Abstract In Brazil, lima bean is mainly grown in the Northeast region, where it is widely consumed and is of major economic importance. We evaluated different Phaseolus lunatus accessions from the Northeast of Brazil using agromorphological markers and CMA/DAPI fluorochrome banding techniques. All the accessions showed CMA+ blocks of pericentromeric constitutive heterochromatin (CH). At least one pair of CMA++ terminal marks corresponds to the nucleolus organizer region (NORs). Characterization of the seeds suggests that the two Andean and Mesoamerican Phaseolus cultigroups are represented in the Brazilian germplasm analyzed. Most of them belong to the "Big Lima" group. Characterization studies of lima bean germplasm are important for increasing knowledge of the diversity and variability of the species and for generating useful information for breeding and conservation of this economically important legume. importance CMADAPI CMA DAPI techniques CH. CH . (CH) NORs. NORs (NORs) analyzed Big Lima group legume (CH (NORs

ABSTRACT Objectives: To analyze brain death (BD) notifications received by Central de Transplantes (CET) in the state of Roraima (RR) from 2017 to 2021. Methods: This is a cross-sectional, quantitative, and observational study, where all notifications received by CET from 2017 to 2021 were analyzed, resulting in 120 patients from health the following centers: Hospital Geral de Roraima (HGR), Hospital Confederação Nacional das Cooperativas Médicas (UNIMED), Hospital da Criança Santo Antônio (HCSA), Hospital das Clínicas (HC), and Hospital Lotty Íris (HLI). The data were collected from the center’s data management system and passed on to the collection form developed by the researcher. Results: This study analyzed 119 notifications after excluding one due to conflicting data. There was a predominance of males (58%), with traumatic brain injury being the most frequent cause of BD. Six organ harvestings were carried out, all at the HGR. This study found no significant associations between organ procurement and sex, age, place of hospitalization, and year. Conclusion: There are considerable challenges concerning organ donation in RR, with a low uptake rate over five years. Only the HGR successfully carried out organ harvesting, while other reporting hospitals were unsuccessful. Improvements are needed, highlighting the importance of more studies for a more in-depth data analysis. Objectives BD (BD (CET RR (RR 201 Methods crosssectional, crosssectional cross sectional, sectional cross-sectional quantitative 202 12 centers HGR, , (HGR) UNIMED, UNIMED (UNIMED) HCSA, HCSA (HCSA) HC, HC (HC) HLI. HLI . (HLI) center s researcher Results 11 58%, 58 58% (58%) sex age hospitalization year Conclusion years harvesting unsuccessful needed indepth depth analysis 20 1 (HGR (UNIMED (HCSA (HC (HLI 5 (58% 2 (58 (5 (

RESUMO Objetivos: Analisar as notificações de morte encefálica (ME) recebidas pela Central de Transplantes (CET) do estado de Roraima (RR) de 2017 a 2021. Métodos: Trata-se de estudo transversal, quantitativo e observacional no qual foram analisadas todas as notificações recebidas pela CET no período de 2017 a 2021, resultando em 120 pacientes, dos seguintes centros de saúde: Hospital Geral de Roraima (HGR), Hospital Confederação Nacional das Cooperativas Médicas (UNIMED), Hospital da Criança Santo Antônio (HCSA), Hospital das Clínicas (HC) e Hospital Lotty Íris (HLI). Os dados foram coletados do sistema de gerenciamento de dados da central e repassados para a ficha de coleta desenvolvida pela pesquisadora. Resultados: Este estudo analisou 119 notificações após a exclusão de uma devido a dados conflitantes. Houve predominância do sexo masculino (58%), com trauma cranioencefálico sendo a causa mais frequente de ME. Ao todo, foram realizadas seis captações de órgãos, todas no HGR. Este estudo não encontrou associações significativas entre a captação de órgãos e sexo, idade, local de internação e ano. Conclusão: Há grandes desafios em relação à doação de órgãos em RR, com uma taxa de captação baixa ao longo de 5 anos. Apenas o HGR obteve sucesso em realizar captações de órgãos, diferentemente de outros hospitais notificadores. São necessárias melhorias, destacando a importância de se realizarem mais estudos para uma análise mais aprofundada dos dados. Objetivos ME (ME (CET RR (RR 201 2021 Métodos Tratase Trata transversal 12 pacientes saúde HGR, , (HGR) UNIMED, UNIMED (UNIMED) HCSA, HCSA (HCSA) HC (HC HLI. HLI . (HLI) pesquisadora Resultados 11 conflitantes 58%, 58 58% (58%) todo idade ano Conclusão anos notificadores melhorias 20 202 1 (HGR (UNIMED (HCSA (HLI (58% 2 (58 (5 (

