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Evaluation of Total Concentration and Bioaccessible Fraction of Metals in Berry Fruits from Different Cultivars
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Pereira, Camila C.
; Souza, Alexander O. de
; Bonemann, Daisa H.
; Oreste, Eliézer Q.
; Antunes, Luis Eduardo C.
; Cadore, Solange
; Ribeiro, Anderson S.
; Vieira, Mariana A.
.








Journal of the Brazilian Chemical Society
- Métricas do periódico
The objective of this work was to evaluate the total concentration and bioaccessible fractions of Ba, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Pb, V and Zn in berry fruits and analyze the influence of different cultivars and growing conditions on the obtained results. The variations in bioaccessible concentrations were from 7.7-30, 17-29, 22-50, 1.8-96, 22-33 and 20-51% of the total concentration, for Ba, Cu, Fe, Mn, Pb and Zn, respectively. Copper showed greater bioaccessibility in blackberry and blueberry. For Fe, bioaccessibility was observed in all strawberries and blueberries and in some blackberries. Zinc presented higher bioaccessible fractions in strawberries. For V, only the sample Blackberry 124 showed bioaccessible concentration, (11% of the total concentration). Regarding the different forms of cultivation, the strawberries that received radiation from the red and white lamps presented a higher production of fruit compared to the other systems, however, in relation to the absorption of nutrients, a small variation was observed between the fruits. Ba Ca Cd Cr Cu Fe K Mg Mn results 7.730, 7730 7.7 30, 7 30 7.7-30 1729, 1729 17 29, 29 17-29 2250, 2250 22 50, 50 22-50 1.896, 1896 1.8 96, 1 8 96 1.8-96 2233 33 22-3 2051% 2051 20 51% 51 20-51 respectively blueberry blackberries 12 11% 11 (11 concentration. . concentration) cultivation systems however nutrients 730 7.730 773 77 7. 3 7.7-3 172 2 17-2 225 5 22-5 896 1.896 189 18 1. 9 1.8-9 223 22- 205 20-5 (1 73 7.73 7.7- 17- 89 1.89 1.8- 20- (
2.
Impact of a forage legume or nitrogen fertilizer application on ammonia volatilization and nitrous oxide emissions in Brachiaria pastures
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Monteiro, Rafael Cassador
; Santos, Camila Almeida dos
; Rezende, Claudia de Paula
; Pereira, José Marques
; Macedo, Robert de Oliveira
; Alves, Bruno José Rodrigues
; Homem, Bruno Grossi C.
; Urquiaga, Segundo
; Zaman, Mohammad
; Boddey, Robert Michael
.










ABSTRACT The largest proportion of greenhouse gas (GHG) emissions in the Agriculture sector of the Brazilian national GHG inventory is derived from the large (>200 million head) herd of cattle. The greatest contribution to these emissions comes from the enteric methane from cattle, but the direct and indirect emissions of nitrous oxide (N2O) from cattle excreta and N fertilizer are responsible for approximately 9 % of all national anthropogenic GHG emissions. Ammonia (NH3) can be volatilized from N fertilizer and cattle excreta and deposited in sites remote from the source, constituting an indirect source of N2O. This study aimed to determine whether direct N2O emissions and NH3 volatilization from N-fertilized pastures were greater than those derived from a mixed grass-legume pasture without N fertilizer addition. Emissions of N2O and NH3 from excreta and N fertilizer from a Palisade grass (Urochloa brizantha cv. Marandu) monoculture fertilized with 2 × 60 kg N ha-1 yr-1 urea were compared to those from a mixed Palisade grass-forage peanut (Arachis pintoi) pasture. Dung and urine were collected from these cattle, and NH3 losses and N2O emissions from the excreta and from N fertilizer were monitored using static chamber techniques. Volatilization of NH3 and N2O emissions were found to be greater from urine than from dung. Ammonia losses from excreta and urea fertilizer were low, not exceeding 6.8, 1.1, and 4.7 % of the N applied as urine, dung, and fertilizer, respectively. The N2O emissions showed a tendency to be greater for the urine from the N-fertilized compared to the mixed grass-legume pasture, and the N2O emissions from the urine of the N-fertilized pasture ranged from 0.08 to 0.94 % of applied urine N. The N2O emission from the N fertilizer was at maximum 0.46 % of the applied N. The direct N2O emissions and the loss of NH3 by volatilization (indirect N2O emission) from the excreta of cattle grazing the mixed grass-legume pasture were similar to, or lower than, the grazed grass monoculture fertilized with 120 kg N ha-1 yr-1. As the mixed pasture received no N fertilizer and hence no GHG emission from its manufacture or application, introducing forage peanut to the Urochloa brizantha pastures shows potential to be responsible for lower GHG emissions than the N fertilized grass pasture. (GHG >200 200 (>20 head NO O (N2O NH (NH3 Nfertilized grasslegume legume addition cv Marandu 6 ha1 ha 1 ha- yr1 yr yr- grassforage Arachis pintoi techniques dung low 68 8 6.8 11 1.1 47 4 7 4. respectively 008 0 08 0.0 094 94 0.9 046 46 0.4 12 yr1. 1. application >20 20 (>2 (NH 6. 00 0. 09 04 >2 (> > (
3.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
Slipinski, Adam
Linzmeier, Adelita M.
Calor, Adolfo R.
Garda, Adrian A.
Kury, Adriano B.
Fernandes, Agatha C.S.
Agudo-Padrón, Aisur I.
Akama, Alberto
Silva Neto, Alberto M. da
Burbano, Alejandro L.
Menezes, Aleksandra
Pereira-Colavite, Alessandre
Anichtchenko, Alexander
Lees, Alexander C.
Bezerra, Alexandra M.R.
Domahovski, Alexandre C.
Pimenta, Alexandre D.
Aleixo, Alexandre L.P.
Marceniuk, Alexandre P.
Paula, Alexandre S. de
Somavilla, Alexandre
Specht, Alexandre
Camargo, Alexssandro
Newton, Alfred F.
Silva, Aline A.S. da
Santos, Aline B. dos
Tassi, Aline D.
Aragão, Allan C.
Santos, Allan P.M.
Migotto, Alvaro E.
Mendes, Amanda C.
Cunha, Amanda
Chagas Júnior, Amazonas
Sousa, Ana A.T. de
Pavan, Ana C.
Almeida, Ana C.S.
Peronti, Ana L.B.G.
Henriques-Oliveira, Ana L.
