RESUMO A permanencia de material obturador após o retratamento pode abrigar bactérias e tecidos orgánicos que podem influenciar o resultado da terapia. Objetivo O objetivo deste estudo foi avaliar, por micro-CT, a quantidade de material obturador remanescente no canal radicular após a desobturagdo com WaveOne Gold e ProDesign RT. Material e Método Quarenta caninos inferiores humanos foram instrumentados com o sistema ProTaper Next até o instrumento X2 (25.06) e obturados com cones de guta-percha e AHPlus. Os dentes foram divididos em dois grupos (n=20): WaveOne Gold 25.07 (WOG) e ProDesign RT 25.08 (PRT) e escaneados em micro-CT para quantificagdo do volume de material obturador remanescente. Os dados foram submetidos á transformando log10, o teste t de Student foi realizado para contabilizar múltiplas observagoes por amostra, a significáncia foi fixada em 5%. Resultados O teste t de Student mostrou que ndo houve diferenga no volume de material obturador remanescente entre os dois sistemas nos tergos: apical (p = 0,392), médio (p = 0,065) ou cervical (p = 0,918). Conclusao O material obturador remanescente estavapresente em todos os grupos e ambos os sistemas foram semelhantes na remogdo do material obturador radicular nos caninos inferiores.

ABSTRACT The remaining filling material after retreatment can harbor bacteria and organic tissues that can influence the outcome of the therapy. Aim The aim of this study was to evalúate, by micro-CT, the amount of filling material remaining in the root canal after its removal using WaveOne Gold or ProDesign RT. Material and Method Forty human mandibular canines were instrumented with the ProTaper Next system up to the X2 instrument (25.06) and filled with gutta-percha cones and AHPlus. Teeth were divided into 2 groups (n=20): WaveOne Gold 25.07 (WOG) and ProDesign RT 25.08 (PRT) for filling removal, after which they were scanned in a micro-CT device to quantify the volume of remaining filling material. The data were subjected to log 10 transformation, Student ’s t-test was performed to account for multiple observationsper sample, significance was set at 5%. Results Student ’s t-test showed that there was no difference between the two systems regarding the volume of remaining filling material in the thirds: apical (p = 0.392), middle (p = 0.065), or cervical (p = 0.918). Conclusión Remaining filling material was present in all groups and both systems were similar in removing root filling material in mandibular canines.

RESUMO 0 conhecimento da anatomia interna e suas variagoes anatómicas é fator importante para o adequado tratamento endodóntico. Portanto, é necessário investigar esses aspectos morfológicos entre diferentes grupos dentários de um mesmo paciente para definir o melhor protocolo para o caso. Objetivo Avaliar a morfologia e simetria de incisivos, pré-molares e molares inferiores homólogos por meio de tomografia computadorizada de feixe cónico (TCFC). Materiais e Método Foi realizada análise estatística descri-tiva para a frequéncia das variáveis categóricas e foi utilizado o teste do qui-quadrado ou teste exato de Fisher para testar a relagao entre sexo e lado em comparagao com número de raízes, número de canais e classificagao de Vertucci. Quarenta e cinco TCFC foram avaliadas e 444 dentes inferiores foram analisados. Foram considerados: o número de raízes, o número de canais, o tipo dos canais acordo com a classificagao de Vertucci e a presenga de relagao simétrica entre pares de dentes posteriores. Resultados Os resultados mostraram que 74% dos incisivos centrais inferiores tinham um canal radicular tipo 1 e 26% tinham dois canais; 73% dos incisivos laterais inferiores, 26%oeram do tipo I, tinham um canal e 27% tinham dois canais, com diferenga significativa no número de canais entre os grupos masculino e feminino (p < 0,05). Nos primeiros pré-molares inferiores, tipo I, um canal foi detectado em 70,5% e dois canais em 29,5%; nos segundos pré-molares inferiores, tipo I, um único canal foi detectado em 98,5%. O primeiro molar inferior foi observado com duas raízes em 98% e tres raízes em 2%o. O segundo molar inferior tinha duas raízes em 92,5% dos casos, uma raiz em 6% e tres raízes em 1,5%. A simetria foi maior nas mulheres em comparagao aos homens nos incisivos centrais. Conclusao Pode-se concluir que dentes de um mesmo grupo podem apresentar morfologias diferentes no mesmo paciente.

ABSTRACT Knowledge of root canal internal anatomy and its variations is important forproper endodontic treatment. It is therefore necessary to investigate morphological aspects among different dental groups in the same patient to define the best protocol for the case. Aim To evaluate the morphology and symmetry of homologous incisors, premolars and mandibular molars using cone beam computed tomography (CBCT). Materials and Method Descriptive statistical analysis was performed for the frequency of categorical variables, and a chi-square test or Fisher ’s exact test was used to test whether gender and side were associated with number of roots, number of canals, and Vertucci's classification. Forty-five CBCT scans were evaluated, and 444 mandibular teeth were analyzed. The number of roots, number of canals, classification of the canals in each root according to Vertucci and presence of a symmetrical relationship between pairs of posterior teeth were analyzed. Results The resuls showed that 74% of mandibular central incisors had type I root canal, 26% of mandibular lateral incisors had type I and, with a significant difference in the number of canals between males and females (p < 0.05). In mandibular first premolars, 70.5% had type I; and in mandibular second premolars, 98.5% had type I. Mandibular first molars had two roots in 98% of the cases. Second mandibular molars had two roots in 92.5% of the cases, one root in 6%, and three roots in 1.5%. Symmetry between central incisors was higher in females than in males. Conclusión Teeth of the same group can have different morphologies in the same patient.

