Abstract The present study aimed to investigate the prevalence of dissatisfaction with dental appearance among 24-year-old Brazilian adults and the associated factors in life course. A subsample (n = 720) of the 1982 Pelotas Birth Cohort in southern Brazil was investigated at the ages of 15 and 24 years using clinical (caries and periodontal) examinations and interviews. The outcome was dissatisfaction with dental appearance at the age of 24 years. Covariate variables included socioeconomic factors, oral health, and dissatisfaction with general appearance collected during different periods of life. Poisson regression models with robust variance were applied. The prevalence of dissatisfaction with dental appearance was 43.5% (95%CI: 39.8–47.1). Individuals with downward income mobility (PR = 1.22, 95%CI: 1.07–1.79) and those always poor (PR = 1.21, 95%CI: 1.00–1.57) presented a higher prevalence of dissatisfaction with their dental appearance even after oral health variables and dissatisfaction with general appearance were controlled for. Moderate/severe malocclusion at 15 years (PR = 1.34, 95%CI: 1.13–1.59), highest experience of untreated dental caries at 24 years (PR = 1.82, 95%CI: 1.46–2.27), and dental pain experience at 24 years (PR = 1.29, 95%CI: 1.22–1.75) were associated with the outcome. Also, the prevalence of dissatisfaction with dental appearance was 20% higher (PR = 1.20, 95%CI: 1.01–1.43) among those dissatisfied with their general appearance. Our findings demonstrated a high prevalence of dissatisfaction with dental appearance among young adults. Lifetime economic disadvantage and dental problems (malocclusion at 15 years, untreated dental caries at 24 years, and dental pain at 24 years) were associated with dissatisfaction with dental appearance among young adults. 24yearold yearold year old course n 720 198 1 2 periodontal interviews applied 435 43 5 43.5 95%CI 95CI CI 95 (95%CI 39.8–47.1. 398471 39.8–47.1 . 39 8 47 39.8–47.1) PR 122 22 1.22 1.07–1.79 107179 07 79 121 21 1.21 1.00–1.57 100157 00 57 for Moderatesevere Moderate severe 134 34 1.34 1.13–1.59, 113159 1.13–1.59 , 13 59 1.13–1.59) 182 82 1.82 1.46–2.27, 146227 1.46–2.27 46 27 1.46–2.27) 129 29 1.29 1.22–1.75 122175 75 Also 20 120 1.20 1.01–1.43 101143 01 72 19 4 43. 9 39847 39.8–47. 3 12 1.2 1.07–1.7 10717 0 7 1.00–1.5 10015 1.3 11315 1.13–1.5 18 1.8 14622 1.46–2.2 1.22–1.7 12217 1.01–1.4 10114 3984 39.8–47 1. 1.07–1. 1071 1.00–1. 1001 1131 1.13–1. 1462 1.46–2. 1.22–1. 1221 1.01–1. 1011 398 39.8–4 1.07–1 107 1.00–1 100 113 1.13–1 146 1.46–2 1.22–1 1.01–1 101 39.8– 1.07– 10 1.00– 11 1.13– 14 1.46– 1.22– 1.01– 39.8 1.07 1.00 1.13 1.46 1.01 39. 1.0 1.1 1.4

Abstract We present the first records of insect visitors and pollinators of Bertholletia excelsa (Lecythidaceae) in a 25 years plantation outside the Amazon biome, flowering and producing Brazil nuts. We installed a platform to observe and photograph the insects. The collected insects were stored, mounted, and identified by specialists. Six species were observed, three of them classified as potential pollinators (Centris lutea, Eulaema nigrita, Eulaema cingulata). The species E. nigrita and E. cingulata were already reported as a pollinators of Brazil nut in Amazon. This is the first record of C. lutea as potential pollinators for B. excelsa.

ABSTRACT OBJECTIVE To estimate the association between vitamin D and the cognitive decline of older adults and evaluate whether this association is mediated by brain-derived neurotrophic factor (BDNF) serum concentration. METHODS Cross-sectional study nested in a population-based cohort. Of the 604 participants in the complementary examination of the EpiFloripa Study, 576 older adults (60 years or older) were eligible for the study. The outcome is cognitive decline evaluated by the Mini-Mental State Examination, the exposure is vitamin D, and BDNF is the mediator. The control variables are age, sex, per capita family income, and educational level. The direct effect of vitamin D and BDNF on cognitive decline and the indirect effect mediated by BDNF was evaluated using path analysis, with the estimation of standardized coefficients. RESULTS Among the participants, we observed a direct and positive effect of vitamin D on cognitive function (Coef: 0.06; 95%CI: 0.02 to 0.11; p < 0.001) and serum BDNF concentration (Coef: 21.55; 95%CI: 9.92 to 33.17; p = 0.002), i.e., the higher the vitamin D, the higher the cognitive function and serum level of BDNF. CONCLUSION There was an association between vitamin D on serum BDNF and on cognitive decline in older adults. Moreover, BDNF did not have an effect on cognitive decline, so BDNF was not a mediator of the vitamin D effect on cognitive decline.

