A gravidez na adolescência é um problema significativo de saúde pública no Brasil, contribuindo para altas taxas de morbimortalidade entre mulheres jovens. Durante a gestação, muitas adolescentes abandonam a escola e o trabalho, o que resulta em menor qualificação e maior vulnerabilidade ao mercado de trabalho informal. Além disso, as adolescentes grávidas enfrentam riscos elevados de complicações gestacionais e desafios emocionais, como ansiedade e depressão. A pandemia exacerbou essas vulnerabilidades, especialmente em relação ao abuso doméstico, devido ao isolamento social. Este estudo justifica-se pela necessidade de compreender o perfil demográfico e as características das parturientes adolescentes no Ceará entre 2020 e 2022, oferecendo subsídios para políticas públicas que visem melhorar a qualidade de vida dessas jovens e de seus filhos. Todos os dados foram analisados utilizando R. Durante o período analisado, foram registrados 331.924 nascimentos vivos no Ceará, dos quais 21.667 (6,53%) eram de mães com idade igual ou inferior a 17 anos. A idade média das mães adolescentes foi de 15,93 ± 1,11 anos, enquanto a média para as mães adultas foi de 28,00 ± 6,21 anos, evidenciando uma diferença estatisticamente significativa (Teste-t de Student, P < 0,05). A análise também revelou uma diferença significativa entre a idade dos pais de crianças nascidas de mães adolescentes (22,25 ± 5,72 anos) em comparação à idade dos pais de crianças nascidas de mães adultas (32,45 ± 7,81 anos) (Figura 3, Teste-T, P < 0,05). No que se refere à etnia, adolescentes indígenas representaram 9,95% dos casos de gravidez, seguidas pelas adolescentes pardas (7,26%) e pretas (5,9%). A menor proporção foi observada entre adolescentes brancas (4,43%). Não houve diferença estatisticamente significativa entre os grupos indígenas, pardas, pretas e a população amarela. Quanto ao estado civil, 71% das adolescentes se declararam solteiras. A análise educacional demonstrou uma tendência significativa de gravidez entre adolescentes com Ensino Fundamental II incompleto, completo, ou Ensino Médio incompleto, indicando que essas jovens ainda estavam em fase de conclusão desses ciclos escolares. Não foi observada uma relação significativa entre a redução da idade materna e a diminuição do escore APGAR em recém-nascidos (APGAR = 0,014 × “IDADE DA MÃE” + 8,5; P < 0,05, R² = 0,0004). Além disso, não houve diferença significativa na proporção de anomalias congênitas entre os nascimentos de mães adolescentes e adultas.

El embarazo en la adolescencia es un problema significativo de salud pública en Brasil, que contribuye a altas tasas de morbimortalidad entre las mujeres jóvenes. Durante el embarazo, muchas adolescentes abandonan la escuela y el trabajo, lo que resulta en menor calificación y mayor vulnerabilidad en el mercado laboral informal. Además, las adolescentes embarazadas enfrentan mayores riesgos de complicaciones gestacionales y desafíos emocionales, como ansiedad y depresión. La pandemia exacerbó estas vulnerabilidades, especialmente en relación con el abuso doméstico, debido al aislamiento social. Este estudio se justifica por la necesidad de comprender el perfil demográfico y las características de las madres adolescentes en Ceará entre 2020 y 2022, ofreciendo apoyo para políticas públicas que busquen mejorar la calidad de vida de estas jóvenes y sus hijos. Todos los datos fueron analizados utilizando R. Durante el período analizado, se registraron 331.924 nacimientos vivos en Ceará, de los cuales 21.667 (6,53%) eran de madres de 17 años o menos. La edad promedio de las madres adolescentes fue de 15,93 ± 1,11 años, mientras que la media para las madres adultas fue de 28,00 ± 6,21 años, evidenciando una diferencia estadísticamente significativa (Prueba t de Student, P < 0,05). El análisis también reveló una diferencia significativa entre la edad de los padres de niños nacidos de madres adolescentes (22,25 ± 5,72 años) en comparación con la edad de los padres de niños nacidos de madres adultas (32,45 ± 7,81 años) (Prueba de Wilcoxon, P < 0,05). En cuanto a la etnia, las adolescentes indígenas representaron el 9,95% de los casos de embarazo, seguidas por las adolescentes mestizas (7,26%) y negras (5,9%). La menor proporción se observó entre las adolescentes blancas (4,43%). No hubo diferencia estadísticamente significativa entre los grupos indígenas, mestizas, negras y la población amarilla. En cuanto al estado civil, el 71% de las adolescentes se declararon solteras. El análisis educativo demostró una tendencia significativa de embarazo entre adolescentes con secundaria incompleta o completa, o educación media incompleta, lo que indica que estas jóvenes aún estaban en proceso de completar estos niveles educativos. No se observó una relación significativa entre la disminución de la edad materna y la reducción de la puntuación APGAR en los recién nacidos (APGAR = 0,014 × "EDAD DE LA MADRE" + 8,5; P < 0,05, R² = 0,0004). Además, no hubo diferencia significativa en la proporción de anomalías congénitas entre los nacimientos de madres adolescentes y adultas.

Adolescent pregnancy is a significant public health issue in Brazil, contributing to high morbidity and mortality rates among young women. During pregnancy, many adolescents drop out of school and work, leading to lower qualifications and increased vulnerability to the informal labor market. Moreover, pregnant adolescents face higher risks of gestational complications and emotional challenges, such as anxiety and depression. The pandemic exacerbated these vulnerabilities, particularly concerning domestic abuse, due to social isolation. This study is justified by the need to understand the demographic profile and characteristics of adolescent mothers in Ceará between 2020 and 2022, providing support for public policies aimed at improving the quality of life for these young women and their children. All data were analyzed using R. During the analyzed period, 331,924 live births were recorded in Ceará, of which 21,667 (6.53%) were from mothers aged 17 years or younger. The average age of adolescent mothers was 15.93 ± 1.11 years, while the average for adult mothers was 28.00 ± 6.21 years, showing a statistically significant difference (Student's t-test, P < 0.05). The analysis also revealed a significant difference between the age of fathers of children born to adolescent mothers (22.25 ± 5.72 years) compared to the age of fathers of children born to adult mothers (32.45 ± 7.81 years) (Wicoxon test, P < 0.05). Regarding ethnicity, indigenous adolescents accounted for 9.95% of pregnancy cases, followed by brown (7.26%) and black (5.9%) adolescents. The lowest proportion was observed among white adolescents (4.43%). There was no statistically significant difference among indigenous, mixed-race, black, and yellow populations. Concerning marital status, 71% of adolescents declared themselves single. Educational analysis showed a significant trend of pregnancy among adolescents with incomplete or complete middle school or incomplete high school education, indicating that these young women were still in the process of completing these educational levels. There was no significant relationship between decreasing maternal age and a reduction in newborns' APGAR scores (APGAR = 0.014 × "MOTHER'S AGE" + 8.5; P < 0.05, R² = 0.0004). Additionally, there was no significant difference in the proportion of congenital anomalies between births of adolescent and adult mothers.