Abstract Objective The present in vitro study incorporated niobium oxyhydroxide fillers into an experimental high-viscosity bulk-fill resin composite to improve its mechanical performance and provide it a bioactive potential. Methodology Scanning electron microscopy synthesized and characterized 0.5% niobium oxyhydroxide fillers, demonstrating a homogeneous morphology that represented a reinforcement for the feature. Fillers were weighed, gradually added to the experimental resin composite, and homogenized for one minute, forming three groups: BF (experimental high-viscosity bulk-fill resin composite; control), BF0.5 (experimental high-viscosity bulk-fill resin composite modified with 0.5% niobium oxyhydroxide fillers), and BFC (commercial bulk-fill resin composite Beautifil Bulk U, Shofu; positive control). In total, 10 specimens/groups (8 × 2 × 2 mm) underwent flexural strength (FS) tests in a universal testing machine (Instron) (500N). Resin composites were also assessed for Knoop hardness (KH), depth of cure (DoC), degree of conversion (DC), elastic modulus (E), and degree of color change (ΔE). The bioactive potential of the developed resin composite was evaluated after immersing the specimens into a simulated body fluid in vitro solution and assessing them using a Fourier-transformed infrared spectroscope with an attenuated total reflectance accessory. One-way ANOVA, followed by the Tukey’s test (p<0.05), determined FS, DC, KH, and ΔE. For DoC, ANOVA was performed, which demonstrated no significant difference between groups (p<0.05). Conclusions The high-viscosity bulk-fill resin composite with 0.5% niobium oxyhydroxide fillers showed promising outcomes as reinforcement agents and performed well for bioactive potential, although less predictable than the commercial resin composite with Giomer technology. highviscosity high viscosity bulkfill bulk fill 05 0 5 0.5 feature weighed minute control, control , control) BF05 BF0 BF0. fillers) U Shofu control. . 1 specimensgroups 8 ( mm FS (FS Instron (Instron 500N. 500N N (500N) KH (KH) DoC (DoC) DC (DC) E, E (E) ΔE (ΔE) Fouriertransformed Fourier transformed accessory Oneway One way Tukeys Tukey s p<0.05, p005 p p<0.05 (p<0.05) p<0.05. technology 0. (500N (KH (DoC (DC (E (ΔE p00 p<0.0 (p<0.05 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

Abstract During studies on fish parasites, two new species of Anacanthorus were found parasitizing serrasalmid fishes, Anacanthorus simpliciphallus sp. n. from the hybrid Piaractus mesopotamicus x Piaractus brachypomus and Anacanthorus brandtii sp. n. from Serrasalmus brandtii. Anacanthorus simpliciphallus sp. n. resembles Anacanthorus reginae in the morphology of the male copulatory organ (MCO) and accessory piece but differs from A. reginae in terms of the smaller size of the accessory piece, which corresponds approximately half the size of the MCO and by the presence of a conspicuous metraterm, with a membranous terminal region. Anacanthorus brandtii sp. n. differs from Anacanthorus scapanus by the expansion of the accessory piece, from Anacanthorus jegui by the ratio MCO (male copulatory organ) /AP (accessory piece) and by the expansion of hook shank, from Anacanthorus sciponophallus and A. reginae by the ratio MCO/AP. Anacanthorus brandtii sp. n. can be distinguished from A. reginae and A. simpliciphallus sp.n. by the size of hooks which is similar in A. reginae and A. simpliciphallus sp. n. and dissimilar in A. brandtii sp. n. The two new species also differ from each other by the expansion of shank. parasites fishes sp n (MCO A metraterm region AP shank MCOAP MCO/AP spn sp.n

Resumo Durante estudos em parasitos de peixes, duas novas espécies de Anacanthorus foram encontradas parasitando peixes serrasalmideos, Anacanthorus simpliciphallus sp. n. do híbrido Piaractus mesopotamicus x Piaractus brachypomus e Anacanthorus brandtii sp. n. de Serrasalmus brandtii. Anacanthorus simpliciphallus sp. n. assemelha-se a Anacanthorus reginae na morfologia do órgão copulatório masculino (OCM) e peça acessória (PA), mas difere de A. reginae pelo tamanho menor da peça acessória, que corresponde a aproximadamente metade do tamanho do OCM e pela presença de um metraterma conspícuo, com uma região terminal membranosa. Anacanthorus brandtii sp. n. difere de Anacanthorus scapanus pela expansão da peça acessória, de Anacanthorus jegui pela proporção OCM / PA e pela expansão da haste do gancho, e de Anacanthorus sciponophallus e A. reginae pela proporção OCM / PA. Anacanthorus brandtii sp. n. pode ser distinguido de A. reginae e A. simpliciphallus sp. n. pelo tamanho dos ganchos que é similar em A. reginae e A. simpliciphallus sp. n. e dissimilar em A. brandtii sp. n. As duas espécies novas também diferem entre si pela expansão da haste do gancho. serrasalmideos sp n assemelhase assemelha se (OCM PA, , (PA) A conspícuo membranosa gancho (PA

ABSTRACT: The regional lymphatic connections of the mammary glands in canines are poorly investigated, both in healthy animals and in those with mammary neoplasms. The objective was to establish the occurrence of metastases in the medial iliac lymph nodes (MILN) in bitches with mammary neoplasm, in addition to evaluating the effectiveness of the technique of lymphatic labeling of the MILN, administering methylene blue (MB) dye intrauterinely or intradermally. Thirty-two bitches with tumors in different mammary glands were included in the study. In 13 bitches (GU group), the MILNs were stained with intrauterine MB, followed by unilateral lymphadenectomy, ovariohysterectomy (OVH) and unilateral mastectomy. Nineteen bitches (GI group) underwent OVH, followed by MILN staining with intradermal MB, lymphadenectomy, and unilateral mastectomy. In GU, 11 bitches (84.62%) exhibited MB-stained MILNs, but staining was not observed in two (15.38%). Metastasis to MILNs was observed in three bitches (9.38%) from the GI and two (6.25%) from the GU. Intrauterine and intradermal staining of MILNs in bitches with mammary tumors was efficient, but intradermal administration of MB produced better results. Given metastatic spread to MILNs in approximately 15.63% of patients, we recommend that screening for MILNs should be considered as part of the staging of animals with malignant mammary neoplasms. ABSTRACT investigated neoplasms (MILN neoplasm (MB intradermally Thirtytwo Thirty study 1 GU group, group , lymphadenectomy OVH (OVH mastectomy 84.62% 8462 84 62 (84.62% MBstained 15.38%. 1538 15.38% . 15 38 (15.38%) 9.38% 938 9 (9.38% 6.25% 625 6 25 (6.25% efficient results 1563 63 15.63 patients 84.62 846 8 (84.62 153 15.38 3 (15.38% 9.38 93 (9.38 6.25 2 (6.25 156 15.6 84.6 (84.6 15.3 (15.38 9.3 (9.3 6.2 (6.2 15. 84. (84. (15.3 9. (9. 6. (6. (84 (15. (9 (6 (8 (15 ( (1