Abstract Chagas disease is a neglected parasitic disease caused by Trypanosoma cruzi, whose treatment has remained unsatisfactory for over 50 years, given that it is limited to two drugs. Benznidazole (BZN) is an efficient antichagasic drug used as the first choice, although its poor water-solubility, irregular oral absorption, low efficacy in the chronic phase, and various associated adverse effects are limiting factors for treatment. Incorporating drugs with such characteristics into nanostructured lipid carriers (NLC) is a promising alternative to overcome these limiting obstacles, enhancing drug efficacy and bioavailability while reducing toxicity. Therefore, this study proposed NLC-BZN formulations in different compositions prepared by hot-melt homogenization followed by ultrasound, and the optimized formulation was characterized by FTIR, DRX, DSC, and thermogravimetry. Biological activities included in vitro membrane toxicity (red blood cells), fibroblast cell cytotoxicity, and trypanocidal activity against epimastigotes of the Colombian strain of T. cruzi. The optimized NLC-BZN had a small size (110 nm), negative zeta potential (-18.0 mV), and high encapsulation (1.64% of drug loading), as shown by infrared spectroscopy, X-ray diffraction, and thermal analysis. The NLC-BZN also promoted lower in vitro membrane toxicity (<3% hemolysis), and 50% cytotoxic concentration (CC50) for NLC-BZN in L929 fibroblast cells (110.7 µg/mL) was twice the value as the free BZN (51.3 µg/mL). Our findings showed that the NLC-BZN had higher trypanocidal activity than free BZN against the epimastigotes of the resistant Colombian strain, and this novel NLC-BZN formulation proved to be a promising tool in treating Chagas disease and considered suitable for oral and parenteral administration. cruzi 5 years (BZN choice watersolubility, watersolubility water solubility, solubility water-solubility absorption phase NLC (NLC obstacles Therefore NLCBZN hotmelt hot melt ultrasound FTIR DRX DSC thermogravimetry red cells, , cells) cytotoxicity T 110 (11 nm, nm nm) 18.0 180 18 0 (-18. mV, mV mV) 1.64% 164 1 64 (1.64 loading, loading loading) spectroscopy Xray X ray diffraction analysis <3% 3 (<3 hemolysis, hemolysis hemolysis) CC50 CC (CC50 L L92 110.7 1107 7 (110. µg/mL µgmL µg mL 51.3 513 51 (51. µg/mL. . administration 11 (1 18. (-18 1.64 16 6 (1.6 <3 (< CC5 (CC5 L9 110. 51. (51 ( (-1 1.6 (1. < (CC (5 (- 1.

Abstract Paper aims Investigate whether the results of time series models can be adjusted with the AHP method towards a more assertive forecast. Originality Considering demand forecasting as a complex decision-making situation, this research investigated the use of the AHP as a complement to traditional forecasting methods. Research method This applied research employed, as main procedures, literature review and mathematical modeling. Main findings Two models were proposed that presented satisfactory results: model I reduced the forecast error by 16% in January, 25% in February, 37% in March, 3% in April, and 7% in May; model II reduced it by 17% in January, 21% in February, 29% in March, 2% in April, and 5% in May. Implications for theory and practice We conclude that the AHP has the potential to correct the results of time series in the textile industry by allowing the incorporation of quantitative and qualitative variables.

