ABSTRACT BACKGROUND: Considering the ability of the health and self-management in diabetes questionnaire (HASMID-10) to verify the impact of self-management on diabetes, we highlight its relevance to scientific research and clinical applicability. However, to date, no study has been conducted to scientifically support its use in other languages. OBJECTIVE: To translate, cross-culturally adapt, and validate the HASMID-10 into the Brazilian Portuguese. DESIGN AND SETTING: A translation, cross-cultural adaptation, and validation study conducted at Ceuma University. METHODS: Study was conducted in accordance with the Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures and Consensus-based Standards for the Selection of Health Measurement Instruments. We included participants of both sexes diagnosed with diabetes, aged between 18 and 64 years, and without cognitive deficits or any other limitations that would prevent them from answering the questionnaire. We assessed participants using the problem areas in diabetes (PAID) scale and HASMID-10. We assessed reliability using a test-retest model with a 7-day interval between assessments. We used intraclass correlation coefficient (ICC), 95% confidence interval (CI), standard error of measurement (SEM), minimum detectable difference (MDD), Spearman correlation coefficient, and floor and ceiling effects. RESULTS: Sample comprised 116 participants, most of whom were women, overweight, non-practitioners of physical activity, and nonsmokers. We observed significant correlations (P = 0.006; rho = −0.256) between the HASMID-10 and PAID, adequate reliability (ICC = 0.780) and internal consistency (Cronbach's alpha = 0.796). No ceiling or floor effects were observed. CONCLUSION: HASMID-10 has adequate measurement properties and may be used for Brazilians. BACKGROUND selfmanagement self management HASMID10 HASMID 10 (HASMID-10 applicability However date languages OBJECTIVE translate crossculturally cross culturally adapt HASMID-1 Portuguese SETTING translation crosscultural cultural adaptation University METHODS CrossCultural Cross Cultural SelfReport Self Report Consensusbased Consensus based Instruments 1 6 years PAID (PAID HASMID10. 10. testretest test retest 7day day 7 assessments ICC, ICC , (ICC) 95 CI, CI (CI) SEM, SEM (SEM) MDD, MDD (MDD) RESULTS 11 women overweight nonpractitioners non practitioners activity nonsmokers P 0.006 0006 0 006 −0.256 0256 256 0.780 0780 780 Cronbachs Cronbach s 0.796. 0796 0.796 . 796 0.796) CONCLUSION Brazilians HASMID1 (HASMID-1 HASMID- 9 (CI (SEM (MDD 0.00 000 00 −0.25 025 25 0.78 078 78 079 0.79 79 (HASMID- 0.0 −0.2 02 2 0.7 07 (HASMID 0. −0. −0 −

Chagas disease is a tropical neglected disease that affects millions of people worldwide, still demanding a more effective and safer therapy, especially in its chronic phase which lacks a treatment that promotes substantial parasitological cure. The technical note of Romanha and collaborators published in 2010 aimed establish a guideline with the set of minimum criteria and decision gates for the development of new agents against Trypanosoma cruzi with the focus on developing new antichagasic drugs. In this sense, the present review aims to update this technical note, bringing the state of the art and new advances on this topic in recent years. worldwide therapy cure 201 drugs sense years 20 2

ABSTRACT The objective of this article is to describe the process of developing concepts by geographer Manuel Correia de Andrade. When dealing with the conception of the Northeast, he presented the division into three regions: the hot and humid forest zone, the hot and dry hinterland, subject to periodic droughts, and a transition zone, the wilderness. This is the foundation of the traditional duality, antagonistic but complementary: the Northeast of sugar cane and cattle, divided by the Northeast of small property and polyculture. These are the three regions whose name was consecrated by tradition and reiterated by science: the “extreme Northeast” of Gilberto Freyre and the “sacred kingdom” of Ariano Suassuna. Andrade zone hinterland droughts wilderness duality complementary cattle polyculture science extreme sacred kingdom Suassuna

