Species from Pavonia genus (Malvaceae) are traditionally used as antioxidant, n anti inflammatory and antimicrobial remedies. Previous studies have revealed their diversity of specialized metabolites widely used in the development of new medicines. This is the first study on Pavonia glazioviana Gurke, a Brazilian species known as “Malva da Chapada”. The research led to identify fifteen compounds: 132 (S) hydroxy pheophytin a; and 132(S) hydroxy 173 ethoxyphaeophorbide, n decanol, cycloart 23Z ene 3β,25 diol, cycloart 24S 25 ene 3β,24 diol, sitosterol 3 O β D glucopyranoside, stigmasterol 3 O β D glucopyranoside, quercetin, acacetin, kaempferol, tiliroside, 5 hydroxy 3,7,8,4’ tetramethoxyflavone, 5,7 dihydroxy 3,8,4’ trimethoxyflavone, 5,7 dihydroxy 4’ methoxyflavone, 5,7,4’ trihydroxy 3,8 dimethoxyflavone and 5,7,4’ trihydroxy 3 methoxyflavone. The major flavonoids were tested for their antimicrobial activity, and the compound 5,7 dihydroxy 3,8,4’ trimethoxyflavone showed strong activity against Escherichia coli (MIC = 512 μg mL1), Pseudomonas aeruginosa (MIC = 512 μg mL1), Candida albicans (MIC = 512 μg mL1), Candida tropicalis (MIC = 512 μg mL1), Candida parapsilosis (MIC = 512 μg mL1), Aspergillus flavus (MIC = 512 μg mL1) and A. fumigantus (MIC = 512 μg mL1). The total phenolic content, flavonoid content, and radical scavenging potential were determined showing its great production of phenolics and flavonoids, along with interesting radical scavenging potential (DPPH EC50 = 6.36 ± 0.029 mg mL 1). Our findings contributed to characterize P. glazioviana as a source of methoxylated flavonoids with antimicrobial potential. Malvaceae (Malvaceae antioxidant remedies medicines Gurke Malva Chapada. Chapada . Chapada” compounds 13 S (S 132S 132(S 17 ethoxyphaeophorbide decanol Z 3β25 3β 3β,2 diol 2 3β24 24 glucopyranoside quercetin acacetin kaempferol tiliroside 3,7,8,4 3784 7 8 4 tetramethoxyflavone 57 5, 3,8,4 384 methoxyflavone 5,7,4 574 38 3, MIC 51 mL1, mL1 , A mL1. content DPPH EC EC5 636 6 36 6.3 0029 0 029 0.02 1. 1 1) P 3β2 3β, 3,7,8, 378 3,8, 5,7, 63 6. 002 02 0.0 3,7,8 37 00 0. 3,7, 3,7

Introduction The hemogram and hemogram-derivative ratios (HDRs) are becoming markers of the severity and mortality of COVID-19. We evaluated the hemograms and serial weekly HDRs [neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), neutrophil-platelet ratio (NPR) and systemic immune-inflammatory index (SII)] in the survivors and non-survivors of COVID-19. Methods We retrospectively reviewed the medical notes and serial hemograms of real-time reverse-transcription polymerase chain reaction (RT-PCR)-confirmed COVID-19 adults hospitalized from April 2020 to March 2021 from the time of diagnosis to the 3rd week of diagnosis. Results Of the 320 adults, 257 (80.3%) were survivors and had a lower mean age than the non-survivors (57.73 vs. 64.65 years, p < 0.001). At diagnosis, the non-survivors had lower hematocrit (p = 0.021), and lymphocyte (p = 0.002) and basophil (p = 0.049) counts and the hematocrit showed a p-value (Is this what you meant???) of 0.021); higher NLR (p < 0.001), PLR (p = 0.047), NPR (p = 0.022) and SII (p = 0.022). Using general linear models, the survivors and non-survivors showed significant variations with weekly lymphocyte count (p < 0.001), neutrophil count (p = 0.005), NLR (p = 0.009), MLR (p = 0.010) and PLR (p = 0.035). All HDRs remained higher in the non-survivors in the 2nd week and 3rd week of diagnosis and the HDRs were higher in the intubated patients than in the non-intubated patients. The NLR and SII were more efficient predictors of mortality in COVID-19 patients. Conclusions This study shows that serial lymphocyte and neutrophil counts, NLR, PLR, MLR, NPR and SII could serve as good and easily accessible markers of severity and predictors of outcomes in COVID-19 patients and should be used for the monitoring of treatment response. hemogramderivative derivative (HDRs COVID19. COVID19 COVID 19. 19 neutrophillymphocyte , (NLR) monocytelymphocyte monocyte (MLR) plateletlymphocyte platelet (PLR) neutrophilplatelet (NPR immuneinflammatory immune inflammatory (SII) nonsurvivors non realtime real reversetranscription reverse transcription RTPCRconfirmed RT PCR confirmed COVID-1 202 rd 32 25 80.3% 803 80 3 (80.3% 57.73 5773 57 73 (57.7 vs 6465 64 65 64.6 years 0.001. 0001 0.001 . 0 001 0.001) 0.021, 0021 0.021 021 0.021) 0.002 0002 002 0.049 0049 049 pvalue value Is meant meant??? 0.001, 0.047, 0047 0.047 047 0.047) 0.022 0022 022 0.022. models 0.005, 0005 0.005 005 0.005) 0.009, 0009 0.009 009 0.009) 0.010 0010 010 0.035. 0035 0.035 035 0.035) nd nonintubated response COVID1 1 (NLR (MLR (PLR (SII COVID- 20 2 80.3 8 (80.3 57.7 577 5 7 (57. 646 6 64. 000 0.00 00 0.02 02 0.04 004 04 meant?? 0.01 01 003 0.03 03 80. (80. 57. (57 0.0 meant? (80 (5 0. (8 (

