RESUMEN Introducción: Las pérdidas cognitivas se encuentran entre los eventos más prevalentes en la población anciana y pueden causar déficits funcionales. Entre las alternativas de prevención y tratamiento no farmacológico disponibles, el aumento de los niveles de condición física funcional se presenta como una estrategia importante que sugiere mejoras en la función física y cognitiva de los ancianos, desencadenada por la práctica de ejercicios. Objetivo: Determinar el poder predictivo de los indicadores de aptitud funcional y establecer sus puntos de corte como discriminadores del deterioro cognitivo en adultos mayores. Métodos: La muestra estuvo compuesta por 310 ancianos que respondieron un cuestionario que comprendía información sociodemográfica, hábitos de vida, hospitalización en los últimos 12 meses, presencia de comorbilidad y el Mini-Examen del Estado Mental. La condición física funcional se evaluó utilizando la fuerza de agarre manual (FAM) y las pruebas de sentarse y levantarse de una silla. Para identificar predictores de deterioro cognitivo, se adoptó el análisis de curvas Receiver Operating Characteristic (ROC), con intervalo de confianza del 95% (IC95%). Posteriormente se identificaron los puntos de corte con sus respectivas sensibilidades y especificidades. Los análisis se realizaron respetando el nivel de significancia del 5%. Resultados: Se observó que algunos indicadores de aptitud funcional mostraron un Área Bajo la Curva (ABC) significativa, y la prueba de sentarse y pararse (ABC=0,72; 95%IC: 0,64-0,77) mostró los mejores resultados. Los mejores puntos de corte para el test FAM y el sit-and-stand test fueron 18,8 kgf y 8 repeticiones, respectivamente. Conclusión: Los resultados del presente estudio permiten concluir que el test sit-to-stand es moderadamente eficiente para discriminar la presencia de deterioro cognitivo en adultos mayores. Nivel de Evidencia III; Estudio Transversal. Introducción funcionales disponibles ejercicios Objetivo mayores Métodos 31 sociodemográfica vida 1 meses MiniExamen Mini Examen Mental (FAM silla ROC, ROC , (ROC) 95 IC95%. IC95 IC IC95% . (IC95%) especificidades 5 5% Resultados ABC (ABC significativa ABC=0,72 ABC072 0 72 (ABC=0,72 95%IC 95IC 0,640,77 064077 0,64 0,77 64 77 0,64-0,77 sitandstand sit and stand 188 18 18, repeticiones respectivamente Conclusión sittostand to III Transversal 3 (ROC 9 IC9 (IC95% ABC=0,7 ABC07 7 (ABC=0,7 640 0,640,7 06407 064 0,6 077 0,7 6 0,64-0,7 (IC95 ABC=0, ABC0 (ABC=0, 0,640, 0640 06 0, 07 0,64-0, (IC9 ABC=0 (ABC=0 0,640 0,64-0 (IC ABC= (ABC= 0,64-

ABSTRACT Introduction: Cognitive losses are among the most prevalent events in the elderly population and can cause functional deficits. Among the available non-drug prevention and treatment alternatives, the increase in functional fitness levels is presented as an important strategy suggesting improvements in the physical and cognitive function of the elderly triggered by exercise. Objective: To determine the predictive power of functional fitness indicators and establish their cutoff points as discriminators of cognitive impairment in the elderly. Methods: The sample comprised 310 elderly people who answered a questionnaire comprising sociodemographic information, lifestyle habits, hospitalization in the last 12 months, presence of comorbidity, and the Mini-Mental State Examination. Functional fitness was assessed using the Hand Grip Strength (HGS) and sitting and rising from a chair tests. To identify predictors of cognitive impairment, analysis of Receiver Operating Characteristic (ROC) curves was adopted, with a confidence interval of 95% (95%CI). Subsequently, the cut-off points with their respective sensitivities and specificities were identified. The analyses were performed respecting the significance level of 5%. Results: It was observed that some functional fitness indicators showed significant Area Under the Curve (AUC), and the sit-and-stand test (AUC=0.72; 95%CI: 0.64-0.77) showed the best results. The best cut-off points for the HGS and sit-and-stand tests were 18,8 kgf and eight repetitions, respectively. Conclusion: The results of the present study allow us to conclude that the sit-to-stand test is moderately efficient in discriminating the presence of cognitive impairment in the elderly. Level of Evidence III; Study Cross-sectional. Introduction deficits nondrug non drug alternatives exercise Objective Methods 31 information habits 1 months comorbidity MiniMental Mini Mental Examination (HGS ROC (ROC adopted 95 95%CI. 95CI CI 95%CI . (95%CI) Subsequently cut off identified 5 5% Results AUC, AUC , (AUC) sitandstand sit stand AUC=0.72 AUC072 0 72 (AUC=0.72 0.640.77 064077 0.64 0.77 64 77 0.64-0.77 188 18 8 18, repetitions respectively Conclusion sittostand III Crosssectional. Crosssectional Cross sectional. sectional Cross-sectional 3 9 (95%CI (AUC AUC=0.7 AUC07 7 (AUC=0.7 640 0.640.7 06407 064 0.6 077 0.7 6 0.64-0.7 AUC=0. AUC0 (AUC=0. 0.640. 0640 06 0. 07 0.64-0. AUC=0 (AUC=0 0.640 0.64-0 AUC= (AUC= 0.64-

RESUMO Introdução: As perdas cognitivas estão entre os eventos mais prevalentes na população idosa, podendo causar déficits funcionais. Dentre as alternativas de prevenção e tratamento não medicamentosos disponíveis, o aumento dos níveis de aptidão funcional apresenta-se como uma estratégia importante sugerindo melhorias na função física e na função cognitiva de idosos, desencadeadas através da prática de exercícios. Objetivo: Determinar o poder preditivo dos indicadores de aptidão funcional e estabelecer seus pontos de corte como discriminadores do comprometimento cognitivo em idosos. Métodos: A amostra compreendeu 310 idosos que responderam a um questionário composto por informações sociodemográficas, hábitos de vida, hospitalização nos últimos 12 meses, presença de comorbidade e o Mini-Exame do Estado Mental. A aptidão funcional foi avaliada por meio dos testes de Força de Preensão Manual (FPM) e o de sentar e levantar da cadeira. Para identificação dos preditores do comprometimento cognitivo, foi adotada a análise das curvas Receiver Operating Characteristic (ROC), com intervalo de confiança de 95% (IC95%). Posteriormente, identificaram-se os pontos de corte com as respectivas sensibilidades e especificidades. As análises foram efetuadas respeitando-se o nível de significância de 5%. Resultados: Observou-se que alguns indicadores de aptidão funcional apresentaram Área Sob a Curva (ASC) significativas, sendo que o teste de sentar e levantar da cadeira (ASC=0,72; IC95%= 0,64-0,77) apresentou os melhores resultados. Os melhores pontos de corte para o teste de FPM e o teste de sentar e levantar da cadeira foram de 18,8 kgf e 8 repetições respectivamente. Conclusão: Os resultados do presente estudo permitem concluir que o teste de sentar e levantar da cadeira apresenta moderada eficiência para discriminar a presença de comprometimento cognitivo em idosos. Nível de Evidência III; Estudo Transversal. Introdução idosa funcionais disponíveis apresentase se exercícios Objetivo Métodos 31 sociodemográficas vida 1 meses MiniExame Mini Exame Mental (FPM ROC, ROC , (ROC) 95 IC95%. IC95 IC IC95% . (IC95%) Posteriormente identificaramse identificaram especificidades respeitandose respeitando 5 5% Resultados Observouse Observou ASC (ASC significativas ASC=0,72 ASC072 0 72 (ASC=0,72 0,640,77 064077 0,64 0,77 64 77 0,64-0,77 188 18 18, respectivamente Conclusão III Transversal 3 (ROC 9 IC9 (IC95% ASC=0,7 ASC07 7 (ASC=0,7 640 0,640,7 06407 064 0,6 077 0,7 6 0,64-0,7 (IC95 ASC=0, ASC0 (ASC=0, 0,640, 0640 06 0, 07 0,64-0, (IC9 ASC=0 (ASC=0 0,640 0,64-0 (IC ASC= (ASC= 0,64-

