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Abstract Prostate cancer (PCa) is a highly prevalent condition among men worldwide, resulting in reduced quality of life and increased costs to health systems due to hospitalization and death. This study aimed to explore and understand the evolution of PCa in Brazil from 2008 to 2018. Data were obtained from the National Health System Department of Informatics (DATASUS) using code C61 for malignant prostatic neoplasms. We presented the hospitalization and mortality rates in a temporal-, regional- and age-dependent manner. From 2008 to 2018, a year-dependent increase in hospital admissions due to PCa was reported in Brazil, in which the Southeast region showed the highest prevalence. Men aged ≥80 and those 70-79 years old had similar hospitalization rates, followed by men aged 60-69, 50-59, 40-49 and 30-39 years old. Similarly, an increase in deaths due to PCa was reported during this period, with the highest rates seen in the Southeast. Men aged ≥80 years had higher mortality rates, followed by those aged 70-79, 60-69, 50-59, 40-49 and 30-39 years old. The results obtained indicate an age- and region-dependent increase in PCa morbidity and mortality in Brazil overtime and may contribute to the ongoing discussion on the role and future perspective of the health care system in Brazil. (PCa worldwide death 200 2018 DATASUS (DATASUS C C6 neoplasms temporal, temporal , temporal- regional agedependent age dependent manner yeardependent year prevalence 80 ≥8 7079 70 79 70-7 6069, 6069 60 69, 69 60-69 5059, 5059 50 59, 59 50-59 4049 40 49 40-4 3039 30 39 30-3 Similarly period 7079, 79, regiondependent 20 201 8 ≥ 707 7 70- 606 6 60-6 505 5 50-5 404 4 40- 303 3 30- 2 60- 50-

https://doi.org/10.1590/s2175-97902024e23366

Helminths of Wied’s marmoset (Callithrix kuhlii (Coimbra-Filho, 1985) (Primates: Callitrichidae)) from the Atlantic Forest, Southern Bahia State, Brazil Wieds Wied s Callithrix CoimbraFilho, CoimbraFilho Coimbra Filho, Filho (Coimbra-Filho 1985 Primates (Primates Callitrichidae Callitrichidae) Forest State 198 19 1
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Soares, Aléxia David Santos

; Silva, Márcio Borba da

; Fraga, Ricardo Evangelista

; Hoppe, Estevam Guilherme Lux

; Oliveira, Wilson Junior

; Schiavetti, Alexandre

Revista Brasileira de Parasitologia Veterinária

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2024, Volume 33 Nº 1 elocation e016523

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Callithrix kuhlli é encontrado em mosaicos florestais, habitats de borda e campos abandonados da Mata Atlântica. Na Bahia e Minas Gerais. O objetivo do trabalho foi identificar helmintos recuperados de C. kuhlli e relacioná-los aos dados clínicos, pesos e índices provenientes do fígado e das gônadas. Foram realizadas necropsias em 13 saguis adultos atropelados na rodovia BA-001 e realizada uma análise de componentes principais (PCA), para descrever as relações entre as variáveis. Recuperou-se 51 helmintos em 30,77% (4/13) dos saguis analisados. A classificação dos helmintos ocorreu por meio das características morfológicas e morfométricas, sendo Primasubulura jacchi (Marcel, 1857), Platynosomum illiciens (Dougherty, 1946) e Prosthenorchis confusus (Dougherty, 1946) as espécies identificadas, com prevalências de 7,69%; 7,69% e 15,38% respectivamente. Ainda, P. confusus apresenta um novo registro de hospedeiro. Já os dois eixos principais da PCA explicaram alta variabilidade (PCA=67,7%), verificando nos animais parasitados uma redução do peso e índices provenientes dos órgãos. Este trabalho amplia o conhecimento sobre parasitos do C. kuhlli e o grau de vulnerabilidade aos parasitas, contribuindo para uma possível construção de perfil epidemiológico da saúde ambiental. florestais Atlântica Gerais C relacionálos relacioná los clínicos gônadas 1 BA001 BA 001 BA-00 PCA, , (PCA) variáveis Recuperouse Recuperou se 5 3077 30 77 30,77 4/13 413 4 (4/13 analisados morfométricas Marcel, Marcel (Marcel 1857, 1857 1857) Dougherty, Dougherty (Dougherty 1946 identificadas 769 7 69 7,69 1538 15 38 15,38 respectivamente Ainda P hospedeiro PCA=67,7%, PCA677 PCA=67,7% 67 (PCA=67,7%) órgãos parasitas ambiental BA00 00 BA-0 (PCA 307 3 30,7 4/1 41 (4/1 185 194 76 6 7,6 153 15,3 PCA67 PCA=67,7 (PCA=67,7% BA0 0 BA- 30, 4/ (4/ 18 19 7, 15, PCA6 PCA=67, (PCA=67,7 (4 PCA=67 (PCA=67, ( PCA=6 (PCA=67 PCA= (PCA=6 (PCA=

Abstract Callithrix kuhlii is present in forest mosaics, edge habitats, and abandoned fields in the Atlantic Forest. In Bahia and Minas Gerais. This study aimed to identify helminths from C. kuhlii and relate them to the clinical data, weights, and indices of the liver and gonads. Necropsies were performed on 13 adult marmosets that were run over on the BA-001 highway. A principal component analysis (PCA) was conducted to describe the relationships between the variables investigated. Fifty-one helminths were collected from 30.77% (4/13) of the marmosets analyzed. Helminths were classified based on their morphological and morphometric characteristics. Primasubulura jacchi (Marcel, 1857), Platynosomum illiciens (Dougherty, 1946), and Prosthenorchis confusus (Dougherty, 1946) were the species identified, with prevalence rates of 7.69%, 7.69%, and 15.38%, respectively. In addition, this is a new host record of P. confusus. The two main axes of the PCA explained a high variability (PCA=67.7%), indicating reduced weight and indices of the organs of parasitized animals. This study expands the knowledge on parasites of C. kuhlii and its vulnerability to parasites, contributing to constructing an epidemiological profile of environmental health. mosaics habitats Forest Gerais C data weights gonads 1 BA001 BA 001 BA-00 highway (PCA investigated Fiftyone Fifty one 3077 30 77 30.77 4/13 413 4 (4/13 analyzed characteristics Marcel, Marcel (Marcel 1857, 1857 , 1857) Dougherty, Dougherty (Dougherty 1946, 1946 identified 769 7 69 7.69% 1538 15 38 15.38% respectively addition P PCA=67.7%, PCA677 PCA=67.7% 67 (PCA=67.7%) animals health BA00 00 BA-0 307 3 30.7 4/1 41 (4/1 185 194 76 6 7.69 153 15.38 PCA67 PCA=67.7 (PCA=67.7% BA0 0 BA- 30. 4/ (4/ 18 19 7.6 15.3 PCA6 PCA=67. (PCA=67.7 (4 7. 15. PCA=67 (PCA=67. ( PCA=6 (PCA=67 PCA= (PCA=6 (PCA=

https://doi.org/10.1590/s1984-29612024011

Diretrizes da Sociedade Brasileira de Angiologia e Cirurgia Vascular para o tratamento da doença cerebrovascular extracraniana
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Ristow, Arno von Buettner

