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Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil LRV2 LRV (LRV2 (LRV
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Rêgo, Felipe Dutra

; da Silva, Eduardo Sérgio

; Lopes, Valeriana Valadares

; Teixeira-Neto, Rafael Gonçalves

; Belo, Vinícius Silva

; Fonseca Júnior, Antônio Augusto

; Pereira, Diego Andrade

; Pena, Heber Paulino

; Laurenti, Márcia Dalastra

; Araújo, Gabriela V

; da Matta, Vânia Lúcia Ribeiro

; Chouman, Islam Hussein

; Burrin, Thainá Bergantin

; Sandoval, Carmen M

; Barrouin-Melo, Stella Maria

; de Pinho, Flaviane Alves

; de Andrade, Hélida Monteiro

; Nunes, Ramon Vieira

; Gontijo, Célia Maria Ferreira

; Soccol, Vanete Thomaz

; Klocek, Donnamae

; Grybchuk, Danyil

; Macedo, Diego Henrique

; do Monte-Neto, Rubens Lima

; Yurchenko, Vyacheslav

; Soares, Rodrigo Pedro

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e230071

Resumo: En | Texto: En | PDF: En

BACKGROUND Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania. OBJECTIVES In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions. METHODS A total of seventy-one isolates were screened for LRV2 using semi-nested reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene. FINDINGS We detected LRV2 in two L. infantum isolates (CUR268 and HP-EMO) from canine and human cases, respectively. MAIN CONCLUSIONS To the best of our knowledge, this is the first detection of LRV2 in the New World. LRV1 LRV (LRV1 Viannia (LRV2 OldWorld Old World study L (L. VL, VL , (VL) hosts forms regions seventyone seventy one seminested semi nested transcriptionpolymerase transcription RTPCR RT PCR (RT-PCR RNAdependent dependent RdRp (RdRp gene CUR268 CUR (CUR26 HPEMO HP EMO HP-EMO cases respectively knowledge (LRV (L (VL CUR26 (CUR2 CUR2 (CUR

https://doi.org/10.1590/0074-02760230071

Comparative effects of fractional radiofrequency and microneedling on the genitalia of postmenopausal women: Histological and clinical changes
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Maia, Rafaella Rêgo

; Sarmento, Ayane Cristine

; Silva, Rodrigo Marcel Valentim da

; Carreiro, Eneida de Morais

; Farias, Stephany Luanna Queiroga

; Soares, Ciro Dantas

; Meyer, Patrícia Froes

; Gonçalves, Ana Katherine

Clinics

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2022, Volume 77 elocation 100117

Resumo: En | Texto: En | PDF: En

Abstract Objectives: The authors aimed to evaluate clinical and histological changes induced by Fractional Radiofrequency (FRF) and microneedling in vulvar tissue. Methods: Thirty postmenopausal women were randomly divided into G1 (FRF) and G2 (microneedling) groups. Sub-ablative FRF was executed using disposable fractionated electrodes with an intensity of 8 mJ. Microneedling was performed using a derma roller system. The authors evaluated before and after treatment using the Vaginal Laxity Questionnaire (VLQ), EuroQol Five-Dimensional (EQ-5D) questionnaire, and the Blatt and Kupperman Menopausal Index (BKMI). Additionally, the authors performed biopsies of the labia majora for histological analysis pre- and post-treatment. Data were expressed as mean (± standard deviation). A paired t-test was used for intra-group comparison (pre- and post-treatment), with an independent t-test used to compare intergroup data (both pre- and post-treatment). Results: In the G1 group, the VLQ values showed differences compared to the pre-treatment values with the data obtained 60 days after the beginning of the sessions (p = 0.01). Similarly, the data changes of the G2 group proved to be significant (p = 0.001) across the same time interval. In comparing the groups, VLQ values were not different (p > 0.05). Regarding histological analysis, FRF demonstrated improvement concerning the number of fibroblasts, blood vessels, and fatty degeneration (p < 0.05) compared to the control. Additionally, FRF and microneedling samples showed higher type III collagen and vimentin expression in the immunohistochemical analysis (p < 0.05). Conclusions: The therapies were found to be effective in treating the flaccidity of the female external genitalia. Additionally, histological changes were observed after interventions suggesting collagen remodeling.