Resumen Objetivo Evaluar los factores asociados al aumento de peso interdialítico en usuarios de servicios de hemodiálisis en una región metropolitana de Brasil. Métodos Estudio epidemiológico transversal que incluyó 1.024 individuos con enfermedad renal crónica en hemodiálisis en Brasil. El aumento de peso interdialítico se evaluó mediante el porcentaje de aumento de peso entre una sesión de hemodiálisis y otra. Las variables incluidas en el análisis de regresión logística binaria fueron seleccionadas considerando p< 0,10 en la prueba bivariada. Resultados Se demostró que tener más años de estudio (OR=0,537;IC 95 % = 0,310–0,931; p=0,027) y sobrepeso (OR=0,661;IC 95 % = 0,461–0,948; p=0,024) u obesidad ( OR=0,387;IC 95 % = 0,246–0,608; p=<0,001) redujo las chances de que los usuarios presenten un elevado aumento de peso interdialítico. Usuarios sin trabajo remunerado (OR=2,025; IC 95 % = 1,218–3,365; p=0,007) y que no adoptaban medidas para reducir la sal (OR=1,694; IC 95 % = 1,085–2,645; p=0,020) tuvieron más chances de aumento de peso interdialítico. Conclusión Los resultados señalan una relación entre el aumento de peso interdialítico y la ausencia de trabajo remunerado y la no adopción de medidas para reducir la ingesta de sal en la dieta. Por lo tanto, el conocimiento sobre estos factores asociados puede ser una alternativa importante para la orientación individualizada de esta población. Brasil 1024 1 024 1.02 otra p 010 0 10 0,1 bivariada OR=0,537IC OR0537IC ORIC OR=0,537 OR 537 9 0,310–0,931 03100931 310 931 p=0,027 p0027 027 OR=0,661IC OR0661IC OR=0,661 661 0,461–0,948 04610948 461 948 p=0,024 p0024 OR=0,387IC OR0387IC OR=0,387 387 0,246–0,608 02460608 246 608 p=<0,001 p0001 001 OR=2,025 OR2025 2 025 (OR=2,025 1,218–3,365 12183365 218 3 365 p=0,007 p0007 007 OR=1,694 OR1694 694 (OR=1,694 1,085–2,645 10852645 085 645 p=0,020 p0020 020 dieta tanto población 102 02 1.0 01 0, 537IC OR0537 OR=0,53 53 0,310–0,93 0310093 31 93 p=0,02 p002 661IC OR0661 OR=0,66 66 0,461–0,94 0461094 46 94 387IC OR0387 OR=0,38 38 0,246–0,60 0246060 24 60 p=<0,00 p000 00 OR=2,02 OR202 (OR=2,02 1,218–3,36 1218336 21 36 p=0,00 OR=1,69 OR169 69 (OR=1,69 1,085–2,64 1085264 08 64 1. OR053 OR=0,5 5 0,310–0,9 031009 p=0,0 p00 OR066 OR=0,6 6 0,461–0,9 046109 4 OR038 OR=0,3 0,246–0,6 024606 p=<0,0 OR=2,0 OR20 (OR=2,0 1,218–3,3 121833 OR=1,6 OR16 (OR=1,6 1,085–2,6 108526 OR05 OR=0, 0,310–0, 03100 p=0, p0 OR06 0,461–0, 04610 OR03 0,246–0, 02460 p=<0, OR=2, OR2 (OR=2, 1,218–3, 12183 OR=1, OR1 (OR=1, 1,085–2, 10852 OR0 OR=0 0,310–0 0310 p=0 0,461–0 0461 0,246–0 0246 p=<0 OR=2 (OR=2 1,218–3 1218 OR=1 (OR=1 1,085–2 1085 OR= 0,310– 031 p= 0,461– 046 0,246– p=< (OR= 1,218– 121 1,085– 108 0,310 03 0,461 04 0,246 (OR 1,218 12 1,085 0,31 0,46 0,24 1,21 1,08 0,3 0,4 0,2 1,2 1,0 1,

Abstract Objectives The study aimed to evaluate the factors associated with interdialytic weight gain in users of haemodialysis services in a metropolitan region of Brazil. Methods This is an cross-sectional epidemiological study with 1,024 individuals with chronic kidney disease on haemodialysis in Brazil. Interdialytic weight gain was evaluated by the percentage weight gain between one haemodialysis session and another. The variables included in the binary logistic regression analysis were selected by considering p< 0.10 in the bivariate test. Results We demonstrated that having more years of study (OR=0.537;CI 95% = 0.310–0.931; p=0.027) and be overweight (OR=0.661;CI 95% = 0.461–0.948; p=0.024) or obese (OR=0.387;CI 95% = 0.246–0.608; p=<0.001) reduced the chances of users having high interdialytic weight gain. Those who did not have paid work (OR=2.025;CI 95% = 1.218–3.365; p=0.007) and not adopting measures to reduce salt increased (OR=1.694;CI 95% = 1.085–2.645; p=0.020) increased the chances of interdialytic weight. Conclusion The results point to an association between the increase in interdialytic weight gain and the absence of paid work and the non-adoption of measures to reduce salt intake in the diet. Therefore, the need for knowledge about these associated factors can be an important alternative for the individual targeting of this population. Brazil crosssectional cross sectional 1024 1 024 1,02 another p 010 0 10 0.1 test OR=0.537CI OR0537CI ORCI OR=0.537 CI OR 537 95 0.310–0.931 03100931 310 931 p=0.027 p0027 027 OR=0.661CI OR0661CI OR=0.661 661 0.461–0.948 04610948 461 948 p=0.024 p0024 OR=0.387CI OR0387CI OR=0.387 387 0.246–0.608 02460608 246 608 p=<0.001 p0001 001 OR=2.025CI OR2025CI OR=2.025 2 025 1.218–3.365 12183365 218 3 365 p=0.007 p0007 007 OR=1.694CI OR1694CI OR=1.694 694 1.085–2.645 10852645 085 645 p=0.020 p0020 020 nonadoption non adoption diet Therefore population 102 02 1,0 01 0. 537CI OR0537 OR=0.53 53 9 0.310–0.93 0310093 31 93 p=0.02 p002 661CI OR0661 OR=0.66 66 0.461–0.94 0461094 46 94 387CI OR0387 OR=0.38 38 0.246–0.60 0246060 24 60 p=<0.00 p000 00 025CI OR2025 OR=2.02 1.218–3.36 1218336 21 36 p=0.00 694CI OR1694 OR=1.69 69 1.085–2.64 1085264 08 64 1, OR053 OR=0.5 5 0.310–0.9 031009 p=0.0 p00 OR066 OR=0.6 6 0.461–0.9 046109 4 OR038 OR=0.3 0.246–0.6 024606 p=<0.0 OR202 OR=2.0 1.218–3.3 121833 OR169 OR=1.6 1.085–2.6 108526 OR05 OR=0. 0.310–0. 03100 p=0. p0 OR06 0.461–0. 04610 OR03 0.246–0. 02460 p=<0. OR20 OR=2. 1.218–3. 12183 OR16 OR=1. 1.085–2. 10852 OR0 OR=0 0.310–0 0310 p=0 0.461–0 0461 0.246–0 0246 p=<0 OR2 OR=2 1.218–3 1218 OR1 OR=1 1.085–2 1085 OR= 0.310– 031 p= 0.461– 046 0.246– p=< 1.218– 121 1.085– 108 0.310 03 0.461 04 0.246 1.218 12 1.085 0.31 0.46 0.24 1.21 1.08 0.3 0.4 0.2 1.2 1.0 1.