RESUMO O objetivo deste artigo é descrever o processo de elaboração de conceitos pelo geógrafo Manuel Correia de Andrade. Ao tratar da concepção de Nordeste, foi apresentando a divisão em três regiões: a zona da mata quente e úmida, o sertão quente e seco, sujeito a secas periódicas, e uma zona de transição, o agreste. Este é o fundamento da dualidade tradicional, antagônica mas complementar: o Nordeste da cana-de-açúcar e o do gado, divididos pelo Nordeste da pequena propriedade e da policultura. Tais são as três regiões cujo nome foi consagrado pela tradição e reiterado pela ciência: o “extremo Nordeste” de Gilberto Freyre e o “reino sagrado” de Ariano Suassuna. Andrade úmida seco periódicas transição agreste tradicional complementar canadeaçúcar cana açúcar gado policultura ciência extremo reino sagrado Suassuna

ABSTRACT OBJECTIVE To compare the profile and prevalence of hospitalizations in Brazil based on estimates from the National Health Survey (PNS), 2013 and 2019. METHODS A cross-sectional study that used data from the 2013 PNS and the 2019 PNS. The outcome was having been hospitalized for 24 hours or more in the last 12 months. We calculated the proportion of the population in different categories of age group, presence or absence of chronic diseases, and perception of health status. We estimated the total number of hospitalizations and the proportion corresponding to each category of age group, chronic disease, and perceived health status. We calculated the prevalence of hospitalization according to geographic, socioeconomic, and health conditions. We compared the estimates of two editions of the PNS using Student’s t-test for independent samples. We considered significant differences when the p-value was less than 0.01. And finally, we compared hospitalization estimates with administrative data to assess data consistency. RESULTS We observed that the proportion of chronically ill people in the population increased from 15.04% to 31.48%. This group was responsible for 36.76% of the total number of hospitalizations in 2013 and 57.61% in 2019. The prevalence of hospitalizations increased significantly between the two surveys and the increases were higher in the Southeast region and among people who have private health insurance. A discrepancy was found between administrative data and survey estimates. Obstetric hospitalizations and health insurance hospitalizations were underestimated. CONCLUSION There was an increase in overall hospitalization rates in the period between the PNS 2013 and PNS 2019, especially among people with better access to health services. The hospitalization profile also changed—in the 2013 PNS, hospitalizations of people without chronic diseases predominated. This was reversed in PNS 2019. , (PNS) 201 crosssectional cross sectional 2 1 months status disease geographic socioeconomic conditions Students Student s ttest t test samples pvalue p value 001 0 01 0.01 finally consistency 1504 15 04 15.04 3148 31 48 31.48% 3676 36 76 36.76 5761 57 61 57.61 underestimated services changedin changed predominated (PNS 20 00 0.0 150 15.0 314 3 4 31.48 367 7 36.7 576 5 6 57.6 0. 15. 31.4 36. 57. 31.

RESUMO OBJETIVO Comparar o perfil e a prevalência das hospitalizações no Brasil com base nas estimativas da Pesquisa Nacional de Saúde (PNS), 2013 e 2019. MÉTODOS Estudo transversal seriado que utilizou os dados das PNS 2013 e PNS 2019. O desfecho foi ter ficado internado por 24 horas ou mais nos últimos 12 meses. Calculamos a proporção da população nas diversas categorias de faixa etária, de presença ou ausência de doenças crônicas e de percepção do estado de saúde. Estimamos o número total de hospitalizações e a proporção correspondente a cada categoria de faixa etária, de doença crônica e de percepção do estado de saúde. Calculamos a prevalência de internação segundo fatores geográficos, socioeconômicos e condições de saúde. Comparamos as estimativas das duas edições da PNS utilizando o teste t de Student para amostras independentes. Consideramos as diferenças significativas quando o valor de p foi menor que 0,01. E finalmente comparamos as estimativas de hospitalização com os dados administrativos para avaliar a consistência dos dados. RESULTADOS Observamos que a proporção de doentes crônicos na população passou de 15,04% para 31,48%. Este grupo foi responsável por 36,76% do total de internações em 2013 e de 57,61% em 2019. A prevalência de hospitalizações aumentou significativamente entre os dois inquéritos e os incrementos foram maiores na região Sudeste e entre pessoas que possuem plano de saúde privado. Foi encontrada uma discrepância entre os dados administrativos e as estimativas dos inquéritos. As internações obstétricas e as internações por plano de saúde foram subestimadas. CONCLUSÃO Houve um aumento nas taxas globais de hospitalização no período compreendido entre as PNS 2013 e 2019, especialmente entre as pessoas com melhor acesso aos serviços de saúde. O perfil de hospitalização também mudou – na PNS 2013 predominaram internações de pessoas sem doenças crônicas. Isto se inverteu na PNS 2019. PNS, , (PNS) 201 2019 2 1 meses etária geográficos independentes 001 0 01 0,01 1504 15 04 15,04 3148 31 48 31,48% 3676 36 76 36,76 5761 57 61 57,61 privado subestimadas (PNS 20 00 0,0 150 15,0 314 3 4 31,48 367 7 36,7 576 5 6 57,6 0, 15, 31,4 36, 57, 31,