; Massière, Bernardo

; Meirelles, Guilherme Vieira

; Casella, Ivan Benaduce

; Morales, Marcia Maria

; Moreira, Ricardo Cesar Rocha

; Procópio, Ricardo Jayme

; Oliveira, Tércio Ferreira

; Araujo, Walter Jr. Boim de

; Joviliano, Edwaldo Edner

; Oliveira, Júlio Cesar Peclat de

Jornal Vascular Brasileiro

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2024, Volume 23 elocation e20230094

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A doença cerebrovascular extracraniana tem sido intensamente investigada em todo o mundo, sendo tema de suma importância para os cirurgiões vasculares. A presente Diretriz foi elaborada pela Sociedade Brasileira de Angiologia e Cirurgia Vascular (SBACV) em sucessão à Diretriz de 2015. As doenças de etiologia não ateroscleróticas não foram incluídas nesse documento. O objetivo desta Diretriz é congregar as evidências mais robustas nessa área para auxiliar os especialistas no processo decisório do tratamento. Foi utilizada a metodologia AGREE II e o sistema da Sociedade Europeia de Cardiologia para as recomendações e níveis de evidências. As recomendações foram graduadas de I a III, e os níveis de evidência classificados em A, B e C. A presente Diretriz foi dividida em 11 capítulos, que tratam dos vários aspectos da doença cerebrovascular extracraniana: diagnóstico, tratamentos e complicações, de forma atualizada e com as recomendações propostas pela SBACV. mundo vasculares SBACV (SBACV 2015 documento tratamento III C 1 capítulos diagnóstico complicações 201 20 2

Abstract Extracranial cerebrovascular disease has been the subject of intense research throughout the world, and is of paramount importance for vascular surgeons. This guideline, written by the Brazilian Society of Angiology and Vascular Surgery (SBACV), supersedes the 2015 guideline. Non-atherosclerotic carotid artery diseases were not included in this document. The purpose of this guideline is to bring together the most robust evidence in this area in order to help specialists in the treatment decision-making process. The AGREE II methodology and the European Society of Cardiology system were used for recommendations and levels of evidence. The recommendations were graded from I to III, and levels of evidence were classified as A, B, or C. This guideline is divided into 11 chapters dealing with the various aspects of extracranial cerebrovascular disease: diagnosis, treatments and complications, based on up-to-date knowledge and the recommendations proposed by SBACV. world surgeons SBACV, SBACV , (SBACV) 201 Nonatherosclerotic Non atherosclerotic document decisionmaking decision making process III A B C 1 diagnosis complications uptodate up date (SBACV 20 2

https://doi.org/10.1590/1677-5449.202300941

Geochemistry and U-Pb geochronology of columbite of the Cachoeirinha Deposit, Rondônia Tin Province, Brazil UPb U Pb Deposit Province
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Silva, Raquel Guimarães da

; Souza, Valmir da Silva

; Gonçalves, Guilherme de Oliveira

; Ferreira, Luiza dos Santos

; Santos Júnior, Paulo Sérgio Mendes dos

Brazilian Journal of Geology

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2024, Volume 54 Nº 1 elocation e20230054

Resumo: En | Texto: En | PDF: En

Abstract The Cachoeirinha Sn ± (Nb-Ta) deposit is an important producer of the Rondônia Tin Province. It is inserted in the regional unit named Rondônia Intrusive Suite (995–956 Ma) and hosts granular accumulations of columbite group minerals (CGM) embedded in thick Cenozoic colluvial-alluvial covers. Cachoeirinha CGM have subrounded to angular grains, with irregular to regular internal zoning, micro-inclusion, and exsolution features. They have columbite-(Fe) as the dominant mineral phase, with variation in the Ta/(Ta+Nb) ratio and with Sn, Ti, W, U, Ba, Cr, REE, and V as chemical impurities. It has high total REE content (LREEN depleted, HREEN enriched, Ce and Eu anomalies), δ18O = 2.78‰, and with two U-Pb age groups: 1052 ± 6 and 909 ± 7 Ma. This information indicates that physicochemical oscillations favored the ionic substitutions and resorption mechanisms between Nb ↔ Ta, as well as coupled substitutions with the entry of geochemical impurities, according to the equation: 3(Sn, Ti, U, Si)4+ + (W, Cr)6+ ↔ 2(V, Nb, Ta)5+ + 2(Al, REE)3+ + (Fe, Mn, Ba)2+, at the temperature range between 400° and 500°C. Finally, the Cachoeirinha Sn ± (Nb-Ta) alluvial deposit host ore is related to at least two Neo-Mesoproterozoic magmatic pulses. NbTa Ta (Nb-Ta Province 995–956 995956 995 956 (995–95 Ma (CGM colluvialalluvial colluvial covers grains zoning microinclusion, microinclusion micro inclusion, inclusion micro-inclusion features columbiteFe Fe columbite-(Fe phase Ta/Ta+Nb TaTaNb Ta/ Ta+Nb Ta/(Ta+Nb Ti W U Ba Cr impurities LREEN depleted enriched anomalies, anomalies , anomalies) δO δ O 278 2 78 2.78‰ UPb Pb groups 105 90 equation 3Sn, 3Sn 3 3(Sn Si4+ Si4 Si 4+ 4 Si)4 (W Cr6+ Cr6 6+ Cr)6 2V, 2V V, 2(V Ta5+ Ta5 5+ 5 Ta)5 2Al, 2Al Al Al, 2(Al REE3+ REE3 3+ REE)3 Fe, (Fe Mn Ba2+, Ba2 2+, Ba)2+ 400 500C C 500 500°C Finally NeoMesoproterozoic Neo Mesoproterozoic pulses 995–95 99595 99 95 (995–9 TaNb 27 2.78 10 9 Si) Cr) Ta) REE) Ba2+ 2+ Ba)2 40 50 995–9 9959 (995– 2.7 1 Ba) 995– (995 2. (99 (9 (

https://doi.org/10.1590/2317-4889202420230054

Interaction of a Triruthenium ortho-Metallated Phenazine with Cytochrome P450 Enzymes orthoMetallated ortho Metallated P P45 P4
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Nascimento, Luis Guilherme A. do

; Barbetta, Maike F. S.

; Chaves, Otávio A.