Resumo Objetivo Avaliar os fatores associados ao ganho de peso interdialítico em usuários de serviços de hemodiálise em uma Região Metropolitana do Brasil. Métodos Estudo epidemiológico transversal envolvendo 1.024 indivíduos com doença renal crônica em hemodiálise no Brasil. O ganho de peso interdialítico foi avaliado pelo percentual de ganho de peso entre uma sessão de hemodiálise e outra. As variáveis incluídas na análise de regressão logística binária foram selecionadas considerando p< 0,10 no teste bivariado. Resultados Demonstramos que ter mais anos de estudo (OR=0,537;IC 95% = 0,310–0,931; p=0,027) e sobrepeso (OR=0,661;IC 95% = 0,461–0,948; p=0,024) ou obesidade ( OR=0,387;IC 95% = 0,246–0,608; p=<0,001) reduziu as chances de os usuários apresentarem alto ganho de peso interdialítico. Usuários sem trabalho remunerado (OR=2,025; IC 95% = 1,218–3,365; p=0,007) e que não adotavam medidas para reduzir o sal (OR=1,694; IC 95% = 1,085–2,645; p=0,020) tiveram maiores chances de ganho de peso interdialítico. Conclusão Os resultados apontam para associação entre o aumento do ganho de peso interdialítico e a ausência de trabalho remunerado e a não adoção de medidas para reduzir a ingestão de sal na dieta. Portanto, o conhecimento sobre esses fatores associados pode ser uma alternativa importante para o direcionamento individualizado dessa população. Brasil 1024 1 024 1.02 outra p 010 0 10 0,1 bivariado OR=0,537IC OR0537IC ORIC OR=0,537 OR 537 95 0,310–0,931 03100931 310 931 p=0,027 p0027 027 OR=0,661IC OR0661IC OR=0,661 661 0,461–0,948 04610948 461 948 p=0,024 p0024 OR=0,387IC OR0387IC OR=0,387 387 0,246–0,608 02460608 246 608 p=<0,001 p0001 001 OR=2,025 OR2025 2 025 (OR=2,025 1,218–3,365 12183365 218 3 365 p=0,007 p0007 007 OR=1,694 OR1694 694 (OR=1,694 1,085–2,645 10852645 085 645 p=0,020 p0020 020 dieta Portanto população 102 02 1.0 01 0, 537IC OR0537 OR=0,53 53 9 0,310–0,93 0310093 31 93 p=0,02 p002 661IC OR0661 OR=0,66 66 0,461–0,94 0461094 46 94 387IC OR0387 OR=0,38 38 0,246–0,60 0246060 24 60 p=<0,00 p000 00 OR=2,02 OR202 (OR=2,02 1,218–3,36 1218336 21 36 p=0,00 OR=1,69 OR169 69 (OR=1,69 1,085–2,64 1085264 08 64 1. OR053 OR=0,5 5 0,310–0,9 031009 p=0,0 p00 OR066 OR=0,6 6 0,461–0,9 046109 4 OR038 OR=0,3 0,246–0,6 024606 p=<0,0 OR=2,0 OR20 (OR=2,0 1,218–3,3 121833 OR=1,6 OR16 (OR=1,6 1,085–2,6 108526 OR05 OR=0, 0,310–0, 03100 p=0, p0 OR06 0,461–0, 04610 OR03 0,246–0, 02460 p=<0, OR=2, OR2 (OR=2, 1,218–3, 12183 OR=1, OR1 (OR=1, 1,085–2, 10852 OR0 OR=0 0,310–0 0310 p=0 0,461–0 0461 0,246–0 0246 p=<0 OR=2 (OR=2 1,218–3 1218 OR=1 (OR=1 1,085–2 1085 OR= 0,310– 031 p= 0,461– 046 0,246– p=< (OR= 1,218– 121 1,085– 108 0,310 03 0,461 04 0,246 (OR 1,218 12 1,085 0,31 0,46 0,24 1,21 1,08 0,3 0,4 0,2 1,2 1,0 1,

Resumen Objetivo Identificar los factores que facilitan o dificultan la construcción de la autonomía en la adolescencia a través de la experiencia de jóvenes adultos con diabetes tipo 1 y sus padres. Métodos: Estudio de naturaleza cualitativa, descriptiva y exploratoria. Se realizaron dos entrevistas de grupo focal, una con nueve jóvenes adultos expertos en la gestión de su enfermedad y otra con siete padres. Para el análisis de datos se utilizó el análisis de contenido temático y categorial, con particularidades de entrevista de grupo focal y recurso del software NVIVO 12. Resultados Surgieron dos grandes categorías y diez subcategorías relativas a los factores que facilitaron el desarrollo de la autonomía en la gestión de la enfermedad (sistemas de apoyo, conocimientos, alimentación, bomba de insulina, responsabilización temprana de la gestión de la terapéutica, características de los jóvenes) y los que la dificultaron (régimen terapéutico, estigma, actitudes de los profesionales de la salud, características de los jóvenes, conocimientos). Conclusión La autonomía en la gestión de la diabetes incluye muchos desafíos para los adolescentes, lo que requiere adaptación de actitudes e intervenciones de profesionales. Además de la gestión tradicional del estado de salud, es esencial abordar temas relacionados con la socialización de los adolescentes y buscar estrategias innovadoras que promuevan el coping y la calidad de vida. Los resultados de este estudio permiten reflexionar sobre la relación terapéutica con los adolescentes y destacar la importancia de individualizar los cuidados y las respuestas innovadoras para sus necesidades específicas. padres Métodos cualitativa exploratoria categorial 12 sistemas apoyo conocimientos alimentación insulina régimen terapéutico estigma salud conocimientos. . conocimientos) vida específicas

