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ABSTRACT: The present study described the prevalence and factors associated with the seropositivity for anti-Brucella spp. antibodies in working equids in the semiarid regionofnortheastern Brazil. Blood samples were collected from 322 equids (76 horses, 155 mules and 91 donkeys). The Rose Bengal plate test (RBPT) was used as a screening method. Samples that were reactive in the RBPT were tested for confirmation using 2-mercaptoethanol (2-ME) and the standard tube agglutination test (STAT). Overall, 7.1% (23/322) of the samples were positive according to the RBPT. After confirmatory tests, the prevalence of brucellosis was found to be 6.5% (21/322). Among these cases, 33.3% (7/21) were horses, 42.8% (9/21) were mules and 23.9% (5/21) were donkeys. In the multivariate analysis, age over 10 years was considered to be a factor associated with the seropositivity (OR: 17.17; 95% CI: 2.582-164.7, P = 0.006) for anti-Brucella spp. antibodies. The significant prevalence of anti-Brucella spp. antibodies found in working equids and the wide distribution of positive animals demonstrates a worrying epidemiological situation regarding brucellosis in the study region. Age over 10 years was a risk factor associated with the seropositivity for anti-Brucella spp. antibodies in animals. ABSTRACT antiBrucella anti Brucella spp Brazil 32 76 (7 horses 15 9 donkeys . donkeys) (RBPT method 2mercaptoethanol mercaptoethanol 2 2ME ME (2-ME STAT. STAT (STAT) Overall 71 7 1 7.1 23/322 23322 23 (23/322 tests 65 6 5 6.5 21/322. 21322 21/322 21 (21/322) cases 333 33 3 33.3 7/21 721 (7/21 428 42 8 42.8 9/21 921 (9/21 239 23.9 5/21 521 (5/21 analysis OR (OR 17.17 1717 17 95 CI 2.582164.7, 25821647 2.582 164.7, 582 164 2.582-164.7 0.006 0006 0 006 region ( (STAT 7. 23/32 2332 (23/32 6. 2132 21/32 (21/322 33. 7/2 72 (7/2 4 42. 9/2 92 (9/2 23. 5/2 52 (5/2 17.1 171 582164 2.582164.7 2582164 2582 2.58 1647 164.7 58 16 2.582-164. 0.00 000 00 23/3 233 (23/3 213 21/3 (21/32 7/ (7/ 9/ (9/ 5/ (5/ 17. 58216 2.582164. 258216 258 2.5 164. 2.582-164 0.0 23/ (23/ 21/ (21/3 (9 (5 5821 2.582164 25821 25 2. 2.582-16 0. (23 (21/ 2.58216 2.582-1 (2 (21 2.5821 2.582-

RESUMO: O objetivo do presente estudo foi descrever a prevalência e os fatores associados à infecção por Brucellaspp. em equídeos de trabalho na região semiárida do Nordeste do Brasil. Amostras de sangue foram coletadas de 322 equídeos (76 equinos, 155 muares e 91 asininos). O teste de placa Rosa Bengala (RBPT) foi usado como método de triagem. As amostras que foram reativas no RBPT foram enviadas para confirmação usando 2-mercaptoetanol (2-ME) e o teste padrão de aglutinação em tubo (STAT). Ao todo, 7,1% (23/322) das amostras foram positivas segundo o RBPT. Após testes confirmatórios, a prevalência de brucelose foi de 6,5% (21/322). Destes casos, 33,3% (7/21) foram equinos, 42,8% (9/21) muares e 23,9% (5/21) asininos. Na análise multivariada, idade acima de 10 anos foi considerada fator associado à infecção (OR: 17,17; 95% CI: 2,582-164,7, P = 0.006) por Brucellas pp. A prevalência significativa de anticorpos anti-Brucella spp. encontrados em equídeos de trabalho e a ampla distribuição de animais positivos demonstra uma situação epidemiológica preocupante em relação à brucelose na região de estudo. A idade superior a 10 anos foi um fator de risco associado à infecção em animais. RESUMO Brucellaspp Brasil 32 76 (7 equinos 15 9 asininos . asininos) (RBPT triagem 2mercaptoetanol mercaptoetanol 2 2ME ME (2-ME STAT. STAT (STAT) todo 71 7 1 7,1 23/322 23322 23 (23/322 confirmatórios 65 6 5 6,5 21/322. 21322 21/322 21 (21/322) casos 333 33 3 33,3 7/21 721 (7/21 428 42 8 42,8 9/21 921 (9/21 239 23,9 5/21 521 (5/21 multivariada OR (OR 17,17 1717 17 95 CI 2,582164,7, 25821647 2,582 164,7, 582 164 2,582-164,7 0.006 0006 0 006 pp antiBrucella anti Brucella spp ( (STAT 7, 23/32 2332 (23/32 6, 2132 21/32 (21/322 33, 7/2 72 (7/2 4 42, 9/2 92 (9/2 23, 5/2 52 (5/2 17,1 171 582164 2,582164,7 2582164 2582 2,58 1647 164,7 58 16 2,582-164, 0.00 000 00 23/3 233 (23/3 213 21/3 (21/32 7/ (7/ 9/ (9/ 5/ (5/ 17, 58216 2,582164, 258216 258 2,5 164, 2,582-164 0.0 23/ (23/ 21/ (21/3 (9 (5 5821 2,582164 25821 25 2, 2,582-16 0. (23 (21/ 2,58216 2,582-1 (2 (21 2,5821 2,582-

https://doi.org/10.1590/0103-8478cr20220648

Mapping Rainfall Variability in the São Francisco River Basin: Insights for Water Resource Management Basin
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Medeiros, Elias Silva de

; Oliveira, Willian dos Santos

; Silva, Paulo Vinicius da

; Souza, Amaury de

; Bicalho, Carolina Cristina

; Mauad, Munir

; Souza, Sidnei Azevedo de

Revista Brasileira de Meteorologia

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2024, Volume 39 elocation e39240050

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The São Francisco River Basin (SFRB) is extremely important for both the local rural and urban population, running through several states and municipalities in Brazil. Thus, the study of the spatial distribution of rainfall in the SFRB, supported by the application of geostatistics, offers valuable insights for water management and planning. In this study, data from 341 rainfall stations were used, corresponding to the period between 1989 and 2018, and monthly accumulated rainfall analyzed. About the trends, positive estimates for latitude, except for April, highlight that the accumulated precipitation decreases from south to north each month. In December, 85.10% of the spatial variability of rainfall was explained by the trend of rainfall concerning geographical coordinates. Concerning spatial dependence, the analyzed data predominantly exhibited the exponential variogram model. The conducted analyses offered a holistic view of rainfall in the region, facilitating the understanding of spatial patterns and shedding light on challenges in the face of climate change. Our research limited on the spatial modeling of rainfall in the SFRB, and future work should include modeling socio-economic and environmental impacts in the region concerning the spatial irregularity of rainfall. SFRB (SFRB population Brazil Thus geostatistics planning 34 used 198 2018 trends latitude April month December 8510 85 10 85.10 coordinates dependence model change socioeconomic socio economic 3 19 201 851 8 1 85.1 20 85. 2