ABSTRACT OBJECTIVE To estimate the association between vitamin D and the cognitive decline of older adults and evaluate whether this association is mediated by brain-derived neurotrophic factor (BDNF) serum concentration. METHODS Cross-sectional study nested in a population-based cohort. Of the 604 participants in the complementary examination of the EpiFloripa Study, 576 older adults (60 years or older) were eligible for the study. The outcome is cognitive decline evaluated by the Mini-Mental State Examination, the exposure is vitamin D, and BDNF is the mediator. The control variables are age, sex, per capita family income, and educational level. The direct effect of vitamin D and BDNF on cognitive decline and the indirect effect mediated by BDNF was evaluated using path analysis, with the estimation of standardized coefficients. RESULTS Among the participants, we observed a direct and positive effect of vitamin D on cognitive function (Coef: 0.06; 95%CI: 0.02 to 0.11; p < 0.001) and serum BDNF concentration (Coef: 21.55; 95%CI: 9.92 to 33.17; p = 0.002), i.e., the higher the vitamin D, the higher the cognitive function and serum level of BDNF. CONCLUSION There was an association between vitamin D on serum BDNF and on cognitive decline in older adults. Moreover, BDNF did not have an effect on cognitive decline, so BDNF was not a mediator of the vitamin D effect on cognitive decline.

Abstract Purpose The authors aim to carry out an investigation on the impact of cervical oncogenic Human Papillomavirus (HPV) detection in pregnant adolescents, to clarify the prevalence and risk factors, considering the importance and lack of data on this topic in Brazil. Methods A cross-sectional study was conducted with adolescents receiving prenatal care in a tertiary hospital in São Paulo, Brazil, with routine Pap smear and oncogenic HPV detection test in the uterine cervix. The authors sought to associate the results of these tests with demographic and obstetric variables. Results A total of 303 pregnant adolescents whose mean age was 15.30 ± 1.22 years comprised the study subjects. The frequency of high-risk HPV cervical detection was 50.50%. Multivariate analysis revealed that a large number of partners in their lifetime (OR = 1.27) and having a religion (OR = 2.05) were risk factors for cervical detection of oncogenic HPV, while schooling appeared as a protective factor (OR = 0.85). There was an association between this detection and colpocytological alterations, reaching almost 30% of patients, but without association with obstetric and neonatal outcomes. Conclusion The prevalence found is one of the highest in Brazil and worldwide. A greater number of partners during their lifetime and having religion were detected as possible factors associated with cervical HPV detection. Detection of cervical HPV-DNA did not influence obstetric and neonatal outcomes. The findings of this study reinforce the need to implement educational measures capable of modifying the incidence of sexually transmitted infections in this population and capable of promoting adherence to HPV vaccination programs.

RESUMO OBJETIVO Estimar o efeito da idade, período e coorte de nascimento na mortalidade por câncer de boca e orofaringe no Brasil e suas macrorregiões. MÉTODO Foram analisados os óbitos por câncer de boca e orofaringe de 1983 a 2017. Aplicou-se o modelo de regressão de Poisson, utilizando funções estimáveis propostas por Holford. RESULTADOS No período de 1983 a 2017, foram registrados no Brasil 142.634 óbitos por câncer de boca e orofaringe, 81% entre o sexo masculino, e as regiões Sul e Sudeste apresentaram as taxas mais altas. Os maiores efeitos de período foram observados na mortalidade masculina das regiões Sudeste e Centro-Oeste para o período de referência 2003–2007. Nas regiões Norte, Nordeste e Centro-Oeste foi observado aumento do risco de mortalidade nas coortes masculinas mais recentes. Na região Norte o maior risco identificado foi para homens nascidos entre 1973 e 1977 (RR = 1,47; IC95% 1,05–2,08); no Nordeste, para homens nascidos entre 1988 e 1992 (RR = 2,77; IC95% 1,66–4,63); e no Centro-Oeste, para mulheres nascidas entre 1973 e 1977 (RR = 2,01; IC95% 1,19–3,39). Nas regiões Sudeste e Sul, as coortes mais recentes apresentaram taxas de mortalidade mais baixas. O menor risco na região Sudeste foi observado na coorte masculina nascida entre 1978 e 1982 (RR = 0,53; IC95% = 0,45–0,62), e entre 1983 e 1987 na região Sul (RR = 0,25; IC95% 0,12–0,54). CONCLUSÕES A idade teve efeito significativo na mortalidade por câncer de boca e orofaringe em todas as regiões. Nas regiões Norte, Nordeste e Centro-Oeste, foi observado aumento do risco nas coortes mais recentes, enquanto nas regiões Sul e Sudeste essas coortes apresentaram risco menor quando comparadas às coortes mais antigas.

