Resumo Este estudo objetivou analisar as possíveis associações entre o Escore da Estrutura de Controle de Infecção (EECI), os serviços de saúde e características sociais dos municípios brasileiros. Foram analisados dados secundários do terceiro ciclo 2017-2018 do Programa Nacional de Melhoria do Acesso e Qualidade da Atenção Básica (PMAQ). Seis variáveis independentes - Índice FIRJAN de Desenvolvimento Municipal, número de habitantes, número de Equipes de Saúde da Família que recebiam incentivo financeiro do governo federal, gasto com saúde per capita e número de Equipes de Saúde Bucal modalidades 1 e 2 - foram incluídas para avaliar a influência sobre o EECI, medido para cada município brasileiro. Para a análise dos dados, foi utilizado o modelo de Árvore de Classificação e Regressão no IBM SPSS 25. Foram incluídos 4.900 municípios, e o EECI médio foi de 0,905 (±0,092). Observou-se uma associação positiva entre o gasto com saúde per capita, o desenvolvimento municipal e o desfecho. Por outro lado, municípios com maior número de Equipes de Saúde da Família com incentivo financeiro do governo federal apresentaram menor média do EECI. Os achados sugerem que existem desigualdades nas estruturas de controle de infecções no país, relacionadas aos serviços de saúde e às características sociais dos municípios.

Abstract This study aimed to analyze possible associations between the Infection Control Structure Score (ICSS), health services, and social characteristics of the municipalities in Brazil. Secondary data from the third cycle 2017-2018 of the Brazilian National Program for Improving Primary Care Access and Quality (PMAQ) was analyzed. Six independent variables - FIRJAN Index of Municipal Development, number of inhabitants, number of family health teams receiving a financial incentive from the federal government, healthcare expenditure per capita, and number of Oral Health Teams modalities 1 and 2 - were included to assess their influence on ICSS, measured for each Brazilian town. Data analysis used the Classification and Regression Tree model performed with IBM SPSS 25. A total of 4,900 municipalities were included, and the mean ICSS was 0.905 (±0.092). A positive relationship was observed between healthcare expenditure per capita, municipal development, and the outcome. Conversely, towns with a higher number of family health teams receiving a financial incentive from the federal government showed lower mean ICSS. The findings suggest that inequalities in the infection control structures exist within the country, and they were related to the health services and social characteristics of the municipalities.

Abstract This study aimed to analyze possible associations between the Infection Control Structure Score (ICSS), health services, and social characteristics of the municipalities in Brazil. Secondary data from the third cycle 2017-2018 of the Brazilian National Program for Improving Primary Care Access and Quality (PMAQ) was analyzed. Six independent variables - FIRJAN Index of Municipal Development, number of inhabitants, number of family health teams receiving a financial incentive from the federal government, healthcare expenditure per capita, and number of Oral Health Teams modalities 1 and 2 - were included to assess their influence on ICSS, measured for each Brazilian town. Data analysis used the Classification and Regression Tree model performed with IBM SPSS 25. A total of 4,900 municipalities were included, and the mean ICSS was 0.905 (±0.092). A positive relationship was observed between healthcare expenditure per capita, municipal development, and the outcome. Conversely, towns with a higher number of family health teams receiving a financial incentive from the federal government showed lower mean ICSS. The findings suggest that inequalities in the infection control structures exist within the country, and they were related to the health services and social characteristics of the municipalities.

Resumo Este estudo objetivou analisar as possíveis associações entre o Escore da Estrutura de Controle de Infecção (EECI), os serviços de saúde e características sociais dos municípios brasileiros. Foram analisados dados secundários do terceiro ciclo 2017-2018 do Programa Nacional de Melhoria do Acesso e Qualidade da Atenção Básica (PMAQ). Seis variáveis independentes - Índice FIRJAN de Desenvolvimento Municipal, número de habitantes, número de Equipes de Saúde da Família que recebiam incentivo financeiro do governo federal, gasto com saúde per capita e número de Equipes de Saúde Bucal modalidades 1 e 2 - foram incluídas para avaliar a influência sobre o EECI, medido para cada município brasileiro. Para a análise dos dados, foi utilizado o modelo de Árvore de Classificação e Regressão no IBM SPSS 25. Foram incluídos 4.900 municípios, e o EECI médio foi de 0,905 (±0,092). Observou-se uma associação positiva entre o gasto com saúde per capita, o desenvolvimento municipal e o desfecho. Por outro lado, municípios com maior número de Equipes de Saúde da Família com incentivo financeiro do governo federal apresentaram menor média do EECI. Os achados sugerem que existem desigualdades nas estruturas de controle de infecções no país, relacionadas aos serviços de saúde e às características sociais dos municípios.