Resumo A Bacia Hidrográfica do Rio São Francisco (SFRB) é de extrema importância tanto para a população rural quanto urbana local, percorrendo diversos estados e municípios do Brasil. O estudo da distribuição espacial das chuvas na SFRB, apoiado na aplicação da geoestatística, oferece insights valiosos para a gestão e planejamento hídrico. Nesse estudo foram utilizados dados de 341 estações pluviométricas, correspondentes ao período entre 1989 e 2018, e analisadas as chuvas acumuladas mensais. Sobre a tendência, estimativas positivas para a latitude, com exceção de abril, ressaltam que a precipitação acumulada em cada mês diminui de sul para norte. No mês de dezembro, 85,10% da variabilidade espacial das chuvas foi explicada pela tendência das chuvas em relação às coordenadas geográficas. Na dependência espacial, os dados analisados mostram predomínio do modelo de variograma exponencial. As análises realizadas proporcionaram uma visão holística das chuvas na região, permitindo a compreensão dos padrões espaciais e lançando luz sobre os desafios apresentados em um cenário de mudanças climáticas. Essa pesquisa limitou-se à modelagem espacial das chuvas na SFRB, e uma modelagem dos impactos socioeconômicos e ambientais na região em relação à irregularidade espacial das chuvas é essencial para trabalhos futuros. SFRB (SFRB local Brasil geoestatística hídrico 34 pluviométricas 198 2018 mensais latitude abril norte dezembro 8510 85 10 85,10 geográficas exponencial climáticas limitouse limitou se futuros 3 19 201 851 8 1 85,1 20 85, 2

https://doi.org/10.1590/0102-77863910050

Assessing bone mineral density in children and adolescents living with HIV and on treatment with tenofovir disoproxil fumarate: a systematic review fumarate
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Gusmão, Maria Brennda Ferreira de

; Oliveira, Vinícius Vital de

; Santos, Natália Maria da Silva

; Melo, Luciana Costa

Revista Paulista de Pediatria

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2024, Volume 42 elocation e2023042

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To investigate the impact of tenofovir disoproxil fumarate on bone mineral density and bone mineral content in children and adolescents infected with the human immunodeficiency virus. Data source: The search procedure was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement. The search was carried out until April 2022 in Medical Literature Analysis and Retrieval System Online (Medline), Embase, Cochrane Central, Latin American and Caribbean Health Sciences Literature, Web of Science, Scopus, and MedRxiv. The combination of terms used was: (Children OR Youth OR Teenagers) AND HIV AND (Tenofovir OR “Antiretroviral therapy”) AND (“Bone density” OR Osteoporosis OR Osteopenia). The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO, CRD42022312851) Data synthesis: The initial searches resulted in 1156 papers. After the exclusion of duplicate studies, three blinded reviewers analyzed the title and abstract of 563 papers, of which 57 remained to be read in full. Only nine papers met the eligibility criteria and were included in descriptive and risk-of-bias analyses. Regarding study design, four were cross-sectional, three were longitudinal before-after studies without a control group, and two were prospective cohorts. Among these nine papers, seven showed no significant association between tenofovir disoproxil fumarate use and reduced bone mass in young people. However, these papers did not have high methodological quality. Conclusions: Although most of the selected papers found no harmful effect of tenofovir disoproxil fumarate on bone mass, further primary research with higher methodological quality is needed so robust scientific evidences can be obtained. Objective virus source MetaAnalyses Meta Analyses Statement 202 Medline, Medline , (Medline) Embase Central Science Scopus MedRxiv Children Teenagers Tenofovir Antiretroviral therapy therapy” Bone Osteopenia. Osteopenia . Osteopenia) PROSPERO, PROSPERO (PROSPERO CRD42022312851 CRD synthesis 115 56 5 full riskofbias risk bias analyses design crosssectional, crosssectional cross sectional, sectional cross-sectional beforeafter before after group cohorts people However Conclusions obtained 20 (Medline CRD4202231285 11 2 CRD420223128 1 CRD42022312 CRD4202231 CRD420223 CRD42022 CRD4202 CRD420 CRD42 CRD4

RESUMO Objetivo: Investigar o impacto do tenofovir disoproxil fumarato sobre a densidade mineral óssea e o conteúdo mineral ósseo em crianças e adolescentes infectados pelo vírus da imunodeficiência humana. Fontes de dados: O procedimento de busca foi executado de acordo com o Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. A busca foi realizada até abril de 2022 nas seguintes bases de dados: Medical Literature Analysis and Retrieval System Online (Medline), Embase, Cochrane Central, Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs), Web of Science, Scopus, and MedRxiv. A combinação de termos utilizada foi: (Children OR Youth OR Teenagers) AND HIV AND (Tenofovir OR “Antiretroviral therapy”) AND (“Bone density” OR Osteoporosis OR Osteopenia). O protocolo foi registrado na base International Prospective Register of Systematic Reviews — PROSPERO (CRD42022312851). Síntese dos dados: As pesquisas iniciais resultaram em 1.156 artigos. Após a exclusão dos estudos duplicados, três revisores cegos analisaram título e resumo de 563 estudos, dos quais 57 permaneceram para leitura na íntegra. Somente nove artigos atenderam aos critérios de elegibilidade e foram incluídos para análises descritivas e de risco de viés. Com relação ao desenho dos estudos, quatro foram transversais, três foram estudos longitudinais antes-depois sem grupo controle e dois foram coortes prospectivas. Dos nove artigos, sete não mostraram associação significativa entre uso de TDF e redução de massa óssea em pessoas jovens. Entretanto, esses estudos não tiveram alta qualidade metodológica. Conclusões: Embora a maioria dos estudos selecionados não tenha encontrado efeito prejudicial do TDF sobre massa óssea, novas pesquisas primárias com maior qualidade metodológica são necessárias para que sejam obtidas evidências científicas robustas. Objetivo humana dados MetaAnalyses Meta Analyses PRISMA (PRISMA Statement 202 Medline, Medline , (Medline) Embase Central LatinoAmericana Latino Americana Lilacs, Lilacs (Lilacs) Science Scopus MedRxiv Children Teenagers Tenofovir Antiretroviral therapy therapy” Bone density Osteopenia. Osteopenia . Osteopenia) CRD42022312851. CRD42022312851 CRD (CRD42022312851) 1156 1 156 1.15 duplicados 56 5 íntegra viés transversais antesdepois antes depois prospectivas jovens Entretanto Conclusões robustas 20 (Medline (Lilacs CRD4202231285 (CRD42022312851 115 15 1.1 2 CRD420223128 (CRD4202231285 11 1. CRD42022312 (CRD420223128 CRD4202231 (CRD42022312 CRD420223 (CRD4202231 CRD42022 (CRD420223 CRD4202 (CRD42022 CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

https://doi.org/10.1590/1984-0462/2024/42/2023042

Diretrizes Brasileiras de Medidas da Pressão Arterial Dentro e Fora do Consultório – 2023 202 20 2
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Feitosa, Audes Diogenes de Magalhães

; Barroso, Weimar Kunz Sebba

; Mion Junior, Decio

; Nobre, Fernando

; Mota-Gomes, Marco Antonio

; Jardim, Paulo Cesar Brandão Veiga

; Amodeo, Celso

; Oliveira, Adriana Camargo

; Alessi, Alexandre

; Sousa, Ana Luiza Lima

; Brandão, Andréa Araujo

; Pio-Abreu, Andrea

; Sposito, Andrei C.

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Rodrigues, Cibele Isaac Saad

; Forjaz, Claudia Lucia de Moraes

; Sampaio, Diogo Pereira Santos

; Barbosa, Eduardo Costa Duarte

; Freitas, Elizabete Viana de

; Cestario, Elizabeth do Espirito Santo

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Feitosa, Fabiana Gomes Aragão Magalhães

; Consolim-Colombo, Fernanda Marciano

; Almeida, Fernando Antônio de

; Silva, Giovanio Vieira da

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Guimarães, Isabel Cristina Britto

; Gemelli, João Roberto

; Barreto-Filho, José Augusto Soares

; Vilela-Martin, José Fernando

; Ribeiro, José Marcio

; Yugar-Toledo, Juan Carlos

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano F.