RESUMO: As conexões linfáticas regionais das glândulas mamárias em caninos são pouco investigadas, tanto em animais sadios quanto naqueles com neoplasmas mamários. Objetivou-se estabelecer à ocorrência de metástases nos linfonodos ilíacos mediais (MILN) em cadelas com neoplasma mamário, além de avaliar a eficácia da técnica de marcação linfática dos MILN, administrando o corante azul de metileno (MB) por via intrauterina ou intradérmica. Trinta e duas cadelas com neoplasmas malignos em diferentes glândulas mamárias foram incluídas no estudo. Em 13 cadelas (grupo GU), os MILNs foram corados com MB intrauterino, seguido de linfadenectomia unilateral, ovariohisterectomia (OVH) e mastectomia unilateral. Dezenove cães (grupo GI) foram submetidos a OVH, seguido de coloração MILN com MB intradérmico, linfadenectomia e mastectomia unilateral. No GU, 11 cães (84,62%) exibiram MILNs corados com MB, mas a coloração não foi observada em dois (15,38%). Metástases para MILNs foi observada em três cães (9,38%) do GI e em dois do GU (6,25%). A coloração intrauterina e intradérmica de MILNs em cadelas com tumores mamários foi eficiente, mas a administração intradérmica de MB produziu melhores resultados, observando a coloração de 100% dos linfonodos no GI e 84,62% no GU. Dada a disseminação metastática para MILNs em aproximadamente 15,63% dos pacientes, recomendamos que a investigação dos MILNs deve ser considerada como parte do estadiamento de animais com neoplasmas mamários malignos. RESUMO investigadas Objetivouse Objetivou se (MILN mamário (MB estudo 1 grupo , GU) intrauterino unilateral OVH (OVH intradérmico 8462 84 62 (84,62% 15,38%. 1538 15,38% . 15 38 (15,38%) 9,38% 938 9 (9,38% 6,25%. 625 6,25% 6 25 (6,25%) eficiente resultados 100 84,62 1563 63 15,63 pacientes 846 8 (84,62 153 15,38 3 (15,38% 9,38 93 (9,38 6,25 2 (6,25% 10 84,6 156 15,6 (84,6 15,3 (15,38 9,3 (9,3 6,2 (6,25 84, 15, (84, (15,3 9, (9, 6, (6,2 (84 (15, (9 (6, (8 (15 ( (6 (1

ABSTRACT Objective: To analyze the trend and spatial pattern of intimate partner rape reports against women in Northeast Brazil. Methods: Ecological time-series study and spatial analysis with secondary data from the Notifiable Diseases Information System between 2013 and 2022. Gross rape rates were calculated by type of intimate partner and by age group of the victim. Prais-Winsten regression was used to calculate the trend, and the global and local Moran indices were used for spatial analysis. Results: A total of 5,542 cases of intimate partner rape were reported. Spousal rates ranged from 0.34/100,000 women in 2013 to 0.51/100,000 in 2017, with greater increases between 2018 (1.04/100 thousand) and 2022 (1.28/100 thousand). There was an upward trend in the Northeast as a whole (APC=19.47; 95%CI 15.88–23.22) and in almost all states, except Paraíba and Sergipe. Cases perpetrated by boyfriends (APC=23.90; 95%CI 12.80–36.09) and among women aged 15 to 19 years (APC=22.63; 95%CI 4.18–44.35) showed the highest annual variation. A concentration of high rates was observed in several municipalities in the northwest of Ceará and southeast of Pernambuco. Conclusion: The trend in intimate partner rape rates against women increased in the Northeast, especially among younger women and by boyfriends, with a greater agglomeration of notifications in Ceará and Pernambuco.

RESUMO Objetivo: Analisar a tendência e o padrão espacial das notificações de estupro por parceiro íntimo contra mulheres no Nordeste do Brasil. Métodos: Estudo ecológico de série temporal e análise espacial com dados secundários do Sistema de Informação de Agravos de Notificação (SINAN) entre 2013 e 2022. Foram calculadas taxas brutas de estupro por tipo de parceiro íntimo e por faixa etária da vítima. Para o cálculo de tendência, utilizou-se a regressão de Prais-Winsten e, para a análise espacial, adotou-se o índice global e local de Moran. Resultados: Foram notificados 5.542 casos de estupro pelo parceiro íntimo. As taxas perpetradas pelo cônjuge variaram de 0,34/100 mil mulheres em 2013 para 0,51/100 mil em 2017, com maiores elevações entre 2018 (1,04/100 mil) e 2022 (1,28/100 mil). Houve tendência de aumento no Nordeste como um todo (VPA=19,47; IC95% 15,88–23,22) e em quase todos os estados, exceto Paraíba e Sergipe. Os casos perpetrados por namorados (VPA=23,90; IC95% 12,80–36,09) e entre mulheres de 15 a 19 anos (VPA=22,63; IC95% 4,18–44,35) exibiram maior variação anual. Observou-se concentração de altas taxas em diversos municípios no noroeste do Ceará e no sudeste de Pernambuco. Conclusão: A tendência das taxas de estupro contra mulheres perpetrado pelo parceiro íntimo aumentou no Nordeste, principalmente entre as mais jovens e por namorados, tendo maior aglomerado de notificações no Ceará e em Pernambuco.