https://doi.org/10.1016/j.clinsp.2022.100117

Analysis of GLT6D1 and CDKN2BAS gene polymorphisms in Brazilian patients with advanced periodontitis
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RODRIGUES, Richelle Soares

; RÊGO, Rodrigo

; CAMINAGA, Raquel Mantuaneli Scarel

; GOVEIA, Jéssica Marina

; SILVEIRA, Virginia Régia Souza

Brazilian Oral Research

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2022, Volume 36 elocation e077

Resumo: En | Texto: En | PDF: En

Abstract Gene polymorphisms can predispose to periodontal disease, as demonstrated by the well-documented association between aggressive periodontitis and single nucleotide polymorphisms (SNPs) such as rs153745 in the GLT6D1 gene and rs3217992 in the CDKN2BAS gene. The purpose of this study was to evaluate the presence of these SNPs in Brazilian patients with advanced periodontitis (stages III/IV, Grade B/C) vs. healthy controls. A total of 100 patients with periodontitis (Group BC) were enrolled. Of these, 51 patients were classified as stage III and 49 patients were classified as stage IV, and 52 were Grade B (Group B) and 48 were Grade C (Group C). The control Group consisted of 61 healthy subjects. DNA samples extracted from buccal epithelial cells were used to genotype the SNPs rs1537415 (GLT6D1) and rs3217992 (CDKN2BAS) by real-time quantitative PCR. No significant differences in polymorphism frequency were found between the control Group and each of the patient groups (BC, B, or C), and Group B did not differ from Group C. In conclusion, the evaluated SNPs had no significant influence on the prevalence of periodontal disease in the sampled Brazilian population.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0077

Teaching of ethics in medical undergraduate programs
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Alvares Lavigne de Lemos Tavares, Ana Carolina

; Alvares Travassos, Ana Gabriela

; da Silveira Tavares, Rodrigo

; Melo Pojal da Silva Rêgo, Maria Francisca

; Lopes Nunes, Rui Manuel

Acta bioethica

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Jun 2021, Volume 27 Nº 1 Páginas 101 - 117

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract 19. Literature points to the existent diversity in medical graduate courses’ curriculums, reinforcing the need to systematise and deepen more studies in this area with the aim of qualifying the formation of our future professionals. This study aims to understand the methods used in the teaching of Bioethics in medical graduation worldwide. It was characterised as an integrative review and the databases used were Pubmed, Scopus and Web of Science. In total 2993 articles were identified and 72 met the pre-selected criteria and were included in the review. The characteristics of teaching bioethics that stood out the most in the analysis were: teaching still very heterogeneous between different universities, use of various methodologies in the process of teaching/learning, teaching disconnected from the medical practice of students showing the need to integrate the curriculum with clinical practice and challenges of teaching-learning process. Most of the studies in this review lead us to understand that there is still no minimum parameters on the ideal method to teach bioethics, suggesting that it may affect the feeling of unpreparedness felt by students in face of ethical issues in clinical practice, despite the theoretical basis acquired.

Resumen 23. La literatura apunta a la diversidad existente en los currículos de los posgrados de medicina, reforzando la necesidad de sistematizar y profundizar más estudios en esta área, con el fin de capacitar la formación de nuestros futuros profesionales. Este estudio tiene como objetivo comprender los métodos utilizados en la enseñanza de la bioética en la graduación médica en el mundo. Se caracterizó como una revisión integradora y las bases de datos utilizadas fueron Pubmed, Scopus y Web of Science. En total se identificaron 2.993 artículos, 72 cumplieron los criterios preseleccionados y se incluyeron en la revisión. Las características de la enseñanza de la bioética que más se destacaron en el análisis fueron: docencia aún muy heterogénea entre diferentes universidades, uso de diversas metodologías en el proceso de enseñanza/aprendizaje, docencia desconectada de la práctica médica de los estudiantes, mostrando la necesidad de integrar el currículo con la práctica clínica y los desafíos del proceso de enseñanza/aprendizaje. La mayoría de los estudios de esta revisión nos lleva a entender que aún no existen parámetros mínimos sobre el método ideal para enseñar bioética, sugiriendo que puede impactar en la falta de preparación que sienten los estudiantes ante cuestiones éticas en la práctica clínica, a pesar de las teorías base adquiridas.