Resumo Fundamento: O fondaparinux é um anticoagulante eficaz e seguro usado no tratamento de síndromes coronarianas agudas (SCAs). No entanto, devido à baixa representatividade de indivíduos obesos em ensaios clínicos, os efeitos de se aplicar os resultados desse medicamento nesta população continuam incertos. Objetivos: Comparar o fondaparinux à enoxaparina no tratamento de obesos com SCA. Métodos: Este é um estudo do tipo coorte retrospectivo, incluindo indivíduos obesos (IMC ≥ 30 Kg/m2) internados com Infarto do Miocárdio sem Elevação do Segmento ST (IAMSSST) ou Angina Instável (AI) e tratados com fondaparinux ou enoxaparina entre 2010 e 2020. Os grupos que receberam fondaparinux e enoxaparina foram comparados quanto suas características clínicas e laboratoriais usando o teste do qui-quadrado e o teste de Mann-Whitney, conforme apropriado. A incidência dos desfechos primários (morte, reinfarto, acidente vascular cerebral, sangramento maior) foi comparada entre os grupos. Um p<0,05 foi considerado estatisticamente significativo em todas as análises. Resultados: Um total de 367 pacientes obesos com IAMSSST ou AI foi incluído, dos quais 258 usaram fondaparinux e 109 usaram enoxaparina. A idade média foi 64 ± 12 anos, 52,9% eram do sexo masculino. A prevalência e diabetes, hipertensão, dislipidemia, doença arterial coronariana prévia, acidente vascular cerebral prévio, e implementação de estratégia invasiva foi similar entre os grupos. A incidência do desfecho primário foi 4,7% no grupo fondaparinux e 5,5% no grupo enoxaparina (p = 0,729). Não houve diferença entre os grupos quando os componentes do desfecho primário foram analisados separadamente. Conclusão: Em uma amostra de pacientes obesos com IAMSSST ou AI, não houve diferença na ocorrência do desfecho composto (morte, acidente vascular cerebral, reinfarto, sangramento maior) entre os pacientes que utilizaram fondaparinux ou enoxaparina. Fundamento SCAs. SCAs . (SCAs) entanto clínicos incertos Objetivos SCA Métodos retrospectivo IMC 3 Kg/m2 Kgm2 Kgm Kg m2 m (IAMSSST (AI 201 2020 quiquadrado qui quadrado MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney apropriado morte, morte (morte reinfarto maior p005 p 0 05 p<0,0 análises Resultados 36 incluído 25 10 6 1 anos 529 52 9 52,9 masculino diabetes hipertensão dislipidemia prévia prévio 47 4 7 4,7 55 5 5,5 0,729. 0729 0,729 729 0,729) separadamente Conclusão (SCAs Kg/m 20 202 p00 p<0, 2 52, 4, 5, 072 0,72 72 p0 p<0 07 0,7 p< 0,

Abstract Background: Fondaparinux is an effective and safe anticoagulant in the treatment of acute coronary syndromes (ACS). However, due to the low representation of obese individuals in clinical trials, the effects of applying the results of this drug to this population remain uncertain. Objectives: To compare Fondaparinux to Enoxaparin in the treatment of obese patients with ACS. Methods: This is a retrospective cohort study, including obese individuals (BMI ≥ 30 Kg/m2) admitted with non-ST-segment elevation myocardial infarction (NSTEMI) or unstable angina (UA) and treated with Fondaparinux or Enoxaparin between 2010 and 2020. The Fondaparinux and Enoxaparin groups were compared for their clinical and laboratory characteristics using chi-square and Mann-Whitney tests, as appropriate. The incidence of primary outcomes (death, reinfarction, stroke, major bleeding) was compared between groups. P-value < 0.05 was considered significant for all analyses. Results: A total of 367 obese patients with NSTEMI or UA were included, of whom 258 used Fondaparinux and 109 used Enoxaparin. Mean age was 64 ± 12 years, and 52.9% were male. The prevalence of diabetes, hypertension, dyslipidemia, prior coronary artery disease, prior stroke, and implementation of invasive strategy was similar between groups. The incidence of the primary outcome was 4.7% in the Fondaparinux group and 5.5% in the Enoxaparin group (p = 0.729). There was no difference between groups when analyzing the components of the primary outcome separately. Conclusion: In a sample of obese patients with NSTEMI or UA, there was no difference in the occurrence of the composite outcome (death, stroke, reinfarction, major bleeding) between patients who used Fondaparinux or Enoxaparin. Background ACS . (ACS) However trials uncertain Objectives Methods study BMI 3 Kg/m2 Kgm2 Kgm Kg m2 m nonSTsegment non ST segment (NSTEMI (UA 201 2020 chisquare chi square MannWhitney Mann Whitney tests appropriate death, death (death reinfarction stroke bleeding Pvalue P value 005 0 05 0.0 analyses Results 36 included 25 10 6 1 years 529 52 9 52.9 male diabetes hypertension dyslipidemia disease 47 4 7 4.7 55 5 5.5 p 0.729. 0729 0.729 729 0.729) separately Conclusion (ACS Kg/m 20 202 00 0. 2 52. 4. 5. 072 0.72 72 07 0.7

ABSTRACT Objective: To analyze the spatiotemporal epidemiological dynamics of meningitis in Brazil, between 2010 and 2019. Methods: Descriptive ecological study with cases and deaths due to meningitis in Brazil (2010-2019) in the National Notifiable Diseases Information System (Sistema de Informações de Agravos de Notificação – SINAN). The following analyses were performed: (I) frequency analyses of cases and deaths, prevalence rates, mortality, lethality, Fisher's exact test, and chi-square test; (II) Prais-Winstein regression; and (III) Global, Local Moran's index, and Kernel density. Results: 182,126 cases of meningitis were reported in Brazil, of which 16,866 (9.26%) resulted in death, with prevalence rates of 9.03/100,000 inhabitants, mortality of 0.84/100,000 inhabitants, and lethality of 9.26%. There was a noted trend of decreasing prevalence rates (−9.5%, 95% confidence interval — 95%CI −13.92; −4.96, p<0.01) and mortality (−11.74%, 95%CI −13.92; −9.48, p<0.01), while lethality remained stable (−2.08%, 95%CI −4.9; 0.8; p<0.1941). The majority of cases were viral meningitis (45.7%), among 1-9 years old (32.2%), while the highest proportion of deaths was due to bacterial meningitis (68%), among 40-59 years old (26.3%). In the Moran and Kernel maps of prevalence and mortality rates, municipalities in the South, Southeast, and the capital of Pernambuco in the Northeast stood out with high rates; as for lethality, the North, Northeast, and Southeast coastal areas were highlighted. Conclusion: A decrease in meningitis cases and deaths was found in this study; however, the lethality rate was higher in areas with lower prevalence, emphasizing the need to enhance actions for identifying, monitoring, and providing health care for cases, as well as expanding vaccination coverage.

