Resumen En este artículo se examina el concepto de oralidad en los campos científico y didáctico desde un espacio de interés específico: la oralidad calculada y controlada que se registra en culturas letradas y que necesita mediación didáctica. El nombre oralidad no presenta, en el léxico compartido, la complejidad del nombre escritura debido a que su conceptualización se presenta indirectamente derivada del adjetivo oral. En las ciencias del lenguaje, la oralidad se delimita desde el adjetivo oral como par de la variante oral-escrito, pero sin reducir esta distinción a una categoría mediológica. Desde fuera de los estudios lingüísticos, se expone un posicionamiento superador de la visión de polaridad y homogeneidad de los dominios oralidad y escritura. En las concepciones de docentes de enseñanza secundaria en Argentina, la oralidad se percibe mayormente como modalidad de comunicación homogénea, opuesta a la escritura.

Abstract This article examines the concept of orality in the scientific and didactic fields from a space of specific interest: the calculated and controlled orality that is registered in literate cultures and that needs didactic mediation. The name orality does not present, in the shared lexicon, the complexity of the name writing because its conceptualization is indirectly derived from the adjective oral. In the language sciences, orality is delimited from the oral adjective as a pair of the oral-written variant, but without reducing this distinction to a mediological category. From outside linguistic studies, a position that overcomes the vision of polarity and homogeneity of the orality and writing domains is exposed. In the conceptions of secondary school teachers in Argentina, orality is perceived mostly as a homogeneous communication modality, as opposed to writing.

Résumé Cet article examine le concept d'oralité dans les domaines scientifique et didactique à partir d'un espace d'intérêt spécifique : l'oralité calculée et contrôlée qui est enregistrée dans les cultures lettrées et qui nécessite une médiation didactique. Le substantif oralité ne présente pas, dans le lexique commun, la complexité du substantif écriture car sa conceptualisation se présente indirectement dérivée de l'adjectif oral. Dans les sciences du langage, l'oralité est délimitée à partir de l'adjectif oral comme un couple de la variante oral-écrit, mais sans réduire cette distinction à une catégorie médiologique. En-dehors des études linguistiques, une position est avancée qui dépasse la polarité et l'homogénéité des domaines de l'oral et de l'écrit. Dans les conceptions des enseignants du secondaire en Argentine, l'oralité est perçue principalement comme un mode de communication homogène, par opposition à l'écriture.

Abstract The scope of this article is to analyze public policies and interventions (PPI) prevailing in 2022 at the national level for the prevention of excess weight (overweight and obesity) in the adult population of Mexico, from an intersectional perspective. We performed documental analysis of PPI to prevent excess weight in Mexico in adulthood by applying a methodology for policy analysis based on intersectionality (Intersectionality-Based Policy Analysis Framework). A total of nine PPI were analyzed. The extent to which the PPI design considers an intersectional perspective is heterogeneous in the documents analyzed. In the definition of the problem, we identified two main tendencies, namely reductionist and holistic. Both are combined in a variable way in the PPI, revealing internal contradictions in their design. Most PPI consider relatively few cases of social inequality, and as an additive rather than an intersectional consideration. Overall, the PPI consider social inequalities predominantly in the definition of the problem and, to a far lesser extent, in the proposed solutions and in the consultation and negotiation processes. The consideration of the intersectional nature of the problem of excess weight in PPI is important to address the unequal epidemic of excess weight.

Resumen El objetivo de este artículo es analizar las políticas públicas e intervenciones (PPI) a nivel nacional vigentes a 2022 para la prevención del exceso de peso (sobrepeso y obesidad) en población adulta de México, desde una perspectiva interseccional. Se realizó un análisis documental de las estrategias para prevenir el exceso de peso en México en la adultez. Los documentos fueron analizados aplicando una metodología para el análisis de políticas basado en la interseccionalidad. Un total de 9 PPI fueron analizadas. En el diseño de las mismas operan alcances variables para visibilizar una perspectiva interseccional. En la definición del problema identificamos dos tendencias principales: una tendencia reduccionista y una tendencia holística. Ambas se combinan de manera variable en las PPI, evidenciando contradicciones internas en su diseño. La mayoría de las PPI señalan pocos ejes de desigualdad social, y como aditivos más que interseccionales. Las PPI consideran las desigualdades sociales mayormente en la definición del problema y, en mucho menor medida, en las soluciones y en los procesos de consulta y negociación. La consideración de la naturaleza interseccional de la problemática del exceso de peso en las PPI es importante para abordar la epidémica desigualdad del exceso de peso.