Resumo: 27. Vários estudos relatam a diversidade existente nos currículos da graduação em medicina, reforçando a necessidade de sistematizar e aprofundar mais estudos nesta área com o objetivo de qualificar a formação dos nossos futuros profissionais. Este estudo tem como objetivo compreender os métodos utilizados no ensino da Bioética na graduação em medicina em todo o mundo. Esse estudo caracterizou-se como revisão integrativa e as bases de dados utilizadas foram Pubmed, Scopus e Web of Science. No total, foram identificados 2.993 artigos e 72 atenderam aos critérios pré-selecionados e foram incluídos na revisão. As características do ensino da bioética que mais se destacaram nas análises foram: ensino ainda muito heterogêneo entre as diferentes universidades, utilização de diversas metodologias no processo de ensino / aprendizagem, ensino desvinculado da prática médica dos alunos evidenciando a necessidade de integração curricular com a prática clínica e os desafios do processo ensino-aprendizagem. A maioria dos estudos desta revisão nos leva a entender que ainda não existem parâmetros mínimos sobre o método ideal de ensino da bioética e traz como um desafio importante o despreparo sentido pelos alunos frente às questões éticas na prática, apesar da fundamentação teórica adquirida.

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Lutzomyia longipalpis: an update on this sand fly vector
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RÊGO, FELIPE D.

; SOARES, RODRIGO PEDRO

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 3 elocation e20200254

Resumo: En | Texto: En | PDF: En

Abstract Lutzomyia longipalpis is the most important vector of Leishmania infantum, the etiological agent of visceral leishmaniasis (VL) in the New World. It is a permissive vector susceptible to infection with several Leishmania species. One of the advantages that favors the study of this sand fly is the possibility of colonization in the laboratory. For this reason, several researchers around the world use this species as a model for different subjects including biology, insecticides testing, host-parasite interaction, physiology, genetics, proteomics, molecular biology, and saliva among others. In 2003, we published our first review (Soares & Turco 2003) on this vector covering several aspects of Lu. longipalpis. This current review summarizes what has been published between 2003-2020. During this period, modern approaches were incorporated following the development of more advanced and sensitive techniques to assess this sand fly.

https://doi.org/10.1590/0001-3765202120200254 397 downloads

Selection in segregating populations of ornamental pepper plants (Capsicum annuum L.) using multidimensional scaling
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Costa, Maria do Perpetuo Socorro Damasceno

; Rêgo, Elizanilda Ramalho do

; Barroso, Priscila Alves

; Silva, Anderson Rodrigo da

; Rêgo, Mailson Monteiro do

Revista Ceres

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Dez 2020, Volume 67 Nº 6 Páginas 474 - 481

Resumo: En | Texto: En | PDF: En

ABSTRACT Multidimensional scaling is a multivariate analysis technique that can be used to exploit genetic diversity, aiming at the selection of Capsicum genotypes with desirable characteristics for in-pot ornamental purposes. This work aimed to select genotypes with ornamental potential within F4 populations of ornamental pepper plants. Three F4 families were used (17.18, 30.16, and 56.8). The genotype distance matrices were estimated based on qualitative and quantitative descriptors, separately, combining the standardized distances of Gower and Mahalanobis, respectively. The relation of the distance between genotypes was graphically studied through non-metric multidimensional scaling. Kruskal' Stress was used as the measured misadjustment of the nMDS solution. There is genetic diversity within the analyzed families, allowing to practice selection. The selection in family 17.18 of genotypes 6 and 32 is recommended, as well as in family 30.16 of genotypes 22 and 4, and family 56.8 of genotypes 15 and 36, since they present important characteristics for ornamental purposes. The selection of genotypes is more efficient when using mixed data since it provides a more complete genetic diversity in an improvement program.