RESUMO OBJETIVO Comparar o perfil e a prevalência das hospitalizações no Brasil com base nas estimativas da Pesquisa Nacional de Saúde (PNS), 2013 e 2019. MÉTODOS Estudo transversal seriado que utilizou os dados das PNS 2013 e PNS 2019. O desfecho foi ter ficado internado por 24 horas ou mais nos últimos 12 meses. Calculamos a proporção da população nas diversas categorias de faixa etária, de presença ou ausência de doenças crônicas e de percepção do estado de saúde. Estimamos o número total de hospitalizações e a proporção correspondente a cada categoria de faixa etária, de doença crônica e de percepção do estado de saúde. Calculamos a prevalência de internação segundo fatores geográficos, socioeconômicos e condições de saúde. Comparamos as estimativas das duas edições da PNS utilizando o teste t de Student para amostras independentes. Consideramos as diferenças significativas quando o valor de p foi menor que 0,01. E finalmente comparamos as estimativas de hospitalização com os dados administrativos para avaliar a consistência dos dados. RESULTADOS Observamos que a proporção de doentes crônicos na população passou de 15,04% para 31,48%. Este grupo foi responsável por 36,76% do total de internações em 2013 e de 57,61% em 2019. A prevalência de hospitalizações aumentou significativamente entre os dois inquéritos e os incrementos foram maiores na região Sudeste e entre pessoas que possuem plano de saúde privado. Foi encontrada uma discrepância entre os dados administrativos e as estimativas dos inquéritos. As internações obstétricas e as internações por plano de saúde foram subestimadas. CONCLUSÃO Houve um aumento nas taxas globais de hospitalização no período compreendido entre as PNS 2013 e 2019, especialmente entre as pessoas com melhor acesso aos serviços de saúde. O perfil de hospitalização também mudou – na PNS 2013 predominaram internações de pessoas sem doenças crônicas. Isto se inverteu na PNS 2019.

ABSTRACT OBJECTIVE To compare the profile and prevalence of hospitalizations in Brazil based on estimates from the National Health Survey (PNS), 2013 and 2019. METHODS A cross-sectional study that used data from the 2013 PNS and the 2019 PNS. The outcome was having been hospitalized for 24 hours or more in the last 12 months. We calculated the proportion of the population in different categories of age group, presence or absence of chronic diseases, and perception of health status. We estimated the total number of hospitalizations and the proportion corresponding to each category of age group, chronic disease, and perceived health status. We calculated the prevalence of hospitalization according to geographic, socioeconomic, and health conditions. We compared the estimates of two editions of the PNS using Student’s t-test for independent samples. We considered significant differences when the p-value was less than 0.01. And finally, we compared hospitalization estimates with administrative data to assess data consistency. RESULTS We observed that the proportion of chronically ill people in the population increased from 15.04% to 31.48%. This group was responsible for 36.76% of the total number of hospitalizations in 2013 and 57.61% in 2019. The prevalence of hospitalizations increased significantly between the two surveys and the increases were higher in the Southeast region and among people who have private health insurance. A discrepancy was found between administrative data and survey estimates. Obstetric hospitalizations and health insurance hospitalizations were underestimated. CONCLUSION There was an increase in overall hospitalization rates in the period between the PNS 2013 and PNS 2019, especially among people with better access to health services. The hospitalization profile also changed—in the 2013 PNS, hospitalizations of people without chronic diseases predominated. This was reversed in PNS 2019.