ABSTRACT OBJECTIVE Estimate the effect of age, period, and birth cohort on mortality from oral and oropharyngeal cancer in Brazil and its macro-regions. METHODS Deaths from oral and oropharyngeal cancer from 1983 to 2017 were analyzed. The Poisson regression model was applied, using estimable functions proposed by Holford. RESULTS From 1983 to 2017, 142,634 deaths from oral and oropharyngeal cancer were registered in Brazil, 81% among men, and the South and Southeast regions had the highest rates. The most significant period effects were observed in male mortality in the Southeast and Central-West regions for the 2003–2007 reference period. In the North, Northeast, and Central-West regions, an increased risk of mortality was observed in the most recent male cohorts. In the North region, the most significant risk identified was for men born during 1973–1977 (RR = 1.47; 95%CI 1.05–2.08); in the Northeast, for men born during 1988–1992 (RR = 2.77; 95%CI 1.66–4.63); and in the Central-West, for women born during 1973–1977 (RR = 2.01; 95%CI 1.19–3.39). In the Southeast and South regions, the most recent cohorts had lower mortality rates. The lowest risk in the Southeast region was observed in the male cohort born during 1978–1982 (RR = 0.53; 95%CI 0.45–0.62) and 1983–1987 in the South region (RR = 0.25; 95%CI 0.12–0.54). CONCLUSIONS Age had a significant effect on mortality from oral and oropharyngeal cancer in all regions. In the North, Northeast, and Central-West regions, an increase in risk was observed in the most recent cohorts, while in the South and Southeast regions, these cohorts presented a lower risk when compared to the older cohorts.

RESUMO OBJETIVO Estimar o efeito da idade, período e coorte de nascimento na mortalidade por câncer de boca e orofaringe no Brasil e suas macrorregiões. MÉTODO Foram analisados os óbitos por câncer de boca e orofaringe de 1983 a 2017. Aplicou-se o modelo de regressão de Poisson, utilizando funções estimáveis propostas por Holford. RESULTADOS No período de 1983 a 2017, foram registrados no Brasil 142.634 óbitos por câncer de boca e orofaringe, 81% entre o sexo masculino, e as regiões Sul e Sudeste apresentaram as taxas mais altas. Os maiores efeitos de período foram observados na mortalidade masculina das regiões Sudeste e Centro-Oeste para o período de referência 2003–2007. Nas regiões Norte, Nordeste e Centro-Oeste foi observado aumento do risco de mortalidade nas coortes masculinas mais recentes. Na região Norte o maior risco identificado foi para homens nascidos entre 1973 e 1977 (RR = 1,47; IC95% 1,05–2,08); no Nordeste, para homens nascidos entre 1988 e 1992 (RR = 2,77; IC95% 1,66–4,63); e no Centro-Oeste, para mulheres nascidas entre 1973 e 1977 (RR = 2,01; IC95% 1,19–3,39). Nas regiões Sudeste e Sul, as coortes mais recentes apresentaram taxas de mortalidade mais baixas. O menor risco na região Sudeste foi observado na coorte masculina nascida entre 1978 e 1982 (RR = 0,53; IC95% = 0,45–0,62), e entre 1983 e 1987 na região Sul (RR = 0,25; IC95% 0,12–0,54). CONCLUSÕES A idade teve efeito significativo na mortalidade por câncer de boca e orofaringe em todas as regiões. Nas regiões Norte, Nordeste e Centro-Oeste, foi observado aumento do risco nas coortes mais recentes, enquanto nas regiões Sul e Sudeste essas coortes apresentaram risco menor quando comparadas às coortes mais antigas.

ABSTRACT OBJECTIVE Estimate the effect of age, period, and birth cohort on mortality from oral and oropharyngeal cancer in Brazil and its macro-regions. METHODS Deaths from oral and oropharyngeal cancer from 1983 to 2017 were analyzed. The Poisson regression model was applied, using estimable functions proposed by Holford. RESULTS From 1983 to 2017, 142,634 deaths from oral and oropharyngeal cancer were registered in Brazil, 81% among men, and the South and Southeast regions had the highest rates. The most significant period effects were observed in male mortality in the Southeast and Central-West regions for the 2003–2007 reference period. In the North, Northeast, and Central-West regions, an increased risk of mortality was observed in the most recent male cohorts. In the North region, the most significant risk identified was for men born during 1973–1977 (RR = 1.47; 95%CI 1.05–2.08); in the Northeast, for men born during 1988–1992 (RR = 2.77; 95%CI 1.66–4.63); and in the Central-West, for women born during 1973–1977 (RR = 2.01; 95%CI 1.19–3.39). In the Southeast and South regions, the most recent cohorts had lower mortality rates. The lowest risk in the Southeast region was observed in the male cohort born during 1978–1982 (RR = 0.53; 95%CI 0.45–0.62) and 1983–1987 in the South region (RR = 0.25; 95%CI 0.12–0.54). CONCLUSIONS Age had a significant effect on mortality from oral and oropharyngeal cancer in all regions. In the North, Northeast, and Central-West regions, an increase in risk was observed in the most recent cohorts, while in the South and Southeast regions, these cohorts presented a lower risk when compared to the older cohorts.