RESUMO A pesquisa sobre o ensino de gêneros textuais orais no nível secundário em Rosário (Argentina), a partir da linha de análise do trabalho docente do interacionismo sociodiscursivo (Bronckart, 2007; Riestra, 2010), mostra que em dezesseis aulas de Línguas e A literatura, a oralidade são ensinadas de forma formalizada e não formalizada (Navarro, 2023a). O objetivo deste artigo é realizar uma análise de conteúdo (Bronckart, 2007) das instruções de tarefas (Riestra, 2008) de três turmas de dezesseis alunos nas quais são indicadas atividades de leitura em voz alta de textos literários. Conclui-se que a realidade do ensino da língua materna no nível secundário apresenta atividades de leitura oral em voz alta que são abordadas a partir de um contrato didático implícito e informal, embora a análise das práticas docentes exponha realidades diversas, cujo estudo e sistematização permitiriam o desenvolvimento de modelos didáticos para alcançar o ensino formalizado. Argentina, Argentina , (Argentina) Bronckart, Bronckart (Bronckart 2007 Riestra 2010, 2010 2010) literatura Navarro, Navarro (Navarro 2023a. 2023a . 2023a) (Riestra 2008 literários Concluise Conclui se informal diversas formalizado (Argentina 200 201 20 2

ABSTRACT The research on the teaching of oral textual genres at the secondary level in Rosario (Argentina), from the line of analysis of the teaching work of socio-discursive interactionism (Bronckart, 2007; Riestra, 2010), shows that in sixteen Language classes and Literature, orality is taught in a formalized and non-formalized way (Navarro, 2023a). The objective of this article is to carry out a content analysis (Bronckart, 2007) of the task instructions (Riestra, 2008) of three classes in which reading aloud activities of literary texts are indicated. It is concluded that the reality of teaching the mother tongue at the secondary level presents oral reading aloud activities that are addressed from an implicit and informal didactic contract, although diverse teaching practices are deployed, the study and systematization of which would allow the development of models. didactics to achieve formalized teaching. Argentina, Argentina , (Argentina) sociodiscursive socio discursive Bronckart, Bronckart (Bronckart 2007 Riestra 2010, 2010 2010) Literature nonformalized non Navarro, Navarro (Navarro 2023a. 2023a . 2023a) (Riestra 2008 indicated contract deployed models (Argentina 200 201 20 2

RESUMEN La investigación sobre la enseñanza de los géneros textuales orales en el nivel secundario en Rosario (Argentina), desde la línea de análisis del trabajo docente del interaccionismo socio-discursivo (Bronckart, 2007; Riestra, 2010), muestra que en dieciséis clases de Lengua y Literatura la oralidad se enseña de manera formalizada y no formalizada (Navarro, 2023a). El objetivo de este artículo es realizar un análisis de contenido (Bronckart, 2007) de las consignas de tareas (Riestra, 2008) de tres clases de dieciséis en las que se indican actividades de lectura en voz alta de textos literarios. Se concluye que la realidad de la enseñanza de la lengua materna en el nivel secundario presenta actividades orales de lectura en voz alta que se abordan desde un contrato didáctico implícito e informal, aunque el análisis de las prácticas de enseñanza expone realidades diversas, cuyo estudio y sistematización permitiría elaborar modelos didácticos para concretar una enseñanza formalizada. Argentina, Argentina , (Argentina) sociodiscursivo socio discursivo Bronckart, Bronckart (Bronckart 2007 Riestra 2010, 2010 2010) Navarro, Navarro (Navarro 2023a. 2023a a . 2023a) (Riestra 2008 literarios informal diversas (Argentina 200 201 20 2

ABSTRACT Objective: To measure the costs of preventive and therapeutic protocols of Photobiomodulation (PBM) for oral mucositis (OM) and their budgetary impact on Brazil’s Ministry of Health (BMH). Material and Methods: A partial economic analysis was performed to estimate the costs using a bottom-up approach from a social perspective. Monetary values were assigned in Brazilian reais (BRL). The costs of the preventive protocol were calculated for five, 30, and 33 consecutive PBM sessions, depending on the antineoplastic treatment instituted. The costs of the therapeutic protocol were calculated for 5 or 10 sessions. The annual financial and budgetary impact was calculated considering the groups of oncologic patients with a higher risk of development of OM, such as those with head and neck and hematological cancer and pediatric patients. Results: The cost of a PBM session was estimated at BRL 23.75. The financial impact of providing one preventive protocol per year for all oncologic patients would be BRL 14,282,680.00, 0.030% of the estimated budget for hospital and outpatient care of the BMH in 2022. The financial and budgetary impacts of providing one treatment for OM for all patients in one year would be BRL 2,225,630.31 (0.005%, most optimistic scenario) and BRL 4,451,355.63 (0.009%, most pessimistic scenario). Conclusion: The budgetary impact of implementing PBM protocols in the Brazilian Healthcare System is small, even in a pessimistic scenario. Objective (PBM (OM Brazils Brazil s BMH. . (BMH) Methods bottomup bottom up perspective BRL. (BRL) five 30 3 sessions instituted 1 Results 2375 23 75 23.75 1428268000 14 282 680 00 14,282,680.00 0030 0 030 0.030 2022 222563031 2 225 630 31 2,225,630.3 0.005%, 0005 005 (0.005% scenario 445135563 4 451 355 63 4,451,355.6 0.009%, 0009 009 (0.009% Conclusion small (BMH (BRL 237 7 23.7 142826800 28 68 14,282,680.0 003 03 0.03 202 22256303 22 2,225,630. 0.005% 000 (0.005 44513556 45 35 6 4,451,355. 0.009% (0.009 23. 14282680 14,282,680. 0.0 20 2225630 2,225,630 0.005 (0.00 4451355 4,451,355 0.009 1428268 14,282,680 0. 222563 2,225,63 0.00 (0.0 445135 4,451,35 142826 14,282,68 22256 2,225,6 (0. 44513 4,451,3 14282 14,282,6 2225 2,225, (0 4451 4,451, 1428 14,282, 222 2,225 ( 445 4,451 142 14,282 2,22 44 4,45 14,28 2,2 4,4 14,2 2, 4, 14,