; Oliveira, Anderson R. M. de

; Nikolaou, Sofia

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 10 elocation e-20240136

Resumo: En | Texto: En | PDF: En

The triruthenium ortho-metallated phenazine [Ru3O(CH3COO)5(py)2(dppzCl)]PF6 (1, py = pyridine; dppz-Cl = 7-chlorodipyrido[3,2-a:2’,3’-c]phenazine) is a potential metallo-drug candidate with in vitro anticancer and trypanosomicidal activities. It also showed strong interactions with deoxyribonucleic acid (DNA) and human serum albumin due to the presence of the planar and π-conjugated phenazine in its structure. Pursuing our interest in compound 1 behavior in a biological environment, we described its interaction with the cytochrome P450 (CYP450) enzymes present in human liver microsomes through a preliminary in vitro metabolism assay. This study showed that the human liver microsomes metabolized compound 1 in a concentration dependent manner. A phenotyping study suggests that CYP3A is the primary enzyme involved in the interaction, even though other isoforms metabolized 1 in a minor extent. It is worth mentioning that the results of phenotyping using supersomes should be interpreted cautiously, taking into account the inhibitory effect of the surfactant employed. Blind molecular docking results agreed with the experimental trend, showing the highest interactive profile with the isoforms CYP3A4 and 3A5, and suggested hydrophobic, π-stacking, and hydrogen bonds as the primary intermolecular forces responsible for the protein-compound interaction. orthometallated ortho metallated Ru3OCH3COO5py2dppzClPF6 RuOCHCOOpydppzClPF Ru3O CH3COO 5 2 dppzCl PF6 Ru O CH COO PF [Ru3O(CH3COO)5(py)2(dppzCl)]PF 1, (1 pyridine dppz Cl 7chlorodipyrido3,2a2,3cphenazine 7chlorodipyrido32a23cphenazine chlorodipyridoacphenazine 7 chlorodipyrido 3,2 ,3 c 3 7-chlorodipyrido[3,2-a:2’,3’-c]phenazine metallodrug metallo drug activities DNA (DNA πconjugated π conjugated structure environment P P45 CYP450 CYP (CYP450 assay manner CYPA extent cautiously employed trend 3A5 hydrophobic πstacking, πstacking stacking, stacking π-stacking proteincompound protein OCH dppzClPF Ru3OCH3COO5py2dppzClPF RuO CHCOO ( 7chlorodipyrido3 2a2 3cphenazine cphenazine 32 3, , P4 CYP45 (CYP45 3A 7chlorodipyrido 2a CYP4 (CYP4 (CYP

https://doi.org/10.21577/0103-5053.20240136

Adaptability and stability of sweet potato genotypes in Western São Paulo
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Perrud, Amanda C

; Zeist, André Ricardo

; Silva Júnior, André D

; Leal, Murilo Henrique S

; Pieri, Julia Roberta S de

; Rodrigues Júnior, Nilson

; Oliveira, Guilherme José A

; Garcia Neto, Jair

; Rech, Caroline

; Marian, Francieli

Horticultura Brasileira

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2024, Volume 42 elocation e284621

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A batata-doce (Ipomoea batatas L.) possui grande variabilidade genética que contribui para maior produção e qualidades das raízes. Os agricultores de batata-doce do Oeste Paulista, Brasil, plantam durante as quatro estações e utilizam há duas décadas os mesmos genótipos. Desse modo, são necessárias pesquisas que visem avaliar novos genótipos e indicar os mais promissores. Portanto, objetiva-se identificar a adaptabilidade e estabilidade de genótipos de batata-doce em seis épocas de plantio: Setembro de 2019, Janeiro de 2020, Abril de 2020, Setembro de 2020, Outubro de 2020 e Dezembro de 2020 no Oeste Paulista, por meio da metodologia da regressão linear proposta por Eberhart & Russell (1966) e pelo método Centróide. Avaliou-se 17 genótipos, dois genótipos experimentais do Banco de Germoplasma da Universidade do Oeste Paulista e dois genótipos que são cultivados há mais de duas décadas pelos agricultores (Canadense e Ligeirinha Paulista). A partir dos resultados obtidos, os genótipos Canadense, IAPAR 69 e SCS 272 Marina, podem ser considerados como de ampla adaptação na região Oeste Paulista (ambientes favoráveis e desfavoráveis). Por sua vez, os genótipos UBD 01 e UBD 02 são indicados exclusivamente para ambientes desfavoráveis, enquanto que Ligeirinha Paulista, INIA Arapey, SCS 369 Águas Negras, BRS Rubissol, Brazlândia Branca, Brazlândia Roxa e BRS Amélia são indicados para ambientes favoráveis. batatadoce batata doce Ipomoea L. L raízes Brasil modo promissores Portanto objetivase objetiva se plantio 2019 202 1966 (1966 Centróide Avaliouse Avaliou 1 Canadense Paulista. . Paulista) obtidos 6 27 Marina desfavoráveis. desfavoráveis desfavoráveis) vez 0 Arapey 36 Negras Rubissol Branca 201 20 196 (196 2 3 19 (19 (1 (

ABSTRACT Sweet potato (Ipomoea batatas L.) have great genetic variability that contribute to higher production and root quality. Sweet potato farmers in the Western region of São Paulo state, Brazil, plant during the four seasons and have used the same genotypes for two decades. Thus, research is needed to evaluate new genotypes and indicate the most promising ones. Therefore, the objective of this study was to identify the adaptability and stability of sweet potato genotypes in six planting seasons: September 2019, January 2020, April 2020, September 2020, October 2020, and December 2020 in Western São Paulo using the linear regression methodology proposed by Eberhart & Russell (1966) and the centroid method. We evaluated 17 genotypes, two experimental genotypes from the germplasm bank of the University of Western São Paulo and two genotypes that have been cultivated for more than two decades by farmers (Canadense and Ligeirinha Paulista). The results show that Canadense, IAPAR 69, and SCS 272 Marina can be considered widely adapted in the Western region of São Paulo (favorable and unfavorable environments). In turn, the genotypes UBD 01 and UBD 02 are indicated exclusively for unfavorable environments, while Ligeirinha Paulista, INIA Arapey, SCS 369 Águas Negras, BRS Rubissol, Brazlândia Branca, Brazlândia Roxa, and BRS Amélia are indicated for favorable environments. Ipomoea L. L quality state Brazil Thus ones Therefore 2019 202 1966 (1966 method 1 Canadense Paulista. Paulista . Paulista) 69 27 environments environments) turn 0 Arapey 36 Negras Rubissol Branca Roxa 201 20 196 (196 6 2 3 19 (19 (1 (

https://doi.org/10.1590/s0102-0536-2024-e284621

Field management of yellow melon (Cucumis melo L.) with silicon sources Cucumis L. L
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Porcino, Mirelly Miguel

; Oliveira, Valdeir de Souza

; Silva, Edcarlos Camilo da

; Nunes, Maria Silvana

; Tico, Bárbara Moura

; Holanda, Guilherme Chaves de

; Souza, Mileny dos Santos de

; Nascimento, Luciana Cordeiro do

Acta Scientiarum. Agronomy

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2024, Volume 46 elocation e68231