Resumo: O objetivo foi estimar o efeito do acúmulo de risco decorrente da pobreza na perda dentária aos 31 anos. Foram utilizados dados longitudinais da coorte de nascidos vivos de 1982, na cidade de Pelotas, Rio Grande do Sul, Brasil. Para a construção das variáveis de trajetória de renda, foram utilizados quatro pontos do tempo: nascimento, 15, 24 e 30 anos. Os fatores de confusão avaliados foram sexo, escolaridade materna, cor da pele da mãe e fumo aos 24 anos. Como potenciais mediadores, foram utilizados a trajetória de serviço odontológico e a cárie dentária baseada no Significant Index Caries (SIC). Para criação da variável de trajetória do modelo de acúmulo de risco, utilizou-se abordagem analítica de group-based trajectory modeling. O desfecho estudado foi o número de dentes perdidos aos 31 anos. A média de dentes perdidos aos 31 anos foi de 1,25 dente. No modelo de acúmulo de risco, após o ajuste para os confusores e mediadores, os indivíduos que estiveram pobres em um ou dois pontos do tempo apresentaram razão de risco - RR = 1,92 (IC95%: 1,40-2,63), e os que apresentaram três ou quatro episódios de pobreza apresentaram RR = 1,97 (IC95%: 1,24-3,13) para a perda dentária. Os resultados evidenciam o efeito do acúmulo de pobreza ao longo da vida na perda dentária. O efeito é ampliado entre os indivíduos que permaneceram mais tempo expostos à pobreza. As políticas públicas que visem a melhorar as condições de renda atuarão também na redução da perda dentária.

Abstract: The objective was to estimate the effect of accumulated risk from poverty and tooth loss at 31 years, using longitudinal data from the 1982 live birth cohort in Pelotas, Rio Grande do Sul State, Brazil. The income trajectory variables were built with four time points: birth and 15, 24, and 30 years of age. Potential confounding factors were sex, maternal schooling, maternal skin color, and smoking at 24 years. Potential mediators used the history of dentistry services use and caries based on the Significant Index Caries (SIC). The trajectory variable in the accumulated risk model was created with group-based trajectory modeling. The target outcome was the number of missing teeth at 31 years. Mean number of missing teeth at 31 years was 1.25. In the accumulated risk model after adjusting for confounders and mediators, individuals that were poor at one or two time points showed risk ratio - RR = 1.92 (95%CI: 1.40-2.63), and those with three or four episodes of poverty showed RR = 1.97 (95%CI: 1.24-3.13) for tooth loss. The results highlight the effect of lifetime poverty on tooth loss. The effect was expanded in individuals that were exposed to poverty longer. Public policies aimed at improving income conditions also help reduce tooth loss.

Resumen: El objetivo fue estimar el efecto de la acumulación de riesgo, derivado de la pobreza, en la pérdida dental a los 31 años. Se utilizaron datos longitudinales de la cohorte de nacidos vivos de 1982, en la ciudad de Pelotas, Rio Grande do Sul, Brasil. Para la construcción de las variables de trayectoria de renta se utilizaron cuatro puntos del tiempo: nacimiento, 15, 24 y 30 años. Los factores de confusión evaluados fueron: sexo, escolaridad materna, color de la piel de la madre y consumo de tabaco a los 24 años. Como potenciales mediadores se utilizó la trayectoria de servicios odontológicos y caries dental, basada en el Significant Index Caries (SIC). Para la creación de la variable de trayectoria del modelo de acumulación de riesgo se utilizó el abordaje analítico de group-based trajectory modeling. El resultado estudiado fue el número de dientes perdidos a los 31 años. La media de dientes perdidos a los 31 años fue 1,25 dientes. En el modelo de acumulación de riesgo, tras el ajuste para confusores y mediadores, los individuos que eran pobres en uno o dos puntos del tiempo presentaron razón de riesgo - RR = 1,92 (IC95%: 1,40-2,63) y quienes presentaron tres o cuatro episodios de pobreza presentaron RR = 1,97 (IC95%: 1,24-3,13) respecto a la pérdida dental. Los resultados evidencian el efecto de la acumulación de pobreza a lo largo de la vida en la pérdida dental. El efecto se amplía entre los individuos que permanecieron más tiempo expuestos a la pobreza. Las políticas públicas que tengan por objetivo mejorar las condiciones de renta actuarán también en la reducción de la pérdida dental.

