RESUMO Objetivo: Este estudo objetivou analisar a produção científica sobre polimorfismo genético e reabsorção radicular apical externa (external apical root resorption, EARR) para estabelecer os principais achados, tendências geográficas e lacunas de pesquisa, para possíveis investigações futuras. Métodos: Foram pesquisadas publicações na base de dados Scopus (março de 2023) para incluir estudos que abordassem a associação entre polimorfismos genéticos e EARR. Foram considerados elegíveis estudos de caso-controle, relatos de caso, coorte, transversais e revisões. Para análise dos dados, foram utilizados os softwares VOS viewer® e Bibliometrix. Resultados: Dos 44 estudos incluídos, Iglesias-Linares A foi o autor mais citado. A Universidade de Sevilha (Espanha) foi a instituição que mais pesquisou o tema. Brasil, Espanha e EUA foram os principais países em termos de citações. O termo mais frequente na coocorrência das palavras-chave foi EARR. O periódico American Journal of Orthodontics and Dentofacial Orthopedics apresentou grande relevância na área, com vários artigos publicados. Vários polimorfismos genéticos foram investigados, sendo as interleucinas as mais estudadas. Conclusão: Endodontia é uma área de pesquisa que poderia focar mais no tema reabsorção radicular e polimorfismos genéticos, por ser um assunto ainda pouco explorado, em comparação à Ortodontia. Polimorfismos têm sido estudados como possíveis genes preditores de EARR como consequência da movimentação dentária ortodôntica. No entanto, ainda existe uma lacuna na investigação, indicando a necessidade de procurar novos genes associados à EARR. Objetivo external resorption achados futuras Métodos março 2023 casocontrole, casocontrole caso controle, controle caso-controle coorte revisões viewer Bibliometrix Resultados 4 incluídos IglesiasLinares Iglesias Linares citado (Espanha Brasil citações palavraschave palavras chave publicados investigados estudadas Conclusão explorado Ortodontia ortodôntica entanto investigação 202 20 2

ABSTRACT Objective: This study aimed to analyze the scientific production of genetic polymorphisms and external apical root resorption (EARR) to establish main findings, geographic trends, and research gaps for possible future investigations. Methods: Unrestricted publications were searched using the Scopus database (March 2023) to include studies that addressed the association between genetic polymorphisms and EARR. Case-control, cohort, cross-sectional, and review studies were considered eligible. The softwares VOS viewer™ and Bibliometrix were used for data analysis. Results: Of the 44 studies analyzed, “Iglesias-Linares A” was the most cited author. The University of Seville (Spain) conducted the most research on this topic. Brazil, Spain, and the USA were the leading countries in terms of citations. The most frequent term in the co-occurrence of keywords was “EARR.” The journal American Journal of Orthodontics and Dentofacial Orthopedics presented a great relevance in the area, demonstrating a high number of publications. Several genetic polymorphisms have been investigated, with interleukins being the most studied. Conclusion: Endodontics is an area of research that should focus more on root resorption and genetic polymorphisms, as it still underexplored, compared to orthodontics. Polymorphisms have been studied as possible predictors of EARR caused by orthodontic tooth movement. However, the gap in the research indicates a need to search for new genes associated with EARR. Objective (EARR findings trends investigations Methods March 2023 Casecontrol, Casecontrol Case control, control Case-control cohort crosssectional, crosssectional cross sectional, sectional cross-sectional eligible viewer analysis Results 4 analyzed IglesiasLinares Iglesias Linares A author Spain (Spain topic Brazil citations cooccurrence co occurrence “EARR. investigated Conclusion underexplored orthodontics movement However 202 “EARR 20 2

Abstract: This cross-sectional study aimed to assess if genetic polymorphisms in TNF- α are associated with a negative impact on Oral Health-Related Quality of Life (OHRQoL) in children with dental caries. A total of 307 pairs of parents/caregivers and children aged two to five years were selected. The children were clinically evaluated and classified according to caries experience and severity of active caries. The Brazilian Portuguese version of the Early Childhood Oral Health Impact Scale (ECOHIS) was used to assess OHRQoL. Genotyping analysis of genetic polymorphisms in TNF- α (rs1799724, rs1799964, and rs1800629) was performed using real-time polymerase chain reaction. In the recessive model, children with the CC genotype of TNF-α (rs1799964) had a significantly high chance of poor OHRQoL in the symptom domain (pain), in both the caries experience (p = 0.045) and the high-severity active caries phenotypes (p = 0.033) (Mann-Whitney U test). It was concluded that genetic polymorphisms in TNF-α are associated with OHRQoL related to the symptom domain (pain), suggesting that TNF-α could be used as a potential biomarker for OHRQoL. Understanding the genetic aspects associated with OHRQoL will allow the early identification of patients with OHRQoL disparities and provide personalized healthcare.