Abstract The Amazonian forests of Peru are among the most diverse and disturbed by anthropic activities on the planet, today there are still gaps on the composition of the communities and their inter-specific relationships. A forest inventory was carried out in a terraced forest in the Madre de Dios region, 5 blocks were established with 2 rectangular plots of 20m x 500m each to identify and measure individuals with diameter greater than 10 cm. 4429 trees were evaluated and 254 species, 165 genera and 53 families were identified. The distribution of diameter classes and height presents typical patterns of intervened forests, in this case by the extraction of wood decades ago. The average of the biodiversity indices are: Shannon-Wienner 4.039 ± 0.16 and α-Fisher 39.90 ± 9.23, indicating that there is a high diversity of species. The species of greatest ecological importance were: Tetragastris altissima (Aubl.) Swart, Iriartea deltoidea Ruiz & Pav, Euterpe precatoria Mart., Which are fast growing and are present throughout the neo-tropics, Tachigali vasquezii Pipoly, abundant only in the forests of this region; These species took advantage of the opening of the canopy by felling and increased their abundance and dominance in the area. On the other hand, Ocotea bofo Kunth, Bertholletia excelsa Bonpl, Eschweilera coriácea (DC.) S.A. Mori, dominate the forest, but of low abundance, due to changes in the floristic composition after wood harvesting.

Resumen Los bosques amazónicos del Perú están entre los más diversos y disturbados por actividades antrópicas del planeta, hoy en día sigue habiendo vacíos sobre la composición de las comunidades y sus relaciones interespecíficas. Se realizó un inventario forestal en un bosque de terrazas en la región Madre de Dios, se establecieron 5 bloques con 2 parcelas rectangulares de 20m x 500m cada uno para identificar y medir los individuos con diámetro mayor a 10 cm. Se evaluaron 4429 árboles e identificaron 254 especies, 165 géneros y 53 familias. La distribución de clases diamétricas y altura presenta patrones típicos de bosques intervenidos, en este caso por la extracción de madera décadas atrás. El promedio de los índices de biodiversidad son: Shannon- Wienner 4.039 ± 0.16 y α-Fisher 39.90 ± 9.23, indicando que existe una alta diversidad de especies. Las especies de mayor importancia ecológica fueron: Tetragastris altissima (Aubl.) Swart, Iriartea deltoidea Ruiz & Pav, Euterpe precatoria Mart., las cuales son de rápido crecimiento y están presentes en todo el neo trópico, Tachigali vasquezii Pipoly, abundante solo en los bosques de esta región; estas especies aprovecharon la apertura de dosel por talas e incrementaron su abundancia y dominancia en el área. Por otra parte, Ocotea bofo Kunth, Bertholletia excelsa Bonpl, Eschweilera coriácea (DC.) S.A. Mori, dominan el bosque, pero de baja abundancia, debido a los cambios de la composición florística después del aprovechamiento de madera.

ABSTRACT The adherence to accreditation programs proves the institutions' voluntary effort to pursue the quality and safety of their products and services by meeting internationally accepted standards audited by experts in the field, external to the service. Meeting such standards often exceeds domestic legal requirements. However, service providers are not released from complying with the legal requirements, both local and international, pertinent to the field. Accreditation programs use the precepts of the quality management system to validate and standardize processes, monitor results through quality control, proficiency testing, and indicators, and perform risk management. For cellular therapy services, the assessing agencies available in our field are the AABB/ABHH (American Association of Blood Banks/Brazilian Association of Hematology, Hemotherapy and Cellular Therapy) and FACT-JACIE (Foundation for the Accreditation of Cellular Therapy-Joint Accreditation Committee, ISCT/EBMT). Both agencies require that the accredited organization meets all the standards defined in each program. Applying services also have to establish and comply with a quality management standard that demonstrates procedural interrelationship to ensure product and service quality. This paper aims to concisely outline the essential features of those two accreditation programs, along with a brief overview of the accreditation process under each of them.

ABSTRACT Chimeric antigen receptor T cells (CAR-T), especially against CD19 marker, present in lymphomas and acute B leukemia, enabled a revolution in the treatment of hematologic neoplastic diseases. The manufacture of CAR-T cells requires the adoption of GMP-compatible methods and it demands the collection of mononuclear cells from the patient (or from the donor), generally through the apheresis procedure, T cell selection, activation, transduction and expansion ex vivo, and finally storage, usually cryopreserved, until the moment of their use. An important aspect is the quality control testing of the final product, for example, the characterization of its identity and purity, tests to detect any contamination by microorganisms (bacteria, fungi, and mycoplasma) and its potency. The product thawing and intravenous infusion do not differ much from what is established for the hematopoietic progenitor cell product. After infusion, it is important to check for the presence and concentration of CAR-T cells in the patient’s peripheral blood, as well as to monitor their clinical impact, for instance, the occurrence of short-term, such as cytokine release syndrome and neurological complications, and long-term complications, which require patient follow-up for many years.