RESUMO Objetivo: Analisar o perfil epidemiológico da infecção pelo HIV em gestantes. Métodos: Estudo analítico com abordagem quantitativa. Resultados: A taxa de HIV em gestantes aumentou de 1,5 em 2010 para 3,3 casos/mil nascidos vivos em 2017. Verificou-se associação significante entre o prénatal e as variáveis escolaridade (p < 0,0001), ocupação (p = 0,0105), idade gestacional (p < 0,0001) e tipo de parto (p < 0,0001). A taxa média de adesão ao tratamento antirretroviral no pré-natal foi de 68,8% (DP = ± 3,7). Conclusão: As elevadas taxas de detecção de HIV em gestantes remetem à necessidade de intensificação do cuidado às mulheres durante o pré-natal, com garantia de integralidade da assistência, diagnóstico precoce e aprimoramento de estratégias para a melhoria da adesão ao tratamento antirretroviral visando à supressão viral materna no momento do parto e redução do risco de transmissão vertical.

ABSTRACT Objective: To analyze the epidemiological profile of HIV infections in pregnant women. Methods: Analytical study with a quantitative approach. Results: The HIV rate in pregnant women increased from 1.5/1000 babies born alive, in 2010, to 3.3/1000 in 2017. There was a significant association between the prenatal and the variables educational level (p<0.0001), occupation (p=0.0105), gestational age (p < 0.0001), and type of delivery (p < 0.0001). The mean rate of adherence to the antiretroviral treatment in the prenatal was 68.8% (DP = ± 3.7). Conclusion: The high rates of HIV detection in pregnant women suggest the need to intensify the health care to women during the prenatal, guaranteeing an integral care, early diagnoses, and enhancing the strategies to improve the adherence to the antiretroviral treatment, aiming to achieve the viral suppression of the mother by the time of childbirth, thus diminishing the risk of a vertical transmission.

RESUMEN Objetivo: Analizar el perfil epidemiológico de la infección por VIH en embarazadas. Métodos: Estudio analítico con abordaje cuantitativo. Resultados: La tasa de VIH en embarazadas aumentó de 1,5 en 2010 para 3,3 casos/mil nacidos vivos en 2017. Se verificó relación significante entre el prenatal y las variables escolaridad (p < 0,0001), ocupación (p = 0,0105), edad gestacional (p < 0,0001) y tipo de parto (p < 0,0001). La tasa media de adhesión al tratamiento antirretroviral en el prenatal fue de 68,8% (DP = ± 3,7). Conclusión: Las elevadas tasas de detección de VIH en embarazadas remiten a la necesidad de intensificación de la atención a las mujeres durante el prenatal, con garantía de integridad de la asistencia, diagnóstico precoz y perfeccionamiento de estrategias para la mejoría de la adhesión al tratamiento antirretroviral objetivando a la supresión viral materna en el momento del parto y reducción del riesgo de transmisión vertical.

ABSTRACT Objective: To analyze the epidemiological profile of HIV infections in pregnant women. Methods: Analytical study with a quantitative approach. Results: The HIV rate in pregnant women increased from 1.5/1000 babies born alive, in 2010, to 3.3/1000 in 2017. There was a significant association between the prenatal and the variables educational level (p<0.0001), occupation (p=0.0105), gestational age (p < 0.0001), and type of delivery (p < 0.0001). The mean rate of adherence to the antiretroviral treatment in the prenatal was 68.8% (DP = ± 3.7). Conclusion: The high rates of HIV detection in pregnant women suggest the need to intensify the health care to women during the prenatal, guaranteeing an integral care, early diagnoses, and enhancing the strategies to improve the adherence to the antiretroviral treatment, aiming to achieve the viral suppression of the mother by the time of childbirth, thus diminishing the risk of a vertical transmission.

RESUMEN Objetivo: Analizar el perfil epidemiológico de la infección por VIH en embarazadas. Métodos: Estudio analítico con abordaje cuantitativo. Resultados: La tasa de VIH en embarazadas aumentó de 1,5 en 2010 para 3,3 casos/mil nacidos vivos en 2017. Se verificó relación significante entre el prenatal y las variables escolaridad (p < 0,0001), ocupación (p = 0,0105), edad gestacional (p < 0,0001) y tipo de parto (p < 0,0001). La tasa media de adhesión al tratamiento antirretroviral en el prenatal fue de 68,8% (DP = ± 3,7). Conclusión: Las elevadas tasas de detección de VIH en embarazadas remiten a la necesidad de intensificación de la atención a las mujeres durante el prenatal, con garantía de integridad de la asistencia, diagnóstico precoz y perfeccionamiento de estrategias para la mejoría de la adhesión al tratamiento antirretroviral objetivando a la supresión viral materna en el momento del parto y reducción del riesgo de transmisión vertical.

