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Abstract This study aimed to assess the influence of streptozotocin (STZ)-induced diabetes on the nociceptive behavior evoked by the injection of hypertonic saline (HS) into the masseter muscle of rats. Forty male rats were equally divided into four groups: a) isotonic saline control, which received 0.9% isotonic saline (IS), (Ctrl-IS); b) hypertonic saline control, which received 5% HS (Ctrl-HS); c) STZ-induced diabetic, which received IS, (STZ-IS); d) STZ-induced diabetic, which received HS (STZ-HS). Experimental diabetes was induced by a single intraperitoneal injection of STZ at dose of 60 mg/kg dissolved in 0.1 M citrate buffer, and 100 μL of HS or IS were injected into the left masseter to measure the nociceptive behavior. Later on, muscle RNA was extracted to measure the relative expression of the following cytokines: cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF-α), and interleukins (IL)-1β, -2, -6, and -10. One-way analysis of variance (ANOVA) was applied to the data (p < 0.050). We observed a main effect of group on the nociceptive response (ANOVA: F = 11.60, p < 0.001), where the Ctrl-HS group presented the highest response (p < 0.001). However, nociceptive response was similar among the Ctrl-IS, STZ-IS, and STZ-HS group (p > 0.050). In addition, the highest relative gene expression of TNF-α and IL-6 was found in the masseter of control rats following experimental muscle pain (p < 0.050). In conclusion, the loss of somatosensory function can be observed in deep orofacial tissues of STZ-induced diabetic rats. STZinduced (HS groups 09 0 9 0.9 , (IS) CtrlIS Ctrl (Ctrl-IS) b 5 CtrlHS (Ctrl-HS) c STZIS (STZ-IS) d STZHS. STZHS . (STZ-HS) 6 mgkg mg kg 01 1 0. buffer 10 cytokines cyclooxygenase2 cyclooxygenase 2 cyclooxygenase- COX2, COX2 COX (COX-2) TNFα, TNFα TNF α (TNF-α) IL1β, IL1β ILβ IL 1β, 1β β (IL)-1β 2, -2 6, -6 10. -10 Oneway One way ANOVA (ANOVA 0.050. 0050 0.050 050 0.050) 1160 11 11.60 0.001, 0001 0.001 001 0.001) 0.001. However CtrlIS, Ctrl-IS STZIS, STZ-IS addition IL6 IL- conclusion (IS (Ctrl-IS (Ctrl-HS (STZ-IS (STZ-HS (COX-2 (TNF-α - -1 005 0.05 05 116 11.6 000 0.00 00 (COX- 0.0 11. (COX

https://doi.org/10.1590/1807-3107bor-2024.vol38.0073

Challenges of prescribing testosterone for sexual dysfunction in women: Number 7 – 2024 women 202 20 2
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Lara, Lucia Alves da Silva

; Pereira, Joice Martins de Lima

; Paula, Stany Rodrigues Campos de

; Oliveira, Flavia Fairbanks Lima de

; Cunha, André Marquez

; Lerner, Théo

; Villar, Yara

; Antoniassi, Gabriela Pravatta Rezende

; Benetti-Pinto, Cristina Laguna

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-FPS07

Resumo: En | Texto: En | PDF: En

https://doi.org/10.61622/rbgo/2024fps07

VIDEOFLUOROSCOPIC EVALUATION OF THE IMPACT OF CAPSULE SIZE AND SUBJECT’S AGE AND GENDER ON CAPSULE SWALLOWING SUBJECTS SUBJECT S
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GUTIERRES, Laís Flavia de Souza

; MONTALDI, Marina Rodrigues

; NASCIMENTO, Weslania Viviane

; DANTAS, Roberto Oliveira

Arquivos de Gastroenterologia

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2024, Volume 61 elocation e23092

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Background: People recurrently have difficulties swallowing solid medications, which can be associated with the size of the medication and the age and gender of individuals. Objective: To evaluate the impact of capsule size and adults’ age and gender on oral and pharyngeal capsule transit during capsule swallows. Methods: Videofluoroscopy was used to measure capsule oral and pharyngeal transit during swallows in 49 healthy individuals (17 men and 32 women), with a mean age of 46 years (ranging from 23 to 88 years). Smaller capsules were filled with 0.50 mL of barium sulfate, and larger capsules were filled with 0.95 mL of barium sulfate; the volume of liquid ingested with the capsules was also quantified in each ingestion. The measurements included the oral preparation time, oral transit time, swallowing reaction time, time to laryngeal vestibule closure, laryngeal vestibule closure duration, pharyngeal transit time, and upper esophageal sphincter opening duration. Results: The capsule size did not influence either the oral or pharyngeal transit time. Increased liquid volume was ingested with larger capsules and by people older than 40 years. The oral transit time was shorter in older adults (60-88 years), and the time to laryngeal vestibule closure was longer in women. Conclusion: The size of large capsules did not make a difference in oral or pharyngeal transit when compared with smaller capsules. The capsule size and the participant’s age influenced the volume of liquid ingested - larger capsules and older individuals required a larger volume. The capsule oral transit was faster in individuals older than 60 years. Background medications Objective Methods 4 17 (1 3 women, women , women) ranging 2 8 . years) 050 0 50 0.5 sulfate 095 95 0.9 ingestion duration Results 6088 (60-8 years, Conclusion participants participant s 6 1 ( 05 5 0. 09 9 608 (60- (60 (6