RESUMO Objetivo: Analisar a dinâmica epidemiológica espaçotemporal das meningites no Brasil, entre os anos de 2010 e 2019. Métodos: Estudo ecológico descritivo com os casos e óbitos por meningites no Brasil (2010–2019) no Sistema de Informações de Agravos de Notificação. Realizaram-se (I) análises de frequências dos casos e óbitos, taxas de prevalência, mortalidade, letalidade, testes de exato de Fisher e qui-quadrado; (II) regressão de Prais-Winsten; e (III) índice de Moran global, local e densidade de Kernel. Resultados: Notificaram-se 182.126 casos de meningites no Brasil, dos quais 16.866 (9,26%) evoluíram para óbito, com taxas de prevalência de 9,03/100.000/habitantes, mortalidade de 0,84/100.000/habitantes e letalidade de 9,26%. Destaca-se a tendência de decrescimento das taxas de prevalência (−9,5%, intervalo de confiança de 95% — IC95% −13,92; −4,96, p<0,01) e mortalidade (−11,74%, IC95% −13,92; −9,48, p<01,01), enquanto a letalidade se manteve estacionária (−2,08%, IC95% −4,9; 0,8; p<0,1941). A maioria dos casos foi de meningites virais (45,7%), entre 1 e 9 anos (32,2%), enquanto a maior parcela dos óbitos foi por meningites bacterianas (68%), entre 40 e 59 anos (26,3%). Nos mapas de Moran e Kernel das taxas de prevalência e mortalidade, destacaram-se com altas taxas os municípios do sul, sudeste e a capital de Pernambuco, no nordeste; já na letalidade, evidenciaram-se o norte, o nordeste e o litoral do sudeste. Conclusão: Encontrou-se decréscimo dos casos e óbitos por meningites neste estudo, entretanto a taxa de letalidade foi maior em áreas com menor prevalência, reforçando a necessidade do aprimoramento das ações de identificação, vigilância e assistência em saúde dos casos, bem como da ampliação da cobertura vacinal.

ABSTRACT The COVID-19-19 pandemic's global impact has accelerated the need for effective vaccines, challenging traditional, time-consuming, and costly vaccinology methods. Immunoinformatics emerges as a promising alternative to expedite vaccine development, thus this study aims to provide a comprehensive bibliometric analysis of its application in formulating SARS-CoV-2 vaccine prototypes. Employing VOSviewer software and data from the Web of Science database, this study conducted a bibliometric analysis. Key metrics included the global distribution of scientific publications, the most productive countries and institutions, influential authors, co-citation and co-authorship networks, and prevalent keywords in immunoinformatics research related to SARS-CoV-2 vaccines. The analysis encompassed 138 scholarly articles, with India emerging as a pivotal contributor, particularly through notable contributions from Adamas and Fakir Mohan universities. The most cited article, authored by Bhattacharya, received 226 citations, while Doytchinova was a prominent cited source, referenced in 96 of the 138 analyzed documents. The study observed substantial collaborative efforts among authors from 45 nations, with 85% of the research concentrated in just six countries. Pakistan demonstrated the highest level of international collaboration, contributing to 15/20 collaborative publications. Keywords such as 'SARS-CoV-2', 'immunoinformatics', and 'prediction' were frequently encountered across most of these documents. This bibliometric analysis elucidates the primary research trends in the field and delineates the global scope and distribution of immunoinformatics studies in the realm of SARS-CoV-2 vaccine development. These findings offer a vital overview of the current landscape, guiding future research directions and potential collaborative efforts in the pursuit of effective COVID-19 vaccines.

RESUMEN El impacto global de la pandemia de COVID-19 ha acelerado la necesidad de vacunas efectivas, lo que ha desafiado los métodos tradicionales de vacunología que son costosos y consumen mucho tiempo. La inmunoinformática surge como una alternativa prometedora para acelerar el desarrollo de vacunas. Este estudio tuvo como objetivo proporcionar un análisis bibliométrico exhaustivo de su aplicación en la formulación de prototipos de vacunas contra el SARS-CoV-2. Utilizando el software VOSviewer y datos de la base de datos Web of Science, se realizó un análisis bibliométrico. Las métricas clave incluyeron: la distribución global de publicaciones científicas, los países e instituciones más productivos, autores influyentes, redes de cocitación y coautoría y palabras clave prevalentes en la investigación de inmunoinformática relacionada con las vacunas contra el SARS-CoV-2. El análisis abarcó 138 artículos académicos; la India emergió como un contribuyente principal, particularmente a través de contribuciones notables de las universidades Adamas y Fakir Mohan. El artículo más citado fue el de Bhattacharya, que recibió 226 citas; mientras que Doytchinova fue una fuente citada prominente, referenciada en 96 de los 138 documentos analizados. El estudio observó esfuerzos colaborativos sustanciales entre autores de 45 naciones con el 85 % de la investigación concentrada en seis países. Pakistán demostró el nivel más alto de colaboración internacional, al contribuir con 15 de los 20 artículos colaborativos. Palabras clave como 'SARS-CoV-2', 'immunoinformatics' y 'prediction' se encontraron frecuentemente en la mayoría de estos documentos. Este análisis bibliométrico aclara las principales tendencias de investigación en el campo y delinea el alcance global y la distribución de los estudios de inmunoinformática en el ámbito del desarrollo de vacunas contra el SARS-CoV-2. Los hallazgos ofrecen una visión vital del panorama actual, guían investigaciones futuras y posibles esfuerzos colaborativos en la búsqueda de vacunas efectivas contra la COVID-19.

ABSTRACT Mineral flotation is a wet concentration operation that has a differentiating effect dependent on the surface properties of the minerals. Water quality is integral to the phosphate ore flotation, since the presence of certain ions in the solution can compromise the effectiveness of the operation. The objective of this study was to compare the effectiveness of phosphate ore flotation (dispersed air) before and after effluent treatment using coagulation, flocculation and dissolved air flotation (DAF) techniques. The mineral flotation tests were performed for new water (NW) and three effluents tailing dams (TD), simulated effluent with high concentrations of calcium and magnesium ions (SE) and simulated effluent after DAF treatment (SEDAF). The simulated effluent underwent two stages of aggregation followed by DAF for cation removal. The results showed that the proposed technique removed 91.6% of magnesium and 66.4% of calcium from the original simulated effluent (SE). The SEDAF presented better average values of mass recovery, content, and recovery of P2O5, confirming the effectiveness of the removing ions suggested as deleterious for mineral flotation. The flotation performance of the DAF-treated effluent was comparable to that of new water. This study underscores the significance of water quality management in optimizing mineral flotation processes. minerals dispersed coagulation (DAF techniques NW (NW TD, TD , (TD) SE (SE SEDAF. . (SEDAF) removal 916 91 6 91.6 664 66 4 66.4 SE. content P2O5 PO P O DAFtreated treated processes (TD (SEDAF 9 91. 66. P2O

