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au:Pereira, Ana Carolina Figueiredo

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Position statement of the Brazilian society of Rheumatology on mesna use as a preventive therapy for bladder disease in patients with systemic autoimmune diseases and systemic vasculitis under cyclophosphamide treatment
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de Souza, Alexandre Wagner S.

; Dantas, João Gabriel

; Montandon, Ana Carolina de Oliveira e Silva

; Calich, Ana Luísa

; Alverne, Andrea Rocha de Saboia Mont'

; Gasparin, Andrese Aline

; Bianchi, Dante

; Yuki, Emily Figueiredo Neves

; Sacilotto, Nathalia

; Reis Neto, Edgard Torres dos

; Monticielo, Odirlei André

; Pereira, Ivanio Alves

Advances in Rheumatology

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2024, Volume 64 elocation 41

Resumo: En | Texto: En | PDF: En

Abstract Objective To review current literature to support the use of mesna as a preventive therapy for hemorrhagic cystitis and bladder cancer in patients with systemic autoimmune diseases and systemic vasculitis treated with cyclophosphamide. Materials and methods The search for articles was conducted systematically through MEDLINE, LILACS, Cochrane Library, and Embase databases. Only articles in English were selected. For available records, titles and abstracts were selected independently by two investigators. Results Eighteen studies were selected for analysis. The known adverse effects of cyclophosphamide were hematological toxicity, infections, gonadal toxicity, teratogenicity, increased risk for malignancy and hemorrhagic cystitis. Long-term toxicity was highly dependent on cyclophosphamide cumulative dose. The risk of bladder cancer is especially higher in long-term exposure and with cumulative doses above 36 g. The risk remains high for years after drug discontinuation. Hemorrhagic cystitis is highly correlated with cumulative dose and its incidence ranges between 12 and 41%, but it seems to be lower with new regimens with reduced cyclophosphamide dose. No randomized controlled trials were found to analyze the use of mesna in systemic autoimmune rheumatic diseases and systemic vasculitis. Retrospective studies yielded conflicting results. Uncontrolled prospective studies with positive results were considered at high risk of bias. No evidence was found to support the use of mesna during the treatment with cyclophosphamide for autoimmune diseases or systemic vasculitis to prevent hemorrhagic cystitis and bladder cancer. In the scenarios of high cumulative cyclophosphamide dose (i.e., > 30 g), patients with restricted fluid intake, neurogenic bladder, therapy with oral anticoagulants, and chronic kidney disease, mesna could be considered. Conclusion The current evidence was found to be insufficient to support the routine use of mesna for the prophylaxis of hemorrhagic cystitis and bladder cancer in patients being treated for systemic autoimmune diseases and systemic vasculitis with cyclophosphamide. The use may be considered for selected cases. MEDLINE LILACS Library databases records investigators analysis infections teratogenicity Longterm Long term longterm long 3 g discontinuation 1 41 41% bias i.e., ie i e (i.e. g, , g) intake anticoagulants disease cases 4 i.e. (i.e i.e

https://doi.org/10.1186/s42358-024-00380-0

Trajetórias Adolescentes e Infração: José, entre a Morte e a Aposta
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Moreira, Jacqueline de Oliveira

; Guerra, Andréa Máris Campos

; Marinho, Frederico Couto

; Silva, Bráulio Figueiredo Alves da

; Rodrigues, Bianca Ferreira

; Silva, Ana Carolina Dias

; Oliveira, Lucas Caetano Pereira de

Psicologia: Ciência e Profissão

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2022, Volume 42 elocation e231908

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Frente às elevadas taxas de mortalidade e encarceramento de jovens brasileiros negros, pobres e moradores de periferia, apresenta-se pesquisa transdisciplinar que buscou qualificar os eventos, transições e rupturas que marcam suas trajetórias, analisando o ciclo de vida para desvelar seus nexos, movimentos e fatores de risco. Para tanto, partimos do levantamento de Planos Individuais de Atendimento (PIA) de adolescentes em cumprimento de medida socioeducativa para, posteriormente, efetuar uma busca ativa por esses sujeitos, a fim de aplicar um questionário e convidá-los a contarem suas histórias de vida por meio da metodologia de Narrativas Memorialísticas. A partir da análise de um caso que revela o potencial universal de cada vida singular, foram analisados quatro eixos identificados a partir do próprio discurso do jovem, a saber: a violência do Estado, a adolescência, a mortalidade e a aposta. Em contraposição à precariedade e à ausência de amparo a que algumas vidas são lançadas, desvelando a morte, uma aposta decidida, traduzida pela oferta de algum enlaçamento, parece convocar a construção de saídas possíveis.