https://doi.org/10.1590/0034-737x202067060007 539 downloads

Prevalence of dengue, Zika and chikungunya viruses in Aedes (Stegomyia) aegypti (Diptera: Culicidae) in a medium-sized city, Amazon, Brazil
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Monteiro, Fred Júlio Costa

; Mourão, Fábio Rodrigo Paixão

; Ribeiro, Edicelha Soares D’Athaide

; Rêgo, Marlisson Octávio da Silva

; Frances, Pablo Abdon da Costa

; Souto, Raimundo Nonato Picanço

; Façanha, Marlucia dos Santos

; Tahmasebi, Roozbeh

; Costa, Antônio Charlys da

Revista do Instituto de Medicina Tropical de São Paulo

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2020, Volume 62 elocation e10

Resumo: En | Texto: En | PDF: En

ABSTRACT Aedes aegypti is associated with epidemic diseases in Brazil, such as urban yellow fever, dengue, and more recently, chikungunya and Zika viruses infections. More information about Ae. aegypti infestation is fundamental to virological surveillance in order to ensure the effectiveness of control measures in use. Thus, the present study aims to identify and compare infestation and infectivity of Ae. aegypti females in Macapa city, Amapa State (Amazon region), Brazil, between the epidemiological weeks 2017/02 and 2018/20. A total number of 303 Ae. aegypti females were collected at 21 fixed collection points, 171 at the 10 collection points in the Marabaixo neighborhood and 132 at the 11 collection points in the Central neighborhood. Among the collected samples, only two were positive for dengue virus, with a 2.08% (2/96 pools) infectivity rate for Marabaixo. The difference between the medians of Ae. aegypti females captured in Central and Marabaixo sites was not statistically significant. The findings indicate similar mosquito infestation levels between the neighborhoods, and a low-level of mosquito infectivity, although dengue virus was found only in Marabaixo. Virological surveillance of Ae. aegypti was important to identify sites of infection and determine possible routes of transmission to enable health surveillance teams to adopt preventive strategies where infected mosquitoes are present and act faster.

https://doi.org/10.1590/s1678-9946202062010 1615 downloads

Genetic diversity in F3 population of ornamental peppers (Capsicum annuum L.)
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Pessoa, Angela Maria dos Santos

; Rêgo, Elizanilda Ramalho do

; Silva, Ana Paula Gomes da

; Mesquita, Júlio Carlos Polimeni de

; Silva, Anderson Rodrigo da

; Rêgo, Maílson Monteiro do

Revista Ceres

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Dez 2019, Volume 66 Nº 6 Páginas 442 - 450

Resumo: En | Texto: En | PDF: En

ABSTRACT Peppers belong to the Solanaceae family and present a wide genetic variability that may be accessed through phenotypic and genotypic traits. This work aimed to study the genetic divergence in an ornamental pepper F3 population by multivariate methods based on the individual and simultaneous analyses of qualitative, quantitative, and molecular data. The work was developed in the Center of Agrarian Sciences (CCA) of the Universidade Federal da Paraíba (UFPB), Paraíba state, Brazil. 44 progenies from an F3 generation were used and the characterization of 30 qualitative traits, 16 quantitative traits, and 18 pairs of microsatellite primers was performed. Individual and simultaneous analyses of the variables were performed by using the clustering method of Ward’s algorithm. Tocher’s method was used based on distance matrixes. A non-metric multidimensional scaling was applied (nMDS) for the graphic representation of the distance matrixes in the bidimensional space. Data analysis was efficient to separate the genotypes into distinct groups. There is genetic variability among the individuals of the C. annuum F3 population, verified by individual and joint trait measurements. The three clustering methods were efficient to represent the genetic distance between individuals of ornamental pepper plants. Individuals 1, 2, 7, 8, 10, 11, 21, 27, 29, 35, and 38 are indicated to advance generation and continue the breeding program.

https://doi.org/10.1590/0034-737x201966060005 936 downloads

10.