ABSTRACT Objective: To analyze the trend and spatial pattern of intimate partner rape reports against women in Northeast Brazil. Methods: Ecological time-series study and spatial analysis with secondary data from the Notifiable Diseases Information System between 2013 and 2022. Gross rape rates were calculated by type of intimate partner and by age group of the victim. Prais-Winsten regression was used to calculate the trend, and the global and local Moran indices were used for spatial analysis. Results: A total of 5,542 cases of intimate partner rape were reported. Spousal rates ranged from 0.34/100,000 women in 2013 to 0.51/100,000 in 2017, with greater increases between 2018 (1.04/100 thousand) and 2022 (1.28/100 thousand). There was an upward trend in the Northeast as a whole (APC=19.47; 95%CI 15.88–23.22) and in almost all states, except Paraíba and Sergipe. Cases perpetrated by boyfriends (APC=23.90; 95%CI 12.80–36.09) and among women aged 15 to 19 years (APC=22.63; 95%CI 4.18–44.35) showed the highest annual variation. A concentration of high rates was observed in several municipalities in the northwest of Ceará and southeast of Pernambuco. Conclusion: The trend in intimate partner rape rates against women increased in the Northeast, especially among younger women and by boyfriends, with a greater agglomeration of notifications in Ceará and Pernambuco. Objective Brazil Methods timeseries time series 201 victim PraisWinsten Prais Winsten Results 5542 5 542 5,54 reported 034100000 0 34 100 000 0.34/100,00 051100000 51 0.51/100,00 2017 1.04/100 104100 1 04 (1.04/10 thousand 202 1.28/100 128100 28 (1.28/10 thousand. . APC=19.47 APC1947 APC 47 (APC=19.47 95CI CI 95 15.88–23.22 15882322 88 23 22 states Sergipe APC=23.90 APC2390 90 (APC=23.90 12.80–36.09 12803609 12 80 36 09 APC=22.63 APC2263 63 (APC=22.63 4.18–44.35 4184435 4 18 44 35 variation Pernambuco Conclusion 20 554 54 5,5 03410000 3 10 00 0.34/100,0 05110000 0.51/100,0 1.04/10 10410 (1.04/1 1.28/10 12810 2 (1.28/1 APC=19.4 APC194 (APC=19.4 9 15.88–23.2 1588232 8 APC=23.9 APC239 (APC=23.9 12.80–36.0 1280360 APC=22.6 APC226 6 (APC=22.6 4.18–44.3 418443 55 5, 0341000 0.34/100, 0511000 0.51/100, 1.04/1 1041 (1.04/ 1.28/1 1281 (1.28/ APC=19. APC19 (APC=19. 15.88–23. 158823 APC=23. APC23 (APC=23. 12.80–36. 128036 APC=22. APC22 (APC=22. 4.18–44. 41844 034100 0.34/100 051100 0.51/100 1.04/ 104 (1.04 1.28/ 128 (1.28 APC=19 APC1 (APC=19 15.88–23 15882 APC=23 APC2 (APC=23 12.80–36 12803 APC=22 (APC=22 4.18–44 4184 03410 0.34/10 05110 0.51/10 1.04 (1.0 1.28 (1.2 APC=1 (APC=1 15.88–2 1588 APC=2 (APC=2 12.80–3 1280 4.18–4 418 0341 0.34/1 0511 0.51/1 1.0 (1. 1.2 APC= (APC= 15.88– 158 12.80– 4.18– 41 034 0.34/ 051 0.51/ 1. (1 (APC 15.88 12.80 4.18 03 0.34 05 0.51 ( 15.8 12.8 4.1 0.3 0.5 15. 12. 4. 0.