Resumo O Brasil tem se firmado como o maior produtor mundial de sementes de urucum (Bixa orellana L.). Felizmente, o aumento da produção nacional tem sido acompanhado por uma melhoria da qualidade dessa matéria-prima. O urucum é uma cultura típica de pequenos produtores, que em geral usa seu conhecimento empírico para avaliar a qualidade do material que está produzindo. A observação visual da cor das sementes de urucum tem sido considerada padrão de qualidade por muitos produtores. Para avaliar as evidências científicas, o presente estudo avaliou amostras de sementes de urucum de 51 acessos do banco de germoplasma do Instituto Agronômico de Campinas (IAC), para determinar se existe correlação entre as concentrações de pigmentos com a cor das sementes e a influência da umidade nessa correlação. Foram avaliadas também as correlações entre as concentrações de pigmentos, umidade, lipídios e a cor (L*, a*, b*). Para a avaliação da cor, utilizamos um colorímetro com a medida da cor pelo sistema CIE L*, a*, b*. Apenas a correlação simples entre as variáveis Umidade e Lipídios foi considerada forte, pela classificação usada neste estudo. Quando se remove o efeito da Umidade (correlação parcial), apenas as variáveis bixina e a* apresentaram correlação significativa, considerada fraca pela classificação utilizada. Portanto, mesmo considerada fraca, há uma correspondência entre a cor vermelha das sementes de urucum com a concentração de bixina das amostras estudadas. Contudo, a diferença da cor (ΔEab) entre as amostras com maior e menor teor de bixina foi de apenas 1,44. Essa diferença indica que grandes variações nas concentrações de bixina nas sementes de urucum podem levar a pequenas variações de cor, dificultando o uso desse critério para o controle de qualidade desses grãos. Bixa L.. L L. . L.) Felizmente matériaprima. matériaprima matéria prima. prima matéria-prima produtores produzindo científicas 5 IAC, IAC , (IAC) (L* b b* b*) L* forte parcial, parcial parcial) significativa utilizada Portanto estudadas Contudo ΔEab (ΔEab 144 1 44 1,44 grãos (IAC (L 14 4 1,4 1,

Abstract Brazil has emerged as the world's largest producer of annatto seeds (Bixa orellana L.). Fortunately, the increase in national production has been accompanied by an improvement in the quality of this raw material. Annatto is a typical crop of small producers who usually use their empirical knowledge to evaluate the quality of the crop. Thefore, the visual observation of the color of annatto seeds has been considered a quality standard by many producers. To evaluate the scientific evidence, the present study evaluated annatto seeds from 51 accessions of the germplasm bank of the Agronomic Institute (Instituto Agronômico de Campinas - IAC) to determine a possible correlation between the pigment’s contents and the color of annatto seeds as well as the influence of humidity on this correlation. The correlations between the concentrations of pigments, humidity, lipids, and color (L*, a*, b*) were also evaluated. The color was evaluated using a colorimeter with measurements of the CIE L*, a*, b* scale. Only the correlation between the variables moisture and lipids was considered strong through the simple correlation, while the variables bixin content and coordinate a* presented a significant correlation while eliminating the effect of moisture (partial correlation). Thus, a correlation between the red color and the bixin concentration of annatto seeds was observed even though it was a weak correlation. In turn, the color difference (ΔEab) between the samples with higher and lower bixin contents was only 1.44. This difference indicates that large variations in the bixin concentrations may lead to small color changes in the annatto seeds, impairing the use of this criterion for quality control of these seeds. worlds world s Bixa L.. L L. . L.) Fortunately material Thefore evidence 5 Instituto IAC pigments pigment (L* b L* scale partial correlation) Thus turn ΔEab (ΔEab 144 1 44 1.44 (L 14 4 1.4 1.

RESUMO Objetivo: Analisar a dinâmica epidemiológica espaçotemporal das meningites no Brasil, entre os anos de 2010 e 2019. Métodos: Estudo ecológico descritivo com os casos e óbitos por meningites no Brasil (2010–2019) no Sistema de Informações de Agravos de Notificação. Realizaram-se (I) análises de frequências dos casos e óbitos, taxas de prevalência, mortalidade, letalidade, testes de exato de Fisher e qui-quadrado; (II) regressão de Prais-Winsten; e (III) índice de Moran global, local e densidade de Kernel. Resultados: Notificaram-se 182.126 casos de meningites no Brasil, dos quais 16.866 (9,26%) evoluíram para óbito, com taxas de prevalência de 9,03/100.000/habitantes, mortalidade de 0,84/100.000/habitantes e letalidade de 9,26%. Destaca-se a tendência de decrescimento das taxas de prevalência (−9,5%, intervalo de confiança de 95% — IC95% −13,92; −4,96, p<0,01) e mortalidade (−11,74%, IC95% −13,92; −9,48, p<01,01), enquanto a letalidade se manteve estacionária (−2,08%, IC95% −4,9; 0,8; p<0,1941). A maioria dos casos foi de meningites virais (45,7%), entre 1 e 9 anos (32,2%), enquanto a maior parcela dos óbitos foi por meningites bacterianas (68%), entre 40 e 59 anos (26,3%). Nos mapas de Moran e Kernel das taxas de prevalência e mortalidade, destacaram-se com altas taxas os municípios do sul, sudeste e a capital de Pernambuco, no nordeste; já na letalidade, evidenciaram-se o norte, o nordeste e o litoral do sudeste. Conclusão: Encontrou-se decréscimo dos casos e óbitos por meningites neste estudo, entretanto a taxa de letalidade foi maior em áreas com menor prevalência, reforçando a necessidade do aprimoramento das ações de identificação, vigilância e assistência em saúde dos casos, bem como da ampliação da cobertura vacinal. Objetivo 201 2019 Métodos 2010–2019 20102019 (2010–2019 Notificação Realizaramse Realizaram I (I quiquadrado qui quadrado qui-quadrado II (II PraisWinsten Prais Winsten Prais-Winsten III (III global Resultados Notificaramse Notificaram 182126 182 126 182.12 16866 16 866 16.86 9,26% 926 26 (9,26% óbito 903100000habitantes habitantes 03 100 000 9,03/100.000/habitantes 084100000habitantes 0 84 Destacase Destaca −9,5%, 95 5 (−9,5% IC95 IC −13,92 1392 13 92 496 4 96 −4,96 p<0,01 p001 p 01 −11,74%, 1174 11 74 (−11,74% 948 48 −9,48 p<01,01, p0101 p<01,01 , p<01,01) −2,08%, 208 2 08 (−2,08% −4,9 49 0,8 8 p<0,1941. p01941 p<0,1941 . 1941 p<0,1941) 45,7%, 457 45,7% 45 7 (45,7%) 32,2%, 322 32,2% 32 (32,2%) 68%, 68 68% (68%) 26,3%. 263 26,3% 3 (26,3%) destacaramse destacaram sul Pernambuco evidenciaramse evidenciaram norte Conclusão Encontrouse Encontrou estudo identificação vacinal 20 2010–201 2010201 (2010–201 18212 18 12 182.1 1686 86 16.8 9,26 (9,26 10 00 −9,5% (−9,5 IC9 −13,9 139 p<0,0 p00 −11,74% 117 (−11,74 94 −9,4 p010 p<01,0 −2,08% (−2,08 −4, 0, p0194 p<0,194 194 45,7 (45,7% 32,2 (32,2% 6 (68% 26,3 (26,3% 2010–20 201020 (2010–20 1821 182. 168 16. 9,2 (9,2 −9,5 (−9, −13, p<0, p0 −11,74 (−11,7 −9, p01 p<01, −2,08 (−2,0 −4 p019 p<0,19 19 45, (45,7 32, (32,2 (68 26, (26,3 2010–2 20102 (2010–2 9, (9, (−9 −13 p<0 −11,7 (−11, −9 p<01 −2,0 (−2, − p<0,1 (45, (32, (6 (26, 2010– (2010– (9 (− −1 p< −11, (−11 −2, (−2 (45 (32 ( (26 (2010 −11 (−1 −2 (4 (3 (2 (201 (20