Resumo: O objetivo foi estimar o efeito do acúmulo de risco decorrente da pobreza na perda dentária aos 31 anos. Foram utilizados dados longitudinais da coorte de nascidos vivos de 1982, na cidade de Pelotas, Rio Grande do Sul, Brasil. Para a construção das variáveis de trajetória de renda, foram utilizados quatro pontos do tempo: nascimento, 15, 24 e 30 anos. Os fatores de confusão avaliados foram sexo, escolaridade materna, cor da pele da mãe e fumo aos 24 anos. Como potenciais mediadores, foram utilizados a trajetória de serviço odontológico e a cárie dentária baseada no Significant Index Caries (SIC). Para criação da variável de trajetória do modelo de acúmulo de risco, utilizou-se abordagem analítica de group-based trajectory modeling. O desfecho estudado foi o número de dentes perdidos aos 31 anos. A média de dentes perdidos aos 31 anos foi de 1,25 dente. No modelo de acúmulo de risco, após o ajuste para os confusores e mediadores, os indivíduos que estiveram pobres em um ou dois pontos do tempo apresentaram razão de risco - RR = 1,92 (IC95%: 1,40-2,63), e os que apresentaram três ou quatro episódios de pobreza apresentaram RR = 1,97 (IC95%: 1,24-3,13) para a perda dentária. Os resultados evidenciam o efeito do acúmulo de pobreza ao longo da vida na perda dentária. O efeito é ampliado entre os indivíduos que permaneceram mais tempo expostos à pobreza. As políticas públicas que visem a melhorar as condições de renda atuarão também na redução da perda dentária.

Abstract: The objective was to estimate the effect of accumulated risk from poverty and tooth loss at 31 years, using longitudinal data from the 1982 live birth cohort in Pelotas, Rio Grande do Sul State, Brazil. The income trajectory variables were built with four time points: birth and 15, 24, and 30 years of age. Potential confounding factors were sex, maternal schooling, maternal skin color, and smoking at 24 years. Potential mediators used the history of dentistry services use and caries based on the Significant Index Caries (SIC). The trajectory variable in the accumulated risk model was created with group-based trajectory modeling. The target outcome was the number of missing teeth at 31 years. Mean number of missing teeth at 31 years was 1.25. In the accumulated risk model after adjusting for confounders and mediators, individuals that were poor at one or two time points showed risk ratio - RR = 1.92 (95%CI: 1.40-2.63), and those with three or four episodes of poverty showed RR = 1.97 (95%CI: 1.24-3.13) for tooth loss. The results highlight the effect of lifetime poverty on tooth loss. The effect was expanded in individuals that were exposed to poverty longer. Public policies aimed at improving income conditions also help reduce tooth loss.

Resumen: El objetivo fue estimar el efecto de la acumulación de riesgo, derivado de la pobreza, en la pérdida dental a los 31 años. Se utilizaron datos longitudinales de la cohorte de nacidos vivos de 1982, en la ciudad de Pelotas, Rio Grande do Sul, Brasil. Para la construcción de las variables de trayectoria de renta se utilizaron cuatro puntos del tiempo: nacimiento, 15, 24 y 30 años. Los factores de confusión evaluados fueron: sexo, escolaridad materna, color de la piel de la madre y consumo de tabaco a los 24 años. Como potenciales mediadores se utilizó la trayectoria de servicios odontológicos y caries dental, basada en el Significant Index Caries (SIC). Para la creación de la variable de trayectoria del modelo de acumulación de riesgo se utilizó el abordaje analítico de group-based trajectory modeling. El resultado estudiado fue el número de dientes perdidos a los 31 años. La media de dientes perdidos a los 31 años fue 1,25 dientes. En el modelo de acumulación de riesgo, tras el ajuste para confusores y mediadores, los individuos que eran pobres en uno o dos puntos del tiempo presentaron razón de riesgo - RR = 1,92 (IC95%: 1,40-2,63) y quienes presentaron tres o cuatro episodios de pobreza presentaron RR = 1,97 (IC95%: 1,24-3,13) respecto a la pérdida dental. Los resultados evidencian el efecto de la acumulación de pobreza a lo largo de la vida en la pérdida dental. El efecto se amplía entre los individuos que permanecieron más tiempo expuestos a la pobreza. Las políticas públicas que tengan por objetivo mejorar las condiciones de renta actuarán también en la reducción de la pérdida dental.