Abstract Considering the high rates of mortality and incarceration among young black Brazilians, the poor, and the periphery residents, we present this transdisciplinary research that sought to qualify the events, transitions, and ruptures that mark their trajectories, analysing their life cycle to unveil its links, movements, and risk factors. We started with the survey of Planos Individuais de Atendimento (Individual Care Plans - PIA) of adolescents in compliance with a socio-educational measure, and later with an active search for these subjects, to apply a questionnaire and invite them to tell their life stories by using the methodology of Narrative Memoir. From a case analysis, which reveals the universal potential of each singular life, we analyzed four axes identified from the young man’s own discourse, namely: State violence, adolescence, mortality, and wager. In contrast to the precariousness and the lack of support in their lives, risking death, a determined wager, in the form of an unsavory cooperation, may create possible way outs.

Resumen Ante las altas tasas de mortalidad y encarcelamiento de jóvenes negros brasileños, pobres y residentes en la periferia, se presenta una investigación transdisciplinaria que busca calificar los eventos, transiciones y rupturas que marcan sus trayectorias, analizando el ciclo de vida, desvelando sus vínculos, movimientos y factores de riesgo. Para ello, se partió de la encuesta de Planos Individuais de Atendimento (“Planes de Atención Individualizados”) de adolescentes en cumplimiento de medida socioeducativa para luego realizar una búsqueda activa de estos temas con el fin de aplicarles un cuestionario e invitarlos a contar sus historias de vida utilizando la metodología de Narrativas Memorialistas. A partir del análisis de caso, que revela el potencial universal de cada vida singular, se analizaron cuatro ejes identificados a partir del propio discurso del joven: la violencia del Estado, la adolescencia, la mortalidad y la apuesta. En contraste con la precariedad y la falta de apoyo a la que se arrojan algunas vidas, desvelando la muerte, una apuesta decidida, traducida en el ofrecimiento de algún vínculo, parece llamar a la construcción de posibles salidas.

https://doi.org/10.1590/1982-3703003231908

SARS-CoV-2 and rhinovirus infections: are there differences in clinical presentation, laboratory abnormalities, and outcomes in the pediatric population?
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Pereira, Maria Fernanda Bádue

