Abstract This study evaluated the median lethal concentration of silver nanoparticles and their effects in fish tambaqui Colossoma macropomum. Therefore, an acute toxicity assay was carried out in completely randomized design evaluating six different concentrations of silver nanoparticles on blood parameters of tambaqui. The silver nanoparticles were produced by chemical reduction with polyvinyl alcohol (AgNP-PVA). The lethal concentration 50% (LC50) was estimated using probit regression. The blood was collected, analyzed and the data were submitted to T-test (dying x surviving fish) and Tukey test (surviving fish). An increase in glucose, hematocrit, total plasma protein, hemoglobin, erythrocytes, leukocytes, monocytes, and neutrophils as well as reduced MCV (mean corpuscular volume) in dying fish compared to surviving fish were observed. Survived fish exposed to 187.5 µg/L showed an increase in hematocrit, MCV, and MCH and a reduction in erythrocytes, total numbers of leukocyte, thrombocyte, lymphocyte, and neutrophil. The fish exposed to concentrations below 125 µg/L, had returned the blood parameter to baselines compared to control. The estimated LC50 was 165.09 µg/L and was classified as highly toxic for the fish tambaqui. In higher concentrations, it causes an acute respiratory toxicity, but in concentrations below 125 µg/L, the fish can adapt to the stressing agent. macropomum Therefore AgNPPVA. AgNPPVA AgNP PVA . (AgNP-PVA) 50 LC (LC50 regression collected Ttest T fish. glucose hematocrit protein hemoglobin erythrocytes leukocytes monocytes mean volume observed 1875 187 5 187. µgL µg L leukocyte thrombocyte lymphocyte neutrophil 12 control LC5 16509 165 09 165.0 agent (AgNP-PVA (LC5 18 1 1650 16 0 165. (LC

Abstract Paraquat (1,1’-dimethyl-4,4’-bipyridyl dichloride) is an herbicide widely used worldwide and officially banned in Brazil in 2020. Kidney lesions frequently occur, leading to acute kidney injury (AKI) due to exacerbated reactive O2 species (ROS) production. However, the consequences of ROS exposure on ionic transport and the regulator local renin-angiotensin-aldosterone system (RAAS) still need to be elucidated at a molecular level. This study evaluated how ROS acutely influences Na+-transporting ATPases and the renal RAAS. Adult male Wistar rats received paraquat (20 mg/kg; ip). After 24 h, we observed body weight loss and elevation of urinary flow and serum creatinine. In the renal cortex, paraquat increased ROS levels, NADPH oxidase and (Na++K+)ATPase activities, angiotensin II-type 1 receptors, tumor necrosis factor-α (TNF-α), and interleukin-6. In the medulla, paraquat increased ROS levels and NADPH oxidase activity but inhibited (Na++K+)ATPase. Paraquat induced opposite effects on the ouabain-resistant Na+-ATPase in the cortex (decrease) and medulla (increase). These alterations, except for increased serum creatinine and renal levels of TNF-α and interleukin-6, were prevented by 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (tempol; 1 mmol/L in drinking water), a stable antioxidant. In summary, after paraquat poisoning, ROS production culminated with impaired medullary function, urinary fluid loss, and disruption of Na+-transporting ATPases and angiotensin II signaling. 1,1dimethyl4,4bipyridyl 11dimethyl44bipyridyl dimethylbipyridyl 1,1 dimethyl 4,4 bipyridyl 4 dichloride 2020 occur AKI (AKI O (ROS However reninangiotensinaldosterone renin aldosterone RAAS (RAAS level Na+transporting Natransporting Na+ transporting Na 20 (2 mg/kg mgkg mg kg ip. ip . ip) 2 h Na++K+ATPase NaKATPase Na++K+ ATPase K activities IItype type receptors factorα factor α TNFα, TNFα TNF , (TNF-α) interleukin6. interleukin6 interleukin 6. 6 interleukin-6 Na++K+ATPase. ATPase. ouabainresistant ouabain resistant Na+ATPase NaATPase decrease (decrease increase. increase (increase) alterations interleukin6, 6, 4hydroxy2,2,6,6tetramethylpiperidin1oxyl 4hydroxy2266tetramethylpiperidin1oxyl hydroxytetramethylpiperidinoxyl hydroxy 2,2,6,6 tetramethylpiperidin oxyl tempol (tempol mmolL mmol L water, water water) antioxidant summary poisoning function signaling 1dimethyl4 4bipyridyl 11 1, 44 4, 202 ( NaK Na++K (TNF-α interleukin- (increase 4hydroxy2 6tetramethylpiperidin1oxyl 2266 2,2,6, 1dimethyl 4hydroxy tetramethylpiperidinoxyl 226 2,2,6 22 2,2, 2,2 2,