ABSTRACT Objective: To evaluate the frequency of obesity and cardiometabolic risk in schoolchildren under ten years old. Methods: This is a cross-sectional study with schoolchildren (n=639) aged five to ten years in a municipally of southern of Brazil. The cardiometabolic risk was calculated from values of body mass index (BMI), waist circumference (WC), diastolic (DBP) and systolic blood pressure (SBP), blood glucose levels, triglycerides and total cholesterol (TC). Odds ratio (OR), Spearman correlation and principal component analysis (PCA) were analyzed. Results: Independent of sex, elevated WC and BMI were related to higher values of SBP, DBP, and TC in schoolchildren. The frequency of cardiometabolic risk was 6.0% in girls and 9.9% in boys. Schoolchildren with elevated values of SBP, triglycerides and TC presented high OR for cardiometabolic risk. PCA indicated that schoolchildren with high WC (p>80) presented more frequently altered glucose levels, triglycerides, and TC. Conclusions: Obesity, especially when associated with elevated WC, is related to metabolic dysfunctions and cardiometabolic risk in schoolchildren under ten years of age. These findings indicate the urgency of stablishing metabolic risk for this age group, enabling early diagnosis and adequate treatment, to prevent the development of diabetes and cardiovascular dysfunction throughout life. Objective old Methods crosssectional cross sectional n=639 n639 n 639 (n=639 Brazil BMI, , (BMI) (WC) DBP (DBP SBP (SBP) levels . (TC) OR, (OR) (PCA analyzed Results sex 60 6 0 6.0 99 9 9.9 boys p>80 p80 p 80 (p>80 Conclusions Obesity group treatment life n=63 n63 63 (n=63 (BMI (WC (SBP (TC (OR 6. 9. p>8 p8 8 (p>8 n=6 n6 (n=6 p> (p> n= (n= (p (n

RESUMO Objetivo: Avaliar a frequência de obesidade e risco cardiometabólico em escolares menores de dez anos de idade. Métodos: Este é um estudo transversal com escolares (n=639) com idade de cinco a dez anos de um município do Sul do Brasil. O risco cardiometabólico foi calculado com base nos valores do índice de massa corpórea (IMC), circunferência da cintura (CC), pressão arterial sistólica (PAS) e diastólica (PAD), valores sanguíneos de glicose, triglicerídeos e colesterol total. Odds ratio (OR), correlação de Spearman e análise de componentes principais (PCA) foram obtidos. Resultados: Independentemente do sexo, CC e IMC aumentados foram relacionados com maiores valores de PAS, PAD e colesterol total. A frequência de risco cardiometabólico foi de 6,0% nas meninas e 9,9% nos meninos. Escolares com elevados valores de PAS, triglicerídeos e colesterol total tinham alto OR para risco cardiometabólico. A PCA mostrou que escolares com alta CC (p>80) apresentam mais frequentemente alterações nos níveis sanguíneos de glicose, triglicerídeos e colesterol total. Conclusões: A obesidade, especialmente quando associada a elevados valores de CC, está relacionada com disfunções metabólicas e risco cardiometabólico em escolares menores de dez anos de idade. Estes achados indicam a urgência de estabelecer o risco metabólico para essa faixa etária, possibilitando o diagnóstico precoce, o adequado tratamento para evitar o desenvolvimento de diabetes e disfunções cardiovasculares ao longo da vida. Objetivo Métodos n=639 n639 n 639 (n=639 Brasil IMC, , (IMC) (CC) PAS (PAS PAD, (PAD) glicose OR, (OR) (PCA obtidos Resultados sexo 60 6 0 6,0 99 9 9,9 meninos p>80 p80 p 80 (p>80 Conclusões etária precoce vida n=63 n63 63 (n=63 (IMC (CC (PAD (OR 6, 9, p>8 p8 8 (p>8 n=6 n6 (n=6 p> (p> n= (n= (p (n

ABSTRACT Conditions related to the acquired immune deficiency syndrome (AIDS) are still a significant cause of morbidity and mortality among people living with HIV (PLHIV). Longer survival in this population were reported to increase the risk of developing noncommunicable chronic diseases (NCDs). This study aimed to estimate the survival and causes of death according to age group and sex among PLHIV monitored at two referral centers in the Northeastern Brazil. This is a prospective, retrospective cohort with death records from 2007 to 2018, based on a database that registers causes of death using the International Classification of Disease (ICD-10), which were subsequently coded following the Coding Causes of Death in HIV (CoDe). A total of 2,359 PLHIV participated in the study, with 63.2% being men, with a follow-up period of 13.9 years. Annual mortality rate was 1.46 deaths per 100 PLHIV (95% CI: 1.33 – 1.60) with a frequency of 20.9%. Risk of death for men increased by 49% when compared to women, and the risk of death in PLHIV increased by 51% among those aged 50 years and over at the time of diagnosis. It was observed that 73.5% accounted for AIDS-related deaths, 6.9% for non-AIDS defining cancer, 6.3% for external causes, and 3.2% for cardiovascular diseases. Among the youngest, 97.2% presented an AIDS-related cause of death. Highest frequency of deaths from neoplasms was among women and from external causes among men. There is a need for health services to implement strategies ensuring greater adherence to treatment, especially among men and young people. Moreover, screening for chronic diseases and cancer is essential, including the establishment of easily accessible multidisciplinary care centers that can identify and address habits such as illicit drug use and alcoholism, which are associated with violent deaths. AIDS (AIDS PLHIV. . (PLHIV) NCDs. NCDs (NCDs) Brazil prospective 200 2018 ICD10, ICD10 ICD 10 , (ICD-10) CoDe. CoDe (CoDe) 2359 2 359 2,35 632 63 63.2 followup follow up 139 13 9 13. 146 1 46 1.4 95% 95 (95 CI 133 33 1.3 1.60 160 60 209 20 20.9% 49 51 5 diagnosis 735 73 73.5 AIDSrelated 69 6 6.9 nonAIDS non 3 6.3 32 3.2 youngest 972 97 97.2 treatment Moreover essential alcoholism (PLHIV (NCDs 201 ICD1 (ICD-10 (CoDe 235 35 2,3 63. 14 4 1. (9 1.6 16 20.9 7 73. 6. 3. 97. (ICD-1 23 2, ( 20. (ICD- (ICD