; Suguita, Priscila

; Litvinov, Nadia

; Farhat, Sylvia Costa Lima

; Paula, Camila Sanson Yoshino de

; Lázari, Carolina dos Santos

; Bedê, Pedro Vale

; Framil, Juliana Valeria de Souza

; Bueno, Catarina

; Branas, Priscila Cristina Abduch Adas

; Guimarães, Irina Monteiro da Costa

; Leite, Marcia Marques

; Navega, Ana Carolina Barsaglini

; Nanbu, Danilo Yamamoto

; Schvartsman, Claudio

; Pinho, João Renato Rebello

; Silva, Clovis Artur Almeida

; Marques, Heloisa Helena de Sousa

; Eisencraft, Adriana Pasmanik

; Rossi Jr, Alfio

; Delgado, Artur Figueiredo

; Leal, Gabriela Nunes

; Gibelli, Maria Augusta Cicaroni

; Palmeira, Patricia

; Sakita, Neusa Keico

; Santos, Emilly Henrique dos

; Rocha, Mussya Cisotto

; Kanunfre, Kelly Aparecida

; Okay, Thelma Suely

; Carneiro-Sampaio, Magda

; Carvalho, Werther Brunow de

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e34

Resumo: En | Texto: En | PDF: En

ABSTRACT This study aims to assess COVID-19 and other respiratory viruses in pediatric patients. Between April 17 and September 30, 2020, we collected 1,566 respiratory samples from 1,044 symptomatic patients who were younger than 18 years old to assess SARS-CoV-2 infection. Of these, 919 were analyzed for other respiratory pathogens (ORP). Patients with laboratory-confirmed COVID-19 or ORP were included. We evaluated 76 pediatric COVID-19 infections and 157 other respiratory virus infections. Rhinovirus occurred in 132/157 (84%). COVID-19 patients who were significantly older, had more fevers, headaches and pneumonia than those with ORP. The median white blood cell count was lower in patients with SARS-CoV-2 than in those with ORP (6,470 versus 8,170; p=0.02). COVID-19 patients had significantly worse symptoms than those with ORP.

https://doi.org/10.1590/s1678-9946202264034

Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital
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Marques, Heloisa Helena de Sousa

; Pereira, Maria Fernanda Badue

; Santos, Angélica Carreira dos

; Fink, Thais Toledo

; Paula, Camila Sanson Yoshino de

; Litvinov, Nadia

; Schvartsman, Claudio

; Delgado, Artur Figueiredo

; Gibelli, Maria Augusta Bento Cicaroni

; Carvalho, Werther Brunow de

; Odone Filho, Vicente

; Tannuri, Uenis

; Carneiro-Sampaio, Magda

; Grisi, Sandra

; Duarte, Alberto José da Silva

; Antonangelo, Leila

; Francisco, Rossana Pucineli Vieira

; Okay, Thelma Suely

; Batisttella, Linamara Rizzo

; Carvalho, Carlos Roberto Ribeiro de

; Brentani, Alexandra Valéria Maria

; Silva, Clovis Artur

; Eisencraft, Adriana Pasmanik

; Rossi Junior, Alfio

; Fante, Alice Lima

; Cora, Aline Pivetta

; Reis, Amelia Gorete A. de Costa

; Ferrer, Ana Paula Scoleze

; Andrade, Anarella Penha Meirelles de

; Watanabe, Andreia

; Gonçalves, Angelina Maria Freire

; Waetge, Aurora Rosaria Pagliara

; Silva, Camila Altenfelder

; Ceneviva, Carina

; Lazari, Carolina dos Santos

; Abellan, Deipara Monteiro

; Santos, Emilly Henrique dos

; Sabino, Ester Cerdeira

; Bianchini, Fabíola Roberta Marim

; Alcantara, Flávio Ferraz de Paes

; Ramos, Gabriel Frizzo

; Leal, Gabriela Nunes

; Rodriguez, Isadora Souza

; Pinho, João Renato Rebello

; Carneiro, Jorge David Avaizoglou

; Paz, Jose Albino

; Ferreira, Juliana Carvalho

; Ferranti, Juliana Ferreira

; Ferreira, Juliana de Oliveira Achili

; Framil, Juliana Valéria de Souza

; Silva, Katia Regina da

; Kanunfre, Kelly Aparecida

; Bastos, Karina Lucio de Medeiros

; Galleti, Karine Vusberg

; Cristofani, Lilian Maria

; Suzuki, Lisa

; Campos, Lucia Maria Arruda

; Perondi, Maria Beatriz de Moliterno

; Diniz, Maria de Fatima Rodrigues

; Fonseca, Maria Fernanda Mota

; Cordon, Mariana Nutti de Almeida

; Pissolato, Mariana

; Peres, Marina Silva

; Garanito, Marlene Pereira

; Imamura, Marta

; Dorna, Mayra de Barros

; Luglio, Michele

; Rocha, Mussya Cisotto

; Aikawa, Nadia Emi

; Degaspare, Natalia Viu

; Sakita, Neusa Keico

; Udsen, Nicole Lee

; Scudeller, Paula Gobi

; Gaiolla, Paula Vieira de Vincenzi

; Severini, Rafael da Silva Giannasi

; Rodrigues, Regina Maria

; Toma, Ricardo Katsuya

; Paula, Ricardo Iunis Citrangulo de

; Palmeira, Patricia

; Forsait, Silvana

; Farhat, Sylvia Costa Lima

; Sakano, Tânia Miyuki Shimoda

; Koch, Vera Hermina Kalika

; Cobello Junior, Vilson

Clinics

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2021, Volume 76 elocation e3488