; Bortolotto, Luiz Aparecido

; Alves, Marco Antonio de Melo

; Malachias, Marcus Vinícius Bolívar

; Neves, Mario Fritsch Toros

; Santos, Mayara Cedrim

; Dinamarco, Nelson

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Vitorino, Priscila Valverde de Oliveira

; Miranda, Roberto Dischinger

; Bezerra, Rodrigo

; Pedrosa, Rodrigo Pinto

; Paula, Rogerio Baumgratz de

; Okawa, Rogério Toshiro Passos

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C.

; Lima, Sandro Gonçalves de

; Inuzuka, Sayuri

; Ferreira-Filho, Sebastião Rodrigues

; Fillho, Silvio Hock de Paffer

; Jardim, Thiago de Souza Veiga

; Guimarães Neto, Vanildo da Silva

; Koch, Vera Hermina Kalika

; Gusmão, Waléria Dantas Pereira

; Oigman, Wille

; Nadruz Junior, Wilson

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 4 elocation e20240113

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20240113

Acute renal failure, COVID-19 and deaths, worrying rates in intensive care units: a cross-sectional study failure COVID19 COVID 19 COVID-1 deaths units crosssectional cross sectional COVID1 1 COVID-
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Watanabe, Yoshimi José Ávila

; Carvalho, Lívia Maria Rezende

; Guedes, João Victor Marques

; Baldoni, André Oliveira

; Belo, Vinícius Silva

; Otoni, Alba

Sao Paulo Medical Journal

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2024, Volume 142 Nº 6 elocation e2023150

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Acute kidney failure is a serious consequence of coronavirus disease 2019 (COVID-19). OBJECTIVES: To identify the prevalence of COVID-19, kidney failure, frequency of death, and associated factors in patients receiving intensive care. DESIGN AND SETTING: Analytical cross-sectional study conducted in the intensive care unit (ICU) of a medium-sized philanthropic general hospital in center-west Minas Gerais. METHODS: Adults and older individuals who underwent real-time polymerase chain reaction testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were evaluated by the nephrology team. RESULTS: Among the 176 patients, the prevalence of COVID-19 and acute kidney injury (AKI) were 103 (58.5%) and 132 (75%), respectively, and 44 (25%) had chronic kidney disease (CKD) and 16 (15,5%) were positive for SARS-CoV-2. In the Charlson index classification, which estimates the risk of death, a statistically significant difference was identified in the percentages of groups with and without COVID-19 for indices 0, 1, and 2. There was a significant association between kidney disease and ICU mortality (P < 0.05). Patients with CKD had fewer fatal outcomes (13/97, 13.4%) than those with AKI (85/97, 87.6%). CONCLUSIONS: COVID-19 rates remained high long after diagnosis and prevention of SARS-CoV-2 infection. In addition, a higher death rate among patients who developed AKI, whose prevalence was also greater than that in the national literature, regardless of the presence of COVID-19, revealed a worrying scenario and corroborated the need for early and judicious approaches to preserve the lives of patients with AKI admitted to intensive care units. BACKGROUND 201 COVID19. COVID19 COVID 19 . (COVID-19) OBJECTIVES COVID19, 19, SETTING crosssectional cross sectional (ICU mediumsized medium sized centerwest center west Gerais METHODS realtime real time SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 team RESULTS 17 COVID-1 (AKI 10 58.5% 585 58 5 (58.5% 13 75%, 75 75% , (75%) respectively 4 25% 25 (25% (CKD 1 15,5% 155 15 (15,5% SARSCoV2. classification 0 P 0.05. 005 0.05 05 0.05) 13/97, 1397 97 (13/97 13.4% 134 85/97, 8597 85 (85/97 87.6%. 876 87.6% 87 6 87.6%) CONCLUSIONS SARS-CoV- infection addition literature units 20 COVID1 (COVID-19 (SARS-CoV- COVID- 58.5 (58.5 7 (75% (25 15,5 (15,5 00 0.0 13/97 139 9 (13/9 13.4 85/97 859 8 (85/9 87.6 SARS-CoV (COVID-1 (SARS-CoV 58. (58. (75 (2 15, (15, 0. 13/9 (13/ 13. 85/9 (85/ 87. (COVID- (58 (7 ( (15 13/ (13 85/ (85 (COVID (5 (1 (8

https://doi.org/10.1590/1516-3180.2023.0150.r1.13052024

Influence of Teas on Phospholipase A2 and Protease Activity in the Context of Blood Hemostasis-Related Processes A HemostasisRelated Hemostasis Related
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Carapiá, Mateus Santos

; Oliveira, Daniela Aparecida

; Trento, Marcus Vinicius Cardoso

; Marcussi, Silvana

; Abreu, Tatiane Silva de

; Cesar, Pedro Henrique Souza

; Braga, Mariana Aparecida

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24220661

Resumo: En | Texto: En | PDF: En

Abstract Tea is identified as the second most consumed drink in the world, and its frequent intake is related to several benefits to human health, considering its antimutagenic, anticarcinogenic, antimicrobial, anti-inflammatory, antihistamine, diuretic, calming, and above all, antioxidant effects. These effects are often associated with the action of the phenolic compounds contained in these infusions. In Brazil, among the most consumed infusions are the teas of chamomile (Matricaria chamomilla L.), lemongrass (Cymbopogon citratus (D.C.) Stapf), lemon balm (Melissa officinalis L.), anise (Pimpinella anisum L.), yerba mate (Ilex paraguariensis A. St.-Hil), peppermint (Mentha piperita L.), and green/black tea (Camellia sinensis L.). Therefore, said popularity is the reason why the mentioned species were chosen to be evaluated on inflammatory enzymes. The activity of phospholipases A2 was reduced by more than 25% after treatment with black tea and yerba mate. The most significant inhibition of protease activity was observed after incubation with black tea (40.74%), green tea (31.48%) and yerba mate (25.93%). Infusions of black and green tea reduced hemolysis in semisolid and liquid media, and for the latter, reductions of up to 50% of hemolytic activity were observed, indicating an anti-inflammatory potential of the samples. Plasma incubations with green tea, black tea and lemon balm and subsequent addition of venom (1:10 ratio; tea:PBS, v:v) prolonged the coagulation time of citrated plasma by approximately twice compared to the positive control. All controls with pure tea had a thrombolytic character, in higher proportions than the venom control, especially chamomile (273.55% dissolution). Phenolic compounds derived from phenolic acids, flavonoids, and tannins are identified as the main agents that promote the biological effects observed in this study. This is mainly due to their anti-catalytic properties exerted on inflammatory enzymes and as chelating agents of enzymatic co-factors. The evaluated teas showed potential for nutraceutical use, thus pointing to the possibility of use as an adjuvant in the treatment of diseases linked to hemostasis. world health antimutagenic anticarcinogenic antimicrobial antiinflammatory, antiinflammatory anti inflammatory, antihistamine diuretic calming all Brazil Matricaria L., L L. , L.) Cymbopogon D.C. DC D C (D.C. Stapf, Stapf Stapf) Melissa Pimpinella Ilex A St.Hil, StHil St. Hil St St.-Hil) Mentha greenblack Camellia L.. . Therefore 25 40.74%, 4074 40.74% 40 74 (40.74%) 31.48% 3148 31 48 (31.48% 25.93%. 2593 25.93% 93 (25.93%) media latter 50 samples 110 1 10 (1:1 ratio teaPBS, teaPBS PBS, PBS tea:PBS vv v v:v control character 273.55% 27355 273 55 (273.55 dissolution. dissolution dissolution) acids flavonoids study anticatalytic catalytic cofactors. cofactors co factors. factors co-factors hemostasis D.C (D.C St.Hil St.-Hil 2 407 40.74 4 7 (40.74% 31.48 314 3 (31.48 259 25.93 9 (25.93% 5 11 (1: 273.55 2735 27 (273.5 40.7 (40.74 31.4 (31.4 25.9 (25.93 (1 273.5 (273. 40. (40.7 31. (31. 25. (25.9 ( 273. (273 (40. (31 (25. (27 (40 (3 (25 (2 (4

https://doi.org/10.1590/1678-4324-2024220661

Searching for common bean genotypes resistant to Acanthoscelides obtectus, a primary pest species of stored beans obtectus
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Cabral, Isabella Rubio