ABSTRACT. This study aimed to evaluate the nutrient intake, milk production, and production costs of dairy goats fed diets containing the rations with cactus cladodes (Opuntia stricta or Nopalea cochenillifera) associated with silage (Sorghum bicolor) or Tifton hay (Cynodon spp). Twelve pluriparous Saanen and Anglo Nubiana goats (42.25 ± 5.48 kg) at eight weeks of lactation were used. Treatments lasted 60 days, consisting of four periods of 15 days, distributed in three Latin square (4×4) with four diets. The treatments represented by diets with different associated feed: SSOP (Sorghum Silage + Opuntia); THOP (Tifton hay + Opuntia); SSNO (Sorghum Silage + Nopalea); and THNO (Tifton hay + Nopalea), in addition to concentrate in all diets. There were differences (p < 0.05) for the intakes of DM, OM, with higher values observed for goats fed the diets THNO, THOP, and SSNO, and for CP, NDF and ADF were higher for THNO and SSNO diets. Similar behavior occurred for voluntary and total water intake. The milk production and feed efficiency did not differ (p > 0.05). Costs with food, milk revenue, and gross revenue were not influenced by diets (p > 0.05). The Opuntia or Nopalea cactus cladodes genotypes associated with sorghum silage or tifton hay can be used to feed dairy goats in the semiarid region. ABSTRACT intake cochenillifera Sorghum bicolor Cynodon spp. spp . spp) 42.25 4225 42 25 (42.2 548 5 48 5.4 kg 6 days 1 4×4 44 4 (4×4 Opuntia) Nopalea) Nopalea, , p 0.05 005 0 05 DM OM CP 0.05. food region 42.2 422 2 (42. 54 5. 4× (4× 0.0 00 42. (42 (4 0. (

Abstract Background: Tele-cardiology tools are valuable strategies to improve risk stratification. Objective: We aimed to evaluate the accuracy of tele-electrocardiography (ECG) to predict abnormalities in screening echocardiography (echo) in primary care (PC). Methods: In 17 months, 6 health providers at 16 PC units were trained on simplified handheld echo protocols. Tele-ECGs were recorded for final diagnosis by a cardiologist. Consented patients with major ECG abnormalities by the Minnesota code, and a 1:5 sample of normal individuals underwent clinical questionnaire and screening echo interpreted remotely. Major heart disease was defined as moderate/severe valve disease, ventricular dysfunction/hypertrophy, pericardial effusion, or wall-motion abnormalities. Association between major ECG and echo abnormalities was assessed by logistic regression as follows: 1) unadjusted model; 2) model 1 adjusted for age/sex; 3) model 2 plus risk factors (hypertension/diabetes); 4) model 3 plus history of cardiovascular disease (Chagas/rheumatic heart disease/ischemic heart disease/stroke/heart failure). P-values < 0.05 were considered significant. Results: A total 1,411 patients underwent echo; 1,149 (81%) had major ECG abnormalities. Median age was 67 (IQR 60 to 74) years, and 51.4% were male. Major ECG abnormalities were associated with a 2.4-fold chance of major heart disease on echo in bivariate analysis (OR = 2.42 [95% CI 1.76 to 3.39]), and remained significant after adjustments in models (p < 0.001) 2 (OR = 2.57 [95% CI 1.84 to 3.65]), model 3 (OR = 2.52 [95% CI 1.80 to3.58]), and model 4 (OR = 2.23 [95%CI 1.59 to 3.19]). Age, male sex, heart failure, and ischemic heart disease were also independent predictors of major heart disease on echo. Conclusions: Tele-ECG abnormalities increased the likelihood of major heart disease on screening echo, even after adjustments for demographic and clinical variables. Background Telecardiology Tele cardiology stratification Objective teleelectrocardiography tele electrocardiography (ECG (echo PC. . (PC) Methods months protocols TeleECGs ECGs cardiologist code 15 5 1: remotely moderatesevere moderate severe dysfunctionhypertrophy dysfunction hypertrophy dysfunction/hypertrophy effusion wallmotion wall motion follows age/sex agesex sex hypertension/diabetes hypertensiondiabetes hypertension diabetes (hypertension/diabetes) Chagas/rheumatic Chagasrheumatic Chagas rheumatic diseaseischemic diseasestrokeheart stroke failure. failure failure) Pvalues P values 005 0 05 0.0 Results 1411 411 1,41 1149 149 1,14 81% 81 (81% IQR 74 years 514 51 51.4 2.4fold 24fold fold 2.4 OR 242 42 95% 95 [95 176 76 1.7 3.39, 339 3.39 , 39 3.39]) p 0.001 0001 001 257 57 2.5 184 84 1.8 3.65, 365 3.65 65 3.65]) 252 52 180 80 to3.58, to358 to3.58 to3 58 to3.58]) 223 23 2.2 95%CI 95CI 159 59 1.5 3.19. 319 3.19 19 3.19]) Age Conclusions TeleECG variables (PC (hypertension/diabetes 00 0. 141 41 1,4 114 14 1,1 8 (81 7 51. 4fold 24 2. 9 [9 1. 33 3.3 3.39] 0.00 000 25 18 36 3.6 3.65] to35 to3.5 to3.58] 22 31 3.1 3.19] 1, 11 (8 [ 3. to3. (