RESUMO OBJETIVO Estimar os anos de vida perdidos pela população brasileira devido ao câncer de boca e faringe de 1979 a 2013 e analisar a tendências temporais no período estudado, segundo região do país, sexo e sítio anatômico. MÉTODOS Os registros de óbitos foram obtidos do Sistema de Informações sobre Mortalidade e os dados referentes à população, dos censos do Instituto Brasileiro de Geografia e Estatística de 1980, 1991, 2000, 2010 e de estimativas intercensitárias para os demais anos. Foram calculadas as taxas de anos de vida potencialmente perdidos aplicando o método sugerido por Romeder e McWhinnie, e suas tendências foram calculadas usando o método de Prais-Winsten com correção para autocorrelação de primeira ordem. As séries históricas foram alisadas com técnica de média móvel central de ordem 3 para redução de ruído branco. RESULTADOS No período de 1979 a 2013 no Brasil, houve um total de 107.506 mortes prematuras devido ao câncer de boca e faringe, o que gerou um total de 1.589.501 anos potenciais de vida perdidos, equivalendo a uma taxa de 3,6 por 10.000 habitantes. O sexo masculino, com uma taxa seis vezes maior que a do sexo feminino, contribuiu com 85% dos anos perdidos. As tendências das taxas de anos de vida perdidos mostraram aumento anual de 0,72% nos homens, 1,13% nas mulheres e 1,05% para o câncer de faringe. CONCLUSÕES A taxa de anos potenciais de vida perdidos por câncer de boca e faringe no país mostrou tendência de aumento dentro do período estudado em ambos os sexos, assim como para o câncer de faringe e para as regiões Norte, Nordeste e Centro-Oeste.

ABSTRACT OBJECTIVE To estimate the years of life lost by the Brazilian population due to mouth and pharynx cancer from 1979 to 2013, and analyze the temporal trends in the studied period, according to the country’s region, sex and anatomical site. METHODS The death records were obtained from the Mortality Information System and the data referring to the population, from the censuses of the Brazilian Institute of Geography and Statistics of 1980, 1991, 2000, 2010, and from intercensal estimates for the other years. The rates of potential years of life lost were calculated by applying the method suggested by Romeder and McWhinnie, and their trends were calculated using the Prais-Winsten method with first-order autocorrelation. The historical series were smoothed with the centered moving average technique of third order for white noise reduction. RESULTS In the period from 1979 to 2013 in Brazil, there were a total of 107,506 premature deaths due to mouth and pharynx cancer, which generated a total of 1,589,501 potential years of life lost, the equivalent to a rate of 3.6 per 10,000 inhabitants. Males, whose rate was six times higher than for females, contributed with 85% of the years lost. The trends in the rates of years of life lost showed an annual 0.72% increase for men, 1.13% for women and 1.05% for pharynx cancer. CONCLUSIONS The rate of potential years of life lost due to mouth and pharynx cancer in the country showed an upward trend within the studied period for both sexes, as well as for pharynx cancer and for the North, Northeast and Midwest regions.

RESUMO OBJETIVO Estimar os anos de vida perdidos pela população brasileira devido ao câncer de boca e faringe de 1979 a 2013 e analisar a tendências temporais no período estudado, segundo região do país, sexo e sítio anatômico. MÉTODOS Os registros de óbitos foram obtidos do Sistema de Informações sobre Mortalidade e os dados referentes à população, dos censos do Instituto Brasileiro de Geografia e Estatística de 1980, 1991, 2000, 2010 e de estimativas intercensitárias para os demais anos. Foram calculadas as taxas de anos de vida potencialmente perdidos aplicando o método sugerido por Romeder e McWhinnie, e suas tendências foram calculadas usando o método de Prais-Winsten com correção para autocorrelação de primeira ordem. As séries históricas foram alisadas com técnica de média móvel central de ordem 3 para redução de ruído branco. RESULTADOS No período de 1979 a 2013 no Brasil, houve um total de 107.506 mortes prematuras devido ao câncer de boca e faringe, o que gerou um total de 1.589.501 anos potenciais de vida perdidos, equivalendo a uma taxa de 3,6 por 10.000 habitantes. O sexo masculino, com uma taxa seis vezes maior que a do sexo feminino, contribuiu com 85% dos anos perdidos. As tendências das taxas de anos de vida perdidos mostraram aumento anual de 0,72% nos homens, 1,13% nas mulheres e 1,05% para o câncer de faringe. CONCLUSÕES A taxa de anos potenciais de vida perdidos por câncer de boca e faringe no país mostrou tendência de aumento dentro do período estudado em ambos os sexos, assim como para o câncer de faringe e para as regiões Norte, Nordeste e Centro-Oeste.

