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Optimization of the Electrical Properties of PVDF Nanofibers with the Addition of P3HT and PCBM Processed by Electrospinning PHT P HT
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Silva, Pedro Leonardo

; Gois, Bruno Henrique de Santana

; Silva, André Antunes da Santos, Vagner dos Mingroni, Vitor Hugo Uzeloto Fernandes Paschoal, Giovana Aibara Miti Gois, Patrik Diones de Santana Carvalho Júnior, Valdemiro Pereira de Olivati, Clarissa de Almeida Hiorns, Roger Clive Agostini, Deuber Lincon da Silva

Materials Research

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2024, Volume 27 Supl. 2 elocation e20240198

Resumo: En | Texto: En | PDF: En

In this study, electrospun nanofibers of poly(vinylidene fluoride) (PVDF) were produced with the addition of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) and poly(3-hexylthiophene) (P3HT), for application as a nanostructured active layer of bulk heterojunction polymer with fullerene and polythiophene derivatives in third-generation photovoltaic devices. The electrospinning technique was used to favor the formation of the β phase, exhibiting ferroelectric properties, improving the electrical performance of the device. The morphological, structural and electrical characteristics of the nanofibers were investigated using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and DC electrical measurements. The synergism between nanofiber processing and the addition of P3HT and PCBM improved electrical conductivity by up to three orders of magnitude, furthermore, the nanofibers incorporating P3HT exhibited responses to solar stimuli. study polyvinylidene poly vinylidene fluoride PVDF (PVDF 6,6phenylC61butyric 66phenylC61butyric phenylCbutyric 6,6 phenyl C61 butyric 6 C (PCBM poly3hexylthiophene polyhexylthiophene 3 hexylthiophene poly(3-hexylthiophene P3HT, PHT , P HT (P3HT) thirdgeneration third generation devices phase properties device morphological SEM, SEM (SEM) FTIR (FTIR measurements magnitude furthermore stimuli 6phenylC61butyric phenylC 66 6, C6 (P3HT (SEM

https://doi.org/10.1590/1980-5373-mr-2024-0198

Thyroid hormone profile is related to prognosis in acute decompensation of cirrhosis
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Nardin, Giovana De

; Colombo, Bruno da Silveira

; Ronsoni, Marcelo Fernando

; Silva, Pedro Eduardo Soares e

; Fayad, Leonardo

; Wildner, Letícia Muraro

; Bazzo, Maria Luiza

; Dantas-Correa, Esther Buzaglo

; Narciso-Schiavon, Janaína Luz

; Schiavon, Leonardo de Lucca

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230249

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective To investigate the prognostic significance of thyroid hormone profile in patients hospitalized for decompensated cirrhosis. Subjects and methods Prospective cohort study that included 119 subjects. All subjects were evaluated at admission and followed for 90 days. TSH, fT3, fT4 were measured within 24 hours of hospitalization. Results Higher fT4 and lower fT3 levels were observed among Child-Pugh C patients as compared to Child-Pugh A and B, and in those with acute-on-chronic liver failure (ACLF). Lower fT3/fT4 ratio was observed in those with ascites, infections, ACLF, and in Child-Pugh C. Ninety-day mortality was 26.9% and it was independently associated with higher Model for End-stage Liver Disease (MELD) and TSH, and lower fT3/fT4 ratio in multivariate analysis. A new prognostic model including MELD, TSH and fT3/fT4 ratio was devised. The areas under the receiver operating characteristic curves for MELD, fT3/fT4 ratio, TSH (μIU/mL), and the new model for predicting 90-day mortality were 0.847 ± 0.041, 0.841 ± 0.039, 0.658 ± 0.062, and 0.899 ± 0.031, respectively. The 90-day survival was 31.6% in patients with values of the predictive model ≥ -0.77 and 93.5% for values < -0.77 (P < 0.001). Conclusions Thyroid hormone profile was strongly associated with worse outcomes in patients with cirrhosis and might represent promising prognostic tools that can be incorporated in clinical practice. 11 9 days fT 2 hospitalization ChildPugh Child Pugh B acuteonchronic acute on chronic ACLF. ACLF . (ACLF) fT3fT4 fTfT fT3/fT ascites infections Ninetyday Ninety day 269 26 26.9 Endstage End stage MELD (MELD analysis devised μIU/mL, μIUmL μIU/mL , μIU mL (μIU/mL) 90day 0847 0 847 0.84 0041 041 0.041 0841 841 0039 039 0.039 0658 658 0.65 0062 062 0.062 0899 899 0.89 0031 031 0.031 respectively 316 31 6 31.6 0.77 077 77 -0.7 935 93 5 93.5 P 0.001. 0001 0.001 001 0.001) practice 1 (ACLF fT3fT 26. (μIU/mL 084 84 0.8 004 04 0.04 003 03 0.03 065 65 0.6 006 06 0.06 089 89 3 31. 0.7 07 7 -0. 93. 000 0.00 00 08 8 0. 0.0 -0 -

https://doi.org/10.20945/2359-4292-2023-0249

Drug repurposing and personalized treatment strategies for bipolar disorder using transcriptomics: an exploratory study transcriptomics
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Ziani, Paola Rampelotto

; de Bastiani, Marco Antônio

; Scotton, Ellen da Rosa, Pedro Henrique Schons, Tainá Mezzomo, Giovana de Carvalho, Quênia Kapczinski, Flávio Rosa, Adriane R.