ABSTRACT The objective of this study was to examine the effect of the increasing levels of inclusion of palm kernel cake (PKC) in the diet on the performance of feedlot heifers. Forty-eight Nelore heifers with an initial weight of 274 ± 4.58 kg, at 24 months of age, were confined for 98 days in a feedlot. The animals were allocated to the four treatments in a completely randomized design. Treatments consisted of PKC levels of 0 (control), 10, 20, and 30% in the total dry matter of the diet. The roughage:concentrate ratio in the diets was 30:70. Ether extract intake increased, whereas the intakes of non-fiber carbohydrates and total digestible nutrients decreased with the inclusion of PKC. The apparent digestibility of all nutrients decreased, as well as the amounts of nitrogen digested and retained. Microbial protein synthesis and its efficiency also declined. The inclusion of up to 20% PKC increased feeding time and reduced rumination time of heifers. Intake and rumination efficiencies decreased with the inclusion of PKC in the diet. Final weight and average daily gain did not change, but feed efficiency increased with the inclusion of PKC. The inclusion of up to 30% PKC in the diet of feedlot heifers is recommended. (PKC Fortyeight Forty eight 27 458 4 58 4.5 kg 2 age 9 design control, control , (control) 10 20 30 roughageconcentrate roughage concentrate 3070. 3070 70. 70 30:70 nonfiber non fiber retained declined change recommended 45 5 4. (control 1 3 307 7 30:7 30:

ABSTRACT This article aims to present the results of the Niterói Bicycle Policy Evaluability study. It is a pre-evaluative approach whose methodological path adopted the following steps: i) Document analysis; ii) Construction of the theoretical-logical model; iii) Agreement on the model with interested actors; iv) Definition of evaluative questions. The study made it possible to present a feasible, measurable and realistic design of the policy with the following dimensions: Urban Mobility, Safety and Cycle Education, Accountability and Healthy and Sustainable City. The importance of spreading monitoring and evaluation actions is reinforced here as an essential movement to strengthen the cyclomobility policy as an alternative transport and health promoter. preevaluative pre steps i analysis ii theoreticallogical theoretical logical iii actors iv questions feasible dimensions Mobility Education City promoter

RESUMEN Este artículo tiene como objetivo presentar los resultados del estudio de Evaluabilidad de la Política de Bicicletas de Niterói. Se trata de un enfoque preevaluativo cuyo recorrido metodológico adoptó los siguientes pasos: i) Análisis de documentos; ii) Construcción del modelo teórico-lógico; iii) Acuerdo sobre el modelo con los actores interesados; iv) Definición de preguntas evaluativas. El estudio permitió presentar un diseño factible, medible y realista de la política con las siguientes dimensiones: Movilidad Urbana, Seguridad y Educación Ciclista, Rendición de Cuentas y Ciudad Saludable y Sostenible. Se refuerza aquí la importancia de difundir acciones de seguimiento y evaluación como un movimiento imprescindible para fortalecer la política de ciclomovilidad como transporte alternativo y promotor de la salud. Niterói pasos i documentos ii teóricológico teórico lógico teórico-lógico iii interesados iv evaluativas factible dimensiones Urbana Ciclista Sostenible salud

RESUMO Esse artigo tem como objetivo apresentar os resultados do estudo de Avaliabilidade da Política Niterói de Bicicleta. Trata-se de uma abordagem pré-avaliativa cujo caminho metodológico adotou como etapas: i) Análise documental; ii) Construção do modelo teórico-lógico; iii) Pactuação do modelo com os atores interessados; iv) Definição das perguntas avaliativas. O estudo permitiu apresentar um desenho factível, mensurável e realista da política com as seguintes dimensões: Mobilidade Urbana, Segurança e Educação Cicloviária, Accountability e Cidade Saudável e Sustentável. Reforça-se aqui a importância de capilarizar ações de monitoramento e avaliação como um movimento indispensável ao fortalecimento da política de ciclomobilidade como transporte alternativo e promotor da saúde. Bicicleta Tratase Trata se préavaliativa pré avaliativa etapas i documental ii teóricológico teórico lógico teórico-lógico iii interessados iv avaliativas factível dimensões Urbana Cicloviária Sustentável Reforçase Reforça saúde

