ABSTRACT Introduction: the plasma concentration of epidermal growth factor may be altered in patients with non-small cell lung cancer and thrombocytopenia/thrombocytosis due to chemotherapy. Objective: to determine the association between platelet plasma concentration and epidermal growth factor plasma concentration in patients with non-small cell lung cancer treated with chemotherapy between March 2019 and February 2020 at Saturnino Lora Provincial Hospital. Methods: a cross-sectional, descriptive and observational study was conducted at Saturnino Lora Provincial Hospital, Santiago de Cuba province, Cuba, between March 2019 and February 2020. The target group comprised 54 patients diagnosed with non-small cell lung cancer treated with chemotherapy. A sample of 12 patients was chosen by simple probability-random sampling: platelet plasma concentration (pre- and post-chemotherapy), epidermal growth factor plasma concentration (pre- and post-chemotherapy), and modification of epidermal growth factor plasma concentration (castration, non-castration) were measured. For data processing, the statistical T-student test and Pearson's linear correlation were applied, as well as the mean and standard deviation as summary and dispersion measures, respectively. Results: a linear relationship of -0.37 before chemotherapy and -0.51 after the chemotherapy was found between platelet and epidermal growth factor plasma concentrations; no statistically significant differences were found. Conclusions: it is concluded that the modification of the plasma concentration of epidermal growth factor has no apparent relationship with the platelet plasma modification, with possible spurious relationship, given by chemotherapy.

RESUMEN Introducción: la concentración plasmática del factor de crecimiento epidérmico pudiera encontrarse alterada en pacientes con cáncer de pulmón de células no pequeñas y trombocitopenia/trombocitosis por quimioterapia. Objetivo: determinar la asociación existente entre la concentración plasmática plaquetaria y la concentración plasmática de factor de crecimiento epidérmico en pacientes con cáncer de pulmón de células no pequeñas tratados con quimioterapia, entre marzo de 2019 y febrero de 2020 en el Hospital Provincial Saturnino Lora. Métodos: se realizó un estudio observacional descriptivo transversal en el Hospital Provincial Saturnino Lora, provincia Santiago de Cuba, Cuba, entre marzo de 2019 y febrero de 2020. El universo estuvo constituido por 54 pacientes con diagnóstico de cáncer pulmonar de células no pequeñas tratados con quimioterapia. Por muestreo probabilístico aleatorio simple se seleccionó una muestra de 12 pacientes. Se midieron las variables: concentración plasmática plaquetaria (pre y post-quimioterapia), concentración plasmática de factor de crecimiento epidérmico (pre y post-quimioterapia), y modificación de la concentración plasmática de factor de crecimiento epidérmico (castración, no castración). Para el procesamiento de los datos se empleó el test estadístico T student y la correlación lineal de Pearson, así como la media y desviación estándar como medidas de resumen y dispersión, respectivamente. Resultados: entre las concentraciones plasmáticas plaquetaria y del factor de crecimiento epidérmico se halló una relación lineal de -0,37 previo a la quimioterapia y de -0,51, posterior a esta; no se encontraron diferencias estadísticamente significativas. Conclusiones: se concluye que la modificación de la concentración plasmática del factor de crecimiento epidérmico no guarda relación aparente con la modificación plasmática plaquetaria, con posible relación espuria, dada por la quimioterapia.

A lagarta-das-fruteiras, Argyrotaenia sphaleropa (Meyrick, 1909) (Lepidoptera: Tortricidae), é uma espécie freqüentemente encontrada danificando a cultura da videira e outras frutíferas de clima temperado na região Sul do Brasil e no Uruguai. Estudou-se a flutuação populacional de A. sphaleropa na cultura da videira com emprego do feromônio sexual sintético. Com base na avaliação semanal de machos de A. sphaleropa capturados em armadilha Delta contendo o feromônio sexual sintético (Z11,13-14Ac + Z11,13-14Al + Z11-14Al na proporção 4:4:1, impregnada em liberadores de borracha na dose de 1.000µg/septo), durante a safra 2003-2004, foram observados quatro picos populacionais na cultura da videira cultivar Cabernet Sauvignon. O primeiro pico populacional ocorreu no início do mês de outubro, o segundo no início de fevereiro, o terceiro teve o acme em meados do mês de março e o quarto no mês de junho. A temperatura média diária e a precipitação pluviométrica não exerceram influência sobre a captura dos insetos nas armadilhas. As informações deste trabalho permitem direcionar as táticas de controle para os períodos em que a população do inseto é mais elevada nos parreirais.