Abstract Background Persistent headache attributed to past stroke (PHAPS) is a controversial entity, recently included in the third edition of the International Classification of Headache Disorders (ICHD-3) despite being described only in retrospective studies. Objective To determine the frequency and characteristics of PHAPS in patients admitted with acute stroke. Methods We selected all patients with headache associated with acute stroke (HAAS) from a prospective, single-center registry of patients with acute stroke admitted to a Neurology ward between November 2018 and December 2019. We analyzed demographic, clinical, and neuroimaging data. We assessed the follow-up with a phone call questionnaire at 6 to 12 months. Results Among 121 patients with acute stroke, only 29 (24.0%) had HAAS. From these, 6 (5.0%) were lost to follow-up. In total, 23 (20.0%) patients answered the 6- to 12-month follow-up questionnaire and were included in this study. The median age of the sample was 53 years (interquartile range [IQR]: 38–78 years), and there was no sex predominance. Of the 10 patients (8,3%) that had persistent headache, 8 (6.6%) suffered from previous chronic headaches; however, they all mentioned a different kind of headache, and 1 (0,8%) probably had headache secondary to medication. Conclusions In the present study, only 10 out of 121 stroke patients (8.3%) referred persistent headache at the 6- to 12-month follow-up, but the majority already suffered from previous chronic headache, which raises the question that the actual prevalence of PHAPS may be lower than previously reported. (PHAPS entity ICHD3 ICHD 3 (ICHD-3 studies HAAS (HAAS prospective singlecenter single center 201 2019 demographic clinical data followup follow up months 2 24.0% 240 24 0 (24.0% these 5.0% 50 5 (5.0% followup. up. total 20.0% 200 20 (20.0% 12month month study interquartile IQR [IQR] 3878 38 78 38–7 years, , years) predominance 8,3% 83 (8,3% 6.6% 66 (6.6% headaches however 0,8% 08 (0,8% medication 8.3% (8.3% followup, up, reported (ICHD- 24.0 (24.0 5.0 (5.0 20.0 (20.0 [IQR 387 7 38– 8,3 (8,3 6.6 (6.6 0,8 (0,8 8.3 (8.3 (ICHD 24. (24. 5. (5. 20. (20. 8, (8, 6. (6. 0, (0, 8. (8. (24 (5 (20 (8 (6 (0 (2 (

Resumo Antecedentes A cefaleia persistente atribuída a acidente vascular cerebral (AVC) prévio é uma entidade controversa, recentemente incluída na terceira edição da Classificação Internacional de Transtornos da Cefaleia (International Classification of Headache Disorders, ICHD-3), apesar de descrita apenas em estudos restrospectivos. Objetivo Determinar a frequência e as características do acidente vascular cerebral prèvio em doentes admitidos com AVC agudo. Métodos Selecionamos todos os doentes com cefaleia associada a AVC agudo de um registro unicêntrico e prospectivo de doentes admitidos no serviço de Neurologia entre novembro de 2018 e dezembro de 2019. Analisamos dados demográficos, clínicos e imagiológicos. Reavaliamos aos 6 a 12 meses por questionário telefónico. Resultados Entre os 121 doentes admitidos com AVC agudo, apenas 29 (24,0%) tinham cefaleia associada a AVC agudo. Destes, 6 (5,0%) perderam-se no seguimento. Ao todo, 23 (20,0%) responderam ao questionário e foram incluídos. A idade mediana foi de 53 anos (intervalo interquartílico [IIQ]: 38–78 anos), e não houve predominância de gênero. Dos 10 doentes (8,3%) que apresentam cefaleia persistente, 8 (6,6%) tinham histórico de cefaleia; no entanto todos mencionaram um tipo diferente de cefaleia, e 1 (0,8%) provavelmente tinha cefaleia secundária a medicação. Conclusões Neste estudo, apenas 10 em 121 doentes (8,3%) mencionaram cefaleia persistente aos 6 a 12 meses de seguimento, mas a maioria sofria de cefaleia prévia, pelo que a real prevalência de acidente vascular cerebral prèvio pode ser inferior à descrita nos estudos realizados até a data. (AVC controversa International Disorders ICHD3, ICHD3 ICHD 3 , ICHD-3) restrospectivos 201 2019 demográficos imagiológicos telefónico 2 24,0% 240 24 0 (24,0% Destes 5,0% 50 5 (5,0% perderamse perderam se seguimento todo 20,0% 200 20 (20,0% incluídos intervalo IIQ [IIQ] 3878 38 78 38–7 anos, anos) gênero 8,3% 83 (8,3% 6,6% 66 (6,6% 0,8% 08 (0,8% medicação estudo prévia data ICHD-3 24,0 (24,0 5,0 (5,0 20,0 (20,0 [IIQ 387 7 38– 8,3 (8,3 6,6 (6,6 0,8 (0,8 ICHD- 24, (24, 5, (5, 20, (20, 8, (8, 6, (6, 0, (0, (24 (5 (20 (8 (6 (0 (2 (