ABSTRACT Objective: To analyze the spatiotemporal epidemiological dynamics of meningitis in Brazil, between 2010 and 2019. Methods: Descriptive ecological study with cases and deaths due to meningitis in Brazil (2010-2019) in the National Notifiable Diseases Information System (Sistema de Informações de Agravos de Notificação – SINAN). The following analyses were performed: (I) frequency analyses of cases and deaths, prevalence rates, mortality, lethality, Fisher's exact test, and chi-square test; (II) Prais-Winstein regression; and (III) Global, Local Moran's index, and Kernel density. Results: 182,126 cases of meningitis were reported in Brazil, of which 16,866 (9.26%) resulted in death, with prevalence rates of 9.03/100,000 inhabitants, mortality of 0.84/100,000 inhabitants, and lethality of 9.26%. There was a noted trend of decreasing prevalence rates (−9.5%, 95% confidence interval — 95%CI −13.92; −4.96, p<0.01) and mortality (−11.74%, 95%CI −13.92; −9.48, p<0.01), while lethality remained stable (−2.08%, 95%CI −4.9; 0.8; p<0.1941). The majority of cases were viral meningitis (45.7%), among 1-9 years old (32.2%), while the highest proportion of deaths was due to bacterial meningitis (68%), among 40-59 years old (26.3%). In the Moran and Kernel maps of prevalence and mortality rates, municipalities in the South, Southeast, and the capital of Pernambuco in the Northeast stood out with high rates; as for lethality, the North, Northeast, and Southeast coastal areas were highlighted. Conclusion: A decrease in meningitis cases and deaths was found in this study; however, the lethality rate was higher in areas with lower prevalence, emphasizing the need to enhance actions for identifying, monitoring, and providing health care for cases, as well as expanding vaccination coverage. Objective 201 2019 Methods 20102019 (2010-2019 Sistema SINAN. SINAN . SINAN) performed I (I Fishers Fisher s test chisquare chi square II (II PraisWinstein Prais Winstein regression III (III Global Morans index density Results 182126 182 126 182,12 16866 16 866 16,86 9.26% 926 9 26 (9.26% death 903100000 03 100 000 9.03/100,00 inhabitants 084100000 0 84 0.84/100,00 −9.5%, 95 5 (−9.5% 95CI CI −13.92 1392 13 92 496 4 96 −4.96 p<0.01 p001 p 01 −11.74%, 1174 11 74 (−11.74% 948 48 −9.48 p<0.01, , −2.08%, 208 2 08 (−2.08% −4.9 49 0.8 8 p<0.1941. p01941 p<0.1941 1941 p<0.1941) 45.7%, 457 45.7% 45 7 (45.7%) 19 1 1- 32.2%, 322 32.2% 32 (32.2%) 68%, 68 68% (68%) 4059 40 59 40-5 26.3%. 263 26.3% 3 (26.3%) South North highlighted Conclusion however identifying monitoring coverage 20 2010201 (2010-201 18212 18 12 182,1 1686 86 16,8 9.26 (9.26 90310000 10 00 9.03/100,0 08410000 0.84/100,0 −9.5% (−9.5 −13.9 139 p<0.0 p00 −11.74% 117 (−11.74 94 −9.4 −2.08% (−2.08 −4. 0. p0194 p<0.194 194 45.7 (45.7% 32.2 (32.2% 6 (68% 405 40- 26.3 (26.3% 201020 (2010-20 1821 182, 168 16, 9.2 (9.2 9031000 9.03/100, 0841000 0.84/100, −9.5 (−9. −13. p<0. p0 −11.74 (−11.7 −9. −2.08 (−2.0 −4 p019 p<0.19 45. (45.7 32. (32.2 (68 26. (26.3 20102 (2010-2 9. (9. 903100 9.03/100 084100 0.84/100 (−9 −13 p<0 −11.7 (−11. −9 −2.0 (−2. − p01 p<0.1 (45. (32. (6 (26. (2010- (9 90310 9.03/10 08410 0.84/10 (− −1 p< −11. (−11 −2. (−2 (45 (32 ( (26 (2010 9031 9.03/1 0841 0.84/1 −11 (−1 −2 (4 (3 (2 (201 903 9.03/ 084 0.84/ (20 90 9.03 0.84 9.0

Abstract In many cases, traditional analysis of breeding trials based on analysis of variance (ANOVA) do not allow a suitable genetic evaluation. Alternatively, mixed model-based approaches create the possibility of dealing with unbalanced data and modeling spatial trends. The aims of this study were to compare the goodness-of-fit of the model and the genotype ranking through different residual modeling approaches and to select the best performing tropical wheat genotypes based on the best-fitting model. A panel of tropical wheat genotypes was evaluated in three field trials conducted between 2020 and 2021 for grain yield. Linear mixed model analyses were used on the data to estimate the genetic parameters and to predict the genotypic values in analyses of single- and multi-environment trials. Accounting for spatial trends in the analyses of single- and multi-environment trials provides better outcomes than the compound symmetry model does. cases ANOVA (ANOVA evaluation Alternatively modelbased goodnessoffit goodness fit bestfitting fitting 202 yield single multienvironment multi environment does 20 2