Resumo Fundamento: As ferramentas de telecardiologia são estratégias valiosas para melhorar a estratificação de risco. Objetivo: Objetivamos avaliar a acurácia da tele-eletrocardiografia (ECG) para predizer anormalidades no ecocardiograma de rastreamento na atenção primária. Métodos: Em 17 meses, 6 profissionais de saúde em 16 unidades de atenção primária foram treinados em protocolos simplificados de ecocardiografia portátil. Tele-ECGs foram registrados para diagnóstico final por um cardiologista. Pacientes consentidos com anormalidades maiores no ECG pelo código de Minnesota e uma amostra 1:5 de indivíduos normais foram submetidos a um questionário clínico e ecocardiograma de rastreamento interpretado remotamente. A doença cardíaca grave foi definida como doença valvular moderada/grave, disfunção/hipertrofia ventricular, derrame pericárdico ou anormalidade da motilidade. A associação entre alterações maiores do ECG e anormalidades ecocardiográficas foi avaliada por regressão logística da seguinte forma: 1) modelo não ajustado; 2) modelo 1 ajustado por idade/sexo; 3) modelo 2 mais fatores de risco (hipertensão/diabetes); 4) modelo 3 mais história de doença cardiovascular (Chagas/cardiopatia reumática/cardiopatia isquêmica/AVC/insuficiência cardíaca). Foram considerados significativos valores de p < 0,05. Resultados: No total, 1.411 pacientes realizaram ecocardiograma, sendo 1.149 (81%) com anormalidades maiores no ECG. A idade mediana foi de 67 anos (intervalo interquartil de 60 a 74) e 51,4% eram do sexo masculino. As anormalidades maiores no ECG se associaram a uma chance 2,4 vezes maior de doença cardíaca grave no ecocardiograma de rastreamento na análise bivariada (OR = 2,42 [IC 95% 1,76 a 3,39]) e permaneceram significativas (p < 0,001) após ajustes no modelo 2 (OR = 2,57 [IC 95% 1,84 a 3,65]), modelo 3 (OR = 2,52 [IC 95% 1,80 a 3,58]) e modelo 4 (OR = 2,23 [IC 95% 1,59 a 3,19]). Idade, sexo masculino, insuficiência cardíaca e doença cardíaca isquêmica também foram preditores independentes de doença cardíaca grave no ecocardiograma. Conclusões: As anormalidades do tele-ECG aumentaram a probabilidade de doença cardíaca grave no ecocardiograma de rastreamento, mesmo após ajustes para variáveis demográficas e clínicas. Fundamento Objetivo teleeletrocardiografia tele eletrocardiografia (ECG Métodos meses portátil TeleECGs Tele ECGs cardiologista 15 5 1: remotamente moderadagrave moderada moderada/grave disfunçãohipertrofia disfunção hipertrofia ventricular motilidade forma idade/sexo idadesexo hipertensão/diabetes hipertensãodiabetes hipertensão diabetes (hipertensão/diabetes) Chagas/cardiopatia Chagascardiopatia Chagas cardiopatia reumáticacardiopatia reumática isquêmicaAVCinsuficiência AVC cardíaca. . cardíaca) 005 0 05 0,05 Resultados total 1411 411 1.41 1149 149 1.14 81% 81 (81% intervalo 74 514 51 51,4 masculino 24 2, OR 242 42 IC 95 176 76 1,7 3,39 339 39 3,39] 0,001 0001 001 257 57 2,5 184 84 1,8 3,65, 365 3,65 , 65 3,65]) 252 52 180 80 3,58 358 58 3,58] 223 23 2,2 159 59 1,5 3,19. 319 3,19 19 3,19]) Idade Conclusões teleECG clínicas (hipertensão/diabetes 00 0,0 141 41 1.4 114 14 1.1 8 (81 7 51, 9 1, 3,3 33 0,00 000 25 18 36 3,6 3,65] 3,5 35 22 31 3,1 3,19] 0, 1. 11 (8 3, (