Resumo: En | Texto: En | PDF: En

OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results. RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). Likewise, the frequencies of enoxaparin use (p=0.037), current immunosuppressant use (p=0.008), vasoactive agents (p=0.045), arterial hypotension (p<0.001), and shock (p=0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p=0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p=0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p=0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p=0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p=0.007) and multisystem inflammatory syndrome in children (MIS-C) (OR 11.261; 95% CI 1.189-106. 581; p=0.035). CONCLUSIONS: Half of the laboratory-confirmed COVID-19 cases occurred in adolescents. Individuals belonging to this age group had an acute systemic involvement of SARS-CoV-2 infection. Pediatric SARS and MIS-C were the most important factors associated with the mortality rate in pediatric chronic conditions with COVID-19.

https://doi.org/10.6061/clinics/2021/e3488

Safety of local anesthetics,
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Cherobin, Ana Carolina Figueiredo Pereira

; Tavares, Glaysson Tassara

Anais Brasileiros de Dermatologia

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Fev 2020, Volume 95 Nº 1 Páginas 82 - 90

Resumo: En | Texto: En | PDF: En

Abstract Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types. Systemic toxicity with reflex on the central nervous and cardiovascular systems is their most feared adverse reactions, and the anaphylactic reaction is the most concerning one. Although potentially fatal, these events are extremely rare, so local anesthetics are considered safe for use in in-office procedures.

https://doi.org/10.1016/j.abd.2019.09.025 1803 downloads

Dengue diagnostics: serious inaccuracies are likely to occur if pre-analytical conditions are not strictly followed
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Iani, Felipe Campos de Melo

; Caetano, Ana Carolina Barbosa

; Cocovich, Jéssica Caroline Wenceslau

; Amâncio, Frederico Figueiredo

; Pereira, Maira Alves

; Adelino, Talita Émile Ribeiro

; Caldas, Sérgio

; Silva, Marcos Vinícius Ferreira

; Pereira, Glauco de Carvalho

; Duarte, Myrian Morato

Memórias do Instituto Oswaldo Cruz

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2020, Volume 115 elocation e200287

Resumo: En | Texto: En | PDF: En

BACKGROUND The heat-labile nature of Dengue virus (DENV) in serum samples must be considered when applying routine diagnostic tests to avoid issues that could impact the accuracy of test results with direct implications for case management and disease reporting. OBJECTIVES To check if pre-analytical variables, such as storage time and temperature, have an impact on the accuracy of the main routine diagnostic tests for dengue. METHODS Virus isolation, reverse transcription real-time polymerase chain reaction (RT-PCR) and NS1 enzyme-linked immunosorbent assay (ELISA) were evaluated using 84 samples submitted to different pre-analytical conditions. FINDINGS Sensitivity and negative predictive value were directly affected by sample storage conditions. RT-PCR and virus isolation showed greater dependence on well-conserved samples for an accurate diagnosis. Interestingly, even storage at -30ºC for a relatively short time (15 days) was not adequate for accurate results using virus isolation and RT-PCR tests. On the other hand, NS1 ELISA showed no significant reduction in positivity for aliquots tested under the same conditions as in the previous tests. MAIN CONCLUSIONS Our results support the stability of the NS1 marker in ELISA diagnosis and indicate that the accuracy of routine tests such as virus isolation and RT-PCR is significantly affected by inadequate transport and storage conditions of serum samples.

https://doi.org/10.1590/0074-02760200287 354 downloads

Demographic profile of patients and clinical characteristics of dental emergencies at the outpatient clinic of a Brazilian Dental School
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PEREIRA, Andrea Cardoso

