RESUMO Objetivo: Descrever o perfil epidemiológico dos atendimentos em uma emergência oftalmológica de referência, sob livre demanda, em um hospital terciário no Sul brasileiro. Métodos: Realizou-se um estudo histórico transversal no Hospital Regional de São José, em Santa Catarina, abrangendo todos os atendimentos na emergência oftalmológica durante 46 dias em 2019 (n = 1.728). Os dados foram inseridos em planilha e exportados ao Statistical Package for Social Sciences, versão 21.0.0.0. A análise incluiu frequências, com o teste do qui-quadrado para dados categóricos (p < 0,05). Resultados: Dos 1.728 atendimentos, 1.365 ocorreram por livre demanda, com predominância masculina (58,5%) e média de idade 42 anos. Pacientes da Região Metropolitana de Florianópolis representaram 76,2%, associados à maior taxa de desistência na espera por consulta (p < 0,001). A taxa geral de desistência foi 12%. Queixas mais comuns foram dor (27,7%) e irritação (21,3%), apresentando-se com até 1 semana de sintomas em 74,4% dos casos. Principais diagnósticos foram corpo estranho na superfície (15,5%) e conjuntivites infecciosas (12,7%). Em 28,6% dos atendimentos, houve trauma associado. Seguimento ou cirurgia foram necessários em 39,7% dos casos, estando mais associados a encaminhamento por outro serviço de saúde. Conclusão: Muitos atendimentos foram resolvidos com baixa complexidade, destacando a importância do conhecimento epidemiológico para otimizar investimentos em saúde pública e melhorar a experiência do paciente do Sistema Único de Saúde. Objetivo referência demanda brasileiro Métodos Realizouse Realizou se José Catarina 4 201 n 1.728. 1728 . 728 1.728) Sciences 21000 21 0 21.0.0.0 frequências quiquadrado qui quadrado p 0,05. 005 0,05 05 0,05) Resultados 1.72 1365 365 1.36 58,5% 585 58 5 (58,5% anos 762 76 2 76,2% 0,001. 0001 0,001 001 0,001) 12 12% 27,7% 277 27 7 (27,7% 21,3%, 213 21,3% , 3 (21,3%) apresentandose apresentando 744 74 74,4 casos 15,5% 155 15 (15,5% 12,7%. 127 12,7% (12,7%) 286 28 6 28,6 associado 397 39 39,7 Conclusão complexidade Saúde 20 172 72 2100 21.0.0. 00 0,0 1.7 136 36 1.3 58,5 (58,5 76,2 000 0,00 27,7 (27,7 21,3 (21,3% 74, 15,5 (15,5 12,7 (12,7% 28, 39, 17 210 21.0.0 0, 1. 13 58, (58, 76, 27, (27, 21, (21,3 15, (15, 12, (12,7 21.0. (58 (27 (21, (15 (12, 21.0 (5 (2 (21 (1 (12 21. (

ABSTRACT Objective: To outline the epidemiological profile of a reference ophthalmological emergency department, with no appointment scheduled, at a tertiary hospital in Southern Brazil. Methods: A cross-sectional historical study was conducted at Hospital Regional de São José, Santa Catarina, covering all visits to the ophthalmological emergency department over 46 days in 2019 (n = 1,728). Data were entered in a spreadsheet and analyzed using Statistical Package for Social Sciences, version 21.0.0.0), with frequencies and chi-square tests for categorical data (p < 0.05). Results: Of 1,728 visits, 1,365 were with no appointment scheduled, predominantly male (58.5%), average age of 42 years. Patients from the Florianópolis Metropolitan Region represented 76.2%, associated with a higher abandonment rate (p < 0.001). The overall abandonment rate was 12%. Common complaints included pain (27.7%) and irritation (21.3%), presenting within a week in 74.4% of cases. Main diagnoses were foreign body on the surface (15.5%) and infectious conjunctivitis (12.7%). Trauma was associated in 28.6% of visits. Follow-up or surgery was required in 39.7% of cases, often associated with referral from another health service. Conclusion: Many visits were resolved with low complexity, highlighting the importance of epidemiological knowledge to optimize public health investments and enhance the Unified Health System patient experience. Objective scheduled Brazil Methods crosssectional cross sectional José Catarina 4 201 n 1,728. 1728 . 1 728 1,728) Sciences 21.0.0.0, 21000 21.0.0.0 , 21 0 21.0.0.0) chisquare chi square p 0.05. 005 0.05 05 0.05) Results 1,72 1365 365 1,36 58.5%, 585 58.5% 58 5 (58.5%) years 762 76 2 76.2% 0.001. 0001 0.001 001 0.001) 12 12% 27.7% 277 27 7 (27.7% 21.3%, 213 21.3% 3 (21.3%) 744 74 74.4 cases 15.5% 155 15 (15.5% 12.7%. 127 12.7% (12.7%) 286 28 6 28.6 Followup Follow up 397 39 39.7 service Conclusion complexity experience 20 172 72 2100 21.0.0. 00 0.0 1,7 136 36 1,3 58.5 (58.5% 76.2 000 0.00 27.7 (27.7 21.3 (21.3% 74. 15.5 (15.5 12.7 (12.7% 28. 39. 17 210 21.0.0 0. 1, 13 58. (58.5 76. 27. (27. 21. (21.3 15. (15. 12. (12.7 21.0. (58. (27 (21. (15 (12. 21.0 (58 (2 (21 (1 (12 (5 (