ABSTRACT The Verbal Autopsy (VA) is a questionnaire about the circumstances surrounding a death. It was widely used in Brazil to assist in postmortem diagnoses and investigate excess mortality during the Coronavirus Disease 2019 (COVID-19) pandemic. This study aimed to determine the accuracy of investigating acute respiratory distress syndrome (ARDS) using VA. This is a cross-sectional study with prospective data collected from January 2020 to August 2021 at the Death Verification Service of Sao Luis city, Brazil. VA was performed for suspected COVID-19 deaths, and one day of the week was randomly chosen to collect samples from patients without suspected COVID-19. Two swabs were collected after death and subjected to reverse transcription-polymerase chain reaction (RT-PCR) for SARS-CoV-2 detection. Of the 250 cases included, the VA questionnaire identified COVID-19-related ARDS in 67.2% (52.98% were positive for COVID-19). The sensitivity of the VA questionnaire was 0.53 (0.45–0.61), the specificity was 0.75 (0.64–0.84), the positive predictive value was 0.81 (0.72–0.88), and the negative predictive value was 0.44 (0.36–0.53). The VA had a lower-than-expected accuracy for detecting COVID-19 deaths; however, because it is an easily accessible and cost-effective tool, it can be combined with more accurate methods to improve its performance. (VA 201 COVID19 COVID 19 (COVID-19 pandemic (ARDS crosssectional cross sectional 202 city COVID-1 deaths COVID19. 19. transcriptionpolymerase transcription polymerase RTPCR RT PCR (RT-PCR SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- detection 25 included COVID19related COVIDrelated related 672 67 67.2 52.98% 5298 52 98 (52.98 . COVID-19) 053 0 53 0.5 0.45–0.61, 045061 0.45–0.61 , 45 61 (0.45–0.61) 075 75 0.7 0.64–0.84, 064084 0.64–0.84 64 84 (0.64–0.84) 081 81 0.8 0.72–0.88, 072088 0.72–0.88 72 88 (0.72–0.88) 044 44 0.4 0.36–0.53. 036053 0.36–0.53 36 (0.36–0.53) lowerthanexpected lower than expected however costeffective cost effective tool performance 20 COVID1 1 (COVID-1 COVID- SARS-CoV 6 67. 52.98 529 5 9 (52.9 05 0. 04506 0.45–0.6 4 (0.45–0.61 07 7 06408 0.64–0.8 8 (0.64–0.84 08 07208 0.72–0.8 (0.72–0.88 04 03605 0.36–0.5 3 (0.36–0.53 (COVID- 52.9 (52. 0450 0.45–0. (0.45–0.6 0640 0.64–0. (0.64–0.8 0720 0.72–0. (0.72–0.8 0360 0.36–0. (0.36–0.5 (COVID 52. (52 045 0.45–0 (0.45–0. 064 0.64–0 (0.64–0. 072 0.72–0 (0.72–0. 036 0.36–0 (0.36–0. (5 0.45– (0.45–0 06 0.64– (0.64–0 0.72– (0.72–0 03 0.36– (0.36–0 ( 0.45 (0.45– 0.64 (0.64– 0.72 (0.72– 0.36 (0.36– (0.45 0.6 (0.64 (0.72 0.3 (0.36 (0.4 (0.6 (0.7 (0.3 (0. (0

ABSTRACT BACKGROUND: Acute kidney failure is a serious consequence of coronavirus disease 2019 (COVID-19). OBJECTIVES: To identify the prevalence of COVID-19, kidney failure, frequency of death, and associated factors in patients receiving intensive care. DESIGN AND SETTING: Analytical cross-sectional study conducted in the intensive care unit (ICU) of a medium-sized philanthropic general hospital in center-west Minas Gerais. METHODS: Adults and older individuals who underwent real-time polymerase chain reaction testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were evaluated by the nephrology team. RESULTS: Among the 176 patients, the prevalence of COVID-19 and acute kidney injury (AKI) were 103 (58.5%) and 132 (75%), respectively, and 44 (25%) had chronic kidney disease (CKD) and 16 (15,5%) were positive for SARS-CoV-2. In the Charlson index classification, which estimates the risk of death, a statistically significant difference was identified in the percentages of groups with and without COVID-19 for indices 0, 1, and 2. There was a significant association between kidney disease and ICU mortality (P < 0.05). Patients with CKD had fewer fatal outcomes (13/97, 13.4%) than those with AKI (85/97, 87.6%). CONCLUSIONS: COVID-19 rates remained high long after diagnosis and prevention of SARS-CoV-2 infection. In addition, a higher death rate among patients who developed AKI, whose prevalence was also greater than that in the national literature, regardless of the presence of COVID-19, revealed a worrying scenario and corroborated the need for early and judicious approaches to preserve the lives of patients with AKI admitted to intensive care units. BACKGROUND 201 COVID19. COVID19 COVID 19 . (COVID-19) OBJECTIVES COVID19, 19, SETTING crosssectional cross sectional (ICU mediumsized medium sized centerwest center west Gerais METHODS realtime real time SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 team RESULTS 17 COVID-1 (AKI 10 58.5% 585 58 5 (58.5% 13 75%, 75 75% , (75%) respectively 4 25% 25 (25% (CKD 1 15,5% 155 15 (15,5% SARSCoV2. classification 0 P 0.05. 005 0.05 05 0.05) 13/97, 1397 97 (13/97 13.4% 134 85/97, 8597 85 (85/97 87.6%. 876 87.6% 87 6 87.6%) CONCLUSIONS SARS-CoV- infection addition literature units 20 COVID1 (COVID-19 (SARS-CoV- COVID- 58.5 (58.5 7 (75% (25 15,5 (15,5 00 0.0 13/97 139 9 (13/9 13.4 85/97 859 8 (85/9 87.6 SARS-CoV (COVID-1 (SARS-CoV 58. (58. (75 (2 15, (15, 0. 13/9 (13/ 13. 85/9 (85/ 87. (COVID- (58 (7 ( (15 13/ (13 85/ (85 (COVID (5 (1 (8

Resumo Objetiva-se identificar as práticas inovadoras desenvolvidas pelos professores de Educação Física e as barreiras que impulsionam o desinvestimento pedagógico. Uma pesquisa-ação encampou uma formação continuada em Manaus/AM, cujos participantes foram discentes e professores. Diários de campo, produções textuais e relatos de avaliação compuseram o material empírico alvo de uma análise de conteúdo. As práticas inovadoras se materializaram na inclusão de conteúdos e em aulas inclusivas e críticas. A cultura escolar, a desvalorização da disciplina e a falta de tempo para o planejamento foram obstáculos. Advoga-se por políticas de formação que foquem no desenvolvimento profissional e considerem os professores como pesquisadores de sua prática. Objetivase Objetiva pedagógico pesquisaação pesquisa ação ManausAM Manaus AM Manaus/AM campo conteúdo críticas escolar obstáculos Advogase Advoga prática