; CERQUEIRA NETO, Ana Carolina Correia Laurindo de

; ZAIA, Alexandre Augusto

; GOMES, Brenda Paula Figueiredo de Almeida

; ALMEIDA, José Flávio Affonso de

; SOARES, Adriana de Jesus

RGO - Revista Gaúcha de Odontologia

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Dez 2018, Volume 66 Nº 4 Páginas 345 - 351

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Este estudo retrospectivo avaliou o perfil demográfico dos pacientes e as características clínicas das urgências dentárias em um Serviço de Plantão de Urgências de uma Faculdade brasileira de Odontologia. Métodos: Durante o período de junho de 2013 a maio de 2014, os dados foram coletados de 1.345 registros clínicos, com informações sobre a queixa principal, gênero, idade, alteração sistêmica, inspeção clínica do dente afetado, diagnóstico pulpar e periapical, o tipo de procedimento realizado e se houve necessidade de medicação sistêmica pós-operatória. Os dados foram analisados usando o software SAS e o teste do qui-quadrado foi utilizado para verificar a presença ou ausência de significância estatística ao nível de 5%. Resultados: A dor dental (53,3%) foi a queixa principal mais encontrada. Pacientes do gênero feminino (63,1%), com idade entre 29-48 anos (42%), sem condições sistêmicas (75%) e com dentes cariados (25%) foram os mais prevalentes. Além disso, o envolvimento de molares inferiores (29,81%) e o diagnóstico de pulpite irreversível (30,42%) foram os achados mais frequentes. O tratamento endodôntico de urgência (45,8%) foi o procedimento mais realizado. A pulpite irreversível (30,4%) e a necrose pulpar associada a periodontite apical aguda (21,9%) foram as condições mais frequentes que necessitaram de tratamento endodôntico de urgência e, na maioria dos casos, não houve prescrição de medicamentos sistêmicos pós-operatórios (95,7%). Conclusão: A prevalência de urgências endodônticas durante o período de um ano enfatiza a necessidade de diagnósticos mais precisos e a importância de oferecer esse serviço à população.

ABSTRACT Objective: This retrospective study evaluated the demographic profile of patients and the clinical characteristics of dental emergencies in a brazilian university outpatient clinic. Methods: During the period from June 2013 to May 2014, data were collected from 1.345 clinical records. Chief complaint, gender, age, systemic alteration, clinical inspection of the affected tooth, pulp and periapical diagnosis, the type of procedure performed and whether there was the need for post-operative systemic medication. Data were analyzed using the SAS software and chi-square test was used to verify the presence or absence of statistical significance at a level of 5%. Results: Dental pain (53.3%) was the main reason why people attended the emergency service, that is, female patients (63.1%), aged 29-48 years old (42%), patients without systemic conditions (75%), and patients with decayed teeth (25%). In addition, involvement of lower molars (29.81%) and diagnosis of irreversible pulpitis (30.42%) were the most frequent findings. Emergency endodontic treatment (45.8%) was the most performed procedure. Irreversible pulpitis (30.4%) and pulp necrosis associated with acute apical periodontitis (21.9%) were the most frequent conditions requiring emergency endodontic treatment, and in most cases, there was no need for post-operative systemic medications (95.7%). Conclusion: The prevalence of endodontic emergencies during the period of one year emphasizes the need for more accurate diagnosis and the importance of providing this service to the population.

https://doi.org/10.1590/1981-863720180004000083530 961 downloads

Prognostic factors for metastasis in cutaneous melanoma
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Cherobin, Ana Carolina Figueiredo Pereira

; Wainstein, Alberto Julius Alves

; Colosimo, Enrico Antônio

; Goulart, Eugênio Marcos Andrade

; Bittencourt, Flávia Vasques

Anais Brasileiros de Dermatologia

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Fev 2018, Volume 93 Nº 1 Páginas 19 - 26