Resumo O tétano é uma doença grave e rara em pequenos animais, de caráter agudo e mediada pela ação da neurotoxina tetanospasmina, proveniente do bacilo Clostridium tetani. Neste relato descreve-se um caso de tétano em um canino, com ênfase em seus aspectos clínicos e terapêuticos, além da sua recuperação clínica. Foi atendido no Hospital Veterinário da Universidade de Passo Fundo, um canino, fêmea, da raça Pitbull, com cinco meses, em status epilepticus. Após a estabilização da paciente, constataram-se animal em posição de cavalete, com paralisia espástica generalizada, risus sardonicus, trismo, cauda e orelhas eretas e dificuldade em expandir o tórax. O diagnóstico presuntivo de tétano foi firmado a partir da anamnese, sinais clínicos e achados laboratoriais. O tratamento suporte estabelecido incluiu reposição hidroeletrolítica, soro antitetânico, antibioticoterapia, analgesia, fármacos miorrelaxantes e anticonvulsivantes. O manejo intensivo da paciente foi realizado com sondagem uretral e nasoesofágica, trocas de decúbito a cada duas horas e diminuição de estímulos ambientais. A fisioterapia e a acupuntura também foram utilizadas para complementar o tratamento e acelerar a recuperação. A paciente recebeu alta médica um mês após o início do tratamento, apresentando evolução satisfatória. No presente caso, o exame clínico em associação aos sinais clínicos característicos da doença, acrescidos da anamnese minuciosa foram fundamentais ao diagnóstico presuntivo de tétano. Além disso, o manejo intensivo, o tratamento medicamentoso, assim como a realização de fisioterapia e acupuntura, possibilitaram a evolução do quadro clínico à cura.

Abstract Tetanus is a serious and rare disease in small animals, of an acute nature and mediated by the action of the neurotoxin tetanospasmin, from the bacillus Clostridium tetani. This report describes a case of tetanus in a canine, with emphasis on its clinical and therapeutic aspects, in addition to its clinical recovery. A canine, female, Pitbull breed, five months old, in status epilepticus, was attended at the Veterinary Hospital of the University of Passo Fundo. After stabilizing the patient, the animal was found in a trestle position, with generalized spastic paralysis, risus sardonicus, trismus, erect tail and ears, and difficulty in expanding the thorax. The presumptive diagnosis of tetanus was established based on the anamnesis, clinical signs, and laboratory findings. The established supportive treatment included hydro electrolytic replacement, antitetanus serum, antibiotic therapy, analgesia, myorelaxant and anticonvulsant drugs. The patient's intensive management was carried out with urethral and gastroesophageal probing, changes of position every two hours, and reduction of environmental stimuli. Physiotherapy and acupuncture were also used to complement the treatment and accelerate recovery. The patient was discharged one month after the beginning of the treatment, presenting satisfactory evolution. In the present case, the clinical examination in association with the characteristic clinical signs of the disease, added to the detailed anamnesis, was essential for the presumptive diagnosis of tetanus. In addition, intensive management, drug treatment, physiotherapy, and acupuncture enabled the evolution of the clinical condition to cure.