Resumo Desde o início da pandemia que, no contexto de Portugal Continental, a região do Alentejo se destacou pelo facto de ser aquela que apresenta o menor número de casos confirmados e de óbitos por Covid-19. Embora existam outros aspetos a considerar, a baixa densidade populacional que caracteriza o Alentejo será sempre um elemento chave para compreender a evolução da pandemia. Tomando este fenómeno eminentemente geográfico como pretexto, este artigo, que se desenrola em três momentos, começa por levar a cabo uma reflexão sobre os territórios de baixa densidade em Portugal Continental, para, depois, ensaiar uma aproximação ao modo como a Covid-19 se tem manifestado na região do Alentejo e, por fim, abordar a problemática do desenvolvimento futuro dos territórios de baixa densidade, tendo em conta o potencial que estes encerram.

Abstract Since the beginning of the pandemic, in the context of Mainland Portugal, the Alentejo region has stood out since it has the lowest number of confirmed cases and deaths by Covid-19. Although there are other aspects to consider, the low population density that characterizes Alentejo will always be a key element in understanding the evolution of the pandemic. Taking this eminently geographical phenomenon as a pretext, this article, which unfolds in three moments, begins by carrying out a reflection on the low-density territories in Mainland Portugal, and then rehearsing an approximation to the way in which Covid-19 has manifested itself in the Alentejo region and, finally, address the issue of the future development of low-density territories, taking into account the potential they contain.

RESUMO A classificação de Sapporo revisada para a síndrome antifosfolipídica definida de 2006 incluiu como critérios laboratoriais aqueles testes para anticorpos antifosfolípides cuja acurácia era considerada satisfatória de acordo com a evidência então disponível. Porém, na prática, a sensibilidade e especificidade desses anticorpos antifosfolípides “critério” são por vezes insuficientes para identificar ou descartar a síndrome antifosfolípide. Tem-se estudado se a acurácia do diagnóstico laboratorial da síndrome poderia ser melhorada por meio da testagem de anticorpos antifosfolípides não critério. Neste trabalho revisamos a evidência a respeito das associações clínicas e valor diagnóstico dos anticorpos não critério mais estudados, nomeadamente: anticorpos antifosfatidiletanolamina, antianexina A5, antiprotrombina, anticomplexo fosfatidilserina/protrombina, IgA anticardiolipina e IgG antidomínio I da anti-β2 glicoproteína I.

SUMMARY The 2006 Revised Sapporo Classification Criteria for Definite Antiphospholipid Syndrome included as laboratory criteria the tests for antiphospholipid antibodies whose accuracy was regarded as satisfactory according to the evidence available at that time. In practice, however, the sensitivity and specificity of these “criteria” of antiphospholipid antibodies are sometimes insufficient for identifying or ruling out antiphospholipid syndrome. It has been studied whether the accuracy of the laboratory diagnosis of the syndrome could be improved by testing for non-criteria antiphospholipid antibodies. In this work, we review evidence on the clinical associations and diagnostic value of the most commonly studied non-criteria antibodies, namely: antiphosphatidylethanolamine, anti-annexin A5, anti-prothrombin, anti-phosphatidylserine/prothrombin complex, IgA anticardiolipin, and IgG anti-domain I of the β2 glycoprotein antibodies.