Stemodin (1) is a diterpene produced by Stemodia maritima L. (Scrophulariaceae) and shows antiviral and tumor cell proliferation inhibitory activities. Chemical modifications of 1 were performed to produce the known stemodinone (2), two new stemodinone oximes, Z (3) and E (4), and seven new oxime esters derivatives (5, 6, 7, 8, 9, 10, and 11). All derivatives were evaluated for their cytotoxic activity in HL60 (promyelocytic leukemia), SNB-19 (astrocytoma), HCT-116 (colon carcinoma), and PC3 (prostate) human cancer cell lines, and L929 (healthy murine cells). Oximes 3 and 4 showed lower cytotoxic values than 1 against all cancer cell lines tested. However, esters 9 and 10 exhibited cell growth inhibition percentages higher than 1 against PC3, SNB-19, and HCT-116 cancer cell lines, ranging from 62.96 to 94.27%. Many of these values exceed that presented by doxorubicin (66.05-86.87%). All compounds showed no cytotoxic effect on healthy cells at the tested concentration of 25 µg mL-1. (1 L Scrophulariaceae (Scrophulariaceae activities 2, 2 , (2) oximes (3 4, (4) 5, 5 (5 6 7 8 11. 11 . 11) HL HL6 promyelocytic leukemia, leukemia leukemia) SNB19 SNB 19 SNB-1 astrocytoma, astrocytoma (astrocytoma) HCT116 HCT 116 HCT-11 colon carcinoma, carcinoma carcinoma) PC prostate (prostate L92 cells. cells) However SNB19, 19, 6296 62 96 62.9 9427 94 27 94.27% 66.0586.87%. 66058687 66.05 86.87% 66 05 86 87 (66.05-86.87%) mL1. mL1 mL 1. mL-1 ( (2 (4 SNB1 SNB- (astrocytoma HCT11 HCT-1 L9 629 62. 942 94.27 0586 66.0586.87% 6605868 6605 66.0 8687 86.87 0 (66.05-86.87% mL- HCT1 HCT- 94.2 058 66.0586.87 660586 660 66. 868 86.8 (66.05-86.87 94. 66.0586.8 66058 86. (66.05-86.8 66.0586. (66.05-86. 66.0586 (66.05-86 66.058 (66.05-8 (66.05- (66.05 (66.0 (66. (66 (6

ABSTRACT Wild birds have great prominence in the transmission of diseases to humans, mainly due to their ease of access to human populations, raising concerns about the potential impact of that proximity on public health. The present study reports ARV and PBV occurrence in wild birds from an environmental protection area in the Amazon biome, in Pará state, Brazil. We obtained 155 fecal specimens from 47 species of wild birds for RNA extraction, ARV and PBV detection utilizing molecular methods, nucleotide sequencing, and phylogenetic analysis. ARV prevalence was 0.6% (1/155), being positive in an individual of Myrmotherula longipennis, and PBV prevalence was 1.29% (2/155), affecting two individuals of Guira guira. The PBV strains were assigned to genogroup I based on phylogenetic analysis, and they shared a strong phylogenetic link with strains isolated from different geographic locations. The ARV strain was more closely related to strains that had previously circulated in the same region. The presence of ARV and PBV in this habitat suggests that infection cycles of these agents occur naturally in the wild ecosystem, potentially triggering transmission events between bird species and humans. This is the first study on ARV detection in wild birds in Brazil and the first report on the occurrence of PBV in wild Guira guira. Additional studies are required to determine the epidemiology, origin, evolution, and emergence of new potentially pathogenic viruses in the Amazon. humans populations health biome state 15 4 extraction methods sequencing analysis 06 0 6 0.6 1/155, 1155 1/155 , 1 (1/155) longipennis 129 29 1.29 2/155, 2155 2/155 2 (2/155) guira locations region ecosystem epidemiology origin evolution 0. 115 1/15 (1/155 12 1.2 215 2/15 (2/155 11 1/1 (1/15 1. 21 2/1 (2/15 1/ (1/1 2/ (2/1 (1/ (2/ (1 (2 (

RESUMO As aves silvestres têm grande destaque na transmissão de doenças ao homem, principalmente pela facilidade de acesso à população humana, levantando preocupações sobre o potencial impacto dessa proximidade no contexto da saúde pública. O presente estudo relata a ocorrência de ARV e PBV em aves silvestres de uma área de proteção ambiental no bioma Amazônico. Obtivemos 155 espécimes fecais de 47 espécies de aves silvestres, que foram submetidos a extração de RNA, detecção de ARV e PBV por técnicas moleculares, sequenciamento nucleotídico e análise filogenética. A prevalência de infecção por ARV foi 0,6% (1/155), sendo positivo em um indivíduo de Myrmotherula longipennis, e a prevalência de PBV foi 1,29% (2/155), afetando dois insdivíduos de Guira guira. A análise filogenética agrupou as cepas de PBV no genogrupo I, mostrando intensa relação filogenética com cepas isoladas de outras regiões geográficas. A cepa de ARV esteve mais relacionada filogeneticamente a cepas previamente circulantes na mesma região. Este é o primeiro estudo sobre detecção de ARV em aves silvestres no Brasil e o primeiro relato sobre a ocorrência de PBV em Guira guira. A circulação de ARV e PBV nesse ambiente demonstra que os ciclos desses agentes estão ocorrendo de forma natural no ecossistema silvestre, o que pode desencadear possíveis eventos de transmissão entre as espécies aviárias e humanos. Estudos adicionais são necessários para determinar a epidemiologia, origem, evolução e surgimento de novos vírus potencialmente patogênicos na Amazônia. homem humana pública Amazônico 15 4 RNA moleculares 06 0 6 0,6 1/155, 1155 1/155 , 1 (1/155) longipennis 129 29 1,29 2/155, 2155 2/155 2 (2/155) guira I geográficas região silvestre humanos epidemiologia origem Amazônia 0, 115 1/15 (1/155 12 1,2 215 2/15 (2/155 11 1/1 (1/15 1, 21 2/1 (2/15 1/ (1/1 2/ (2/1 (1/ (2/ (1 (2 (