Brazilian Journal of Psychiatry

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2024, Volume 46 elocation e20233441

Resumo: En | Texto: En | PDF: En

Objective: The present study combined transcriptomic data and computational techniques based on gene expression signatures to identify new bioactive compounds or Food and Drug Administration-approved drugs for the treatment of bipolar disorder (BD). Methods: Five transcriptomic datasets containing 165 blood samples from individuals with BD were selected from the Gene Expression Omnibus (GEO). The number of participants varied from six to 60, with a mean age between 35 and 48 years and a gender difference between them. Most of these patients were receiving pharmacological treatment. Master regulator analysis (MRA) and gene set enrichment analysis (GSEA) were performed to identify genes that were significantly different between patients with BD and healthy controls and their associations with mood states in patients with BD. In addition, molecules that could reverse the transcriptomic profiles of BD-altered regulons were identified from the Library of Network-Based Cellular Signatures Consortium (LINCS) and the Broad Institute Connectivity Map Drug Repurposing Database (cMap) databases. Results: MRA identified 59 candidate master regulators (MRs) that modulate regulatory units enriched with BD-altered genes. In contrast, GSEA identified 134 enriched genes and 982 regulons whose activation state was determined. Both analyses revealed genes exclusively associated with mania, depression, or euthymia, and some genes were shared among these three mood states. We identified bioactive compounds and licensed drug candidates, including antihypertensives and antineoplastic agents, as promising candidates for the treatment of BD. However, experimental validation is essential to confirm these findings in further studies. Conclusion: Although our data are still preliminary, they provide some insights into the biological patterns of different mood states in patients with BD and their potential therapeutic targets. The strategy of transcriptomics plus bioinformatics offers a way to advance drug discovery and personalized medicine by using gene expression information. Objective Administrationapproved Administration approved . (BD) Methods 16 GEO. GEO (GEO) 60 3 4 them (MRA (GSEA addition BDaltered altered NetworkBased Network Based LINCS (LINCS cMap (cMap databases Results 5 MRs (MRs contrast 13 98 determined mania depression euthymia agents However studies Conclusion preliminary targets information (BD 1 (GEO 6 9

https://doi.org/10.47626/1516-4446-2023-3441

Associations between intersectional relationships of oppression and domains of physical activity in the Vigitel study (2016-2020) 20162020 2016 2020 (2016-2020 2016202 201 202 (2016-202 201620 20 (2016-20 20162 2 (2016-2 (2016- (2016 (201 (20 (2 (
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Paiva, Giovana Barbosa de

; Araújo, Mariane Ferreira dos Santos

; Rodrigues, Phillipe Augusto Ferreira

; Carvalho, Pedro Henrique Melo de

; Oliveira, Francine de

; Corrêa Neto, Victor Gonçalves

; Palma, Alexandre

Revista Brasileira de Ciências do Esporte

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2024, Volume 46 elocation e20240044

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO A literatura recomenda a prática de atividade física (AF), independente do domínio. Contudo, a maioria dos estudos desconsidera as relações interseccionais de opressão. O objetivo do presente estudo é verificar as associações entre determinantes sociais e distintos domínios da atividade física (lazer, ocupacional, deslocamento e doméstico), especialmente a partir da perspectiva do índice de desvantagem, que traduz as relações interseccionais de opressão na pesquisa do Vigitel entre os anos de 2016 e 2020. A partir dos dados coletados, foi calculado o índice de jeopardy. Foi possível observar que a prática de AF no lazer é mais acentuada entre os grupos com menos opressão social. Por outro lado, os grupos mais oprimidos apresentaram maior envolvimento nos domínios de AF ocupacional, de deslocamento e doméstica. Conclui-se, portanto, que a noção de que qualquer AF é melhor do que ser inativo deveria ser revista. AF, , (AF) domínio Contudo lazer, (lazer ocupacional doméstico, doméstico doméstico) desvantagem 201 2020 coletados jeopardy social lado doméstica Concluise, Concluise Conclui se, se Conclui-se portanto revista (AF 20 202 2

ABSTRACT The literature recommends the practice of physical activity (PA), regardless of the domain. However, most studies ignore intersectional relations of oppression. The objective of the present study is to verify the associations between social determinants and distinct domains of physical activity (leisure-time, occupational, commuting, and domestic), especially from the perspective of the jeopardy index, which translates the intersectional relations of oppression in Vigitel´s research between the years of 2016 and 2020. From the data collected, the jeopardy index was calculated. It was possible to observe that the practice of PA during leisure time is more pronounced among groups with less social oppression. On the other hand, the most oppressed groups showed greater involvement in the domains of occupational, commuting and domestic PA. It is concluded, therefore, that the notion that any PA is better than being inactive should be reviewed. PA, , (PA) domain However leisuretime, leisuretime time, (leisure-time occupational domestic, domestic) Vigitels Vigitel s 201 2020 collected calculated hand concluded therefore reviewed (PA 20 202 2

RESUMEN La literatura recomienda la práctica de actividad física (AF), independientemente del dominio. Sin embargo, la mayoría de los estudios ignoran las relaciones interseccionales de opresión. El objetivo del presente estudio es verificar las asociaciones entre los determinantes sociales y los distintos dominios de la actividad física (tiempo libre, ocupacional, desplazamiento y doméstica), especialmente desde la perspectiva del índice de desventaja, que traduce las relaciones interseccionales de opresión en la investigación de Vigitel entre los años 2016 y 2020. A partir de los datos recolectados, se calculó el índice de desventaja. Se observó que la práctica de AF durante el tiempo libre es más pronunciada entre los grupos con menos opresión social. Por otro lado, los grupos más oprimidos mostraron un mayor involucramiento en los dominios de AF ocupacional, de desplazamiento y doméstica. Se concluye, por lo tanto, que la noción de que cualquier AF es mejor que la inactividad debe ser revisada. AF, , (AF) dominio embargo ocupacional doméstica, doméstica doméstica) desventaja 201 2020 recolectados social lado concluye tanto revisada (AF 20 202 2

https://doi.org/10.1590/rbce.46.e20240044

Technological Prospection and Scientific Innovation of Ilex paraguariensis Saint-Hilaire in the Wound Healing Process SaintHilaire Saint Hilaire
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Clemente, Pedro Augusto