ABSTRACT BACKGROUND: Self-Estimated Functional Inability because of Pain (SEFIP) is a questionnaire specifically designed to measure musculoskeletal pain or discomfort. OBJECTIVE: To perform translation and cross-cultural adaptation of the SEFIP for dancers (SEFIP-dance), for use in Brazilian Portuguese. In addition, as a secondary objective, we adapted the translated version of SEFIP-dance for use among athletes or exercise practitioners (SEFIP-sport). DESIGN AND SETTING: Questionnaire translation and cross-cultural adaptation study conducted at a public university. METHODS: The Brazilian version of the SEFIP-dance questionnaire was developed following the processes of translation (involving two translators with Brazilian Portuguese as their mother tongue and fluency in English), backtranslation (involving two translators with English as their mother tongue and fluency in Brazilian Portuguese), committee review and pre-testing. SEFIP-sport was developed following the processes of content and face validation. RESULTS: SEFIP-dance was applied to 30 dancers, of mean age 22.38 years (standard deviation [SD] = 3.41), among whom 14 were men (46.66%). The participants understood 100% of the SEFIP-dance items and alternatives. SEFIP-sport was applied to 30 athletes or physical exercise practitioners, of mean age 25.09 years (SD = 8.93), among whom 25 were men (86.33%). The participants understood 100% of the SEFIP-sport items and alternatives. CONCLUSION: The Brazilian Portuguese versions of SEFIP-dance, translated and cross-culturally adapted for dancers, and SEFIP-sport, adapted for athletes or physical exercise practitioners, were shown to have adequate levels of understanding.

Resumo Concluiu-se que, pela regra do fator previdenciário, as alíquotas vigentes são insuficientes para cobertura dos benefícios previdenciários, uma vez que as alíquotas atuarialmente justas são 30,69% e 35,27% para homens e mulheres, respectivamente. Contudo, caso a reforma da Previdência fosse aprovada em seu texto original, os percentuais justos seriam reduzidos para 22,25%, e 21,60%, respectivamente. Além da idade mínima, grande parte dessa redução deve-se às regras propostas para cálculo da pensão, que admitem valor abaixo do salário mínimo. Esses resultados atenderam ao objetivo deste trabalho, que foi comparar as alíquotas previdenciárias atuarialmente justas para o Regime Geral de Previdência Social, tendo como base as regras do fator previdenciário e da proposta de idade mínima, presente na Proposta de Emenda à Constituição n. 287/2016. As mudanças demográficas ocorridas no Brasil nos últimos anos chamam a atenção para a questão da sustentabilidade do sistema previdenciário nacional, e aprovar a reforma previdenciária tem sido prioridade do governo. Logo, é indiscutível a necessidade de um estudo atuarial que viesse calcular alíquotas atuarialmente justas e comparar o atual cenário com as propostas de reforma. Utilizaram-se modelos atuariais com múltiplos decrementos para o cálculo das alíquotas justas, considerando uma família padrão [funcionário(a) de 25 anos, cônjuge e dois filhos], sendo o homem três anos mais velho que a mulher. Adotaram-se como premissas biométricas as tábuas IBGE 2015 - Extrapolada (mortalidade) e Álvaro Vindas (invalidez), a taxa real de crescimento salarial de 2% a.a. e a taxa real de juros de 3% a.a.

Abstract It has been shown that under the social security factor rule current contribution rates are insufficient to cover social security benefits, since the actuarially fair rates are 30.69% and 35.27% for men and women, respectively. However, if the social security reform were approved as submitted, the fair rates would be reduced to 22.25% and 21.60%, respectively. Besides the minimum age, part of this reduction is due to the proposed rules allowing pension values lower than the minimum wage. These results served the objective of this work, which was to compare the actuarially fair social security rates for the General Social Welfare Policy (GSWP), based on the social security factor rules and the minimum age proposal present in Proposed Constitutional Amendment n. 287/2016. The demographic changes that have taken place in Brazil in recent years raise questions about the sustainability of the national social security system and approving social security reform has been a government priority. Therefore, there is an undisputed need for an actuarial study that calculates actuarially fair rates and compares the current scenario with the reform proposals. Multiple decrement actuarial models were used to calculate the fair rates considering a standard family (25-year-old worker, spouse, and two children), in which the man is three years older than the woman. The IBGE 2015 Extrapolated (mortality) and Álvaro Vindas (disability) tables were adopted as biometric assumptions, and a real wage growth rate of 2% p.a. and real interest rate of 3% p.a. were used.