RESUMO Contexto: Algumas pessoas apresentam recorrentemente dificuldades para engolir medicamentos sólidos, o que pode estar associado ao tamanho do medicamento, à idade e ao gênero dos indivíduos. Objetivo: Avaliar, em adultos, o impacto do tamanho da cápsula, da idade e do gênero no trânsito oral e faríngeo de cápsulas. Métodos: Videofluoroscopia foi utilizada para medir o trânsito oral e faríngeo de cápsulas em 49 indivíduos saudáveis (17 homens e 32 mulheres), com idade média de 46 anos (limites de 23 e 88 anos). Cápsulas menores foram preenchidas com 0,50 mL e cápsulas maiores foram preenchidas com 0,95 mL de sulfato de bário; o volume de líquido ingerido com as cápsulas foi quantificado em cada ingestão. Foram medidos o tempo de preparo oral, tempo de trânsito oral, tempo de reação da deglutição, tempo para fechamento do vestíbulo laríngeo, tempo de fechamento do vestíbulo laríngeo, tempo de trânsito faríngeo e tempo de abertura do esfíncter superior do esôfago. Resultados: O tamanho da cápsula não influenciou o tempo de trânsito oral ou faríngeo. Mais líquido foi ingerido com cápsulas maiores e por pessoas com mais de 40 anos. O tempo de trânsito oral foi menor em idosos (60-88 anos) e o tempo de fechamento do vestíbulo laríngeo foi maior em mulheres. Conclusão: O tamanho da cápsula não influenciou o trânsito oral e faríngeo, porém houve maior volume de líquido ingerido com a cápsula maior e nos mais idosos. O trânsito oral da cápsula foi mais rápido em indivíduos com mais de 60 anos. Contexto sólidos medicamento Objetivo Avaliar adultos Métodos 4 17 (1 3 mulheres, mulheres , mulheres) limites 2 8 . 050 0 50 0,5 095 95 0,9 bário ingestão deglutição esôfago Resultados 6088 (60-8 Conclusão 6 1 ( 05 5 0, 09 9 608 (60- (60 (6

https://doi.org/10.1590/s0004-2803.246102023-92

SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- shedding infectivity SARS-CoV
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Mendes-Correa, Maria Cassia

; Ghilardi, Fábio de Rose

; Salomão, Matias Chiarastelli

; Villas-Boas, Lucy Santos

; Paula, Anderson Vicente de

; Paiao, Heuder Gustavo Oliveira

; Costa, Antonio Charlys da

; Tozetto-Mendoza, Tânia Regina

; Freire, Wilton

; Sales, Flavia Cristina Silva

; Claro, Ingra Morales

; Sabino, Ester Cerdeira

; Faria, Nuno Rodrigues

; Witkin, Steven Sol

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e28

Resumo: En | Texto: En | PDF: En

ABSTRACT This study aimed to provide further insight into the evolutionary dynamics of SARS-CoV-2 by analyzing the case of a 40-year-old man who had previously undergone autologous hematopoietic stem cell transplantation due to a diffuse large B-cell lymphoma. He developed a persistent SARS-CoV-2 infection lasting at least 218 days and did not manifest a humoral immune response to the virus during this follow-up period. Whole-genome sequencing and viral cultures confirmed a persistent infection with a replication-positive virus that had undergone genetic variation for at least 196 days after symptom onset. SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- 40yearold yearold 40 year old Bcell B lymphoma 21 followup follow up period Wholegenome Whole genome replicationpositive replication positive 19 onset SARS-CoV 4 1

https://doi.org/10.1590/s1678-9946202466028

Duloxetine in addition to self-management for painful temporomandibular disorders: a post hoc responder analysis of a randomized, placebo-controlled clinical trial selfmanagement self management disorders randomized placebocontrolled placebo controlled
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FERREIRA, Dyna Mara Araújo Oliveira

; SOARES, Flávia Fonseca Carvalho

; RAIMUNDINI, Amanda Ayla

; BONJARDIM, Leonardo Rigoldi

; COSTA, Yuri Martins

; CONTI, Paulo César Rodrigues

Journal of Applied Oral Science

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2024, Volume 32 elocation e20240035

Resumo: En | Texto: En | PDF: En

Abstract Aim To identify the phenotypic characteristics of individuals with temporomandibular disorders (TMD) who may benefit from adding duloxetine to self-management (SM) strategies. Methodology This was a post hoc exploratory analysis of a randomized, placebo-controlled clinical trial with SM-duloxetine (duloxetine 60 mg/day plus SM strategies for 12 weeks) in adult participants with painful TMD. The primary outcome was the proportion of responders to treatment (individuals with ≥ 30% reduction in pain intensity) in SM-duloxetine and SM-placebo group at week 12. For responder analysis, five phenotyping domains recommended by Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials were assessed: pain, psychological, sleep, quantitative sensory testing, and conditioned pain modulation. Relative risk (RR), 95% confidence intervals (CI), and absolute risk reduction were calculated. Results Among participants treated with SM-duloxetine, severe pain intensity (RR 1.33, 95% CI: 0.56, 3.17), pain disability (RR 1.30, 95% CI: 0.63, 2.67), ≥ 1 painful comorbidity (RR 1.48, 95% CI: 0.57, 3.79), and anxiety symptoms (RR 1.80, 95% CI: 0.75, 4.34) were associated with greater likelihood of response to treatment. Among individuals treated with SM-placebo, only temporal summation of pain was associated with greater likelihood of response to treatment. Conclusion Personalized medicine may be implemented in painful TMD management, and phenotype characteristics related to pain and psychological domains may predict which individuals with painful TMD are more likely to respond to the addition of serotonin and norepinephrine reuptake inhibitors to SM strategies to clinically and significantly reduce pain intensity. (TMD selfmanagement self management (SM randomized placebocontrolled placebo controlled SMduloxetine 6 mgday mg day weeks 30 SMplacebo Methods Measurement assessed sleep testing modulation RR, RR , (RR) 95 CI, CI (CI) calculated SMduloxetine, duloxetine, 133 33 1.33 056 0 56 0.56 3.17, 317 3.17 3 17 3.17) 130 1.30 063 63 0.63 2.67, 267 2.67 2 67 2.67) 148 48 1.48 057 57 0.57 3.79, 379 3.79 79 3.79) 180 80 1.80 075 75 0.75 4.34 434 4 34 SMplacebo, placebo, 9 (CI 13 1.3 05 5 0.5 31 3.1 06 0.6 26 2.6 14 1.4 37 3.7 7 18 8 1.8 07 0.7 4.3 43 1. 0. 3. 2. 4.