Abstract We aimed to identify the innovative practices developed by physical education teachers and the barriers that produce pedagogical disinvestment. An action-research encompassing a continuing education program in Manaus/AM whose participants were students and teachers. Field diaries, textual productions, and evaluation reports composed the empirical material analyzed. The innovative practices materialized in the inclusion of subjects and inclusive and critical classes. Some barriers were the school culture, the devaluation of the subject, and the lack of time for planning. We advocate for training policies that focus on professional development and consider teachers as researchers of their practice. disinvestment actionresearch action research ManausAM Manaus AM diaries productions analyzed classes culture subject planning practice

Resumen Planteamos identificar las prácticas innovadoras desarrolladas por los profesores de Educación Física y las barreras que producen la desinversión pedagógica. Una investigación-acción abarcó una educación continuada en Manaos/AM cuyos participantes fueron alumnos y profesores. Diarios de campo, producciones textuales y reportes de evaluación compusieron el material empírico objeto de un análisis de contenido. Las prácticas innovadoras se materializaron en la inclusión de contenidos y en clases inclusivas y críticas. La cultura escolar, la desvalorización de la disciplina y la falta de tiempo para la planificación fueron barreras. Abogamos por políticas de formación centradas en el desarrollo profesional y que consideren a los profesores como investigadores de su práctica. pedagógica investigaciónacción investigación acción ManaosAM Manaos AM campo contenido críticas escolar práctica

Resumo O aquecimento global é atribuído ao aumento das emissões de gases de efeito estufa (GEE), como dióxido de carbono (CO2), metano (CH4) e óxido nitroso (N2O). As mudanças no uso da terra têm impactos significativos nas emissões de GEE, sendo responsáveis por aproximadamente 44% das emissões do país em 2019. Essa é uma revisão que aborda as principais rotas de formação dos GEE no solo com foco na influência das mudanças do uso da terra nas emissões de GEE. Constata-se que as emissões de CO2 pelo solo estão relacionadas à respiração de raízes, microrganismos e decomposição da matéria orgânica (MO) do solo, assim mudanças no uso da terra podem alterar as características do solo, favorecendo a intensificação das emissões de CO2. As emissões de CH4 pelo solo ocorrem em condições de anaerobiose por microrganismos metanogênicos, no entanto as mudanças no uso da terra, como a conversão de florestas em pastagens, podem aumentar as emissões de CH4 devido a uma maior concentração de microrganismos metanogênicos no solo. Já o N2O é produzido no solo durante o processo de nitrificação e desnitrificação por microrganismos, e a fertilização nitrogenada em áreas agrícolas pode aumentar as emissões de N2O, especialmente quando associada à umidade e disponibilidade de carbono orgânico no solo. Destaca-se a importância de compreender as dinâmicas de formação e emissão de GEE decorrentes das mudanças de uso da terra, pois estratégias eficientes de manejo podem reduzir essas emissões e contribuir para o cumprimento das metas do Brasil em relação à redução de GEE estabelecidas em acordos internacionais. , (GEE) CO2, CO (CO2) CH (CH4 N2O. NO . N (N2O) 44 2019 Constatase Constata se raízes MO (MO pastagens Destacase Destaca internacionais (GEE (CO2 (CH (N2O 4 201 (CO 20 2

Abstract Global warming is attributed to the increase in greenhouse gas (GHG) emissions, such as carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O). Land use changes significantly impact on GHG emissions, accounting for approximately 44% of the country’s emissions in 2019. This review addresses the main pathways of GHG formation in the soil, focusing on the influence of land use changes on GHG emissions. It is found that soil CO2 emissions are related to root respiration, microorganisms, and organic matter (OM) decomposition in the soil. Changes in land use can alter soil characteristics, favoring increased CO2 emissions. Soil CH4 emissions occur under anaerobic conditions by methanogenic microorganisms; however, land use changes, such as forest conversion to pasture, can increase CH4 emissions due to a higher concentration of methanogenic microorganisms in the soil. On the other hand, N2O is produced in the soil during nitrification and denitrification processes by microorganisms, and nitrogen fertilization in agricultural areas can increase N2O emissions, especially when associated with soil moisture and the availability of organic carbon. It is important to understand the dynamics of GHG formation and emissions resulting from land use changes because efficient management strategies can reduce these emissions and contribute to Brazil’s goals for GHG reduction as established in international agreements. (GHG CO2, CO , (CO2) CH4, CH (CH4) N2O. NO . N O (N2O) 44 countrys country s 2019 respiration OM (OM characteristics however pasture hand Brazils Brazil agreements (CO2 (CH4 (N2O 4 201 (CO (CH 20 2

Resumo Objetivo Analisar o impacto pandemia de COVID-19 sobre a residência de ginecologia e obstetrícia do Estado de São Paulo. Métodos Estudo transversal desenvolvido por representantes dos residentes da Associação de Ginecologia e Obstetrícia do Estado de São Paulo (SOGESP). Foram coletados dados de questionários aplicados aos residentes de ginecologia e obstetrícia cadastrados no site da SOGESP em fevereiro de 2022. Os entrevistados responderam sobre repercussões da pandemia sobre a residência médica e se tiveram suporte técnico e psicológico durante o período. Resultados Foram levantados 247 questionários de residentes de ginecologia e obstetrícia. Os residentes apresentaram idade de 28,3 ± 3 anos, sendo a maioria do sexo feminino (88,4%). O deslocamento para “covidários” foi referido por 62,34% dos avaliados, porém somente 35,6% referiram equipamento de proteção individual completamente adequado e apenas 7,7% referiram instrução completa teórica e técnica para o suporte destes pacientes. Quase a totalidade dos entrevistados afirmou que o setor de ginecologia foi o mais afetado. A maioria dos entrevistados considerou que o os residentes do segundo ano foram os que tiveram maior prejuízo, sendo que mais da metade dos residentes do 1° e 2° ano afirmou ter desejado desistir da residência durante a pandemia. Mais de 80% dos residentes referiram aulas teóricas e/ou apresentação de artigos online, reforçando o fato de que as atividades virtuais ganharam um espaço maior dentro da residência médica. Conclusão A pandemia impactou nas residências em maior proporção nos ambulatórios e cirurgias ginecológicas, interferindo também sobre o desejo do médico de seguir com o programa. COVID19 COVID 19 COVID-1 SOGESP. . (SOGESP) 2022 período 24 283 28 28, anos 88,4%. 884 88,4% 88 4 (88,4%) covidários “covidários 6234 62 34 62,34 avaliados 356 35 6 35,6 77 7 7,7 pacientes afetado prejuízo 1 2 80 eou ou online ginecológicas programa COVID1 COVID- (SOGESP 202 88,4 8 (88,4% 623 62,3 35, 7, 20 88, (88,4 62, (88, (88 (8 (