Resumo: En | Texto: En | PDF: En

Abstract: Background: Melanoma is a malignant neoplasia that shows high mortality when diagnosed in advanced stages. Early identification of high-risk patients for the development of melanoma metastases is the main strategy to reduce mortality. Objective: To assess the influence of eight epidemiological and histopathologic features on the development of metastases in patients diagnosed with primary cutaneous melanoma. Methods: Our historical cohort comprised patients with invasive primary cutaneous melanoma seen between 1995 and 2012 at a public university hospital and a private oncologic surgery institution in Southeastern Brazil. The following variables were analyzed: gender, age, family history of melanoma, site of the primary tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and the mitotic index. Kaplan-Meier univariate test and multivariate Cox proportional hazard analysis were used to assess factors associated with disease-free survival. Results: Five hundred and fourteen patients were enrolled. The univariate analysis identified the following significant risk factors: gender, age, site of the tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and mitotic index. Multivariate analysis included 244 patients and detected four significant prognostic factors: male gender, nodular clinical and histologic subtype, Breslow thickness > 4mm, and histologic ulceration. The mitotic index was not included in this analysis. Study limitations: Small number of patients in multivariate analysis. Conclusions: The following prognostic factors to the development of melanoma metastasis were identified in the study: male gender, nodular histologic subtype, Breslow thickness > 4mm and ulceration.

https://doi.org/10.1590/abd1806-4841.20184779 2383 downloads

Case for diagnosis
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Cherobin, Ana Carolina Figueiredo Pereira

; Oliveira, Felipe Osta de

; Baeta, Isabela Guimarães Ribeiro

; Vale, Everton Carlos Siviero do

Anais Brasileiros de Dermatologia

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Fev 2012, Volume 87 Nº 1 Páginas 151 - 152

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Erythema dyschromicum perstans ou dermatose cinzenta é enfermidade cutânea adquirida, rara, de evolução crônica, caracterizada por máculas acinzentadas, com bordas eritematosas. A etiologia ainda é desconhecida, não havendo tratamento definido para a afecção. Apresenta-se um caso desta dermatose em paciente de 41 anos, com lesões disseminadas no tronco e membros.

Dyschromicum erythema perstans, or ashy dermatosis, is a rare chronic acquired skin disease characterized by gray hyperpigmented patches with erythematous borders. Its etiology is unknown and there is no specific treatment for the condition. We report a case of ashy dermatosis in a 41-year-old patient with extensive lesions on the trunk and limbs.

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Baeta, Isabela Guimarães Ribeiro

; Pereira, Ana Carolina Figueiredo

; Guedes, Antônio Carlos Martins

; Pereira, Luciana Baptista

Anais Brasileiros de Dermatologia

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Jun 2011, Volume 86 Nº 3 Páginas 605 - 607

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

A síndrome KLICK é uma genodermatose rara, autossômica recessiva, caracterizada pela associação de queratodermia palmo-plantar difusa e transgressiva, com esclerodactilia, placas hiperqueratóticas lineares localizadas preferencialmente em flexuras e ictiose congênita. Não há alterações em fâneros ou mucosas, assim como sintomas sistêmicos associados. O tratamento consiste no uso de queratolíticos tópicos e retinóides orais

Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK) syndrome is a rare autosomal recessive skin disorder characterized by the association of diffuse, transgressive palmoplantar keratoderma with sclerodactyly, linear hyperkeratotic plaques generally located in flexures, and congenital ichthyosis. The patient is physically and mentally healthy and has no history of any problems related to teeth, nails, hair or mucous membranes. Treatment is based on the use of topical keratolytics and oral retinoids

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11.

Elastose perfurante serpiginosa em portadora da síndrome de Down
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Pereira, Ana Carolina Figueiredo

; Baeta, Isabela Guimarães Ribeiro

; Costa Júnior, Sérgio Rodrigues da

; Gontijo Júnior, Oswaldo Macedo

; Vale, Everton Carlos Siviero do

Anais Brasileiros de Dermatologia

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Out 2010, Volume 85 Nº 5 Páginas 691 - 694

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

A elastose perfurante serpiginosa é dermatose perfurante primária incomum, frequentemente associada a determinadas doenças genéticas e caracterizada por eliminação transepidérmica de fibras elásticas. Relata-se um caso raro dessa dermatose em paciente feminina de 19 anos, portadora da síndrome de Down, que apresentava pápulas eritematoceratóticas em arranjo arciforme, localizadas no antebraço e joelho direitos, assintomáticas, com cinco anos de evolução. Após confirmação histopatológica, foi iniciado tratamento com crioterapia, ocorrendo remissão parcial das lesões.