; Baldin, Edson Luiz Lopes

; Faria, Rodrigo Donizeti

; Silva, Jamilly Pereira

; Santos, Thais Lohaine Braga dos

; Takaku, Vinicius Seiji de Oliveira

; Santana, Alisson da Silva

; Lima, Ana Paula Santana

; Canassa, Vinicius Fernandes

; Ribeiro, Leandro do Prado

Bragantia

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2024, Volume 83 elocation e20230173

Resumo: En | Texto: En | PDF: En

ABSTRACT Resistant genotypes are a valuable tool in integrated pest management programs of insect pests of stored grains. Here, we screened 90 Brazilian common bean genotypes to select promising sources of resistance to Acanthoscelides obtectus. Thus, bean samples were infested with newly emerged insects, and the number of eggs, emerged insects, developmental time, and larval viability were assessed in a no-choice test. Genotypes IPR Garça, CHIR 13, IAC Harmonia, CHIR 20, IAC Boreal, and CHIP 312 showed low oviposition. Genotypes IPR Quero-Quero, BRS Notável, CHIC 61 - Cariocão, BRS Ametista, IPR Uirapuru, IAC Imperador, Avaluna, CHP 04-241A-212 - Guapo B. × Uirapuru, CHIB 06, SCS 206 - Potência, CHC 01-175-1 - Campeiro × IAC Tibatã, CHP 01-182-48 - Uirapuru × Campeiro, UEM 266, CHC 04-233-2 - Siriri × Horizonte, CHV 17-64, SCS 205 - Riqueza, CHP 01-238-80 - MN 13337, SM 1510 - preto, BRS Radiante, CHIB 18, CHIR 14, CAV 17 EFM 008, CHIR 04, IPR Campos Gerais, CHV 05-268-02, LP 13-624 - preto, Linhagem 110 - IAC, CHP 01-182-12 - Uirapuru × Campeiro, LP 13-84 - carioca, BRS Esteio, CHV 17-635, CHB 15-518, Arcelina 1, IPR Tuiuiu, SCS 204 - Predileto, TB - 17-02, BRS Estilo, SM 0511 - cavalo preto, Pérola, IPR Tangará, and CNFRj - 15411 reduced oviposition, the number of emerged adults, and larval viability, suggesting antixenosis and/or antibiosis. Thus, these genotypes are promising sources of resistance factors and can be used in breeding programs to obtain lines of common beans resistant to A. obtectus. grains Here 9 obtectus Thus insects eggs time nochoice no choice test Garça 13 Harmonia 20 Boreal 31 oviposition QueroQuero, QueroQuero Quero Quero, Quero-Quero Notável 6 Cariocão Ametista Imperador Avaluna 04241A212 A 04 241A 212 04-241A-21 B 06 Potência 011751 01 175 1 01-175- Tibatã 0118248 182 48 01-182-4 266 042332 233 2 04-233- Horizonte 1764, 1764 64, 64 17-64 Riqueza 0123880 238 80 01-238-8 13337 151 preto Radiante 18 14 008 Gerais 0526802, 0526802 05 268 02, 02 05-268-02 13624 624 13-62 11 0118212 12 01-182-1 1384 84 13-8 carioca Esteio 17635, 17635 635, 635 17-635 15518, 15518 15 518, 518 15-518 Tuiuiu Predileto 1702, 1702 17-02 Estilo 051 Pérola Tangará 1541 adults andor or antibiosis 3 04241A21 0 21 04-241A-2 01175 01-175 011824 4 01-182- 26 04233 23 04-233 176 17-6 012388 8 01-238- 1333 00 052680 05-268-0 1362 62 13-6 011821 138 13- 1763 63 17-63 1551 51 15-51 170 17-0 154 04241A2 04-241A- 0117 01-17 01182 01-182 0423 04-23 17- 01238 01-238 133 05268 05-268- 136 155 5 15-5 04241A 04-241A 011 01-1 0118 01-18 042 04-2 0123 01-23 0526 05-268 15- 01- 04- 012 01-2 052 05-26 05-2 05-

https://doi.org/10.1590/1678-4499.20230173

Detection of gestational and congenital syphilis in Paraná state, Brazil, 2007-2021: a time series analysis state Brazil 20072021 2007 2021 2007-2021 2007202 200 202 2007-202 200720 20 2007-20 20072 2 2007-2 2007-
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Oliveira, Giovana Gomes de

; Palmieri, Isadora Gabriella Silva

; Lima, Lucas Vinícius de

; Pavinati, Gabriel

; Santos, Vitória Maytana Alves dos

; Luz, Kelly Cristina Suzue Iamaguchi

; Magnabosco, Gabriela Tavares

Epidemiologia e Serviços de Saúde

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2024, Volume 33 elocation e2024188

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Objetivo: Describir las tendencias temporales en las tasas de detección de sífilis gestacional y congénita, por grupo de edad materna y macrorregión de salud de Paraná, 2007-2021. Métodos: Estudio de series temporales utilizando datos de vigilancia; se realizó análisis de tendencia mediante regresión segmentada, estimando cambios porcentuales anuales promedio (CPAP) e intervalos de confianza del 95% (IC95%). Resultados: Se identificaron aumentos en la detección estatal de sífilis gestacional (CPAP = 21,7; IC95% 17,7;32,8) y congénita (CPAP = 14,8; IC95% 13,0;19,7); las macrorregiones mostraron incrementos, destacándose la Noroeste (gestacional, CPAP = 26,1; IC95% 23,4;31,6) y la Norte (congénita, CPAP = 23,8; IC95% 18,8;48,9); las tendencias estatales fueron crecientes para mujeres jóvenes [gestacional, CPAP = 26,2 (IC95% 22,4;40,6); congénita, CPAP = 19,4 (IC95% 17,6;21,8)] y adultas [gestacional, CPAP = 21,3 (IC95% 16,9;31,9); congénita, CPAP = 13,7 (IC95% 11,9;19,3)]. Conclusión: Las tasas de detección de sífilis materno-infantil estuvieron en aumento en el estado, independientemente de la edad materna y la macrorregión de salud. Objetivo Paraná 20072021. 20072021 2007 2021. 2021 2007-2021 Métodos vigilancia segmentada 95 IC95%. IC95 IC . (IC95%) Resultados 21,7 217 21 7 17,732,8 177328 17,7 32,8 17 32 8 17,7;32,8 14,8 148 14 13,019,7 130197 13,0 19,7 13 0 19 13,0;19,7) incrementos gestacional, (gestacional 26,1 261 26 1 23,431,6 234316 23,4 31,6 23 4 31 6 23,4;31,6 (congénita 23,8 238 18,848,9 188489 18,8 48,9 18 48 9 18,8;48,9) [gestacional 262 2 26, (IC95 22,440,6 224406 22,4 40,6 22 40 22,4;40,6) 194 19, 17,621,8 176218 17,6 21,8 17,6;21,8) 213 3 21, 16,931,9 169319 16,9 31,9 16 16,9;31,9) 137 13, 11,919,3. 119193 11,9 19,3 11 11,9;19,3)] Conclusión maternoinfantil materno infantil estado 2007202 200 202 2007-202 IC9 732 17,732, 17732 177 17, 328 32, 17,7;32, 14, 019 13,019, 13019 130 197 13,0;19,7 431 23,431, 23431 234 23, 316 31, 23,4;31, 848 18,848, 18848 188 18, 489 48, 18,8;48,9 (IC9 440 22,440, 22440 224 22, 406 40, 22,4;40,6 621 17,621, 17621 176 218 17,6;21,8 931 16,931, 16931 169 16, 319 16,9;31,9 919 11,919,3 11919 119 11, 193 11,9;19,3) 200720 20 2007-20 73 17,732 1773 17,7;32 01 13,019 1301 13,0;19, 43 23,431 2343 23,4;31 84 18,848 1884 18,8;48, (IC 44 22,440 2244 22,4;40, 62 17,621 1762 17,6;21, 93 16,931 1693 16,9;31, 91 11,919, 1191 11,9;19,3 20072 2007-2 17,73 17,7;3 13,01 13,0;19 23,43 23,4;3 18,84 18,8;48 22,44 22,4;40 17,62 17,6;21 16,93 16,9;31 11,919 11,9;19, 2007- 17,7; 13,0;1 23,4; 18,8;4 22,4;4 17,6;2 16,9;3 11,91 11,9;19 13,0; 18,8; 22,4; 17,6; 16,9; 11,9;1 11,9;

