Abstract BACKGROUND: Chronically elevated alpha-2-macroglobulin (A2MG) in the blood has been correlated with diabetes and the HbA1c profile; however, no systematic review has been conducted to evaluate the association of A2MG salivary levels and glycemia or HbA1c levels in diabetes mellitus type 2 (DM2) patients. OBJECTIVE: To evaluate whether A2MG salivary levels are related to the glycemia or HbA1c levels in DM2 patients. DESIGN AND SETTING: Systematic review developed at Universidade Federal de Uberlândia (UFU), Brazil. METHODS: Eight databases were used as research sources. The eligibility criteria included studies that reported data regarding mean salivary A2MG and the correlation between glycemia and/or HbA1c levels of DM2 subjects (uncontrolled and well-controlled) and non-diabetic subjects. The risk of bias of the studies selected was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools for use in JBI systematic reviews. Pooled correlation coefficients were estimated using the Hunter-Schmidt method. Study estimates were weighted according to their sample size, and heterogeneity was calculated using the chi-square statistic. RESULTS: Four studies on DM2 patients were included in this systematic review after careful analysis of 1482 studies. Three studies compared A2MG with HbA1c and glycemia. Overall, the correlation between A2MG and HbA1c was strong (r = 0.838). In contrast, the correlation between A2MG and glycemia was low (r = 0.354). CONCLUSION: The strong association between HbA1C and salivary A2MG suggests that this salivary protein has the potential to be a surrogate for HbA1C, if corroboratory further evidence is obtained through large-scale studies.

Abstract BACKGROUND: Chronically elevated alpha-2-macroglobulin (A2MG) in the blood has been correlated with diabetes and the HbA1c profile; however, no systematic review has been conducted to evaluate the association of A2MG salivary levels and glycemia or HbA1c levels in diabetes mellitus type 2 (DM2) patients. OBJECTIVE: To evaluate whether A2MG salivary levels are related to the glycemia or HbA1c levels in DM2 patients. DESIGN AND SETTING: Systematic review developed at Universidade Federal de Uberlândia (UFU), Brazil. METHODS: Eight databases were used as research sources. The eligibility criteria included studies that reported data regarding mean salivary A2MG and the correlation between glycemia and/or HbA1c levels of DM2 subjects (uncontrolled and well-controlled) and non-diabetic subjects. The risk of bias of the studies selected was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools for use in JBI systematic reviews. Pooled correlation coefficients were estimated using the Hunter-Schmidt method. Study estimates were weighted according to their sample size, and heterogeneity was calculated using the chi-square statistic. RESULTS: Four studies on DM2 patients were included in this systematic review after careful analysis of 1482 studies. Three studies compared A2MG with HbA1c and glycemia. Overall, the correlation between A2MG and HbA1c was strong (r = 0.838). In contrast, the correlation between A2MG and glycemia was low (r = 0.354). CONCLUSION: The strong association between HbA1C and salivary A2MG suggests that this salivary protein has the potential to be a surrogate for HbA1C, if corroboratory further evidence is obtained through large-scale studies.

RESUMO Objetivos: desenvolver uma revisão sistemática e metanálise de estudos qualitativos sobre a qualidade de vida relacionada ao trabalho de profissionais da Saúde da Família. Métodos: a revisão sistemática foi desenvolvida para responder à seguinte questão pautada no método PVO: “Quais fatores (variáveis) estão associados com a qualidade de vida relacionada ao trabalho (resultado) de profissionais da Estratégia Saúde da Família (população)?” As bases de dados PubMed, Scopus, Embase, SciELO, Web of Science, LILACS, Science Direct, OpenThesis, OpenGrey e OATD foram selecionadas. A metassíntese analisou as categorias principais e subcategorias de todos os estudos incluídos. Resultados: a busca na base de dados resultou em 1.744 registros, e seis deles foram considerados elegíveis para a metassíntese. Quatro fatores foram considerados para a qualidade de vida relacionada ao trabalho: condições de trabalho, processo de trabalho, relações interpessoais e aspectos pessoais. Conclus ões : embora este estudo confirme a adequação de aspectos comumente relacionados à qualidade de vida no trabalho, outros fatores são importantes no caso dos profissionais da Saúde da Família, especialmente o contexto de trabalho.

ABSTRACT Objectives: to perform a systematic review and meta-synthesis of qualitative studies about the work-related quality of life of Family Health Strategy professionals. Methods: this systematic review was developed to answer the following PVO question: “Which factors (variables) are associated with the work-related quality of life (outcome) of Family Health Strategy professionals (population)?” The PubMed, Scopus, Embase, SciELO, Web of Science, LILACS, Science Direct, OpenThesis, OpenGrey, and OATD databases were selected. The meta-synthesis analyzed the main codes and secondary codes of all included studies. Results: the database search resulted in 1,744 reports; six were considered eligible for the meta-synthesis. Four factors were considered for the quality of work life: working conditions; work processes; interpersonal relationships; and personal aspects. Conclusions: although this study confirms the adequacy of aspects commonly related to the quality of work life, other factors are important in the case of FHS professionals, especially work context.