; Mendonça, Kelby Cavalheiro

; Andrade, Giovana Frazon de

; Goncalves, Larisse Medeiros

; Godoy, Cristiane Maria Tonetto

; Rocha, Jhonatan Matheus Piaceski

; Silva, Weber Claudio Francisco Nunes da

; Reolon, Jéssica Brandão

; Ferreira, Daiane Finger

; Vieira, Maria Cristina Umpierrez

; Silva, Juliana Maria

; Ferreira, Luana Mota

; Bonini, Juliana Sartori

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24230086

Resumo: En | Texto: En | PDF: En

Abstract Natural compounds are possible alternatives for wound treatment, including Ilex paraguariensis, a plant with several pharmacological actions already reported, including anti-inflammatory, antibacterial, antioxidant, and healing activities. Therefore, this study aimed to perform a technological and scientific mapping of Ilex paraguariensis used for healing and/or analgesic purposes. Technological prospection was carried out in the Questel-Orbit system, while the scientific research was carried out in PubMed, Web of Science, and SCOPUS databases. The terms “Ilex paraguariensis”, “Yerba-mate”, “Painkiller”, “Analgesic”, “Wound”, “Healing”, and “Scar” were combined using Boolean operators “OR” and “AND”. The technological prospection resulted in 164 patents found initially. After sorting the abstracts, five patents were read entirely, of which three were selected. Such selected patents report using Ilex paraguariensis for analgesics, wound healing, personal care, and pharmaceutical applications. In addition, the scientific research showed a small number of studies aimed at using Ilex paraguariensis for healing and/or analgesic purposes. Among the 26 articles initially found, only 5 met the inclusion requirements. Scientific studies demonstrate that Ilex paraguariensis is used as an extract or drink, presenting promising results regarding analgesia, inflammation, and wound healing, using in vitro or in vivo models. Despite the potential of Ilex paraguariensis in skin wound therapy, our study demonstrates that few patents and scientific studies explore Ilex paraguariensis for this purpose. This fact may be an incentive for the development of further studies employing Ilex paraguariensis in cutaneous wound management and the pain associated with them. treatment reported antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory antibacterial antioxidant activities Therefore andor purposes QuestelOrbit Questel Orbit system PubMed Science databases , paraguariensis” Yerbamate, Yerbamate Yerba mate “Yerba-mate” Painkiller, Painkiller “Painkiller” Analgesic, Analgesic “Analgesic” Wound, Wound “Wound” Healing, Healing “Healing” Scar “Scar OR “OR AND. AND . “AND” 16 abstracts entirely analgesics care applications addition 2 requirements drink analgesia inflammation models therapy purpose them “Yerba-mate “Painkiller “Analgesic “Wound “Healing “AND 1

https://doi.org/10.1590/1678-4324-2024230086

Cytotoxic effects of crotoxin from Crotalus durissus terrificus snake in canine mammary tumor cell lines
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Pedro, Giovana

; Brasileiro, Felipe César da Silva

; Macedo, Jamile Mariano Soares, Andreimar Martins Mafra, Gabriel Caporale Alves, Carlos Eduardo Fonseca Laufer-Amorim, Renée

Journal of Venomous Animals and Toxins including Tropical Diseases

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2024, Volume 30 elocation e20230062

Resumo: En | Texto: En | PDF: En

Abstract Background: Mammary gland tumors are the most prevalent neoplasm in intact female dogs, and they are good natural models to study comparative oncology. Most canine mammary malignancies, as in women, are commonly refractory to conventional therapies and demand continuous new therapeutic approaches. Crotalus durissus terrificus, also called rattlesnake, has more than 60 different proteins in its venom with multiple pharmaceutical uses, such as antitumor, antiviral, and antimicrobial action. Crotoxin, a potent β-neurotoxin formed by the junction of two subunits, a basic subunit (CB-PLA2) and an acidic subunit (crotapotin), has already been reported to have anticancer properties in different types of cancers. Methods: In this work, we describe the cytotoxic potential of crotoxin and its subunits compared to doxorubicin (drug of choice) in two canine mammary carcinoma cell lines. Results: Crotoxin, CB-PLA2, crotalic venom, and doxorubicin decreased cell viability and the ability to migrate in a dose-dependent manner, and crotapotin did not present an antitumoral effect. For all compounds, the predominant cell death mechanism was apoptosis. In addition, crotoxin did not show toxicity in normal canine mammary gland cells. Conclusion: Therefore, this work showed that crotoxin and CB-PLA2 had cytotoxic activity, migration inhibition, and pro-apoptotic potential in canine mammary gland carcinoma cell lines, making their possible use in cancer research. Background dogs oncology malignancies women approaches terrificus rattlesnake 6 uses antitumor antiviral action Crotoxin βneurotoxin β neurotoxin CBPLA2 CBPLA CB PLA2 PLA (CB-PLA2 crotapotin, , (crotapotin) cancers Methods drug choice lines Results CBPLA2, PLA2, dosedependent dose dependent manner effect compounds apoptosis addition cells Conclusion Therefore CB-PLA activity inhibition proapoptotic pro apoptotic research (CB-PLA (crotapotin

https://doi.org/10.1590/1678-9199-jvatitd-2023-0062

Effect of the Incorporation of Bactericidal Agents Ag, Cu, and Zn Through Micro-arc Oxidation on the Properties of the Ti-25Ta Alloy Surface Ag Cu Microarc Micro arc Ti25Ta TiTa Ti 25Ta Ta
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Kuroda, Pedro Akira Bazaglia