Abstract Tetanus is a serious and rare disease in small animals, of an acute nature and mediated by the action of the neurotoxin tetanospasmin, from the bacillus Clostridium tetani. This report describes a case of tetanus in a canine, with emphasis on its clinical and therapeutic aspects, in addition to its clinical recovery. A canine, female, Pitbull breed, five months old, in status epilepticus, was attended at the Veterinary Hospital of the University of Passo Fundo. After stabilizing the patient, the animal was found in a trestle position, with generalized spastic paralysis, risus sardonicus, trismus, erect tail and ears, and difficulty in expanding the thorax. The presumptive diagnosis of tetanus was established based on the anamnesis, clinical signs, and laboratory findings. The established supportive treatment included hydro electrolytic replacement, antitetanus serum, antibiotic therapy, analgesia, myorelaxant and anticonvulsant drugs. The patient's intensive management was carried out with urethral and gastroesophageal probing, changes of position every two hours, and reduction of environmental stimuli. Physiotherapy and acupuncture were also used to complement the treatment and accelerate recovery. The patient was discharged one month after the beginning of the treatment, presenting satisfactory evolution. In the present case, the clinical examination in association with the characteristic clinical signs of the disease, added to the detailed anamnesis, was essential for the presumptive diagnosis of tetanus. In addition, intensive management, drug treatment, physiotherapy, and acupuncture enabled the evolution of the clinical condition to cure. animals tetanospasmin tetani canine aspects recovery female breed old epilepticus Fundo paralysis sardonicus trismus ears thorax anamnesis findings replacement serum therapy analgesia drugs patients s probing hours stimuli physiotherapy cure

Resumo O tétano é uma doença grave e rara em pequenos animais, de caráter agudo e mediada pela ação da neurotoxina tetanospasmina, proveniente do bacilo Clostridium tetani. Neste relato descreve-se um caso de tétano em um canino, com ênfase em seus aspectos clínicos e terapêuticos, além da sua recuperação clínica. Foi atendido no Hospital Veterinário da Universidade de Passo Fundo, um canino, fêmea, da raça Pitbull, com cinco meses, em status epilepticus. Após a estabilização da paciente, constataram-se animal em posição de cavalete, com paralisia espástica generalizada, risus sardonicus, trismo, cauda e orelhas eretas e dificuldade em expandir o tórax. O diagnóstico presuntivo de tétano foi firmado a partir da anamnese, sinais clínicos e achados laboratoriais. O tratamento suporte estabelecido incluiu reposição hidroeletrolítica, soro antitetânico, antibioticoterapia, analgesia, fármacos miorrelaxantes e anticonvulsivantes. O manejo intensivo da paciente foi realizado com sondagem uretral e nasoesofágica, trocas de decúbito a cada duas horas e diminuição de estímulos ambientais. A fisioterapia e a acupuntura também foram utilizadas para complementar o tratamento e acelerar a recuperação. A paciente recebeu alta médica um mês após o início do tratamento, apresentando evolução satisfatória. No presente caso, o exame clínico em associação aos sinais clínicos característicos da doença, acrescidos da anamnese minuciosa foram fundamentais ao diagnóstico presuntivo de tétano. Além disso, o manejo intensivo, o tratamento medicamentoso, assim como a realização de fisioterapia e acupuntura, possibilitaram a evolução do quadro clínico à cura. animais tetanospasmina tetani descrevese descreve se canino terapêuticos clínica Fundo fêmea Pitbull meses epilepticus constataramse constataram cavalete generalizada sardonicus trismo tórax laboratoriais hidroeletrolítica antitetânico antibioticoterapia analgesia anticonvulsivantes nasoesofágica ambientais satisfatória disso medicamentoso cura

