/2178-2547-bgoeldi-2021-0042

14.

S-PRG-based toothpastes compared to NaF toothpaste and NaF varnish on dentin permeability in vitro
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MOSQUIM, Victor

; ZABEU, Giovanna Speranza

; FORATORI-JUNIOR, Gerson Aparecido

; BORGES, Alessandra Buhler

; RIOS, Daniela

; MAGALHÃES, Ana Carolina

; WANG, Linda

Journal of Applied Oral Science

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2022, Volume 30 elocation e20220082

Resumo: En | Texto: En | PDF: En

Abstract Objectives To analyze the effect of 5 toothpastes containing different percentages of S-PRG fillers compared to NaF toothpaste and NaF varnish on the dentin hydraulic conductance (Lp). Methodology Dentin disks (1.0±0.2 mm thickness) were cut from third molars, and their Lp values were evaluated using Flodec. The specimens were allocated into 7 groups (n=8). The minimum (smear layer) and the maximum (after acid etching) Lp values were recorded. Lp was also assessed after treatment with either a 0wt.%, 1wt.%, 5wt.%, 20wt.%, or 30wt.% S-PRG toothpaste, a NaF toothpaste, or a NaF varnish. Toothpastes were applied by brushing for 15 s, allowing it to settle for 1 min, and rinsing with deionized water. The NaF varnish was applied for 4 min and was removed with a probe. Specimens were exposed to citric acid (6%, pH 2.1, 1 min) and their final Lp was recorded. The pH of all products was recorded (n=3) and specimens from each group were analyzed by Laser Scanning Confocal Microscopy (LSCM). Data were subjected to 2-way repeated measures ANOVA and post-hoc Bonferroni (a=0.05). Results The highest Lp reduction was noticed for the 5wt.% S-PRG toothpaste, NaF toothpaste, and NaF varnish. However, the toothpastes containing 5wt.%, 20wt.%, and 30wt.% of S-PRG were similar to all toothpastes but differed from the NaF varnish. After erosion, all groups retrieved their maximum Lp values, except for the NaF varnish. The LSCM evidenced deposits on the surface of specimens treated with 5%, 20%, and 30% S-PRG-based toothpastes and NaF toothpaste. Even more deposits were observed for the NaF varnish. After the erosive challenge, the deposits were diminished in all groups. Conclusion Toothpastes containing 5wt.%, 20wt.%, and 30wt.% of S-PRG fillers behaved similarly to a conventional NaF toothpaste, even after an erosive challenge. The NaF varnish promoted better reduction of the Lp, but its effect was also diminished after erosion.

https://doi.org/10.1590/1678-7757-2022-0082

15.

¿Movimientos involuntarios asociado a corrección por déficit de vitamina B12?: A propósito de un caso
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Bendezú-Barnuevo, Daniela

; Atamari-Anahui, Noé

; Ccorahua-Rios, Maycol Suker

; Vera-Monge, Víctor

Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo

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Abr 2021, Volume 14 Nº 2 Páginas 211 - 213

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Background: Vitamin B12 deficiency is a nutritional problem that can present with neurological and hematological manifestations. There are limited reports on the appearance of involuntary movements when initiating cyanocobalamin treatment. Case report: A 5-month-old infant presented vomiting, paleness, and diﬃculty holding his head. Among the examinations, pancytopenia and vitamin B12 deficiency were found in the patient and the mother. Treatment with folic acid and cyanocobalamin was administered; However, on the fourth day of treatment, she presented choreiform movements for which clonazepam was administered. The tomography and the electroencephalogram were normal. At follow-up, the platelet and leukocyte count improved and the movements gradually remitted. Conclusion: Little is reported about the occurrence of involuntary movements when vitamin B12 deficiency is corrected. Follow-up evaluation is important to avoid unnecessary overmedication.

RESUMEN Antecedentes: La deficiencia de vitamina B12 es un problema nutricional que puede cursar con manifestaciones neurológicas y hematológicas. Existen limitados reportes sobre la aparición de movimientos involuntarios al iniciar tratamiento con cianocobalamina. Descripción del caso: Lactante de 5 meses presentó vómitos, palidez y dificultad para sostener la cabeza. Dentro de los exámenes se encontró pancitopenia y déficit de vitamina B12 en el paciente y la madre. Se administró tratamiento con ácido fólico y cianocobalamina; sin embargo, al cuarto día de tratamiento presentó movimientos coreiformes por lo que se administró clonazepam. La tomografía y el electroencefalograma fueron normales. Al seguimiento el recuento de plaquetas y leucocitos mejoraron y los movimientos remitieron gradualmente. Conclusiones: La aparición de movimientos involuntarios cuando se realiza la corrección por déficit de vitamina B12 es poco reportado. La evaluación al seguimiento es importante para evitar la sobremedicación innecesaria.

https://doi.org/10.35434/rcmhnaaa.2021.142.1066

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