; Cardoso, Giovana Collombaro

; Rossi, Mariana Correa

; Grandini, Carlos Roberto Afonso, Conrado Ramos Moreira

Materials Research

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2024, Volume 27 elocation e20230410

Resumo: En | Texto: En | PDF: En

The main objective of this paper is to produce an anodic layer of TiO2 rich in calcium, phosphorus, and magnesium using the anodizing technique known as micro-arc oxidation (MAO) on the Ti-25Ta alloy together with the incorporation of silver (Ag), copper (Cu) and zinc (Zn) metallic ions using different electrolytes. The structural changes and microstructures on the MAO surfaces were analyzed using the X-ray diffraction (XRD) technique and scanning electron microscopy (SEM). The chemical composition to verify whether silver, copper, and zinc were incorporated via energy dispersive spectroscopy (EDS) and surface characteristics such as wettability and hardness of the coatings were also investigated. From the EDS mapping results, it is observed that the MAO process was effective in incorporating the ions present in the electrolyte. Regarding X-ray diffraction patterns, the TiO2 phases formed in the Ti-25Ta alloy has a mixture of anatase and rutile, making the MAO surface hydrophilic. The Ag element surface is thicker than the films containing Cu and Zn, as the Ag ions have high electrical conductivity, accelerating the oxidation process during surface treatment. Regarding hardness, coating containing Cu have a higher hardness value. TiO calcium phosphorus microarc micro arc (MAO Ti25Ta TiTa Ti 25Ta Ta Ag, , (Ag) (Cu Zn (Zn electrolytes Xray X ray XRD (XRD SEM. SEM . (SEM) (EDS investigated results electrolyte patterns rutile hydrophilic conductivity treatment value (Ag (SEM

https://doi.org/10.1590/1980-5373-mr-2023-0410

Reproductive evaluation of Luisa, the last jaguar of the Caatinga
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Requena, Letícia Alecho

; Luczinski, Thiago Cavalheri

; Traldi, Anneliese de Souza

; Deco-Souza, Thyara de

; Araújo, Gediendson Ribeiro de

; Pizzutto, Cristiane Schilbach

; Miranda, Giovana Martins

; Porto, Mirna Ribeiro

; Silva, Maitê Cardoso Coelho da

; Jorge Neto, Pedro Nacib

Animal Reproduction

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2023, Volume 20 Nº 4 elocation e20230090

Resumo: En | Texto: En | PDF: En

Abstract The in situ population of jaguars in the Caatinga is less than 250 individuals, subdivided into five subpopulations, and is classified as endangered regarding its risk of extinction. Luisa, a 15-year-old female weighing 36 kg, was the last known ex situ jaguar from this biome. Her reproductive evaluation is detailed in this manuscript. Luisa was subjected to both a clinical and laparoscopic evaluation of her reproductive system. After 45 days of reproductive investigation, she died unexpectedly, and skin fragments were taken to establish the postmortem fibroblast lineage. At the clinical evaluation, Luisa had small, undeveloped mammary gland and a small vulva, characteristic of a nulliparous female, with no mammary gland nodules, edema, or abnormal masses. By laparoscopy, normal-appearing bladder and bowel loops were observed, as were uterine horns with standard color, shape, and length with no striae. Ovaries and uterine horns seem free of fibrinous adhesions. Both ovaries showed a yellowish color, a fibrous consistency, a decreased size (atrophied), and no follicles, hemorrhagic corpus, corpus luteum, luteal scars, or other abnormal structures. We may assume that this jaguar female was infertile based on Luisa's mature age and the absence of birthing or ovarian activity signs. The harsh conditions of the Caatinga biome, which included low food availability and frequent conflicts with humans, may have impacted both the pregnancy and lactation of Luisa’s mother and her development after birth.

https://doi.org/10.1590/1984-3143-ar2023-0090

Effect of speech therapy on quality of life in patients with spinocerebelar ataxia type 3
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Diaféria, Giovana

; Bommarito, Silvana

; Braga Neto, Pedro

; Park, Sung Woo

; Padovani, Marina

; Haddad, Fernanda

; Haddad, Leonardo

; Voos, Mariana Callil

; Chien, Hsin Fen

; Pedroso, José Luiz

; Barsottini, Orlando

Arquivos de Neuro-Psiquiatria

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Out 2022, Volume 80 Nº 10 Páginas 1017 - 1025