Abstract Background and objective: Anesthesia induction can produce severe propofol dose-dependent hypotension. Fentanyl coadministration reduces the catecholaminergic response to orotracheal intubation allowing propofol dose reduction. The aim of this study is to determine whether the hemodynamic response is improved by increasing the time between fentanyl and propofol administration and reducing the dose of the latter without increasing the time to achieve optimal hypnosis. Methods: After approval by the Research Ethics Committee, patients undergoing non-cardiac surgery with endotracheal intubation were randomized by a computer-generated table into six time-dose groups (1 or 2 minutes/1, 1.5, or 2mg.kg-1 of propofol). Patients with high bronchoaspiration risk, a difficult airway, hemodynamic instability, or anesthetic allergies were excluded. After giving intravenous fentanyl (2 μg.kg-1 ), each group received different doses of propofol after 1 or 2 minutes. Non-invasive blood pressure (BP) and heart rate (HR) were measured at pre-induction, pre-intubation, and post-intubation. Time to hypnosis (bispectral index < 60) was also recorded. Results: Of the 192 recruited patients, 186 completed the study (1 min group n = 94; 2 min group n = 92). It was observed that HR and BP decreased after propofol administration and increased after intubation in all groups (p<0.0001). In patients over 55 years, the 2 min – 2 mg.kg-1 group showed the greatest systolic BP reduction (36 ± 12%) at pre-intubation, while the 1 min – 1.5 mg.kg-1 group showed the least hemodynamic alteration between pre- and post-intubation (-4 ± 13%). No significant differences were found in younger patients or in the time to reach hypnosis between the six groups. While no cases of severe bradycardia were recorded, 5,4% of the sample required vasopressors. Conclusion: Increasing the time between the administration of fentanyl and propofol by up to two minutes results in greater hypotension in patients over 55 years. objective dosedependent dependent Methods Committee noncardiac non cardiac computergenerated computer generated timedose ( minutes1 minutes/1 15 5 2mg.kg1 2mgkg1 mgkg 2mg.kg 2mg kg mg 2mg.kg- propofol. . propofol) risk airway instability excluded μg.kg1 μgkg1 μgkg μg.kg μg μg.kg- , ) Noninvasive Non invasive (BP (HR preinduction, preinduction pre induction, pre-induction preintubation, preintubation intubation, pre-intubation postintubation. postintubation post intubation. bispectral 60 recorded Results 19 18 94 92. 92 92) p<0.0001. p00001 p p<0.0001 0 0001 (p<0.0001) years mg.kg1 mgkg1 mg.kg mg.kg- 36 (3 12% 12 1. 4 (- 13%. 13 13% 13%) 54 5,4 vasopressors Conclusion minutes/ kg1 2mgkg 6 9 p0000 p<0.000 000 (p<0.0001 3 5, p000 p<0.00 00 (p<0.000 p00 p<0.0 (p<0.00 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

ABSTRACT After the acute phase of COVID-19, many patients have persistent symptoms or develop sequelae, which leads them to seek physiotherapy rehabilitation services. Therefore, this study aimed to investigate the knowledge and experience of physiotherapists on the assessment and treatment of post-COVID-19 patients. The cross-sectional observational study was carried out with 73 physiotherapists using an online questionnaire about academic background, areas of expertise, knowledge about COVID-19, and knowledge and experience of assessment and treatment resources in post-COVID-19 rehabilitation, in addition to barriers to the care of these patients in the ambulatory care. Most physiotherapists had heard of post-COVID-19 syndrome, however, only 44% felt sufficiently informed about post-COVID-19 rehabilitation. There was a discrepancy between the degree of importance and experience with the frequency of use of assessment resources, especially the use of specific assessment instruments for skeletal muscle strength, mobility, and respiratory function, in addition to scales and questionnaires to assess disabilities, quality of life, and sleep quality. On the other hand, most reported the importance and had sufficient experience to treat post-COVID-19 patients using cheap and accessible resources. However, less than half use techniques related to respiratory muscle training and/or more sophisticated equipment. Thus, we conclude that most physiotherapists recognize the importance and report sufficient experience to assess and treat post-COVID-19 patients, however, there is a discrepancy between the assessment in the biopsychosocial context of the patient and the treatment process. COVID19, COVID19 COVID 19, 19 COVID-19 sequelae services Therefore postCOVID19 postCOVID post post-COVID-1 crosssectional cross sectional 7 background expertise syndrome however 44 strength mobility function disabilities life hand However andor equipment Thus process COVID1 1 COVID-1 postCOVID1 post-COVID- 4 COVID- post-COVID