ABSTRACT. The objective of this work was to evaluate the non-carcass components of crossbred Santa Inês lambs finished in feedlot with the inclusion of different levels of red propolis extract (RPE). Thirty-five crossbred lambs were used with an average weight of 17.08 ± 2.36 kg and mean age of five months, distributed in a completely randomized design with five treatments and seven replications. The treatments evaluated were: 0; 7; 14 and 21 mL of extract/animal/day Before slaughter, each animal was individually weighed to obtain the body weight at slaughter (BWS). The weights and yields of non-carcass components were evaluated, weights and yields of regional dishes (Buchada and Panelada). The addition of different levels of red propolis extract (RPE) did not influence (p > 0.05) the weights and yields of non-carcass components, by-products and adipose deposits, to the weight and yield of regional dishes. The use of red propolis extract in diets up to the level studied (28 mL day-1) did not change the characteristics evaluated. ABSTRACT noncarcass non carcass RPE. RPE . Thirtyfive Thirty 1708 17 08 17.0 236 2 36 2.3 months replications 0 7 1 extractanimalday day BWS. BWS (BWS) Buchada Panelada. Panelada Panelada) (RPE p 0.05 005 05 byproducts by products deposits 28 (2 day1 day-1 170 17. 23 3 2. (BWS 0.0 00 ( day- 0.

Abstract Maternal endotoxemia disturbs the intrauterine environment, impairs nephrogenesis, and increases the risk of hypertension and kidney disease in adulthood. Here, it was investigated whether maternal treatment with the water extract of Moringa oleifera seeds (WEMoS) or the water-soluble M. oleifera seed lectin (WSMoL) prevents the oxidative stress induced by lipopolysaccharide (LPS) in pregnant rats, and the renal injury and hypertension in the adult offspring. The administration of WEMoS or WSMoL prevented the stimulatory effects of LPS on lipid peroxidation in the maternal-placenta-fetuses environment. The impact of WEMoS was linked to decreased superoxide anions production in the placenta. The effects of WSMoL were parallel to the inhibition of superoxide anion production and NADPH oxidase activity. The WSMoL also prevented increased NADPH oxidase activity in the fetal kidney. The LPS offspring presented higher systolic blood pressure (SBP) and increased lipid peroxidation, reactive oxygen species (ROS), NADPH oxidase activity, and nitrate/nitrite in the kidney; the maternal treatment with WEMoS and WSMoL prevented these changes. In conclusion, the present study demonstrates that WEMoS and WSMoL have protective effects on maternal endotoxemia, which involve antioxidant and anti-inflammatory actions that prevent the programming of hypertension. environment nephrogenesis adulthood Here (WEMoS watersoluble soluble M (WSMoL (LPS rats maternalplacentafetuses placenta fetuses SBP (SBP ROS, ROS , (ROS) nitratenitrite nitrate nitrite changes conclusion antiinflammatory anti inflammatory (ROS