Prudente, Ana L.
Tourinho, Ana L.
Pes, Ana M.O.
Carmignotto, Ana P.
Wengrat, Ana P.G. da Silva
Dornellas, Ana P.S.
Molin, Anamaria Dal
Puker, Anderson
Morandini, André C.
Ferreira, André da S.
Martins, André L.
Esteves, André M.
Fernandes, André S.
Roza, André S.
Köhler, Andreas
Paladini, Andressa
Andrade, Andrey J. de
Pinto, Ângelo P.
Salles, Anna C. de A.
Gondim, Anne I.
Amaral, Antonia C.Z.
Rondón, Antonio A.A.
Brescovit, Antonio
Lofego, Antônio C.
Marques, Antonio C.
Macedo, Antonio
Andriolo, Artur
Henriques, Augusto L.
Ferreira Júnior, Augusto L.
Lima, Aurino F. de
Barros, Ávyla R. de A.
Brito, Ayrton do R.
Romera, Bárbara L.V.
Vasconcelos, Beatriz M.C. de
Frable, Benjamin W.
Santos, Bernardo F.
Ferraz, Bernardo R.
Rosa, Brunno B.
Sampaio, Brunno H.L.
Bellini, Bruno C.
Clarkson, Bruno
Oliveira, Bruno G. de
Corrêa, Caio C.D.
Martins, Caleb C.
Castro-Guedes, Camila F. de
Souto, Camilla
Bicho, Carla de L.
Cunha, Carlo M.
Barboza, Carlos A. de M.
Lucena, Carlos A.S. de
Barreto, Carlos
Santana, Carlos D.C.M. de
Agne, Carlos E.Q.
Mielke, Carlos G.C.
Caetano, Carlos H.S.
Flechtmann, Carlos H.W.
Lamas, Carlos J.E.
Rocha, Carlos
Mascarenhas, Carolina S.
Margaría, Cecilia B.
Waichert, Cecilia
Digiani, Celina
Haddad, Célio F.B.
Azevedo, Celso O.
Benetti, Cesar J.
Santos, Charles M.D. dos
Bartlett, Charles R.
Bonvicino, Cibele
Ribeiro-Costa, Cibele S.
Santos, Cinthya S.G.
Justino, Cíntia E.L.
Canedo, Clarissa
Bonecker, Claudia C.
Santos, Cláudia P.
Carvalho, Claudio J.B. de
Gonçalves, Clayton C.
Galvão, Cleber
Costa, Cleide
Oliveira, Cléo D.C. de
Schwertner, Cristiano F.
Andrade, Cristiano L.
Pereira, Cristiano M.
Sampaio, Cristiano
Dias, Cristina de O.
Lucena, Daercio A. de A.
Manfio, Daiara
Amorim, Dalton de S.
Queiroz, Dalva L. de
Queiroz, Dalva L. de
Colpani, Daniara
Abbate, Daniel
Aquino, Daniel A.
Burckhardt, Daniel
Cavallari, Daniel C.
Prado, Daniel de C. Schelesky
Praciano, Daniel L.
Basílio, Daniel S.
Bená, Daniela de C.
Toledo, Daniela G.P. de
Takiya, Daniela M.
Fernandes, Daniell R.R.
Ament, Danilo C.
Cordeiro, Danilo P.
Silva, Darliane E.
Pollock, Darren A.
Muniz, David B.
Gibson, David I.
Nogueira, David S.
Marques, Dayse W.A.
Lucatelli, Débora
Garcia, Deivys M.A.
Baêta, Délio
Ferreira, Denise N.M.
Rueda-Ramírez, Diana
Fachin, Diego A.
Souza, Diego de S.
Rodrigues, Diego F.
Pádua, Diego G. de
Barbosa, Diego N.
Dolibaina, Diego R.
Amaral, Diogo C.
Chandler, Donald S.
Maccagnan, Douglas H.B.
Caron, Edilson
Carvalho, Edrielly
Adriano, Edson A.
Abreu Júnior, Edson F. de
Pereira, Edson H.L.
Viegas, Eduarda F.G.
Carneiro, Eduardo
Colley, Eduardo
Eizirik, Eduardo
Santos, Eduardo F. dos
Shimbori, Eduardo M.
Suárez-Morales, Eduardo
Arruda, Eliane P. de
Chiquito, Elisandra A.
Lima, Élison F.B.
Castro, Elizeu B. de
Orlandin, Elton
Nascimento, Elynton A. do
Razzolini, Emanuel
Gama, Emanuel R.R.
Araujo, Enilma M. de
Nishiyama, Eric Y.
Spiessberger, Erich L.
Santos, Érika C.L. dos
Contreras, Eugenia F.
Galati, Eunice A.B.
Oliveira Junior, Evaldo C. de
Gallardo, Fabiana
Hernandes, Fabio A.
Lansac-Tôha, Fábio A.
Pitombo, Fabio B.
Dario, Fabio Di
Santos, Fábio L. dos
Mauro, Fabio
Nascimento, Fabio O. do
Olmos, Fabio
Amaral, Fabio R.
Schunck, Fabio
Godoi, Fábio S. P. de
Machado, Fabrizio M.
Barbo, Fausto E.
Agrain, Federico A.
Ribeiro, Felipe B.
Moreira, Felipe F.F.
Barbosa, Felipe F.
Silva, Fenanda S.
Cavalcanti, Fernanda F.
Straube, Fernando C.
Carbayo, Fernando
Carvalho Filho, Fernando
Zanella, Fernando C.V.
Jacinavicius, Fernando de C.
Farache, Fernando H.A.
Leivas, Fernando
Dias, Fernando M.S.
Mantellato, Fernando
Vaz-de-Mello, Fernando Z.
Gudin, Filipe M.
Albuquerque, Flávio
Molina, Flavio B.
Passos, Flávio D.
Shockley, Floyd W.
Pinheiro, Francielly F.
Mello, Francisco de A.G. de
Nascimento, Francisco E. de L.
Franco, Francisco L.
Oliveira, Francisco L. de
Melo, Francisco T. de V.
Quijano, Freddy R.B.
Salles, Frederico F.
Biffi, Gabriel
Queiroz, Gabriel C.
Bizarro, Gabriel L.
Hrycyna, Gabriela
Leviski, Gabriela
Powell, Gareth S.
Santos, Geane B. dos
Morse, Geoffrey E.
Brown, George
Mattox, George M.T.
Zimbrão, Geraldo
Carvalho, Gervásio S.
