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ABSTRACT This is a cost analysis study based on hospital admissions, conducted from the perspective of the Brazilian Unified Health System (SUS), carried out in a cohort of patients hospitalized at the University Hospital of Brasília (UHB) due to Severe Acute Respiratory Infections (SARI) caused by COVID-19, from April 1, 2020, to March 31, 2022. An approach based on macro-costingwas used,considering thecosts perpatient identified in the Hospital Admission Authorizations (HAA). Were identified 1,015 HAA from 622 patients. The total cost of hospitalizations was R$ 2,875,867.18 for 2020 and 2021. Of this total, 86.41 % referred to hospital services and 13.59 % to professional services. The highest median cost per patient identified was for May 2020 (R$ 19,677.81 IQR [3,334.81–33,041.43]), while the lowest was in January 2021 (R$ 1,698.50 IQR [1,602.70–2,224.11]). The high cost of treating patients with COVID-19 resulted in a high economic burden of SARI due to COVID-19 for UHB and, consequently, for SUS. admissions SUS, SUS , (SUS) (UHB (SARI COVID19, COVID19 COVID 19, 19 1 31 2022 macrocostingwas macro costingwas usedconsidering used considering HAA. . (HAA) 1015 015 1,01 62 R 287586718 2 875 867 18 2,875,867.1 202 8641 86 41 86.4 1359 13 59 13.5 (R 1967781 677 81 19,677.8 3,334.81–33,041.43, 3334813304143 3,334.81–33,041.43 3 334 33 041 43 [3,334.81–33,041.43]) 169850 698 50 1,698.5 1,602.70–2,224.11. 160270222411 1,602.70–2,224.11 602 70 224 11 [1,602.70–2,224.11]) COVID-1 consequently (SUS COVID1 (HAA 101 01 1,0 6 28758671 87 2,875,867. 20 864 8 4 86. 135 5 13. 196778 67 19,677. 333481330414 3,334.81–33,041.4 04 [3,334.81–33,041.43] 16985 69 1,698. 16027022241 1,602.70–2,224.1 60 7 22 [1,602.70–2,224.11] COVID- 10 0 2875867 2,875,867 19677 19,677 33348133041 3,334.81–33,041. [3,334.81–33,041.43 1698 1,698 1602702224 1,602.70–2,224. [1,602.70–2,224.11 287586 2,875,86 1967 19,67 3334813304 3,334.81–33,041 [3,334.81–33,041.4 169 1,69 160270222 1,602.70–2,224 [1,602.70–2,224.1 28758 2,875,8 196 19,6 333481330 3,334.81–33,04 [3,334.81–33,041. 16 1,6 16027022 1,602.70–2,22 [1,602.70–2,224. 2875 2,875, 33348133 3,334.81–33,0 [3,334.81–33,041 1602702 1,602.70–2,2 [1,602.70–2,224 287 2,875 3334813 3,334.81–33, [3,334.81–33,04 160270 1,602.70–2, [1,602.70–2,22 28 2,87 333481 3,334.81–33 [3,334.81–33,0 16027 1,602.70–2 [1,602.70–2,2 2,8 33348 3,334.81–3 [3,334.81–33, 1602 1,602.70– [1,602.70–2, 2, 3334 3,334.81– [3,334.81–33 160 1,602.70 [1,602.70–2 333 3,334.81 [3,334.81–3 1,602.7 [1,602.70– 3,334.8 [3,334.81– 1,602. [1,602.70 3,334. [3,334.81 1,602 [1,602.7 3,334 [3,334.8 1,60 [1,602. 3,33 [3,334. [1,602 3,3 [3,334 [1,60 3, [3,33 [1,6 [3,3 [1, [3, [1 [3 [