RESUMO Após a fase aguda da COVID-19, muitos pacientes apresentam persistência de sintomas ou desenvolvem sequelas, o que os leva a procurar serviços de reabilitação fisioterapêutica. Sendo assim, o objetivo deste estudo foi investigar o conhecimento e a experiência de fisioterapeutas sobre a avaliação e tratamento de pacientes pós-COVID-19. O estudo observacional transversal foi realizado com 73 profissionais, por meio de um questionário online sobre formação acadêmica, áreas de atuação, conhecimento sobre a COVID-19 e experiência sobre recursos de avaliação e tratamento na reabilitação pós-COVID-19, além de barreiras para o atendimento desses pacientes no ambiente ambulatorial. A maioria dos fisioterapeutas já tinham ouvido falar da síndrome pós-COVID-19, no entanto, apenas 44% se sentiam suficientemente informados sobre a reabilitação pós-COVID-19. Houve uma discrepância entre o grau de importância e experiência e a frequência da utilização dos recursos de avaliação, principalmente o uso de instrumentos específicos de avaliação para força muscular esquelética, mobilidade e função respiratória, além de escalas e questionários para avaliar incapacidades, qualidade de vida e qualidade do sono. Em contrapartida, a maioria relatou a importância deste tratamento, alegando ter grau de experiência suficiente para tratar os pacientes pós-COVID-19 com a utilização de recursos baratos e acessíveis. Dessa forma, menos da metade dos profissionais realiza técnicas vinculadas ao treinamento muscular respiratório e/ou equipamentos mais sofisticados. Concluímos, então, que a maioria dos fisioterapeutas reconhece a importância do tratamento de pacientes pós-COVID-19 e relata uma experiência suficiente para avaliá-los e tratá-los, entretanto, há uma discrepância entre o processo de avaliação no contexto biopsicossocial do paciente e o processo de tratamento. COVID19, COVID19 COVID 19, 19 sequelas fisioterapêutica assim pósCOVID19. pósCOVID19 pósCOVID pós 19. 7 acadêmica atuação COVID-1 pósCOVID19, ambulatorial entanto 44 esquelética respiratória incapacidades sono contrapartida pós-COVID-1 acessíveis forma eou sofisticados Concluímos então avaliálos avaliá los tratálos, tratálos tratá los, tratá-los entretanto COVID1 1 pósCOVID1 COVID- 4 pós-COVID- pós-COVID

RESUMEN Terminada la fase aguda de la COVID-19, muchos pacientes presentan síntomas persistentes o desarrollan secuelas, lo que requiere servicios de rehabilitación fisioterapéutica. Ante esto, el objetivo de este estudio fue identificar los conocimientos y la experiencia de los fisioterapeutas respecto a la evaluación y el tratamiento de los pacientes post-COVID-19. Este estudio observacional transversal se llevó a cabo con 73 profesionales, mediante un cuestionario en línea sobre formación académica, áreas de actuación, conocimientos sobre la COVID-19 y experiencia con los recursos de evaluación y tratamiento en la rehabilitación post-COVID-19, además de las barreras para la atención de estos pacientes en el ámbito ambulatorio. Aunque la mayoría de los fisioterapeutas tenían algún conocimiento sobre el síndrome post-COVID-19, solamente el 44% de ellos se sentían suficientemente informados sobre la rehabilitación post-COVID-19. Se observa una discrepancia entre el grado de importancia y experiencia y la frecuencia de uso de los recursos de evaluación, especialmente el uso de herramientas de evaluación específicas para la fuerza muscular esquelética, la movilidad y la función respiratoria, además de escalas y cuestionarios para evaluar la discapacidad, la calidad de vida y la calidad del sueño. Por otro lado, la mayoría informó de la importancia de este tratamiento, afirmando tener experiencia suficiente para tratar a los pacientes post-COVID-19 utilizando recursos baratos y accesibles. Así, menos de la mitad de los profesionales utilizan técnicas vinculadas al entrenamiento de la musculatura respiratoria y/o equipos más sofisticados. Por lo tanto, se concluye que la mayoría de los fisioterapeutas reconocen la importancia de tratar a los pacientes post-COVID-19 y declaran tener experiencia suficiente para evaluarlos y tratarlos; sin embargo, hay una discrepancia entre el proceso de evaluación en el contexto biopsicosocial del paciente y el proceso de tratamiento. COVID19, COVID19 COVID 19, 19 secuelas fisioterapéutica esto postCOVID19. postCOVID19 postCOVID post 19. 7 académica actuación COVID-1 postCOVID19, ambulatorio 44 esquelética discapacidad sueño lado post-COVID-1 accesibles Así yo sofisticados tanto tratarlos embargo COVID1 1 postCOVID1 COVID- 4 post-COVID- post-COVID