Abstract Background Short message service (SMS) to promote healthcare improves the control of cardiovascular risk factors, but there is a lack of evidence in low and middle-income countries, particularly after acute coronary syndromes (ACS). Objective This study aims to evaluate whether the use of SMS increases risk factor control after hospital discharge for ACS. Methods IMPACS is a 2-arm randomized trial with 180 patients hospitalized due to ACS at a tertiary hospital in Brazil. Eligible patients were randomized (1:1) to an SMS intervention (G1) or standard care (G2) upon hospital discharge. The primary endpoint was set to achieve 4 or 5 points in a risk factor control score, consisting of a cluster of 5 modifiable risk factors: LDL-C <70mg/dL, blood pressure (BP) <140/90mmHg, regular exercise (≥5 days/week, 30 minutes/session), nonsmoker status, and body mass index (BMI) <25 kg/m2] at 6 months. Secondary outcomes were components of the primary outcome plus rehospitalization, cardiovascular death, and death from any cause. Results are designated as significant if p<0.05. Results From randomized patients, 147 were included in the final analysis. Mean age was 58 (51–64) years, 74% males. The primary outcome was achieved by 12 (16.2%) patients in G1 and 15 (20.8%) in G2 (OR=0.73, 95%CI 0.32–1.70, p=0.47). Secondary outcomes were also similar: LDL-C<70 mg/dl (p=0.33), BP<140/90 mmHg (p=0.32), non-smoker (p=0.74), regular exercise (p=0.97), BMI (p=0.71), and rehospitalization (p=0.06). Death from any cause occurred in three participants (2%), including one cardiovascular death in each group. Conclusion SMS intervention did not significantly improve cardiovascular risk factor control when compared to standard care in patients discharged after ACS in Brazil.

Resumo O excessivo consumo de suplementos alimentares, aliado a uma legislação inespecífica e a um controle de qualidade ineficiente, faz com que a saúde dos consumidores seja colocada em risco devido à possível existência de contaminantes, em especial pró-hormônios, esteroides anabolizantes e estimulantes. Estes compostos podem proporcionar um aumento do desempenho esportivo e acarretar uma série de efeitos adversos, sendo assim proibidos pela Agência Mundial Antidopagem. A contaminação de suplementos pode ocorrer de maneira deliberada ou através de más práticas de produção, em que são encontrados traços dessas substâncias. Todavia, ambos os casos exigem atenção, já que uma contaminação de apenas 0,00005% em massa pode levar ao doping. Neste sentido, estima-se que de 6,4% a 8,8% dos casos estejam relacionados ao consumo de suplementos contaminados. Perante estes fatos, os objetivos principais do trabalho foram: fazer uma revisão da literatura tanto em trabalhos nacionais quanto internacionais, no que concerne à contaminação de suplementos alimentares e sua relação com a dopagem não intencional, bem como orientar os consumidores a escolherem produtos mais seguros. Neste sentido, foi possível observar que os suplementos nacionais são, geralmente, mais seguros quanto à presença de substâncias proibidas, principalmente em relação à contaminação por agentes anabolizantes. Contudo, ainda é preciso um melhor controle de qualidade perante a contaminação/adulteração por estimulantes.

Abstract The excessive consumption of food supplements, allied to unspecified legislation and inefficient quality control, can put in risk to the consumer’s health because of the possible presence of contaminants, especially prohormones, anabolic steroids, and stimulants. These compounds can enhance sports performance and lead to a number of adverse effects, so they are prohibited by the World Anti-Doping Agency. Supplement contamination can occur deliberately or through poor manufacturing, in which traces of these substances are found. However, both cases require attention, as a contamination of only 0.00005% in mass can result in doping. Therefore, it is estimated that 6.4% to 8.8% of these cases are related to the consumption of contaminated supplements. Thus, the main objectives of this article were: to review the national and international literature regarding the contamination of food supplements and its relation to unintended doping, as well as to guide consumers to choose safer sources. In this sense, it was possible to observe that national supplements are generally safer in terms of the presence of prohibited substances, especially in relation to contamination of anabolic agents. On the other hand, there is still a need for better quality control regarding the contamination/adulteration of stimulants.