Abstract Objective: To describe temporal trends in the detection rates of gestational and congenital syphilis, by maternal age and health macro-region of the state of Paraná, Brazil, 2007-2021. Methods: This was a time-series study using surveillance data; the trend analysis was performed by means of joinpoint regression, and average annual percent change (AAPC) and 95% confidence intervals (95%CI) were estimated. Results: An increase in statewide detection of gestational syphilis (AAPC = 21.7; 95%CI 17.7; 32.8) and congenital syphilis (AAPC = 14.8; 95%CI 13.0; 19.7) was found; an increase was also found in the health macro-regions, with the Northwest (gestational, AAPC = 26.1; 95%CI 23.4; 31.6) and North (congenital, AAPC = 23.8; 95%CI 18.8; 48.9) macro-regions standing out; statewide rising trends were observed for young women [gestational, AAPC = 26.2 (95%CI 22.4; 40.6); congenital, AAPC = 19.4 (95%CI 17.6; 21.8)] and adult women [gestational, AAPC = 21.3 (95%CI 16.9; 31.9); congenital, AAPC = 13.7 (95%CI 11.9; 19.3)]. Conclusion: Maternal and child syphilis detection rates increased in the state, regardless of maternal age and health macro-region. Objective macroregion macro region Paraná Brazil 20072021. 20072021 2007 2021. 2021 2007-2021 Methods timeseries time series data regression 95 95CI CI estimated Results 21.7 217 21 7 17.7 177 17 32.8 328 32 8 14.8 148 14 13.0 130 13 0 19.7 197 19 macroregions, macroregions regions, regions gestational, (gestational 26.1 261 26 1 23.4 234 23 4 31.6 316 31 6 (congenital 23.8 238 18.8 188 18 48.9 489 48 9 out [gestational 262 2 26. 22.4 224 22 40.6 406 40 40.6) 194 19. 17.6 176 21.8 218 21.8) 213 3 21. 16.9 169 16 31.9 319 31.9) 137 13. 11.9 119 11 19.3. 193 19.3 . 19.3)] Conclusion macroregion. region. 2007202 200 202 2007-202 17. 32. 14. 23. 31. 18. 48. 22. 40. 16. 11. 19.3) 200720 20 2007-20 20072 2007-2 2007-

Resumo Objetivo: Descrever as tendências temporais nas taxas de detecção de sífilis gestacional e congênita, por faixa etária materna e macrorregião de saúde do Paraná, Brasil, 2007-2021. Métodos: Estudo de séries temporais, utilizando-se dados de vigilância; realizou-se análise de tendência por regressão segmentada, sendo estimadas variações percentuais anuais médias (VPAM) e intervalos de confiança de 95% (IC95%). Resultados: Foram identificados acréscimos na detecção estadual de sífilis gestacional (VPAM = 21,7; IC95% 17,7;32,8) e congênita (VPAM = 14,8; IC95% 13,0;19,7); as macrorregiões de saúde registraram incrementos, destacando-se as macrorregiões Noroeste (gestacional, VPAM = 26,1; IC95% 23,4;31,6) e Norte (congênita, VPAM = 23,8; IC95% 18,8;48,9); as tendências estaduais foram crescentes para mulheres jovens [gestacional, VPAM = 26,2 (IC95% 22,4;40,6); congênita, VPAM = 19,4 (IC95% 17,6;21,8)] e mulheres adultas [gestacional, VPAM = 21,3 (IC95% 16,9;31,9); congênita, VPAM = 13,7 (IC95% 11,9;19,3)]. Conclusão: As taxas de detecção de sífilis materno-infantil foram ascendentes no estado, independentemente da idade materna e da macrorregião de saúde. Objetivo Paraná Brasil 20072021. 20072021 2007 2021. 2021 2007-2021 Métodos utilizandose utilizando se vigilância realizouse realizou segmentada 95 IC95%. IC95 IC . (IC95%) Resultados 21,7 217 21 7 17,732,8 177328 17,7 32,8 17 32 8 17,7;32,8 14,8 148 14 13,019,7 130197 13,0 19,7 13 0 19 13,0;19,7) incrementos destacandose destacando gestacional, (gestacional 26,1 261 26 1 23,431,6 234316 23,4 31,6 23 4 31 6 23,4;31,6 (congênita 23,8 238 18,848,9 188489 18,8 48,9 18 48 9 18,8;48,9) [gestacional 262 2 26, (IC95 22,440,6 224406 22,4 40,6 22 40 22,4;40,6) 194 19, 17,621,8 176218 17,6 21,8 17,6;21,8) 213 3 21, 16,931,9 169319 16,9 31,9 16 16,9;31,9) 137 13, 11,919,3. 119193 11,9 19,3 11 11,9;19,3)] Conclusão maternoinfantil materno infantil estado 2007202 200 202 2007-202 IC9 732 17,732, 17732 177 17, 328 32, 17,7;32, 14, 019 13,019, 13019 130 197 13,0;19,7 431 23,431, 23431 234 23, 316 31, 23,4;31, 848 18,848, 18848 188 18, 489 48, 18,8;48,9 (IC9 440 22,440, 22440 224 22, 406 40, 22,4;40,6 621 17,621, 17621 176 218 17,6;21,8 931 16,931, 16931 169 16, 319 16,9;31,9 919 11,919,3 11919 119 11, 193 11,9;19,3) 200720 20 2007-20 73 17,732 1773 17,7;32 01 13,019 1301 13,0;19, 43 23,431 2343 23,4;31 84 18,848 1884 18,8;48, (IC 44 22,440 2244 22,4;40, 62 17,621 1762 17,6;21, 93 16,931 1693 16,9;31, 91 11,919, 1191 11,9;19,3 20072 2007-2 17,73 17,7;3 13,01 13,0;19 23,43 23,4;3 18,84 18,8;48 22,44 22,4;40 17,62 17,6;21 16,93 16,9;31 11,919 11,9;19, 2007- 17,7; 13,0;1 23,4; 18,8;4 22,4;4 17,6;2 16,9;3 11,91 11,9;19 13,0; 18,8; 22,4; 17,6; 16,9; 11,9;1 11,9;

https://doi.org/10.1590/s2237-96222024v33e2024188.en

Challenges of Congenital Heart Surgery in Brazil: It is Time to Designate Pediatric Congenital Heart Surgery Subspecialty Brazil
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Pinto Júnior, Valdester Cavalcante

