ABSTRACT Several enzymatic reactions of heteroatom-containing compounds have been explored as unnatural substrates. Considerable advances related to the search for efficient enzymatic systems able to support a broader substrate scope with high catalytic performance are described in the literature. These reports include mainly native and mutated enzymes and whole cells biocatalysis. Herein, we describe the historical background along with the progress of biocatalyzed reactions involving the heteroatom(S, Se, B, P and Si) from hetero-organic substrates.

A influência de grupos protetores na síntese régio- e estereosseletiva de teluretos vinílicos preparados a partir de BuTeNa e álcoois propargílicos e homopropargílicos demonstrou que o eter de silício TIPS é útil como grupo régio-dirigente. A aplicação da metodologia na síntese de um fragmento do (±)-Seselidiol, um produto natural, demonstrou a aplicabilidade da metodologia desenvolvida.

The influence of protecting groups on the synthesis of regio- and stereodefined vinyl tellurides derived from the reaction of BuTeNa and propargylic- or homo-propargylic alcohols showed that TIPS silyl ether is useful as a regiodirecting group. The application of the methodology to the synthesis of a fragment of (±)-Seselidiol, a natural product, demonstrated the applicability of the new methodology.