RESUMEN Objetivos: desarrollar una revisión sistemática y metaanálisis de estudios cualitativos sobre la calidad de vida relacionada al trabajo de profesionales de Salud de la Familia. Métodos: la revisión sistemática se desarrolló para responder la siguiente pregunta pautada en metodología PVO: “¿Cuáles factores (variables) están asociados con la calidad de vida relacionada al trabajo (resultado) de profesionales de Estrategia Salud de la Familia (población)?”. Fueron seleccionadas las bases PubMed, Scopus, Embase, SciELO, Web of Science, LILACS, Science Direct, OpenThesis, OpenGrey y OATD. La metasíntesis analizó las categorías principales y subcategorías de todos los estudios incluidos. Resultados: la búsqueda en bases halló 1.744 registros, seis de ellos fueron considerados elegibles para la calidad de vida relacionada al trabajo: condiciones laborales, proceso de trabajo, relaciones interpersonales y aspectos personales. Conclusiones: Aunque este estudio confirme que algunos aspectos habitualmente relacionados con la calidad de vida son adecuados, hay otros factores importantes para los profesionales de Salud de la Familia, particularmente el ámbito laboral.

ABSTRACT Objectives: to perform a systematic review and meta-synthesis of qualitative studies about the work-related quality of life of Family Health Strategy professionals. Methods: this systematic review was developed to answer the following PVO question: “Which factors (variables) are associated with the work-related quality of life (outcome) of Family Health Strategy professionals (population)?” The PubMed, Scopus, Embase, SciELO, Web of Science, LILACS, Science Direct, OpenThesis, OpenGrey, and OATD databases were selected. The meta-synthesis analyzed the main codes and secondary codes of all included studies. Results: the database search resulted in 1,744 reports; six were considered eligible for the meta-synthesis. Four factors were considered for the quality of work life: working conditions; work processes; interpersonal relationships; and personal aspects. Conclusions: although this study confirms the adequacy of aspects commonly related to the quality of work life, other factors are important in the case of FHS professionals, especially work context.

RESUMEN Objetivos: desarrollar una revisión sistemática y metaanálisis de estudios cualitativos sobre la calidad de vida relacionada al trabajo de profesionales de Salud de la Familia. Métodos: la revisión sistemática se desarrolló para responder la siguiente pregunta pautada en metodología PVO: “¿Cuáles factores (variables) están asociados con la calidad de vida relacionada al trabajo (resultado) de profesionales de Estrategia Salud de la Familia (población)?”. Fueron seleccionadas las bases PubMed, Scopus, Embase, SciELO, Web of Science, LILACS, Science Direct, OpenThesis, OpenGrey y OATD. La metasíntesis analizó las categorías principales y subcategorías de todos los estudios incluidos. Resultados: la búsqueda en bases halló 1.744 registros, seis de ellos fueron considerados elegibles para la calidad de vida relacionada al trabajo: condiciones laborales, proceso de trabajo, relaciones interpersonales y aspectos personales. Conclusiones: Aunque este estudio confirme que algunos aspectos habitualmente relacionados con la calidad de vida son adecuados, hay otros factores importantes para los profesionales de Salud de la Familia, particularmente el ámbito laboral.

RESUMO Objetivos: desenvolver uma revisão sistemática e metanálise de estudos qualitativos sobre a qualidade de vida relacionada ao trabalho de profissionais da Saúde da Família. Métodos: a revisão sistemática foi desenvolvida para responder à seguinte questão pautada no método PVO: “Quais fatores (variáveis) estão associados com a qualidade de vida relacionada ao trabalho (resultado) de profissionais da Estratégia Saúde da Família (população)?” As bases de dados PubMed, Scopus, Embase, SciELO, Web of Science, LILACS, Science Direct, OpenThesis, OpenGrey e OATD foram selecionadas. A metassíntese analisou as categorias principais e subcategorias de todos os estudos incluídos. Resultados: a busca na base de dados resultou em 1.744 registros, e seis deles foram considerados elegíveis para a metassíntese. Quatro fatores foram considerados para a qualidade de vida relacionada ao trabalho: condições de trabalho, processo de trabalho, relações interpessoais e aspectos pessoais. Conclus ões : embora este estudo confirme a adequação de aspectos comumente relacionados à qualidade de vida no trabalho, outros fatores são importantes no caso dos profissionais da Saúde da Família, especialmente o contexto de trabalho.