Infectious Prophylaxis with Intrawound Vancomycin Powder in Orthopedic Surgeries: Systematic Review with Meta-Analysis
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Sadigursky, David

; Sousa, Mariana Drummond

; Cajaíba, Yasmin Galvão Linhares

; Martins, Rodrigo Rêgo

; Lobão, Diogo Maciel Vieira

Revista Brasileira de Ortopedia

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Dez 2019, Volume 54 Nº 6 Páginas 617 - 626

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Apesar das diversas estratégias perioperatórias empregadas para diminuir a incidência de infecção no sítio cirúrgico (ISS), tais complicações ainda são frequentes, e representam um desafio para os ortopedistas. Por esse motivo, há uma necessidade permanente de buscar métodos cada vez mais eficazes de profilaxia anti-infecciosa, para que sejam reduzidas significativamente as taxas de morbidade pós-operatória, mortalidade, e os custos com os cuidados de saúde. Este estudo teve como objetivo avaliar a eficácia da profilaxia infecciosa com aplicação tópica de vancomicina em pó em cirurgias ortopédicas. Fez-se um estudo de revisão sistemática com metanálise, usando-se o Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols 2015 (PRISMA-P 2015). Fez-se uma busca abrangente na literatura por estudos controlados sobre as taxas de ISS com e sem o uso de vancomicina em pó na ferida. Entre os 412 títulos encontrados que preencheram os critérios, foram selecionados 7 estudos, 4 prospectivos e 3 retrospectivos, todos em cirurgia de coluna. A amostra total foi de 6.944 pacientes, que foram divididos em 2 grupos: controle (3.814 pacientes) e intervenção (3.130 pacientes). Observou-se que no grupo intervenção, no qual a vancomicina tópica foi aplicada, 64 (2,04%) pacientes desenvolveram ISS, e, no grupo controle 144 (3,75%) pacientes. Os resultados da metanálise demonstraram que o uso de vancomicina tem efeito protetor contra ISS em cirurgias de coluna, com risco relativo (RR) de 0,59, significância estatística, e intervalo de confiança de 95% (IC95%) entre 0,35-0,98. O uso da vancomicina em pó profilática, no leito da ferida, tem fator protetor contra ISS em cirurgias de coluna; entretanto, mais ensaios prospectivos randomizados são necessários para recomendar seu uso em cirurgias ortopédicas.

Abstract Despite many existing strategies used to reduce the rates of surgical site infection (SSI), these are still fairly frequent complications that pose a challenge for orthopedic surgeons. Therefore, the search for more effective methods of perioperative infection prophylaxis became a main subject of research, with the goal of decreasing postoperative morbidity, mortality, and costs. Thus, the present study sought to assess the effectiveness of intra-wound vancomycin powder in orthopedic surgery SSI prophylaxis. A systematic review and meta-analysis study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols 2015 (PRISMA-P 2015). A comprehensive literature search was performed to identify controlled studies on the rates of SSI with or without the local use of vancomycin powder. Exclusion and inclusion criteria were applied. A meta-analysis with random effects was performed. Out of 412 titles that met the criteria, 7 studies regarding spine surgery were included: 4 prospective and 3 retrospective studies. A total of 6,944 cases were identified, and they were divided into 2 groups: the control group (3,814 patients), to whom intrawound vancomycin was not administered, and the intervention group (3,130 patients), to who vancomycin was administered locally. We observed that 64 (2.04%) patients in the intervention group developed SSI, in contrast to 144 (3.75%) patients in the control group. The results of the meta-analysis showed that the local use of vancomycin powder had an statistically significant protective effect against SSI in cases of spine surgery, with a relative risk (RR) of 0.59 and a 95% confidence interval (95%CI) of 0.35-0.98. The use of prophylactic intrawound vancomycin powder has a protective effect against SSI in spine surgeries; however, further prospective trials are needed to endorse its use in orthopedic surgeries.

https://doi.org/10.1016/j.rbo.2017.12.003 872 downloads

11.