Resumo: En | Texto: En | PDF: En

ABSTRACT. This study aimed to evaluate the effect of silicon and acibenzolar-S-methyl sources on the development of yellow melon (Cucumis melo L.) in the field and the occurrence of diseases in different years. The treatments consisted ofthe silicon sources Agrosilício® (3 g L−1), Rocksil® (3 g L−1), and Chelal® Si (2 L 100 L−1), the additional treatments acibenzolar-S-methyl (ASM) (2 mM) and the fungicide thiabendazole (400 mL 100 L−1), and a control (sterile distilled water). The following characteristics were evaluated: natural incidence of diseases; gas exchange: CO2 assimilation rate, transpiration, stomatal conductance, internal CO2 concentration, water use efficiency, instantaneous water use efficiency, and carboxylation; postharvest aspects: fruit weight, pulp thickness, pulp firmness, titratable acidity, pH, soluble solids, and vitamin C content; productivity; and the enzymatic activity of peroxidases, polyphenol oxidases, and phenylalanine ammonia-lyase. No significant response was observed for naturally occurring diseases. Treatments with Chelal®Si, Rocksil®, and Thiabendazole® increased photosynthetic and transpiration rates in the yellow melon. The silicon and ASM sources did not influence the physicochemical characteristics or the enzymatic activity of fruits. No effect was observed on the biometric characteristics, productivity, and chemical quality of fruits in both years of cultivation. Si sources increased photosynthetic rate and transpiration. However, no diseases were observed during the experimental period. Leaf spraying with silicon and acibenzolar-S-methyl sources did not influence the biometric characteristics and fruit production of yellow melon. The silicon and acibenzolar-S-methyl sources did not induce an increase in the enzymatic activity of peroxidases, polyphenol oxidase, and phenylalanine ammonia-lyase. Fruit production was higher in 2020. ABSTRACT acibenzolarSmethyl acibenzolar S methyl Cucumis L. Agrosilício 3 ( L−1, L1 L−1 , 1 L−1) Rocksil Chelal 2 10 (ASM mM 400 (40 sterile water. . water) evaluated exchange CO conductance concentration efficiency carboxylation aspects weight thickness firmness acidity pH solids content productivity peroxidases oxidases ammonialyase. ammonialyase ammonia lyase. lyase ammonia-lyase ChelalSi Chelal®Si Thiabendazole cultivation However period oxidase 2020 L− 40 (4 202 4 20

https://doi.org/10.4025/actasciagron.v46i1.68231

Fluoride-modified implant surfaces improves osseointegration in the tibias of rats with induced diabetes Fluoridemodified Fluoride modified
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Oliveira, Guilherme José Pimentel Lopes de

; Fontanari, Lucas Amaral

; Souza, João Antônio Chaves de

; Spin-Neto, Rubens

; Elias, Carlos Nelson

; Marcantonio Junior, Elcio

; Orrico, Silvana Regina Perez

Brazilian Dental Journal

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Out 2023, Volume 34 Nº 5 Páginas 43 - 52

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este estudo avaliou a influência de uma superfície de titânio modificada com flúor na osseointegração em ratos com diabetes induzida. Cento e oitenta ratos foram distribuídos aleatoriamente em 3 grupos com 60 animais cada: Grupo controle (C): Animais sem diabetes; Grupo Diabetes (D): Animais com diabetes induzida descompensada; Grupo Diabetes Controlado (CD): Animais com diabetes induzido controlado pela administração de insulina. O diabetes foi induzido por injeção de estreptozotocina. Cada animal recebeu 2 implantes na metáfise proximal da tíbia, um com superfície usinada (M) e outro com superfície de titânio modificado com flúor (F), após 4 semanas de indução do diabetes. Os animais foram submetidos à eutanásia 2, 4 e 6 semanas após a colocação do implante (n = 20 animais/grupo). A osseointegração foi avaliada pelo teste de torque de remoção do implante e pela análise histométrica dos cortes histológicos não descalcificados: 1) Contato osso-implante (%BIC); 2) Área de tecido ósseo entre as roscas do implante (%BBT). Os implantes com superfície F apresentaram maior torque de remoção do que os implantes com superfície M em todos os grupos. Não houve diferença no %BIC entre os grupos independente da superfície utilizada. A superfície F mostrou tendência a apresentar maiores valores de %BBT para os 3 períodos de avaliação no grupo D. As superfícies de implantes modificadas com flúor não influenciaram nos dados de %BIC e %BBT. Entretanto, essas superfícies aumentaram o travamento dos implantes no tecido ósseo. A hiperglicemia foi associada a menores torques de remoção dos implantes independentemente do tipo de superfície de implante utilizada. cada C (C) D (D) descompensada CD (CD) insulina estreptozotocina tíbia (M F, , (F) n animais/grupo. animaisgrupo animais/grupo . animais/grupo) descalcificados 1 ossoimplante osso BIC (%BIC) BBT (%BBT) utilizada Entretanto (C (D (CD (F (%BIC (%BBT

Abstract This study evaluated the influence of a fluoride-modified titanium surface on osseointegration in rats with induced diabetes. One hundred and eighty rats were randomly allocated into 3 groups with 60 animals each: Control group (C): Animals without diabetes; Diabetes Group (D): Animals with uncontrolled induced diabetes; Controlled Diabetes Group (CD): Animals with diabetes induced controlled by the insulin administration. Diabetes was induced by streptozotocin injection. Each animal received 2 implants in the proximal tibial metaphysis, one with the machined surface (M) and the other one with a fluoride-modified titanium surface (F), after 4 weeks of induction of diabetes. The animals were submitted to euthanasia 2, 4, and 6 weeks after the implant placement (n = 20 animals/group). The osseointegration was evaluated by the implant removal torque test and the histometric analysis of the non-decalcified histological sections: 1) Contact bone/implant (%BIC); 2) Bone tissue area between implant threads (%BBT). Implants with F surface showed a higher removal torque than implants with surface M in all groups. There was no difference in %BIC between the groups regardless of the surface used. The F surface showed a tendency to present higher %BBT values for the 3 evaluation periods in the D group. The fluoride-modified implant surface has no impact on the %BIC and %BBT. However, the fluoride-modified implant surface increases the locking of the implants with the bone. The hyperglycemia was associated with lower removal torque values despite the surfaces of the implant used. fluoridemodified fluoride modified each C (C) (D) CD (CD) administration injection metaphysis (M F, , (F) n animals/group. animalsgroup animals/group . animals/group) nondecalcified non decalcified sections 1 boneimplant bone BIC (%BIC) BBT (%BBT) used However (C (D (CD (F (%BIC (%BBT

https://doi.org/10.1590/0103-6440202305439

Detection of Cutibacterium acnes in Tissue Samples from Clean Primary Shoulder Surgeries – Part II
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Miyazaki, Alberto Naoki