Miranda, Gil F.G.
Moraes, Gilberto J. de
Lourido, Gilcélia M.
Neves, Gilmar P.
Moreira, Gilson R.P.
Montingelli, Giovanna G.
Maurício, Giovanni N.
Marconato, Gláucia
Lopez, Guilherme E.L.
Silva, Guilherme L. da
Muricy, Guilherme
Brito, Guilherme R.R.
Garbino, Guilherme S.T.
Flores, Gustavo E.
Graciolli, Gustavo
Libardi, Gustavo S.
Proctor, Heather C.
Gil-Santana, Helcio R.
Varella, Henrique R.
Escalona, Hermes E.
Schmitz, Hermes J.
Rodrigues, Higor D.D.
Galvão Filho, Hilton de C.
Quintino, Hingrid Y.S.
Pinto, Hudson A.
Rainho, Hugo L.
Miyahira, Igor C.
Gonçalves, Igor de S.
Martins, Inês X.
Cardoso, Irene A.
Oliveira, Ismael B. de
Franz, Ismael
Fernandes, Itanna O.
Golfetti, Ivan F.
S. Campos-Filho, Ivanklin
Oliveira, Ivo de S.
Delabie, Jacques H.C.
Oliveira, Jader de
Prando, Jadila S.
Patton, James L.
Bitencourt, Jamille de A.
Silva, Janaina M.
Santos, Jandir C.
Arruda, Janine O.
Valderrama, Jefferson S.
Dalapicolla, Jeronymo
Oliveira, Jéssica P.
Hájek, Jiri
Morselli, João P.
Narita, João P.
Martin, João P.I.
Grazia, Jocélia
McHugh, Joe
Cherem, Jorge J.
Farias Júnior, José A.S.
Fernandes, Jose A.M.
Pacheco, José F.
Birindelli, José L.O.
Rezende, José M.
Avendaño, Jose M.
Duarte, José M. Barbanti
Ribeiro, José R. Inácio
Mermudes, José R.M.
Pujol-Luz, José R.
Santos, Josenilson R. dos
Câmara, Josenir T.
Teixeira, Joyce A.
Prado, Joyce R. do
Botero, Juan P.
Almeida, Julia C.
Kohler, Julia
Gonçalves, Julia P.
Beneti, Julia S.
Donahue, Julian P.
Alvim, Juliana
Almeida, Juliana C.
Segadilha, Juliana L.
Wingert, Juliana M.
Barbosa, Julianna F.
Ferrer, Juliano
Santos, Juliano F. dos
Kuabara, Kamila M.D.
Nascimento, Karine B.
Schoeninger, Karine
Campião, Karla M.
Soares, Karla
Zilch, Kássia
Barão, Kim R.
Teixeira, Larissa
Sousa, Laura D. do N.M. de
Dumas, Leandro L.
Vieira, Leandro M.
Azevedo, Leonardo H.G.
Carvalho, Leonardo S.
Souza, Leonardo S. de
Rocha, Leonardo S.G.
Bernardi, Leopoldo F.O.
Vieira, Letícia M.
Johann, Liana
Salvatierra, Lidianne
Oliveira, Livia de M.
Loureiro, Lourdes M.A. El-moor
Barreto, Luana B.
Barros, Luana M.
Lecci, Lucas
Camargos, Lucas M. de
Lima, Lucas R.C.
Almeida, Lucia M.
Martins, Luciana R.
Marinoni, Luciane
Moura, Luciano de A.
Lima, Luciano
Naka, Luciano N.
Miranda, Lucília S.
Salik, Lucy M.
Bezerra, Luis E.A.
Silveira, Luis F.
Campos, Luiz A.
Castro, Luiz A.S. de
Pinho, Luiz C.
Silveira, Luiz F.L.
Iniesta, Luiz F.M.
Tencatt, Luiz F.C.
Simone, Luiz R.L.
Malabarba, Luiz R.
Cruz, Luiza S. da
Sekerka, Lukas
Barros, Lurdiana D.
Santos, Luziany Q.
Skoracki, Maciej
Correia, Maira A.
Uchoa, Manoel A.
Andrade, Manuella F.G.
Hermes, Marcel G.
Miranda, Marcel S.
Araújo, Marcel S. de
Monné, Marcela L.
Labruna, Marcelo B.
Santis, Marcelo D. de
Duarte, Marcelo
Knoff, Marcelo
Nogueira, Marcelo
Britto, Marcelo R. de
Melo, Marcelo R.S. de
Carvalho, Marcelo R. de
Tavares, Marcelo T.
Kitahara, Marcelo V.
Justo, Marcia C.N.
Botelho, Marcia J.C.
Couri, Márcia S.
Borges-Martins, Márcio
Felix, Márcio
Oliveira, Marcio L. de
Bologna, Marco A.
Gottschalk, Marco S.
Tavares, Marcos D.S.
Lhano, Marcos G.
Bevilaqua, Marcus
Santos, Marcus T.T.
Domingues, Marcus V.
Sallum, Maria A.M.
Digiani, María C.
Santarém, Maria C.A.
Nascimento, Maria C. do
Becerril, María de los A.M.
Santos, Maria E.A. dos
Passos, Maria I. da S. dos
Felippe-Bauer, Maria L.
Cherman, Mariana A.
Terossi, Mariana
Bartz, Marie L.C.
Barbosa, Marina F. de C.
Loeb, Marina V.
Cohn-Haft, Mario
Cupello, Mario
Martins, Marlúcia B.
Christofersen, Martin L.
Bento, Matheus
Rocha, Matheus dos S.
Martins, Maurício L.
Segura, Melissa O.
Cardenas, Melissa Q.
Duarte, Mércia E.
Ivie, Michael A.
Mincarone, Michael M.
Borges, Michela
Monné, Miguel A.
Casagrande, Mirna M.
Fernandez, Monica A.
Piovesan, Mônica
Menezes, Naércio A.
Benaim, Natalia P.
Reategui, Natália S.
Pedro, Natan C.
Pecly, Nathalia H.
Ferreira Júnior, Nelson
Silva Júnior, Nelson J. da
Perioto, Nelson W.
Hamada, Neusa
Degallier, Nicolas
Chao, Ning L.
Ferla, Noeli J.
Mielke, Olaf H.H.
Evangelista, Olivia
Shibatta, Oscar A.
Oliveira, Otto M.P.
Albornoz, Pablo C.L.
Dellapé, Pablo M.
Gonçalves, Pablo R.