Correlation network analysis between phenotypic and genotypic traits of chili pepper
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Silva, Anderson Rodrigo da

; Rêgo, Elizanilda Ramalho do

; Pessoa, Angela Maria dos Santos

; Rêgo, Maílson Monteiro do

Pesquisa Agropecuária Brasileira

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Abr 2016, Volume 51 Nº 4 Páginas 372 - 377

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi construir redes ponderadas de correlação, para descobrir estruturas de correlação e padrões de ligação entre 28 caracteres morfoagronômicos de pimenteiras, relacionados à plântula, planta, inflorescência e fruto. Informações fenotípicas e genotípicas de 16 genótipos de Capsicum foram analisadas. Estruturas de correlação e padrões de ligação podem ser facilmente identificados nas matrizes por meio do algoritmo Fruchterman-Reingold, com as informações da rede de correlações. Ambos os tipos de correlação mostraram o mesmo padrão geral de ligação entre caracteres de frutos, com altos valores de herdabilidade no sentido amplo e grande aptidão desses genótipos para o melhoramento agronômico e ornamental. As dimensões das folhas estão correlacionadas ao grupo de caracteres de fruto. Redes de correlação de caracteres de pimenteiras podem aumentar a eficácia da seleção de genótipos, uma vez que tanto caracteres correlacionados quanto grupos podem ser identificados.

Abstract: The objective of this work was to build weighted correlation networks, in order to discover correlation structures and link patterns among 28 morphoagronomic traits of chili pepper related to seedling, plant, inflorescence, and fruit. Phenotypic and genotypic information of 16 Capsicum genotypes were analyzed. Correlation structures and link patterns can be easily identified in the matrices using the Fruchterman-Reingold algorithm with correlation network information. Both types of correlations showed the same general link pattern among fruit traits, with high broad-sense heritability values and high aptitude of the genotypes for agronomic and ornamental breeding. Leaf dimensions are correlated with a cluster of fruit traits. Correlation networks of chili pepper traits may increase the effectiveness of genotype selection, since both correlated traits and groups can be identified.

https://doi.org/10.1590/S0100-204X2016000400010 3350 downloads

12.

DO DIFFERENT WEIGHT TRAINING METHODS CHANGE THE APPETITE OF YOUNG ADULTS?
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Prazeres, Thaliane Mayara Pessôa dos

; Aniceto, Rodrigo Ramalho

; Barros, Tércio Araújo do Rêgo

; Lima, Fábio Fellipe Martins de

; Guerra, Ricardo Luís Fernandes

; Prado, Wagner Luiz do

Journal of Physical Education

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2016, Volume 27 elocation e2711

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

ABSTRACT Este estudo verificou os efeitos de diferentes métodos de treinamento com pesos (TP) sobre a sensação de apetite de homens treinados. Amostra foi composta por 10 homens, com idades entre 18 e 29 anos. Foram realizadas duas sessões experimentais com wash out de sete dias: no método circuito (MC) os exercícios foram realizados alternados por segmento em forma de estações, enquanto que durante o método tradicional (MT) os exercícios foram realizados em séries consecutivas. Ambos os métodos tiveram o mesmo trabalho total. A sensação de fome e perspectiva do consumo alimentar foram coletados nos momentos: basal, imediatamente após a sessão e 1hora. Foi identificada diferença apenas entre os momentos (p<0,05), não havendo diferença entre métodos ou efeito de interação (p>0,05). Assim, conclui-se que os métodos de TP não alteraram a sensação de fome e a perspectiva de consumo alimentar, porém nota-se que a magnitude de elevação foi maior no MT.