RESUMO Objetivo: Analisar o perfil epidemiológico da infecção pelo HIV em gestantes. Métodos: Estudo analítico com abordagem quantitativa. Resultados: A taxa de HIV em gestantes aumentou de 1,5 em 2010 para 3,3 casos/mil nascidos vivos em 2017. Verificou-se associação significante entre o prénatal e as variáveis escolaridade (p < 0,0001), ocupação (p = 0,0105), idade gestacional (p < 0,0001) e tipo de parto (p < 0,0001). A taxa média de adesão ao tratamento antirretroviral no pré-natal foi de 68,8% (DP = ± 3,7). Conclusão: As elevadas taxas de detecção de HIV em gestantes remetem à necessidade de intensificação do cuidado às mulheres durante o pré-natal, com garantia de integralidade da assistência, diagnóstico precoce e aprimoramento de estratégias para a melhoria da adesão ao tratamento antirretroviral visando à supressão viral materna no momento do parto e redução do risco de transmissão vertical.

RESUMO Considerado fonte de proteína mais acessível à população, o feijão-comum é consumido diariamente, principalmente nos países em desenvolvimento, das regiões tropicais e subtropicais do planeta. Estudos que utilizam tanto descritores morfológicos quanto marcadores moleculares, vêm sendo utilizados em programas de melhoramento vegetal do feijoeiro. O presente artigo tem por objetivo reportar o estudo da diversidade de linhagens endogâmicas recombinantes e seus genitores utilizando descritores morfológicos e marcadores SSR. Foram avaliadas 22 linhagens recombinantes derivadas dos genitores BRS Agreste e a linhagem preto-01. Para a caracterização foram utilizados 18 marcadores microssatélites e os seguintes descritores morfológicos: presença de antocianina, número de dias após a germinação, dias para floração, cor da asa, cor do estandarte, cor da semente, cor do tegumento, brilho da semente, grupo comercial. Para caracterização molecular foram usados sete marcadores que apresentaram polimorfismo. Os valores de dissimilaridade, utilizando-se os dados morfológicos, variaram de 0 a 8.5; organizando as linhagens em três grupos distintos. Nas análises moleculares, dos 18 primers testados, 11 foram monomórficos e 7 apresentaram-se polimorfismo. Os valores de dissimilaridade para análise molecular variarando de 0 a 0.8; com média de 0.57. Além de informativos, esses marcadores estão associados a características importantes para o feijoeiro. A análise conjunta dos dados apresentou valores de dissimilaridade variando de 0.0 a 12.5, com média de 6.89, formando três grupos. A análise conjunta dos dados morfológicos e moleculares foi eficiente em caracterizar e distinguir as linhagens endogâmicas. Os marcadores moleculares utilizados mostraram-se adequados para o estudo realizado neste trabalho. As linhagens 18 e 19 podem ser consideradas duplicadas, pois na análise de diversidade obteve dissimilaridade zero.

ABSTRACT Considred a more accessible protein source for the population, common beans are consumed daily, mainly in developing countries, in the tropical and subtropical regions of the planet. Studies that use both morphological descriptors and molecular markers have been used in plant breeding programs for common beans. This article aims to report the study of the diversity of recombinant inbred lines and their parents using morphologial descriptors and SSR markers. 22 recombinant inbreeding lines were evaluated derived from the BRS Agreste parents and the black-01 line.For the characterization, 18 microsatellite markers and the following morphological descriptors were used: presence of anthocyanin, number of days after germination, days for flowering, wing color, standard color, seed color, tegument color, seed brightness, commercial group. For molecular characterization, seven markers were used that presented polymorphism The dissimilarity values, using morphological data, ranged from 0 to 8.5; organizing the lineages into three distinct groups. In the molecular analyzes, of the 18 primers tested, 11 were monomorphic and 7 presented polymorphism. The dissimilarity values for molecular analysis ranged from 0 to 0.8; with an average of 0.57. In addition to being informative, these markers are associated with important characteristics for common beans. Joint analysis of the data presented dissimilarity values ranging from 0.0 to 12.5, with an average of 6.89, forming three groups. The joint analysis of morphological and molecular data was efficient to characterize and distinguish inbred lines. The molecular markers used were suitable to the present study. The lines 18 and 19 can be considered duplicate because in all analyzes they remained together.