https://doi.org/10.1590/1678-7757-2024-0035

Ocimum basilicum L. (basil) presents pro-apoptotic activity in an Ehrlich’s experimental tumor murine model L basil (basil proapoptotic pro apoptotic Ehrlichs Ehrlich s
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Sant’Ana, Phelipe Gabriel dos Santos

; Lima, William Gustavo

; Lopes, Gabriela Francine Martins

; Oliveira, Sabrina Elisa de

; Costa, Guilherme Augusto Ferreira da

; Lima, Luciana Alves Rodrigues dos Santos

; Ferreira, Elisângela Elduina

; Santos, Ivan Carlos dos

; Damázio, Laila Cristina Moreira

; Ribeiro, Rosy Iara Maciel Azambuja

; Pinto, Flávia Carmo Horta

Acta Cirúrgica Brasileira

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2024, Volume 39 elocation e393924

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: This study aimed to evaluate the therapeutic effect of an ethanol extract of Ocimum basilicum L. (EEOb) aerial parts against Ehrlich’s experimental tumor (EET) in mice. Methods: Swiss mice were divided into two groups (control and treated; n = 6). On day 21, all mice were inoculated subcutaneously with 2 × 106 (0.05 mL) EET cells in the left paw for solid tumor development. This study lasted 28 days. Treatment began 24 hours after inoculation with EET. Measurements of dorsoplantar thickness were used to assess tumor growth. The paw pad was collected for histopathological analysis and stained using the argyrophilic nucleolar organizing regions (AgNOR) technique and immunohistochemistry for proliferating cell nuclear antigen, Bcl-2 and Bax. Results: The treatment of animals with EEOb at 100 mg/kg intraperitoneally was able to reduce the growth (Control = 3.7 ± 0.1 mm vs. EEOb = 5.7 ± 0.2 mm) and the number of AgNORs of solid Ehrlich tumor. The antitumor effect of EEOb was associated with the induction of apoptosis of tumoral cell, as suggested by the reduction of the content of Bcl-2 induced by extract. Conclusions: The study demonstrated that daily administration of EEOb is able to reduce the growth of EET by induce apoptosis of tumoral cells. Purpose L (EEOb Ehrlichs s (EET Methods control treated 6. 6 . 6) 21 10 0.05 005 0 05 (0.0 mL development days AgNOR (AgNOR antigen Bcl2 Bcl Bcl- Bax Results mgkg mg kg Control 37 3 7 3. 01 1 0. vs 57 5 5. 02 Conclusions 0.0 00 (0. (0 (

https://doi.org/10.1590/acb393924

Dense fog simulation in southern Brazil using the WRF model with high spatial resolution
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Cardoso, Judith Rodrigues

; Marton, Edilson

; Pinheiro, Flávia Rodrigues

; Cossich, William

; Moraes, Nilton Oliveira

Atmósfera

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2024, Volume 38 elocation 53232

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Fog is an atmospheric phenomenon that reduces horizontal visibility to 1000 m or less. These phenomena affect different human activities, mainly those associated with air, maritime, and road transport. Rio Grande city, located in southern Brazil, has one of the main Brazilian ports, and fog occurrences at this location cause several inconveniences, such as the interruption of port activities and increases in operating costs. Thus, a better understanding of fog formation and dissipation, and the consequent improvement in its forecasts, can bring significant help to the port activities in that region. Therefore, this work seeks to evaluate the WRF model’s ability to simulate fog events in Rio Grande city. Four study cases of dense fogs were performed for this goal, as well as a sensitivity test to select the best vertical resolution configuration of the model. Meteorological data from the Rio Grande pilotage station and the Brazilian Coastal Monitoring System buoys were analyzed. Satellite images and synoptic charts were also analyzed for the study cases. The numerical simulations were performed using the WRF model with three nested domains, where 1 km was the highest horizontal resolution. The Fog Stability Index (FSI) and two estimates of horizontal visibility were evaluated. Simulations show promising results, highlighting the ability of the model to identify the fog occurrence in the area of interest and represent aspects of its dissipation process. Furthermore, it is noteworthy that the FSI and the evaluated visibility estimates were sensitive to the occurrence of the events.

RESUMEN La niebla es un fenómeno atmosférico que reduce la visibilidad horizontal a 1000 m o menos. Este tipo de fenómenos afecta diferentes actividades, especialmente las asociadas con los transportes aéreo, marítimo y terrestre. La ciudad de Rio Grande, ubicada en el sur de Brasil, posee uno de los principales puertos de Brasil, y la ocurrencia de niebla en este lugar provoca inconvenientes como la interrupción de las actividades portuarias y el aumento de los costos operativos. Así, una mejor comprensión de la formación y disipación de la niebla y la mejora de sus pronósticos pueden ayudar a las actividades portuarias en esta región. Por lo tanto, este trabajo busca evaluar la capacidad del modelo WRF para simular eventos de niebla en Río Grande. Para ello se seleccionaron cuatro estudios de caso de niebla intensa, así como una prueba de sensibilidad para seleccionar la mejor configuración de resolución vertical del modelo. Los datos meteorológicos fueron analizados desde la estación de pilotaje de Río Grande y las boyas del Sistema de Monitoreo Costero Brasileño. También se analizaron imágenes satelitales y gráficos sinópticos. Las simulaciones numéricas se realizaron utilizando el modelo WRF con tres dominios anidados, donde la resolución horizontal más alta fue de 1 km. Se evaluaron el índice de estabilidad de la niebla (FSI, por su sigla en inglés) y otras dos estimaciones de visibilidad horizontal. Las simulaciones arrojaron resultados prometedores, destacando la capacidad del modelo para identificar la ocurrencia de niebla en el área de interés, además de representar aspectos de su proceso de disipación. Además, el FSI y las estimaciones de visibilidad fueran sensibles a los eventos.