RESUMO Objetivo: Analisar a tendência e o padrão espacial das notificações de estupro por parceiro íntimo contra mulheres no Nordeste do Brasil. Métodos: Estudo ecológico de série temporal e análise espacial com dados secundários do Sistema de Informação de Agravos de Notificação (SINAN) entre 2013 e 2022. Foram calculadas taxas brutas de estupro por tipo de parceiro íntimo e por faixa etária da vítima. Para o cálculo de tendência, utilizou-se a regressão de Prais-Winsten e, para a análise espacial, adotou-se o índice global e local de Moran. Resultados: Foram notificados 5.542 casos de estupro pelo parceiro íntimo. As taxas perpetradas pelo cônjuge variaram de 0,34/100 mil mulheres em 2013 para 0,51/100 mil em 2017, com maiores elevações entre 2018 (1,04/100 mil) e 2022 (1,28/100 mil). Houve tendência de aumento no Nordeste como um todo (VPA=19,47; IC95% 15,88–23,22) e em quase todos os estados, exceto Paraíba e Sergipe. Os casos perpetrados por namorados (VPA=23,90; IC95% 12,80–36,09) e entre mulheres de 15 a 19 anos (VPA=22,63; IC95% 4,18–44,35) exibiram maior variação anual. Observou-se concentração de altas taxas em diversos municípios no noroeste do Ceará e no sudeste de Pernambuco. Conclusão: A tendência das taxas de estupro contra mulheres perpetrado pelo parceiro íntimo aumentou no Nordeste, principalmente entre as mais jovens e por namorados, tendo maior aglomerado de notificações no Ceará e em Pernambuco. Objetivo Brasil Métodos SINAN (SINAN 201 vítima utilizouse utilizou se PraisWinsten Prais Winsten adotouse adotou Moran Resultados 5542 5 542 5.54 034100 0 34 100 0,34/10 051100 51 0,51/10 2017 1,04/100 104100 1 04 (1,04/10 202 1,28/100 128100 28 (1,28/10 mil. . VPA=19,47 VPA1947 VPA 47 (VPA=19,47 IC95 IC 15,88–23,22 15882322 88 23 22 estados Sergipe VPA=23,90 VPA2390 90 (VPA=23,90 12,80–36,09 12803609 12 80 36 09 VPA=22,63 VPA2263 63 (VPA=22,63 4,18–44,35 4184435 4 18 44 35 anual Observouse Observou Pernambuco Conclusão 20 554 54 5.5 03410 3 10 0,34/1 05110 0,51/1 1,04/10 10410 (1,04/1 1,28/10 12810 2 (1,28/1 VPA=19,4 VPA194 (VPA=19,4 IC9 15,88–23,2 1588232 8 VPA=23,9 VPA239 9 (VPA=23,9 12,80–36,0 1280360 VPA=22,6 VPA226 6 (VPA=22,6 4,18–44,3 418443 55 5. 0341 0,34/ 0511 0,51/ 1,04/1 1041 (1,04/ 1,28/1 1281 (1,28/ VPA=19, VPA19 (VPA=19, 15,88–23, 158823 VPA=23, VPA23 (VPA=23, 12,80–36, 128036 VPA=22, VPA22 (VPA=22, 4,18–44, 41844 034 0,34 051 0,51 1,04/ 104 (1,04 1,28/ 128 (1,28 VPA=19 VPA1 (VPA=19 15,88–23 15882 VPA=23 VPA2 (VPA=23 12,80–36 12803 VPA=22 (VPA=22 4,18–44 4184 03 0,3 05 0,5 1,04 (1,0 1,28 (1,2 VPA=1 (VPA=1 15,88–2 1588 VPA=2 (VPA=2 12,80–3 1280 4,18–4 418 0, 1,0 (1, 1,2 VPA= (VPA= 15,88– 158 12,80– 4,18– 41 1, (1 (VPA 15,88 12,80 4,18 ( 15,8 12,8 4,1 15, 12, 4,

RESUMO Objetivo: O objetivo do presente estudo é avaliar a ocorrência de defeitos dentinários na superfície apical após instrumentação rotatória em diferentes comprimentos de trabalho com o instrumento Trunatomy Prime, com ou sem o uso de lima glide path. Métodos: Vinte pré-molares inferiores humanos unirradiculares foram selecionados e divididos em 2 grupos experimentais (n=10). Grupo GTP (Glide Path + Trunatomy Prime), grupo TP (Trunatomy Prime). Resultados: Para verificar a concordância entre os examinadores, foi realizado o teste Kappa. Posteriormente, os resultados foram submetidos ao teste de normalidade de Shapiro-Wilk. A amostra apresentou comportamento anormal e foi submetida ao teste não paramétrico de Mann Whitney com nível de significância de 5%. Não foi encontrada diferença significativa entre os grupos. Conclusão: Conclui-se que não houve relação causal com a formação de defeitos dentinários com e sem o uso de instrumentos de glide path em diferentes limites de instrumentação com instrumentos do sistema Trunatomy. Objetivo Prime Métodos prémolares pré molares n=10. n10 n n=10 . 10 (n=10) Glide , Prime) Prime. Resultados examinadores Kappa Posteriormente ShapiroWilk. ShapiroWilk Shapiro Wilk. Wilk Shapiro-Wilk 5 5% Conclusão Concluise Conclui se n1 n=1 1 (n=10 n= (n=1 (n= (n

ABSTRACT Objective: The aim of the present study is to evaluate the occurrence of dentinal defects on the apical surface after rotary instrumentation at different working lengths with Trunatomy Prime system, with or without the use of a glide path file. Methods: Twenty human single-rooted mandibular premolars were selected and divided into 2 experimental groups (n=10). GTP group (Glide Path + Trunatomy Prime), the TP group (Trunatomy Prime). Results: To check the agreement between the examiners, the Kappa test was performed. Subsequently, the results were subjected to the Shapiro-Wilk normality test. The sample showed abnormal behavior and were subjected to the non-parametric Mann Whitney test with a significance level of 5%. No significant difference was found between the groups. Conclusion: It is concluded that there was no causal relationship with the formation of dentin defects with and without the use of glide path files at different limits of instrumentation with Trunatomy files. Objective system file Methods singlerooted single rooted n=10. n10 n n=10 . 10 (n=10) Glide Prime, , Prime) Prime. Results examiners performed Subsequently ShapiroWilk Shapiro Wilk nonparametric non parametric 5 5% Conclusion n1 n=1 1 (n=10 n= (n=1 (n= (n

ABSTRACT BACKGROUND: The risk of death due to tuberculosis (TB) in Brazil is high and strongly related to living conditions (LC). However, epidemiological studies investigating changes in LC and their impact on TB are lacking. OBJECTIVES: To evaluate the impact of LC on TB mortality in Brazil. DESIGN AND SETTING: This ecological study, using panel data on spatial and temporal aggregates, was conducted in 1,614 municipalities between 2002 and 2015. METHODS: Data were collected from the Mortality Information System and the Brazilian Institute of Geography and Statistics. The proxy variable used for LC was the Urban Health Index (UHI). Negative binomial regression models were used to estimate the effect of the UHI on TB mortality rate. Attributable risk (AR) was used as an impact measure. RESULTS: From 2002 to 2015, TB mortality rate decreased by 23.5%, and LC improved. The continuous model analysis resulted in an RR = 0.89 (95%CI = 0.82–0.96), so the AR was −12.3%. The categorized model showed an effect of 0.92 (95%CI = 0.83–0.95) in municipalities with intermediate LC and of 0.83 (95%CI = 0.82–0.91) in those with low LC, representing an AR for TB mortality of −8.7% and −20.5%, respectively. CONCLUSIONS: Improved LC impacted TB mortality, even when adjusted for other determinants. This impact was greater in the strata of low-LC municipalities. BACKGROUND (TB LC. . (LC) However lacking OBJECTIVES SETTING study aggregates 1614 1 614 1,61 200 2015 METHODS Statistics UHI. (UHI) (AR measure RESULTS 235 23 5 23.5% improved 089 0 89 0.8 95%CI 95CI CI 95 0.82–0.96, 082096 0.82–0.96 , 82 96 0.82–0.96) 123 12 3 −12.3% 092 92 0.9 0.83–0.95 083095 83 083 0.82–0.91 082091 91 87 8 7 −8.7 205 20 −20.5% respectively CONCLUSIONS determinants lowLC (LC 161 61 1,6 201 (UHI 2 23.5 08 0. 9 08209 0.82–0.9 −12.3 09 0.83–0.9 08309 −8. −20.5 16 6 1, 23. 0820 0.82–0. −12. 0.83–0. 0830 −8 −20. 082 0.82–0 −12 0.83–0 − −20 0.82– −1 0.83– −2 0.82