BACKGROUND The Yellow Fever (YF) vaccine is produced by the inoculation of embryonated chicken eggs with YF17DD virus on the ninth day of development. Full embryos are collected on the twelfth day of development for vaccine formulation. Skeletal muscle tissue is the main site where biosynthesis of viral particles occurs. OBJECTIVES This study aimed to analyse the experimental infection of skeletal muscle cells of chicken embryos by the 17DD Yellow Fever virus (YFV) in vivo and in vitro. METHODS Chicken embryos infected with YF17DD virus were analysed by immunofluorescence using confocal and super-resolution microscopes. Primary cultures of skeletal muscle cells of non-infected chicken embryos were evaluated for susceptibility and permissiveness to YF17DD virus using different protocols. This evaluation was performed based on morphological, viral titration, molecular biology, and colorimetric techniques. FINDINGS The present work phenotypically characterises embryonic chicken skeletal muscle cells as myogenic precursors expressing the Pax7 transcription factor in some cases. We demonstrated that these cells are susceptible to in vitro infection at different multiplicities of infection (MOIs), reproducing the same infection pattern observed in vivo. Furthermore, myogenic precursors and myoblasts are preferred infection targets, but establishment of infection does not depend on the presence of these cells. The peak of viral production occurred at 48 hpi, with decay occurring 72 hpi, when the cytopathic effect can be observed. MAIN CONCLUSIONS In conclusion, the primary culture of chicken skeletal muscle cells is a good model for studying muscle cells infected with YF17DD virus. This culture system displays satisfactory emulation of the in vitro phenomenon observed, contributing to our understanding of virus infection dynamics and leading to the development of alternative methods of vaccine production.

Resumo Para estudar os dados sobre tentativas de suicídio e mapear as áreas de incidência foi desenvolvido um estudo do tipo ecológico e exploratório, usando técnicas de geoprocessamento, com base em casos confirmados. Foram incluídos os casos de autoevenenamento, ocorridos na zona urbana do município de Campina Grande, para o período 2010-2013. Um total de 446 tentativas de suicídio foi georreferenciado, apontando uma incidência de 120 casos a cada 100.000 habitantes. A amostra foi majoritariamente feminina (66,4%), com 62,3% possuindo até 30 anos de idade. O mapa de Kernel evidenciou areas de hot spots. Populações dentro dos hot spots apresentaram um risco de suicídio 38% maior (Risco Relativo= 1,38; p = 0,0029), com uma estimativa média de 165 tentativas de suicídios por 100.000 habitantes. Através da identificação das áreas de hot spots e do índice de condições de vida dos bairros, pode-se estabelecer as prioridades em termos de políticas públicas de prevenção das tentativas de suicídio e de controle da comercialização de substâncias com potencial tóxico.

Abstract In order to study data about suicide attempts and do the mapping of occurrence areas, it was developed an ecologic and exploring study, making use of techniques of geoprocessing, based on confirmed cases of suicide attempts. Cases of self-poisoning were included in the urban area of Campina Grande county, in the period of 2010-2013. A total of 446 suicide attempts were geo-referred, pointing up an incidence of 120 cases out of each 100,000 inhabitants. The sample was mostly feminine (66.4%), and 62.3% being up to 30 years old. Kernel's map remarked hot spot areas. Compared to surrounding areas the suicide risk of populations within the hot spots was increased (38%; Relative Risk = 1.38; p= 0.0029), with an average estimative of 165 suicide attempts out of 100,000 inhabitants. Through identification of hot spots and index of living conditions of the neighborhoods, it is possible to set priorities in terms of public policies for the prevention of suicide attempts and control of the marketing of substances that are potentially toxic.