ABSTRACT This study assessed the effects of different weight training (WT) on appetite feeling in trained men. The sample consisted of 10 men aged between 18 to 29 years old. There were two experimental sessions with a wash out of seven days: in the circuit weight training (CWT), exercises were performed by alternating segment in stations, while during the traditional method (TM) exercises were performed in consecutive series. Both methods had the same total workload. The perception of hunger and perspective of food intake were measured in moments: at baseline, after exercise and 1 hour. Differences only in feelings of hunger among moment (p>0.05) were showed, and there were not differences between methods or effect of interaction (p>0.05). Thus, we concluded that both training methods are not altering the feeling of hunger or perspective of food intake, however the magnitude to raise is higher in TM.

https://doi.org/10.4025/jphyseduc.v27i1.2711 2188 downloads

13.

Analysis of polymorphisms in Interleukin 10, NOS2A, and ESR2 genes in chronic and aggressive periodontitis
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SILVEIRA, Virginia Régia Souza

; PIGOSSI, Suzane Cristina

; SCAREL-CAMINAGA, Raquel Mantuaneli

; CIRELLI, Joni Augusto

; RÊGO, Rodrigo

; NOGUEIRA, Nádia Accioly Pinto

Brazilian Oral Research

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2016, Volume 30 Nº 1 elocation e105

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in the IL10, NOS2A, and ESR2 genes and chronic periodontitis (CP) and aggressive periodontitis (AgP). Three groups of patients underwent periodontal and radiographic evaluations: CP (n = 61), AgP (n = 50), and periodontally healthy (control group=61). Genomic DNA was extracted from oral epithelial cells and used for genotyping by real-time polymerase chain reaction using TaqMan® probes. The investigated SNPs were: -1087G > A, -819C > T and -592C > A in the IL10; +2087G > A in the NOS2A, and +1730G > A in the ESR2 gene. Differences in genotype and allele frequencies of each polymorphism and some individual characteristics were analyzed using the chi-square test and multivariate logistic regression analysis. Analysis of SNPs and haplotypes in the IL10 and SNP in the ESR2 gene did not present any significant association with AgP or CP. The +2087G allele of the NOS2A gene tended to be significantly associated with periodontal disease. Patients carrying the genotype +2087GG in the NOS2A gene were genetically protected against the development of CP (p = 0.05; OR = 0.44; 95%CI = 0.20–0.95). This result showed greater significance when patients with AgP and CP were combined (total PD) (p = 0.03; OR = 0.46; 95%CI = 0.23–0.92). In conclusion, the studied Brazilian population had a significantly higher frequency of the GG genotype for the +2087 SNP in the NOS2A gene in individuals without periodontitis, although statistical significance was not maintained after multiple logistic regression.

https://doi.org/10.1590/1807-3107BOR-2016.vol30.0105 1618 downloads

14.

Chenopodium ambrosioides L. extract prevents bone loss
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Soares, Ciro Dantas

; Carvalho, Maria Goretti Freire de

; Carvalho, Rejane Andrade de

; Trindade, Sérgio Rodrigo Pereira

; Rêgo, Amália Cinthia Meneses do

; Araújo-Filho, Irami

; Marques, Márcia Martins

Acta Cirúrgica Brasileira

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Dez 2015, Volume 30 Nº 12 Páginas 812 - 818

Resumo: En | Texto: En | PDF: En

ABSTRACT PURPOSE: To evaluate the effect of the Chenopodium ambrosioides L (mastruz) extract for preventing bone loss and bone metabolism in ovariectomized rats. METHODS: Twelve rats were subjected to bilateral ovariectomy for inducing osteoporosis. After surgery, they were divided into two groups: Ovariectomy-control group (G1, n=6), receiving 0.5 ml distilled water by gavage for 30 days, and Ovariectomy plus mastruz group (G2, n=6), receiving 0.5 ml of the hydroalcoholic extract of mastruz at 10% concentration (50mg) daily, for the same period. Then, the blood of the animals was collected for further biochemical analysis (liver function) and tibia and liver were removed for histological and histomorphometric analyses. RESULTS: The cortical bone was significantly larger in the G2 than G1, whereas G1 presented the highest amount of adipocytes in the bone marrow (p<0.05). The blood levels of aspartate aminotransferase, triglycerides and cholesterol were significantly higher, whereas globulin and lactate dehydrogenase were smaller in G2 than G1. CONCLUSION: The hydroalcoholic extract of mastruz has effects on bone metabolism by changing blood proteins and enzymes and preventing both bone loss and the substitution of bone marrow cells by

https://doi.org/10.1590/S0102-865020150120000004 2997 downloads

15.