RESUMEN. El avance de la legislación nacional e internacional ha contribuido a reafirmar la dignidad y los derechos fundamentales de las personas con discapacidad. Todavia, la participación sociocultural efectiva de esta población se ve obstaculizada por las barreras discriminatorias impuestas en los más diversos ámbitos de la sociedad. Por tanto, es necesario promover reflexiones sobre la ‘cultura de la normalidad’ dominante, y su consecuente influencia en situaciones de exclusión, opresión y discriminación de sujetos con discapacidad. Esta investigación tuvo como objetivo analizar el concepto de discapacidad en la época contemporánea desde la perspectiva filosófica de Emmanuel Levinas, autor responsable de criticar el pensamiento filosófico occidental, especialmente las acciones de exclusión y discriminación de la alteridad que de él resultan. Para ello se utilizó el método del estado del arte, recogiendo 12 artículos, 11 disertaciones y 4 tesis. Las obras fueron categorizadas de manera cuantitativo-descriptiva y posteriormente analizadas a partir de la obra Totalidade e infinito y estudios contemporáneos sobre discapacidad, ética y responsabilidad. Se observó un análisis crítico de las obras en relación a las acciones e intervenciones actuales dirigidas al público con discapacidad, denunciando su insuficiencia en la garantía de los derechos fundamentales. También se señaló la necesidad de reemplazar las concepciones totalizadoras y universalizadoras de las diferencias por perspectivas de reconocimiento del Otro y consideración de la singularidad humana. Se concluye que la Ética de la Alteridad, propuesta por Levinas, invita a la implicación del Mismo hacia el Otro, para ayudar sin esperar a la reciprocidad, volviéndose, por tanto, relevante en los campos político y académico como un enfoque ético, teórico-práctico y marco analítico para la interpretación de las cuestiones relacionadas con la discapacidad. RESUMEN Todavia sociedad tanto cultura normalidad dominante Levinas occidental resultan arte 1 artículos tesis cuantitativodescriptiva cuantitativo descriptiva responsabilidad humana Alteridad reciprocidad volviéndose ético teóricopráctico teórico práctico

ABSTRACT. The advancement of national and international laws has contributed to reassuring the dignity and fundamental rights of people with disabilities. Even so, the effective sociocultural participation of these people is jeopardized by discriminatory barriers imposed across multiple spheres of society. Therefore, it is necessary to promote reflections about ‘normality culture’ and its consequences in situations of exclusion, oppression, and discrimination of people with disabilities. This study aimed to analyze the contemporary concept of disability in the light of Emmanuel Levinas’s philosophy, author responsible for criticizing Western philosophy affirming that the exclusion of alterity stems from it. To this end, a State of the Art analysis was done, and 12 papers, 11 master’s theses, and 4 doctoral dissertations were found. The works were classified by quantitative characteristics and were later analyzed in the light of Levinas’s major work, Totalidade e infinito, and the contemporary studies on disability, ethics, and responsibility. It was observed that the works had done critical analyses about governmental actions and interventions destined to people with disabilities, showing the insufficiency in ensuring fundamental rights of these people. We also identified the need to substitute conceptions that totalize and universalize the differences with perspectives that recognise the Other in its singularity. This article concludes that the Ethics of Alterity proposed by Levinas invites one to infinite commitment of the Self to the Other, who does not expect anything in return to the aid provided. Therefore, it is relevant to politics and the academic field as an ethical, theoretical, practical, and analytical principle to interpret questions relating to the field of disability studies. ABSTRACT disabilities so society Therefore normality culture oppression Levinass s end 1 papers masters master theses found work infinito ethics responsibility singularity provided ethical theoretical practical

RESUMO. O avanço de legislações nacionais e internacionais contribuiu para a reafirmação da dignidade e dos direitos fundamentais das pessoas com deficiência. Ainda assim, a efetiva participação sociocultural dessa população é prejudicada pelas barreiras discriminatórias impostas nos mais diversos âmbitos da sociedade. Faz-se necessário, portanto, promover reflexões sobre a ‘cultura da normalidade’, e sua consequente influência em situações de exclusão, opressão e discriminação dos sujeitos com deficiência. A presente pesquisa teve como objetivo analisar o conceito de deficiência na contemporaneidade sob a ótica da filosofia de Emmanuel Levinas, autor responsável por tecer críticas ao pensamento filosófico ocidental, principalmente às ações de exclusão e discriminação da alteridade dele decorrentes. Para tanto, utilizou-se o método do Estado da Arte, coletando-se 12 artigos, 11 dissertações e quatro teses. Os trabalhos foram categorizados de maneira quantitativo-descritiva e, posteriormente, analisados a partir da obra Totalidade e infinito e dos estudos contemporâneos sobre deficiência, ética e responsabilidade. Observou-se uma análise crítica dos trabalhos em relação às atuais ações e intervenções voltadas ao público com deficiência, denunciando sua insuficiência na garantia de direitos fundamentais. Constatou-se também a necessidade de substituição de concepções totalizantes e universalizantes das diferenças por perspectivas de reconhecimento do Outro e consideração da singularidade humana. Conclui-se que a Ética da Alteridade, proposta por Levinas, convida ao compromisso infinito do Mesmo para com o Outro, à ajuda sem espera de reciprocidade, fazendo-se, portanto, relevante nos campos político e acadêmico como princípio ético, teórico-prático e analítico para a interpretação de questões relativas à deficiência. RESUMO assim sociedade Fazse Faz se necessário portanto cultura normalidade, normalidade , normalidade’ Levinas ocidental decorrentes tanto utilizouse utilizou Arte coletandose coletando 1 artigos teses quantitativodescritiva quantitativo descritiva posteriormente responsabilidade Observouse Observou Constatouse Constatou humana Concluise Conclui Alteridade reciprocidade fazendose, fazendose fazendo se, fazendo-se ético teóricoprático teórico prático