Elastosis perforans serpiginosa is a rare, primary perforating dermatosis, frequently associated with certain genetic diseases and characterized by the transepidermal extrusion of elastic fibers. The present case report describes this dermatosis in a 19-year old female patient with Down's syndrome, who presented with asymptomatic erythematous, keratotic papules in an arciform pattern, located on her right forearm and knee, which had been present for five years. Following histopathological confirmation, treatment with cryotherapy was initiated, resulting in partial remission of the lesions.

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12.

Síndrome do nevo de Becker: relato de caso
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Baeta, Isabela Guimarães Ribeiro

; Viotti, Carla Vilela

; Pereira, Ana Carolina Figueiredo

; Costa Júnior, Sérgio Rodrigues da

; Bittencourt, Flávia Vasques

Anais Brasileiros de Dermatologia

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Out 2010, Volume 85 Nº 5 Páginas 713 - 716

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

O nevo de Becker se manifesta como uma mácula hipercrômica, localizada predominantemente no tronco anterior ou região escapular, e frequentemente associada à hipertricose. A coexistência do nevo de Becker e anormalidades cutâneas, músculo-esqueléticas ou maxilo-faciais corresponde à síndrome do nevo de Becker. Relata-se o caso de uma paciente de 16 anos, portadora desde os sete anos de mácula hipercrômica, localizada no tronco ântero-lateral direito, estendendo-se até a face medial da coxa direita, acompanhada de hipoplasia mamária ipsilateral. O exame anatomopatológico confirmou a hipótese clínica de nevo de Becker.

Becker's nevus is a hyperpigmented macula that is predominantly located on the anterior trunk or on the scapular region, frequently associated with hypertrichosis. The association of Becker's nevus with other cutaneous, musculoskeletal or maxillofacial anomalies has been called Becker's nevus syndrome. We report a case of a 16-year-old girl with a hyperpigmented macula which spread from her right anterolateral trunk to the inner part of her right thigh accompanied by ipsilateral mammary hypoplasia. The skin lesion started when the patient was seven years old when it was also noticed ipsilateral mammary hypoplasia. The histological exam confirmed the clinical hypothesis of Becker's nevus.

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13.

Clinical versus ultrasound examination in the evaluation of hepatosplenic schistosomiasis mansoni in endemic areas
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Marinho, Carolina Coimbra

; Voieta, Izabela

; Azeredo, Letícia Martins

; Nishi, Marina Pires

; Batista, Thaís Sanai

; Pereira, Ana Carolina Figueiredo

; Serufo, José Carlos

; Queiroz, Leonardo Campos de

; Ruiz-Guevara, Raiza

; Antunes, Carlos Maurício

; Prata, Aluízio

; Lambertucci, José Roberto

Memórias do Instituto Oswaldo Cruz

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Out 2006, Volume 101 Supl. 1 Páginas 317 - 321

Resumo: En | Texto: En | PDF: En

The best way to appraise the size of abdominal organs remains undefined. Herein we compare the size of liver and spleen in hepatosplenic schistosomiasis using clinical and ultrasound (US) examination, and the size of the organs measured by US with their visualization below the costal margin ("palpable by US"). For this study, 411 individuals from an endemic area for schistosomiasis mansoni in Brazil have been selected. We found that palpable spleens and left liver lobes are larger than non palpable ones. Also, 23% of normal spleens measured by US were palpable on clinical examination, and 22% of spleens increased in size on US were non palpable. A total of 21% of normal spleens were "palpable by US". We also found 54% of normal sized right liver lobes palpable on clinical examination, whilst 54% of the increased livers, measured by US, were non palpable. About 76% of normal right liver lobes were "palpable by US". We conclude that the association of clinical, ultrasound and magnetic resonance imaging (MRI) examinations, in the near future, should give the investigators the necessary tools to perform a more accurate clinical diagnosis of hepatosplenic schistosomiasis mansoni.

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