Abstract Objective: The aim of this study was to analyze and identify documented infections and possible risk factors for Clostridioides difficile infections in children with cancer. Methods: This is a retrospective case-control study, carried out in a pediatric cancer hospital, covering the years 2016–2019. Matching was performed by age and underlying disease, and for each case, the number of controls varied from 1 to 3. Logistic regression models were used to assess risk factors. Results: We analyzed 63 cases of documented infection by C. difficile and 125 controls. Diarrhea was present in all cases, accompanied by fever higher than 38°C in 52.4% of the patients. Mortality was similar among cases (n=4; 6.3%) and controls (n=6; 4.8%; p=0.7). In all, 71% of patients in the case group and 53% in the control group received broad-spectrum antibiotics prior to the infection. For previous use of vancomycin, the Odds Ratio for C. difficile infection was 5.4 (95% confidence interval [95%CI] 2.3–12.5); for meropenem, 4.41 (95%CI 2.1–9.2); and for cefepime, 2.6 (95%CI 1.3–5.1). For the antineoplastic agents, the Odds Ratio for carboplatin was 2.7 (95%CI 1.2–6.2), melphalan 9.04 (95%CI 1.9–42.3), busulfan 16.7 (95%CI 2.1–134.9), and asparaginase 8.97 (95%CI 1.9–42.9). Conclusions: C. difficile symptomatic infection in children with cancer was associated with previous hospitalization and the use of common antibiotics in cancer patients, such as vancomycin, meropenem, and cefepime, in the last 3 months. Chemotherapy drugs, such as carboplatin, melphalan, busulfan, and asparaginase, were also risk factors. Objective Methods casecontrol hospital 20162019 2016 2019 2016–2019 disease Results 6 C 12 38C 38 524 52 4 52.4 n=4 n4 n (n=4 6.3% n=6 n6 (n=6 4.8% 48 8 p=0.7. p07 p p=0.7 . 0 7 p=0.7) 71 53 broadspectrum broad spectrum vancomycin 54 5 5. 95% 95 (95 95%CI 95CI CI [95%CI 2.3–12.5 23125 2 2.3–12.5) meropenem 441 41 4.4 2.1–9.2 2192 9 2.1–9.2) cefepime 26 2. 1.3–5.1. 1351 1.3–5.1 1.3–5.1) agents 27 1.2–6.2, 1262 1.2–6.2 , 1.2–6.2) 904 04 9.0 1.9–42.3, 19423 1.9–42.3 42 1.9–42.3) 167 16 16. 2.1–134.9, 211349 2.1–134.9 134 2.1–134.9) 897 97 8.9 1.9–42.9. 19429 1.9–42.9 1.9–42.9) Conclusions months drugs 2016201 201 2016–201 52. n= (n= 6.3 4.8 p0 p=0. (9 2.3–12. 2312 44 4. 2.1–9. 219 135 1.3–5. 126 1.2–6. 90 9. 1942 1.9–42. 21134 2.1–134. 13 89 8. 201620 20 2016–20 (n 6. p=0 ( 2.3–12 231 2.1–9 21 1.3–5 1.2–6 194 1.9–42 2113 2.1–134 20162 2016–2 p= 2.3–1 23 2.1– 1.3– 1.2– 19 1.9–4 211 2.1–13 2016– 2.3– 2.1 1.3 1.2 1.9– 2.1–1 2.3 1. 1.9

RESUMO Objetivo: Analisar e identificar infecções documentadas e possíveis fatores de risco para infecções por Clostridioides difficile em crianças com câncer. Métodos: Estudo retrospectivo caso-controle em um hospital pediátrico oncológico, que abrangeu os anos de 2016–2019. O pareamento foi realizado por idade e doença de base e, para cada caso, o número de controles variou de um a três. Modelos de regressão logística foram utilizados para avaliar os fatores de risco. Resultados: Analisamos 63 casos de infecção documentados por C. difficile e 125 controles. A diarreia esteve presente em todos os casos, acompanhada de febre acima de 38°C em 52,4% dos pacientes. A mortalidade foi semelhante entre casos (n=4, 6,3%) e controles (n=6, 4,8%; p=0,7). No grupo caso, 71% dos pacientes e, no grupo controle, 53% deles receberam antibióticos de amplo espectro antes da infecção. Para uso prévio de vancomicina, a Odds Ratio para infecção por C. difficile foi de 5,4 (intervalo de confiança [IC95%] 2,3–12,5); para meropenem, 4,41 (IC95% 2,1–9,2) e, para cefepima, 2,6 (IC95% 1,3–5,1). Para os agentes antineoplásicos, a razão de chances para carboplatina foi de 2,7 (IC95% 1,2–6,2), para melfalano de 9,04 (IC95% 1,9-42,3), para bussulfano de 16,7 (IC95% 2,1–134,9) e, para asparaginase, de 8,97 (IC95% 1,9–42,9). Conclusões: A infecção sintomática por C. difficile em crianças com câncer associou-se à internação prévia e ao uso de antibióticos como vancomicina, meropenem e cefepime nos últimos três meses. Os quimioterápicos carboplatina, melfalano, bussulfano e asparaginase também foram fatores de risco. Objetivo Métodos casocontrole caso controle oncológico 20162019 2016 2019 2016–2019 Resultados 6 C 12 38C 38 524 52 4 52,4 n=4, n4 n (n=4 6,3% 3 n=6, n6 (n=6 4,8% 48 8 p=0,7. p07 p p=0,7 . 0 7 p=0,7) 71 53 vancomicina 54 5 5, intervalo IC95% IC95 IC [IC95% 2,3–12,5 23125 2 2,3–12,5) 441 41 4,4 (IC95 2,1–9,2 2192 1 9 cefepima 26 2, 1,3–5,1. 1351 1,3–5,1 1,3–5,1) antineoplásicos 27 1,2–6,2, 1262 1,2–6,2 , 1,2–6,2) 904 04 9,0 1,942,3, 19423 1,9 42,3 42 1,9-42,3) 167 16 16, 2,1–134,9 211349 134 897 97 8,9 1,9–42,9. 19429 1,9–42,9 1,9–42,9) Conclusões associouse associou se meses 2016201 201 2016–201 52, n=4 (n= 6,3 n=6 4,8 p0 p=0, IC9 [IC95 2,3–12, 2312 44 4, (IC9 2,1–9, 219 135 1,3–5, 126 1,2–6, 90 9, 942 1,942,3 1942 19 1, 423 42, 1,9-42,3 2,1–134, 21134 13 89 8, 1,9–42, 201620 20 2016–20 n= (n 6, p=0 [IC9 2,3–12 231 (IC 2,1–9 21 1,3–5 1,2–6 94 1,942, 194 1,9-42, 2,1–134 2113 1,9–42 20162 2016–2 p= [IC 2,3–1 23 2,1– 1,3– 1,2– 1,942 1,9-42 2,1–13 211 1,9–4 2016– 2,3– 2,1 1,3 1,2 1,94 1,9-4 2,1–1 1,9– 2,3 1,9-