; Salles, Mauro José Costa

; Gonçalves, Guilherme Vieira

; Conte, Luiz Henrique Gallego

; Oliveira, Thomaz Gê de

; Santili, Ana Beatriz Nappi

; Kurihara, Mariana Neri Lucas

; Santos, Ingrid Nayara Marcelino

; Silva, Luciana Andrade da

Revista Brasileira de Ortopedia

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Abr 2023, Volume 58 Nº 2 Páginas 257 - 264

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Pesquisa e identificação de Cutibacterium acnes (C. acnes) e de outros microrganismos em amostras de tecidos profundos coletados em cirurgias limpas de ombro em pacientes que não foram submetidos a nenhum procedimento invasivo articular prévio e que não possuíam antecedentes clínicos de infecção. Métodos Foram analisados os resultados das culturas de amostras de tecidos profundos intraoperatórias de 84 pacientes submetidos à cirurgia limpa primária do ombro. Foram utilizados tubos contendo meio de cultivo para armazenamento e transporte de agentes anaeróbicos, tempo prolongado de incubação e espectrômetro de massa para diagnósticos de agentes bacterianos. Resultados Foi evidenciado o crescimento de bactérias em 34 pacientes (40,4%) dos 84 incluídos no estudo. Desses, 23 apresentavam crescimento de C. acnes em pelo menos uma amostra de tecido profundo coletada, correspondendo a 27,3% do total de pacientes. O segundo agente mais encontrado foi o Staphylococcus epidermidis, presente em 7,2% do total de indivíduos incluídos. Evidenciamos maior relação da positividade de amostras com o gênero masculino, uma média de idade inferior, a ausência de diabetes mellitus, o escore ASA I e a profilaxia antibiótica na indução anestésica com cefuroxima. Conclusões Verificou-se um elevado percentual de isolados de diferentes bactérias em amostras de tecidos de ombros de pacientes submetidos a cirurgias limpas e primárias e sem histórico de infecção anterior. A identificação de C. acnes foi elevada (27,6%) e o Staphylococcus epidermidis foi o segundo agente mais frequente (7,2%). C (C 8 anaeróbicos bacterianos 3 40,4% 404 40 4 (40,4% estudo Desses 2 coletada 273 27 27,3 72 7 7,2 masculino inferior mellitus cefuroxima Verificouse Verificou se anterior 27,6% 276 6 (27,6% 7,2%. . (7,2%) 40,4 (40,4 27, 7, 27,6 (27,6 (7,2% 40, (40, (27, (7,2 (40 (27 (7, (4 (2 (7 (

Abstract Objective Research and identification of Cutibacterium acnes (C. acnes) and other microorganisms in deeptissue samples collected in clean shoulder surgeries of patients who did not undergo any previous invasive joint procedure and who had no clinical history of infection. Methods We analyzed the results of cultures of intraoperative deep tissue samples from 84 patients submitted to primary clean shoulder surgery. Tubes containing culture medium were used for storage and transport of anaerobic agents, prolonged incubation time, and mass spectrometer for diagnosis of bacterial agents. Results Bacteria growth was evidenced in 34 patients (40.4%) of the 84 included in the study. Of these, 23 had growth of C. acnes in at least one sample of deep tissue collected, corresponding to 27.3% of the total patients. The second most common agent was Staphylococcus epidermidis, present in 7.2% of the total individuals included. We showed a higher relationship between sample positivity and males, a lower mean age, absence of diabetes mellitus, ASA I score, and antibiotic prophylaxis in anesthetic induction with cefuroxime. Conclusions A high percentage of isolates of different bacteria was found in shoulder tissue samples of patients undergoing clean and primary surgeries, who had no history of previous infection. Identification of C. acnes was high (27.6%), and Staphylococcus epidermidis was the second most frequent agent (7.2%). C (C infection 8 surgery agents time 3 40.4% 404 40 4 (40.4% study these 2 273 27 27.3 72 7 7.2 males age mellitus score cefuroxime 27.6%, 276 27.6% , 6 (27.6%) 7.2%. . (7.2%) 40.4 (40.4 27. 7. 27.6 (27.6% (7.2% 40. (40. (27.6 (7.2 (40 (27. (7. (4 (27 (7 ( (2

https://doi.org/10.1055/s-0042-1757306

10.

Phenolic Compounds from Leaves of Cariniana estrellensis (Raddi) Kuntze (Lecythidaceae): A Brazilian Atlantic Forest Tree Raddi (Raddi Lecythidaceae (Lecythidaceae) (Lecythidaceae
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Tiepo, Angelica N.

; Coutinho, Isabel D.

; Machado, Guilherme O.

; Oliveira, Halley C.

; Pimenta, José Antonio

; Henning, Liliane Marcia M.

; Colnago, Luiz Alberto

; Stolf-Moreira, Renata

Journal of the Brazilian Chemical Society

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Jan 2023, Volume 34 Nº 1 Páginas 146 - 152

Resumo: En | Texto: En | PDF: En

Cariniana estrellensis (Raddi) Kuntze seedlings have been used in forest restoration programs in the Atlantic Forest biome. However, despite the economic and ecological relevance of this species, to date no general method for rapid identification of primary and secondary metabolites of C. estrellensis leaves has been reported. In this work, we explore the feasibility of using rapid analysis by nuclear magnetic resonance techniques and liquid chromatography coupled to diode array, charged aerosol, and mass detection. The main secondary metabolites identified were hydrolysable tannins, quinic acid, hydroxycinnamic acids (trans-p-coumaric acid, cis p coumaric acid, and trans-ferulic acid), and flavonoids (kaempferol and quercetin derivatives). These compounds are particularly useful as chemotaxonomic markers for the genus Cariniana and for the family Lecythidaceae, and may also be important for pharmacological uses and for the survival of the seedlings in reforestation programs. Raddi (Raddi biome However species C reported work array aerosol detection tannins acid transpcoumaric trans transferulic ferulic , acid) kaempferol derivatives. derivatives . derivatives) Lecythidaceae

https://doi.org/10.21577/0103-5053.20220083

11.