Serum and liver lipids distributions in streptozotocin induced diabetic rat treated with diet containing Yam (Dioscorea bulbifera) flour
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Rozeno Pessoa, Letícia

; Rêgo, Thaís de Salgado

; Asht, Louise da Silva

; Monteiro, Igor Cabral Coutinho do Rêgo

; Soares Fortunato, Rodrigo

; Feijó, Márcia Barreto da Silva

; Correia-Santos, André Manoel

; Costa, Carlos Alberto Soares da

; Teles Boaventura, Gilson

Nutrición Hospitalaria

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Abr 2015, Volume 31 Nº 4 Páginas 1647 - 1653

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Introduction: Liver disease as a major cause of mortality in patients with diabetes mellitus. There is a interest to investigate the hypolipidemic properties of yam. The goal was assess the role of Brazilian yam (Dioscorea bulbifera) on serum and hepatic levels of triglycerides and cholesterol, in female diabetic rats. Methods: The rats were divided into three groups: Control (C), Diabetic (DM); Diabetic Yam (DMY), treated with diet containing 25g/100g of yam flour. After 5 weeks of experiment, glucose, insulin, gonadal fat and liver mass were evaluated. Serum and liver concentrations of triglycerides and cholesterol concentrations were quantified. Total liver thiols were determined. Results: After the 5 weeks, experimental groups shower (P < 0.05): Lower body mass; lower serum insulin; higher food intake and higher blood glucose concentration. DMY (vs. DM) group showed (P < 0.05): Lower blood glucose; higher gonadal fat mass; lower serum and hepatic triglycerides; higher hepatic cholesterol and thiols concentrations. DMY (vs. C) group showed: Similar serum and hepatic triglycerides and hepatic thiols. Conclusions: Brazilian yam (Dioscorea bulbifera) alleviated the consequences of the experimental diabetic disease, suggesting protection to hypertriglyceridemia and lipid peroxidation.

Introducción: La enfermedad hepática como una de las principales causas de mortalidad en los pacientes con diabetes mellitus. Hay un interés para investigar las propiedades hipolipemiantes de ñame. El objetivo era evaluar el papel de ñame brasileña (Dioscorea bulbifera) en suero y los niveles hepáticos de triglicéridos y colesterol, en las ratas diabéticas . Métodos: Las ratas se dividieron en tres grupos: control (C), diabéticos (DM); Diabetic ñame (DMA), se trata con dieta que contenía 25 g / 100 g de harina de ñame. Después de 5 semanas de experimento, la glucosa, la insulina, la grasa gonadal y la masa del hígado fueron evaluados. Se cuantificaron las concentraciones de suero e hígado de los triglicéridos y las concentraciones de colesterol. Se determinaron los tioles totales de hígado. Resultados: Después de las 5 semanas, experimental ducha grupos (p <0,05): la masa corporal inferior; insulina sérica inferior; más alta la ingesta de alimentos y una mayor concentración de glucosa en sangre. DMY (vs. DM) grupo mostró (P <0.05): Baje la glucosa en sangre; masa grasa gonadal superior; inferior y triglicéridos séricos hepáticas; más altos de colesterol y tioles concentraciones hepáticas. DMY (vs. C) grupo mostró: suero similares y triglicéridos hepáticos y tioles hepáticas. Conclusiones: Ñame brasileño (Dioscorea bulbifera) alivian las consecuencias de la enfermedad diabética experimental, lo que sugiere protección para la hipertrigliceridemia y la peroxidación lipídica.

https://doi.org/10.3305/nh.2015.31.4.8438 481 downloads

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