Abstract: In vitro fertilization by ovule donation is one of the reproductive technologies used in Cuba. Although reproductive biotechnologies offer possibilities to confront the symbolic order that assumes race as a central element of the kinship intelligibility matrix, in the case of ovule donation, the efforts of the Cuban State are focused on the surveillance of phenotypic marks as a condition for the exchange of reproductive material between ovules donors and receivers. The analysis that we have developed seeks to characterize this racial biopolitics of kinship, its racist presuppositions, which delimit an area of reproductive abjection due to the phenotypic mixtures involved, and the possibilities open to its subversion. The critical dimension that we propose seeks to contribute to anti-racist debates in current cuban society. Abstract Cuba matrix receivers presuppositions involved subversion antiracist anti society

Resumo: A fertilização in vitro por ovodoação é uma das tecnologias reprodutivas empregadas em Cuba. Mesmo que as biotecnologias reprodutivas forneçam possibilidades para confrontar a ordem simbólica que assume a raça como um elemento central da matriz de inteligibilidade do parentesco, no caso da ovodoação, os esforços do Estado cubano se concentram na vigilância das marcas fenotípicas como condição para a troca de material reprodutivo entre doadoras e receptoras de óvulos. A análise que desenvolvemos busca caracterizar essa biopolítica racial do parentesco, seus pressupostos racistas, os quais delimitam um âmbito de abjeção reprodutiva em função das misturas fenotípicas envolvidas, e as possibilidades abertas para a sua subversão. A dimensão crítica que propomos busca contribuir com os debates antirracistas na sociedade cubana atual. Resumo Cuba parentesco óvulos racistas envolvidas subversão atual

Resumen: La fertilización in vitro por ovodonación es una de las tecnologías reproductivas utilizadas en Cuba. Si bien las biotecnologías reproductivas brindan posibilidades para confrontar el orden simbólico que asume la raza como elemento central de la matriz de inteligibilidad del parentesco, en el caso de la donación de óvulos, los esfuerzos del Estado cubano se centran en la vigilancia de las marcas fenotípicas como condición para la el intercambio de material reproductivo entre donantes y receptoras de óvulos. El análisis que hemos desarrollado busca caracterizar esta biopolítica racial del parentesco, sus presupuestos racistas, que delimitan un ámbito de abyección reproductiva por las mezclas fenotípicas involucradas, y las posibilidades abiertas a su subversión. La dimensión crítica que proponemos busca contribuir con los debates antirracistas en la sociedad cubana actual. Resumen Cuba parentesco óvulos racistas involucradas subversión actual

Abstract The scope of this article is to analyze public policies and interventions (PPI) prevailing in 2022 at the national level for the prevention of excess weight (overweight and obesity) in the adult population of Mexico, from an intersectional perspective. We performed documental analysis of PPI to prevent excess weight in Mexico in adulthood by applying a methodology for policy analysis based on intersectionality (Intersectionality-Based Policy Analysis Framework). A total of nine PPI were analyzed. The extent to which the PPI design considers an intersectional perspective is heterogeneous in the documents analyzed. In the definition of the problem, we identified two main tendencies, namely reductionist and holistic. Both are combined in a variable way in the PPI, revealing internal contradictions in their design. Most PPI consider relatively few cases of social inequality, and as an additive rather than an intersectional consideration. Overall, the PPI consider social inequalities predominantly in the definition of the problem and, to a far lesser extent, in the proposed solutions and in the consultation and negotiation processes. The consideration of the intersectional nature of the problem of excess weight in PPI is important to address the unequal epidemic of excess weight. (PPI 202 overweight obesity IntersectionalityBased Intersectionality Based Framework. Framework . Framework) analyzed tendencies holistic inequality Overall processes 20 2

Resumen El objetivo de este artículo es analizar las políticas públicas e intervenciones (PPI) a nivel nacional vigentes a 2022 para la prevención del exceso de peso (sobrepeso y obesidad) en población adulta de México, desde una perspectiva interseccional. Se realizó un análisis documental de las estrategias para prevenir el exceso de peso en México en la adultez. Los documentos fueron analizados aplicando una metodología para el análisis de políticas basado en la interseccionalidad. Un total de 9 PPI fueron analizadas. En el diseño de las mismas operan alcances variables para visibilizar una perspectiva interseccional. En la definición del problema identificamos dos tendencias principales: una tendencia reduccionista y una tendencia holística. Ambas se combinan de manera variable en las PPI, evidenciando contradicciones internas en su diseño. La mayoría de las PPI señalan pocos ejes de desigualdad social, y como aditivos más que interseccionales. Las PPI consideran las desigualdades sociales mayormente en la definición del problema y, en mucho menor medida, en las soluciones y en los procesos de consulta y negociación. La consideración de la naturaleza interseccional de la problemática del exceso de peso en las PPI es importante para abordar la epidémica desigualdad del exceso de peso. (PPI 202 sobrepeso obesidad adultez interseccionalidad analizadas principales holística social interseccionales medida negociación 20 2