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes Indivíduos com ataxia espinocerebelar tipo 3 (AEC3) apresentam distúrbios da comunicação e deterioração da deglutição e, consequentemente, na qualidade de vida (QV). Objetivo Avaliar o impacto de um programa de reabilitação fonoaudiológica na QV em pacientes com AEC3. Métodos Todos os participantes foram alocados aleatoriamente em dois grupos, um grupo intervenção que recebeu terapia fonoaudiológica (GTF) e um grupo controle (GC). As pontuações das escalas: International Cooperative Ataxia Rating Scale (ICARS) foram 32,4 ± 20,2 e da Scale for the Assessment and Rating of Ataxia (SARA) foram 11,8 ± 8,0. A intervenção consistiu em um programa de reabilitação fonoaudiológica de 12 sessões composto por exercícios de fortalecimento oral, faríngeo e laríngeo - denominados ATAXIA - Terapia Miofuncional Orofacial e Vocal (A-TMOV). Todos foram submetidos a avaliações pré e pós-intervenção por meio dos protocolos World Health Organization's Quality of Life (WHOQOL-BREF), Vivendo com Disartria (VcD), Quality of Life in Swallowing Disorders (SWAL-QOL) e Food Assessment Tool (EAT-10). Resultados A amostra foi composta por 48 pacientes com AEC3 (25 no GTF e 23 no GC), média de idade 47,1 ± 11,4anos; média de idade de início dos sintomas 36,9 ± 11,3anos; duração da doença 11,9 ± 13,3anos. Após intervenção de três meses, houve mudanças significativas na QV no GTF em comparação com o GC quando avaliado pelo VcD (179,12 ± 62,55 versus129,88 ± 51,42, p < 0,001), SWAL-QOL (869,43 ± 153,63 versus 911,60 ± 130,90, p = 0,010), EAT-10 (5,16 ± 7,55 versus 2,08 ± 3,85, p = 0,018). Conclusões Pacientes com AEC3 devem receber terapia fonoaudiológica contínua como parte do programa A-TMOV, pois a terapia ajuda a melhorar a dificuldade de deglutição e a disartria. AEC (AEC3 consequentemente QV. . (QV) grupos (GTF GC. (GC) escalas ICARS (ICARS 324 32 4 32, 202 20 2 20, SARA (SARA 118 11 8 11, 80 0 8,0 1 oral ATMOV. ATMOV TMOV (A-TMOV) pósintervenção pós Organizations Organization s WHOQOLBREF, WHOQOLBREF WHOQOL BREF , (WHOQOL-BREF) VcD, (VcD) SWALQOL SWAL QOL (SWAL-QOL EAT10. EAT10 EAT 10 (EAT-10) 25 (2 GC, GC) 471 47 47, 11,4anos 114anos anos 4anos 369 36 9 36, 11,3anos 113anos 3anos 119 133anos 13 13,3anos meses 179,12 17912 179 (179,1 6255 62 55 62,5 versus12988 versus129 88 versus129,8 5142 51 42 51,42 0,001, 0001 0,001 001 0,001) 869,43 86943 869 43 (869,4 15363 153 63 153,6 91160 911 60 911,6 13090 130 90 130,90 0,010, 0010 0,010 010 0,010) EAT-1 5,16 516 5 16 (5,1 755 7 7,5 208 08 2,0 385 85 3,85 0,018. 0018 0,018 018 0,018) ATMOV, TMOV, A-TMOV disartria (AEC (QV (GC 8, (A-TMOV (WHOQOL-BREF (VcD EAT1 (EAT-10 ( 179,1 1791 17 (179, 625 6 62, versus1298 versus12 versus129, 514 51,4 000 0,00 00 869,4 8694 86 (869, 1536 15 153, 9116 91 911, 1309 130,9 0,01 01 EAT- 5,1 (5, 75 7, 2, 38 3,8 (EAT-1 179, (179 versus1 51, 0,0 869, (869 130, 5, (5 3, (EAT- (17 0, (86 (EAT (1 (8

Abstract Background Individuals with spinocerebellar ataxia type 3 (SCA3) present communication and swallowing disorders, and consequent deterioration in quality of life (QOL). Objective To evaluate the impact of a speech therapy rehabilitation program on the QOL of patients with SCA3. Methods All participants were randomly assigned to two groups, an intervention group receiving speech therapy (STG) and a control group (CG). The International Cooperative Ataxia Rating Scale scores were 32.4 ± 20.2, and the Scale for the Assessment and Rating of Ataxia scores were 11.8 ± 8.0. The intervention consisted of a 12-session speech therapy rehabilitation program with oral, pharyngeal, and laryngeal strengthening exercises—the so-called ATAXIA–Myofunctional Orofacial and Vocal Therapy (A-MOVT). They all were submitted to pre- and postintervention evaluations using the World Health Organization's Quality of Life (WHOQOL-BREF) assessment, as well as the Living with Dysarthria (LwD), Quality of Life in Swallowing Disorders (SWAL-QOL), and Food Assessment Tool (EAT-10). Results The study sample consisted of 48 patients with SCA3 (STG = 25; CG = 23), mean age was 47.1 ± 11.4 years; mean age at symptom onset was 36.9 ± 11.3 years; disease duration was 11.9 ± 13.3 years. After the 3-month intervention, there were significant changes in the QOL in the STG compared with the CG, when assessed by the LwD (179.12 ± 62.55 vs. 129.88 ± 51.42, p < 0.001), SWAL-QOL (869.43 ± 153.63 vs. 911.60 ± 130.90, p = 0.010), and EAT-10 (5.16 ± 7.55 vs. 2.08 ± 3.85, p = 0.018). Conclusions Patients with SCA3 should receive continuous speech therapy as part of the A-MOVT program, because therapy helps to improve difficulty swallowing and dysarthria. SCA (SCA3 disorders QOL. . (QOL) groups CG. (CG) 324 32 4 32. 202 20 2 20.2 118 11 8 11. 80 0 8.0 12session session 12 oral pharyngeal exercisesthe exercises socalled so called ATAXIAMyofunctional ATAXIA Myofunctional AMOVT. AMOVT A MOVT (A-MOVT) pre Organizations Organization s WHOQOLBREF WHOQOL BREF (WHOQOL-BREF assessment LwD, , (LwD) SWALQOL, SWALQOL SWAL (SWAL-QOL) EAT10. EAT10 EAT 10 (EAT-10) 25 23, 23 23) 471 47 1 47. 114 years 369 36 9 36. 113 119 133 13 13. 3month month 179.12 17912 179 (179.1 6255 62 55 62.5 vs 12988 129 88 129.8 5142 51 42 51.42 0.001, 0001 0.001 001 0.001) 869.43 86943 869 43 (869.4 15363 153 63 153.6 91160 911 60 911.6 13090 130 90 130.90 0.010, 0010 0.010 010 0.010) EAT-1 5.16 516 5 16 (5.1 755 7 7.5 208 08 2.0 385 85 3.85 0.018. 0018 0.018 018 0.018) dysarthria (SCA (QOL (CG 20. 8. (A-MOVT (LwD (SWAL-QOL EAT1 (EAT-10 179.1 1791 17 (179. 625 6 62. 1298 129. 514 51.4 000 0.00 00 869.4 8694 86 (869. 1536 15 153. 9116 91 911. 1309 130.9 0.01 01 EAT- 5.1 (5. 75 7. 2. 38 3.8 (EAT-1 179. (179 51. 0.0 869. (869 130. 5. (5 3. (EAT- (17 0. (86 ( (EAT (1 (8