Abstract Background Enteropathic spondyloarthritis is underdiagnosed and inflammatory biomarkers and ultrasonography (US) could be useful for screening inflammatory bowel disease (IBD) patients. The objective of this study was to evaluate the prevalence of spondyloarthritis (SpA) in IBD patients, according to the Assessment of SpondyloArthritis International Society (ASAS) criteria and the correlation of results of US of entheses and joints with plasma calprotectin levels. Methods This was an observational cross-sectional study. Patients from the IBD outpatient clinic of a reference center were evaluated according to ASAS criteria classification, results of US of entheses and joints, and inflammatory biomarker measurements (erythrocyte sedimentation rates, C-reactive protein levels, fecal and plasma calprotectin levels). A p value lower than 0.05 was considered significant. Results A total of 30.5% of the studied sample (n = 118) of patients with IBD presented at least one inflammatory musculoskeletal manifestation. The overall prevalence of enteropathic SpA was 13.55%, with 10.16% axial SpA and 4.23% peripheral SpA according to the ASAS criteria. A total of 42.1% of patients had an MASEI score greater than 18, 35.2% had synovitis, and 14.7% had tenosynovitis on US, increasing the frequency of diagnosis of entero- pathic SpA to 22.8%. Plasma calprotectin levels were similar to those in healthy controls, and correlated only with the fecal calprotectin level (p 0.041). Conclusions A total of 13.5% of patients met the criteria in accordance with the ASAS criteria for enteropathic SpA, which increased to 22.8% with the addition of US. The prevalence of enthesitis, synovitis and tenosynovitis by US of symptomatic joints and entheses were 42%, 35% and 14.7% respectively. Plasma calprotectin was correlated with fecal calprotectin but not with inflammatory biomarkers or US or ASAS criteria. (US (IBD (SpA (ASAS crosssectional cross sectional classification erythrocyte rates Creactive C reactive . levels) 005 0 05 0.0 significant 305 30 5 30.5 n 118 manifestation 1355 13 55 13.55% 1016 10 16 10.16 423 4 23 4.23 421 42 1 42.1 18 352 35 2 35.2 147 14 7 14.7 entero 228 22 8 controls 0.041. 0041 0.041 041 0.041) 135 13.5 22.8 enthesitis 42% respectively 00 0. 3 30. 11 13.55 101 10.1 4.2 42. 35. 14. 004 0.04 04 13. 22. 10. 4.

Abstract One of the most widespread applications of poly(lactic acid) (PLA) is as a raw material in the form of filaments for 3D printing. To improve final disposal alternatives and minimize their effects on the environment, the aim of this study is to determine the biodegradability of 3D-printed PLA waste composted in a landfill with leachate soil and garden soil for 90 days and 180 days. The soil characteristics and material properties were evaluated by laboratory analyses. Changes in soil chemical composition and the loss of microorganisms were recorded. The thermal and mechanical properties of PLA did not change significantly, but fungal colonies, encrustation, and changes in the original colour were found, indicating the onset of surface biodegradation of the samples. Controlled conditions or longer periods would be needed to maintain an ecosystem favourable to biodegradation; otherwise, PLA could accumulate in the environment, causing future pollution problems. polylactic poly lactic acid (PLA D printing environment 3Dprinted Dprinted printed 9 18 analyses recorded significantly colonies encrustation found samples otherwise problems 1

RESUMO JUSTIFICATIVA E OBJETIVOS: Recém-nascidos saudáveis são submetidos a procedimentos dolorosos desde as primeiras horas de vida e a avaliação da dor é essencial para escolha do tratamento adequado. O objetivo deste estudo foi avaliar a concordância entre pesquisadores da escala Neonatal Facial Coding System (NFCS) antes, durante e após a vacinação contra hepatite B nas primeiras 48 horas de vida de recém-nascidos saudáveis. MÉTODOS: Trata-se de uma análise de concordância entre pesquisadores, realizada como um estudo de intervenção quase-experimental, desenvolvido em uma maternidade pública de Belo Horizonte. Dois pesquisadores procederam a avaliação independente a partir de filmagens 2 minutos antes, durante e 2 minutos após o procedimento. RESULTADOS: Foram incluídos 129 recém-nascidos entre agosto e dezembro de 2022, sendo 60 (46,51%) no grupo controle (contenção facilitada) e 69 (53,49%) no grupo intervenção (amamentação). Observou-se concordância substancial entre os pesquisadores antes (0,69) e após (0,70) a vacinação. Quando analisada concordância entre os grupos, ela foi substancial para as avaliações de recém-nascidos submetidos à contenção facilitada antes e após o procedimento. No grupo submetido à amamentação, a concordância foi quase perfeita antes e substancial depois do procedimento. CONCLUSÃO: Há concordância substancial entre os pesquisadores que utilizaram a escala NFCS antes, durante e após a vacinação. Este dado valida a utilização das escalas durante a avaliação da dor de recém-nascidos submetidos à contenção facilitada e amamentação, mesmo tratando-se de um método indireto de avaliação. É importante destacar a importância de programas periódicos de capacitação da equipe para utilização de escalas de avaliação da dor à beira leito. OBJETIVOS Recémnascidos Recém nascidos adequado (NFCS 4 recémnascidos recém MÉTODOS Tratase Trata se quaseexperimental, quaseexperimental experimental, experimental quase-experimental Horizonte procedimento RESULTADOS 12 2022 6 46,51% 4651 46 51 (46,51% 53,49% 5349 53 49 (53,49% amamentação. amamentação . (amamentação) Observouse Observou 0,69 069 0 (0,69 0,70 070 70 (0,70 grupos CONCLUSÃO tratandose tratando leito 1 202 46,51 465 5 (46,51 53,49 534 (53,49 (amamentação 0,6 06 (0,6 0,7 07 7 (0,7 20 46,5 (46,5 53,4 (53,4 0, (0, 46, (46, 53, (53, (0 (46 (53 ( (4 (5