Shimabukuro, Paloma H.F.
Grossi, Paschoal
Rodrigues, Patrícia E. da S.
Lima, Patricia O.V.
Velazco, Paul
Santos, Paula B. dos
Araújo, Paula B.
Silva, Paula K.R.
Riccardi, Paula R.
Garcia, Paulo C. de A.
Passos, Paulo G.H.
Corgosinho, Paulo H.C.
Lucinda, Paulo
Costa, Paulo M.S.
Alves, Paulo P.
Roth, Paulo R. de O.
Coelho, Paulo R.S.
Duarte, Paulo R.M.
Carvalho, Pedro F. de
Gnaspini, Pedro
Souza-Dias, Pedro G.B.
Linardi, Pedro M.
Bartholomay, Pedro R.
Demite, Peterson R.
Bulirsch, Petr
Boll, Piter K.
Pereira, Rachel M.M.
Silva, Rafael A.P.F.
Moura, Rafael B. de
Boldrini, Rafael
Silva, Rafaela A. da
Falaschi, Rafaela L.
Cordeiro, Ralf T.S.
Mello, Ramon J.C.L.
Singer, Randal A.
Querino, Ranyse B.
Heleodoro, Raphael A.
Castilho, Raphael de C.
Constantino, Reginaldo
Guedes, Reinaldo C.
Carrenho, Renan
Gomes, Renata S.
Gregorin, Renato
Machado, Renato J.P.
Bérnils, Renato S.
Capellari, Renato S.
Silva, Ricardo B.
Kawada, Ricardo
Dias, Ricardo M.
Siewert, Ricardo
Brugnera, Ricaro
Leschen, Richard A.B.
Constantin, Robert
Robbins, Robert
Pinto, Roberta R.
Reis, Roberto E. dos
Ramos, Robson T. da C.
Cavichioli, Rodney R.
Barros, Rodolfo C. de
Caires, Rodrigo A.
Salvador, Rodrigo B.
Marques, Rodrigo C.
Araújo, Rodrigo C.
Araujo, Rodrigo de O.
Dios, Rodrigo de V.P.
Johnsson, Rodrigo
Feitosa, Rodrigo M.
Hutchings, Roger W.
Lara, Rogéria I.R.
Rossi, Rogério V.
Gerstmeier, Roland
Ochoa, Ronald
Hutchings, Rosa S.G.
Ale-Rocha, Rosaly
Rocha, Rosana M. da
Tidon, Rosana
Brito, Rosangela
Pellens, Roseli
Santos, Sabrina R. dos
Santos, Sandra D. dos
Paiva, Sandra V.
Santos, Sandro
Oliveira, Sarah S. de
Costa, Sávio C.
Gardner, Scott L.
Leal, Sebastián A. Muñoz
Aloquio, Sergio
Bonecker, Sergio L.C.
Bueno, Sergio L. de S.
Almeida, Sérgio M. de
Stampar, Sérgio N.
Andena, Sérgio R.
Posso, Sergio R.
Lima, Sheila P.
Gadelha, Sian de S.
Thiengo, Silvana C.
Cohen, Simone C.
Brandão, Simone N.
Rosa, Simone P.
Ribeiro, Síria L.B.
Letana, Sócrates D.
Santos, Sonia B. dos
Andrade, Sonia C.S.
Dávila, Stephane
Vaz, Stéphanie
Peck, Stewart B.
Christo, Susete W.
Cunha, Suzan B.Z.
Gomes, Suzete R.
Duarte, Tácio
Madeira-Ott, Taís
Marques, Taísa
Roell, Talita
Lima, Tarcilla C. de
Sepulveda, Tatiana A.
Maria, Tatiana F.
Ruschel, Tatiana P.
Rodrigues, Thaiana
Marinho, Thais A.
Almeida, Thaís M. de
Miranda, Thaís P.
Freitas, Thales R.O.
Pereira, Thalles P.L.
Zacca, Thamara
Pacheco, Thaynara L.
Martins, Thiago F.
Alvarenga, Thiago M.
Carvalho, Thiago R. de
Polizei, Thiago T.S.
McElrath, Thomas C.
Henry, Thomas
Pikart, Tiago G.
Porto, Tiago J.
Krolow, Tiago K.
Carvalho, Tiago P.
Lotufo, Tito M. da C.
Caramaschi, Ulisses
Pinheiro, Ulisses dos S.
Pardiñas, Ulyses F.J.
Maia, Valéria C.
Tavares, Valeria
Costa, Valmir A.
Amaral, Vanessa S. do
Silva, Vera C.
Wolff, Vera R. dos S.
Slobodian, Verônica
Silva, Vinícius B. da
Espíndola, Vinicius C.
Costa-Silva, Vinicius da
Bertaco, Vinicius de A.
Padula, Vinícius
Ferreira, Vinicius S.
Silva, Vitor C.P. da
Piacentini, Vítor de Q.
Sandoval-Gómez, Vivian E.
Trevine, Vivian
Sousa, Viviane R.
Sant’Anna, Vivianne B. de
Mathis, Wayne N.
Souza, Wesley de O.
Colombo, Wesley D.
Tomaszewska, Wioletta
Wosiacki, Wolmar B.
Ovando, Ximena M.C.
Leite, Yuri L.R.








ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
4.
In silico and in vitro Studies Evaluating the Promising Antiureolytic Activity of Schiff’s Base 4-(3-Hydroxybenzylideneamino)phenol and Its Amine Derivative Schiffs Schiff s 43Hydroxybenzylideneaminophenol Hydroxybenzylideneaminophenol 4 3 Hydroxybenzylideneamino phenol
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Dohanik, Caroline S.
; Pereira, Camila P.
; Oliveira, Breno G. F. de
; Nascimento, Igor J. S.
; Nascimento, Amanda Luise A.
Santos, Josué C. C.
Aquino, Thiago M. de
Castilho, Rachel O.
Modolo, Luzia V.
Fátima, Ângelo de
Goulart, Gisele A. C.