Resumo Para estudar os dados sobre tentativas de suicídio e mapear as áreas de incidência foi desenvolvido um estudo do tipo ecológico e exploratório, usando técnicas de geoprocessamento, com base em casos confirmados. Foram incluídos os casos de autoevenenamento, ocorridos na zona urbana do município de Campina Grande, para o período 2010-2013. Um total de 446 tentativas de suicídio foi georreferenciado, apontando uma incidência de 120 casos a cada 100.000 habitantes. A amostra foi majoritariamente feminina (66,4%), com 62,3% possuindo até 30 anos de idade. O mapa de Kernel evidenciou areas de hot spots. Populações dentro dos hot spots apresentaram um risco de suicídio 38% maior (Risco Relativo= 1,38; p = 0,0029), com uma estimativa média de 165 tentativas de suicídios por 100.000 habitantes. Através da identificação das áreas de hot spots e do índice de condições de vida dos bairros, pode-se estabelecer as prioridades em termos de políticas públicas de prevenção das tentativas de suicídio e de controle da comercialização de substâncias com potencial tóxico.

Abstract In order to study data about suicide attempts and do the mapping of occurrence areas, it was developed an ecologic and exploring study, making use of techniques of geoprocessing, based on confirmed cases of suicide attempts. Cases of self-poisoning were included in the urban area of Campina Grande county, in the period of 2010-2013. A total of 446 suicide attempts were geo-referred, pointing up an incidence of 120 cases out of each 100,000 inhabitants. The sample was mostly feminine (66.4%), and 62.3% being up to 30 years old. Kernel's map remarked hot spot areas. Compared to surrounding areas the suicide risk of populations within the hot spots was increased (38%; Relative Risk = 1.38; p= 0.0029), with an average estimative of 165 suicide attempts out of 100,000 inhabitants. Through identification of hot spots and index of living conditions of the neighborhoods, it is possible to set priorities in terms of public policies for the prevention of suicide attempts and control of the marketing of substances that are potentially toxic.

ABSTRACT Objective: To characterize the profile of users at risk of developing diabetes mellitus type 2 according to sociodemographic and clinical variables. Method: Cross-sectional study, descriptive, quantitative approach conducted with 266 users of Basic Care. Inferential statistics analysis, calculating the crude prevalence ratio with confidence interval of 95% and Kruskal-Wallis test, and application of the multivariate technique simple Correspondence Analysis. Results: It was noted that 83.1% were women and 36.4% frequented the Family Health Unit from 1 to 5 years. Regarding the factors associated with diabetes mellitus type 2, 66.5% of the users were overweight and 77.9% were rated with central obesity. The great majority, 77.4%, did not practice physical activities and 21.1% had altered glycemia. Conclusion: The results showed that many risk factors for developing diabetes mellitus type 2 were among the population of the study.

RESUMEN Objetivo: Caracterizar el perfil de usuarios en riesgo de desarrollar diabetes mellitus tipo 2 de acuerdo con las variables sociodemográficas y clínicas. Método: Estudio transversal, descriptivo, de abordaje cuantitativo realizado con 266 usuarios de la Atención Básica. Análisis estadístico inferencial, con el cálculo de las razones de prevalencias brutas con intervalo de confianza del 95% y la prueba de Kruskal-Wallis, y la aplicación de la técnica multivariada Análisis de Correspondencia simple. Resultados: Se constató que el 83,1% eran mujeres y el 36,4% frecuentaban la Unidad de Salud de la Familia de 1 a 5 años. Sobre los factores asociados a la diabetes mellitus tipo 2, el 66,5% de los usuarios estaba con sobrepeso; el 77,9% fue clasificado con obesidad central; la gran mayoría, el 77,4% no practicaba actividad física y el 21,1% tenía la glucemia alterada. Conclusión: Los resultados mostraron que diversos factores de riesgo para el desarrollo de la diabetes mellitus tipo 2 estuvieron presentes en la población del estudio.

RESUMO Objetivo: Caracterizar o perfil de usuários em risco de desenvolver diabetes mellitus tipo 2 de acordo com as variáveis sociodemográficas e clínicas. Método: Estudo transversal, descritivo, de abordagem quantitativa realizado com 266 usuários da Atenção Básica. Análise estatística inferencial, com o cálculo das razões de prevalências brutas com intervalo de confiança de 95% e o teste de Kruskal-Wallis e a aplicação da técnica multivariada Análise de Correspondência simples. Resultados: Constatou-se que 83,1% eram mulheres e 36,4% frequentavam a Unidade de Saúde da Família de 1 a 5 anos. Quanto aos fatores associados ao diabetes mellitus tipo 2, 66,5% dos usuários estavam com excesso de peso 77,9% foram classificados com obesidade central; a grande maioria, 77,4% não praticava exercício físico, 21,1% possuíam glicemia alterada. Conclusão: Os resultados mostraram que vários fatores de risco para o desenvolvimento do diabetes mellitus tipo 2 estiveram presentes na população do estudo.