A new ruthenium polypyridine complex, cis-[Ru(bpy)2(1-meimN)(4-pyCHO)](PF6)2 (WP1), where 1-meimN and pyCHO are the ligands 1-methylimidazole and 4-pyridinecarboxaldehyde, respectively, was prepared as a prototype for use in phototherapeutic process. This compound was characterized by electronic absorption in UV-Visible, FTIR, 1H and 13C NMR, cyclic voltammetry, besides DFT that supported its molecular structure. The compound WP1 was photoreactive, where blue or green light promoted the release of 4-pyCHO ligand. Additionally, this compound was able to interact with DNA, mainly through electrostatic interactions showing photoinduced nuclease activity. There is also photoproduction of superoxide ions using blue or green light suggesting a route for DNA damage. These promising results opened new opportunities for the potential use of this system and analogues as phototherapeutic agents, which is an ongoing study in our lab. complex cisRubpy21meimN4pyCHOPF62 cisRubpymeimNpyCHOPF cis Ru bpy 2 1 meimN 4 PF6 PF cis-[Ru(bpy)2(1-meimN)(4-pyCHO)](PF6) WP1, WP , (WP1) 1meimN 1methylimidazole methylimidazole 4pyridinecarboxaldehyde, 4pyridinecarboxaldehyde pyridinecarboxaldehyde pyridinecarboxaldehyde, 4-pyridinecarboxaldehyde respectively process UVVisible, UVVisible UV Visible, Visible UV-Visible FTIR H C NMR voltammetry structure photoreactive 4pyCHO ligand Additionally activity damage agents lab cisRubpy pyCHOPF cisRubpy21meimN4pyCHOPF6 cis-[Ru(bpy)2(1-meimN)(4-pyCHO)](PF6 (WP1 cisRubpy21meimN4pyCHOPF cis-[Ru(bpy)2(1-meimN)(4-pyCHO)](PF (WP

ABSTRACT Objective: To assess the accuracy of general practitioners in recognizing diabetic retinopathy through color retinal retinography, with a two-hour training course, by comparing the capacity of screening and classifying diabetic retinopathy. Methods: In the first arm of the study, of 142 diabetic patients included, 274 eyes were evaluated, and these patients were examined with an indirect binocular ophthalmoscope and classified according to the degree of diabetic retinopathy. In the second arm of the study, 14 physicians who are not specialists in ophthalmology received two-hour training to diagnose diabetic retinopathy with color retinography, and the accuracy of these professionals in screening for diabetic retinopathy before and after the training course was measured using the photographic images obtained on the first front of the study. Results: There was a significant increase in sensitivity (82% to 99%) and specificity (44% to 83%) in detecting diabetic retinopathy by general practitioners, after attending the training. Conclusion: Qualified general practitioners can assess diabetic retinopathy through color retinography, and the screening program for this diabetes complication is a viable and beneficial proposal for the country. Objective retinography twohour two hour Methods study included 27 evaluated 1 Results 82% 82 (82 99% 99 44% 44 (44 83% 83 Conclusion country 2 8 (8 9 4 (4 (

RESUMO Objetivo: Avaliar a acurácia de médicos generalistas em reconhecer a retinopatia diabética por meio da retinografia colorida, com um curso de capacitação com duração de 2 horas, comparando a capacidade de rastrear e classificar a retinopatia diabética em relação ao exame presencial com oftalmologista. Métodos: No primeiro braço do estudo, de 142 pacientes diabéticos incluídos, avaliaram-se 274 olhos, em que esses pacientes foram examinados com oftalmoscópio binocular indireto e classificados quanto ao grau da retinopatia diabética. No segundo braço do estudo, 14 médicos não especialistas em oftalmologia receberam um treinamento de 2 horas para o diagnóstico de retinopatia diabética com a retinografia colorida e se aferiu a acurácia desses profissionais em rastrear a retinopatia diabética antes e depois do curso de capacitação, utilizando as retinografias obtidas na primeira frente do estudo. Resultados: Verificou-se aumento significativo da sensibilidade (82% para 99%) e da especificidade (44% para 83%) na detecção da retinopatia diabética pelos médicos generalistas, com o curso de capacitação. Conclusão: O médico generalista capacitado pode avaliar a retinopatia diabética por meio da retinografia colorida, sendo o programa de rastreamento dessa complicação do diabetes uma proposta viável e benéfica ao país. Objetivo oftalmologista Métodos estudo incluídos avaliaramse avaliaram 27 olhos 1 Resultados Verificouse Verificou 82% 82 (82 99% 99 44% 44 (44 83% 83 Conclusão país 8 (8 9 4 (4 (