ABSTRACT OBJECTIVE To estimate the years of life lost by the Brazilian population due to mouth and pharynx cancer from 1979 to 2013, and analyze the temporal trends in the studied period, according to the country’s region, sex and anatomical site. METHODS The death records were obtained from the Mortality Information System and the data referring to the population, from the censuses of the Brazilian Institute of Geography and Statistics of 1980, 1991, 2000, 2010, and from intercensal estimates for the other years. The rates of potential years of life lost were calculated by applying the method suggested by Romeder and McWhinnie, and their trends were calculated using the Prais-Winsten method with first-order autocorrelation. The historical series were smoothed with the centered moving average technique of third order for white noise reduction. RESULTS In the period from 1979 to 2013 in Brazil, there were a total of 107,506 premature deaths due to mouth and pharynx cancer, which generated a total of 1,589,501 potential years of life lost, the equivalent to a rate of 3.6 per 10,000 inhabitants. Males, whose rate was six times higher than for females, contributed with 85% of the years lost. The trends in the rates of years of life lost showed an annual 0.72% increase for men, 1.13% for women and 1.05% for pharynx cancer. CONCLUSIONS The rate of potential years of life lost due to mouth and pharynx cancer in the country showed an upward trend within the studied period for both sexes, as well as for pharynx cancer and for the North, Northeast and Midwest regions.

RESUMO OBJETIVO Analisar a tendência das taxas de mortalidade por câncer de boca e de faringe no período de 2002–2013 no Brasil segundo sexo, sítio anatômico e macrorregião do país. MÉTODOS Os dados sobre mortalidade foram obtidos junto ao Sistema de Informações sobre Mortalidade e os dados das populações foram obtidos junto ao Instituto Brasileiro de Geografia e Estatística. A tendência das taxas padronizadas por sexo e faixa etária foi calculada por regressão de Prais-Winstein, obtendo a sua variação percentual anual e os respectivos intervalos de confiança de 95%, analisados segundo sexo, macrorregião e sítio anatômico. RESULTADOS O coeficiente médio de mortalidade por câncer de boca foi de 1,87/100.000 habitantes e permaneceu estável durante o período estudado. O coeficiente de mortalidade por câncer de faringe foi de 2,04/100.000 habitantes e apresentou variação percentual anual de -2,6%. Aproximadamente oito em cada 10 óbitos ocorreram entre homens. Observou-se aumento nas taxas por câncer de boca na região Nordeste (variação percentual anual de 6,9%) e diminuição na região Sudeste (variação percentual anual -2,9%). Mortalidade por câncer de faringe diminuiu nas regiões Sudeste e Sul com variação percentual anual de -4,8% e -5,1% respectivamente. Mortalidade por câncer de amígdala, outras glândulas salivares maiores, hipofaringe e outras partes não especificas de boca e faringe, apresentaram tendência de declínio enquanto os demais sítios apresentaram estabilidade. CONCLUSÕES A mortalidade por câncer de faringe apresentou diminuição no período 2002–2013. O câncer de boca apresentou aumento só na região Nordeste. Mortalidade por câncer de amígdala, outras glândulas maiores, hipofaringe e outras localizações mal definidas de lábio, cavidade oral e faringe mostraram declínio.

ABSTRACT OBJECTIVE To analyze the trend of oral and pharyngeal cancer mortality rates in the period of 2002 to 2013 in Brazil according to sex, anatomical site, and macroregion of the country. METHODS The mortality data were obtained from the Mortality Information System and the population data were obtained from the Brazilian Institute of Geography and Statistics. The trend of the rates standardized by sex and age was calculated using the Prais-Winsten estimation, and we obtained the annual percentage change and the respective 95% confidence intervals, analyzed according to sex, macroregion, and anatomical site. RESULTS The average coefficient of oral cancer mortality was 1.87 per 100,000 inhabitants and it remained stable during the study period. The coefficient of pharyngeal cancer mortality was 2.04 per 100,000 inhabitants and it presented an annual percentage change of -2.6%. Approximately eight in every 10 deaths occurred among men. There was an increase in the rates of oral cancer in the Northeast region (annual percentage change of 6.9%) and a decrease in the Southeast region (annual percentage change of -2.9%). Pharyngeal cancer mortality decreased in the Southeast and South regions with annual percentage change of -4.8% and -5.1% respectively. Cancer mortality for tonsil, other major salivary glands, hypopharynx, and other and unspecified parts of mouth and pharynx showed a decreasing trend while the other sites presented stability. CONCLUSIONS Pharyngeal cancer mortality decreased in the period of 2002 to 2013. Oral cancer increased only in the Northeast region. Mortality for tonsil cancer, other major salivary glands, hypopharynx, and other and ill-defined sites in the lip, oral cavity, and pharynx decreased.