Climate Change Assessment in Brazil: Utilizing the Köppen-Geiger (1936) Climate Classification Brazil KöppenGeiger Köppen Geiger 1936 (1936 193 (193 19 (19 1 (1 (
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Lima, Rafael Fausto de

; Aparecido, Lucas Eduardo de Oliveira

; Torsoni, Guilherme Botega

; Rolim, Glauco de Souza

Revista Brasileira de Meteorologia

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2023, Volume 38 elocation e38230001

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Análises e previsões climáticas indicam mudanças significativas nos elementos climáticos, principalmente na temperatura média global, e variações nos padrões de precipitação, que podem ter efeitos profundos nos ecossistemas e na agricultura. Este estudo tem como objetivo avaliar os impactos das mudanças climáticas no território brasileiro usando a classificação climática de Köppen-Geiger (1936). Foram analisados dados climáticos em 4.942 localidades, abrangendo municípios do Brasil, de 1989 a 2019. Esses dados foram obtidos da plataforma NASA/POWER e complementados com projeções mensais de temperatura e precipitação do modelo BCC-CSM1-1, parte do CMIP5 (Coupled Model Intercomparison Project Phase 5), em quatro cenários de emissões (RCP 2.6, RCP 4.5, RCP 6.0 e RCP 8.5) para os períodos de 2041-2060 e 2061-2080. Os resultados revelam um aumento de temperatura em todos os cenários, com o RCP 8.5 indicando o aumento mais significativo, atingindo 4,30 e 5,42 °C para os períodos de 2041-2060 e 2061-2080, respectivamente. Além disso, o mês menos chuvoso do ano apresenta valores de precipitação superiores a 60 mm, levando ao predomínio da tipologia de clima tropical “A” em 82,94% da avaliação climática atual. Em contrapartida, nos cenários de mudança climática, foram observadas reduções nas áreas com clima temperado típico “C” e expansões nas classes de clima árido “B” e tropical em comparação com o padrão climático atual. Notavelmente, a classe BSh tem uma prevalência de 6,09% e 8,16% para os períodos de 2041-2060 e 2061-2080, respectivamente. As mudanças climáticas observadas sinalizam possíveis desafios para a preservação de espécies no Brasil, pois as temperaturas mais altas podem dificultar sua adaptabilidade a condições mais secas e quentes. Como resultado, são necessárias medidas e estratégias cuidadosas para lidar com as implicações dessas mudanças nas próximas décadas. global agricultura KöppenGeiger Köppen Geiger 1936. 1936 . (1936) 4942 4 942 4.94 localidades Brasil 198 2019 NASAPOWER NASA POWER BCCCSM11, BCCCSM11 BCCCSM BCC CSM1 1, 1 CSM BCC-CSM1-1 CMIP Coupled 5, 5 , 5) 26 2 6 2.6 45 4.5 0 6. 85 8 20412060 2041 2060 2041-206 20612080. 20612080 2061 2080. 2080 2061-2080 8. significativo 430 30 4,3 542 42 5,4 C 20612080, 2080, respectivamente disso mm A “A 8294 82 94 82,94 atual contrapartida “C B “B Notavelmente 609 09 6,09 816 16 8,16 quentes resultado décadas 193 (1936 494 4.9 19 201 BCCCSM1 BCC-CSM1- 2. 4. 2041206 204 206 2041-20 2061208 208 2061-208 43 3 4, 54 829 9 82,9 6,0 81 8,1 (193 49 20 BCC-CSM1 204120 2041-2 206120 2061-20 82, 6, 8, (19 BCC-CSM 20412 2041- 20612 2061-2 (1 2061- (

Abstract Analyses and climate forecasts indicate significant changes in climate elements, particularly the global mean temperature, and variations in rainfall patterns, which can have profound effects on ecosystems and agriculture. This study aims to assess the impacts of climate change on the Brazilian territory using the Köppen-Geiger (1936) climate classification. Climate data were analyzed at 4,942 locations, encompassing municipalities in Brazil from 1989 to 2019. These data were obtained from the NASA/POWER platform and complemented with monthly temperature and rainfall projections from the BCC-CSM1-1 model, part of the CMIP5 (Coupled Model Intercomparison Project Phase 5), under four emission scenarios (RCP 2.6, RCP 4.5, RCP 6.0, and RCP 8.5) for the periods 2041-2060 and 2061-2080. The findings reveal a temperature increase across all scenarios, with RCP 8.5 indicating the most significant rise, reaching 4.30 and 5.42 °C for the periods 2041-2060 and 2061-2080, respectively. Additionally, the least rainy month of the year exhibits precipitation values exceeding 60 mm, leading to the dominance of the tropical climate typology “A” in 82.94% of the current climate assessment. In contrast, under climate change scenarios, reductions in areas with typical temperate climate “C” and expansions in arid climate “B” and tropical climate classes were observed compared to the present climate pattern. Notably, the BSh class has a prevalence of 6.09% and 8.16% for the periods 2041-2060 and 2061-2080, respectively. The observed climate changes signal potential challenges for the preservation of species in Brazil, as higher temperatures may hinder their adaptability to drier and warmer conditions. As a result, careful measures and strategies are needed to address the implications of these changes in the coming decades. elements patterns agriculture KöppenGeiger Köppen Geiger 1936 (1936 classification 4942 4 942 4,94 locations 198 2019 NASAPOWER NASA POWER BCCCSM11 BCCCSM BCC CSM1 1 CSM BCC-CSM1- model CMIP Coupled 5, 5 , 5) 26 2 6 2.6 45 4.5 0 6.0 85 8 20412060 2041 2060 2041-206 20612080. 20612080 2061 2080. 2080 2061-2080 8. rise 430 30 4.3 542 42 5.4 C 20612080, 2080, respectively Additionally mm A “A 8294 82 94 82.94 assessment contrast “C B “B pattern Notably 609 09 6.09 816 16 8.16 conditions result decades 193 (193 494 4,9 19 201 BCCCSM1 BCC-CSM1 2. 4. 6. 2041206 204 206 2041-20 2061208 208 2061-208 43 3 54 5. 829 9 82.9 81 8.1 (19 49 4, 20 BCC-CSM 204120 2041-2 206120 2061-20 82. (1 20412 2041- 20612 2061-2 ( 2061-

https://doi.org/10.1590/0102-77863810001

12.

Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19 COVID19 COVID 19 COVID-1 Brasil COVID1 1 COVID-
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Barbosa, Hannah Cardoso