https://doi.org/10.20937/atm.53232

Análise bibliométrica da produção científica sobre plantas alimentícias não convencionais
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Padilha, Ana Flavia

; Pietrobelli, Silmara Rodrigues

; Pereira, Giovana Faneco

; Finatto, Taciane

; Madeira, Nuno Rodrigo

; Vargas, Thiago de Oliveira

Interações (Campo Grande)

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Abr 2023, Volume 24 Nº 2 Páginas 427 - 443

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Las plantas alimentícias no convencionales (PANC) son plantas espontáneas o cultivadas, capaces de ampliar las fuentes de nutrientes disponibles para la población y promover la soberania y seguridad alimentaria. A pesar del potencial que representan los PANC, la mayoría de las especies nativas de Brasil no forman parte del grupo de alimentos más consumidos en el país. El objetivo de este trabajo fue analizar el estado del arte de la investigación académica relacionada con PANC, utilizando un análisis bibliométrico de la investigación y producción científica mundial sobre el tema. Se identificaron un total de 2.056 artículos a partir de la investigación, con 50 términos de búsqueda, de los cuales 26 arrojaron resultados. Se observó un aumento de publicaciones sobre el tema, especialmente a partir de 1996. La fuente más relevante sobre el tema es el Journal of Ethnobiology and Ethnomedicine. Estados Unidos ocupan el primer lugar en cuanto al número de citas sobre el tema, y Brasil ocupa el puesto 28. Palabras como wild, edible, plant, flowers, food, traditional, indigenous e plants fueron las más citadas en los títulos de los artículos. A pesar del aumento de las investigaciones sobre el tema, el escenario aún es incipiente, considerando la gran cantidad de plantas entendidas como “no convencionales” existentes. PANC (PANC cultivadas alimentaria país 2056 2 056 2.05 5 búsqueda resultados 1996 Ethnomedicine 28 wild edible plant flowers food traditional incipiente existentes 205 05 2.0 199 20 0 2. 19 1

Abstract Unconventional food plants (PANC) are spontaneous or cultivated plants capable of expanding the sources of nutrients available to the population and promoting food sovereignty and security. Despite the potential that PANC represent, most native species in Brazil are not part of the most consumed food group in the country. The objective of this work was to analyze the state of the art of academic research related to PANC, using a bibliometric analysis of research and world scientific production on the subject. A total of 2.056 articles were identified from research with 50 search terms, of which 26 returned results. An increase in publications on the topic was observed, especially since 1996. The most relevant source on the topic is the Journal of Ethnobiology and Ethnomedicine. The United States ranks first in terms of the number of citations on the subject and Brazil ranks 28th. Words such as wild, edible, plant, flowers, food, traditional, indigenous, and plants were the most cited in article titles. Despite the increase in research on the subject, the scenario is still incipient considering the large number of plants understood as “unconventional” existing. (PANC security represent country 2056 2 056 2.05 5 results observed 1996 Ethnomedicine 28th th wild edible plant flowers traditional indigenous titles unconventional “unconventional existing 205 05 2.0 199 20 0 2. 19 1

Resumo As plantas alimentícias não convencionais (PANC) são plantas espontâneas ou cultivadas, capazes de ampliar as fontes de nutrientes disponíveis à população e promover a soberania e segurança alimentar. Apesar do potencial que as PANC representam, as espécies nativas do Brasil, em sua maioria, não fazem parte do grupo de alimentos mais consumidos no país. O objetivo do trabalho foi analisar o estado da arte das pesquisas acadêmicas relacionadas às PANC, utilizando uma análise bibliométrica de pesquisa e produção científica mundial a respeito do tema. Foram identificados 2.056 artigos provenientes de pesquisa, com 50 termos de busca, sendo que, desses, 26 retornaram resultados. Foi observado um aumento em publicações sobre o tema, em especial a partir de 1996. A fonte mais relevante sobre o tema é o Journal of Ethnobiology and Ethnomedicine. Os Estados Unidos ocupam o primeiro lugar em relação ao número de citações sobre a temática, e o Brasil ocupa a 28ª colocação. Palavras como wild, edible, plant, flowers, food, traditional, indigenous e plants foram as mais citadas em títulos dos artigos. Apesar do aumento das pesquisas acerca do tema, o cenário ainda é incipiente, considerando a grande quantidade de plantas compreendidas como “não convencionais” existentes. (PANC cultivadas alimentar representam maioria país 2056 2 056 2.05 5 busca desses resultados 1996 Ethnomedicine temática ª colocação wild edible plant flowers food traditional incipiente existentes 205 05 2.0 199 20 0 2. 19 1

https://doi.org/10.20435/inter.v24i2.3830

Artificial neural networks discriminate lettuce seeds with different levels of thermoinhibition
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Catão, Hugo Cesar Rodrigues Moreira

; Cardoso, Daniel Bonifácio Oliveira

; Maciel, Gabriel Mascarenhas

; Gomes, Luiz Antonio Augusto

; Siquieroli, Ana Carolina Silva

; Neves, Flávia de Oliveira Borges Costa

Journal of Seed Science

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2023, Volume 45 elocation e202345016