Resumo Esse estudo teve como objetivo determinar os fatores associados à dependência para atividades instrumentais da vida diária em idosos. Realizou-se um estudo caso-controle de base populacional, com 180 idosos de Passo Fundo-RS, 2014. Os casos foram representados por 60 indivíduos com idade ≥ 60 anos, dependentes para as atividades instrumentais de vida diária residentes nos domicílios urbanos do município. Os controles foram representados por 120 idosos, não dependentes para atividades instrumentais de vida diária, residentes nos domicílios urbanos do município. Para testar a associação entre o desfecho e as variáveis independentes, foram realizadas as análises brutas e multivariáveis mediante regressão de Poisson, estimando-se as razões de chance (OR) brutas e ajustadas e calculados os respectivos intervalos de confiança de 95%. Entraram no modelo múltiplo todas as variáveis com p ≤ 0,20. Permaneceram estatisticamente significativos após análise ajustada: estar na faixa etária de 80 anos ou mais (OR = 1,76; IC95%: 1,01-3,08), ter estudado de 1 a 4 anos (OR = 2,36; IC95%: 1,35-4,14), ser analfabeto (OR = 2,98; IC95%: 1,52-5,84), ter diagnóstico de Parkinson (OR = 2,44; IC95%: 1,39-4,29) e apresentar comprometimento cognitivo (OR = 1,88; IC95%: 1,30-2,72).

Abstract The main goal of the study was to determine the factors associated with dependence to perform instrumental activities of daily living in the elderly. A population-based case-control study was conducted, with 180 elderly people from Passo Fundo-RS, 2014. The cases were represented by 60 individuals aged ≥ 60 years, dependents to perform instrumental activities of daily living residents of the urban area of the city. The controls were represented by 120 individuals, not dependents to perform instrumental activities of daily living, residents of the urban area of the city. Crude and multivariate analysis using Poisson regression were performed to test the association between the outcome and the independent variables, estimating the crude and adjusted odds ratios (OR) and calculating the 95% confidence intervals respectively. All the variables with p ≤ 0.20 were included in the final model. Remained statistically significant after adjusted analysis: being aged 80 years or more (OR = 1.76; CI95%: 1.01-3.08), having studied from 1 to 4 years (OR = 2.36; CI95%: 1.35-4.14), being illiterate (OR = 2.98; CI95%: 1.52-5.84), having Parkinson’s disease (OR = 2.44; CI95%: 1.39-4.29) and the presence of cognitive impairment (OR = 1.88; CI95%: 1.30-2.72).

ABSTRACT This study aimed to evaluate the effectiveness of a Yoga program in improving the self-esteem and self-image of the elderly. Thirty-six elderly individuals were evaluated, divided into two groups. The program lasted 2 months and was practiced 3 times a week, with a duration of 60 minutes each class. A structured and validated questionnaire was used to assess self-esteem and self-image. The elderly had a mean age of 60.5 ± 2.86 years, height of 1.66 ± 0.03 meters, and body mass of 69 ± 5.17 kg. For self-image an F = 52.36 was verified; p<0.001 and for self-esteem F = 48.78; p<0.001. It can be concluded in this research that the practice of yoga is effective in improving the levels of self-esteem and self-image of the elderly, it can be used through the therapeutic effects of exercise in the non-pharmacological treatment and prophylaxis of some psychiatric illness such as depression.

Resumo Esta pesquisa teve por objetivo verificar os fatores associados entre o conhecimento e a atitude sobre diabetes mellitus tipo 2 em idosos com a doença. Realizou-se um estudo transversal de base populacional com 204 idosos da rede pública de saúde de Passo Fundo, RS. Para a coleta de dados utilizou-se os questionários: sociodemográfico, de conhecimento DKN-A, de atitudes psicológicas do diabetes ATT-19 e o IPAQ para atividade física. Foi utilizada a regressão logística para as variáveis sociodemográficas, de saúde e os indicadores de adiposidade corporal. Foram realizadas análises brutas e ajustadas com um intervalo de confiança de 95%. Os resultados deste estudo identificaram que o bom conhecimento está associado com a idade maior ou igual 70 anos (OR = 0,44; IC95%: 0,18-1,08), ter atitude positiva para o tratamento da diabetes (OR = 10,4 IC95%: 4,20-18,70) e ser ativo fisicamente (OR = 12,7; IC95%: 6,8-30,10). Na associação com a atitude positiva se manteve associada significativamente a idade maior ou igual 70 anos (OR = 0,35; IC95%: 0,15-0,78), ter um bom conhecimento da diabetes (OR = 8,9; IC95%: 4,30-18,9) e ser ativo fisicamente (OR = 10,1; IC95%: 6,34-20,1). Portanto, o bom conhecimento e a atitude positiva estão associados à idade de 70 anos a mais e ser ativo fisicamente.