The South American Tortricid Moth (Meyrick, 1909) (Lepidoptera: Tortricidae) is often found damaging vineyards and other temperate fruit orchards, in Southern Brazil and Uruguay. This work was conducted to study the seasonal occurrence of A. sphaleropa adults in vineyards using sexual synthetic pheromone. Based on weekly evaluation of A. sphaleropa adults caught in Delta trap baited with synthetic sexual pheromone (Z11, 13-14Ac + Z11, 13-14Al + Z11-14Al in a ratio of 4:4:1, 1000µg/septum), during 2003/2004 season, it was observed four populational peaks in a Cabernet Sauvignon vineyard. The first populational peak occurred in the beginning of October, the second in the beginning of February, the third occurred in middle of March and the forth in June. There was no significative correlation between medium temperature and pluvial precipitation pluvial on adult catches. Information about seasonal fluctuation can be used for grape growers as a tool to guide insecticide treatments for pest control in vineyards.

A lagarta-das-fruteiras Argyrotaenia sphaleropa (Meyrick) tem causado prejuízos significativos em frutíferas cultivadas no Sul do Brasil com destaque para o caquizeiro, pessegueiro e videira. Neste trabalho, apresenta-se a resposta de machos de A. sphaleropa a diferentes formulações e doses do feromônio sexual sintético e a longevidade das formulações mais eficientes no campo. As formulações contendo Z11,13-14Ac + Z11,13-14Al + Z11-14Al (4:4:1), Z11,13-14Al + Z11,13-14Ac (9:1) e Z11,13-14Ac + Z11,13-14Al (9:1) (1,0 mg/septo) foram as mais eficientes na captura de machos quando comparadas com fêmeas virgens. A dose de 1,0 mg/septo foi significativamente superior a 0,1 mg na captura de A. sphaleropa para as três formulações. A formulação Z11,13-14Ac + Z11,13-14Al + Z11-14Al (4:4:1), na dose de 1,0 mg/septo, foi eficiente por pelo menos 75 dias, enquanto que a Z11,13-14Ac + Z11,13-14Al (9:1) por até 60 dias. Para futuros trabalhos visando o monitoramento de A. sphaleropa com feromônio sexual na cultura do caquizeiro, recomenda-se o emprego das formulações Z11,13-14Ac + Z11,13-14Al + Z11-14Al (4:4:1) na dose de 1,0 mg/septo, substituindo os septos de borracha a cada 75 dias.

Argyrotaenia sphaleropa (Meyrick) has been leading to significative damage in cultivated fruits such as persimmon, peach and grape in Southern Brazil. In the present work, the response of A. sphaleropa males to different formulations and doses of the synthetic sexual pheromone was evaluated, as well as the duration of the most efficient formulations under field conditions. Formulations containing Z11,13-14Ac + Z11,13-14Al + Z11-14Al (4:4:1), Z11,13-14Al + Z11,13-14Ac (9: 1) and Z11,13-14Ac + Z11,13-14Al (9: 1) (1.0 mg/ dispenser) were the most efficient as male attractants when compared to unmated females. The concentration of 1.0 mg/ dispenser was significantly more attractive than the 0.1 mg/ dispenser for the three formulations. The formulation Z11,13-14Ac + Z11,13-14Al + Z11-14Al (4:4:1), at 1.0 mg/dispenser, was efficient for at least 75 days, while the attractiveness of Z11,13-14Ac + Z11,13-14Al (9:1) lasted 60 days. Further field experiments should employ the formulation Z11,13-14Ac + Z11,13-14Al + Z11-14Al (4:4:1) at 1.0 mg/dispenser, being dispensers replaced at 75-days intervals.