Abstract Objective To analyze the impact of the COVID-19 pandemic on the residency of gynecology and obstetrics in São Paulo. Methods Cross-sectional study developed by representatives of residents of the Association of Gynecology and Obstetrics of the State of São Paulo (SOGESP, in the Portuguese acronym). Data were collected from questionnaires applied to gynecology and obstetrics residents registered on the SOGESP website in February 2022. The interviewees answered about the repercussions of the pandemic on medical residency and whether they had technical and psychological support during the period. Results A total of 247 questionnaires were collected from residents of gynecology and obstetrics. The residents had an age of 28.3 ± 3 years old, and most of them were female (88.4%). The displacement to COVID care was reported by 62.34% of the students, but only 35.6% reported completely adequate personal protective equipment and only 7.7% reported complete theoretical and technical instruction to support these patients. Almost all of the interviewees stated that the gynecology sector was the most affected. The majority of the interviewees considered that the second-year residents had the greatest loss, and more than half of the residents in the 1st and 2nd year said they wished to give up their residency during the pandemic. More than 80% of the residents reported online theoretical classes and/or presentation of articles, reinforcing the fact that virtual activities gained a greater space within the medical residency. Conclusion The pandemic impacted the residency in greater proportion in outpatient clinics and gynecological surgeries, also interfering with the physician's desire to continue with the program. COVID19 19 COVID-1 Crosssectional Cross sectional SOGESP, (SOGESP acronym. acronym . acronym) 2022 period 24 283 28 28. old 88.4%. 884 88.4% 88 4 (88.4%) 6234 62 34 62.34 students 356 35 6 35.6 77 7 7.7 patients affected secondyear second loss st nd 80 andor or articles surgeries physicians physician s program COVID1 1 COVID- 202 2 88.4 8 (88.4% 623 62.3 35. 7. 20 88. (88.4 62. (88. (88 (8 (

RESUMO A ceratite intersticial é uma inflamação do estroma corneano sem envolvimento epitelial ou endotelial causada principalmente por doenças infecciosas e imunomediadas. O Brasil tem altas taxas de tuberculose que deve ser lembrada como causa de ceratite intersticial. Desnutrição e anemia são fatores de risco da forma disseminada da tuberculose. Este é um relato de uma criança de 10 anos com redução de acuidade visual e diagnóstico clínico de ceratite intersticial bilateral e esclerouveíte. O paciente obteve melhora parcial da ceratite com corticoide tópico. Exames laboratoriais mostraram anemia ferropriva grave, sorologias negativas para HIV e sífilis; IgM negativo e IgG positivo para citomegalovírus e herpes simplex e PPD positivo (17 mm). Ele evoluiu com crises tônico-clônicas e a ressonância nuclear magnética revelou tuberculoma do sistema nervoso central. A melhora da ceratite intersticial foi observada após tratamento para tuberculose. Este é o primeiro caso que descreve a associação de ceratite intersticial e tuberculoma do sistema nervoso central. imunomediadas 1 esclerouveíte tópico grave sífilis 17 (1 mm. mm . mm) tônicoclônicas tônico clônicas central (

ABSTRACT Interstitial keratitis is an inflammation of the corneal stroma without epithelium or endothelium involvement. The underlying causes are mostly infectious or immune mediated. Brazil has one of the highest incidence rates of tuberculosis in the world. Tuberculosis is considered one of the causes of interstitial keratitis. Malnutrition and anemia are risk factors of the disseminated disease. This is a case report of a 10-year-old child who presented with decreased visual acuity and a clinical diagnosis of bilateral interstitial keratitis and sclero-uveitis. The patient had been treated with topical steroids with partial improvement. Examinations revealed severe iron deficiency anemia, negative serologies for human immunodeficiency virus and syphilis, positivity for cytomegalovirus- and herpes simplex-specific IgG, and purified protein derivative of 17 mm. During the follow-up, the patient presented with tonic-clonic seizures, and magnetic resonance imaging findings suggested a central nervous system tuberculoma. Interstitial keratitis improvement was observed after specific tuberculosis treatment. This is the first case report describing the association of interstitial keratitis and central nervous system tuberculoma. involvement mediated world disease 10yearold yearold 10 year old sclerouveitis. sclerouveitis sclero uveitis. uveitis sclero-uveitis syphilis cytomegalovirus simplexspecific simplex IgG 1 mm followup, followup follow up, up follow-up tonicclonic tonic clonic seizures tuberculoma treatment

RESUMO Objetivo: Descrever e comparar as variáveis da aptidão física de acordo com o cumprimento da recomendação de atividade física, medida por acelerometria. Métodos: A amostra foi composta de 120 escolares, sendo 57 meninos e 63 meninas, de 9 a 11 anos de idade. As variáveis analisadas foram: peso, estatura, índice de massa corpórea (IMC), dobras cutâneas, circunferências, agilidade, flexibilidade, velocidade e força de membros superiores, inferiores e abdominal. A atividade física foi mensurada de forma objetiva por meio de acelerômetro. Os escolares foram divididos em dois grupos: “cumpre a recomendação” (≥60min/dia) e “não cumpre a recomendação” (<60min/dia). Para verificar a normalidade dos dados, foi utilizado o teste de Kolmogorov-Smirnov. A comparação dos valores médios dos escolares que cumprem ou não a recomendação de atividade física foi feita pelos testes t de Student e U de Mann-Whitney. O nível de significância adotado foi de p<0,05. Resultados: Os escolares que cumpriram a recomendação, comparados com os que não cumpriram, apresentaram valores significativamente menores para adiposidade (somatória das sete dobras cutâneas), peso corporal, IMC e força abdominal. Não foram encontradas diferenças significativas nas variáveis de velocidade e agilidade; quanto à força de membros superiores (MMSS), constatou-se que ela foi maior em quem não cumpriu a recomendação. Conclusões: Crianças que cumpriram a recomendação de atividade física apresentaram melhor composição corporal e força abdominal que as crianças que não cumpriram.

Abstract Objective: To describe and compare physical fitness variables according to compliance with the recommendations of physical activity, measured by accelerometry. Methods: The sample gathered 120 students, 57 boys and 63 girls aged 9 to 11 years. The variables analyzed were: weight, stature, BMI, skinfolds, waist circumference, agility, flexibility, speed and strength of upper and lower limbs, and abdominal strength. Physical activity was measured objectively using an accelerometer. The students were divided into two groups: “complies with recommendations” (≥60min/day) and “does not comply with recommendations” (<60min/day). To verify the normality of the data, the Kolmogorov-Smirnov test was used. The mean values of students who do or do not comply with the physical activity recommendation were compared using Student's t and U-Mann Whitney tests. The level of significance was set at p<0.05. Results: The students who followed the recommendation showed significantly lower values compared to those who did not for adiposity (sum of 7 skinfolds); body weight; body mass index (BMI) and abdominal strength. No significant differences were found in the variables of speed and agility, and the upper limbs’ strength was greater in subjects who did not comply with recommendations. Conclusions: Students who complied with physical activity recommendations had better body composition and more abdominal strength than those who did not.