Abstract Intermediate metabolism and oxidative balance markers help to better understand environmental dynamics and how they influence the physiological patterns of organisms. Procambarus clarkii (Girard, 1852), a crayfish native to the United States of America and Mexico, represents an appealing case study for understanding invasive species’ metabolic dynamics. This species has sexual dimorphism and two male morphotypes: reproductive (M1) and non-reproductive (M2). We evaluated the seasonal variations of biomarkers in M1 and M2 males, collected in each season of 2016 at Parque Alfredo Volpi (São Paulo, Brazil). Hemolymph, hepatopancreas and abdominal muscle samples were extracted to determine markers of intermediate metabolism, oxidative balance, the hepatosomatic index and the stomach repletion degree. The results showed differences between the two male morphotypes. M1 showed a predominance of medium to full stomachs throughout the year, with an allocation of energetic substrates mainly used in reproduction (gametogenesis and reproductive behaviors). They also presented increased lipoperoxidation, SOD and GST activities. M2, on the other hand, had a lower capacity to allocate energy reserves in the period leading up to and during reproduction, which may be associated with a lower degree of gastric repletion. However, M2 maintained alternating antioxidant strategies that helped preserve low levels of lipoperoxidation in the hepatopancreas throughout the year. This pattern observed for the degree of gastric repletion indicates an intraspecific competition between the categories of males, which, together with the profile of energy reserve usage, seems decisive for M2 to reproduce. organisms Girard, Girard (Girard 1852, 1852 , 1852) Mexico morphotypes M (M1 nonreproductive non M2. . (M2) males 201 São Paulo Brazil. Brazil Brazil) Hemolymph year gametogenesis behaviors. behaviors behaviors) activities hand However usage reproduce 185 (M (M2 20 18 2 1

Abstract Background Cardiovascular diseases (CVDs) are relevant to the management of breast cancer treatment since a substantial number of patients develop these complications after chemotherapy. Objective This study aims to evaluate new cardiovascular biomarkers, namely CXCL-16 (C-X-C motif ligand 16), FABP3 (fatty acid binding protein 3), FABP4 (fatty acid binding protein 4), LIGHT (tumor necrosis factor superfamily member 14/TNFS14), GDF-15 (Growth/differentiation factor 15), sCD4 (soluble form of CD14), and ucMGP (uncarboxylated Matrix Gla-Protein) in breast cancer patients treated with doxorubicin (DOXO). Methods This case-control study was conducted in an oncology clinic that included 34 women diagnosed with breast cancer and chemotherapy with DOXO and 34 control women without cancer and CVD. The markers were determined immediately after the last cycle of chemotherapy. The statistical significance level adopted was 5%. Results The breast cancer group presented higher levels of GDF-15 (p<0.001), while control subjects had higher levels of FABP3 (p=0.038), FABP4 (p=0003), sCD14, and ucMGP (p<0.001 for both). Positive correlations were observed between FABPs and BMI in the cancer group. Conclusion GDF15 is an emerging biomarker with potential clinical applicability in this scenario. FABPs are proteins related to adiposity, which are potentially involved in breast cancer biology. sCD14 and ucMGP engage in inflammatory and vascular calcification. The evaluation of these novel cardiovascular biomarkers could be useful in the management of breast cancer chemotherapy with DOXO. CVDs (CVDs CXCL16 CXCL 16 CXCL-1 CXC C X 16, , 16) FABP fatty 3, 3 3) 4, 4 4) tumor 14/TNFS14, 14TNFS14 TNFS 14/TNFS14 14 TNFS14 14/TNFS14) GDF 15 GDF-1 Growth/differentiation Growthdifferentiation Growth differentiation 15, 15) sCD soluble CD14, CD14 CD CD14) uncarboxylated GlaProtein Gla Protein Gla-Protein . (DOXO) casecontrol case CVD 5 5% p<0.001, p0001 p p<0.001 0 001 (p<0.001) p=0.038, p0038 p=0.038 038 (p=0.038) p=0003, p0003 p=0003 0003 (p=0003) (p<0.00 both. both both) GDF1 scenario adiposity biology sCD1 calcification CXCL1 1 CXCL- 14TNFS1 14/TNFS1 TNFS1 GDF- CD1 (DOXO p000 p<0.00 00 p003 p=0.03 03 (p=0.038 p=000 000 (p=0003 (p<0.0 14TNFS 14/TNFS p00 p<0.0 p=0.0 (p=0.03 p=00 (p=000 (p<0. p0 p<0. p=0. (p=0.0 p=0 (p=00 (p<0 p<0 (p=0. p= (p=0 (p< p< (p= (p