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract: The thermoinhibition of lettuce seed germination causes important losses for producers, who do not have thermotolerant commercial cultivars. One of the obstacles has been the scarcity of optimizing techniques capable of efficiently discriminating thermotolerant and thermosensitive cultivars. The aim of this work was to evaluate the use of neural networks to discriminate different levels of thermoinhibition in lettuce seeds. Seeds of 18 cultivars were evaluated for thermoinhibition considering the characteristics of the first and last germination count and germination speed index, in seeds subjected to temperatures of 20, 25, 30 and 35 °C. The remaining seeds, which did not germinate, were subjected to the tetrazolium test. Analyses were performed immediately after seed harvesting and repeated after six months of storage. Discriminant analysis was performed and the Kohonen’s Self-Organizing Map (SOM) was created using Artificial Neural Networks (ANNs). Neural networks discriminate lettuce cultivars and organizes them in terms of seed thermoinhibition tolerance through Kohonen’s Self-Organizing Map. Discriminant analysis consistently identifies the Everglades and Luiza genotypes as tolerant to thermoinhibition. Abstract producers 1 index 20 25 3 C °C germinate test storage Kohonens Kohonen s SelfOrganizing Self Organizing SOM (SOM ANNs. ANNs . (ANNs) 2 (ANNs

Resumo: A termoinibição causa perdas importantes para os produtores, os quais não dispõem de cultivares comerciais com sementes termotolerantes. Há escassez de técnicas otimizadoras capazes de discriminar cultivares termotolerantes e termosensíveis com eficiência. Objetivou-se avaliar o uso de redes neurais para discriminar diferentes níveis de termoinibição em sementes de alface. Foram avaliadas sementes de 18 cultivares quanto à termoinibição considerando às características de primeira e última contagem de germinação e índice de velocidade de germinação, em sementes submetidas às temperaturas de 20, 25, 30 e 35 °C. As sementes remanescentes, que não germinaram, foram submetidas ao teste de tetrazólio. As análises foram realizadas imediatamente após a colheita das sementes e repetidas após seis meses de armazenamento. Uma análise discriminante e o Mapa Auto-Organizável de Kohonen (SOM) por Redes Neurais Artificiais (RNA’s) foram realizados. As redes neurais discriminam as cultivares de alface e as organiza quanto a tolerância a termoinibição das sementes por meio do Mapa Auto-Organizável de Kohonen. A análise discriminante indentifica de maneira coerente o genótipo Everglades e Luiza como tolerantes a termoinibição. Resumo produtores eficiência Objetivouse Objetivou se 1 20 25 3 C °C remanescentes germinaram tetrazólio armazenamento AutoOrganizável Auto Organizável SOM (SOM RNAs RNA s (RNA’s realizados 2

https://doi.org/10.1590/2317-1545v45255086

10.

Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study Solidstate Solid state preformulation pre formulation
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Freitas-Marques, Maria Betânia de

; Almeida, Osmar Patrício

; Silva, Flávia Lidiane Oliveira da

; Araújo, Bárbara Caroline Rodrigues

; Ardisson, José Domingos

; Sebastião, Rita de Cássia de Oliveira

; Mussel, Wagner da Nova

; Yoshida, Maria Irene

; Carneiro, Guilherme

Brazilian Journal of Pharmaceutical Sciences

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2023, Volume 59 elocation e21460

Resumo: En | Texto: En | PDF: En

Abstract Clay minerals are still widely used in pharmaceutical products for human health and cosmetic purposes. Pre-formulation studies were conducted to identify solid-state properties of pink clay, a sample from Diamantina, Brazil. Among the solid properties to be analyzed, we have selected type identification, iron phases, crystallinity, powder flow characteristics, thermal behavior, and non-isothermal phase transition kinetics. The pink clay is composed of (1:1) clay type and kaolinite as the main component. The Mössbauer spectrum of pink clay shows Fe3+(α-Fe2O3) hematite, Fe2+, and Fe3+ with large Δ/2ξq of about 2.80 and 2.69 mm.s-1 respectively, related to iron silicates, most likely pyroxene, and a superparamagnetic Fe3+. Pink clay exhibits poor flow properties. The thermal behavior indicates a phase-transition between 400 - 600 ºC associated with the dehydroxylation of the pink clay system requiring ~300 kJ mol-1, being constant until the process reaches a conversion of ~50% when the energy is enhanced to ~530 kJ mol-1, concluding the whole dehydroxylation process (α=80%). Solid-state properties and characteristics found for the pink clay must be considered for the proper design of formulations. This type of clay shows unique pharmaceutical properties that can be favorably exploited by the cosmetic industry. purposes Preformulation Pre formulation solidstate state Diamantina Brazil analyzed identification phases crystallinity nonisothermal non isothermal kinetics 11 1 (1:1 component Fe3+αFe2O3 Fe3αFe2O3 FeαFeO α Fe2O3 Fe3 Fe O Fe3+(α-Fe2O3 hematite Fe2 Fe2+ Δ2ξq Δξq Δ 2ξq ξq 280 2 80 2.8 269 69 2.6 mm.s1 mms1 mms mm.s mm s mm.s- respectively silicates pyroxene phasetransition 40 60 300 ~30 mol1, mol1 mol 1, mol-1 50 ~50 530 ~53 α=80%. α80 α=80% . (α=80%) Solidstate Solid formulations industry (1: αFe2O3 αFe Fe3+αFe2O Fe3αFe2O FeO Fe2O Fe3+(α-Fe2O 28 8 2. 26 6 s1 4 30 ~3 mol- 5 ~5 53 α8 α=80 (α=80% (1 αFeO αFe2O 3 ~ α=8 (α=80 ( α= (α=8 (α= (α

https://doi.org/10.1590/s2175-97902023e21460

11.