ABSTRACT BACKGROUND AND OBJECTIVES: Healthy newborns inevitably undergo painful procedures from the first hours of life and pain assessment is essential for choosing the right treatment. The objective of this study was to evaluate the agreement between evaluators of the Neonatal Facial Coding System (NFCS) pain scale in healthy newborns before, during and after hepatitis B vaccination performed in the first 48 hours of life. METHODS: This is an analysis of agreement between two evaluators, carried out as part of a quasi-experimental intervention study, developed in a maternity hospital in Belo Horizonte. Two researchers carried out an independent evaluation based on filming 2 minutes before, during and 2 minutes after the procedure. RESULTS: The study included 129 newborns between August and December 2022, 60 (46.51%) in the control group (facilitated restraint) and 69 (53.49%) in the intervention group (breastfeeding). There was substantial agreement between the researchers before (0.69) and after (0.70) vaccination. When the agreement between the groups was analyzed, it was substantial for the evaluations of newborns submitted to facilitated restraint before and after the procedure. In the breastfeeding group, agreement was almost perfect before and substantial after the procedure. CONCLUSION: There was substantial agreement between the researchers who used the NFCS scale before, during and after vaccination. This data validates the use of the scales when assessing the pain of newborns undergoing easy restraint and breastfeeding, even though it is an indirect method of assessment. It is important to highlight the importance of periodic staff training programs for the use of pain assessment scales at bedside. OBJECTIVES treatment (NFCS 4 METHODS quasiexperimental quasi experimental Horizonte procedure RESULTS 12 2022 6 46.51% 4651 46 51 (46.51% 53.49% 5349 53 49 (53.49% breastfeeding. . (breastfeeding) 0.69 069 0 (0.69 0.70 070 70 (0.70 analyzed CONCLUSION bedside 1 202 46.51 465 5 (46.51 53.49 534 (53.49 (breastfeeding 0.6 06 (0.6 0.7 07 7 (0.7 20 46.5 (46.5 53.4 (53.4 0. (0. 46. (46. 53. (53. (0 (46 (53 ( (4 (5

RESUMEN Objetivo: Analizar los costos cognitivos producidos por el trabajo de los policías militares del estado de Rio de Janeiro. Método: Se trata de un estudio transversal con abordaje cuantitativo, realizado con 446 policías militares, de ambos sexos, distribuidos entre cuadros y oficiales, de los Batallones 7°, 15°, 20°, 24° y 41° de la Policía Militar. Se utilizó un instrumento para caracterizar las condiciones sociodemográficas, laborales, de estilo de vida y de salud, y una escala para evaluar el costo humano del trabajo, que analiza las exigencias del trabajo a través de los costos físicos, cognitivos y afectivos. Los datos fueron organizados, procesados y analizados utilizando el software Statistical Package for the Social Sciences (SPSS), versión 13.1. Resultados: El costo cognitivo presentó las medias más altas, con resultados graves (μ = 3,86; SD = 0,86), representando mayores exigencias en relación al costo humano del trabajo entre los policías militares del estado de Río de Janeiro y asociaciones significativas en relación a la obesidad, alteraciones cognitivas de atención y memoria, edad y horas de sueño. Conclusión: Al evaluar el coste humano del trabajo, el coste cognitivo fue el más exigente en el contexto laboral de los policías militares encuestados, presentando un grave riesgo de enfermedad. Objetivo Método cuantitativo 44 sexos oficiales 7 7° 15 15° 20 20° 24 41 Militar sociodemográficas laborales salud físicos afectivos organizados SPSS, SPSS , (SPSS) 131 13 1 13.1 Resultados altas μ 3,86 386 3 86 0,86, 086 0,86 0 0,86) obesidad memoria sueño Conclusión encuestados enfermedad 4 2 (SPSS 13. 3,8 38 8 08 0,8 3, 0,

ABSTRACT Objective: To assess the cognitive cost of work for military police officers in the state of Rio de Janeiro. Method: This is a cross-sectional study with a quantitative approach, carried out with 446 military police officers, of both sexes, distributed between non-commissioned officers and officers, in the 7th, 15th, 20th, 24th and 41st Military Police Battalions. An instrument was used to depict sociodemographic, work, lifestyle and health conditions and a scale for assessing the human cost of work, which analyses the demands of the job through physical, cognitive and affective costs. The data was organized, processed and analyzed using the Statistical Package for the Social Sciences (SPSS) software, version 13.1. Results: The cognitive cost had the highest means, with severe results (μ = 3.86; SD = 0.86), representing greater demands in relation to the human cost of work among military police officers in the state of Rio de Janeiro and significant associations in relation to obesity, cognitive alterations in attention and memory, age and hours of sleep. Conclusion: In assessing the human cost of work, the cognitive cost was the most demanding in the work context of the military police officers surveyed, presenting a serious risk of illness. Objective Method crosssectional cross sectional approach 44 sexes noncommissioned non commissioned 7th th 15th 20th st Battalions sociodemographic physical costs organized SPSS (SPSS software 131 13 1 13.1 Results means μ 3.86 386 3 86 0.86, 086 0.86 , 0 0.86) obesity memory sleep Conclusion surveyed illness 4 13. 3.8 38 8 08 0.8 3. 0.