ABSTRACT. Rich in oil and protein, canola is a significantly promising crop and is widely explored as an alternative to grain cultivation in the winter period. Recently, canola oil has been largely consumed due to a variety of health benefits and low production costs. Nonetheless, impasses such as determining the correct sowing date and optimizing harvesting methods make it difficult to expand cultivation. Accordingly, the purpose of the study was to evaluate the performance of two canola hybrids on three sowing dates and distinct harvesting procedures. The study was conducted in Cachoeira do Sul, Rio Grande do Sul, Brazil, on three sowing dates (2019, 2020, and 2021), with two hybrids (Hyola 433 and Hyola 575 CL). The methods of direct harvesting, direct harvesting with the application of adjuvant, cut-row, and cut-row with the application of adjuvant were evaluated. The main yield components were determined, in addition to biochemical parameters, such as oil and protein content and determination of oil quality (acid, peroxide, iodine, extinction, and saponification indices). Appropriately, this study indicated that canola is significantly sensitive to climatic conditions, mainly to temperature and sowing time, reducing grain and biomass yield in late sowing and resulting in serious harvest losses. Oil and grain protein contents were affected by climatic conditions. Nevertheless, the protein content was not affected by late sowing. Canola oil presented significant chemical conditions, with a correlation between the crops with higher oil yield and better oil quality. ABSTRACT period Recently costs Nonetheless Accordingly procedures Sul Brazil 2019, 2019 (2019 2020 2021, 2021 , 2021) 43 57 CL. CL . CL) cutrow, cutrow cut row, row evaluated determined parameters acid, acid (acid peroxide iodine extinction indices. indices indices) Appropriately conditions time losses Nevertheless 201 (201 202 4 5 20 (20 2 (2 (

Objetivo: verificar a validade clínica da proposição de um novo diagnóstico de enfermagem denominado sede perioperatória, com base na acurácia diagnóstica de seus indicadores clínicos, incluindo a magnitude de efeito de seus fatores etiológicos. Método: estudo de validação clínica diagnóstica com 150 pacientes cirúrgicos em um hospital universitário. Foram coletadas variáveis sociodemográficas e indicadores clínicos relacionados à sede. Empregou-se a técnica de análise de classe latente. Resultados: dois modelos de classes latentes foram propostos para as características definidoras. O modelo ajustado no pré-operatório incluiu: lábios ressecados, saliva grossa, língua grossa, vontade de beber água, relato do cuidador, garganta seca e constante deglutição de saliva. No pós-operatório: garganta seca, saliva grossa, língua grossa, constante deglutição de saliva, vontade de beber água, gosto ruim na boca. Os fatores relacionados Temperatura do ambiente elevada e Boca seca estão associados à presença de sede, assim como as condições associadas Utilização de anticolinérgicos e Intubação. A prevalência de sede foi de 62,6% no pré-operatório e 50,2% no pós-operatório imediato. Conclusão: a proposição diagnóstica de sede perioperatória apresentou bons parâmetros de acurácia de seus indicadores clínicos e efeitos etiológicos. Essa proposição em uma taxonomia de enfermagem permitirá maior visibilidade, valorização e tratamento desse sintoma. Objetivo etiológicos Método 15 universitário Empregouse Empregou se latente Resultados definidoras préoperatório pré operatório incluiu ressecados grossa água cuidador pósoperatório pós boca Intubação 626 62 6 62,6 502 50 2 50,2 imediato Conclusão visibilidade sintoma 1 62, 5 50,

Objective: to verify the clinical validity of the proposition of a new nursing diagnosis called perioperative thirst, based on the diagnostic accuracy of its clinical indicators, including the magnitude of effect of its etiological factors. Method: clinical diagnostic validation study with a total of 150 surgical patients at a university hospital. Sociodemographic variables and clinical indicators related to thirst were collected. The latent class analysis technique was used. Results: two models of latent classes were proposed for the defining characteristics. The model adjusted preoperatively included: dry lips, thick saliva, thick tongue, desire to drink water, caregiver report, dry throat and constant swallowing of saliva. In the postoperative period: dry throat, thick saliva, thick tongue, constant swallowing of saliva, desire to drink water, bad taste in the mouth. The factors related to “high ambient temperature” and “dry mouth” are associated with the presence of thirst, as well as the associated conditions “use of anticholinergics” and “intubation”. The prevalence of thirst was 62.6% in the pre and 50.2% in the immediate postoperative period. Conclusion: the diagnostic proposition of perioperative thirst showed good accuracy parameters for its clinical indicators and etiological effects. This proposition in a nursing taxonomy will allow greater visibility, appreciation and treatment of this symptom. Objective Method 15 hospital collected used Results characteristics included lips saliva tongue water report period mouth high temperature use anticholinergics intubation. intubation . “intubation” 626 62 6 62.6 502 50 2 50.2 Conclusion effects visibility symptom 1 “intubation 62. 5 50.