Abstract Objective To identify the factors that facilitate or hinder the construction of autonomy in adolescence through the experience of young adults with type-1 diabetes and their parents. Methods This was a qualitative, descriptive, and exploratory study. Two focus group interviews were conducted: one with nine young adults who were experts in managing their illness and the other with seven parents. Thematic and categorical content analysis was used for data analysis, with particularities of a focus group interview and the use of the NVIVO 12 software. Results Two major categories and ten subcategories related to factors that facilitated (support systems, knowledge, diet, insulin pump, early responsibility for managing therapy, and characteristics of young people) and hindered (therapeutic regimen, stigma, attitude of health professionals, characteristics of young people, and knowledge) the development of autonomy in disease management emerged. Conclusion Autonomy in the management of diabetes involves several challenges for adolescents, which requires adaptation of attitudes and interventions by professionals. In addition to the traditional management of the health condition, addressing issues related to the socialization of adolescents is essential, looking for innovative strategies that promote coping and quality of life. The results of this study make it possible to reflect on the therapeutic relationship with adolescents, emphasizing the importance of individualizing care and innovative responses to their specific needs. type1 type 1 type- parents qualitative descriptive conducted software support systems knowledge diet pump therapy people regimen stigma professionals emerged condition essential life needs

Resumo Objetivo Identificar os fatores que facilitam ou dificultam a construção da autonomia na adolescência através da experiência de jovens adultos com diabetes tipo 1 e seus pais. Métodos Estudo de natureza qualitativa, descritiva e exploratória. Foram realizadas duas entrevistas de grupo focal, uma com nove jovens adultos peritos na gestão de sua doença e outra com sete pais. Para análise dos dados, foram usados análise de conteúdo temática e categorial, com particularidades de entrevista de grupo focal, e recurso ao software NVIVO 12. Resultados Emergiram duas grandes categorias e dez subcategorias relativas aos fatores que facilitaram (sistemas de suporte, conhecimentos, alimentação, bomba de insulina, responsabilização precoce pela gestão da terapêutica, características dos jovens), e dificultaram (regime terapêutico, estigma, atitude dos profissionais de saúde, características dos jovens, conhecimento) o desenvolvimento da autonomia na gestão da doença. Conclusão A autonomia na gestão do diabetes envolve vários desafios aos adolescentes, o que requer adequação de atitudes e intervenções de profissionais. Além da gestão tradicional da condição de saúde, é essencial abordar temas relacionados com a socialização dos adolescentes, procurando estratégias inovadoras que promovam o coping e a qualidade de vida. Os resultados deste estudo possibilitam refletir sobre a relação terapêutica com os adolescentes, salientando a importância de individualizar cuidados e respostas inovadoras às suas necessidades específicas. pais qualitativa exploratória focal dados categorial 12 sistemas suporte conhecimentos alimentação insulina , jovens) regime terapêutico estigma saúde conhecimento adolescentes vida específicas

Abstract This study evaluated the median lethal concentration of silver nanoparticles and their effects in fish tambaqui Colossoma macropomum. Therefore, an acute toxicity assay was carried out in completely randomized design evaluating six different concentrations of silver nanoparticles on blood parameters of tambaqui. The silver nanoparticles were produced by chemical reduction with polyvinyl alcohol (AgNP-PVA). The lethal concentration 50% (LC50) was estimated using probit regression. The blood was collected, analyzed and the data were submitted to T-test (dying x surviving fish) and Tukey test (surviving fish). An increase in glucose, hematocrit, total plasma protein, hemoglobin, erythrocytes, leukocytes, monocytes, and neutrophils as well as reduced MCV (mean corpuscular volume) in dying fish compared to surviving fish were observed. Survived fish exposed to 187.5 µg/L showed an increase in hematocrit, MCV, and MCH and a reduction in erythrocytes, total numbers of leukocyte, thrombocyte, lymphocyte, and neutrophil. The fish exposed to concentrations below 125 µg/L, had returned the blood parameter to baselines compared to control. The estimated LC50 was 165.09 µg/L and was classified as highly toxic for the fish tambaqui. In higher concentrations, it causes an acute respiratory toxicity, but in concentrations below 125 µg/L, the fish can adapt to the stressing agent. macropomum Therefore AgNPPVA. AgNPPVA AgNP PVA . (AgNP-PVA) 50 LC (LC50 regression collected Ttest T fish. glucose hematocrit protein hemoglobin erythrocytes leukocytes monocytes mean volume observed 1875 187 5 187. µgL µg L leukocyte thrombocyte lymphocyte neutrophil 12 control LC5 16509 165 09 165.0 agent (AgNP-PVA (LC5 18 1 1650 16 0 165. (LC

ABSTRACT Adenosine is an antiarrhythmic drug that slows conduction through the atrioventricular node and acts as a coronary blood vessel dilator. This case report highlights two unusual life-threatening events following the use of adenosine to revert supraventricular tachycardia in a structurally normal heart: non-sustained polymorphic ventricular tachycardia and myocardial infarction. A 46-year-old woman presented to the emergency department with a two-hour history of palpitations and was diagnosed with supraventricular tachycardia. Vagal maneuvers were ineffective, and after intravenous adenosine administration, the patient presented with chest pain and hypotension. The rhythm degenerated into non-sustained polymorphic ventricular tachycardia and spontaneously reverted to sinus rhythm with ST elevation in lead aVR and ST depression in the inferior and anterolateral leads. The patient spontaneously recovered within a few minutes. Despite successful arrhythmia reversal, the patient was admitted to the intensive care unit because of an infarction without obstructive atherosclerosis. This report aims to alert emergency physicians about the potential complications associated with supraventricular tachycardia and its reversal with adenosine. dilator lifethreatening life threatening heart nonsustained non sustained 46yearold yearold 46 year old twohour hour ineffective administration hypotension leads minutes atherosclerosis 4