RESUMO Objetivo: Caracterizar o perfil de usuários em risco de desenvolver diabetes mellitus tipo 2 de acordo com as variáveis sociodemográficas e clínicas. Método: Estudo transversal, descritivo, de abordagem quantitativa realizado com 266 usuários da Atenção Básica. Análise estatística inferencial, com o cálculo das razões de prevalências brutas com intervalo de confiança de 95% e o teste de Kruskal-Wallis e a aplicação da técnica multivariada Análise de Correspondência simples. Resultados: Constatou-se que 83,1% eram mulheres e 36,4% frequentavam a Unidade de Saúde da Família de 1 a 5 anos. Quanto aos fatores associados ao diabetes mellitus tipo 2, 66,5% dos usuários estavam com excesso de peso 77,9% foram classificados com obesidade central; a grande maioria, 77,4% não praticava exercício físico, 21,1% possuíam glicemia alterada. Conclusão: Os resultados mostraram que vários fatores de risco para o desenvolvimento do diabetes mellitus tipo 2 estiveram presentes na população do estudo.

ABSTRACT Objective: To characterize the profile of users at risk of developing diabetes mellitus type 2 according to sociodemographic and clinical variables. Method: Cross-sectional study, descriptive, quantitative approach conducted with 266 users of Basic Care. Inferential statistics analysis, calculating the crude prevalence ratio with confidence interval of 95% and Kruskal-Wallis test, and application of the multivariate technique simple Correspondence Analysis. Results: It was noted that 83.1% were women and 36.4% frequented the Family Health Unit from 1 to 5 years. Regarding the factors associated with diabetes mellitus type 2, 66.5% of the users were overweight and 77.9% were rated with central obesity. The great majority, 77.4%, did not practice physical activities and 21.1% had altered glycemia. Conclusion: The results showed that many risk factors for developing diabetes mellitus type 2 were among the population of the study.

RESUMEN Objetivo: Caracterizar el perfil de usuarios en riesgo de desarrollar diabetes mellitus tipo 2 de acuerdo con las variables sociodemográficas y clínicas. Método: Estudio transversal, descriptivo, de abordaje cuantitativo realizado con 266 usuarios de la Atención Básica. Análisis estadístico inferencial, con el cálculo de las razones de prevalencias brutas con intervalo de confianza del 95% y la prueba de Kruskal-Wallis, y la aplicación de la técnica multivariada Análisis de Correspondencia simple. Resultados: Se constató que el 83,1% eran mujeres y el 36,4% frecuentaban la Unidad de Salud de la Familia de 1 a 5 años. Sobre los factores asociados a la diabetes mellitus tipo 2, el 66,5% de los usuarios estaba con sobrepeso; el 77,9% fue clasificado con obesidad central; la gran mayoría, el 77,4% no practicaba actividad física y el 21,1% tenía la glucemia alterada. Conclusión: Los resultados mostraron que diversos factores de riesgo para el desarrollo de la diabetes mellitus tipo 2 estuvieron presentes en la población del estudio.

Abstract: INTRODUCTION: Due to its frequency and morbidity, such as that caused by scorpions have achieved public health importance in certain regions of the world. The present exploratory ecological study aimed to characterize the epidemiological profile and spatial distribution of scorpion stings in Campina Grande, State of Paraíba in Northeastern Brazil. METHODS: Geographical information system techniques were used to record the scorpion stings, and Google Earth software, Track Maker, and ArcGIS 10 Esri were used as geocoding databases. The Moran test was used to evaluate spatial correlation, and the Pearson chi-square test was used to analyze associations between scorpion stings and socioeconomic variables. RESULTS: The study evaluated 1,466 scorpion stings. Envenomations were more frequent among women (n = 908, 61.9%), and most patients were aged 13-28 years (n = 428, 29.2%). The Southern region of the city had the largest number of registered cases (n = 548, 37.4%), followed by the Western region (n = 510, 34.8%). CONCLUSIONS: Spatial analysis of scorpionism revealed an irregular occurrence in Campina Grande. Further, no association was observed between the socioeconomic factors analyzed and the geographic location of the scorpion envenomations. Detection of spatial areas with an increased risk of scorpionism can help prioritize adoption of preventive measures in these regions to reduce the associated incidence and morbidity.