Objetivo: verificar la validez clínica de la proposición de un nuevo diagnóstico de enfermería denominado sed perioperatoria, basado en la precisión diagnóstica de sus indicadores clínicos, incluyendo la magnitud del efecto de sus factores etiológicos. Método: estudio de validación clínica diagnóstica con 150 pacientes quirúrgicos en un hospital universitario. Se recogieron variables sociodemográficas e indicadores clínicos relacionados con la sed. Se utilizó la técnica de análisis de clases latentes. Resultados: se propusieron dos modelos de clases latentes para las características definitorias. El modelo ajustado en el preoperatorio incluía: labios resecos, saliva espesa, lengua espesa, ganas de beber agua, informe del cuidador, garganta seca y deglución constante de saliva. En el postoperatorio: sequedad de garganta, saliva espesa, lengua espesa, constante deglución de saliva, ganas de beber agua, mal gusto en la boca. Los factores relacionados “temperatura ambiente elevada” y “sequedad de boca” se asocian a la presencia de sed, así como las condiciones asociadas “uso de anticolinérgicos” e “intubación”. La prevalencia de sed fue del 62,6% en el preoperatorio y del 50,2% en el postoperatorio inmediato. Conclusión: la proposición diagnóstica de la sed perioperatoria mostró buenos parámetros de precisión de sus indicadores clínicos y efectos etiológicos. Esta propuesta en una taxonomía de enfermería permitirá una mayor visibilidad, apreciación y tratamiento de este síntoma. Objetivo etiológicos Método 15 universitario Resultados definitorias incluía resecos espesa agua cuidador boca temperatura elevada uso anticolinérgicos intubación. intubación . “intubación” 626 62 6 62,6 502 50 2 50,2 inmediato Conclusión visibilidad síntoma 1 “intubación 62, 5 50,

ABSTRACT Objective: To assess the effect of atelectasis during mechanical ventilation on the periatelectatic and normal lung regions in a model of atelectasis in rats with acute lung injury induced by lipopolysaccharide. Methods: Twenty-four rats were randomized into the following four groups, each with 6 animals: the Saline-Control Group, Lipopolysaccharide Control Group, Saline-Atelectasis Group, and Lipopolysaccharide Atelectasis Group. Acute lung injury was induced by intraperitoneal injection of lipopolysaccharide. After 24 hours, atelectasis was induced by bronchial blocking. The animals underwent mechanical ventilation for two hours with protective parameters, and respiratory mechanics were monitored during this period. Thereafter, histologic analyses of two regions of interest, periatelectatic areas and the normally-aerated lung contralateral to the atelectatic areas, were performed. Results: The lung injury score was significantly higher in the Lipopolysaccharide Control Group (0.41 ± 0.13) than in the Saline Control Group (0.15 ± 0.51), p < 0.05. Periatelectatic regions showed higher lung injury scores than normally-aerated regions in both the Saline-Atelectasis (0.44 ± 0.06 x 0.27 ± 0.74 p < 0.05) and Lipopolysaccharide Atelectasis (0.56 ± 0.09 x 0.35 ± 0.04 p < 0.05) Groups. The lung injury score in the periatelectatic regions was higher in the Lipopolysaccharide Atelectasis Group (0.56 ± 0.09) than in the periatelectatic region of the Saline-Atelectasis Group (0.44 ± 0.06), p < 0.05. Conclusion: Atelectasis may cause injury to the surrounding tissue after a period of mechanical ventilation with protective parameters. Its effect was more significant in previously injured lungs. Objective lipopolysaccharide Methods Twentyfour Twenty groups SalineControl SalineAtelectasis 2 blocking parameters Thereafter interest normallyaerated normally aerated performed Results 0.41 041 0 41 (0.4 0.13 013 13 0.15 015 15 (0.1 0.51, 051 0.51 , 51 0.51) 005 05 0.05 0.44 044 44 006 06 0.0 027 27 0.2 074 74 0.7 0.56 056 56 (0.5 009 09 035 35 0.3 004 04 Groups 0.06, 0.06) Conclusion lungs 0.4 4 (0. 0.1 01 1 0.5 5 00 0. 02 07 7 03 3 (0 (