The Digital Image Correlation (DIC) technique is an important method of evaluating material strain fields. Composite materials have inherently heterogeneous elastic properties, in the function of the different phases present in the composition, whereat the traditional techniques of deformation evaluation may not be sufficient to determine the mechanisms that eventually contribute to the failure of the material. The present work were evaluated, the tensile mechanical properties of polyester matrix composites loaded with an industrial residue of red mud, with a mass fraction of 20%. The properties were surveyed using the conventional technique of strain gauge and compared with the data obtained through DIC. The results showed that the DIC technique was accurate in monitoring the displacements and determining the average deformation of the tested specimens, in addition to providing ample deformation fields, for the evaluation of failure mechanisms throughout the sample request process. (DIC fields composition evaluated mud 20 20% specimens process 2

ABSTRACT BACKGROUND: Asthma is a chronic airway disease that affects 339 million people worldwide. It is a heterogeneous disease with different risks, including in family environments, where intimate partner violence occurs. OBJECTIVE: This study aimed to investigate the possible association between psychosocial factors and asthma control in adults exposed to intimate partner violence. DESIGN AND SETTING: This cross-sectional study was conducted at a Brazilian public higher education institution in Salvador, Bahia, Brazil. METHODS: The study population consisted of adults clinically diagnosed with severe asthma and those with mild/moderate asthma identified at an asthma referral outpatient clinic. The sample comprised 492 participants who underwent clinical evaluation and completed questionnaires to assess asthma control, depression, stress, and resilience. The Conflict Tactics Scale, which measures tactics for managing marital conflicts, was used to estimate the level of intimate partner violence. RESULTS: Of the 492 participants, 76.2% were women and 91% self-referenced color black/brown, 37.8% reported low family income, 87.4% reported low education level, 71.7% reported high stress, 32.5% reported low resilience, 18.5% reported moderate or severe depression, 83.3% reported resolute negotiation, 49.4% reported major psychological aggression, 19.6% reported major physical aggression, 15.5% reported major injury, and 7.3% reported major sexual coercion. Regression analysis revealed that sex was an effect modifier. CONCLUSION: Women in situations of social vulnerability, with low income and poor education, with depression, severe asthma, and those who used aggression to resolve marital conflicts had a profile associated with a lack of asthma control. BACKGROUND 33 worldwide risks environments occurs OBJECTIVE SETTING crosssectional cross sectional Salvador Bahia Brazil METHODS mildmoderate mild clinic 49 depression stress resilience Scale RESULTS 762 76 2 76.2 91 selfreferenced self referenced blackbrown black brown black/brown 378 37 8 37.8 874 87 4 87.4 717 71 7 71.7 325 32 5 32.5 185 18 18.5 833 83 3 83.3 negotiation 494 49.4 196 19 6 19.6 155 15 15.5 injury 73 7.3 coercion modifier CONCLUSION vulnerability 76. 9 37. 87. 71. 32. 1 18. 83. 49. 19. 15. 7.