https://doi.org/10.1055/s-0042-1755203

10.

Analysis of trends in sepsis mortality in Brazil and by regions from 2010 to 2019
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Almeida, Nyara Rodrigues Conde de

; Pontes, Giovana Fonseca

; Jacob, Felipe Lima

; Deprá, João Victor Salvador

; Porto, João Pedro Pires

; Lima, Fernanda Rocha de

; Albuquerque, Mário Roberto Tavares Cardoso de

Revista de Saúde Pública

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2022, Volume 56 elocation 25

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Caracterizar o perfil dos pacientes internados e a tendência de mortalidade por sepse no Sistema Único de Saúde (SUS), em todo Brasil e em suas regiões separadamente, entre os anos de 2010 e 2019. MÉTODOS Estudo observacional, analítico e retrospectivo de dados secundários obtidos por consulta ao Sistema de Informação Hospitalar. Foram incluídas todas as notificações por septicemia admitidas entre 1 de janeiro de 2010 e 31 de dezembro de 2019. Utilizou-se as variáveis sociodemográficas: sexo, idade, raça, região e unidade federativa de residência. Para a análise dos dados, utilizou-se coeficiente de mortalidade e de internação, risco relativo e regressão por Joinpoints. RESULTADOS Totalizaram-se 1.044.227 casos de sepse no país, perfazendo um coeficiente de prevalência média de 51,3/100 mil habitantes. Foram registrados 463 mil óbitos por sepse, com coeficiente médio de 22,8 óbitos/100 mil habitantes. As maiores taxas ocorreram entre os idosos, de raça parda e não houve uma diferença significativa entre os sexos. A Região Sudeste foi responsável pelo maior índice de internação e óbitos. Observou-se uma tendência geral de aumento da mortalidade no período estudado. CONCLUSÃO Cabe considerar a heterogeneidade do Brasil, no que concerne às características socioeconômicas e demográficas e às diferenças de investimento em saúde e de subnotificações entre as regiões, a fim de entender o traçado epidemiológico da doença. Por fim, é necessário correlacionar esses achados com demais estudos, buscando entendimento do comportamento da doença e embasamento para políticas públicas e privadas, com intuito de diminuir a expressividade de casos e óbitos por sepse no país.

ABSTRACT OBJECTIVE To characterize the profile of inpatients and trend of sepsis mortality in the Brazilian Unified Health System (SUS), throughout Brazil, and in its regions separately, from 2010 to 2019. METHODS Observational, analytical and retrospective study of secondary data obtained through consultation to the Sistema de Informação Hospitalar (Hospital Information System). All incoming septicemia notifications from January 1, 2010 to December 31, 2019 were included. The following sociodemographic variables were used: sex, age, race, region and federative unit of residence. For data analysis, we used mortality and hospitalization coefficient, relative risk and Joinpoint regression. RESULTS There were a total of 1,044,227 cases of sepsis in Brazil, yielding a mean prevalence coefficient of 51.3/100 thousand inhabitants. There were 463,000 deaths from sepsis recorded, with a mean prevalence coefficient of 22.8 deaths/100,000 inhabitants. The highest rates occurred among the elderly, of brown race, and there was no significant difference between genders. The Southeast region accounted for the highest rates of hospitalization and deaths. A general trend toward increased mortality was observed in the period studied. CONCLUSION The heterogeneity of Brazil should be considered regarding socioeconomic and demographic characteristics, and differences in health investment and underreporting between regions, in order to understand the disease’s epidemiological course. Finally, these findings should be correlated with other studies, in an effort to understand the behavior of the disease, and provide inputs for public and private policies in order to reduce the expressiveness of cases and deaths from sepsis in Brazil.

https://doi.org/10.11606/s1518-8787.2022056003789

11.

Analysis of trends in sepsis mortality in Brazil and by regions from 2010 to 2019
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Almeida, Nyara Rodrigues Conde de

; Pontes, Giovana Fonseca

; Jacob, Felipe Lima

; Deprá, João Victor Salvador

; Porto, João Pedro Pires

; Lima, Fernanda Rocha de

; Albuquerque, Mário Roberto Tavares Cardoso de

Revista de Saúde Pública

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2022, Volume 56 elocation 25

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2022056003789

12.