Abstract This study validated the content of an instrument designed to assess the knowledge, involvement (attitudes) and management (practice) of dentists relative to sickle-cell disease (KAPD-SCD). The instrument consisted of five domains composed of a total of thirteen items: I. Dentist’s self-assessment relative to sickle-cell disease; II. Dentist’s knowledge of the repercussions of sickle-cell disease on the stomatognathic system; III. Dentist’s knowledge of the complications of sickle-cell disease in the stomatognathic system; IV. Dentist’s knowledge concerning the dental management of sickle-cell disease patients; and V. Dentist’s involvement in an approach to sickle-cell disease. Twelve experts assigned scores to each item of the instrument. The criteria were clarity, understanding and appropriateness, leaving open fields for comments. Descriptive and content analyses of the data were made. Each expert analyzed 39 assessment units. The percentages considered for agreement were high (>80%), medium (70%-80%), or low (<70%), and each item was maintained or revised according to the percentage observed. There was high consensus in 74% of the assessment units (the corresponding items were maintained), medium consensus in 24% of them (the corresponding items were revised), and disagreement in 2% of them, namely as regards the “appropriateness” of item 5 (“Are there oral complications in sickle-cell disease?”), which was revised. The final version of the instrument had 16 items for different applications such as in the clinical care program, teaching program, or research program, with different cut-off scores for each application. In conclusion, the level of agreement among experts showed evidence of the content validity of the instrument. attitudes (attitudes practice (practice sicklecell sickle cell KAPDSCD. KAPDSCD KAPD SCD . (KAPD-SCD) I Dentists Dentist s selfassessment self II system III IV patients V clarity appropriateness comments made 3 >80%, 80 >80% , (>80%) 70%80%, 7080 70% 80% 70 (70%-80%) <70%, <70% (<70%) observed 74 maintained, maintained) 24 revised, revised) 2 “appropriateness Are disease, disease?”) 1 program cutoff cut off application conclusion (KAPD-SCD 8 >80 (>80% 70%80% 708 7 (70%-80% <70 (<70% disease?” >8 (>80 70%80 (70%-80 <7 (<70 disease? > (>8 70%8 (70%-8 < (<7 (> (70%- (< ( (70% (70 (7

In this study, nanostructured coatings of VN2/Fe3N/Fe4N are synthesized by Plasma Deposition (CCPD) using a vanadium cathodic cage and subject to cathodic and floating potential treatments. Microstructural and mechanical properties of coated SAE 1080 steel samples are investigated using X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Vickers microhardness (HV), and surface roughness analysis. The coating produced under cathodic potential treatment exhibited a nitride-based microstructure (VN2, Fe3N, Fe4N), with surface morphology consisting of clusters of granular structures with varied particle sizes. The coating produced under floating potential predominantly exhibited the iron nitride phase (Fe3N) with a morphology composed of uniformly sized grains. Microhardness testing showed that both layers exhibited more excellent plastic deformation resistance than the substrate. Roughness measurements confirmed a more organized microstructure profile for the sample treated under floating potential. This study demonstrates that the CCPD-produced cathodic potential coating can be utilized in tribological applications. VN2Fe3NFe4N VNFeNFeN VN2 Fe3N Fe4N VN Fe N CCPD (CCPD treatments 108 Xray X ray XRD, XRD , (XRD) SEM, SEM (SEM) HV, HV (HV) analysis nitridebased based VN2, (VN2 FeN Fe4N, Fe4N) sizes (Fe3N grains substrate CCPDproduced applications NFe 10 (XRD (SEM (HV (VN 1

Abstract Immunoglobulin G4-related disease is a systemic immune-mediated disease with insidious evolution characterized by fibroinflammatory lesions over virtually any organ system. Despite the remarkable progression of knowledge, its etiology remains undefined. Due to its relapse-remitting pattern, it could accumulate irreversible damage, increasing comorbidities and mortality. This paper emphasizes key concepts for diagnosing and treating patients with this condition. G4related Grelated G4 related G immunemediated immune mediated system knowledge undefined relapseremitting relapse remitting pattern damage mortality condition

ABSTRACT Wild birds have great prominence in the transmission of diseases to humans, mainly due to their ease of access to human populations, raising concerns about the potential impact of that proximity on public health. The present study reports ARV and PBV occurrence in wild birds from an environmental protection area in the Amazon biome, in Pará state, Brazil. We obtained 155 fecal specimens from 47 species of wild birds for RNA extraction, ARV and PBV detection utilizing molecular methods, nucleotide sequencing, and phylogenetic analysis. ARV prevalence was 0.6% (1/155), being positive in an individual of Myrmotherula longipennis, and PBV prevalence was 1.29% (2/155), affecting two individuals of Guira guira. The PBV strains were assigned to genogroup I based on phylogenetic analysis, and they shared a strong phylogenetic link with strains isolated from different geographic locations. The ARV strain was more closely related to strains that had previously circulated in the same region. The presence of ARV and PBV in this habitat suggests that infection cycles of these agents occur naturally in the wild ecosystem, potentially triggering transmission events between bird species and humans. This is the first study on ARV detection in wild birds in Brazil and the first report on the occurrence of PBV in wild Guira guira. Additional studies are required to determine the epidemiology, origin, evolution, and emergence of new potentially pathogenic viruses in the Amazon. humans populations health biome state 15 4 extraction methods sequencing analysis 06 0 6 0.6 1/155, 1155 1/155 , 1 (1/155) longipennis 129 29 1.29 2/155, 2155 2/155 2 (2/155) guira locations region ecosystem epidemiology origin evolution 0. 115 1/15 (1/155 12 1.2 215 2/15 (2/155 11 1/1 (1/15 1. 21 2/1 (2/15 1/ (1/1 2/ (2/1 (1/ (2/ (1 (2 (