Abstract Postprandial lipemia (PPL) is associated with cardiovascular diseases, and it is assessed by the oral fat tolerance test (OFTT), which measures circulating triacylglycerol (TG). The objective is to propose an OFTT meal and to evaluate men’s and women’s perceptions, attitudes, sensory acceptability, and satiety. After overnight fasting, blood was collected (n=105), participants ingested the OFTT meal (75.4g lipids, 25.2g carbohydrates, and 10.8g protein/ 822.6 Kcal), and a new blood sample was collected 4h later. Fasting TG was 125.7±92.0 mg/dL (mean±SD) for men and 108.9±52.6 mg/dL for women. It increased by 97.7% and 86.7%, respectively, 4h after meal ingestion (P<0.0001), with no change in glucose. Participants felt satiated during the test. The meal was considered easy to eat and better tolerated by men. The median overall sensory acceptability was 7.0 [9-point hedonic scale]. The greatest fullness was seen in the first hour (magnitude satiety scale) and higher for women (P<0.01). The fatty meal proposed by the current study is adequate for the OFTT since it increased blood TG after 4h without hypoglycemia, it was easy to prepare, to eat, it kept participants satiated, and it displayed good perception, attitudes, and sensory acceptability. PPL (PPL diseases OFTT, , (OFTT) TG. . (TG) mens s womens perceptions attitudes fasting n=105, n105 n n=105 105 (n=105) 75.4g 754g g 75 4g lipids 252g 25 2g carbohydrates 108g 10 8g protein 8226 822 6 822. Kcal, Kcal Kcal) h later 1257920 125 7 92 0 125.7±92. mgdL mg dL mean±SD meanSD mean SD (mean±SD 1089526 108 9 52 108.9±52. 977 97 97.7 867 86 86.7% respectively P<0.0001, P00001 P P<0.0001 0001 (P<0.0001) glucose 70 7. 9point point scale. scale scale] magnitude P<0.01. P001 P<0.01 01 (P<0.01) hypoglycemia prepare perception (OFTT (TG n10 n=10 (n=105 2 1 82 125792 12 125.7±92 108952 5 108.9±52 97. 8 86.7 P0000 P<0.000 000 (P<0.0001 P00 P<0.0 (P<0.01 n1 n=1 (n=10 12579 125.7±9 10895 108.9±5 86. P000 P<0.00 00 (P<0.000 P0 P<0. (P<0.0 n= (n=1 1257 125.7± 1089 108.9± (P<0.00 P<0 (P<0. (n= 125.7 108.9 P< (P<0 (n 125. 108. (P< (P

Abstract The canned Amazon River prawn with sauce (tucupi and jambu) was thermally prepared (121 ºC) at three different times (T1: 15 T2: 20 and T3: 25 minutes) in glass bottles. The product obtained 20.86% crude protein, with good acceptance by consumers (global acceptance >7) measured through centesimal and sensory analysis of the hedonic scale. Increased exposure caused obvious changes in the sensorial characteristics of the product, which were not evidenced by consumers in the sensorial analysis, and for this reason, texture profile analysis (TPA) and color (CIELAB) were carried out, in addition to analyses of concentration of Total Volatile Basic Nitrogen (TVB-N), hydrogen potential (pH) and microbiological performed during 12 months, in addition to yield and weight loss by cooking. The sensory analysis did not show a significant difference between the treatments, however, the yield reduced with the application of heat, with the best yield being in treatment T1 (58.76 ± 0.49 a). The centesimal analysis showed excellent values of protein content of 20.86% and lipid content of 0.33%. The treatments followed the variation in color and texture according to the application of heat, mainly concerning the increase in the b* value (10.84 ± 0.70 to 13.50±0.24) and reduction in cohesiveness (0.56 ± 0.05 to 0.50 ± 0.04), gumminess (368.81± 109.23 to 262.09 ± 63.78 g) and chewiness (999.30 ± 356.92 to 633.71 ± 221.56 g). Despite this, the product proved to be safe during the analyzed period without the development of the remaining bacteria, even with an increase in pH (4.2 to 5.9) and TVB-N (20.22 to 28.46 mg/100 g), despite this, there was no development of the bacteria analyzed, proving to be a product suitable for industrial implementation. tucupi jambu 121 (12 ºC T (T1 1 T2 2 T3 minutes bottles 2086 86 20.86 global >7 7 scale reason TPA (TPA CIELAB (CIELAB out TVBN, TVBN TVB N , (TVB-N) (pH months cooking however heat 58.76 5876 58 76 (58.7 049 0 49 0.4 a. . a) 033 33 0.33% b 10.84 1084 10 84 (10.8 070 70 0.7 13.50±0.24 1350024 13 50 24 0.56 056 56 (0.5 005 05 0.0 050 0.5 0.04, 004 0.04 04 0.04) 368.81± 36881 368 81 (368.81 10923 109 23 109.2 26209 262 09 262.0 6378 63 78 63.7 g 999.30 99930 999 30 (999.3 35692 356 92 356.9 63371 633 71 633.7 22156 221 221.5 g. 4.2 42 4 (4. 5.9 59 5 9 20.22 2022 22 (20.2 2846 28 46 28.4 mg100 mg 100 mg/10 g, implementation (1 (T 208 8 20.8 > (TVB-N 58.7 587 (58. 0. 03 3 0.33 10.8 108 (10. 07 13.50±0.2 135002 (0. 00 368.81 3688 36 (368.8 1092 109. 2620 26 262. 637 6 63. 999.3 9993 99 (999. 3569 35 356. 6337 633. 2215 221. 4. (4 5. 20.2 202 (20. 284 28. mg10 mg/1 ( 20. 58. (58 0.3 10. (10 13.50±0. 13500 (0 368.8 (368. 999. (999 (20 mg1 mg/ (5 13.50±0 1350 368. (368 (99 (2 13.50± 135 (36 (9 13.50 (3 13.5 13.

ABSTRACT Objective: To evaluate questions concerning oral medicineand pharmacology-related specialties of asynchronous dental teleconsulting sessions of the Telehealth Brazil Networks Program. Material and Methods: Data were collected from secondary databases of asynchronous dental teleconsulting sessions of the telehealth centers of Minas Gerais from July 2015 to July 2017. The variables for dental underlying fields and the types of questions were evaluated. Descriptive analysis was performed with the SPSS v.22.0 program. Results: 3,920 teleconsulting sessions were referred to the telehealth centers of Minas Gerais during the study period. Regarding oral medicine-related questions (n=745), most (n=469; 62.95%) addressed diagnosis, whereas the underlying field questions mostly regarded fungal, viral, and bacterial infections (17.3%), biopsies (16.4%), developmental defects and dental abnormalities (9.9%), and soft tissue tumors (9.4%). Pharmacology-related questions (n=738) mostly addressed general approaches (n=672; 91.06%), and the most common questions were about underlying fields' prescriptions (44.7%), anesthetics (17.6%), adverse effects of medications and anesthetics (10.2%), and selection of anesthetics for patients with systemic conditions (9.8%). Conclusion: Most teleconsulting sessions regarded conditions or procedures common in primary health care and essential for diagnosis and treatment planning at all care levels, which suggests a need for more academic learning processes for healthcare professionals, especially in dentistry primary fields. Objective pharmacologyrelated pharmacology related Program Methods 201 2017 evaluated v220 v 22 0 v.22. program Results 3920 3 920 3,92 period medicinerelated medicine n=745, n745 n n=745 , 745 (n=745) n=469 n469 469 (n=469 62.95% 6295 62 95 fungal viral 17.3%, 173 17.3% 17 (17.3%) 16.4%, 164 16.4% 16 4 (16.4%) 9.9%, 99 9.9% 9 (9.9%) 9.4%. 94 9.4% . (9.4%) Pharmacologyrelated Pharmacology n=738 n738 738 (n=738 n=672 n672 672 (n=672 91.06%, 9106 91.06% 91 06 91.06%) 44.7%, 447 44.7% 44 7 (44.7%) 17.6%, 176 17.6% 6 (17.6%) 10.2%, 102 10.2% 10 2 (10.2%) 9.8%. 98 9.8% 8 (9.8%) Conclusion levels professionals 20 v22 v.22 392 92 3,9 n74 n=74 74 (n=745 n=46 n46 46 (n=46 62.95 629 17.3 1 (17.3% 16.4 (16.4% 9.9 (9.9% 9.4 (9.4% n=73 n73 73 (n=73 n=67 n67 67 (n=67 910 91.06 44.7 (44.7% 17.6 (17.6% 10.2 (10.2% 9.8 (9.8% v2 v.2 39 3, n7 n=7 (n=74 n=4 n4 (n=4 62.9 17. (17.3 16. (16.4 9. (9.9 (9.4 (n=7 n=6 n6 (n=6 91.0 44. (44.7 (17.6 10. (10.2 (9.8 v. n= (n= 62. (17. (16. (9. 91. (44. (10. (n (17 (16 (9 (44 (10 (1 ( (4