Journal of the Brazilian Chemical Society
- Métricas do periódico
Urea is the most widely used nitrogen fertilizer worldwide. However, ammonia volatilization, resulting from applying urea to the soil surface, causes economic and environmental losses; thus, urease inhibitors have been developed to mitigate these losses. In this work, the anti-ureolytic activity of Schiff’s base 4-(3-hydroxybenzylideneamino) phenol (3B4) and its amine-derived (3B4a) was evaluated. The most promising urease inhibitor in soil was 3B4 (55.0 ± 3.9% inhibition), with comparable results to N-(butyl) thiophosphoric triamide (p = 0.659). In the in vitro analysis (Canavalia ensiformis), the results of anti-ureolytic activity were similar, 22.6 ± 6.9% for 3B4 and 24.2 ± 9.6% for 3B4a. Biophysical interaction studies were also carried out through molecular docking studies and molecular fluorescence spectroscopy. These studies showed that both substances are preferentially competitive inhibitors, with the interaction between 3B4a and urease forming a more stable complex. In the analysis by Fourier transform infrared spectroscopy, no interaction was observed when 3B4 or 3B4a was mixed with urea (1:1) for 48 h, providing evidence of compatibility. Thus, the Schiff base 3B4 and its corresponding amine 3B4a may represent potential additives for urea fertilization aiming to assist in the urease inhibition process. worldwide However volatilization surface losses thus work antiureolytic anti ureolytic Schiffs s 43hydroxybenzylideneamino hydroxybenzylideneamino 4 3 4-(3-hydroxybenzylideneamino B (3B4 aminederived derived Ba (3B4a evaluated 3B 55.0 550 55 0 (55. 39 9 3.9 inhibition, , inhibition) Nbutyl N butyl N-(butyl p 0.659. 0659 0.659 . 659 0.659) Canavalia ensiformis, ensiformis ensiformis) similar 226 22 6 22. 69 6.9 242 24 2 24. 96 9.6 spectroscopy complex 11 1 (1:1 h compatibility Thus process (3B 55. 5 (55 3. 065 0.65 65 6. 9. (1: (5 06 0.6 (1 ( 0.
5.
White Shark or Shortfin Mako? Lamnid sharks identification in an overlapping area of the Equatorial Southwestern Atlantic Mako
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Gonçalves-Neto, José Belquior
; Lima, Camila de França
; Jucá-Queiroz, Bruno
; Freitas, João Eduardo Pereira de
; Charvet, Patricia
; Faria, Vicente Vieira
.






Abstract Despite their worldwide distribution, the occurrence of Lamnidae species in tropical zones remain poorly understood. In the Equatorial Southwestern Atlantic, the Shortfin Mako, Isurus oxyrinchus , has been captured in commercial fisheries, whereas the White Shark, Carcharodon carcharias , is only rarely recorded. This study aimed to characterize lamnid records for the Equatorial Southwestern Atlantic, as well as to apply molecular markers to identify a lamnid carcass from the only area in the region where these two species are known to overlap (off Ceará State, Northeastern Brazil). The landed carcass, although sold in the market as a White Shark, in fact was a Shortfin Mako, I. oxyrinchus , with a total of 99.6% and 100% match to its ND2 and D-loop mitochondrial DNA sequences, respectively. Despite the existence of a record of landings of elasmobranchs by artisanal and commercial fisheries from Ceará, lamnid landings in this region are still rare and comprise only four records for I. oxyrinchus , including juvenile specimens. As for the White Shark, Ceará State remains the only region in the Equatorial Southwestern Atlantic to hold records (three) of C. carcharias (all of them adults). Oceanographic conditions in this region may contribute to the occasional presence of large lamnid specimens. Moreover, fishers seem to support the presence of both lamnid species in the region. distribution understood Mako Shark recorded off Brazil. Brazil . Brazil) I 996 99 6 99.6 100 ND Dloop D loop sequences respectively specimens three (three C all adults. adults adults) Moreover 9 99. 10 1
6.
Water masses drive the spatial and temporal distribution of marine Archaea in the northern Antarctic Peninsula
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Anais da Academia Brasileira de Ciências
- Métricas do periódico
Abstract The Southern Ocean influences the planet’s biogeochemical cycles. Marine microorganisms are important in this scenario, being the main biological agents in the cycling of many elements. The Archaea domain is widely distributed in the oceans, and its presence in Antarctica is acknowledged. In this context, this work aimed to analyze the diversity and distribution of archaea according to environmental parameters in the waters surrounding the north of the Antarctic Peninsula. For environmental characterization studies, surface and bottom data were used for the ten monitoring stations of expeditions that took place in the summer of 2014 and 2015. The sequencing of the 16S rRNA gene was performed on the Illumina HiSeq platform, using the SILVA v138 database. The results revealed the presence of three main water bodies: Antarctic Surface Water, Shelf Waters, and modified Circumpolar Deep Water. Deep waters had higher diversity than surface waters, and the dominant groups were Nitrososphaeria and MGII. In the study region, the main factor responsible for the differences in the ecosystems was the presence of distinct water masses and the stratification of the water column. We argue that it is essential to consider water mass dynamics to study the microbial landscape of the Southern Ocean. planets planet s cycles scenario elements oceans acknowledged context Peninsula studies 201 2015 S platform v v13 database bodies Water Waters MGII region column 20 v1 2
7.
Effect of Substrate Preparation and the Conversion Coating on the Corrosion Resistance in Ringer's Solution of 304L Stainless Steel Coated with Alumina Film Ringers Ringer s L
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Pereira, Carlos M. S.
; Silva, Gustavo F.
; Diniz, Marília G.
Silva, Camila S.
Braga, Antônio V. C.
Senna, Lilian F. de


This work aims to determine the best substrate preparation and conversion coatings that may enhance the anti-corrosive performance of alumina film/stainless steel substrate systems in Ringer’s solution. Boehmite, silica, silica/boehmite, and boehmite/silica conversion coatings were deposited on sanded or sandblasted 304L stainless steel samples, and the best results were further covered with alumina film for a long-time exposure evaluation. The best anti-corrosive performances for each substrate preparation were observed for the sandblasted sample covered with silica/boehmite conversion coating (JSB500) and the sanded sample covered with silica (LS500), which showed the highest global resistance (Rg) values (828 Ω.cm2 and 1837 Ω.cm2, respectively) and the smallest values of global capacitance, Cg (2.19 X 10-6 F.cm-2 and 3.37 X 10-9 F.cm-2, respectively). After covering with the alumina film and evaluating for 216 h in the corrosive medium, it was noted an increase in the Rg values for both systems (JSBA500 and LSBA500), likely due to the presence of a corrosion products layer. The presence of iron oxides in these conversion coatings led to a more stable alumina film. Comparing the selected coating systems, the LSBA500 exhibited an improved performance, reaching an increase of 85% in Rg and a decrease of 94% in Cg. anticorrosive anti filmstainless Ringers Ringer s solution Boehmite silicaboehmite boehmite boehmitesilica L samples longtime long time evaluation JSB500 JSB (JSB500 LS500, LS500 LS , (LS500) (Rg 828 (82 Ωcm2 Ωcm Ω cm2 cm Ω.cm 183 respectively capacitance 2.19 219 2 19 (2.1 106 10 6 10- F.cm2 Fcm2 Fcm F.cm F F.cm- 337 3 37 3.3 109 9 F.cm2, 2, respectively. . 21 medium JSBA500 JSBA (JSBA50 LSBA500, LSBA LSBA500) layer LSBA50 85 94 JSB50 (JSB50 LS50 (LS500 82 (8 18 2.1 1 (2. 33 3. JSBA50 (JSBA5 LSBA5 8 JSB5 (JSB5 LS5 (LS50 ( 2. (2 JSBA5 (JSBA (JSB (LS5 (LS
8.