; Martins, Maria Auxiliadora Parreiras

; Jesus, Jordana Cristina de

; Meira, Karina Cardoso

; Passaglia, Luiz Guilherme

; Sacioto, Manuela Furtado

; Bezerra, Adriana Falangola Benjamin

; Schwarzbold, Alexandre Vargas

; Maurílio, Amanda de Oliveira

; Farace, Barbara Lopes

; Silva, Carla Thais Cândida Alves da

; Cimini, Christiane Corrêa Rodrigues

; Silveira, Daniel Vitorio

; Carazai, Daniela do Reis

; Ponce, Daniela

; Costa, Emanuel Victor Alves

; Manenti, Euler Roberto Fernandes

; Cenci, Evelin Paola de Almeida

; Bartolazzi, Frederico

; Madeira, Glícia Cristina de Castro

; Nascimento, Guilherme Fagundes

; Velloso, Isabela Vasconcellos Pires

; Batista, Joanna d’Arc Lyra

; Morais, Júlia Drumond Parreiras de

; Carvalho, Juliana da Silva Nogueira

; Ruschel, Karen Brasil

; Martins, Karina Paula Medeiros Prado

; Zandoná, Liege Barella

; Menezes, Luanna Silva Monteiro

; Kopittke, Luciane

; Castro, Luís César de

; Nasi, Luiz Antônio

; Floriani, Maiara Anschau

; Souza, Maíra Dias

; Carneiro, Marcelo

; Bicalho, Maria Aparecida Camargos

; Lima, Maria Clara Pontello Barbosa

; Godoy, Mariana Frizzo de

; Guimarães-Júnior, Milton Henriques

; Mendes, Paulo Mascarenhas

; Delfino-Pereira, Polianna

; Ribeiro, Raquel Jaqueline Eder

; Finger, Renan Goulart

; Menezes, Rochele Mosmann

; Francisco, Saionara Cristina

; Araújo, Silvia Ferreira

; Oliveira, Talita Fischer

; Oliveira, Thainara Conceição de

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 2 elocation e20220151

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19. COVID19 COVID 19 COVID-1 doença escassos COVID19. 19. COVID19, 19, 3 cidades 2020 invasivo robusta p005 p 0 05 p<0,05 292 idade 6 4871, 4871 48 71 , (48-71) 57,1%, 571 57,1% 57 57,1%] 273 27 27,3 12 (1-2 vs 020. 020 20 . (0-20)] cerebral desidrogenase fosfoquinase Nterminal N terminal própeptídeo pró independentes RR 203 03 2,03 IC95 IC 1,602,58 160258 1,60 2,58 58 1,60-2,58 1,87IC95% 187IC95 1,87 87 1,87;IC95 1,572,23, 157223 1,57 2,23 23 1,57-2,23) normais COVID1 COVID- 202 p00 p<0,0 29 487 4 7 (48-71 57,1 5 27, (1- 02 (0-20) 2,0 IC9 602 1,602,5 16025 160 1,6 258 2,5 1,60-2,5 87IC95 1,87IC95 187IC9 187 1,8 8 1,87;IC9 572 1,572,23 15722 157 1,5 223 2,2 1,57-2,23 p0 p<0, (48-7 57, (1 (0-20 2, 1,602, 1602 16 1, 25 1,60-2, 87IC9 1,87IC9 187IC 18 1,87;IC 1,572,2 1572 15 22 1,57-2,2 p<0 (48- ( (0-2 1,602 1,60-2 87IC 1,87IC 1,572, 1,57-2, p< (48 (0- 1,60- 1,572 1,57-2 (4 (0 1,57-

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients. COVID19 COVID 19 COVID-1 diseases disease s prognosis scarce inhospital hospital Registry 3 cities MarchSeptember March September 2020 variance p005 p 0 05 p<0.05 2925 925 2,92 6 4871, 4871 48 71 , [48-71] 571 57 57.1 men, men men) 273 27 27.3 12 [1-2 vs 02. 02 . [0-2]) peptide dehydrogenase phosphokinase Nterminal N terminal probrain pro Creactive C reactive predictors RR 203 03 2.03 95 1.602.58 160258 1.60 2.58 58 1.60-2.58 187 87 1.87 1.572.23, 157223 1.57 2.23 23 1.57-2.23) COVID1 COVID- 202 p00 p<0.0 292 92 2,9 487 4 7 [48-71 5 57. 27. [1- [0-2] 20 2.0 9 602 1.602.5 16025 160 1.6 258 2.5 1.60-2.5 18 8 1.8 572 1.572.23 15722 157 1.5 223 2.2 1.57-2.23 p0 p<0. 29 2, [48-7 [1 [0-2 2. 1.602. 1602 16 1. 25 1.60-2. 1.572.2 1572 15 22 1.57-2.2 p<0 [48- [ [0- 1.602 1.60-2 1.572. 1.57-2. p< [48 [0 1.60- 1.572 1.57-2 [4 1.57-

https://doi.org/10.36660/abc.20220151

13.

Process optimization of physicochemical properties of spray-dried Hydrocotyle umbellata L. extract spraydried spray dried L
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Oliveira, Matheus Gabriel de

; Moreira, Guilherme Gomes

; Paz, Andressa Tuane Santana

; Oliveira, Thiago Levi Silva

; Silva, Luís Antônio Dantas

; Conceição, Edemilson Cardoso da

; Borges, Leonardo Luiz

; Silva, Vinicius Barreto da

; Paula, José Realino de

Brazilian Journal of Pharmaceutical Sciences

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2023, Volume 59 elocation e21211

Resumo: En | Texto: En | PDF: En

Abstract Hydrocotyle umbellata L., Araliaceae, is a species that is recommended in Ayurvedic medicine for its effects on the central nervous system, such as anxiolytic and memory-stimulant effects. Despite the medicinal potential of this species, its phytopharmaceutical and technological potential to produce standardized extracts has not been investigated. This study analyzes the influence of spray drying parameters on the contents of the chemical markers (total phenolic, total flavonoid, and hibalactone) and the functional properties of H. umbellata extract. The optimization of drying conditions was performed using a central composite design combined with response surface methodology and desirability function approach. The mathematical models fitted to experimental data indicated that all the evaluated drying parameters significantly influenced the chemical contents. The optimal conditions were: inlet temperature of 120 °C, feed flow rate of 4 mL min-1, and colloidal silicon dioxide:maltodextrin ratio of 16%:4%. Under these conditions, the powder samples had spherical particles and desirable physicochemical and functional properties, such as low water activity and moisture content, good product recovery, reconstitution, and flowability. Thus, spray drying might be a promising technique for processing standardized H. umbellata extracts. L L. Araliaceae system memorystimulant memory stimulant investigated phenolic flavonoid hibalactone H extract approach were 12 C °C min1, min1 min 1, 1 min-1 dioxidemaltodextrin dioxide maltodextrin 16%4%. 164 16% 4%. 16 16%:4% content recovery reconstitution flowability Thus min- 16%4% 4% 16%:4 16%4 16%:

https://doi.org/10.1590/s2175-97902023e21211

14.

Guidelines from the Brazilian society of surgical oncology regarding indications and technical aspects of neck dissection in papillary, follicular, and medullary thyroid cancers papillary follicular
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Farias, Terence

; Kowalski, Luiz Paulo

; Dias, Fernando

; Barreira, Carlos S. Ritta

; Vartanian, José Guilherme

; Tavares, Marcos Roberto

; Vaisman, Fernanda

; Momesso, Denise

; Oliveira, Alexandre Ferreira

; Pinheiro, Rodrigo Nascimento

; Ribeiro, Heber Salvador de Castro

Archives of Endocrinology and Metabolism

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2023, Volume 67 Nº 4 elocation e000607