Abstract Paraquat (1,1’-dimethyl-4,4’-bipyridyl dichloride) is an herbicide widely used worldwide and officially banned in Brazil in 2020. Kidney lesions frequently occur, leading to acute kidney injury (AKI) due to exacerbated reactive O2 species (ROS) production. However, the consequences of ROS exposure on ionic transport and the regulator local renin-angiotensin-aldosterone system (RAAS) still need to be elucidated at a molecular level. This study evaluated how ROS acutely influences Na+-transporting ATPases and the renal RAAS. Adult male Wistar rats received paraquat (20 mg/kg; ip). After 24 h, we observed body weight loss and elevation of urinary flow and serum creatinine. In the renal cortex, paraquat increased ROS levels, NADPH oxidase and (Na++K+)ATPase activities, angiotensin II-type 1 receptors, tumor necrosis factor-α (TNF-α), and interleukin-6. In the medulla, paraquat increased ROS levels and NADPH oxidase activity but inhibited (Na++K+)ATPase. Paraquat induced opposite effects on the ouabain-resistant Na+-ATPase in the cortex (decrease) and medulla (increase). These alterations, except for increased serum creatinine and renal levels of TNF-α and interleukin-6, were prevented by 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (tempol; 1 mmol/L in drinking water), a stable antioxidant. In summary, after paraquat poisoning, ROS production culminated with impaired medullary function, urinary fluid loss, and disruption of Na+-transporting ATPases and angiotensin II signaling. 1,1dimethyl4,4bipyridyl 11dimethyl44bipyridyl dimethylbipyridyl 1,1 dimethyl 4,4 bipyridyl 4 dichloride 2020 occur AKI (AKI O (ROS However reninangiotensinaldosterone renin aldosterone RAAS (RAAS level Na+transporting Natransporting Na+ transporting Na 20 (2 mg/kg mgkg mg kg ip. ip . ip) 2 h Na++K+ATPase NaKATPase Na++K+ ATPase K activities IItype type receptors factorα factor α TNFα, TNFα TNF , (TNF-α) interleukin6. interleukin6 interleukin 6. 6 interleukin-6 Na++K+ATPase. ATPase. ouabainresistant ouabain resistant Na+ATPase NaATPase decrease (decrease increase. increase (increase) alterations interleukin6, 6, 4hydroxy2,2,6,6tetramethylpiperidin1oxyl 4hydroxy2266tetramethylpiperidin1oxyl hydroxytetramethylpiperidinoxyl hydroxy 2,2,6,6 tetramethylpiperidin oxyl tempol (tempol mmolL mmol L water, water water) antioxidant summary poisoning function signaling 1dimethyl4 4bipyridyl 11 1, 44 4, 202 ( NaK Na++K (TNF-α interleukin- (increase 4hydroxy2 6tetramethylpiperidin1oxyl 2266 2,2,6, 1dimethyl 4hydroxy tetramethylpiperidinoxyl 226 2,2,6 22 2,2, 2,2 2,

ABSTRACT BACKGROUND AND OBJECTIVES: The locus of control (LC) of pain is the perception of the individual about pain control. The investigation of the relationship between LC, dependence and depression in elderly patients is of great importance given the high prevalence of chronic diseases among this population. The objective of this study was to analyze the association between LC of pain in elderly patients and the level of dependence and prevalence of depression. METHODS: Ninety-one elderly individuals, aged over 60 years, were selected from the Association of Retirees, Pensioners, and Elderly of Lavras and Region (AAPIL) and all participants underwent a comprehensive anamnesis to effectively describe and characterize the sample. The Health Locus of Control Multidimensional Scale was used to assess perception of pain, the Yesavage Geriatric Depression Scale was used to determine the prevalence of depression, and Katz Index to evaluate functional capacity. Chi-square test was used to analyze nominal variables with a 95% level of significance. RESULTS: The majority of the elderly participants (83.5%) reported experiencing chronic pain, while 85.7% had no suspected depression. Internal control was the most prevalent type of LC among participants, and there was no significant relationship between LC of pain and depression. CONCLUSION: Findings suggest that the type of LC of pain reported by the elderly participants in this study does not significantly interfere with the likelihood of depression. These results contribute to the understanding of the relationship between LC, dependence, and depression among senior patients and may inform interventions to improve their quality of life. OBJECTIVES (LC population METHODS Ninetyone Ninety one individuals 6 years Retirees Pensioners AAPIL (AAPIL sample capacity Chisquare Chi square 95 significance RESULTS 83.5% 835 83 5 (83.5% 857 85 7 85.7 CONCLUSION life 9 83.5 8 (83.5 85. 83. (83. (83 (8 (

RESUMO JUSTIFICATIVA E OBJETIVOS: O lócus de controle (LC) da dor é a percepção do indivíduo sobre o controle da dor. A investigação da relação entre LC, dependência e depressão em idosos é de grande importância dada a alta prevalência de doenças crônicas nessa população. O objetivo deste estudo foi analisar a associação entre LC de dor em idosos, o grau de dependência e a prevalência de depressão. MÉTODOS: Noventa e um indivíduos idosos com idade superior a 60 anos foram selecionados na Associação de Aposentados, Pensionistas e Idosos de Lavras e Região (AAPIL), e todos os participantes passaram por uma anamnese abrangente para descrever e caracterizar efetivamente a amostra. A Escala Multidimensional de Lócus de Controle da Saúde foi usada para avaliar a percepção de dor, a Escala de Depressão Geriátrica Yesavage para determinar a prevalência de depressão e o Índice de Katz para avaliar a capacidade funcional. O teste Qui-quadrado foi utilizado para analisar variáveis nominais com nível de significância de 95%. RESULTADOS: A maioria dos idosos participantes (83,5%) relatou sentir dor crônica, enquanto 85,7% não tinham suspeita de depressão. O controle interno foi o tipo de LC mais prevalente entre os participantes, não havendo relação significativa entre LC de dor e depressão. CONCLUSÃO: Os achados sugerem que o tipo de LC da dor relatado pelos idosos participantes deste estudo não interferiu significativamente a probabilidade de depressão. Esses resultados contribuem para a compreensão da relação entre LC, dependência e depressão entre pacientes idosos e podem auxiliar em intervenções para melhorar sua qualidade de vida. OBJETIVOS (LC população MÉTODOS 6 Aposentados AAPIL, AAPIL , (AAPIL) amostra funcional Quiquadrado Qui quadrado 95 95% RESULTADOS 83,5% 835 83 5 (83,5% crônica 857 85 7 85,7 CONCLUSÃO vida (AAPIL 9 83,5 8 (83,5 85, 83, (83, (83 (8 (