Warminins A, B and C, Three New Furofuran Lignans from Aristolochia warmingii Mast. (Aristolochiaceae)
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Cunha, Camila L.
; Antonio, Paulo Vinícius G. de
; Lustosa, Maria do Carmo G.
; Cruz, Állefe B.
Holzbach, Juliana C.
Pereira, Douglas H.
Nascimento, Isabele R.



Journal of the Brazilian Chemical Society
- Métricas do periódico
The genus Aristolochia stands out as the most representative of the Aristolochiaceae plant family, with approximately 550 species distributed around the world, many of which have little or no studies reported in the literature. Investigation of the acetone extract from leaves of Aristolochia warmingii Mast. resulted in the isolation and identification of twenty-three compounds, mostly lignans and neolignans, including the new furofuran lignans warminin A (1), warminin B (2) and warminin C (3). The structures of the compounds were established by comprehensive spectroscopic and spectrometric analyses. A large amount of (–)-epieudesmin (4) was isolated from the extract, which suggests that A. warmingii could be a potential source of this compound. The hexane, acetone, ethanol, and ethanol Soxhlet extracts, in addition to fourteen of the isolated compounds, were evaluated for their ability to inhibit the formation of advanced glycation end products (AGEs), but they did not show significant activities.
9.
Exchange of germoplasm and genetic diversity to enrichment the Desmanthus genebank
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Silva, Ana V. C. da
; Nascimento, Isa M. R. do
; Rangel, José H. A.
; Pereira, Camila S. A.
; Muniz, Evandro N.
.





RESUMO O gênero Desmanthus apresenta ampla distribuição ecogeográfica e complexa taxonomia. O Desmanthus pernambucanus (L.) Thellung, popularmente conhecido como Jureminha, é uma leguminosa nativa do Nordeste brasileiro, que se destaca pelo elevado teor de proteína, resistência à seca e por não apresentar toxicidade aos animais. O trabalho foi desenvolvido com o objetivo de avaliar a diversidade genética de 15 progênies oriundas do CSIRO (Commonwealth Scientific and Industrial Research Organization, Austrália), através de intercâmbio de germoplasma, para o enriquecimento do Banco Ativo de Germoplasma de Desmanthus da Embrapa Tabuleiros Costeiros (BAG), em Nossa Senhora das Dores, SE, Brasil. Foram utilizados 15 marcadores ISSR, dos quais oito foram selecionados. As progênies identificadas como 242, 245, 246, 255 e 268 foram as mais distantes geneticamente, e as mais indicadas para serem introduzidas no BAG. taxonomia L. L (L. Thellung Jureminha brasileiro proteína animais 1 Commonwealth Organization Austrália, Austrália , Austrália) germoplasma BAG, BAG (BAG) Dores SE Brasil ISSR selecionados 242 245 246 25 26 geneticamente (L (BAG 24 2
ABSTRACT The genus Desmanthus presents wide ecogeographical distribution and complex taxonomy. Desmanthus pernambucanus (L.) Thellung, popularly known in Brazil as Jureminha, is a leguminous species native to the Northeast region of Brazil, which stands out by its high protein content, resistance to droughts, and by presenting no toxicity to animals. The objective of this work was to evaluate the genetic diversity of 15 progenies from the Commonwealth Scientific and Industrial Research Organization (CSIRO; Australia), through germplasm exchange for enrichment of the Desmanthus genebank of Embrapa Tabuleiros Costeiros, in Nossa Senhora das Dores, SE, Brazil. Fifteen ISSR markers were used, from which 8 were selected. The progenies identified as 242, 245, 246, 255, and 268 were the most genetically distant, and the most recommended to be introduced to the genebank. taxonomy L. L (L. Thellung Jureminha content droughts animals 1 CSIRO (CSIRO Australia, Australia , Australia) Costeiros Dores SE used selected 242 245 246 255 26 distant (L 24 25 2
10.
Performance of glyphosate-based products applied alone and in combination with herbicides in burndown
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Pereira, Bruno C. S.
; Braz, Guilherme B. P.
; Souza, Matheus de F.
; Reginaldo, Laís T. R. T.
; Ferreira, Camila J. B.
.





ABSTRACT The no-tillage system is a conservation system that helps sustainability and agricultural production. The effectiveness of glyphosate control, applied alone or in combination with other herbicides, can be altered depending on the product’s formulation. The objective of the present study was to evaluate the effectiveness of glyphosate in formulations containing different salts and concentrations, applied alone and in combination with other herbicides, in controlling weeds in advanced stages in the pre-sowing burndown operation. The experiment was carried out in the field in an area with a history of high weed infestation. The experiment was conducted in a randomized block design, evaluating eleven treatments and four replicates. The treatments consisted of the application of three glyphosate-based formulations alone and in combination with clethodim and 2,4-D amine herbicides, in addition to a control without herbicide application. The evaluated variables were percentage of weed control and percentage of desiccation. A comparison of means by contrasts was performed to analyze the percentage of weed control. In general, treatments containing products based on glyphosate potassium salt in the composition have slightly better control performance compared to those consisting of glyphosate isopropylamine salt.