Encapsulation of benznidazole in nanostructured lipid carriers and increased trypanocidal activity in a resistant Trypanosoma cruzi strain
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Silva, Flávia Lidiane Oliveira da

; Marques, Maria Betânia de Freitas

; Yoshida, Maria Irene

; Mussel, Wagner da Nova

; Silveira, João Vinícios Wirbitzki da

; Barroso, Poliana Ribeiro

; Kato, Kelly Cristina

; Martins, Helen Rodrigues

; Carneiro, Guilherme

Brazilian Journal of Pharmaceutical Sciences

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2023, Volume 59 elocation e22111

Resumo: En | Texto: En | PDF: En

Abstract Chagas disease is a neglected parasitic disease caused by Trypanosoma cruzi, whose treatment has remained unsatisfactory for over 50 years, given that it is limited to two drugs. Benznidazole (BZN) is an efficient antichagasic drug used as the first choice, although its poor water-solubility, irregular oral absorption, low efficacy in the chronic phase, and various associated adverse effects are limiting factors for treatment. Incorporating drugs with such characteristics into nanostructured lipid carriers (NLC) is a promising alternative to overcome these limiting obstacles, enhancing drug efficacy and bioavailability while reducing toxicity. Therefore, this study proposed NLC-BZN formulations in different compositions prepared by hot-melt homogenization followed by ultrasound, and the optimized formulation was characterized by FTIR, DRX, DSC, and thermogravimetry. Biological activities included in vitro membrane toxicity (red blood cells), fibroblast cell cytotoxicity, and trypanocidal activity against epimastigotes of the Colombian strain of T. cruzi. The optimized NLC-BZN had a small size (110 nm), negative zeta potential (-18.0 mV), and high encapsulation (1.64% of drug loading), as shown by infrared spectroscopy, X-ray diffraction, and thermal analysis. The NLC-BZN also promoted lower in vitro membrane toxicity (<3% hemolysis), and 50% cytotoxic concentration (CC50) for NLC-BZN in L929 fibroblast cells (110.7 µg/mL) was twice the value as the free BZN (51.3 µg/mL). Our findings showed that the NLC-BZN had higher trypanocidal activity than free BZN against the epimastigotes of the resistant Colombian strain, and this novel NLC-BZN formulation proved to be a promising tool in treating Chagas disease and considered suitable for oral and parenteral administration. cruzi 5 years (BZN choice watersolubility, watersolubility water solubility, solubility water-solubility absorption phase NLC (NLC obstacles Therefore NLCBZN hotmelt hot melt ultrasound FTIR DRX DSC thermogravimetry red cells, , cells) cytotoxicity T 110 (11 nm, nm nm) 18.0 180 18 0 (-18. mV, mV mV) 1.64% 164 1 64 (1.64 loading, loading loading) spectroscopy Xray X ray diffraction analysis <3% 3 (<3 hemolysis, hemolysis hemolysis) CC50 CC (CC50 L L92 110.7 1107 7 (110. µg/mL µgmL µg mL 51.3 513 51 (51. µg/mL. . administration 11 (1 18. (-18 1.64 16 6 (1.6 <3 (< CC5 (CC5 L9 110. 51. (51 ( (-1 1.6 (1. < (CC (5 (- 1.

https://doi.org/10.1590/s2175-97902023e22111

12.

“New life and a new way of living”: social representations of obesity and the weight loss process in women who underwent bariatric surgery New living living”
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Silva, Ana Flávia de Sousa

; Lima, Taiane Freitas

; Leonidas, Carolina

; Japur, Camila Cremonezi

; Penaforte, Fernanda Rodrigues de Oliveira

Estudos de Psicologia (Campinas)

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2023, Volume 40 elocation e200155

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Objective: This qualitative, cross-sectional study aimed to understand the social representations of obesity and the weight loss process in women who underwent bariatric surgery. Methods: Sixteen post-bariatric surgery (between 3 and 12 months post-surgery) women participated in semi-structured, face-to-face and individual interviews. The Thematic Analysis of Braun and Clarke (2006) was carried out to evaluate the data. Results: It were identifying 15 codes, 11 sub-themes, grouped into 3 themes: 1) Obesity: “The monster of contemporary society”; 2) “Today is different from what it was before”: Re-signifying eating; and 3) I’m happy, very happy”: The emergence of a new life. It was observed that the low tolerance to obesity in contemporary times implies the perception that people with obesity not worthy living in society. Thus, bariatric surgery is seen as the solution to the problem, as a way to feel ‘normal’ and visible, through a more socially accepted body. Conclusion: The discourse on health, linked to physical limitations, as the main justification for performing the surgery, seems to be overlaid by esthetic issues in the weight loss process. Objective qualitative crosssectional cross sectional Methods postbariatric post between 1 postsurgery post-surgery semistructured, semistructured semi structured, structured semi-structured facetoface face interviews 2006 (2006 data Results codes subthemes, subthemes sub themes, themes sub-themes Obesity society society” 2 Today before before” Resignifying Re signifying eating Im I m happy happy” life Thus problem ‘normal normal visible body Conclusion health limitations 200 (200 20 (20 (2 (