Abstract The aim of this study was to identify the factors associated with knowledge and attitude towards type 2 diabetes mellitus among older adults with the disease. A cross-sectional population-based study was conducted on 204 older adults from the public healthcare network of Passo Fundo, RS. Sociodemographic data were collected and the DKN-A, ATT-19 and IPAQ were used for the assessment of diabetes knowledge, psychological attitudes towards diabetes and physical activity, respectively. Logistic regression was applied to evaluate the association with sociodemographic and health variables and indicators of body adiposity. Crude and adjusted analyses were performed with a 95% confidence interval. The results showed that good knowledge is associated with age ≥ 70 years (OR = 0.44; 95%CI: 0.18-1.08), having a positive attitude towards diabetes treatment (OR = 8.9; 95%CI: 4.3-18.9), and being physically active (OR = 10.1; 95%CI: 6.34-20.1). In conclusion, good knowledge and a positive attitude towards diabetes are associated with age older than 70 years and being physically active.

Resumo Esta pesquisa teve por objetivo verificar os fatores associados entre o conhecimento e a atitude sobre diabetes mellitus tipo 2 em idosos com a doença. Realizou-se um estudo transversal de base populacional com 204 idosos da rede pública de saúde de Passo Fundo, RS. Para a coleta de dados utilizou-se os questionários: sociodemográfico, de conhecimento DKN-A, de atitudes psicológicas do diabetes ATT-19 e o IPAQ para atividade física. Foi utilizada a regressão logística para as variáveis sociodemográficas, de saúde e os indicadores de adiposidade corporal. Foram realizadas análises brutas e ajustadas com um intervalo de confiança de 95%. Os resultados deste estudo identificaram que o bom conhecimento está associado com a idade maior ou igual 70 anos (OR = 0,44; IC95%: 0,18-1,08), ter atitude positiva para o tratamento da diabetes (OR = 10,4 IC95%: 4,20-18,70) e ser ativo fisicamente (OR = 12,7; IC95%: 6,8-30,10). Na associação com a atitude positiva se manteve associada significativamente a idade maior ou igual 70 anos (OR = 0,35; IC95%: 0,15-0,78), ter um bom conhecimento da diabetes (OR = 8,9; IC95%: 4,30-18,9) e ser ativo fisicamente (OR = 10,1; IC95%: 6,34-20,1). Portanto, o bom conhecimento e a atitude positiva estão associados à idade de 70 anos a mais e ser ativo fisicamente.

Abstract The aim of this study was to identify the factors associated with knowledge and attitude towards type 2 diabetes mellitus among older adults with the disease. A cross-sectional population-based study was conducted on 204 older adults from the public healthcare network of Passo Fundo, RS. Sociodemographic data were collected and the DKN-A, ATT-19 and IPAQ were used for the assessment of diabetes knowledge, psychological attitudes towards diabetes and physical activity, respectively. Logistic regression was applied to evaluate the association with sociodemographic and health variables and indicators of body adiposity. Crude and adjusted analyses were performed with a 95% confidence interval. The results showed that good knowledge is associated with age ≥ 70 years (OR = 0.44; 95%CI: 0.18-1.08), having a positive attitude towards diabetes treatment (OR = 8.9; 95%CI: 4.3-18.9), and being physically active (OR = 10.1; 95%CI: 6.34-20.1). In conclusion, good knowledge and a positive attitude towards diabetes are associated with age older than 70 years and being physically active.

Resumo O objetivo do presente estudo foi avaliar os compostos fenólicos e a capacidade antioxidante da semente e da torta da semente de faveleira. Os perfis fenólicos foram avaliados por cromatografia líquida de ultra alta eficiência. Além disso, o conteúdo fenólico total e a eliminação do radical DPPH (2,2-diphenyl-1-picrylhydrazyl) foram avaliados. A torta e a semente de faveleira são fontes de compostos fenólicos naturais para dieta humana e possuem potente atividade antioxidante. O ácido gálico foi o composto fenólico predominante na semente e na torta. O estudo mostrou que a torta e a semente de faveleira podem ser consideradas alimentos funcionais e de interesse potencial para a indústria de alimentos.