Resumo A mais importante doença que ocorre em ipês é a ferrugem causada por fungos pertencentes ao gênero Prospodium, da ordem Pucciniales. O objetivo desse trabalho foi contribuir para o conhecimento das espécies de fungos que causam ferrugem em ipês apresentando a identificação e a descrição morfológica dos esporos de duas espécies do gênero Prospodium coletadas em Aquidauana-MS. As amostras de plantas com sintomas foram coletadas no campus da Universidade Estadual de Mato Grosso do Sul, Unidade Universitária de Aquidauana, região do ecótono Cerrado-Pantanal. Os esporos de Prospodium bicolor e P. tecomicola foram obtidos diretamente de folhas com sintomas de seus respectivos hospedeiros Handroanthus impetiginosus (ipê roxo) e H. vellosoi (ipê amarelo), e avaliados de acordo com seu estádio esporífero. Ambas as espécies de fungos causadores de ferrugem apresentaram mesósporos descritos aqui pela primeira vez para estas espécies. Este trabalho, representa o primeiro registro da ocorrência dessas ferrugens nas espécies hospedeiras de H. impetiginosus e H. vellosi no estado de Mato Grosso do Sul.

Abstract Rust is the most important disease that occurs in ipe trees, which is caused by fungi genera Prospodium, Order Pucciniales. The objective of this study was to contribute to the knowledge of species of fungi that cause ipês rust presenting spore identification and morphological description of two species of the genera Prospodium collected in Aquidauana-MS. Samples of plants with symptoms were collected at State University of Mato Grosso Do Sul in Aquidauana-MS, University Unit of Aquidauana, in region of the Cerrado-Pantanal ecotone. Spores of Prospodium bicolor and P. tecomicola were collected directly from leaves with symptoms of their respective hosts Handroanthus impetiginosus and H. vellosoi, and evaluated according to their spore states. Both species of fungi that caused rust presented mesospores, described for the first time on theses species. This work represents the first record of the occurrence of these rust in the host species of H. impetiginosus and H. vellosi in the state of Mato Grosso do Sul.

Abstract Jatropha curcas L. is a species with high potential for the biodiesel production. Therefore, the oil yield and quality from it seeds should be known. This study aimed to estimate the correlation between morphological traits, yield and oil quality evaluated in the seeds, to know the genetic diversity between J. curcas accessions and it behavior regarding to three harvest seasons. For this purpose, X-ray digital images from seeds of 18 accessions were obtained, and the seeds analyzed for external and internal morphological aspects. The same seeds were analyzed for oil yield and quality. In general, the results concerning diversity indicated a narrow genetic base. More rounded and very long seeds had lower oil yield. Larger seeds presented higher oil yield only when their internal cavity was filled by their endosperm. Most of the accessions showed variation regarding the size of the endosperm, yield and oil quality between harvest seasons.

ABSTRACT Objective assess the factors associated with inappropriate blood pressure in hypertensive patients monitored in the Family Health Strategy. Method cross-sectional study, involving 417 people in Maringá, Paraná. The data were collected in the first semester of 2016, using the instrument satisfaction of hypertensive users with Primary Health Care services; using the questions related to the sociodemographic, nutritional and clinical profile. In the data analysis, descriptive and inferential statistics were applied. Results most interviewees, 62.4% were elderly, 67.8% female and 55.2% retired/pensioner. Inappropriate blood pressure was associated with people over 59 years of age, retired/pensioners, moderately active, without practicing physical exercise and weakly oriented about the disease. Conclusion the results signal the need to reorganize the work process, strengthening the orientations and health education for arterial hypertension patients.