RESUMO As aves silvestres têm grande destaque na transmissão de doenças ao homem, principalmente pela facilidade de acesso à população humana, levantando preocupações sobre o potencial impacto dessa proximidade no contexto da saúde pública. O presente estudo relata a ocorrência de ARV e PBV em aves silvestres de uma área de proteção ambiental no bioma Amazônico. Obtivemos 155 espécimes fecais de 47 espécies de aves silvestres, que foram submetidos a extração de RNA, detecção de ARV e PBV por técnicas moleculares, sequenciamento nucleotídico e análise filogenética. A prevalência de infecção por ARV foi 0,6% (1/155), sendo positivo em um indivíduo de Myrmotherula longipennis, e a prevalência de PBV foi 1,29% (2/155), afetando dois insdivíduos de Guira guira. A análise filogenética agrupou as cepas de PBV no genogrupo I, mostrando intensa relação filogenética com cepas isoladas de outras regiões geográficas. A cepa de ARV esteve mais relacionada filogeneticamente a cepas previamente circulantes na mesma região. Este é o primeiro estudo sobre detecção de ARV em aves silvestres no Brasil e o primeiro relato sobre a ocorrência de PBV em Guira guira. A circulação de ARV e PBV nesse ambiente demonstra que os ciclos desses agentes estão ocorrendo de forma natural no ecossistema silvestre, o que pode desencadear possíveis eventos de transmissão entre as espécies aviárias e humanos. Estudos adicionais são necessários para determinar a epidemiologia, origem, evolução e surgimento de novos vírus potencialmente patogênicos na Amazônia. homem humana pública Amazônico 15 4 RNA moleculares 06 0 6 0,6 1/155, 1155 1/155 , 1 (1/155) longipennis 129 29 1,29 2/155, 2155 2/155 2 (2/155) guira I geográficas região silvestre humanos epidemiologia origem Amazônia 0, 115 1/15 (1/155 12 1,2 215 2/15 (2/155 11 1/1 (1/15 1, 21 2/1 (2/15 1/ (1/1 2/ (2/1 (1/ (2/ (1 (2 (

Abstract This study aimed to analyze possible associations between the Infection Control Structure Score (ICSS), health services, and social characteristics of the municipalities in Brazil. Secondary data from the third cycle 2017-2018 of the Brazilian National Program for Improving Primary Care Access and Quality (PMAQ) was analyzed. Six independent variables - FIRJAN Index of Municipal Development, number of inhabitants, number of family health teams receiving a financial incentive from the federal government, healthcare expenditure per capita, and number of Oral Health Teams modalities 1 and 2 - were included to assess their influence on ICSS, measured for each Brazilian town. Data analysis used the Classification and Regression Tree model performed with IBM SPSS 25. A total of 4,900 municipalities were included, and the mean ICSS was 0.905 (±0.092). A positive relationship was observed between healthcare expenditure per capita, municipal development, and the outcome. Conversely, towns with a higher number of family health teams receiving a financial incentive from the federal government showed lower mean ICSS. The findings suggest that inequalities in the infection control structures exist within the country, and they were related to the health services and social characteristics of the municipalities. , (ICSS) Brazil 20172018 2017 2018 2017-201 PMAQ (PMAQ analyzed Development inhabitants capita town 25 4900 4 900 4,90 0905 0 905 0.90 ±0.092. 0092 ±0.092 . 092 (±0.092) development outcome Conversely country (ICSS 2017201 201 2017-20 490 90 4,9 090 0.9 009 ±0.09 09 (±0.092 201720 20 2017-2 49 9 4, 0. 00 ±0.0 (±0.09 20172 2017- ±0. (±0.0 ±0 (±0. ± (±0 (± (