RESUMO O sistema de plantio direto é um sistema conservacionista que auxilia na sustentabilidade e a produção agrícola. A eficácia de controle do glyphosate, aplicado isoladamente ou em associação a outros herbicidas, pode ser alterada em função da formulação do produto. O objetivo do presente trabalho foi avaliar a eficácia de glyphosate em formulações contendo diferentes sais e concentrações, aplicado isolado e em associações a outros herbicidas, no controle de plantas daninhas em estádios avançados na operação de dessecação pré-semeadura. O experimento foi realizado a campo em área com histórico de elevada infestação de plantas daninhas. O experimento foi conduzido no delineamento de blocos casualizados, avaliando-se onze tratamentos e quatro repetições. Os tratamentos foram compostos pela aplicação de três formulações à base de glyphosate isolado e em associações com os herbicidas clethodim e 2,4-D amina, além de uma testemunha sem aplicação. As variáveis avaliadas foram porcentagem de controle das plantas daninhas e porcentagem de dessecação. Foi realizado uma comparação de médias por contrastes para analisar a porcentagem de controle de plantas daninhas. De maneira geral, tratamentos contendo produtos à base de glyphosate sal potássico na composição apresentam performance de controle ligeiramente superior em comparação com àqueles constituídos por glyphosate sal de isopropilamina.
11.
2-(Pyridin-4yl)benzothiazole and Its Benzimidazole-Analogue: Biophysical and in silico Studies on Their Interaction with Urease and in vitro Anti-Helicobacter pylori Activities
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Pereira, Camila P.
; Lyra, Ana C. F. de
; Oliveira, Breno G. F.
; Nascimento, Igor J. S.
Silva-Júnior, Edeildo F. da
Aquino, Thiago M. de
Sisto, Francesca
Figueiredo, Isis M.
Martins, Felipe T.
Modolo, Luzia V.
Santos, Josué C. C.
Fátima, Ângelo de



Journal of the Brazilian Chemical Society
- Métricas do periódico
In this study, the interaction between benzothiazole (BTA, concentration of a drug required for 50% inhibition in vitro (IC50) = 0.77 mM) and benzimidazole (BIA, IC50 = 2.14 mM) with urease was quantitatively assessed, using UV-Vis, molecular fluorescence, and circular dichroism. The results showed that both compounds interact with urease by a static fluorescence quenching mechanism with a non-fluorescent complex formation. The main forces responsible for stabilizing the supramolecular complex between BTA and urease were hydrophobic while, for BIA, van der Waals interactions and hydrogen bonds were the main ones. Urease conformation changes due to the interaction process were analyzed by circular dichroism and synchronous fluorescence. Besides, a competitive assay with substrate and inhibitors was used to evaluate the preferential urease site of interaction with BTA and BIA. Our experimental and theoretical studies supported that both, BTA and BIA, are mixed-inhibitors of ureases with a slight preference to the active site of such enzymes. Finally, both BTA and BIA showed to possess anti-Helicobacter pylori (one reference strain and six clinical isolates) activity, presenting minimal inhibitory concentration (MIC) values ranging from 38-150 and 20-164 µM, respectively. The urease inhibitors omeprazole and hydroxyurea showed MIC values in the range of 46-185 µM and 1683-> 3366 µM, respectively.
12.
Differentials in death count records by databases in Brazil in 2010
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Diógenes, Victor Hugo Dias
; Pinto Júnior, Elzo Pereira
; Gonzaga, Marcos Roberto
; Queiroz, Bernardo Lanza
; Lima, Everton E. C.
; Costa, Lilia Carolina C. da
; Rocha, Aline S.
; Ferreira, Andrêa J. F.
; Teixeira, Camila S. S.
; Alves, Flávia Jôse O.
; Rameh, Leila
; Flores-Ortiz, Renzo
; Leyland, Alastair
; Dundas, Ruth
; Barreto, Maurício L.
; Ichihara, Maria Yury Travassos
.
















ABSTRACT OBJECTIVE To compare the death counts from three sources of information on mortality available in Brazil in 2010, the Mortality Information System (SIM - Sistema de Informações sobre Mortalidade ), Civil Registration Statistic System (RC - Sistema de Estatísticas de Resgistro Civil ), and the 2010 Demographic Census at various geographical levels, and to confirm the association between municipal socioeconomic characteristics and the source which showed the highest death count. METHODS This is a descriptive and comparative study of raw data on deaths in the SIM, RC and 2010 Census databases, the latter held in Brazilian states and municipalities between August 2009 and July 2010. The percentage of municipalities was confirmed by the database showing the highest death count. The association between the source of the highest death count and socioeconomic indicators - the Índice de Privação Brasileiro (IBP – Brazilian Deprivation Index) and Índice de Desenvolvimento Humano Municipal (IHDM – Municipal Human Development Index) - was performed by bivariate choropleth and Moran Local Index of Spatial Association (LISA) cluster maps. RESULTS Confirmed that the SIM is the database with the highest number of deaths counted for all Brazilian macroregions, except the North, in which the highest coverage was from the 2010 Census. Based on the indicators proposed, in general, the Census showed a higher coverage of deaths than the SIM and the RC in the most deprived (highest IBP values) and less developed municipalities (lowest IDHM values) in the country. CONCLUSION The results highlight regional inequalities in how the databases chosen for this study cover death records, and the importance of maintaining the issue of mortality on the basic census questionnaire.
13.
Mortality inequalities measured by socioeconomic indicators in Brazil: a scoping review
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Ichihara, Maria Yury
; Ferreira, Andrêa J.F.
; Teixeira, Camila S. S.
; Alves, Flávia Jôse O.
; Rocha, Aline Santos
; Diógenes, Victor Hugo Dias
; Ramos, Dandara Oliveira
; Pinto Júnior, Elzo Pereira
; Flores-Ortiz, Renzo
; Rameh, Leila
; Costa, Lilia Carolina C. da
; Gonzaga, Marcos Roberto
; Lima, Everton E. C.
; Dundas, Ruth
; Leyland, Alastair
; Barreto, Maurício L.
.
