RESUMO Objetivo: Analisar o custo cognitivo no trabalho dos policiais militares do estado do Rio de Janeiro. Método: Trata-se de um estudo de corte transversal com abordagem quantitativa, realizado com 446 policiais militares, de ambos os sexos, distribuídos entre praças e oficiais, nos 7°, 15°, 20°, 24° e 41° batalhões de Polícia Militar. Utilizou-se um instrumento para a caracterização sociodemográfica, laboral, hábitos de vida e condições de saúde e uma escala de avaliação do custo humano no trabalho, que analisa as exigências relativas ao trabalho por meio dos custos físico, cognitivo e afetivo. Os dados foram organizados, processados e analisados com o auxílio do programa Statistical Package for the Social Sciences (SPSS), versão 13.1. Resultados: O custo cognitivo apresentou as maiores médias, com resultados graves (μ = 3,86; DP = 0,86), representando maior exigência em relação ao custo humano no trabalho entre os policiais militares do estado do Rio de Janeiro e associações significativas em relação à obesidade, alterações cognitivas de atenção e memória, idade e horas de sono. Conclusão: Na avaliação do custo humano no trabalho, o custo cognitivo foi o mais exigido no contexto de trabalho dos policiais militares pesquisados apresentando um risco grave para o adoecimento. Objetivo Método Tratase Trata se quantitativa 44 sexos oficiais 7 7° 15 15° 20 20° 24 41 Militar Utilizouse Utilizou sociodemográfica laboral físico afetivo organizados SPSS, SPSS , (SPSS) 131 13 1 13.1 Resultados médias μ 3,86 386 3 86 0,86, 086 0,86 0 0,86) obesidade memória sono Conclusão adoecimento 4 2 (SPSS 13. 3,8 38 8 08 0,8 3, 0,

The publication Cardiovascular Statistics – Brazil aims to provide an annual compilation of data and research on the epidemiology of CVDs in Brazil.&nbsp; The report integrates official statistics from the Brazilian Ministry of Health and other governmental entities alongside data from the GBD project, coordinated by the IHME at the University of Washington. Additionally, it incorporates data derived from various sources and scientific studies, including cohorts and registries, that relate to CVDs and their associated risk factors. This publication is intended for a wide range of individuals, including researchers, clinicians, patients, healthcare policymakers, media professionals, the general public, and other interested parties seeking extensive national data about heart disease and stroke.&nbsp; Volunteer researchers from various Brazilian universities and research institutions carry out the project. The group is led by a five-member steering committee (ALPR, CAP, DCM, GMMO, and LCCB). The Brazilian Society of Cardiology fully supports this initiative, and the project receives collaborative support from the GBD Brazil Network and an International Committee (GAR, PP, and TAG) from both the IHME/University of Washington (GAR) and the World Heart Federation (PP and TAG).&nbsp;

A publicação Estatística Cardiovascular – Brasil tem por objetivo fornecer uma compilação anual dos dados e das pesquisas sobre a epidemiologia das DCV no Brasil.&nbsp; Este documento integra as estatísticas oficiais do Ministério da Saúde do Brasil e outras entidades governamentais ao lado de dados do projeto GBD, coordenado pelo IHME da Universidade de Washington. Além disso, incorpora dados derivados de várias fontes e estudos científicos, inclusive coortes e registros, relacionados às DCV e fatores de risco associados. Esta publicação destina-se a um público variado, incluindo pesquisadores, clínicos, pacientes, formuladores de políticas de saúde, profissionais da mídia, o público em geral e todos aqueles que buscam dados nacionais abrangentes sobre DCV e acidente vascular cerebral. Pesquisadores voluntários de várias universidades e instituições de pesquisa brasileiros realizaram este projeto. O grupo é liderado por um comitê diretivo com cinco membros (ALPR, CAP, DCM, GMMO e LCCB). A Sociedade Brasileira de Cardiologia apoia integralmente esta iniciativa e o projeto recebe colaboração da Rede GBD Brasil1 e do GBD International Committee (GAR, PP e TAG) do IHME/Universidade de Washington (GAR) e da World Heart Federation (PP e TAG).&nbsp;