ABSTRACT Obesity, a complex disease that involves energy imbalance and chronic low-grade inflammation, is implicated in the pathogenesis of several chronic non-communicable diseases. As dietary components modulate the human body's inflammatory status, the Dietary Inflammatory Index (DII®), a literature-derived dietary index, was developed in 2009 to characterize the inflammatory potential of a habitual diet. Abundant research has been conducted to investigate the associations between DII and obesity. In this narrative review, we examined the current state of the science regarding the relationships between DII and the inflammatory pathophysiological aspects related to obesity. DII is associated with inflammation in obesity. The most pro-inflammatory diet was directly related to higher levels of pro-inflammatory markers, which included C-reactive protein (CRP), interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α). Therefore, evidence suggests that the use of the DII may be useful for understanding the relationship between diet and the inflammatory process related to obesity. Obesity lowgrade low grade noncommunicable non communicable diseases bodys body s status DII®, DII® , (DII®) literaturederived literature derived index 200 obesity review proinflammatory pro markers Creactive C reactive CRP, CRP (CRP) interleukin6 interleukin 6 interleukin- IL6, IL6 IL (IL-6) IL1β, IL1β ILβ 1β, 1β β IL-1β factorα factor α TNFα. TNFα TNF . (TNF-α) Therefore (DII® 20 (CRP (IL-6 (TNF-α (DII 2 (IL- (IL

Abstract Physical Insufficient levels of physical activity and sedentary behavior are highly prevalent worldwide and associated with cardiometabolic diseases and may vary according to gender and academic training. The objective was to investigate the association of sex and academic training with the level of physical activity and time spent in sedentary behavior in nursing students. It is a cross-sectional study with 286 nursing students from a public university. A sociodemographic and academic characterization instrument and an extended version of the International Physical Activity Questionnaire were applied. Data were analyzed descriptively and by Pearson's Chi-Square/Fisher's Exact test. The significance level was 5%. 65.7% of university students were active. Men were more active in leisure (p=0.000) and commuting (p=0.03). There was no association between sex and semester and total physical activity level. The prevalence of time in sedentary behavior ≥ 8 h/day for seven, five days, and weekends were 39.3%, 57.1%, and 21.4% for men and 55.0%, 65.1%, and 43.0% for women. A more significant proportion of women showed time in sedentary behavior ≥ 8 h/day on weekends (p=0.015) than men. A higher proportion between the 1st and 5th semesters remained ≥ 8 h/day in sedentary behavior on seven (p=0.024) and five days (p=0.001) week compared to those between the 6th and 10th semesters. The prevalence of insufficient physical activity levels and a long time in sedentary behavior were high and influenced by gender and training phase. Men were more active in commuting and leisure than women. Sedentary behavior is associated with gender and a training phase. crosssectional cross sectional 28 applied Pearsons Pearson s ChiSquare/Fishers ChiSquareFishers Chi Square/Fisher Square Fisher test 5 5% 657 65 7 65.7 p=0.000 p0000 p 0 000 (p=0.000 p=0.03. p003 p=0.03 . 03 (p=0.03) hday h day 393 39 3 39.3% 571 57 1 57.1% 214 21 4 21.4 550 55 55.0% 651 65.1% 430 43 43.0 p=0.015 p0015 015 (p=0.015 st th p=0.024 p0024 024 (p=0.024 p=0.001 p0001 001 (p=0.001 phase 2 ChiSquare Fishers SquareFisher 6 65. p=0.00 p000 00 (p=0.00 p00 p=0.0 (p=0.03 39.3 57.1 21. 55.0 65.1 43. p=0.01 p001 01 (p=0.01 p=0.02 p002 02 (p=0.02 (p=0.0 p0 p=0. 39. 57. 55. (p=0. p=0 (p=0 p= (p= (p