Resumo Fundamento As doenças cardiovasculares (DCV) são relevantes para o manejo do tratamento do câncer de mama, uma vez que um número significativo de pacientes desenvolve essas complicações após a quimioterapia. Objetivo Este estudo teve como objetivo avaliar novos biomarcadores cardiovasculares, sendo eles CXCL-16 (ligante de motivo C-X-C 16), FABP3 (proteína de ligação a ácidos graxos 3), FABP4 (proteína de ligação a ácidos graxos 4), LIGHT (membro da superfamília do fator de necrose tumoral 14/TNFS14), GDF-15 (fator de crescimento/diferenciação 15) , sCD4 (forma solúvel de CD14) e ucMGP (matriz Gla-proteína não carboxilada) em pacientes com câncer de mama tratadas com doxorrubicina (DOXO). Métodos Este estudo de caso-controle foi realizado em uma clínica oncológica, incluindo 34 mulheres com diagnóstico de câncer de mama tratadas com quimioterapia com DOXO e 34 mulheres controle, sem câncer ou DCV. Os marcadores foram determinados imediatamente após o último ciclo de quimioterapia. O nível de significância estatística adotado foi de 5%. Resultados O grupo com câncer de mama apresentou níveis mais elevados de GDF-15 (p<0,001), enquanto os indivíduos controle apresentaram níveis mais elevados de FABP3 (p=0,038), FABP4 (p=0003), sCD14 e ucMGP (p<0,001 para ambos). Correlações positivas foram observadas entre FABPs e IMC no grupo com câncer. Conclusão GDF15 é um biomarcador emergente com potencial aplicabilidade clínica neste cenário. FABPs são proteínas relacionadas à adiposidade, potencialmente envolvidas na biologia do câncer de mama. sCD14 e ucMGP estão envolvidos na calcificação inflamatória e vascular. Acima de tudo, a avaliação destes novos biomarcadores cardiovasculares pode ser útil no tratamento da quimioterapia do câncer de mama com DOXO. DCV (DCV CXCL16 CXCL 16 CXCL-1 ligante CXC C X 16, 16) FABP proteína 3, 3 3) 4, 4 4) membro 14/TNFS14, 14TNFS14 TNFS 14/TNFS14 14 TNFS14 14/TNFS14) GDF 15 GDF-1 crescimentodiferenciação crescimento diferenciação sCD forma CD14 CD matriz Glaproteína Gla carboxilada . (DOXO) casocontrole caso oncológica 5 5% p<0,001, p0001 p p<0,001 0 001 (p<0,001) p=0,038, p0038 p=0,038 038 (p=0,038) p=0003, p0003 p=0003 0003 (p=0003) sCD1 (p<0,00 ambos. ambos ambos) GDF1 cenário adiposidade vascular tudo CXCL1 1 CXCL- 14TNFS1 14/TNFS1 TNFS1 GDF- CD1 (DOXO p000 p<0,00 00 p003 p=0,03 03 (p=0,038 p=000 000 (p=0003 (p<0,0 14TNFS 14/TNFS p00 p<0,0 p=0,0 (p=0,03 p=00 (p=000 (p<0, p0 p<0, p=0, (p=0,0 p=0 (p=00 (p<0 p<0 (p=0, p= (p=0 (p< p< (p= (p

Abstract Introduction: Non-Invasive Mechanical Ventilation (NIV) is one of the most widely used clinical devices in neonates in Neonatal Intensive Care Units (NICU). This has shown its effectiveness in reducing the mortality of these children. However, these systems generate a prolonged pressure in certain anatomical parts of the newborn that favors the appearance of pressure injuries (LPP). It is estimated that almost half of pressure injuries in Neonatal Intensive Care Units are caused by these systems. Objectives: To analyze the incidence and risk factors of pressure injury in neonates at the Neonatal Intensive Care Unit of the Hospital Clinico Universitario de Valencia with Non-Invasive Mechanical Ventilation. Methodology: it is a cohort, observational, analytical, longitudinal and prospective study. Carried out in the neonatal ICU of the Hospital Clínico Universitario de Valencia between the months of February and May 2019. Results: The study sample was 34 neonates, of which 7 (20.59%) developed a pressure injury. Of the total number of patients with injury, 4 (57.1%) were carriers of nasal stems. 3 (42.9%) wore RAM cannulas and no one of patients with High Flow Oxygen Therapy Glasses developed a pressure ulcer. Conclusions: The use of High Flow glasses and RAM Cannulas against nasal stems as a method of reducing the incidence of pressure injuries in neonates with Non-Invasive Mechanical Ventilation.

Resumen Introducción: La ventilación mecánica no invasiva es una técnica de amplio uso en las unidades de cuidados intensivos neonatales que ha demostrado su efectividad en la disminución de la mortalidad. Estos sistemas generan una presión prolongada en la zona de la cara del recién nacido que favorece la aparición de lesiones por presión. Se estima que casi la mitad de las lesiones por presión en las unidades de cuidados intensivos neonatales se producen por estos sistemas. Objetivos: Analizar la incidencia y los factores de riesgo de lesiones por presión en neonatos portadores de ventilación mecánica no invasiva ingresados en la Unidad de Cuidados Intensivos Neonatales del Hospital Clínico Universitario de Valencia. Metodología: Estudio de cohortes, observacional, analítico, longitudinal y prospectivo. Llevado a cabo en la Unidad de Cuidados Intensivos Neonatales del Hospital Clínico Universitario de Valencia entre los meses de febrero y mayo de 2019. Resultados: La muestra del estudio fue de 34 neonatos, de los que 7 (el 20,59%) fueron incidentes de lesiones por presión. Del total de pacientes con lesión, 4 (el 57,1%) eran portadores de vástagos nasales, 3 (el 42,9%) utilizaban cánulas RAM®. Ningún paciente portador de gafas de oxigenoterapia de alto flujo fue incidente de lesiones por presión. Conclusiones: El uso de las gafas de alto flujo y las cánulas RAM® frente a los vástagos nasales fue un método más efectivo en la reducción de la incidencia de lesiones por presión en neonatos portadores de ventilación mecánica no invasiva.