RESUMO OBJETIVO Analisar a tendência das taxas de mortalidade por câncer de boca e de faringe no período de 2002–2013 no Brasil segundo sexo, sítio anatômico e macrorregião do país. MÉTODOS Os dados sobre mortalidade foram obtidos junto ao Sistema de Informações sobre Mortalidade e os dados das populações foram obtidos junto ao Instituto Brasileiro de Geografia e Estatística. A tendência das taxas padronizadas por sexo e faixa etária foi calculada por regressão de Prais-Winstein, obtendo a sua variação percentual anual e os respectivos intervalos de confiança de 95%, analisados segundo sexo, macrorregião e sítio anatômico. RESULTADOS O coeficiente médio de mortalidade por câncer de boca foi de 1,87/100.000 habitantes e permaneceu estável durante o período estudado. O coeficiente de mortalidade por câncer de faringe foi de 2,04/100.000 habitantes e apresentou variação percentual anual de -2,6%. Aproximadamente oito em cada 10 óbitos ocorreram entre homens. Observou-se aumento nas taxas por câncer de boca na região Nordeste (variação percentual anual de 6,9%) e diminuição na região Sudeste (variação percentual anual -2,9%). Mortalidade por câncer de faringe diminuiu nas regiões Sudeste e Sul com variação percentual anual de -4,8% e -5,1% respectivamente. Mortalidade por câncer de amígdala, outras glândulas salivares maiores, hipofaringe e outras partes não especificas de boca e faringe, apresentaram tendência de declínio enquanto os demais sítios apresentaram estabilidade. CONCLUSÕES A mortalidade por câncer de faringe apresentou diminuição no período 2002–2013. O câncer de boca apresentou aumento só na região Nordeste. Mortalidade por câncer de amígdala, outras glândulas maiores, hipofaringe e outras localizações mal definidas de lábio, cavidade oral e faringe mostraram declínio.

ABSTRACT OBJECTIVE To analyze the trend of oral and pharyngeal cancer mortality rates in the period of 2002 to 2013 in Brazil according to sex, anatomical site, and macroregion of the country. METHODS The mortality data were obtained from the Mortality Information System and the population data were obtained from the Brazilian Institute of Geography and Statistics. The trend of the rates standardized by sex and age was calculated using the Prais-Winsten estimation, and we obtained the annual percentage change and the respective 95% confidence intervals, analyzed according to sex, macroregion, and anatomical site. RESULTS The average coefficient of oral cancer mortality was 1.87 per 100,000 inhabitants and it remained stable during the study period. The coefficient of pharyngeal cancer mortality was 2.04 per 100,000 inhabitants and it presented an annual percentage change of -2.6%. Approximately eight in every 10 deaths occurred among men. There was an increase in the rates of oral cancer in the Northeast region (annual percentage change of 6.9%) and a decrease in the Southeast region (annual percentage change of -2.9%). Pharyngeal cancer mortality decreased in the Southeast and South regions with annual percentage change of -4.8% and -5.1% respectively. Cancer mortality for tonsil, other major salivary glands, hypopharynx, and other and unspecified parts of mouth and pharynx showed a decreasing trend while the other sites presented stability. CONCLUSIONS Pharyngeal cancer mortality decreased in the period of 2002 to 2013. Oral cancer increased only in the Northeast region. Mortality for tonsil cancer, other major salivary glands, hypopharynx, and other and ill-defined sites in the lip, oral cavity, and pharynx decreased.

Abstract The present study aimed at understanding the relationship between periodontitis and socio-contextual and individual determinants of health. Data from “The First Uruguayan Oral Health Survey, 2011”, which included 223 and 455 individuals with 35–44 and 65–74 years old respectively, were used. A stratified, multistage cluster sampling design was adopted (cities with ≥ 20.000 residents). Periodontitis was assessed using the modified Community Periodontal Index (CPI) and clinical attachment loss (CAL) (periodontal pocket and CAL ≥ 4 mm). Independent variables included contextual socioeconomic status (SES) measured by proportion of houses with Unsatisfied Basic Needs (UBN) and individual demographic and behavioral factors. Logistic regression multilevel models were generated. Living in contexts with a higher UBN was associated with higher odds for periodontitis in both age groups, even when adjusting for individual level variables (odds ratio [OR] = 1.51, 95%CI = 1.42–1.60 and 1.31, 95%CI = 1.21–1.42, respectively). Being male or heavy smoker increased the odds of periodontitis in this population for both age groups. Social structure impacts periodontal disease by modifying individual socioeconomic situations: in better socioeconomic context, UBN acts increasing the protector role of socioeconomic situation but in a poverty context the role is attenuated. Conclusions for this study are that periodontitis varies across contextual socio-demographic groups being higher in the population with a lower SES, challenging health authorities to integrate oral health into national non-communicable diseases programs.