Resumo Nível insuficiente de atividade física e comportamento sedentário estão associados a doenças cardiometabólicas e apresentam prevalências elevadas mundialmente e podem variar entre sexo e fase de formação de universitários (as) em enfermagem. Objetivou-se investigar a associação do sexo e da fase de formação acadêmica com o nível de atividade física e tempo em comportamento sedentário em universitários de enfermagem. Estudo transversal, com 286 universitários de enfermagem de uma Universidade pública. Aplicou-se instrumento de caracterização sociodemográfica, acadêmica e versão longa do Questionário Internacional de Atividade Física, analisados descritivamente e pelo teste Qui-Quadrado de Pearson/Exato de Fisher. O nível de significância foi de 5%. 65,7% dos universitários eram ativos. Homens foram mais ativos no lazer (p=0,000) e deslocamento (p=0,03). Não houve associação do sexo e do semestre com nível de atividade física total. As prevalências do tempo em comportamento sedentário ≥ 8 h/dia, durante sete, cinco dias e final de semana foram, respectivamente, 39,3%, 57,1% e 21,4% para homens e 55,0%, 65,1% e 43,0% para mulheres. Maior proporção de mulheres apresentou tempo em comportamento sedentário ≥ 8 h/dia no final de semana (p=0,015). Maior proporção entre o 1º e 5º semestres permaneciam ≥ 8 h/dia em comportamento sedentário em sete (p=0.024) e cinco dias (p=0.001) na semana comparados àqueles entre o 6º e 10º semestre. As prevalências do nível insuficiente de atividade física e tempo elevado em comportamento sedentário foram altas. Homens foram mais ativos no deslocamento e no lazer do que as mulheres. Comportamento sedentário se associou ao gênero e a fase de formação. (as Objetivouse Objetivou transversal 28 pública Aplicouse Aplicou sociodemográfica Física QuiQuadrado Qui Quadrado PearsonExato Pearson Exato Fisher 5 5% 657 65 7 65,7 p=0,000 p0000 p 0 000 (p=0,000 p=0,03. p003 p=0,03 . 03 (p=0,03) total hdia h dia respectivamente 393 39 3 39,3% 571 57 1 57,1 214 21 4 21,4 550 55 55,0% 651 65,1 430 43 43,0 p=0,015. p0015 p=0,015 015 (p=0,015) º p=0.024 p0024 024 (p=0.024 p=0.001 p0001 001 (p=0.001 altas 2 6 65, p=0,00 p000 00 (p=0,00 p00 p=0,0 (p=0,03 39,3 57, 21, 55,0 43, p001 p=0,01 01 (p=0,015 p=0.02 p002 02 (p=0.02 p=0.00 (p=0.00 (p=0,0 p0 p=0, 39, 55, (p=0,01 p=0.0 (p=0.0 (p=0, p=0 p=0. (p=0. (p=0 p= (p= (p

Resumen Las estrategias de marketing evolucionan con nuevos modelos de comunicación liderados por las plataformas digitales en una sociedad cada vez más conectada. Actualmente, las empresas buscan relacionarse con sus clientes basándose en la lógica emocional y el reconocimiento de las marcas, superando únicamente los aspectos racionales vinculados a los productos y servicios. A raíz de investigaciones vinculadas a cambios en las tácticas de marketing, este artículo abordará el concepto y las aplicaciones del Marketing 4.0 a partir del modelo de negocio liderado por la empresa TAG - Experiências Literárias. En este sentido, el estudio analizó los canales digitales oficiales de la compañía, con énfasis en Facebook, Instagram y las aplicaciones móviles, a partir del análisis de contenido. Se concluye que la empresa está enfocada en nuevos paradigmas de relación con el cliente, creando formas de identificarse con su público objetivo como esencia de sus servicios, a partir de los nuevos desafíos que propone el Marketing 4.0. conectada Actualmente marcas servicios 40 4 0 4. Literárias sentido compañía Facebook móviles contenido cliente

Abstract Marketing strategies evolve alongside new communication models led by digital platforms in an increasingly connected society. Currently, companies seek to relate to their customers based on emotional logic and recognition in relation to brands, surpassing only the rational aspects linked to products and services. In the wake of investigations linked to changes in marketing tactics, this article will address the concept and applications of Marketing 4.0 based on the business model led by the company TAG - Literary Experiences. To this end, the study analyzed the company’s official digital channels, with an emphasis on Facebook, Instagram, and mobile applications, based on content analysis. It is concluded that the company is focused on new customer relationship paradigms, creating ways of identifying with its target audience as the essence of its services, based on the new challenges proposed by Marketing 4.0. society Currently brands services tactics 40 4 0 4. Experiences end companys s channels Facebook Instagram analysis paradigms

Resumo As estratégias de marketing evoluem em conjunto com os novos modelos de comunicação protagonizados pelas plataformas digitais, em uma sociedade cada vez mais conectada. Atualmente, as empresas buscam se relacionar com seus clientes em lógicas emocionais e de reconhecimento em relação a marcas, superando somente os aspectos racionais ligados a produtos e serviços. Na esteira das investigações ligadas às mudanças das táticas mercadológicas, esse artigo abordará o conceito e as aplicações do Marketing 4.0 a partir do modelo de negócios protagonizado pela empresa TAG - Experiências Literárias. Para isso, o estudo analisou os canais oficiais digitais da empresa, com ênfase no Facebook, Instagram e os aplicativos mobile, a partir da análise de conteúdo. Conclui-se que a empresa está focada nos novos paradigmas de relacionamento do cliente, criando formas de identificação com o seu público-alvo como essência dos seus serviços, a partir dos novos desafios propostos pelo Marketing 4.0. conectada Atualmente marcas serviços mercadológicas 40 4 0 4. Literárias isso Facebook mobile conteúdo Concluise Conclui cliente públicoalvo público alvo