Resumo Este estudo reporta a ocorrência de metacercárias de Austrodiplostomum compactum na espécie de peixe de água doce Schizodon intermedius (ximborê/piava), oriunda de um reservatório Neotropical no rio Paranapanema, Estado de São Paulo, Brasil. Um total de 75 peixes foram coletados, sendo que 38 estavam infectados com metacercárias de A. compactum (prevalência = 50,67%) nos olhos. A intensidade média de infecção e abundância média foram 9,05 ± 4,26 (1-155) e 4,59 ± 2,20 (0-155), respectivamente. O Índice de Discrepância de Poulin foi de 0,87, e quatro exemplares apresentaram mais do que 10 metacercárias em seus olhos. Não foram observadas correlação entre abundância média e comprimento padrão, peso total e fator de condição (p>0,05). Esse é o primeiro registro dessa espécie de metacercária para S. intermedius.

Abstract This study reports the occurrence of Austrodiplostomum compactum metacercariae in the freshwater fish Schizodon intermedius (ximborê/piava) from a Neotropical reservoir in the Paranapanema River, state of São Paulo, Brazil. From a total of 75 fish collected, we found 38 infected with A. compactum metacercariae (prevalence = 50.67%) in the eyes. The mean intensity of infection and mean abundance were 9.05 ± 4.26 (1-155) and 4.59 ± 2.20 (0-155), respectively. Poulin's Discrepancy Index was 0.87 and four specimens presented more than 10 metacercariae in their eyes. No correlation was observed between parasite abundance and standard length, total weight and condition factor (p>0.05). These metacercariae are reported for the first time in S. intermedius.

Resumo:OBJETIVO:verificar se o conhecimento da técnica de oferta da dieta pelo copo, o recebimento de treinamento e o tempo de trabalho influenciam a postura do técnico de enfermagem, a postura do recém-nascido e o posicionamento do copo.MÉTODOS:trata-se de um estudo observacional, descritivo, transversal, do qual participaram 15 profissionais, técnicos de enfermagem responsáveis pela administração da dieta às crianças, no momento do oferecimento do leite pelo copo, na ausência da genitora. Foi definido nível de significância estatística de 0,05.RESULTADOS:apenas nove indivíduos foram treinados (p=0,273) e 11 referiram não ter conhecimento da técnica (p=0,011). O oferecimento da dieta ocorreu em pé (p=0,001), com o derramamento do leite na boca da criança (p=0,010), sendo posicionada com as regiões occipital e cervical apoiadas (p-valor = 0,001). Não houve associação entre o conhecimento da técnica, recebimento de treinamento, tempo de trabalho às variáveis postura do técnico de enfermagem, postura do recém-nascido e posicionamento do copo.CONCLUSÃO:a postura de oferta da alimentação é realizada em pé, há derramamento da dieta na cavidade oral do bebê e não há influência das posturas do neonato, do técnico ou do copo por conta do conhecimento da técnica, realização de treinamento e tempo de trabalho.

Abstract:PURPOSE: to verify if knowing the technique of offering the diet in a cup, the training and the working time have influence on the nursing technician posture, the newborn posture and the cup position.METHODS: it was an observational, descriptive, transversal study, in which participated 15 professionals - nursing technicians responsible for diet administration in children, offering milk in a cup, during mother's absence. The statistical significance level was 0.05.RESULTS: only nine individuals were trained (p = 0.273) and 11 technicians declared had no knowledge about the technique (p = 0.011). The diet was offered with technicians standing (p = 0.001), pouring milk into child's mouth (p = 0.010) positioned with the occipital and cervical regions supported (p = 0.001). There was no association between technique knowledge, receiving training and working time to the different nursing technician's posture, newborn's posture and cup position.CONCLUSION: the posture of offering the diet is standing, milk is poured into babies' oral cavity and there is no influence in newborn, technician or cup position, caused by technical knowledge, training and working time.