Impacto antrópico na dinâmica de uma floresta nebular do planalto catarinense
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Stuani, Giovana Reali

; Silva, Ana Carolina da

; Higuchi, Pedro

; Larsen, Janaina Gabriela

; Machado, Felipe Domingos

; Santos, Guilherme Neto dos

Ciência Florestal

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Dez 2021, Volume 31 Nº 4 Páginas 1714 - 1732

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo do presente estudo foi investigar a dinâmica da comunidade arbórea adulta e regenerante em um fragmento de Floresta Nebular em Urubici, Santa Catarina, sujeito ao impacto de gado. Os inventários dos indivíduos arbóreos adultos (diâmetro na altura do peito - DAP ≥ 5 cm) foram realizados em 2011, 2015 e 2019, e dos regenerantes arbóreos (DAP < 5 cm), em 2013, 2015, 2017 e 2019. Para o componente adulto, a amostragem foi realizada em 25 parcelas de 20 × 20 m alocadas de forma sistemática no fragmento. Em cada uma dessas parcelas também foram coletadas variáveis edáficas e topográficas. O componente regenerativo arbóreo foi avaliado em subparcelas conforme classe de tamanho das plantas (classe 1: plantas com altura de 0,15 cm até 1 m, em 5 m2; classe 2: plantas com altura acima de 1 m e até 3 m, em 10 m2, e classe 3: plantas com altura maior que 3 m e DAP < 5 cm, em 20 m2). Foram calculadas as taxas demográficas para a comunidade e as populações de indivíduos adultos e regenerantes. Utilizaram-se Árvores de Regressão (AR), para testar a influência das variáveis ambientais sobre as taxas de dinâmica dos regenerantes, e Análises dos Componentes Principais (PCA), para sintetizar os gradientes representados pelas taxas de dinâmica entre populações. No último período, 2015-2019, a floresta apresentou perda em indivíduos e em área basal, o que sugere um processo de desestruturação. Para os indivíduos regenerantes, as variáveis mais influentes na dinâmica estiveram relacionadas com a fertilidade do solo, os teores de H+Al, a cota altitudinal e a compactação dos solos. Para a conservação da área, medidas, como o cercamento contra entrada de gado, são essenciais para a manutenção da floresta ao longo do tempo.

Abstract The objective of this research was to investigate the dynamics of the adult and regenerating tree community in a Cloud Forest fragment in Urubici, Santa Catarina, subject to livestock impact. Inventories of adult tree individuals were carried out in 2011, 2015, and 2019, and of regenerative trees, in 2013, 2015, 2017, and 2019. For the adult component, sampling was performed within 25 20 x 20 m systematically allocated plots. Within each plot, soil and topographic variables were also collected. The regenerative component was evaluated in subplots according to plant size classes (class 1: plants with a height from 0.15 cm to 1 m in 5 m2; class 2: plants with height above 1 m and up to 3 m in 10 m2; and class 3: plants with height above 3 m and DAP < 5 cm in 20 m2). The demographic rates for the community of adult and regenerating individuals were determined. Regression Trees (RT) were used to test the influence of environmental variables on the dynamics rates of the regenerative component, and Principal Component Analysis (PCA) was performed to synthesize the population dynamics rates. In the last period, 2015-2019, the forest showed a loss of individuals and basal area, which suggests a de-structuring process. For regenerating individuals, the most influential variables in the dynamics were soil fertility, H+Al levels, altitudinal quota, and soil compaction. For the conservation of the area, measures such as fencing to prevent cattle from entering are essential for the maintenance of the forest over time.

https://doi.org/10.5902/1980509842667

13.

Presence and persistence of Pseudomonas sp. during Caspian Sea-style spontaneous milk fermentation highlights the importance of safety and regulatory concerns for traditional and ethnic foods
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MASKE, Bruna Leal

; PEREIRA, Gilberto Vinícius de Melo CARVALHO NETO, Dão Pedro de LINDNER, Juliano de Dea LETTI, Luiz Alberto Júnior PAGNONCELLI, Maria Giovana SOCCOL, Carlos Ricardo

Food Science and Technology

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Jun 2021, Volume 41 Páginas 273 - 283

Resumo: En | Texto: En | PDF: En

Abstract The aim of this study was to evaluate the performance of Caspian Sea-style spontaneous milk fermentation to improve the quality of pasteurized milk containing high levels of Pseudomonas contamination, with a focus on microbiological safety and stability of the final product. Bacterial diversity of pasteurized milk, fermentation process, and after 60 days of storage was analyzed by Illumina-based sequencing, and presence of viable taxa was confirmed by culturing on selective media. Low quality pasteurized milk harbored mainly Gram-negative bacteria, markedly dominated by Pseudomonas. Following fermentation, lactic acid bacteria rapidly became dominant with maximum population of 10.15 log CFU/mL at 18 h, represented mainly by Lactococcus. However, sequences related to Pseudomonas, and to a lesser extent for enterobacteria, remained constant throughout the fermentation process. The cultured-dependent approach confirmed the presence of viable Pseudomonas, with a final population of 5.60 log CFU/mL. Biochemical transformations were further analyzed, indicating lactic acid as the main end-metabolite produced (maximum concentration of 5.93 g/L at 24 h). In addition, the increase of 2-nonanone can be correlated as a volatile biomarker of P. aeruginosa and related species. Altogether, the results demonstrated that natural milk fermentation may often not inhibit the development of pathogens and food spoilage microorganisms.

https://doi.org/10.1590/fst.15620 383 downloads

14.

Burnout Syndrome and Consumption of Alcohol and Illicit Substances in University Students
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Andrade, Giovana Frazon

; Menolli, Poliana Vieira da Silva

; Clemente, Pedro Augusto

; Mesas, Arthur Eumann

; Silva, Dannyele Cristina

; Girotto, Edmarlon

Paidéia (Ribeirão Preto)

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2021, Volume 31 elocation e3134

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo O consumo de álcool e substâncias ilícita tem apresentado níveis alarmantes entre jovens universitários, e seu uso pode estar associado à estratégia de enfrentamento do burnout acadêmico. Esta revisão teve por objetivo sintetizar as evidências científicas relacionadas ao consumo de álcool e substâncias ilícitas associadas a síndrome de burnout em estudantes universitários. Foram realizadas buscas nas bases: Biblioteca Virtual em Saúde, PubMed, Web of Science, PsycNet e Scopus, sem limitação de ano e baseado na guia PRISMA. Entre os 2.269 artigos identificados, 16 atenderam aos critérios de inclusão. Todos os estudos avaliaram estudantes da área da saúde, 12 estudos encontraram associação entre as variáveis, sendo o consumo de álcool e substâncias ilícitas fortemente relacionado à sindrome de burnout. Concluiu-se que há associação entre as variáveis estudadas, indicando que a presença da síndrome de burnout em universitários pode resultar no uso de estratégias negativas como medida de enfrentamento.