Resumen Objetivo: evaluar la seguridad de los profesionales de enfermería y la cultura de seguridad del paciente durante su actuación profesional en el cuidado de pacientes sospechosos o con COVID-19. Método: estudio transversal realizado con 90 profesionales de unidades críticas de dos hospitales universitarios. Se utilizó un instrumento de caracterización sociodemográfica y de condiciones de salud, además de los constructos “Seguridad del profesional y del paciente” y Hospital Survey on Patient Safety Culture. Se realizaron análisis univariados entre el diagnóstico de COVID-19 y las características de los profesionales y se aplicó la correlación de Kendell entre los constructos. Resultados: el diagnóstico de COVID-19 mostró diferencia estadísticamente significativa entre los profesionales que actuaron por más de seis años en la unidad (p=0,020) y los ítems del constructo “Seguridad del profesional y del paciente” referentes a dudas sobre cómo retirar el Equipo de Protección Personal (p=0,013) y flujo seguro (p=0,021). Las dimensiones 2 (p=0,003), 3 (p=0,009), 4 (p=0,013), 6 (p<0,001) y 9 (p=0,024) del Hospital Survey on Patient Safety Culture se asociaron a la realización de formación. Conclusión: mayor tiempo de experiencia profesional de enfermería se asoció con la no infección por COVID-19. La percepción de la cultura de seguridad del paciente se relacionó con la realización de entrenamiento. Objetivo COVID19. COVID19 COVID 19. 19 Método universitarios salud Seguridad COVID-1 Resultados p=0,020 p0020 p 0 020 (p=0,020 p=0,013 p0013 013 (p=0,013 p=0,021. p0021 p=0,021 . 021 (p=0,021) p=0,003, p0003 p=0,003 , 003 (p=0,003) p=0,009, p0009 p=0,009 009 (p=0,009) p=0,013, p<0,001 p0001 001 (p<0,001 p=0,024 p0024 024 (p=0,024 formación Conclusión entrenamiento COVID1 1 COVID- p=0,02 p002 02 (p=0,02 p=0,01 p001 01 (p=0,01 (p=0,021 p000 p=0,00 00 (p=0,003 (p=0,009 p<0,00 (p<0,00 p=0,0 p00 (p=0,0 (p=0,00 p<0,0 (p<0,0 p=0, p0 (p=0, p<0, (p<0, p=0 (p=0 p<0 (p<0 p= (p= p< (p< (p

Abstract Objective: to evaluate nursing professionals and patient safety culture during the professional performance in the care of suspected or infected patients with COVID-19. Method: a cross-sectional study carried out with 90 professionals from critical care units of two teaching hospitals. An instrument for sociodemographic characterization and health conditions was used, in addition to the constructs “Nursing professional and patient safety” and the Hospital Survey on Patient Safety Culture. Univariate analyzes were performed between the diagnosis of COVID-19 and the characteristics of Nursing professionals, applying Kendell’s correlation between the constructs. Results: the COVID-19 diagnosis presented a significant statistical difference between nursing professionals that worked for more than six years at the critical care unit (p=0.020) and the items of the construct “Nursing professional and patient safety” regarding the doubts about how to remove the personal protective equipment (p=0.013) and safety flow (p=0,021). The dimensions 2 (p=0.003), 3 (p=0.009), 4 (p=0.013), 6 (p<0.001), and 9 (p=0.024) of the Hospital Survey on Patient Safety Culture were associated with the accomplishment of training. Conclusion: a higher professional nursing experience time was associated with non-infection by COVID-19. The perception of the safety culture of the patient was related to the accomplishment of training. Objective COVID19. COVID19 COVID 19. 19 Method crosssectional cross sectional hospitals used COVID-1 Kendells Kendell s Results p=0.020 p0020 p 0 020 (p=0.020 p=0.013 p0013 013 (p=0.013 p=0,021. p0021 p=0,021 . 021 (p=0,021) p=0.003, p0003 p=0.003 , 003 (p=0.003) p=0.009, p0009 p=0.009 009 (p=0.009) p=0.013, p<0.001, p0001 p<0.001 001 (p<0.001) p=0.024 p0024 024 (p=0.024 training Conclusion noninfection non infection COVID1 1 COVID- p=0.02 p002 02 (p=0.02 p=0.01 p001 01 (p=0.01 p=0,02 (p=0,021 p000 p=0.00 00 (p=0.003 (p=0.009 p<0.00 (p<0.001 p=0.0 p00 (p=0.0 p=0,0 (p=0,02 (p=0.00 p<0.0 (p<0.00 p=0. p0 (p=0. p=0, (p=0,0 p<0. (p<0.0 p=0 (p=0 (p=0, p<0 (p<0. p= (p= p< (p<0 (p (p<

Resumo Objetivo: avaliar a segurança dos profissionais de enfermagem e a cultura de segurança do paciente durante a atuação profissional no atendimento de pacientes suspeitos ou com COVID-19. Método: estudo transversal realizado com 90 profissionais de unidades críticas de dois hospitais-escola. Foi utilizado um instrumento para caracterização sociodemográfica e condições de saúde, além dos constructos “Segurança do profissional e do paciente” e Hospital Survey on Patient Safety Culture. Foram realizadas análises univariadas entre o diagnóstico de COVID-19 e as características dos profissionais, aplicando-se a correlação de Kendell entre os constructos. Resultados: o diagnóstico de COVID-19 apresentou diferença estatisticamente significativa entre os profissionais que trabalhavam há mais de seis anos na unidade (p=0,020) e os itens do constructo “Segurança do profissional e do paciente” referentes às dúvidas sobre como retirar o equipamento de proteção individual (p=0,013) e fluxo seguro (p=0,021). As dimensões 2 (p=0,003), 3 (p=0,009), 4 (p=0,013), 6 (p<0,001) e 9 (p=0,024) do Hospital Survey on Patient Safety Culture foram associadas à realização de treinamentos. Conclusão: maior tempo de experiência profissional do profissional de enfermagem esteve associado a não infecção por COVID-19. A percepção de cultura de segurança do paciente esteve relacionada à realização de treinamentos. Objetivo COVID19. COVID19 COVID 19. 19 Método hospitaisescola. hospitaisescola hospitais escola. escola hospitais-escola saúde Segurança COVID-1 aplicandose aplicando se Resultados p=0,020 p0020 p 0 020 (p=0,020 p=0,013 p0013 013 (p=0,013 p=0,021. p0021 p=0,021 . 021 (p=0,021) p=0,003, p0003 p=0,003 , 003 (p=0,003) p=0,009, p0009 p=0,009 009 (p=0,009) p=0,013, p<0,001 p0001 001 (p<0,001 p=0,024 p0024 024 (p=0,024 treinamentos Conclusão COVID1 1 COVID- p=0,02 p002 02 (p=0,02 p=0,01 p001 01 (p=0,01 (p=0,021 p000 p=0,00 00 (p=0,003 (p=0,009 p<0,00 (p<0,00 p=0,0 p00 (p=0,0 (p=0,00 p<0,0 (p<0,0 p=0, p0 (p=0, p<0, (p<0, p=0 (p=0 p<0 (p<0 p= (p= p< (p< (p