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: The purpose of these guidelines is to provide specific recommendations for the surgical treatment of neck metastases in patients with papillary, follicular, and medullary thyroid carcinomas. Materials and methods: Recommendations were developed based on research of scientific articles (preferentially meta-analyses) and guidelines issued by international medical specialty societies. The American College of Physicians’ Guideline Grading System was used to determine the levels of evidence and grades of recommendations. The following questions were answered: A) Is elective neck dissection indicated in the treatment of papillary, follicular, and medullary thyroid carcinoma? B) When should central, lateral, and modified radical neck dissection be performed? C) Could molecular tests guide the extent of the neck dissection? Results/conclusion: Recommendation 1: Elective central neck dissection is not indicated in patients with cN0 well-differentiated thyroid carcinoma or in those with noninvasive T1 and T2 tumors but may be considered in T3-T4 tumors or in the presence of metastases in the lateral neck compartments. Recommendation 2: Elective central neck dissection is recommended in medullary thyroid carcinoma. Recommendation 3: Selective neck dissection of levels II–V should be indicated to treat neck metastases in papillary thyroid cancer, an approach that decreases the risk of recurrence and mortality. Recommendation 4: Compartmental neck dissection is indicated in the treatment of lymph node recurrence after elective or therapeutic neck dissection; “berry node picking” is not recommended. Recommendation 5: There are currently no recommendations regarding the use of molecular tests in guiding the extent of neck dissection in thyroid cancer. Objective follicular carcinomas methods preferentially metaanalyses meta analyses meta-analyses societies Physicians answered A B performed C Results/conclusion Resultsconclusion Results conclusion 1 cN welldifferentiated well differentiated T T3T4 TT T3 T4 T3-T compartments 2 3 IIV II V cancer mortality 4 berry picking 5 T3T

https://doi.org/10.20945/2359-3997000000607

15.

Seasonality effect on the physiological and productive responses of crossbred dairy cows to the equatorial Amazon climate
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Costa, Dayana Alves da

; Santos, Vinícius Moreira dos

; Oliveira, Antônia Valcemira Domingos de

; Souza, Clebson Lucas de

; Moreira, Guilherme Rocha

; Rosa, Bruna Laurindo

; Reis, Eduardo Mitke Brandão

; Queiroz, Adriano Melo de

Ciência Animal Brasileira

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2023, Volume 24 elocation e-73559E

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo desse estudo foi avaliar os efeitos sazonais dos meses do ano sobre as respostas fisiológicas e produtivas de vacas leiteiras mestiças criadas em clima amazônico. Foram avaliadas 20 vacas lactantes, alimentadas com pasto de Brachiaria decumbens, com acesso livre a água e suplementação mineral. Foram registrados dados das variáveis climáticas temperatura do ar (TA), umidade relativa do ar (UR), precipitação pluviométrica (PP) e índice de temperatura e Umidade (ITU) durante os meses de janeiro a abril de 2019. Os dados fisiológicos coletados foram: frequência respiratória (FR, mov/min), frequência cardíaca (FC, bat./min), temperatura retal (TR, ºC), temperatura superficial do úbere (TSU, ºC), temperatura superfície corporal (TSC, ºC), temperatura superficial do dorso (TSD, ºC), temperatura superficial da fronte (TSF, ºC) e temperatura superficial da canela (TSCA, °C). Também foi mensurada a produção de leite (PL, kg). Houve diferença significativa (P<0,05) da TSCA e FR com valores variando de 34,8 a 35,5°C e 32,0 a 36,2 mov/min, respectivamente. Não houve diferença significativa (P>0,05) para TSC e os valores observados para PL e ITU foram 3,8; 3,8; 4,6; 4,1 kg e 77,7; 79,7; 80,6; 80,1, respectivamente. Houve efeito sazonal dos meses avaliados sobre a taxa respiratória dos animais, no entanto, isso não alterou a PL nem o ITU. O ambiente amazônico é propício a causar estresse térmico em vacas lactantes mantidas a pasto, sendo necessário o uso de sombreamento para facilitar a capacidade de dissipação de calor corporal desses animais. 2 decumbens mineral TA, TA , (TA) UR, UR (UR) PP (PP (ITU 2019 FR, (FR movmin mov/min mov min mov/min) FC, FC (FC bat./min, batmin bat./min bat bat./min) TR, TR (TR ºC, ºC TSU, TSU (TSU TSC, (TSC TSD, TSD (TSD TSF, TSF (TSF TSCA, (TSCA °C. C °C . °C) PL, (PL kg. kg) P<0,05 P005 P 0 05 (P<0,05 348 34 8 34, 355C 35 5 320 32 32, 362 36 36, respectivamente P>0,05 (P>0,05 3,8 38 3 4,6 46 4 6 41 1 4, 77,7 777 77 7 79,7 797 79 80,6 806 80 801 80,1 animais entanto (TA (UR 201 P<0,0 P00 (P<0,0 P>0,0 (P>0,0 3, 77, 79, 80, P<0, P0 (P<0, P>0, (P>0, P<0 (P<0 P>0 (P>0 P< (P< P> (P> (P

Abstract The objective of this study was to evaluate the seasonal effect of months of the year upon the physiological and productive responses of crossbred dairy cows raised in an Amazonian climate. Twenty lactating cows were evaluated, fed on Brachiaria decumbens pasture, with free access to water and mineral supplementation. Data from climate variables air temperature (AT), relative humidity (RH), rainfall (RA) and temperature and humidity index (THI) were recorded dur ing the months of January to April 2019. The physiological data collected were: respiratory rate (RR, mov/min), heart rate (HR, beats/min), rectal temperature (RT, ºC), udder surface temperature (UST, ºC), body surface temperature (BST, ºC), dorsum surface temperature (DST, ºC), front surface temperature (FST, ºC) and rear shin temperature (RST). Milk production (MP) was also measured. There was a significant difference (P<0.05) of RST and RR with values ranging from 34.8 to 35.5°C and 32.0 to 36.2 mov/min, respectively. There were no significant difference (P>0.05) for BST, and the values for MP and THI were 3.8; 3.8; 4.6; 4.1 kg and 77.7; 79.7; 80.6; 80.1, respectively. It was concluded that there was a seasonal effect of the months of the year evaluated on the respiratory rate of animals, however, it did not change the MP and the THI. The Amazon environment is conducive to causing thermal stress in lactating cows raised on pasture, requiring the use of shading to facilitate the ability of these animals to dissipate heat. pasture supplementation AT, AT , (AT) RH, RH (RH) RA (RA (THI 2019 RR, (RR movmin mov/min mov min mov/min) HR, HR (HR beats/min, beatsmin beats/min beats beats/min) RT, RT (RT ºC, ºC UST, UST (UST BST (BST DST, DST (DST FST, FST (FST RST. . (RST) (MP measured P<0.05 P005 P 0 05 (P<0.05 348 34 8 34. 355C C 35 5 320 32 32. 362 36 2 36. respectively P>0.05 (P>0.05 3.8 38 3 4.6 46 4 6 41 1 4. 77.7 777 77 7 79.7 797 79 80.6 806 80 801 80.1 however heat (AT (RH 201 (RST P<0.0 P00 (P<0.0 P>0.0 (P>0.0 3. 77. 79. 80. 20 P<0. P0 (P<0. P>0. (P>0. P<0 (P<0 P>0 (P>0 P< (P< P> (P> (P

https://doi.org/10.1590/1809-6891v24e-73559e

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