Abstract The objective of the present study was to assess the phenolic compounds and antioxidant capacity of faveleira seed and press cake extracts. Phenolic profiles were assessed by Ultra-High Performance Liquid Chromatography (UHPLC). Furthermore, the Total Phenolic Content (TPC) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging were evaluated. The faveleira seed and press cake extracts are sources of natural phenolic compounds in human diet and have potent antioxidant activity. Gallic acid was the predominant phenolic compound in seed and press cake extracts. The study showed that faveleira seed and press cake extracts can be considered functional foods as well as a potential interest to the food industry.

Resumo Esse estudo teve como objetivo determinar os fatores associados à dependência para atividades instrumentais da vida diária em idosos. Realizou-se um estudo caso-controle de base populacional, com 180 idosos de Passo Fundo-RS, 2014. Os casos foram representados por 60 indivíduos com idade ≥ 60 anos, dependentes para as atividades instrumentais de vida diária residentes nos domicílios urbanos do município. Os controles foram representados por 120 idosos, não dependentes para atividades instrumentais de vida diária, residentes nos domicílios urbanos do município. Para testar a associação entre o desfecho e as variáveis independentes, foram realizadas as análises brutas e multivariáveis mediante regressão de Poisson, estimando-se as razões de chance (OR) brutas e ajustadas e calculados os respectivos intervalos de confiança de 95%. Entraram no modelo múltiplo todas as variáveis com p ≤ 0,20. Permaneceram estatisticamente significativos após análise ajustada: estar na faixa etária de 80 anos ou mais (OR = 1,76; IC95%: 1,01-3,08), ter estudado de 1 a 4 anos (OR = 2,36; IC95%: 1,35-4,14), ser analfabeto (OR = 2,98; IC95%: 1,52-5,84), ter diagnóstico de Parkinson (OR = 2,44; IC95%: 1,39-4,29) e apresentar comprometimento cognitivo (OR = 1,88; IC95%: 1,30-2,72).

Abstract The main goal of the study was to determine the factors associated with dependence to perform instrumental activities of daily living in the elderly. A population-based case-control study was conducted, with 180 elderly people from Passo Fundo-RS, 2014. The cases were represented by 60 individuals aged ≥ 60 years, dependents to perform instrumental activities of daily living residents of the urban area of the city. The controls were represented by 120 individuals, not dependents to perform instrumental activities of daily living, residents of the urban area of the city. Crude and multivariate analysis using Poisson regression were performed to test the association between the outcome and the independent variables, estimating the crude and adjusted odds ratios (OR) and calculating the 95% confidence intervals respectively. All the variables with p ≤ 0.20 were included in the final model. Remained statistically significant after adjusted analysis: being aged 80 years or more (OR = 1.76; CI95%: 1.01-3.08), having studied from 1 to 4 years (OR = 2.36; CI95%: 1.35-4.14), being illiterate (OR = 2.98; CI95%: 1.52-5.84), having Parkinson’s disease (OR = 2.44; CI95%: 1.39-4.29) and the presence of cognitive impairment (OR = 1.88; CI95%: 1.30-2.72).

Methasterone is a designer anabolic steroid that is prohibited for athletes and is monitored by anti-doping laboratories. In this work, our objective is to discover new human phase I metabolites, define their excretion kinetics for 30 days and analyze their phase II metabolism (sulfate, cysteine and N-acetylcysteine conjugates). Urine samples from four volunteers were analyzed by chromatographic techniques. Through gas chromatography coupled to mass spectrometry analysis it was possible to detect methasterone and its nine phase I metabolites in the urine samples after glucuronide enzymatic hydrolysis, from which one were previously unreported. These nine compounds were not excreted in free form. The new proposed metabolite is 17β-hydroxy-2α,17α-dimethyl-5β-androstan-3-one, obtained from the epimerization at C5. The 3α-hydroxy metabolite, currently monitored by anti-doping laboratories, was the most abundant and was detected for the longest time. Furthermore, four other long-term metabolites were identified. By ultra-performance liquid chromatography coupled to tandem mass spectrometry, only the drug and a known metabolite were detected after glucuronide hydrolysis, and phase II metabolites were not found. Thus, our results contribute to elucidating methasterone metabolism, including long-term metabolites besides of the 3α-hydroxy in routine doping analysis, which is very important due to variation in human metabolism.