Resumo Objetivo: Esta pesquisa qualitativa, de corte transversal, objetivou compreender as representações sociais da obesidade e do processo de emagrecimento em mulheres que realizaram cirurgia bariátrica. Método: Dezesseis mulheres no pós-operatório (entre 3 e 12 meses) participaram das entrevistas semiestruturadas, presenciais e individuais. A análise dos dados foi feita pela Análise Temática de Braun e Clarke (2006). Resultados: Foram identificados 15 códigos e 11 subtemas, agrupados em 3 temas: 1) Obesidade: “O monstro da sociedade contemporânea”; 2) “Hoje é diferente do que era antes”: Ressignificando o comer; e 3) “Tô feliz, muito feliz”: O surgimento de uma vida nova. Os temas externalizaram a baixa tolerância às pessoas com obesidade na contemporaneidade, que implica na percepção de que elas não são dignas de conviver em sociedade. Assim, a cirurgia bariátrica é vista como a solução do problema- um meio para sentir-se ‘normal’ e visível, pela aproximação com um corpo mais aceito socialmente. Conclusão: O discurso sobre saúde, atrelado às limitações físicas, como justificativa principal para a realização da cirurgia, parece ser sobreposto pelas questões estéticas no processo de emagrecimento. Objetivo qualitativa transversal Método pósoperatório pós operatório entre 1 meses semiestruturadas individuais 2006. 2006 . (2006) Resultados subtemas Obesidade contemporânea contemporânea” 2 Hoje antes antes” comer Tô feliz feliz” nova contemporaneidade Assim problema sentirse sentir se ‘normal normal visível socialmente Conclusão saúde físicas 200 (2006 20 (200 (20 (2 (

https://doi.org/10.1590/1982-0275202340e200155

13.

American Thyroid Association and Thyroid Imaging Reporting and Data System developed by the American College of Radiology: which one is better at predicting malignancy risk? Radiology risk
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Andrade, Marina Nogueira de

; Costa, Julia Rodrigues

; Sousa, Larissa Murici

; Moreira, Luiz Felipe Guimarães Gualberto

; Oliveira, Rayla Felizardo

; Álvares, Maria Carolina Barbosa

; Maia, Flávia Coimbra Pontes

Revista da Associação Médica Brasileira

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2023, Volume 69 Nº 10 elocation e20221694

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: The aim of this study was to compare the capacity of American Thyroid Association and Thyroid Imaging Reporting and Data System developed by the American College of Radiology in predicting malignancy risk of thyroid nodules and to verify which one is better at avoiding unnecessary fine needle aspiration. METHODS: This was a cross-sectional study with 565 thyroid nodules, followed at a tertiary care hospital, in an iodine-replete area. Those were classified as American Thyroid Association and Thyroid Imaging Reporting and Data System developed by the American College of Radiology systems and stratified according to the Bethesda classification of fine needle aspiration. The values of sensibility, specificity, positive predictive value, and negative predictive value accuracy were calculated. Also, the percentage of unnecessary biopsies was presented. RESULTS: The mean age of the individuals was 58.2±13.5 [26–90] years for benign nodules and 41.7±15.6 [23–66] years for malignant nodules (p=0.002). Regarding gender, 92.6% (n=150) of the individuals with benign nodules and 85.7% (n=06) with malignant nodules were females (p=0.601). For American Thyroid Association, 90.9% of sensibility, 51.4% of specificity, 52.6% of accuracy, 10.2% of positive predictive value, and 98.9% of negative predictive value were found. For Thyroid Imaging Reporting and Data System developed by the American College of Radiology, 90.9% of sensibility, 49.7% of specificity, 52.1% of accuracy, 9.9% of positive predictive value, and 98.9% of negative predictive value were found. .Notably, 12.3% of unnecessary fine needle aspiration were found in American Thyroid Association and 44.4% were found in Thyroid Imaging Reporting and Data System developed by the American College of Radiology. CONCLUSION: Both Thyroid Imaging Reporting and Data System developed by the American College of Radiology and American Thyroid Association are able to predict the malignancy risk of thyroid nodules. Thyroid Imaging Reporting and Data System developed by the American College of Radiology was better at avoiding unnecessary fine needle aspiration. OBJECTIVE METHODS crosssectional cross sectional 56 hospital iodinereplete iodine replete area sensibility specificity calculated Also presented RESULTS 582135 58 2 13 5 58.2±13. 26–90 2690 26 90 [26–90 417156 41 7 15 6 41.7±15. 23–66 2366 23 66 [23–66 p=0.002. p0002 p p=0.002 . 0 002 (p=0.002) gender 926 92 92.6 n=150 n150 n 150 (n=150 857 85 85.7 n=06 n06 06 (n=06 p=0.601. p0601 p=0.601 601 (p=0.601) 909 9 90.9 514 51 4 51.4 526 52 52.6 102 10 10.2 989 98 98.9 497 49 49.7 521 1 52.1 99 9.9 Notably .Notably 123 12 3 12.3 444 44 44.4 CONCLUSION 58213 58.2±13 26–9 269 [26–9 41715 41.7±15 23–6 236 [23–6 p000 p=0.00 00 (p=0.002 92. n=15 n15 (n=15 8 85. n=0 n0 (n=0 p060 p=0.60 60 (p=0.601 90. 51. 52. 10. 98. 49. 9. 12. 44. 5821 58.2±1 26– [26– 4171 41.7±1 23– [23– p00 p=0.0 (p=0.00 n=1 n1 (n=1 n= (n= p06 p=0.6 (p=0.60 582 58.2± [26 417 41.7± [23 p0 p=0. (p=0.0 (n (p=0.6 58.2 [2 41.7 p=0 (p=0. 58. [ 41. p= (p=0 (p= (p

https://doi.org/10.1590/1806-9282.20221694

14.