; Miana, Leonardo Augusto

; Navarro, Fábio Binhara

; Rocha, Bruno da Costa

; Assad, Renato Samy

; Oliveira, Marcos Aurélio Barboza de

; Salum, Fábio Said

; Croti, Ulisses Alexandre

; Furlanetto, Beatriz Helena Sanches

; Jatene, Marcelo Biscegli

; Caneo, Luiz Fernando

; Monteiro, Andrey José de Oliveira

; Moraes Neto, Fernando Ribeiro de

; Antoniali, Fernando

; Salerno, Pedro Rafael

; Nina, Vinicius José da Silva

Brazilian Journal of Cardiovascular Surgery

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2024, Volume 39 Nº 4 elocation e20240138

Resumo: En | Texto: En | PDF: En

ABSTRACT Congenital heart disease (CHD) affects eight to ten out of every 1,000 births, resulting in approximately 23,057 new cases in Brazil in 2022. About one in four children with CHD requires surgery or other procedures in the first year of life, and it is expected that approximately 81% of these children with CHD will survive until at least 35 years of age. Professionals choosing to specialize in CHD surgery face numerous challenges, not only related to mastering surgical techniques and the complexity of the diseases but also to the lack of recognition by medical societies as a separate subspecialty. Furthermore, families face difficulties when access to services capable of providing treatment for these children. To address these challenges, it is essential to have specialized hospitals, qualified professionals, updated technologies, sustainable industry, appropriate financing, quality assessment systems, and knowledge generation. The path to excellence involves specialization across all involved parties. As we reflect on the importance of Pediatric Cardiovascular Surgery and Congenital Heart Diseases establishing themselves as a subspecialty of Cardiovascular Surgery, it is essential to look beyond our borders to countries like the United States of America and United Kingdom, where this evolution is already a reality. This autonomy has led to significant advancements in research, education, and patient care outcomes, establishing a care model. By following this path in Brazil, we not only align our practice with the highest international standards but also demonstrate our maturity and the ability to meet the specific needs of patients with CHD and those with acquired childhood heart disease. (CHD 1000 1 000 1,00 births 23057 23 057 23,05 2022 life 81 3 age challenges Furthermore hospitals professionals technologies industry financing systems generation parties Kingdom reality research education outcomes model 100 00 1,0 2305 2 05 23,0 202 8 10 0 1, 230 23, 20

https://doi.org/10.21470/1678-9741-2024-0138

10.

PERFIL VOLÁTIL DO Coffea arabica E Coffea canephora var. conilon POR SHS-GC-MS E QUIMIOMETRIA var SHSGCMS SHS GC MS
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Lyrio, Marcos Valério Vieira

; Cunha, Pedro Henrique Pereira da

; Debona, Danieli Grancieri

; Agnoletti, Bárbara Zani

; Frinhani, Roberta Quintino

; Oliveira, Emanuele Catarina da Silva

; Filgueiras, Paulo Roberto

; Pereira, Lucas Louzada

; Castro, Eustáquio Vinicius Ribeiro de

Química Nova

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2024, Volume 47 Nº 5 elocation e-20230130

Resumo: Pt | Texto: Pt | PDF: Pt

The volatile composition of coffee exerts a substantial influence on its quality, as it defines the characteristics of the beverage. However, these compounds are influenced by factors within the coffee production chain, such as botanical origin, geography, processing methods, and roasting. Consequently, the identification of such compounds becomes a vital tool for characterizing coffees to these factors. In this context, gas chromatography with headspace extraction is widely used for aroma analysis, providing a composition closer to consumer perception. Headspace extraction offers speed, simplicity, minimal sample preparation, and no need for solvents. In this study, static headspace extraction (SHS) coupled with gas chromatography-mass spectrometry (SHS-GC-MS) was employed to establish the chemical profile of volatile compounds in Coffea arabica and Coffea canephora var. conilon and determine discriminants between the species. A total of 97 compounds, belonging to 17 chemical classes, were identified. The chemometric analysis highlighted furans, phenols, and carboxylic acids as key differentiating classes. Notably, furfuryl alcohol, acetic acid, 4-vinylguaiacol, N-acetyl-4(H)-pyridine, and N-furfurylpyrrole emerged as crucial volatile compounds. The variable selection using Fisher weight applied directly in the chromatograms, produced models consistent with relative area data, with furfuryl alcohol and 4-vinylguaiacol regions being particularly influential in differentiation. quality beverage However chain origin geography methods roasting Consequently context perception speed simplicity preparation solvents study SHS (SHS chromatographymass mass SHSGCMS GC MS (SHS-GC-MS var species 9 1 classes identified furans phenols Notably acid 4vinylguaiacol, 4vinylguaiacol vinylguaiacol 4 vinylguaiacol, Nacetyl4Hpyridine, Nacetyl4Hpyridine NacetylHpyridine N acetyl H pyridine, pyridine N-acetyl-4(H)-pyridine Nfurfurylpyrrole furfurylpyrrole chromatograms data differentiation Nacetyl Hpyridine

https://doi.org/10.21577/0100-4042.20230130

11.

Performance of Recombinant Nucleocapsid Protein-Based Constructs for Serological Diagnosis of SARS-CoV-2 Infection ProteinBased Protein Based SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- SARS-CoV
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Oliveira, Natasha Rodrigues de

; Santos, Francisco Denis Souza

; Seixas Neto, Amilton Clair Pinto

; Barbosa, Liana Nunes

; Bilhalva, Miguel Andrade

; Costa, Ana Vitória

; Donassolo, Rafael Amaral

; Rodrigues, Rafael Rodrigues

; Alves, Mariliana Luiza Ferreira

; Ferreira, Marcos Roberto Alves

; Moreira Júnior, Clóvis

; Lacerda, Marcus Vinícius Guimarães de

; Melo, Gisely Cardoso de

; Dellagostin, Odir Antônio

; McBride, Alan John Alexander

; Pinto, Luciano da Silva

; Moreira, Ângela Nunes

; Conceição, Fabrício Rochedo

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24230196

Resumo: En | Texto: En | PDF: En

Abstract Since the inception of COVID-19 pandemic, there has been a challenging race for the development of precise diagnostic tests. Specific SARS-CoV-2 serological assays are the main tools used to estimate the rate of past infections or herd immunity in epidemiological studies, in addition to being helpful in guiding public health management policies. In this study, an in-house ELISA based on the construct of SARS-CoV-2 nucleocapsid (N) proteins, named rCoV2, rCoV4, and rCoV7, showed diagnostic performance for the detection of IgG antibodies. Sensitivity was evaluated in serum samples from patients with mild to moderate or severe COVID-19 infections, which were collected at different time points, while specificity was evaluated using pre-pandemic sera. In samples from mild to moderate cases obtained ≥16 days after the onset of symptoms, the sensitivities for rCoV2, rCoV4, and rCoV7 were 66.7%, 75%, and 77.8%, respectively. For samples from severe cases, the sensitivity was above 80% for all constructs. All proteins showed high specificity (94-98%). Overall, rCoV7 (C-terminus N-protein portion) showed better diagnostic performance, with 62.3% sensitivity in moderate and severe cases and 96.6% specificity. The SARS-CoV-2 ELISA using N-protein-based constructs could be a promisor tool for investigate the epidemiology of COVID-19 and monitor population-level serosurveillance. COVID19 COVID 19 COVID-1 pandemic tests SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- studies policies study inhouse house N (N rCoV2 rCoV rCoV4 antibodies points prepandemic pre sera 16 ≥1 symptoms 667 66 7 66.7% 75 75% 778 77 8 77.8% respectively 80 9498%. 9498 94 98% . 98 (94-98%) Overall Cterminus C terminus Nprotein protein portion 623 62 3 62.3 966 96 6 96.6 Nproteinbased populationlevel population level serosurveillance COVID1 1 COVID- SARS-CoV ≥ 66.7 77.8 9498% 949 9 (94-98% 62. 96. 66. 77. (94-98 (94-9 (94- (94 (9 (

https://doi.org/10.1590/1678-4324-2024230196

12.

Elevated NS1 serum levels reduce CD119 expression and CXCL-10 synthesis in patients with dengue hemorrhagic fever NS CD CD11 CXCL10 CXCL 10 CXCL-1 CD1 CXCL1 1 CXCL-
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Garcia, Fernanda Gonçalves

; Helmo, Fernanda Rodrigues

; Silva, Marcos Vinícius da

; Rodrigues Jr., Virmondes

; Oliveira, Carlo José Freire

; Teixeira, Luciana de Almeida Silva

; Rogério, Alexandre de Paula

; Teixeira, David Nascimento Silva

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e00410-2024

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: The intensity of dengue virus (DV) replication and circulating non-structural protein 1 (NS1) levels may promote changes in the human immune response and favor severe forms of infection. We investigated the correlations between NS1 with CXCL-8, CXCL-10, IFN-γ, and IL-12p40 serum levels, and IFN-γ receptor α chain (CD119) expression, and CXCL10 production by peripheral blood mononuclear cells (PBMCs) stimulated with recombinant IFN-γ in DV-infected patients with different clinical forms. Methods: Dengue virus NS1, CXCL-8, CXCL-10, IFN-γ, and IL-12p40 serum levels were measured in 152 DV-infected patients with different clinical forms and 20 non-infected individuals (NI) using enzyme-linked immunosorbent assay (ELISA). In addition, we investigated the CXCL-10 production after in vitro IFN-γ stimulation of PBMCs from 48 DV-infected individuals (with different clinical forms of dengue fever) and 20 NI individuals using ELISA, and CD119 expression on CD14+ cells with flow cytometry. Results: Patients with dengue hemorrhagic fever (DHF) had significantly higher NS1, CXCL-8, and CXCL-10 serum levels than those with classic dengue fever (DF). The response of PBMCs to IFN-γ stimulation was lower in patients with DHF than in those with DF or dengue with complications (DWC), with lower CD119 expression and reduced CXCL-10 synthesis. In addition, these alterations are associated with high NS1 serum levels. Conclusions: Patients with DHF reported high NS1 levels, low CD119 expression, and low CXCL-10 synthesis in PBMCs, which may be associated with infection progression and severity. Background DV (DV nonstructural non structural NS (NS1 CXCL8, CXCL8 CXCL 8, 8 CXCL-8 CXCL10, 10, 10 IFNγ, IFNγ IFN γ, γ IL12p40 ILp IL 12p40 p IL-12p4 CD (CD119 CXCL1 (PBMCs DVinfected infected Methods 15 2 noninfected (NI enzymelinked enzyme linked ELISA. ELISA . (ELISA) addition CXCL-1 4 CD11 CD14 cytometry Results (DHF DF. (DF) DWC, DWC , (DWC) Conclusions severity (NS CXCL- IL12p4 12p4 IL-12p (CD11 (ELISA CD1 (DF (DWC IL12p 12p (CD1 (CD

https://doi.org/10.1590/0037-8682-0577-2023

13.

Nursing diagnoses for people hospitalized with heart failure: an integrative review failure
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Oliveira, Ana Paula Dias de

; Lima, Lucas Garcia

; Santos, Vinicius Batista

; Souza, Larissa Maiara da Silva Alves

; Lopes, Juliana de Lima

; Barros, Alba Lucia Bottura Leite de

Revista Brasileira de Enfermagem

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2024, Volume 77 Nº 3 elocation e20230471

Resumo: Es Pt En | Texto: Es Pt En | PDF: Es | PDF: Pt | PDF: En

RESUMEN Objetivos: identificar en la literatura los principales diagnósticos de enfermería según la clasificación diagnóstica NANDA-I para personas hospitalizadas con insuficiencia cardíaca. Métodos: revisión integrativa de la literatura, realizada en febrero de 2019 y actualizada en julio de 2023, en las bases de datos MEDLINE vía PubMed, LILACS, SciELO y CINAHL. Dado el uso del acrónimo PEO, se incluyeron estudios sin corte de tiempo en portugués, inglés y español. Se realizó un análisis descriptivo para presentar la información identificada. Resultados: el análisis de 27 artículos identificó 24 diagnósticos de enfermería, con énfasis en Disminución del Gasto Cardíaco, Volumen Excesivo de Líquidos, Disminución de la Tolerancia a la Actividad y Fatiga. Consideraciones Finales: la evidencia puede contribuir a mejores decisiones diagnósticas centradas en personas con insuficiencia cardíaca en busca de resultados de salud más asertivos y tiene el potencial de sustentar futuros estudios sobre un posible patrón sindrómico en esta población. Objetivos NANDAI NANDA I Métodos 201 2023 PubMed LILACS CINAHL PEO portugués español identificada Resultados 2 Cardíaco Líquidos Fatiga Finales población 20 202

RESUMO Objetivos: identificar na literatura os principais diagnósticos de enfermagem de acordo com a classificação de diagnósticos da NANDA-I para pessoas hospitalizadas com insuficiência cardíaca. Métodos: revisão integrativa da literatura, realizada em fevereiro de 2019 e atualizada em julho de 2023, nas bases de dados MEDLINE via PubMed, LILACS, SciELO e CINAHL. Diante do uso do acrônimo PEO, incluíram-se estudos sem corte temporal de tempo em português, inglês e espanhol. Realizou-se análise descritiva para apresentar as informações identificadas. Resultados: análise de 27 artigos identificou 24 diagnósticos de enfermagem, com destaque para Débito Cardíaco Diminuído, Volume de Líquidos Excessivo, Tolerância à Atividade Diminuída e Fadiga. Considerações Finais: as evidências podem contribuir para a melhor decisão diagnóstica centrada na pessoa com insuficiência cardíaca em busca de resultados em saúde mais assertivos e têm potencial para subsidiar estudos futuros sobre um possível padrão sindrômico nessa população. Objetivos NANDAI NANDA I Métodos 201 2023 PubMed LILACS CINAHL PEO incluíramse incluíram se português espanhol Realizouse Realizou identificadas Resultados 2 Diminuído Excessivo Fadiga Finais população 20 202

ABSTRACT Objectives: to identify in the literature the main nursing diagnoses according to the NANDA-I diagnostic classification for people hospitalized with heart failure. Methods: an integrative literature review, carried out in February 2019 and updated in July 2023, in the MEDLINE via PubMed, LILACS, SciELO and CINAHL databases. Given the use of acronym PEO, studies without a time cut in Portuguese, English and Spanish were included. Descriptive analysis was carried out to present the identified information. Results: analysis of 27 articles identified 24 nursing diagnoses, with emphasis on Decreased Cardiac Output, Excessive Fluid Volume, Decreased Activity Tolerance and Fatigue. Final Considerations: evidence can contribute to better diagnostic decisions centered on people with heart failure in search of more assertive health results and have the potential to support future studies on a possible syndromic pattern in this population. Objectives NANDAI NANDA I Methods review 201 2023 PubMed LILACS databases PEO Portuguese included information Results 2 Output Volume Fatigue Considerations population 20 202

https://doi.org/10.1590/0034-7167-2023-0471

14.

The sural-sparing pattern in clinical variants and electrophysiological subtypes of Guillain-Barré syndrome suralsparing sural sparing GuillainBarré Guillain Barré
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Castro, Vinicius Furtado da Silva

; Oliveira, Roberto Teodoro Gurgel de

; Santos, João Daniel Lima dos

; Mendes, Ramon de Souza

; Pessoa Neto, Agábio Diógenes

; Fidelix, Emanuela Coriolano

; Dourado Júnior, Mário Emílio Teixeira

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 Nº 4 elocation s00441785692

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis worldwide and can be classified into electrophysiological subtypes and clinical variants. Objective This study aimed to compare the frequency of the sural-sparing pattern (SSP) in subtypes and variants of GBS. Methods This retrospective cohort study analyzed clinical and electrophysiological data of 171 patients with GBS hospitalized in public and private hospitals of Natal, Rio Grande do Norte, Brazil, between 1994 and 2018; all cases were followed up by the same neurologist in a reference neurology center. Patients were classified according to electrophysiological subtypes and clinical variants, and the SSP frequency was compared in both categories. The exact Fisher test and Bonferroni correction were used for statistical analysis. Results The SSP was present in 53% (57 of 107) of the patients with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), 8% (4 of 48) of the patients with axonal subtypes, and 31% (5 of 16) of the equivocal cases. The SSP frequency in the AIDP was significantly higher than in the axonal subtypes (p < 0.0001); the value was kept high after serial electrophysiological examinations. Only the paraparetic subtype did not present SSP. Conclusion The SSP may be present in AIDP and axonal subtypes, including acute motor axonal neuropathy, but it is significantly more present in AIDP. Moreover, the clinical variants reflect a specific pathological process and are correlated to its typical electrophysiological subtype, affecting the SSP frequency. GuillainBarré Guillain Barré (GBS suralsparing sural sparing (SSP 17 Natal Norte Brazil 199 2018 center categories analysis 53 57 107 AIDP, , (AIDP) 8 4 ( 48 31 5 16 p 0.0001 00001 0 0001 0.0001) examinations neuropathy Moreover 1 19 201 10 (AIDP 3 0.000 0000 000 20 0.00 00 2 0.0 0.

Resumo Antecedentes A síndrome de Guillain-Barré (GBS) é a causa mais comum de paralisia flácida aguda em todo o mundo e pode ser classificada em subtipos eletrofisiológicos e variantes clínicas. Objetivo Este estudo teve como objetivo comparar a frequência do padrão de preservação do sural (SSP) em subtipos e variantes de GBS. Métodos É um estudo de coorte retrospectivo que analisou dados clínicos e eletrofisiológicos de 171 pacientes com GBS internados em hospitais públicos e privados de Natal, Rio Grande do Norte, Brasil, entre 1994 e 2018. Todos os casos foram acompanhados pelo mesmo neurologista em centro de referência em neurologia. Os pacientes foram classificados de acordo com os subtipos eletrofisiológicos e variantes clínicas e a frequência do SSP foi comparada em ambas as categorias. O teste exato de Fisher e a correção de Bonferroni foram utilizados para análise estatística. Resultados O SSP esteve presente em 53% (57 de 107) dos pacientes com polirradiculoneuropatia desmielinizante inflamatória aguda (PDIA), em 8% (4 de 48) dos pacientes com subtipos axonais e em 31% (5 de 16) dos casos não definidos. A frequência do SSP no AIDP foi significativamente maior do que nos subtipos axonais (p < 0,0001); o valor manteve-se elevado após exames eletrofisiológicos seriados. Apenas o subtipo paraparético não apresentou SSP. Conclusão O SSP pode estar presente na PDIA e nos subtipos axonais, incluindo a neuropatia axonal motora aguda, mas está significativamente mais presente na PDIA. Além disso, as variantes clínicas refletem um processo patológico específico e estão correlacionadas ao seu subtipo eletrofisiológico típico, afetando a frequência do SSP. GuillainBarré Guillain Barré (GBS (SSP 17 Natal Norte Brasil 199 2018 neurologia categorias estatística 53 57 107 PDIA, , (PDIA) 8 4 ( 48 31 5 16 definidos p 0,0001 00001 0 0001 0,0001) mantevese manteve se seriados disso típico 1 19 201 10 (PDIA 3 0,000 0000 000 20 0,00 00 2 0,0 0,

https://doi.org/10.1055/s-0044-1785692

15.

Anti-inflammatory and anti-oxidant action of tadalafil in testicular regeneration process after heat stress Antiinflammatory Anti inflammatory antioxidant anti oxidant
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Silva, Fernando Leonel da

; Dias, Fernanda Carolina Ribeiro

; Torres, Sandra Maria

; Lorena, Virginia Maria Barros de

; Silva, Sebastião Rogerio de Freitas

; Oliveira, Vinicius Vasconcelos Gomes de

; Oliveira Filho, Emanoel Felipe de

; Soares, Pierre Castro

; Silva Junior, Valdemiro Amaro da

Animal Reproduction

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2024, Volume 21 Nº 2 elocation e20230095

Resumo: En | Texto: En | PDF: En

Abstract Tadalafil, a potent phosphodiesterase inhibitor 5 (PDE-5), is commonly used for the management of erectile dysfunction. However, its therapeutic potential extends beyond this indication. This study aimed to investigate the impact of tadalafil on the recovery of testicular parenchyma in male Wistar rats exposed to testicular thermal stress. Fifty-four Wistar rats were subjected to testicular thermal stress and randomly assigned to receive either tadalafil treatment (TAD) or no treatment (control). TAD was administered intraperitoneally at a dose of either 0.9 mg/kg or 1.8 mg/kg. Biometric parameters, histopathological assessment of the testis, serum testosterone levels, oxidative stress, and interleukin levels were evaluated on days 7, 15, and 30 after thermal shock. The animals were euthanized at the end of each experimental period, and samples were collected. TAD treatment maintained testicular weight and reduced the testicular degenerative process up to day 7 post-injury. However, despite TAD therapy, serum testosterone levels were decreased in the treated groups at days 7 and 15 post-thermal stress. TAD also decreased TNF-α and NO levels at different doses but had no effect on IL-6. The treatment with TAD after heat shock demonstrated anti-inflammatory and antioxidant properties but did not prevent the aggravation of testicular lesions in subsequent periods, even with the systematic reduction in TNF-α and NO levels. Therefore, this selective PDE-5 inhibitor, at the dosages used, did not have a positive impact on testosterone levels during the post-thermal stress period, which could compromise the resumption of the spermatogenic process. Tadalafil PDE5, PDE5 PDE , (PDE-5) dysfunction However indication Fiftyfour Fifty four (TAD control. control . (control) 09 0 9 0. mgkg mg kg 18 1 8 1. parameters testis 3 period collected postinjury. postinjury post injury. injury post-injury therapy postthermal TNFα TNF α IL6. IL6 IL 6. 6 IL-6 antiinflammatory anti inflammatory periods Therefore PDE- (PDE-5 (control IL- (PDE- (PDE

https://doi.org/10.1590/1984-3143-ar2023-0095

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