Abstract The consumption of alcohol and illicit substances has shown alarming levels among young university students, and its use may be associated with the coping strategy of academic burnout. This review aimed to synthesize the scientific evidence related to the consumption of alcohol and illicit substances associated with burnout syndrome in university students. Searches were carried out in: Biblioteca Virtual em Saúde, PubMed, Web of Science, PsycNet and Scopus databases, with no year limitation and based on the PRISMA guideline. Among the 2.269 articles identified, 16 met the inclusion criteria. All studies evaluated students in the health area, 12 studies found an association between the variables, with alcohol and illicit substances consumption strongly related to burnout syndrome. It was concluded that there is an association between the studied variables, indicating that the presence of burnout syndrome in university students can result in the use of negative strategies as a coping measure.

Resumen El consumo de alcohol y de sustancias ilícitas ha mostrado niveles alarmantes entre los jóvenes universitarios, y su uso puede estar asociado con estrategias de enfrentamiento del burnout académico. Esta revisión tuvo como objetivo sintetizar la evidencia científica relacionada con el consumo de alcohol y de sustancias ilícitas asociadas al síndrome de burnout en estudiantes universitarios. Las búsquedas se realizaron en las bases Biblioteca Virtual en Salud, PubMed, Web of Science, PsycNet y Scopus, sin limitación de año y basándose en la guía PRISMA. De los 2.269 artículos encontrados, 16 cumplieron los criterios de inclusión. Todos los estudios evaluaron estudiantes del área de salud y 12 estudios encontraron asociación entre las variables, entre los que el consumo de alcohol y de sustancias ilícitas estuvo fuertemente relacionado con el síndrome de burnout. Se concluyó que existe asociación entre las variables estudiadas, indicando que la presencia de síndrome de burnout en estudiantes universitarios puede resultar en el uso de estrategias negativas como medida de enfrentamiento.

https://doi.org/10.1590/1982-4327e3134 3 downloads

15.

COMVC-19: A Program to protect healthcare workers’ mental health during the COVID-19 Pandemic. What we have learned
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Fukuti, Pedro

; Uchôa, Caroline Louise Mesquita

; Mazzoco, Marina Flaborea

; Cruz, Isabella D'Andrea Garcia da

; Echegaray, Mariana V.F.

; Humes, Eduardo de Castro

; Silveira, Júlia Belizário

; Santi, Talita Di

; Miguel, Euripedes Constantino

; Corchs, Felipe

; Fatori, Daniel Campello, Guilherme Oliveira, Gabriel M. de Argolo, Felipe C. Ferreira, Felipe de M. Machado, Gustavo Argeu, Adriana Oliveira, Graça Maria Ramos de Serafim, Antônio de Pádua Siqueira, Luciana de Lima Rossi, Luciane de Rios, Izabel Cristina Oliveira, Talita Rodrigues de Antoniazzi, Leilane C. K. Gagliotti, Daniel Augusto Mori Abelama Neto, Emílio Oliveira Junior, Paulo Novais de Correia, Aline Villalobo Gonçalves, Luca Schilling Tortato, Liana Silva Busato, Wagner Machado Moraes Guimarães-Fernandes, Flávio Alves, Marcos Leite Netto, Oswaldo Ferreira Schoueri, Patrícia de Campos Lindenberg Roque, Márcio de Assis Merlin, Silvia Stahl Boer, Giovana Cardoso Machado Sallet, Paulo Clemente Malbergier, André Spedo, Mariana Abrahão Kamitsuji, Carla Satie Faria, Elizabeth de Moreira, Moacyr Vergara de Godoy Kaufman, Arthur Abdo, Carmita Scanavino, Marco de Tubino Lancman, Selma Tavares, Hermano Polanczyk, Guilherme Brunoni, André R. Forlenza, Orestes V. Barros-Filho, Tarcísio Eloy Pessoa de

Clinics

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2021, Volume 76 elocation e2631

Resumo: En | Texto: En | PDF: En

OBJECTIVE: In 2020, the COVID-19 pandemic brought a work and stress overload to healthcare workers, increasing their vulnerability to mental health impairments. In response, the authors created the COMVC-19 program. The program offered preventive actions and mental health treatment for the 22,000 workers of The Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP). This paper aims to describe its implementation and share what we have learned from this experience. METHODS: Workers were able to easily access the program through a 24/7 hotline. Additionally, a mobile phone app that screened for signs and symptoms of emotional distress and offered psychoeducation and/or referral to treatment was made available. Data from both these sources as well as any subsequent psychiatric evaluations were collected. RESULTS: The first 20 weeks of our project revealed that most participants were female, and part of the nursing staff working directly with COVID-19 patients. The most frequently reported symptoms were: anxiety, depression and sleep disturbances. The most common diagnoses were Adjustment, Anxiety, and Mood disorders. CONCLUSIONS: Implementing a mental health program in a multimodal intervention was feasible in a major quaternary public hospital. Our data also suggests that preventive actions should primarily be aimed at anxiety and depression symptoms, with a particular focus on the nursing staff.

https://doi.org/10.6061/clinics/2021/e2631

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