RESUMO Introdução O aumento das doenças crônicas e da inatividade física são problemas importantes de saúde pública da população idosa do mundo. Objetivo Este artigo objetivou determinar a prevalência e os fatores associados à prática de atividade física (AF) entre idosos domiciliados em ambiente urbano. Métodos Um estudo transversal de base populacional foi realizado em 2014, com 196 idosos com ≥ 60 anos que vivem em ambiente urbano do município de Passo Fundo, RS. Foram realizadas análises bruta e multivariável mediante regressão de Poisson, estimando-se as razões de prevalência bruta e ajustada, calculando-se os respectivos intervalos de confiança de 95%. Resultados A média de idade foi de 71,3 (± 8,4). A prevalência bruta de prática de AF foi de 56,1%. Depois de ajuste da análise, somente a variável independente das atividades da vida diária (AVD) permaneceu significativa (IC de 95% 1,05-4,83) (p = 0,037). Conclusões Esta pesquisa mostrou associação entre a prática de AF e independência nas AVD. Nível de Evidência II, Análises econômicas e de decisão – Desenvolvimento de modelo econômico ou de decisão.

ABSTRACT Introduction The increase in chronic diseases and physical inactivity are major public health problems among elderly populations worldwide. Objective This article aimed to determine the prevalence and factors associated with the practice of physical activity (PA) among elderly people living in urban environment. Methods A cross-population-based study was conducted in 2014, with 196 elderly people aged ≥ 60 years of age living in urban environment in the city of Passo Fundo, in the State of Rio Grande do Sul. Gross and multivariable analyses were conducted using Poisson regression, estimating the ratios of gross and adjusted prevalence and calculating their respective 95% confidence intervals. Results The mean age was 71.3 (± 8.4). The gross prevalence for the practice of PA was 56.1%. After adjusted analysis, only the variable independent in activities of daily living (ADLs) remained significant (95% CI 1.05 to 4.83) (p = 0.037). Conclusions This research showed an association between the practice of PA and independence in ADLs. Level of Evidence II, Economic and decision analysis - Development of economic model or decision.

RESUMEN Introducción El aumento de las enfermedades crónicas y la falta de actividad física son los principales problemas de salud pública entre las poblaciones de edad avanzada en todo el mundo. Objetivo Este artículo tiene como objetivo determinar la prevalencia y los factores asociados con la práctica de actividad física (AF) entre ancianos que viven en entornos urbanos. Métodos En 2014, se realizó un estudio basado en poblaciones cruzadas, con 196 personas con ≥ 60 años de edad que viven en entornos urbanos en la ciudad de Passo Fundo en el estado de Rio Grande do Sul. Se realizaron análisis brutos y multivariables mediante la regresión de Poisson, estimando los ratios de prevalencia bruta y ajustada y calculando sus respectivos intervalos de confianza del 95%. Resultados La edad media fue de 71,3 (± 8,4). La prevalencia bruta de la práctica de AF fue 56,1%. Después del ajuste del análisis, sólo la variable independiente en las actividades de la vida diaria (AVD) se mantuvo significativa (IC del 95%: 1,05 a 4,83) (p = 0,037). Conclusiones Este estudio mostró asociación entre la AF y la independencia en las AVD . Nivel de evidencia II, Análisis económico y de decisión - Desarrollo de modelo económico o de decisión.

Polystyrene (PS) is one of the most widely used polymers in the world, having a wide applicability. PS can be used in pure or modified forms, and the commercial materials most used for modifications are non-renewable and have high costs. For this reason, studies have been carried in order to evaluate renewable components application such as vegetable oils, for this purpose. In this context, different materials have been prepared from styrene (STY) and the common fatty oleic acid (FA) modified with allyl alcohol through esterification in acid catalysis. The allyl oleate (AOL) was obtained with yield of 89% (w/w) and it was submitted to a reaction with styrene at variable concentrations. The copolymers (PS-AOL) were obtained and characterized by conventional techniques. The results indicated that the copolymerization occurred. Therefore, the proposed methodology allows the compatibilization between a renewable matrix and PS for the new materials obtaining.