BACKGROUND Eosinophils are granulocytes that rapidly increase frequency in the bloodstream during helminthic infections and allergic responses. They are found in tissue infected by Leishmania during early disease, but their role during infection is not entirely understood. OBJECTIVES We aim to compare the disease due to Leishmania amazonensis in BALB/c and Δdbl-GATA1 mice, which lack eosinophils. METHODS BALB/c and Δdbl-GATA1 mice infected with L. amazonensis were observed for several weeks. The parasite load and dissemination pattern were assessed. FINDINGS The Δdbl-GATA1 mice developed an anticipated dissemination of L. amazonensis and a worsening disease. No differences were found in the lesion development or the parasite load in the footpad among Δdbl-GATA1 mice and BALB/c eight weeks after infection. However, nine weeks after infection, massive growth of metastatic lesions appeared in several parts of the skin in Δdbl-GATA1 mice, weeks earlier than BALB/c. We observed increased parasites in the bloodstream, probably an essential dissemination route. Thirteen weeks after infection, metastatic lesions were found in all Δdbl-GATA1 mice. MAIN CONCLUSION These results suggest a protective role of eosinophils in delaying the disease caused by L. amazonensis, although several limitations of this mice strain must be considered. responses understood BALBc BALB c ΔdblGATA1 ΔdblGATA Δdbl GATA1 GATA Δdbl-GATA L assessed However route considered

ABSTRACT Objective: This study aimed to describe the clinical characteristics of the pediatric population with COVID-19 in an Emergency Department (ED) of a Brazilian general hospital. Methods: Epidemiological and clinical data of patients younger than 20 years old were collected from patients’ medical records from February 2020 to July 2021. Most of the epidemiological data described pertains to hospitalized patients. We also reviewed coinfections, treatment, and outcomes and compared the first and second waves of COVID-19. Results: We identified a total of 1303 episodes of SARS-CoV-2 infection. The median time from symptom onset to diagnosis was three days. Symptoms were present in 92.3% of the patients. The most common symptoms were fever (45.2%), nasal congestion/discharge (44.2%), and cough (39.4%). Chest radiography and tomography were performed in 7.7 and 3.3% of cases, with abnormal findings in 29.7 and 53.4%, respectively. Hospital admissions occurred in 3.5% of patients, mainly in the presence of comorbidities, in children under five years old and in those who presented to the ED during the first wave of COVID-19. Coinfection with a viral agent was identified in 20% of the 71 cases tested in this study, and a positive rapid test for Streptococcus pyogenes was found in 8% of the 174 cases tested, with no impact of these coinfections on hospitalization. Conclusions: We found that COVID-19 was a mild disease in most children in our study population, with most hospitalizations and readmissions occurring during the first wave of COVID-19. Objective COVID19 COVID 19 COVID-1 (ED hospital Methods 2 202 2021 treatment COVID19. 19. Results 130 SARSCoV2 SARSCoV SARS CoV SARS-CoV- infection days 923 92 3 92.3 45.2%, 452 45.2% , 45 (45.2%) congestiondischarge congestion discharge 44.2%, 442 44.2% 44 (44.2%) 39.4%. 394 39.4% . 39 4 (39.4%) 77 7 7. 33 3.3 297 29 29. 534 53 53.4% respectively 35 5 3.5 comorbidities 8 17 hospitalization Conclusions COVID1 1 COVID- 13 SARS-CoV 9 92. 45.2 (45.2% 44.2 (44.2% 39.4 (39.4% 3. 53.4 45. (45.2 44. (44.2 39. (39.4 53. (45. (44. (39. (45 (44 (39 (4 (3 (

RESUMO Objetivo: Este estudo teve como objetivo descrever as características clínicas da população pediátrica com COVID-19 no setor de emergência de um hospital geral brasileiro. Métodos: Os dados epidemiológicos e clínicos de pacientes idade inferior a 20 anos foram coletados dos prontuários dos pacientes de fevereiro de 2020 a julho de 2021. A maior parte dos dados epidemiológicos descritos refere-se a pacientes hospitalizados. Também foram revisados as coinfecções, o tratamento e os desfechos de internação e comparadas a primeira e a segunda ondas de COVID-19. Resultados: Foi identificado o total de 1.303 episódios de infecção por SARS-CoV-2. A mediana de tempo desde o início dos sintomas até o diagnóstico foi de três dias. Os sintomas estiveram presentes em 92,3% dos pacientes. Os sintomas mais comuns foram febre (45,2%), congestão/secreção nasal (44,2%) e tosse (39,4%). Radiografia e tomografia de tórax foram realizadas em 7,7 e 3,3% dos casos, com achados anormais em 29,7 e 53,4%, respectivamente. As internações hospitalares ocorreram em 3,5% dos pacientes, principalmente na presença de comorbidades, em crianças menores de cinco anos e naqueles que se apresentaram no pronto-socorro durante a primeira onda de COVID-19. Foi identificada coinfecção viral em 20% dos 71 casos testados e teste rápido positivo para Streptococcus pyogenes em 8% dos 174 casos testados, não havendo impacto dessas coinfecções quanto à internação hospitalar. Conclusões: Observamos que a COVID-19 foi uma doença leve na maioria das crianças de nossa população, com a maior parte das hospitalizações e readmissões ocorrendo durante a primeira onda de COVID-19. Objetivo COVID19 COVID 19 COVID-1 brasileiro Métodos 2 202 2021 referese refere hospitalizados COVID19. 19. Resultados 1303 1 303 1.30 SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. SARS-CoV-2 dias 923 92 3 92,3 45,2%, 452 45,2% , 45 (45,2%) congestãosecreção congestão secreção 44,2% 442 44 (44,2% 39,4%. 394 39,4% . 39 4 (39,4%) 77 7 7, 33 3,3 297 29 29, 534 53 53,4% respectivamente 35 5 3,5 comorbidades prontosocorro pronto socorro 8 17 hospitalar Conclusões COVID1 COVID- 130 30 1.3 SARS-CoV- 9 92, 45,2 (45,2% 44,2 (44,2 39,4 (39,4% 3, 53,4 13 1. SARS-CoV 45, (45,2 44, (44, 39, (39,4 53, (45, (44 (39, (45 (4 (39 ( (3