Resumo Este estudo objetivou analisar as possíveis associações entre o Escore da Estrutura de Controle de Infecção (EECI), os serviços de saúde e características sociais dos municípios brasileiros. Foram analisados dados secundários do terceiro ciclo 2017-2018 do Programa Nacional de Melhoria do Acesso e Qualidade da Atenção Básica (PMAQ). Seis variáveis independentes - Índice FIRJAN de Desenvolvimento Municipal, número de habitantes, número de Equipes de Saúde da Família que recebiam incentivo financeiro do governo federal, gasto com saúde per capita e número de Equipes de Saúde Bucal modalidades 1 e 2 - foram incluídas para avaliar a influência sobre o EECI, medido para cada município brasileiro. Para a análise dos dados, foi utilizado o modelo de Árvore de Classificação e Regressão no IBM SPSS 25. Foram incluídos 4.900 municípios, e o EECI médio foi de 0,905 (±0,092). Observou-se uma associação positiva entre o gasto com saúde per capita, o desenvolvimento municipal e o desfecho. Por outro lado, municípios com maior número de Equipes de Saúde da Família com incentivo financeiro do governo federal apresentaram menor média do EECI. Os achados sugerem que existem desigualdades nas estruturas de controle de infecções no país, relacionadas aos serviços de saúde e às características sociais dos municípios. , (EECI) brasileiros 20172018 2017 2018 2017-201 PMAQ. PMAQ . (PMAQ) Municipal habitantes brasileiro 25 4900 4 900 4.90 0905 0 905 0,90 ±0,092. 0092 ±0,092 092 (±0,092) Observouse Observou se desfecho lado país (EECI 2017201 201 2017-20 (PMAQ 490 90 4.9 090 0,9 009 ±0,09 09 (±0,092 201720 20 2017-2 49 9 4. 0, 00 ±0,0 (±0,09 20172 2017- ±0, (±0,0 ±0 (±0, ± (±0 (± (

The volatile composition of coffee exerts a substantial influence on its quality, as it defines the characteristics of the beverage. However, these compounds are influenced by factors within the coffee production chain, such as botanical origin, geography, processing methods, and roasting. Consequently, the identification of such compounds becomes a vital tool for characterizing coffees to these factors. In this context, gas chromatography with headspace extraction is widely used for aroma analysis, providing a composition closer to consumer perception. Headspace extraction offers speed, simplicity, minimal sample preparation, and no need for solvents. In this study, static headspace extraction (SHS) coupled with gas chromatography-mass spectrometry (SHS-GC-MS) was employed to establish the chemical profile of volatile compounds in Coffea arabica and Coffea canephora var. conilon and determine discriminants between the species. A total of 97 compounds, belonging to 17 chemical classes, were identified. The chemometric analysis highlighted furans, phenols, and carboxylic acids as key differentiating classes. Notably, furfuryl alcohol, acetic acid, 4-vinylguaiacol, N-acetyl-4(H)-pyridine, and N-furfurylpyrrole emerged as crucial volatile compounds. The variable selection using Fisher weight applied directly in the chromatograms, produced models consistent with relative area data, with furfuryl alcohol and 4-vinylguaiacol regions being particularly influential in differentiation. quality beverage However chain origin geography methods roasting Consequently context perception speed simplicity preparation solvents study SHS (SHS chromatographymass mass SHSGCMS GC MS (SHS-GC-MS var species 9 1 classes identified furans phenols Notably acid 4vinylguaiacol, 4vinylguaiacol vinylguaiacol 4 vinylguaiacol, Nacetyl4Hpyridine, Nacetyl4Hpyridine NacetylHpyridine N acetyl H pyridine, pyridine N-acetyl-4(H)-pyridine Nfurfurylpyrrole furfurylpyrrole chromatograms data differentiation Nacetyl Hpyridine

ABSTRACT Most Brazilian municipalities do not have regulated areas for solid waste disposal in civil construction. Usually, residues are disposed of vacant lots and dumps, posing risks to the population health and the environment. Soils are the primary means for the disposal or recycling of waste, highlighting the importance of well-characterized soils and their respective landscape. This study aimed to establish a land suitability system for solid residues in civil construction and apply such information in a case study in Southeastern Brazil. An unprecedented digital soil map with a resolution of 30 m was created using the random forest classifier algorithm and soil field prospection information. A guide listing favorable soil-landscape attributes that most prevent soil erosion, water bodies or water table contamination was elaborated and discussed. Thus, such information was linked through a suitability system to classify areas with potential for receiving waste on a daily volume basis as follows: large size: >500 m³ day-1, medium size: >100 m³ day-1 and <300 m³ day-1, and small size <100 m³ day-1. Topography and soil depth were the most limiting factors of the areas in the case study. The proposed attributes as criteria for the suitability system complement the current state legislation. A total of 236 ha closer to the urban perimeter connected by roads in good condition were classified as suitable for managing medium- and small-scale daily volume, whose destination might reduce transportation and installation costs in the study area. Usually dumps environment wellcharacterized well characterized landscape Brazil 3 soillandscape erosion discussed Thus follows 500 >50 day1, day1 day 1, 1 100 >10 day- 300 <30 <10 day1. 1. legislation 23 smallscale scale area 50 >5 10 >1 <3 <1 2 5 > <