ABSTRACT OBJECTIVE Summarize the literature on the relationship between composite socioeconomic indicators and mortality in different geographical areas of Brazil. METHODS This scoping review included articles published between January 1, 2000, and August 31, 2020, retrieved by means of a bibliographic search carried out in the Medline, Scopus, Web of Science, and Lilacs databases. Studies reporting on the association between composite socioeconomic indicators and all-cause, or specific cause of death in any age group in different geographical areas were selected. The review summarized the measures constructed, their associations with the outcomes, and potential study limitations. RESULTS Of the 77 full texts that met the inclusion criteria, the study reviewed 24. The area level of composite socioeconomic indicators analyzed comprised municipalities (n = 6), districts (n = 5), census tracts (n = 4), state (n = 2), country (n = 2), and other areas (n = 5). Six studies used composite socioeconomic indicators such as the Human Development Index, Gross Domestic Product, and the Gini Index; the remaining 18 papers created their own socioeconomic measures based on sociodemographic and health indicators. Socioeconomic status was inversely associated with higher rates of all-cause mortality, external cause mortality, suicide, homicide, fetal and infant mortality, respiratory and circulatory diseases, stroke, infectious and parasitic diseases, malnutrition, gastroenteritis, and oropharyngeal cancer. Higher mortality rates due to colorectal cancer, leukemia, a general group of neoplasms, traffic accident, and suicide, in turn, were observed in less deprived areas and/or those with more significant socioeconomic development. Underreporting of death and differences in mortality coverage in Brazilian areas were cited as the main limitation. CONCLUSIONS Studies analyzed mortality inequalities in different geographical areas by means of composite socioeconomic indicators, showing that the association directions vary according to the mortality outcome. But studies on all-cause mortality and at the census tract level remain scarce. The results may guide the development of new composite socioeconomic indicators for use in mortality inequality analysis.
14.
Antifungal activity of liriodenine on clinical strains of Cryptococcus neoformans and Cryptococcus gattii species complexes
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Levorato-Vinche, Adriele Dandara
; Melhem, Marcia de Souza Carvalho
; Bonfietti, Lucas Xavier
; de-la-Cruz-Chacón, Iván
; Boaro, Carmen Sílvia Fernandes
; Fabro, Alexandre Todorovic
; Ferreira, Gisela
; Silva, Julhiany de Fátima da
; Santos, Daniela Carvalho dos
Pereira, Beatriz Aparecida Soares
Marçon, Camila
Maza, Lariza
Carvalho, Lídia Raquel de
Mendes, Rinaldo Poncio








Journal of Venomous Animals and Toxins including Tropical Diseases
- Métricas do periódico
Abstract Background: Cryptoccocal meningitis continues to present high incidence among AIDS patients. The treatment of choice is the synergistic combination of flucytosine (5-FC) with amphotericin B deoxycholate (AmBd) or its lipid formulations. However, 5-FC is unavailable in many countries and AmB demands hospitalization. The combination of AmB with the fungistatic fluconazole (FLC) or the use of high FLC daily doses alone became the choice. Nonetheless, sterilization of cerebrospinal fluid is delayed with FLC monotherapy, mainly with high fungal burden. These findings suggest the search for new antifungal compounds, such as liriodenine. Methods: Liriodenine antifungal activity was evaluated by three procedures: determining the minimum inhibitory concentration (MIC) on 30 strains of the Cryptococcus neoformans (C. neoformans) complex and 30 of the Cryptococcus gattii (C. gattii) complex, using EUCAST methodology and amphotericin B deoxycholate as control; performing the time-kill methodology in two strains of the C. neoformans complex and one of the C. gattii complex; and injury to cryptococcal cells, evaluated by transmission electron microscopy (TEM). Liriodenine absorption and safety at 0.75 and 1.50 mg.kg-1 doses were evaluated in BALB/c mice. Results: Liriodenine MICs ranged from 3.9 to 62.5 μg.mL-1 for both species complexes, with no differences between them. Time-kill methodology confirmed its concentration-dependent fungicidal effect, killing all the strains below the limit of detection (33 CFU.mL-1) at the highest liriodenine concentration (32-fold MIC), with predominant activity during the first 48 hours. Liriodenine induced severe Cryptococcus alterations - cytoplasm with intense rarefaction and/or degradation, injury of organelles, and presence of vacuoles. Liriodenine was better absorbed at lower doses, with no histopathological alterations on the digestive tract. Conclusion: The fungicidal activity confirmed by time-kill methodology, the intense Cryptococcus injury observed by TEM, the absorption after gavage administration, and the safety at the tested doses indicate that the liriodenine molecule is a promising drug lead for development of anticryptococcal agents.
15.
Mortality inequalities measured by socioeconomic indicators in Brazil: a scoping review
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Ichihara, Maria Yury
; Ferreira, Andrêa J.F.
; Teixeira, Camila S. S.
; Alves, Flávia Jôse O.
; Rocha, Aline Santos
; Diógenes, Victor Hugo Dias
; Ramos, Dandara Oliveira
; Pinto Júnior, Elzo Pereira
; Flores-Ortiz, Renzo
; Rameh, Leila
; Costa, Lilia Carolina C. da
; Gonzaga, Marcos Roberto
; Lima, Everton E. C.
; Dundas, Ruth
; Leyland, Alastair
; Barreto, Maurício L.
.
















ABSTRACT OBJECTIVE Summarize the literature on the relationship between composite socioeconomic indicators and mortality in different geographical areas of Brazil. METHODS This scoping review included articles published between January 1, 2000, and August 31, 2020, retrieved by means of a bibliographic search carried out in the Medline, Scopus, Web of Science, and Lilacs databases. Studies reporting on the association between composite socioeconomic indicators and all-cause, or specific cause of death in any age group in different geographical areas were selected. The review summarized the measures constructed, their associations with the outcomes, and potential study limitations. RESULTS Of the 77 full texts that met the inclusion criteria, the study reviewed 24. The area level of composite socioeconomic indicators analyzed comprised municipalities (n = 6), districts (n = 5), census tracts (n = 4), state (n = 2), country (n = 2), and other areas (n = 5). Six studies used composite socioeconomic indicators such as the Human Development Index, Gross Domestic Product, and the Gini Index; the remaining 18 papers created their own socioeconomic measures based on sociodemographic and health indicators. Socioeconomic status was inversely associated with higher rates of all-cause mortality, external cause mortality, suicide, homicide, fetal and infant mortality, respiratory and circulatory diseases, stroke, infectious and parasitic diseases, malnutrition, gastroenteritis, and oropharyngeal cancer. Higher mortality rates due to colorectal cancer, leukemia, a general group of neoplasms, traffic accident, and suicide, in turn, were observed in less deprived areas and/or those with more significant socioeconomic development. Underreporting of death and differences in mortality coverage in Brazilian areas were cited as the main limitation. CONCLUSIONS Studies analyzed mortality inequalities in different geographical areas by means of composite socioeconomic indicators, showing that the association directions vary according to the mortality outcome. But studies on all-cause mortality and at the census tract level remain scarce. The results may guide the development of new composite socioeconomic indicators for use in mortality inequality analysis.
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