ABSTRACT Objective: To report nine cases of pediatric patients with Acute Lymphoid Leukemia (ALL) or Acute Myeloid Leukemia who developed severe oral mucositis (SOM) at the first week of chemotherapy. Material and Methods: The cases were selected from a sample of 105 children followed for 10 consecutive weeks. Hematological and personal data were obtained from the patient's medical records. The oral cavity was examined weekly using the modified Oral Assessment Guide. Results: More of the patients were male (55.6%), had black/brown skin (55.6%), with ALL (66.7%), and the mean age was 5.55. Two patients had values below normal for leukocytes, platelets, and creatinine over the follow-up. However, all patients showed changes in the normality of hematological data in most weeks. The most used chemotherapeutic agents were aracytin, etoposide, and methotrexate, known for their high stomatotoxic potential. Patients had 2 to 6 (mean of 4) episodes of SOM and 4 to 7 (mean of 5.5) episodes of OM. One patient at week 7, one patient at week 5, and one patient at weeks 2 and 10 did not have OM. Saliva (84 times) and lips (44 times) were the most affected items. Conclusion: The patients showed oscillations in the severity of oral mucositis and hematological parameters over the follow-up. All patients were exposed to stomatotoxic drugs during the initial phase of cancer treatment. Objective (ALL (SOM chemotherapy Methods 1 s records Guide Results 55.6%, 556 55.6% , 55 (55.6%) blackbrown black brown 66.7%, 667 66.7% 66 (66.7%) 555 5 5.55 leukocytes platelets followup. followup follow up. up follow-up However aracytin etoposide methotrexate potential 5.5 OM 84 (8 times 44 (4 items Conclusion treatment 55.6 (55.6% 66.7 (66.7% 5. 8 ( 55. (55.6 66. (66.7 (55. (66. (55 (66 (5 (6

Resumen Introducción: en pacientes con enfermedades reumatológicas autoinmunes se recomienda la aplicación sistemática y secuencial de una serie de vacunas para la prevención de enfermedades transmisibles. El objetivo de este estudio fue estimar la proporción de pacientes con esclerosis sistémica (ES) que recibieron vacunación contra el coronavirus (SARS-CoV-2). Materiales y métodos: se envió una encuesta anónima por correo electrónico o contacto por WhatsApp desde mayo a septiembre de 2021, con preguntas para evaluar la adherencia al esquema de vacunación recomendado en pacientes con enfermedades reumatológicas, así como temores, preferencias y adherencia al esquema de vacunación contra el SARS-CoV-2. Resultados: se incluyeron 295 pacientes con ES. El 68,81% estaba vacunado contra el SARS-CoV-2 con al menos una dosis, de los cuales el 48,7% tenía dos dosis. El 84,75% refirió conversar con su médico sobre su esquema de vacunación general. Solo el 5,4% tenía las cuatro vacunas. El 93,56% manifestó voluntad de vacunarse contra el SARS-CoV-2; el 56,27% prefirió la vacuna Sputnik V. El 7,46% manifestó su voluntad de no vacunarse. Los factores que influyeron en la adherencia a la vacunación, con mayor frecuencia, fueron el miedo a contraer la infección por SARS-CoV-2 (86,1%) y las reacciones adversas (23,05%). Conclusiones: destacamos el hecho de que solo 6 meses después de que se dispusiera la vacunación contra el SARS-CoV-2, la mitad de los pacientes con ES tenía el esquema recomendado completo.

Abstract Introduction: in patients with autoimmune rheumatic diseases, the systematic and sequential application of a series of vaccines is recommended for the prevention of communicable diseases. The objective was to estimate the proportion of patients with systemic sclerosis (SSc) who received vaccination against coronavirus (SARS-CoV-2). Materials and methods: since may to september 2021, an anonymous survey was sent by email or messaging app, containing questions to assess adherence to the recommended vaccination schedule in patients with rheumatic diseases, as well as fears, preferences and adherence to vaccination schedule against SARS-CoV-2. Results: 295 patients with SSc were included. 68.81% were vaccinated for SARS-CoV-2 with at least one dose, 48.7% of this group had two doses. 84.75% reported talking to their doctor about their general vaccination schedule. Only 5.4% had all four vaccines. 93.56% expressed willingness to be vaccinated against SARS-CoV-2, 56.27% preferred the Sputnik V vaccine. 7.46% expressed their willingness to not be vaccinated. The factors that most frequently influenced adherence to vaccination were fear of contracting SARS-CoV-2 infection (86.1%) and adverse reactions (23.05%). Conclusions: we highlight the fact that only 6 months after vaccination against SARS-CoV-2 became available, half of the patients with SSc had the full recommended schedule.