Resumo Fundamento vários estudos avaliam alterações ecocardiográficas como preditores de risco cardiovascular; entretanto, nenhum associa risco cardiovascular global com alterações ecocardiográficas em brasileiros. Objetivo Este estudo avalia a associação entre risco cardiovascular global (ASCVD) e achados ecocardiográficos como hipertrofia ventricular esquerda (HVE), disfunção diastólica (DDVE) e aumento do volume do átrio esquerdo (AE). Métodos A população foi composta por participantes do ELSA-Brasil que realizaram ecocardiografia entre 2008 e 2010 (n = 2.973). Eram assintomáticos e não tinham história de doença cardiovascular (DCV). O escore ASCVD foi calculado em dois períodos: 2008-2010 e 2012-2014. Razões de prevalência (RP) foram estimadas com intervalos de confiança (IC) de 95%. Resultados Evidenciou-se associação entre alterações ecocardiográficas e alto risco cardiovascular global (escore ASCVD ≥ 7,5) nos dois períodos do estudo, separadamente. O risco global combinado (baixo risco no primeiro período e alto risco no segundo período) teve associação significativa apenas com DDVE (RP = 3,68; IC 95%: 2,63-5,15) e HVE (RP = 2,20; IC 95%: 1,62–3,00). Conclusão Alterações ecocardiográficas (DDVE, HVE e aumento do volume do AE) são preditores independentes de risco cardiovascular em adultos brasileiros sem DCV prévias.

Abstract Background Several studies have evaluated echocardiographic abnormalities as predictors of cardiovascular risk; however, none have associated the global cardiovascular risk with echocardiographic abnormalities in the Brazilian population. Objective This study evaluates the association between the global cardiovascular risk (ASCVD score) and three echocardiographic abnormalities: left ventricular hypertrophy (LVH), left ventricular diastolic dysfunction (LVDD), and increased left atrium (LA) volume. Methods The study population was composed of participants from ELSA-Brasil who underwent echocardiography between 2008 and 2010 (n = 2973). They were asymptomatic and had no history of cardiovascular disease. The ASCVD score was calculated in two periods: 2008-2010 and 2012-2014. Prevalence ratios (PR) were estimated with 95% confidence intervals (CI). Results There is an association between echocardiographic abnormalities and high global cardiovascular risk (ASCVD score ≥ 7.5) in both study periods, separately. The combined global risk (low risk in the first period and high risk in the second period) was significantly associated only with LVDD (PR = 3.68, CI 95% 2.63–5.15) and LVH (PR = 2.20, 95% CI 1.62–3.00). Conclusion Echocardiographic abnormalities (LVDD, LVH, and increased LA volume) are independent predictors of cardiovascular risk in Brazilian adults.

Resumo No Brasil, as políticas sobre drogas passaram por modificações ao longo do tempo, carregando marcas de cada período histórico e interesse sanitário-político. Na atual conjuntura, por exemplo, há uma tendência de oposição aos ideais do movimento de reforma psiquiátrica. Nesse contexto, este artigo objetiva analisar os elementos-chave evidenciados a partir do estudo de um documento normativo sobre drogas, na perspectiva da análise de discurso crítica. Realizou-se a análise da Lei no 13.840, de 2019, conforme o modelo tridimensional de Fairclough, com discussão a partir dos conceitos de biopoder e biopolítica de Foucault. A ênfase no tratamento pautado pela internação involuntária, comunidade terapêutica e abstinência reproduz uma perspectiva asilar de tratamento. Observa-se, assim, a reprodução de concepções asilar, proibicionista e autoritária, justificadas sob um véu de neutralidade ideológica e evidências científicas, que corroboram a existência de um movimento antirreformista.

Abstract Brazilian drug policies have undergone changes over time, bearing marks for each historical period and experienced sanitary-political interests. Nowadays, an anti-reformist character was perceived in changes concentrated on Law no. 13,840, of June 5, 2019. The aim of this study is to analyze the key elements of a normative document on drugs based on the Critical Discourse Analysis. We analyzed the Law no. 13,840 using Fairclough’s method for three-dimensional analysis and then discussed it with Foucault’s notions of Biopower and Biopolitics. We consider that the emphasis on involuntary hospitalization, therapeutic communities and abstinence opposes the Brazilian psychiatric reform movement. The development of oppressive care practices are hidden by the so-called ideological neutrality and scientific evidence.