Abstract Biotechnology offers solutions and opportunities to meet various societal demands, thereby contributing to significant scientific advancements. This study aimed to characterize the technological development of biotechnology in the healthcare sector in the state of Rio Grande do Sul, Brazil, from 2016 to 2022 by analyzing patents filed by and granted to public and private Higher Education institutions. For data collection, a quantitative exploratory approach was employed using statistical methods and a patent analysis of institutions in the patent database of the Brazilian National Institute of Industrial Property (INPI), focusing on patents related to the healthcare field. Data were collected in October, November, and December. A total of 580 patent records were collected from the INPI, belonging to Sections A and C of the International Patent Classification (IPC) related to educational institutions. Furthermore, this study highlighted that higher education institutions have a higher number of patents in the healthcare field. These results provide an understanding of the strategic areas for technological development in biotechnology in Rio Grande do Sul, Brazil. demands advancements Sul Brazil 201 202 collection INPI , (INPI) field October November December 58 IPC (IPC Furthermore 20 (INPI 5 2

Abstract Researchers have associated the therapeutic potential of probiotics with its ability to modulate gut microbiota, which is considered an “invisible organ” of the human body. The present study investigates the effects of probiotic supplementation on the gut microbiota composition of adults. The authors conducted a systematic review of the literature published in six different databases. The search followed PRISMA guidelines and aimed to identify randomized clinical trials on probiotic supplementation. All relevant publications indexed up to May 28, 2021, were retrieved. Then, the authors defined the inclusion and exclusion criteria. Two independent reviewers performed study screening, data extraction, and quality assessment. A total of 2,404 publications were retrieved, and eight studies met the eligibility criteria. The included randomized clinical trials were published between 2015 to 2020. The worldwide studies included adults aged from 18 to 79 years, most of whom were women (66.5%). Only one of the included studies observed significant effects on fecal microbiota composition in the relative abundance of Bacteroidetes and Firmicutes phyla in comparison with the placebo treatment. Overall, this systematic review could not draw consistent conclusions on the effects of probiotic supplementation on the gut microbiota composition of adults. invisible organ body databases 28 2021 retrieved Then criteria screening extraction assessment 2404 2 404 2,40 201 2020 1 7 years 66.5%. 665 66.5% . 66 5 (66.5%) treatment Overall 202 240 40 2,4 20 66.5 6 (66.5% 24 4 2, 66. (66.5 (66. (66 (6 (

Abstract The aim of this study was to use bibliometric techniques to provide a longitudinal view of the evolution over more than 50 years of the literature on esophageal cancer without focusing on a specific area. The Web of Science Core Collection database was searched for published articles on esophageal neoplasm. Different aspects of the articles were analyzed - country, journal, authors, keywords, and topics. The search returned 24,215 articles - the journal Diseases of the Esophagus present the most number of manuscripts (n = 858), followed by Annals of Surgical Oncology (n = 475).The most cited article was one by van Hagen et al. (2012) (2,807 citations). The most prevalent topic was oncology (n = 10,448), followed by surgery (n = 4,944). Most articles were original research (n = 22,697), mainly with the basic science study design and published by institutions in China. The analysis of the variables chosen, identified China as the country with the highest number of articles and showed that authors and institutions in Asia stand out when it comes to production of scientific information on esophageal cancer. 5 area neoplasm keywords topics 24215 24 215 24,21 n 858, 858 , 858) 475.The 475The 475 .The al 2012 (2012 2,807 2807 2 807 (2,80 citations. citations . citations) 10,448, 10448 10,448 10 448 10,448) 4,944. 4944 4,944 4 944 4,944) 22,697, 22697 22,697 22 697 22,697) chosen 2421 21 24,2 85 47 201 (201 2,80 280 80 (2,8 1044 10,44 1 44 494 4,94 94 2269 22,69 69 242 24, 8 20 (20 2,8 28 (2, 104 10,4 49 4,9 9 226 22,6 6 (2 2, 10, 4, 22, (

Resumo Objetivos O objetivo do estudo foi avaliar o itinerário terapêutico de pacientes tratados em um centro especializado, compreendendo sua trajetória na busca do tratamento e as características clínicas e epidemiológicas. Métodos estudo descritivo prospectivo transversal; foram incluídos na análise pacientes portadores de câncer colorretal (CCR) maiores de 18 anos que assinaram o termo de consentimento. Foram avaliadas características tumorais, como estadiamento e características do tumor; características epidemiológicas como idade, sexo e profissão e a trajetória como número de consultas até o diagnóstico, principais sintomas e tempo médio entre o diagnóstico e início do tratamento. Resultados 34% dos pacientes procuraram inicialmente a atenção primária (primeiro nível de atenção na saúde pública), 50% receberam o diagnóstico na atenção secundária (segundo nível de atenção na saúde pública), a média de consultas até o diagnóstico foi de 2,5 vezes, 52% dos pacientes fizeram terapia paliativa e 40% fizeram diagnóstico em estádio IV. Conclusões o tempo médio entre o diagnóstico e o início do tratamento está de acordo com o recomendado pelo Ministério da Saúde do Brasil; entretanto, identificou-se que os pacientes desconhecem os sintomas da doença, uma vez que a média de tempo entre o início dos sintomas até a tomada de decisão de procurar um médico foi de 177 dias, o que pode ter sido determinante para um diagnóstico na fase avançada da doença.

Abstract Objectives The objective of the study was to evaluate the therapeutic itinerary of patients treated in a specialized center, including its trajectory in seeking treatment and their clinical and epidemiological characteristics. Methods This is a cross-sectional prospective descriptive study; patients with colorectal cancer aged over 18 years and who signed the consent form were included in the analysis. Tumor characteristics, such as staging and tumor features; epidemiological characteristics such as age, gender, profession and itinerary in the form of the number of clinical visits needed to obtain the diagnosis; the main symptoms; and mean time between diagnosis and onset of treatment were evaluated. Results 34% of patients initially sought primary care (first level of care in the public health system) and 50% were diagnosed in secondary care (second level of care in the public health system); the mean number of visits until obtaining a diagnosis was 2.5 times; and 52% of patients received palliative therapy and 40% had a stage IV diagnosis. Conclusions The mean time between the diagnosis and the onset of treatment is in line with the recommendations of the Ministry of Health of Brazil. However, it was found that the patients are unaware of the symptoms of the disease, since the mean time between the onset of symptoms until the decision to visit the doctor was 177 days – which may have been a determining factor for a diagnosis in an advanced stage of disease.