Abstract The aim of this study was to evaluate chemical characteristics and biological activity of progenies from the first cycle of recurrent selection of Varronia curassavica in order to identify promising progenies for the next stages of the breeding program. The seeds were collected from the parental accession VCUR-503 (chemotype E-caryophyllene/viridiflorol) and subsequently sown in seedling containers and transplanted to the field. The essential oil was extracted 300 days after transplanting, and the levels of E-caryophyllene and viridiflorol were analyzed, as well as their activity against the protozoan Ichthyophthirius multifiliis. Application of the recurrent selection method resulted in increased levels of both compounds. The levels of E-caryophyllene (0.00-23.61%) and viridiflorol (0.00-64.74%) exhibited significant variation within the population under study. The essential oil rich in viridiflorol from progenies led to high mortality (72%) of the protozoan. Promising progenies for the second cycle of recurrent selection were identified based on the variables analyzed. program VCUR503 VCUR 503 VCUR-50 chemotype Ecaryophyllene/viridiflorol Ecaryophylleneviridiflorol E caryophyllene/viridiflorol caryophyllene E-caryophyllene/viridiflorol field 30 transplanting Ecaryophyllene analyzed multifiliis compounds 0.0023.61% 0002361 0.00 23.61% 0 00 23 61 (0.00-23.61% 0.0064.74% 0006474 64.74% 64 74 (0.00-64.74% 72% 72 (72% VCUR50 50 VCUR-5 caryophylleneviridiflorol 3 0023 0.0023.61 000236 000 0.0 2361 23.61 2 6 (0.00-23.61 0064 0.0064.74 000647 6474 64.74 7 (0.00-64.74 (72 VCUR5 5 VCUR- 002 0.0023.6 00023 0. 236 23.6 (0.00-23.6 006 0.0064.7 00064 647 64.7 (0.00-64.7 (7 0.0023. 0002 23. (0.00-23. 0.0064. 0006 64. (0.00-64. ( 0.0023 (0.00-23 0.0064 (0.00-64 0.002 (0.00-2 0.006 (0.00-6 (0.00- (0.00 (0.0 (0. (0

Abstract This study evaluated the growth performance and parasite load of angelfish juveniles Pterophyllum scalare kept at different stocking densities using two rearing systems. The experiment was conducted in a factorial design (4x2) with four stocking densities (0.1, 0.4, 0.7, and 1.0 g/L), two type of aquarium tanks (glass and ceramic aquariums), and four replicates. The experiment lasted 60 days using 148 juvenile fish (3.05 ± 0.09 g) randomly placed in 32 aquariums (50 L) equipped with filters and aeration. All fish received two meals a day ad libitum (8:00 and 16:00). Water quality parameters such as temperature, dissolved oxygen, pH, and total ammonia were measured. At the end of the experiment, all fish were measured and weighed to determine growth performance and then subjected to parasitological analysis. The data were analyzed with a two-way ANOVA with post-hoc Tukey test (p<0.05). No effects on growth performance at different stocking densities were observed. However, there was an increase in Capillaria pterophylli infestation in the high stocking density within ceramic aquariums. Thus, this study recommends the use of 1.0 g/L for the intensive aquaculture system of freshwater angelfish, and applying cleaning management to avoid parasite infestation, particularly in ceramic aquariums. systems 4x2 x (4x2 0.1, 01 0 1 (0.1 04 4 0.4 07 7 0.7 10 1. g/L, gL , g L g/L) glass aquariums, aquariums) replicates 6 14 3.05 305 3 05 (3.0 009 09 0.0 50 (5 aeration 800 8 00 (8:0 1600. 1600 16 . 16:00) temperature oxygen pH analysis twoway way posthoc post hoc p<0.05. p005 p p<0.05 (p<0.05) observed However Thus 4x (4x 0.1 (0. 0. 3.0 30 (3. 5 ( 80 (8: 160 16:00 p00 p<0.0 (p<0.05 (0 3. (3 (8 16:0 p0 p<0. (p<0.0 16: p<0 (p<0. p< (p<0 (p< (p

Resumo Este estudo avaliou o desempenho de crescimento e a carga parasitária de juvenis de peixe anjo Pterophyllum scalare mantidos em diferentes densidades de estocagem usando dois sistemas de criação. O experimento foi conduzido em esquema fatorial (4 x 2) com quatro densidades de estocagem (0,1, 0,4, 0,7 e 1,0 g/L), dois aquários (aquários de vidro e cerâmica) e quatro repetições. O experimento durou 60 dias utilizando 148 peixes juvenis (3,05 ± 0,09 g) distribuídos aleatoriamente em 32 aquários (50 L) equipados com filtros e aeração. Todos os peixes receberam duas refeições diárias ad libitum (8h e 16h). Parâmetros de qualidade da água como temperatura, oxigênio dissolvido, pH e amônia total foram medidos. Ao final do experimento, todos os peixes foram medidos e pesados para determinação do desempenho de crescimento e posteriormente submetidos à análise parasitológica. Os dados foram analisados por meio de ANOVA a dois fatores com teste post-hoc de Tukey (p<0,05). Não foram observados efeitos no desempenho do crescimento em diferentes densidades de estocagem. Entretanto, houve um aumento na infestação por Capillaria pterophylli na alta densidade de estocagem dentro dos aquários cerâmicos. Assim, este estudo recomenda o uso de 1,0 g/L para o sistema intensivo de aquicultura de acarás de água doce, e aplicação de manejo de limpeza para evitar a infestação parasitária, principalmente em aquários cerâmicos. criação 4 ( 2 0,1, 01 0 1 (0,1 04 0,4 07 7 0, 10 1, g/L, gL , g L g/L) cerâmica repetições 6 14 3,05 305 3 05 (3,0 009 09 0,0 50 (5 aeração 8h h 16h. 16h . 16h) temperatura dissolvido parasitológica posthoc post hoc p<0,05. p005 p p<0,05 (p<0,05) Entretanto cerâmicos Assim doce 0,1 (0, 3,0 30 (3, 00 5 p00 p<0,0 (p<0,05 (0 3, (3 p0 p<0, (p<0,0 p<0 (p<0, p< (p<0 (p< (p

ABSTRACT The objective of this study was to examine the effect of the increasing levels of inclusion of palm kernel cake (PKC) in the diet on the performance of feedlot heifers. Forty-eight Nelore heifers with an initial weight of 274 ± 4.58 kg, at 24 months of age, were confined for 98 days in a feedlot. The animals were allocated to the four treatments in a completely randomized design. Treatments consisted of PKC levels of 0 (control), 10, 20, and 30% in the total dry matter of the diet. The roughage:concentrate ratio in the diets was 30:70. Ether extract intake increased, whereas the intakes of non-fiber carbohydrates and total digestible nutrients decreased with the inclusion of PKC. The apparent digestibility of all nutrients decreased, as well as the amounts of nitrogen digested and retained. Microbial protein synthesis and its efficiency also declined. The inclusion of up to 20% PKC increased feeding time and reduced rumination time of heifers. Intake and rumination efficiencies decreased with the inclusion of PKC in the diet. Final weight and average daily gain did not change, but feed efficiency increased with the inclusion of PKC. The inclusion of up to 30% PKC in the diet of feedlot heifers is recommended. (PKC Fortyeight Forty eight 27 458 4 58 4.5 kg 2 age 9 design control, control , (control) 10 20 30 roughageconcentrate roughage concentrate 3070. 3070 70. 70 30:70 nonfiber non fiber retained declined change recommended 45 5 4. (control 1 3 307 7 30:7 30: