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RESUMO: A fertirrigação é amplamente utilizada na produção de mudas de várias culturas, inclusive o maracujazeiro. Não existe consenso sobre qual solução nutritiva deve ser adotada na produção de mudas de maracujazeiro, mas por causa disso, viveiristas têm usado a fertirrigação empiricamente. O objetivo deste trabalho foi avaliar condutividades elétricas de solução nutritiva com macros e micronutrientes na produção de mudas de maracujazeiro e compará-las com uma fertirrigação adotada comercialmente. Foi utilizado delineamento experimental inteiramente casualizado, com cinco tratamentos e seis repetições. Foram estudadas quatro condutividades elétricas (0,5; 1,0; 2,0 e 4,0 dS m-1) de solução nutritiva completa e um tratamento adicional (solução nutritiva adotada comercialmente). Em substrato à base de fibra de coco, fertirrigações diárias com solução nutritiva completa (macro e micronutrientes), com condutividades elétricas entre 2,6 a 3,3 dS m-1, seguidas de duas irrigações diárias são eficientes na produção de mudas de maracujazeiro FB 300 “Araguari”, inclusive com vantagens, como maior biomassa e índice de qualidade de Dickson em relação à solução nutritiva comercial. RESUMO culturas disso empiricamente comparálas compará las comercialmente casualizado repetições 0,5 05 0 5 (0,5 1,0 10 1 20 2 2, 40 4 4, m1 m m-1 . comercialmente) coco macro micronutrientes, , micronutrientes) 26 6 33 3 3, m1, 1, 30 Araguari, Araguari “Araguari” vantagens comercial 0, (0, m- “Araguari (0 (

ABSTRACT: Fertigation is widely used in seedling production for different crops, including passion fruit. There is no consensus on the ideal nutrient solution, and as such, nurseries have used fertigation empirically. This study assessed the electrical conductivity of nutrient solution containing macro and micronutrients in passion fruit seedling production and compared it with commercially used fertigation. A completely randomized design was used, with five treatments and six repetitions. Four electrical conductivities (0.5, 1.0, 2.0 and 4.0 dS m-1) of a complete nutrient solution and an additional treatment (commercial nutrient solution) were analyzed. Daily fertigation with a complete nutrient solution (macro and micronutrients) at electrical conductivities between 2.6 and 3.3 dS m-1 followed by two daily irrigations are efficient at producing FB 300 “Araguari” passion fruit seedlings in coconut fiber substrate, with benefits such as greater biomass and better Dickson quality index when compared to commercial nutrient solution. ABSTRACT crops empirically repetitions 0.5, 05 0 5 (0.5 10 1 1.0 20 2 2. 40 4 4. m1 m analyzed 26 6 33 3 3. m- 30 Araguari “Araguari substrate 0.5 (0. 1. 0. (0 (

https://doi.org/10.1590/0103-8478cr20210442

Profile of cardiovascular diseases and physiotherapeutic intervention in a hospital emergency service
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Silva, Pedro Victor Tonicante da

; Silva, Gisele Correia da

; Alves, Letícia Soares

; Oliveira, Tatiany Ribeiro de

; Pacagnelli, Francis Lopes

Fisioterapia em Movimento

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2024, Volume 37 elocation e37106

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução As doenças cardiovasculares (DCV) repre-sentam a principal causa de morte global, destacando-se em internações e gastos. Diante disso, é essencial compreender as principais DCV em pacientes admitidos em serviços de emergência hospitalar e a atuação do fisioterapeuta para planejamento e direcionamento dos serviços de saúde e para denotar a participação e incentivar formações fisioterapêuticas específicas no contexto da atenção terciária. Objetivo Traçar o perfil de emergências cardiovasculares e avaliar a atuação fisioterapêutica em pacientes adultos de serviço de emergência de um hospital no interior do estado de São Paulo. Métodos Trata-se de um estudo observacional, em que foram analisadas 1.256 fichas de passagem de plantão, no período de oito meses. Os dados coletados foram idade, sexo, hipótese diagnóstica cardiovascular e tratamento fisioterapêutico realizado. Resultados Foram incluídos 75 pacientes que apresentavam o perfil de emergências cardiovasculares, sendo as mais prevalentes: insuficiência cardíaca (n = 21), síndrome corona-riana aguda (n = 14), infarto agudo do miocárdio (n = 13), bradarritmia (n = 6) e crise hipertensiva (n = 5). Em relação à atuação fisioterapêutica e suas aplicações, as mais frequentes foram manejo da ventilação mecânica invasiva (n = 34), manobras de reexpansão pulmonar (n = 17), auxílio a intubação orotraqueal (n = 17), ventila-ção mecânica não invasiva (n = 14), manobras de higiene brônquica (n = 12), cinesioterapia (n = 10) e sedestação (n = 10). Conclusão A insuficiência cardíaca e a síndrome coronária aguda foram as doenças cardiovasculares que mais ocasionaram internação no serviço de emergência hospitalar e as condutas com ênfase no aparelho respiratório foram as mais aplicadas. (DCV representam repre sentam global destacandose destacando se gastos disso terciária Paulo Tratase Trata observacional 1256 1 256 1.25 plantão meses idade sexo realizado 7 prevalentes n 21, 21 , 21) coronariana corona riana 14, 14 14) 13, 13 13) 6 5. 5 . 5) aplicações 34, 34 34) 17, 17 17) ventila ção 12, 12 12) 10 10. aplicadas 125 25 1.2 2 3 1.

Abstract Introduction Cardiovascular disease (CVD) is the lead-ing cause of death globally, with a high proportion of hospitalizations and costs. In view of this, it is essential to understand the main CVDs in patients admitted to hospital emergency services and the role of physiotherapists, in order to plan and direct health services, and to denote participation and encourage specific physiotherapy training in the context of tertiary care. Objective To outline the profile of cardiovascular emergencies and to evaluate physiotherapy in adult patients in the emergency department of a hospital in the interior of the state of São Paulo. Methods This was an observational study which analyzed 1,256 on-call records over a period of eight months. The data collected included age, gender, cardiovascular diagnostic hypothesis and physiotherapy treatment carried out. Results A total of 75 patients with cardiovascular emergencies were included, the most prevalent of which were: heart failure (n = 21), acute coronary syndrome (n = 14), acute myocardial infarction (n = 13), bradyarrhythmia (n = 6) and hypertensive crisis (n = 5). Regarding physiotherapeutic actions and their applications, the most frequent were invasive mechanical ventilation management (n = 34), lung re-expansion maneuvers (n = 17), orotracheal intubation assistance (n = 17), non-invasive mechanical ventilation (n = 14), bronchial hygiene maneuvers (n = 12), kinesiotherapy (n = 10) and sedation (n = 10). Conclusion Heart failure and acute coronary syndrome were the cardiovascular diseases that caused the most admissions to the hospital emergency department and that the procedures with an emphasis on the respiratory system were the most applied. CVD (CVD leading lead ing globally costs this physiotherapists care Paulo 1256 1 256 1,25 oncall call months age gender out 7 n 21, 21 , 21) 14, 14 14) 13, 13 13) 6 5. 5 . 5) applications 34, 34 34) reexpansion re expansion 17, 17 17) noninvasive non 12, 12 12) 10 10. applied 125 25 1,2 2 3 1,

https://doi.org/10.1590/fm.2024.37106

Color measurements in annatto (Bixa orellana L.) seeds Bixa L. L
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Carvalho, Paulo Roberto Nogueira

; Silva, Mariana Aparecida Almeida da

; Oliveira, João Victor Silva de

; Fabri, Eliane Gomes

; Silva, Marta Gomes da

Brazilian Journal of Food Technology

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2024, Volume 27 elocation e2023063

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O Brasil tem se firmado como o maior produtor mundial de sementes de urucum (Bixa orellana L.). Felizmente, o aumento da produção nacional tem sido acompanhado por uma melhoria da qualidade dessa matéria-prima. O urucum é uma cultura típica de pequenos produtores, que em geral usa seu conhecimento empírico para avaliar a qualidade do material que está produzindo. A observação visual da cor das sementes de urucum tem sido considerada padrão de qualidade por muitos produtores. Para avaliar as evidências científicas, o presente estudo avaliou amostras de sementes de urucum de 51 acessos do banco de germoplasma do Instituto Agronômico de Campinas (IAC), para determinar se existe correlação entre as concentrações de pigmentos com a cor das sementes e a influência da umidade nessa correlação. Foram avaliadas também as correlações entre as concentrações de pigmentos, umidade, lipídios e a cor (L*, a*, b*). Para a avaliação da cor, utilizamos um colorímetro com a medida da cor pelo sistema CIE L*, a*, b*. Apenas a correlação simples entre as variáveis Umidade e Lipídios foi considerada forte, pela classificação usada neste estudo. Quando se remove o efeito da Umidade (correlação parcial), apenas as variáveis bixina e a* apresentaram correlação significativa, considerada fraca pela classificação utilizada. Portanto, mesmo considerada fraca, há uma correspondência entre a cor vermelha das sementes de urucum com a concentração de bixina das amostras estudadas. Contudo, a diferença da cor (ΔEab) entre as amostras com maior e menor teor de bixina foi de apenas 1,44. Essa diferença indica que grandes variações nas concentrações de bixina nas sementes de urucum podem levar a pequenas variações de cor, dificultando o uso desse critério para o controle de qualidade desses grãos. Bixa L.. L L. . L.) Felizmente matériaprima. matériaprima matéria prima. prima matéria-prima produtores produzindo científicas 5 IAC, IAC , (IAC) (L* b b* b*) L* forte parcial, parcial parcial) significativa utilizada Portanto estudadas Contudo ΔEab (ΔEab 144 1 44 1,44 grãos (IAC (L 14 4 1,4 1,

Abstract Brazil has emerged as the world's largest producer of annatto seeds (Bixa orellana L.). Fortunately, the increase in national production has been accompanied by an improvement in the quality of this raw material. Annatto is a typical crop of small producers who usually use their empirical knowledge to evaluate the quality of the crop. Thefore, the visual observation of the color of annatto seeds has been considered a quality standard by many producers. To evaluate the scientific evidence, the present study evaluated annatto seeds from 51 accessions of the germplasm bank of the Agronomic Institute (Instituto Agronômico de Campinas - IAC) to determine a possible correlation between the pigment’s contents and the color of annatto seeds as well as the influence of humidity on this correlation. The correlations between the concentrations of pigments, humidity, lipids, and color (L*, a*, b*) were also evaluated. The color was evaluated using a colorimeter with measurements of the CIE L*, a*, b* scale. Only the correlation between the variables moisture and lipids was considered strong through the simple correlation, while the variables bixin content and coordinate a* presented a significant correlation while eliminating the effect of moisture (partial correlation). Thus, a correlation between the red color and the bixin concentration of annatto seeds was observed even though it was a weak correlation. In turn, the color difference (ΔEab) between the samples with higher and lower bixin contents was only 1.44. This difference indicates that large variations in the bixin concentrations may lead to small color changes in the annatto seeds, impairing the use of this criterion for quality control of these seeds. worlds world s Bixa L.. L L. . L.) Fortunately material Thefore evidence 5 Instituto IAC pigments pigment (L* b L* scale partial correlation) Thus turn ΔEab (ΔEab 144 1 44 1.44 (L 14 4 1.4 1.

https://doi.org/10.1590/1981-6723.06323

Checklist of the species of the Order Characiformes (Teleostei: Ostariophysi) Teleostei (Teleostei Ostariophysi
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Toledo-Piza, Mônica

; Baena, Eduardo G.

; Dagosta, Fernando C. P.

; Menezes, Naércio A.

; Ândrade, Marcelo

; Benine, Ricardo C.

; Bertaco, Vinicius A.

; Birindelli, José Luís O.

; Boden, Gert

; Buckup, Paulo A.

; Camelier, Priscila

; Carvalho, Fernando R. de

; Castro, Ricardo M. C.

; Chuctaya, Junior

; Decru, Eva

; Derijst, Eddy

; Dillman, Casey B.

; Ferreira, Katiane M.

; Merxem, Dimitri G.

; Giovannetti, Victor

; Hirschmann, Alice

; Jégu, Michel

; Jerep, Fernando C.

; Langeani, Francisco

; Lima, Flávio C. T.

; Lucena, Carlos A. S.

; Lucena, Zilda Margarete S.

; Malabarba, Luiz R.

; Malabarba, Maria Cláudia S. L.

; Marinho, Manoela M. F.

; Mathubara, Kleber

; Mattox, George M. T.

; Melo, Bruno F.

; Moelants, Tuur

; Moreira, Cristiano R.

; Musschoot, Tobias

; Netto-Ferreira, André L.

; Ota, Rafaela P.

; Oyakawa, Osvaldo T.

; Pavanelli, Carla S.

; Reis, Roberto E.

; Santos, Osmar

; Serra, Jane Piton

; Silva, Gabriel S. C.

; Silva-Oliveira, Cárlison

; Souza-Lima, Rosana

; Vari, Richard P.

; Zanata, Angela M.

Neotropical Ichthyology

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2024, Volume 22 Nº 1 elocation e230086

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Uma lista de peixes recentes e fósseis da Ordem Characiformes é apresentada e acredita-se que a lista esteja completa até 2022. Ao todo, 47 colaboradores verificaram e forneceram informações sobre táxons de sua especialidade. A lista está organizada em ordem alfabética por família e em seguida gênero e inclui todos os sinônimos disponíveis. De um total de 3.087 nomes de grupos de espécies e 527 nomes de grupos de gêneros, 2.334 espécies são atualmente tratadas como válidas e atribuídas a 301 gêneros e 24 famílias. Este total inclui 25 espécies fósseis, das quais 21 são incluídas em oito famílias recentes e quatro são Incertae sedis em Characiformes, mas não inclui cinco espécies baseadas em fósseis que foram incorretamente consideradas como Characiformes. O status de 79 espécies nominais permanece não resolvido. Quando há duas hipóteses concorrentes sobre a validade de um nome, uma delas é escolhida e a interpretação alternativa é fornecida na seção de comentários do nome em questão. Dados sobre distribuição geográfica são apresentados através de números que correspondem a regiões para as quais há registro de ocorrência da espécie. Uma lista de nomes indisponíveis foi listada no final do texto, pois alguns desses nomes precisam ser mais bem investigados para certificar seu status. acreditase acredita se 2022 todo 4 especialidade disponíveis 3087 3 087 3.08 52 2334 2 334 2.33 30 7 resolvido questão espécie texto 202 308 08 3.0 5 233 33 2.3 20 0 3. 23 2.

Abstract A checklist of recent and fossil fishes of the Order Characiformes is presented herein and believed to be complete through 2022. A total of 47 collaborators checked and provided information about their taxa of expertise. The list is arranged in alphabetical order by family and then genus and includes all available synonyms. From a total of 3,087 species group names and 527 genus group names, 2,334 species are currently treated as valid, and assigned to 301 genera and 24 families. This total includes 25 species known only from the fossil record, of which 21 are assigned to eight extant families and four are Incertae sedis in Characiformes, but does not include five species based on fossil which were wrongly treated in Characiformes. The status of 79 nominal species remains unresolved. When there are two competing hypotheses about the validity of a name, one of them is chosen and the alternate interpretation is provided in the remark section of that name. Distributional summaries are presented as numbers that correspond to areas for which there is a record of occurrence of the species. A list of unavailable names is provided at the end since some of those names may need additional research to certify their status. 2022 4 expertise synonyms 3087 3 087 3,08 52 2334 2 334 2,33 valid 30 7 unresolved name 202 308 08 3,0 5 233 33 2,3 20 0 3, 23 2,

https://doi.org/10.1590/1982-0224-2023-0086

Modeling spatial trends and selecting tropical wheat genotypes in multi-environment trials multienvironment multi environment
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Silva, Caique Machado e

; Signorini, Victor Silva

; Chaves, Saulo Fabrício da Silva

; Souza, Diana Jhulia Palheta de

; Lima, Gabriel Wolter

; Casagrande, Cleiton Renato

; Mezzomo, Henrique Caletti

; Ribeiro, João Paulo Oliveira

; Nardino, Maicon

Crop Breeding and Applied Biotechnology

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2024, Volume 24 Nº 2 elocation e47582421

Resumo: En | Texto: En | PDF: En

Abstract In many cases, traditional analysis of breeding trials based on analysis of variance (ANOVA) do not allow a suitable genetic evaluation. Alternatively, mixed model-based approaches create the possibility of dealing with unbalanced data and modeling spatial trends. The aims of this study were to compare the goodness-of-fit of the model and the genotype ranking through different residual modeling approaches and to select the best performing tropical wheat genotypes based on the best-fitting model. A panel of tropical wheat genotypes was evaluated in three field trials conducted between 2020 and 2021 for grain yield. Linear mixed model analyses were used on the data to estimate the genetic parameters and to predict the genotypic values in analyses of single- and multi-environment trials. Accounting for spatial trends in the analyses of single- and multi-environment trials provides better outcomes than the compound symmetry model does. cases ANOVA (ANOVA evaluation Alternatively modelbased goodnessoffit goodness fit bestfitting fitting 202 yield single multienvironment multi environment does 20 2

https://doi.org/10.1590/1984-70332024v24n1a10

Asthma in the Brazilian Unified Health Care System: an epidemiological analysis from 2008 to 2021 System 200 202 20 2
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Pinheiro, David Halen Araújo

; Souza, João Victor Hermógenes de

; Justo, Alberto Fernando Oliveira

; Carvalho-Pinto, Regina Maria

; Lima, Fabiano Francisco de

; Carvalho, Celso R F

Jornal Brasileiro de Pneumologia

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2024, Volume 50 Nº 2 elocation e20230364

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To analyze the number of hospitalizations, the length of hospital stay, and mortality due to asthma, as well as the costs to the Unified Health Care System in Brazil between 2008 and 2021. Methods: This was a cross-sectional epidemiological study using data from the Information Technology Department of the Brazilian Unified Health Care System. Proportional hospitalization and death rates were estimated per 100,000 population by age, microregion, and year. Results: The number of hospitalizations and deaths due to asthma decreased from 2008 to 2021 (205,392 vs. 55,009 and 822 vs. 327, respectively). In addition, a between-sex difference was observed in asthma-related hospitalizations in 2008, and more men were hospitalized in 2021 (51.8%). Asthma mortality rates were similar for both sexes (50.0% each) in 2008, and a slight increase was observed in women’s deaths in 2021 (52.9%). Even so, approximately one death/day and more than 55,000 hospitalizations were observed yearly, with a mean length of hospital stay of three days. Additionally, the Southeast region allocated more financial resources to asthma-related hospitalizations. Conclusions: Our results showed that the number of deaths and hospitalizations due to asthma substantially declined during the study period. Objective 200 Methods crosssectional cross sectional 100000 100 000 100,00 age microregion year Results 202 205,392 205392 205 392 (205,39 vs 55009 55 009 55,00 82 327 respectively. respectively . respectively) addition betweensex sex asthmarelated related 51.8%. 518 51.8% 51 8 (51.8%) 50.0% 500 50 0 (50.0 each womens women s 52.9%. 529 52.9% 52 9 (52.9%) so deathday day 55000 yearly days Additionally Conclusions period 20 10000 10 00 100,0 205,39 20539 39 (205,3 5500 5 55,0 32 51.8 (51.8% 50.0 (50. 52.9 (52.9% 2 1000 1 100, 205,3 2053 3 (205, 550 55, 51. (51.8 50. (50 52. (52.9 205, (205 (51. (5 (52. (20 (51 ( (52 (2

https://doi.org/10.36416/1806-3756/e20230364

Analytical and computational investigation of the flexural behavior of UHPFRC beams
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Santos Junior, Paulo Sergio Mota dos

; Cardoso, Felipe Matias do Nascimento

; Sacramento, Paulo Victor Prazeres

; Branco, Vitor Hugo Lopes

; Picanço, Marcelo de Souza

; Oliveira, Denio Ramam Carvalho de

Latin American Journal of Solids and Structures

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2024, Volume 21 Nº 1 elocation e518

Resumo: En | Texto: En | PDF: En

Abstract Analytical and computational calibrations and subsequent parametric analyses were performed on the four UHPFRC beams under flexure to estimate their actual shear strength. The computational models were calibrated using different values for the CDP parameters, and a finite element mesh sensitivity study was conducted. These models predicted the experimental behavior satisfactorily, and the analytical model was also able to find the beams’ failure loads and proved to be a simple tool to estimate their behavior. The parametric analysis showed that the current beams did not require stirrups once the UHPFRC had high shear strength, and the maximum shear capacity was accurately determined. strength parameters conducted satisfactorily determined

https://doi.org/10.1590/1679-78257804

Segmental areas of denervation in post-polio syndrome postpolio post polio
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Braga, Vinícius Lopes

; Moreira, Heloísa Lopes Cohim

; Fraiman, Pedro Henrique Almeida

; Sarmento, Filipe Pereira

; Farias, Igor Braga

; Serrano, Paulo de Lima

; Badia, Bruno de Mattos Lombardi

; Chieia, Marco Antônio Troccoli

; Pinto, Wladimir Bocca Vieira de Rezende

; Souza, Paulo Victor Sgobbi de

; Oliveira, Acary Souza Bulle

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 Nº 2 elocation s00441779507

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1055/s-0044-1779507

Accuracy of the Verbal Autopsy questionnaire in the diagnosis of COVID-19 deaths in a Brazilian capital COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Campos, Marcos Adriano Garcia

; Cutrim, Ézio Arthur Monteiro

; Cutrim, Érico Murilo Monteiro

; Oliveira, João Victor Pimentel de

; Oliveira, Eduardo José Silva Gomes de

; Pontes, Daniel de Brito

; Figueiredo Neto, José Albuquerque de

; Silva, Gyl Eanes Barros

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e33

Resumo: En | Texto: En | PDF: En

ABSTRACT The Verbal Autopsy (VA) is a questionnaire about the circumstances surrounding a death. It was widely used in Brazil to assist in postmortem diagnoses and investigate excess mortality during the Coronavirus Disease 2019 (COVID-19) pandemic. This study aimed to determine the accuracy of investigating acute respiratory distress syndrome (ARDS) using VA. This is a cross-sectional study with prospective data collected from January 2020 to August 2021 at the Death Verification Service of Sao Luis city, Brazil. VA was performed for suspected COVID-19 deaths, and one day of the week was randomly chosen to collect samples from patients without suspected COVID-19. Two swabs were collected after death and subjected to reverse transcription-polymerase chain reaction (RT-PCR) for SARS-CoV-2 detection. Of the 250 cases included, the VA questionnaire identified COVID-19-related ARDS in 67.2% (52.98% were positive for COVID-19). The sensitivity of the VA questionnaire was 0.53 (0.45–0.61), the specificity was 0.75 (0.64–0.84), the positive predictive value was 0.81 (0.72–0.88), and the negative predictive value was 0.44 (0.36–0.53). The VA had a lower-than-expected accuracy for detecting COVID-19 deaths; however, because it is an easily accessible and cost-effective tool, it can be combined with more accurate methods to improve its performance. (VA 201 COVID19 COVID 19 (COVID-19 pandemic (ARDS crosssectional cross sectional 202 city COVID-1 deaths COVID19. 19. transcriptionpolymerase transcription polymerase RTPCR RT PCR (RT-PCR SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- detection 25 included COVID19related COVIDrelated related 672 67 67.2 52.98% 5298 52 98 (52.98 . COVID-19) 053 0 53 0.5 0.45–0.61, 045061 0.45–0.61 , 45 61 (0.45–0.61) 075 75 0.7 0.64–0.84, 064084 0.64–0.84 64 84 (0.64–0.84) 081 81 0.8 0.72–0.88, 072088 0.72–0.88 72 88 (0.72–0.88) 044 44 0.4 0.36–0.53. 036053 0.36–0.53 36 (0.36–0.53) lowerthanexpected lower than expected however costeffective cost effective tool performance 20 COVID1 1 (COVID-1 COVID- SARS-CoV 6 67. 52.98 529 5 9 (52.9 05 0. 04506 0.45–0.6 4 (0.45–0.61 07 7 06408 0.64–0.8 8 (0.64–0.84 08 07208 0.72–0.8 (0.72–0.88 04 03605 0.36–0.5 3 (0.36–0.53 (COVID- 52.9 (52. 0450 0.45–0. (0.45–0.6 0640 0.64–0. (0.64–0.8 0720 0.72–0. (0.72–0.8 0360 0.36–0. (0.36–0.5 (COVID 52. (52 045 0.45–0 (0.45–0. 064 0.64–0 (0.64–0. 072 0.72–0 (0.72–0. 036 0.36–0 (0.36–0. (5 0.45– (0.45–0 06 0.64– (0.64–0 0.72– (0.72–0 03 0.36– (0.36–0 ( 0.45 (0.45– 0.64 (0.64– 0.72 (0.72– 0.36 (0.36– (0.45 0.6 (0.64 (0.72 0.3 (0.36 (0.4 (0.6 (0.7 (0.3 (0. (0

https://doi.org/10.1590/s1678-9946202466033

10.

Chemical transdifferentiation of somatic cells to neural cells: a systematic review
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Visintin, Paulo Victor

; Zampieri, Bruna Lancia

; Griesi-Oliveira, Karina

einstein (São Paulo)

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2024, Volume 22 elocation eRW0423

Resumo: En | Texto: En | PDF: En

ABSTRACT Introduction Transdifferentiation is the conversion of a specific somatic cell into another cell type, bypassing a transient pluripotent state. This implies a faster method to generate cells of interest with the additional benefit of reduced tumorigenic risk for clinical use. Objective We describe protocols that use small molecules as direct conversion inducers, without the need for exogenous factors, to evaluate the potential of cell transdifferentiation for pharmacological and clinical applications. Methods In this systematic review, using PRISMA guidelines, we conducted a personalized search strategy in four databases (PubMed, Scopus, Embase, and Web Of Science), looking for experimental works that used exclusively small molecules for transdifferentiation of non-neural cell types into neural lineage cells. Results We explored the main biological mechanisms involved in direct cell conversion induced by different small molecules used in 33 experimental in vitro and in vitro transdifferentiation protocols. We also summarize the main characteristics of these protocols, such as the chemical cocktails used, time for transdifferentiation, and conversion efficiency. Conclusion Small molecules-based protocols for neuronal transdifferentiation are reasonably safe, economical, accessible, and are a promising alternative for future use in regenerative medicine and pharmacology. type state inducers factors applications review guidelines PubMed, PubMed (PubMed Scopus Embase Science, Science , Science) nonneural non 3 efficiency moleculesbased based safe economical accessible pharmacology

https://doi.org/10.31744/einstein_journal/2024rw0423

11.

Brazilian consensus recommendations on the diagnosis and treatment of autoimmune encephalitis in the adult and pediatric populations
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Dutra, Lívia Almeida

; Silva, Pedro Victor de Castro

; Ferreira, João Henrique Fregadolli

; Marques, Alexandre Coelho

; Toso, Fabio Fieni

; Vasconcelos, Claudia Cristina Ferreira

; Brum, Doralina Guimarães

; Pereira, Samira Luisa dos Apóstolos

; Adoni, Tarso

; Rocha, Leticia Januzi de Almeida

; Sampaio, Leticia Pereira de Brito

; Sousa, Nise Alessandra de Carvalho

; Paolilo, Renata Barbosa

; Pizzol, Angélica Dal

; Costa, Bruna Klein da

; Disserol, Caio César Diniz

; Pupe, Camila

; Valle, Daniel Almeida do

; Diniz, Denise Sisterolli

; Abrantes, Fabiano Ferreira de

; Schmidt, Felipe da Rocha

; Cendes, Fernando

; Oliveira, Francisco Tomaz Meneses de

; Martins, Gabriela Joca

; Silva, Guilherme Diogo

; Lin, Katia

; Pinto, Lécio Figueira

; Santos, Mara Lúcia Schimtz Ferreira

; Gonçalves, Marcus Vinícius Magno

; Krueger, Mariana Braatz

; Haziot, Michel Elyas Jung

; Barsottini, Orlando Graziani Povoas

; Nascimento, Osvaldo José Moreira do

; Nóbrega, Paulo Ribeiro

; Proveti, Priscilla Mara

; Castilhos, Raphael Machado do

; Daccach, Vanessa

; Glehn, Felipe von

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 Nº 7 elocation s00441788586

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes Encefalites autoimunes (EAIs) são um grupo de doenças inflamatórias caracterizadas pela presença de anticorpos contra antígenos neuronais e gliais, que ocasionam sintomas psiquiátricos subagudos, queixas de memória e distúrbios anormais do movimento. A maioria dos pacientes é jovem, e o atraso no tratamento está associado a pior prognóstico. Objetivo Com o apoio da Academia Brasileira de Neurologia (ABN) e da Sociedade Brasileira de Neurologia Infantil (SBNI), desenvolvemos um consenso sobre o diagnóstico e o tratamento da EAIs no Brasil utilizando a metodologia Delphi. Métodos Um total de 25 especialistas, incluindo neurologistas e neurologistas infantis, foram convidados a participar. Resultados Os especialistas concordaram que os pacientes com critérios de possíveis EAIs devem ser submetidos ao rastreio de anticorpos antineuronais no soro e no líquido cefalorraquidiano (LCR) por meio das técnicas de ensaio baseado em tecidos (tissue-based assay, TBA, em inglês) e ensaio baseado em células (cell-based assay, CBA, em inglês). As crianças também devem ser submetidas ao rastreio de de anticorpo contra a glicoproteína da mielina de oligodendrócitos (anti-myelin oligodendrocyte glycoprotein, anti-MOG, em inglês). O tratamento deve ser iniciado dentro das primeiras 4 semanas dos sintomas, sendo as opções de primeira linha metilprednisolona combinada com imunoglobulina intravenosa (IGIV) ou plasmaférese. O tratamento de segunda linha inclui rituximabe e ciclofosfamida. Bortezomib e tocilizumab são opções de tratamento de terceira linha. A maioria das crises epilépticas nas EAIs são sintomáticas, e os fármacos anticrise podem ser desmamadas após a fase aguda. Em relação à encefalite antirreceptor de N-metil-D-aspartato (anti-N-methyl-D-aspartate receptor, anti-NMDAR, em inglês), os especialistas concordaram que agentes imunossupressores orais não devem ser usados. Os pacientes devem ser avaliados na fase aguda e pós-aguda mediante escalas funcionais e cognitivas, como Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Modified Rankin Scale (mRS), e Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusão Esta pesquisa oferece evidências tangíveis do manejo efetivo de pacientes com EAIs no sistema de saúde Brasileiro. (EAIs gliais subagudos movimento jovem prognóstico ABN (ABN SBNI, SBNI , (SBNI) Delphi 2 infantis participar LCR (LCR tissuebased tissue based assay TBA inglês cellbased cell CBA inglês. . antimyelin anti myelin glycoprotein antiMOG, antiMOG MOG, MOG anti-MOG IGIV (IGIV plasmaférese ciclofosfamida sintomáticas NmetilDaspartato N metil D aspartato antiNmethylDaspartate methyl aspartate receptor antiNMDAR, antiNMDAR NMDAR, NMDAR anti-NMDAR inglês, usados pósaguda pós cognitivas MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) Brasileiro (SBNI (MMSE (MoCA (mRS (CASE

Abstract Background Autoimmune encephalitis (AIE) is a group of inflammatory diseases characterized by the presence of antibodies against neuronal and glial antigens, leading to subacute psychiatric symptoms, memory complaints, and movement disorders. The patients are predominantly young, and delays in treatment are associated with worse prognosis. Objective With the support of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN) and the Brazilian Society of Child Neurology (Sociedade Brasileira de Neurologia Infantil, SBNI), a consensus on the diagnosis and treatment of AIE in Brazil was developed using the Delphi method. Methods A total of 25 panelists, including adult and child neurologists, participated in the study. Results The panelists agreed that patients fulfilling criteria for possible AIE should be screened for antineuronal antibodies in the serum and cerebrospinal fluid (CSF) using the tissue-based assay (TBA) and cell-based assay (CBA) techniques. Children should also be screened for anti-myelin oligodendrocyte glucoprotein antibodies (anti-MOG). Treatment should be started within the first 4 weeks of symptoms. The first-line option is methylprednisolone plus intravenous immunoglobulin (IVIG) or plasmapheresis, the second-line includes rituximab and/or cyclophosphamide, while third-line treatment options are bortezomib and tocilizumab. Most seizures in AIE are symptomatic, and antiseizure medications may be weaned after the acute stage. In anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the panelists have agreed that oral immunosuppressant agents should not be used. Patients should be evaluated at the acute and postacute stages using functional and cognitive scales, such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Modified Rankin Scale (mRS), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusion The present study provides tangible evidence for the effective management of AIE patients within the Brazilian healthcare system. (AIE antigens symptoms complaints disorders young prognosis Academia ABN Sociedade Infantil SBNI, SBNI , SBNI) method 2 neurologists CSF (CSF tissuebased tissue based TBA (TBA cellbased cell CBA (CBA techniques antimyelin anti myelin antiMOG. antiMOG MOG . (anti-MOG) firstline line IVIG (IVIG plasmapheresis secondline second andor cyclophosphamide thirdline third tocilizumab symptomatic stage antiNmethylDaspartate N methyl D aspartate antiNMDAR NMDAR (anti-NMDAR used scales MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) system (anti-MOG (MMSE (MoCA (mRS (CASE

https://doi.org/10.1055/s-0044-1788586

12.

HPV and coronary diseases in menopausal women: an integrative review women
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Granja, Andrea de Neiva

; Lima, Andressa Bianca Reis

; Martins, Paulo Victor Brito

; Salgado, Bernardete Jorge Leal

; Costa, Rui Miguel Gil da

; Brito, Haissa Oliveira

; Salgado Filho, Natalino

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-rbgo57

Resumo: En | Texto: En | PDF: En

Abstract High-risk human papillomavirus (HPV) infection is associated with cervical cancer while low-risk HPV strains mostly cause benign lesions. Multiple studies have also associated HPV with coronary artery (CAD) disease in women. Furthermore, the climacteric period in women, triggers chronic inflammation and has major implications for CAD and associated lipid disorders. The association of HPV with coronary artery disease in climacteric women has few studies, and the objective of this review is to gather and analyse scientific data on the subject. This is an integrative review performed on PubMed and Google Scholar using the keywords “HPV”, “coronary heart disease” and “climacteric”, among these keywords the boolean operator AND and the publication date filter. (2018 onwards). Five articles were found, whose main results show presence of high-risk vaginal HPV in climacteric women. Climacterium and HPV were associated with a three-fold increased risk of CAD, as well as with factors related to menopause that promote atheroma formation, lipid disorders and chronic inflammation. Thus, these results support the association between HPV infection and CAD in climacteric women, possibly via chronic inflammation, hormonal factors related to menopause and dyslipidemia. Highrisk High (HPV lowrisk low lesions (CAD Furthermore subject HPV, , “HPV” climacteric, “climacteric” filter 2018 (201 onwards. onwards . onwards) found highrisk high threefold three fold formation Thus dyslipidemia “HPV “climacteric 201 (20 20 (2 2 (

https://doi.org/10.61622/rbgo/2024rbgo57

13.

Acute renal failure, COVID-19 and deaths, worrying rates in intensive care units: a cross-sectional study failure COVID19 COVID 19 COVID-1 deaths units crosssectional cross sectional COVID1 1 COVID-
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Watanabe, Yoshimi José Ávila

; Carvalho, Lívia Maria Rezende

; Guedes, João Victor Marques

; Baldoni, André Oliveira

; Belo, Vinícius Silva

; Otoni, Alba

Sao Paulo Medical Journal

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2024, Volume 142 Nº 6 elocation e2023150

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Acute kidney failure is a serious consequence of coronavirus disease 2019 (COVID-19). OBJECTIVES: To identify the prevalence of COVID-19, kidney failure, frequency of death, and associated factors in patients receiving intensive care. DESIGN AND SETTING: Analytical cross-sectional study conducted in the intensive care unit (ICU) of a medium-sized philanthropic general hospital in center-west Minas Gerais. METHODS: Adults and older individuals who underwent real-time polymerase chain reaction testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were evaluated by the nephrology team. RESULTS: Among the 176 patients, the prevalence of COVID-19 and acute kidney injury (AKI) were 103 (58.5%) and 132 (75%), respectively, and 44 (25%) had chronic kidney disease (CKD) and 16 (15,5%) were positive for SARS-CoV-2. In the Charlson index classification, which estimates the risk of death, a statistically significant difference was identified in the percentages of groups with and without COVID-19 for indices 0, 1, and 2. There was a significant association between kidney disease and ICU mortality (P < 0.05). Patients with CKD had fewer fatal outcomes (13/97, 13.4%) than those with AKI (85/97, 87.6%). CONCLUSIONS: COVID-19 rates remained high long after diagnosis and prevention of SARS-CoV-2 infection. In addition, a higher death rate among patients who developed AKI, whose prevalence was also greater than that in the national literature, regardless of the presence of COVID-19, revealed a worrying scenario and corroborated the need for early and judicious approaches to preserve the lives of patients with AKI admitted to intensive care units. BACKGROUND 201 COVID19. COVID19 COVID 19 . (COVID-19) OBJECTIVES COVID19, 19, SETTING crosssectional cross sectional (ICU mediumsized medium sized centerwest center west Gerais METHODS realtime real time SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 team RESULTS 17 COVID-1 (AKI 10 58.5% 585 58 5 (58.5% 13 75%, 75 75% , (75%) respectively 4 25% 25 (25% (CKD 1 15,5% 155 15 (15,5% SARSCoV2. classification 0 P 0.05. 005 0.05 05 0.05) 13/97, 1397 97 (13/97 13.4% 134 85/97, 8597 85 (85/97 87.6%. 876 87.6% 87 6 87.6%) CONCLUSIONS SARS-CoV- infection addition literature units 20 COVID1 (COVID-19 (SARS-CoV- COVID- 58.5 (58.5 7 (75% (25 15,5 (15,5 00 0.0 13/97 139 9 (13/9 13.4 85/97 859 8 (85/9 87.6 SARS-CoV (COVID-1 (SARS-CoV 58. (58. (75 (2 15, (15, 0. 13/9 (13/ 13. 85/9 (85/ 87. (COVID- (58 (7 ( (15 13/ (13 85/ (85 (COVID (5 (1 (8

https://doi.org/10.1590/1516-3180.2023.0150.r1.13052024

14.

Histoplasmosis in a fingolimod-treated patient: case report and scoping review fingolimodtreated fingolimod treated patient
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Oliveira, Vítor Falcão de

; Silva, Guilherme Diogo da

; Silva, Larissa Teixeira

; Gonçalves, Victor Lucas

; Rivas, Paula Emilia

; Marques, Alexandre Coelho

; Taborda, Mariane

; Magri, Adriana Satie Gonçalves Kono

; Apóstolos-Pereira, Samira Luisa

; Callegaro, Dagoberto

; Magri, Marcello Mihailenko Chaves

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e39

Resumo: En | Texto: En | PDF: En

ABSTRACT Fingolimod is a sphingosine-1-phosphate receptor modulator used to treat multiple sclerosis. While fingolimod has been associated with an increased risk of cryptococcal meningitis, its correlation with other deep mycoses remains unclear. In this study, we conducted a scoping review of fingolimod associated with histoplasmosis, based on a case report, a literature review, and data from the FDA Adverse Events Reporting System (FAERS) as of January 24th, 2023. A 30-year-old Brazilian woman diagnosed with relapsing-remitting multiple sclerosis, receiving a daily dose of 0.5 mg of fingolimod, presented with a two-month history of fever and unintended weight loss, accompanied by lymphadenopathy, splenomegaly, and lung involvement was investigated. Biopsy of a lung nodule revealed fungal structures suggestive of Histoplasma sp. Additionally, serological testing yielded positive for Histoplasma capsulatum. Disseminated histoplasmosis should be considered in the differential diagnosis of febrile syndromes in patients undergoing fingolimod therapy for multiple sclerosis, particularly in the Americas, where this mycosis is endemic. Treatment with itraconazole and modification of immunotherapy can achieve excellent clinical outcomes. sphingosine1phosphate sphingosinephosphate sphingosine 1 phosphate sclerosis meningitis unclear study report FAERS (FAERS 24th th 2023 30yearold yearold 30 year old relapsingremitting relapsing remitting 05 0 5 0. twomonth two month loss lymphadenopathy splenomegaly investigated sp Additionally capsulatum Americas endemic outcomes 202 3 20 2

https://doi.org/10.1590/s1678-9946202466039

15.

Risk of smoking cessation treatment dropout: a cohort to help (re)think care dropout rethink re think
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Silva, Janaina Pereira da

; Pádua, Adriana Ignácio de

; Silva, Ruan Víctor dos Santos

; Santos, Felipe Lima dos

; Oliveira, Poliana Silva de

; Araujo-Betetti, Priscila Norié

; Thievenaz, Joris

; Fortuna, Cinira Magali

Revista Brasileira de Enfermagem

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2024, Volume 77 Supl. 2 elocation e20230537

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: avaliar o risco relativo de abandono do tratamento do tabagismo durante sua fase intensiva. Métodos: estudo de coorte retrospectivo e quantitativo, desenvolvido a partir da consulta aos prontuários eletrônicos de pessoas que iniciaram o tratamento do tabagismo entre os anos de 2015 e 2019 em um ambulatório de especialidades de uma cidade do interior de São Paulo, Brasil. O risco relativo de abandonar o tratamento foi calculado utilizando o modelo de regressão de Poisson. Resultados: observou-se que, das 396 (100,0%) pessoas que iniciaram o tratamento, 109 (27,5%) o abandonaram antes do término da fase intensiva. A cada um ano de aumento na idade, o risco de abandono do tratamento do tabagismo diminuiu, em média, 2%. Conclusões: o risco de abandono do tratamento do tabagismo é maior em pessoas mais jovens. Faz-se necessário repensar o cuidado ofertado a adultos mais jovens, de forma a favorecer a continuidade do tratamento. Objetivos intensiva Métodos quantitativo 201 Paulo Brasil Poisson Resultados observouse observou se 39 100,0% 1000 100 0 (100,0% 10 27,5% 275 27 5 (27,5% idade diminuiu média 2 2% Conclusões jovens Fazse Faz 20 3 100,0 (100,0 1 27,5 (27,5 100, (100, 27, (27, (100 (27 (10 (2 (1 (

ABSTRACT Objectives: to evaluate the relative risk of smoking cessation treatment dropout during its intensive phase. Methods: a retrospective and quantitative cohort study was developed from the electronic medical records of individuals who started smoking cessation treatment between 2015 and 2019 at a specialty clinic in a city in the interior of São Paulo, Brazil. The relative risk of dropping out of treatment was calculated using the Poisson regression model. Results: it was observed that out of the 396 (100.0%) individuals who started the treatment, 109 (27.5%) abandoned it before the end of the intensive phase. For each one-year increase in age, the risk of dropping out of smoking cessation treatment decreased by an average of 2%. Conclusions: the risk of dropping out of smoking cessation treatment is higher among younger individuals. It is necessary to rethink the care offered to younger adults to promote the continuity of treatment. Objectives phase Methods 201 Paulo Brazil model Results 39 100.0% 1000 100 0 (100.0% 10 27.5% 275 27 5 (27.5% oneyear one year age 2 2% Conclusions 20 3 100.0 (100.0 1 27.5 (27.5 100. (100. 27. (27. (100 (27 (10 (2 (1 (

RESUMEN Objetivos: evaluar el riesgo relativo de abandono del tratamiento para dejar de fumar durante su fase intensiva. Métodos: un estudio de cohorte retrospectivo y cuantitativo se desarrolló a partir de los registros médicos electrónicos de individuos que comenzaron el tratamiento para dejar de fumar entre 2015 y 2019 en una clínica de especialidades en una ciudad del interior de São Paulo, Brasil. El riesgo relativo de abandonar el tratamiento se calculó utilizando el modelo de regresión de Poisson. Resultados: se observó que, de los 396 (100.0%) individuos que iniciaron el tratamiento, 109 (27.5%) lo abandonaron antes del final de la fase intensiva. Por cada aumento de un año en la edad, el riesgo de abandonar el tratamiento para dejar de fumar disminuyó en un promedio del 2%. Conclusiones: el riesgo de abandonar el tratamiento para dejar de fumar es mayor entre los individuos más jóvenes. Es necesario repensar el cuidado ofrecido a los adultos más jóvenes para promover la continuidad del tratamiento. Objetivos intensiva Métodos 201 Paulo Brasil Poisson Resultados 39 100.0% 1000 100 0 (100.0% 10 27.5% 275 27 5 (27.5% edad 2 2% Conclusiones 20 3 100.0 (100.0 1 27.5 (27.5 100. (100. 27. (27. (100 (27 (10 (2 (1 (

https://doi.org/10.1590/0034-7167-2023-0537

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