RESUMEN Objetivo El propósito del estudio fue evaluar los factores asociados a la presión arterial inadecuada en personas con hipertensión acompañadas por la Estrategia Salud de la Familia. Método Fue un estudio trasversal, realizado con 417 personas, en el municipio de Maringá, Paraná. La obtención de datos ocurrió en el primer semestre de 2016, por medio del instrumento de satisfacción del usuario con hipertensión arterial con los servicios prestados por la Atención Primaria a la Salud, utilizando las cuestiones referentes a los perfiles socio demográfico, nutricional y clínico. En el análisis de los datos, se aplicó estadística descriptiva e inferencial. Resultados La mayoría de los entrevistados, 62,4%, era de ancianos, 67,8% del sexo femenino y 55,2% jubilado/pensionado. Hubo asociación de la presión arterial inadecuada con edades superiores a 59 años, jubilados/pensionados, moderadamente activos, no practicantes de actividades físicas y la debilidad de orientaciones acerca de la enfermedad. Conclusión Se concluye que hay la necesidad de reorganizar el proceso de trabajo y perfeccionar las orientaciones y la educación en salud de las personas con hipertensión arterial.

RESUMO Objetivo avaliar os fatores associados à pressão arterial inadequada em pessoas com hipertensão acompanhadas pela Estratégia Saúde da Família. Método estudo transversal, realizado com 417 pessoas, no município de Maringá, Paraná. A coleta de dados foi realizada no primeiro semestre de 2016, por meio do instrumento satisfação do usuário com hipertensão arterial com os serviços prestados pela Atenção Primária à Saúde, utilizando as questões referentes ao perfil sociodemográfico, nutricional e clínico. Na análise dos dados, aplicou-se estatística descritiva e inferencial. Resultados a maioria dos entrevistados, 62,4% era idoso, 67,8% do sexo feminino e 55,2% aposentado/pensionista. Houve associação da pressão arterial inadequada com pessoas de idade superior a 59 anos, aposentados/pensionistas, moderadamente ativos, não praticantes de atividades físicas e fragilidade nas orientações sobre a doença. Conclusão os resultados sinalizam a necessidade de reorganização do processo de trabalho, com o fortalecimento das orientações e educação em saúde às pessoas com hipertensão arterial.

ABSTRACT Introduction: Schistosomiasis is an infectious parasitic disease caused by trematodes of the genus Schistosoma, which threatens at least 258 million people worldwide and its control is dependent on a single drug, praziquantel. The aim of this study was to evaluate the anti-Schistosoma mansoni activity in vitro of novel imidazolidine derivatives. Material and methods: We synthesized two novel imidazolidine derivatives: (LPSF/PTS10) (Z)-1-(2-chloro-6-fluorobenzyl)-4-(4-dimethylaminobenzylidene)-5-thioxoimidazolidin-2-one and (LPSF/PTS23) (Z)-1-(2-chloro-6-fluoro-benzyl)-5-thioxo-4-(2,4,6-trimethoxy-benzylidene)-imidazolidin-2-one. The structures of two compounds were determined by spectroscopic methods. During the biological assays, parameters such as motility, oviposition, mortality and analysis by Scanning Electron Microscopy were performed. Results: LPSF/PTS10 and LPSF/PTS23 were considered to be active in the separation of coupled pairs, mortality and to decrease the motor activity. In addition, LPSF/PTS23 induced ultrastructural alterations in worms, after 24 h of contact, causing extensive erosion over the entire body of the worms. Conclusion: The imidazolidine derivatives containing the trimetoxy and benzylidene halogens showed promising in vitro schistosomicidal activity.

RESUMO Os sertões foram conquistados e ocupados aos poucos, com base em um conhecimento dividido entre mito e realidade. Criou-se assim uma "geografia imaginária" sobre os sertões dos dois lados do Atlântico, que começou a ser superada com mais vigor no século XVIII. Até então, o interior do continente constituía um extenso vazio cartográfico que, a partir daí, começou a ser preenchido. Esse preenchimento somente foi possível, a exemplo do que ocorreu com a própria expansão pelos sertões, por uma estreita interpendência entre as ações da Coroa e as dos particulares.

ABSTRACT The sertões (backlands, hinterland) were conquered and occupied slowly, in a process characterized by the tension between myth and reality, which generated what we can designate as an "imaginary geography" in both sides of the Atlantic Ocean. This kind of geography, which lasted until the 18th Century, is marked by a cartographic vacuum in what refers to the backlands. This vacuum began to be fulfilled at that time, in a process that was made possible by the cooperation between Portuguese authorities and the sertanistas, as it was the case with territorial expansion itself.