Resumo Introdução: no contexto atual do país, quanto mais a população envelhece, mais feminina se torna, fenômeno esse definido como a feminização da velhice. Em contrapartida a esta maior expectativa de vida, estudos apontam que, entre as pessoas idosas, as mulheres seriam mais vulneráveis e sofreriam mais violência do que os homens. Esse fato destaca a relevância em se considerar o gênero na temática de violência, haja vista a desigualdade presente nas relações sociais entre homens e mulheres. A violência contra as pessoas idosas em nosso país é considerado um problema de saúde pública, sendo que a Atenção Primária à Saúde por oferecer atendimento a maioria, é uma importante fonte de dados para o estudo. Objetivos: explorar a compreensão de mulheres idosas sobre a violência nesta faixa etária, visando a elaboração de estratégias de prevenção da violência para esta parcela da população. Métodos: pesquisa de campo qualitativa, fundamentada nos pressupostos da Hermenêutica - Dialética. Foram realizadas 40 entrevistas com mulheres acima de 60 anos de idade, em quatro unidades que compõem a Rede de Atenção Primária à Saúde. Os dados obtidos foram analisados à luz da Hermenêutica-Dialética. Resultados: emergiram três categorias analíticas: 1. Compreensão acerca da violência; 2. Visão da violência contra as mulheres idosas; 3. Sugestões de ações para evitar a violência contra a mulher idosa. Conclusões: foi possível apresentar a compreensão das mulheres idosas acerca da violência contra as idosas além de apreender de suas falas sugestões para evitar tal violação. Destaca-se que a temática violência contra a mulher idosa precisa ganhar mais espaço no campo da pesquisa e divulgação dos achados.

Abstract Introduction: in the current context of the country, the more the population grows old, the more feminine it becomes, a phenomenon known as the feminization of the old age. In contrast to this higher life expectancy, studies indicate that, among the elderly, women are more dependent and suffer more violence than men. This fact stands out as sacred when considering gender in the theme of violence, given the inequality present in social relations between men and women. Violence against the elderly is a public health problem in our country, and Primary Health Care, for offering care to the majority, is an important source of data for the study. Goals: explore the understanding of elderly women about violence in this age group, seeking to develop violence prevention strategies for this part of the population. Methods: qualitative field research, based on the assumptions of Hermeneutics - Dialectics. Forty interviews were conducted with women over 60 years of age old, in four units that make up the Primary Health Care Network. The data obtained were analyzed in the light of Hermeneutics-Dialectics. Results: three analytical categories emerged: 1. Understanding of violence; 2. Vision of violence against elderly women; 3. Suggestions for actions to prevent violence against elderly women. Conclusions: it was possible to present the understanding of elderly women about violence against elderly women, in addition to apprehending suggestions to avoid such violation from their speeches. It is noteworthy that thematic violence against elderly women needs to gain more space in the field of research and dissemination of findings.

Resumo Introdução: A educação na infância tem sido reconhecida como aspecto fundamental para o desenvolvimento global da criança, sendo a escola, o espaço onde se proporciona condições para ofertas pedagógicas intencionalmente planejadas, oferecendo condições para que as crianças exerçam o papel de ator social e sujeito de direitos. Nessa premissa, a documentação pedagógica, estratégia contemplada nas atuais pedagogias participativas, tem despontado como ferramenta relevante no cenário de Educação Infantil, sendo necessário apropriação prática para a obtenção de êxito nos resultados. Objetivo: Compreender essa centralidade de documentação pedagógica como estratégia contemplada para efetivação de pedagogias participativas na Educação Infantil, segundo a literatura sobre a temática. Método: Revisão de Literatura, realizada nas bases de dados Scientific Electronic Library Online (Scielo), Educational Resources Information Center (ERIC), Scopus e Google Acadêmico, no período que compreende entre outubro de 2022 e novembro de 2022. Resultados: Foram constituídas três bases analíticas, a saber: Uma prática investigativa, adocumentação pedagógica e a observação e os registros na documentação pedagógica. Considerações finais: Evidenciou-se que, na prática, a documentação pedagógica impacta em condições para a reflexão das crianças sobre suas vivências, impulsionando-as a se inserirem em atividades investigativas a partir de suas problematizações, durante o processo pedagógico na Educação Infantil e, como via de mão dupla, oferece condições para a autoformação dos professores e professoras, com ênfase na reflexão sobre as práticas docentes.

Abstract Introduction: Early childhood education has been recognized as a fundamental aspect for the overall development of the child, with the school being the space where conditions are provided for intentionally planned pedagogical offers, offering conditions for children to exercise the role of social actor and subject of rights. On this premise, pedagogical documentation, a strategy contemplated in current participatory pedagogies, has emerged as a relevant tool in the Early Childhood Education scenario, requiring practical appropriation to obtain successful results. Objective: To understand this centrality of pedagogical documentation as a contemplated strategy for implementing participatory pedagogies in Early Childhood Education, according to the literature on the subject. Method: Literature review, carried out in the Scientific Electronic Library Online (Scielo), Educational Resources Information Center (ERIC), Scopus and Google Scholar databases, in the period between October 2022 and November 2022. Results: Three analytical bases, namely: An investigative practice, pedagogical documentation and observation and records in pedagogical documentation. Final considerations: It was evidenced that, in practice, the pedagogical documentation impacts on conditions for children's reflection on their experiences, impelling them to be inserted in investigative activities based on their problematizations, during the pedagogical process in Early Childhood Education and, as a two-way street, it offers conditions for the self-training of male and female teachers, with an emphasis on reflection on teaching practices.