AGED PEOPLE'S HEALTH NEEDS IN THE FACE OF LONG COVID-19 AND ACCESS TO HEALTH SERVICES PEOPLES PEOPLE S COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Cavalaro, Jessika de Oliveira

; Gallo, Adriana Martins

; Derhun, Flávia Maria

; Marques, Francielle Renata Danielli Martins

; Baccon, Wanessa Cristina

; Pires, Graziele Adrieli Rodrigues

; Salci, Maria Aparecida

; Carreira, Lígia

Texto & Contexto - Enfermagem

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2023, Volume 32 elocation e20230088

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Objetivo: averiguar las necesidades de salud de los adultos mayores que tuvieron Covid-19 prolongado y detalles del acceso al sistema de salud para suplir estos requerimientos. Método: estudio cualitativo y exploratorio realizado con 41 adultos mayores que tuvieron Covid-19 en 2020 y presentaron síntomas residuales 18 meses después de la infección. La recolección de datos tuvo lugar entre febrero y julio de 2022 por medio de entrevistas telefónicas semiestructuradas; en el análisis se utilizaron las técnicas analíticas de codificación inicial y focalizada y la base conceptual se fundamentó en el atributo “Accesibilidad” de la Atención Primaria de la Salud. Resultados: surgieron cuatro categorías en el análisis de los resultados, a saber: Comprender la necesidad de atención profesional; Reconocer los requerimientos que llevaron a los adultos mayores a procurar un servicio de salud; Percibir la disponibilidad de los servicios; y Analizar la capacidad de pago. Conclusión: la población anciana desarrolló requerimientos de la salud específicos relacionados con Covid-19 prolongado y los servicios de salud públicos y privados presentan cierta heterogeneidad en relación al enfoque de esta nueva condición, puesto que la atención basada en directrices propuestas por órganos oficiales no es unánime en los servicios públicos, privados y de Operadoras de Planes de Salud. Objetivo Covid19 Covid 19 Covid-1 Método 4 202 1 infección semiestructuradas Accesibilidad “Accesibilidad Salud Resultados resultados saber profesional pago Conclusión condición Covid1 Covid- 20 2

ABSTRACT Objective: to understand the health needs of aged people who had long Covid-19 and details about access to the health system to meet these demands. Method: an exploratory and qualitative study carried out with 41 aged individuals who had Covid-19 in 2020 and presented residual symptoms 18 months after the infection. Data collection took place between February and July 2022 through semi-structured interviews via telephone calls. In the analysis, initial and focused coding analytical techniques were used and the conceptual basis was grounded on the Primary Health Care “Accessibility” attribute. Results: four categories emerged when analyzing the results, namely: Understanding the need for professional care; Recognizing the demands that led aged people to seek health services; Understanding availability of the services; and Analyzing payment capacity. Conclusion: the aged population has developed specific health demands related to long Covid-19, and public and private health services are heterogeneous in their approach to this new condition, as care based on guidelines proposed by official bodies is not unanimous in public and private services and Health Plan Operators. Objective Covid19 Covid 19 Covid-1 Method 4 202 1 infection semistructured semi structured calls analysis Accessibility “Accessibility attribute Results results namely capacity Conclusion Covid19, 19, condition Operators Covid1 Covid- 20 2

RESUMO Objetivo: conhecer as necessidades de saúde dos idosos que tiveram a Covid longa e o acesso ao sistema de saúde para atender essas demandas. Método: estudo qualitativo exploratório, realizado com 41 idosos que tiveram Covid-19 no ano de 2020 e apresentaram sintomas residuais após 18 meses da infecção. A coleta de dados ocorreu entre fevereiro e julho de 2022 por meio de entrevistas semiestruturadas via telefone. Na análise foram utilizadas as técnicas de codificação inicial e focalizada e a base conceitual se fundamentou no atributo “Acessibilidade” da Atenção Primária à Saúde. Resultados: na análise dos resultados emergiram quatro categorias: Compreendendo a necessidade de atendimento profissional; Reconhecendo as demandas que levaram os idosos a buscar o serviço de saúde; Percebendo a disponibilidade dos serviços; e Analisando a capacidade de pagamento. Conclusão: a população idosa desenvolveu demandas específicas de saúde relacionadas à Covid longa, e os serviços de saúde público e privado possuem heterogeneidade quanto à abordagem dessa nova condição, uma vez que o atendimento pautado em diretrizes propostas por órgãos oficiais não é unânime nos serviços públicos, privados e Operadoras de Plano de Saúde. Objetivo Método exploratório 4 Covid19 19 Covid-1 202 1 infecção telefone Acessibilidade “Acessibilidade Saúde Resultados categorias profissional pagamento Conclusão condição públicos Covid1 Covid- 20 2

https://doi.org/10.1590/1980-265x-tce-2023-0088en

15.

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System. (OMPLs SCC. . (SCC) crosssectional cross sectional North, North (North Northeast CentralWest, CentralWest Central West, West Central-West South. South South) 201 120010 120 010 120,01 20102019, 20102019 , (2010-2019) 69 6 9 6.9 8,321 8321 8 321 (8,32 0.8%, 08 0 (0.8% 95 cases, 4.9%, 49 4 (4.9% 5971 5 971 5,97 1.2%, 12 1 2 (1.2% 1399 399 1,39 Brazils s 64.5%, 645 64.5% 64 (64.5%) located men years level consumption group nonCaucasian non formercurrent former users Institute 99 9.9 Therefore System (SCC 20 12001 01 120,0 2010201 (2010-2019 6. 8,32 832 32 (8,3 0.8% (0.8 4.9% (4.9 597 97 5,9 1.2% (1.2 139 39 1,3 64.5 (64.5% 9. 1200 120, 201020 (2010-201 8,3 83 3 (8, 0.8 (0. 4.9 (4. 59 5, 1.2 (1. 13 1, 64. (64.5 20102 (2010-20 8, (8 0. (0 4. (4 1. (1 (64. (2010-2 ( (64 (2010- (6 (2010 (201 (20 (2

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

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