RESUMO Objetivo: Avaliar o efeito da atelectasia durante a ventilação mecânica nas regiões periatelectáticas e pulmonares normais em um modelo de atelectasia em ratos com lesão pulmonar aguda induzida por lipopolissacarídeo. Métodos: Foram distribuídos aleatoriamente 24 ratos em quatro grupos, cada um com 6 animais: Grupo Salina-Controle, Grupo Lipopolissacarídeo-Controle, Grupo Salina-Atelectasia e Grupo Lipopolissacarídeo-Atelectasia. A lesão pulmonar aguda foi induzida por injeção intraperitoneal de lipopolissacarídeo. Após 24 horas, a atelectasia foi induzida por bloqueio brônquico. Os animais foram submetidos à ventilação mecânica por 2 horas com parâmetros ventilatórios protetores, e a mecânica respiratória foi monitorada durante esse período. Em seguida, foram realizadas análises histológicas de duas regiões de interesse: as áreas periatelectásicas e o pulmão normalmente aerado contralateral às áreas atelectásicas. Resultados: O escore de lesão pulmonar foi significativamente maior no Grupo Controle-Lipopolissacarídeo (0,41 ± 0,13) do que no Grupo Controle-Solução Salina (0,15 ± 0,51), com p < 0,05. As regiões periatelectásicas apresentaram escores maiores de lesão pulmonar do que as regiões normalmente aeradas nos Grupos Atelectasia-Solução Salina (0,44 ± 0,06 versus 0,27 ± 0,74, p < 0,05) e Atelectasia-Lipopolissacarídeo (0,56 ± 0,09 versus 0,35 ± 0,04, p < 0,05). O escore de lesão pulmonar nas regiões periatelectásicas foi maior no Grupo Atelectasia-Lipopolissacarídeo (0,56 ± 0,09) do que na região periatelectásica do Grupo Atelectasia-Solução Salina (0,44 ± 0,06), p < 0,05. Conclusão: A atelectasia pode causar lesão no tecido circundante após um período de ventilação mecânica com parâmetros ventilatórios protetores. Seu efeito foi mais significativo em pulmões previamente lesionados. Objetivo lipopolissacarídeo Métodos grupos SalinaControle, SalinaControle Controle, Controle Salina-Controle LipopolissacarídeoControle, LipopolissacarídeoControle Lipopolissacarídeo Lipopolissacarídeo-Controle SalinaAtelectasia Atelectasia LipopolissacarídeoAtelectasia. LipopolissacarídeoAtelectasia Atelectasia. Lipopolissacarídeo-Atelectasia brônquico protetores seguida interesse atelectásicas Resultados ControleLipopolissacarídeo 0,41 041 0 41 (0,4 0,13 013 13 ControleSolução Solução 0,15 015 15 (0,1 0,51, 051 0,51 , 51 0,51) 005 05 0,05 AtelectasiaSolução 0,44 044 44 006 06 0,0 027 27 0,2 074 74 0,74 AtelectasiaLipopolissacarídeo 0,56 056 56 (0,5 009 09 035 35 0,3 004 04 0,04 . 0,06, 0,06) Conclusão lesionados 0,4 4 (0, 0,1 01 1 0,5 5 00 0, 02 07 7 0,7 03 3 (0 (

Resumo Introdução: O cancro do cólon e reto é a neoplasia mais frequente considerando os dois géneros. . A deteção de lesões pré-malignas por colonoscopia está associada a uma redução da incidência e da mortalidade. Estudos sobre a utilização da luz de banda estreita (NBI) na deteção de lesões serreadas tiveram resultados promissores, mas heterogéneos. Métodos: Realizámos um ensaio clínico randomizado para comparar o número médio de lesões serreadas e lesões hiperplásicas ≥10 mm com NBI ou luz branca de alta-definição (HD-WL). Como resultados secundários comparámos a prevalência e as taxas de deteção de lesões serreadas sésseis, adenomas e todas as lesões. Resultados: Foram randomizados 782 doentes (392 no grupo HD-WL e 390 no grupo NBI). O número médio de lesões serreadas e hiperplásicas ≥10 mm não apresentou diferença estatisticamente significativa entre dois grupos (0.118 vs. 0.156, p = 0.44). A taxa de deteção de adenomas (55.2% vs. 53.2%, p = 0.58) e a taxa de deteção de lesões serreadas sésseis (6.8% vs. 7.5%, p = 0.502) também não foram diferentes. O tempo de retirada foi maior no grupo NBI (10.88 vs. 9.47 min, p = 0.004) e o tempo total de procedimento teve um ligeiro aumento não atingindo significância estatística (20.97 vs. 19.30 min, p = 0.052). Conclusão: A utilização da luz NBI por rotina não aumenta a deteção de lesões serreadas nem de qualquer lesão pré-maligna e aumenta o tempo de retirada na colo-noscopia.

Abstract Background: Colorectal cancer (CRC) is a leading cause of cancer. The detection of premalignant lesions by colonoscopy is associated with reduced CRC incidence and mortality. Narrow band imaging has shown promising but conflicting results for the detection of serrated lesions. Methods: We performed a randomized clinical trial to compare the mean detection of serrated lesions and hyperplastic polyps ≥10 mm with NBI or high-definition white light (HD-WL) withdrawal. We also compared all sessile serrated lesions (SSLs), adenoma, and polyp prevalence and rates. Results: Overall, 782 patients were randomized (WL group 392 patients; NBI group 390 patients). The average number of serrated lesions and hyperplastic polyps ≥10 mm detected per colonoscopy (primary endpoint) was similar between the HD-WL and NBI group (0.118 vs. 0.156, p = 0.44). Likewise, the adenoma detection rate (55.2% vs. 53.2%, p = 0.58) and SSL detection rate (6.8% vs. 7.5%, p = 0.502) were not different between the two study groups. Withdrawal time was higher in the NBI group (10.88 vs. 9.47 min, p = 0.004), with a statistically nonsignificant higher total procedure time (20.97 vs. 19.30 min, p = 0.052). Conclusions: The routine utilization of narrow band imaging does not improve the detection of serrated class lesions or any pre-malignant lesion and increases the with-drawal time.

Abstract This in vitro study synthesized hybrid nanofibers embedded in graphene oxide (GO) and incorporated them into experimental resin composite monomers to evaluate their physical-mechanical properties. Inorganic-organic hybrid nanofibers were produced with precursor solutions of 1% wt. GO-filled Poly (d,l-lactide, PLA) fibers and scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) characterized the morphology and chemical composition of the spun fibers. Resin composite monomers were developed and a total of 5% nanofibers were incorporated into the experimental materials. Three groups were developed: G1 (control resin monomers), G2 (resin monomers/PLA nanofibers), and G3 (resin monomers/inorganic-organic hybrid nanofibers). Contact angle (n=3), flexural strength (n=22), elastic modulus (n=22), and Knoop hardness (n=6) were evaluated. The mean of the three indentations was obtained for each sample. The normality of data was assessed by QQ Plot with simulated envelopes and analyzed by Welch's method (p<0.05). Overall, SEM images showed the regular shape of nanofibers but were non-aligned. Compositional analysis from EDS (n=6) revealed the presence of carbon and oxygen (present in GO composition) and Si from the functionalization process. The results of contact angle (°) and hardness (Kg/mm2) for each group were as follow, respectively: G1 (59.65±2.90; 37.48±1.86a), G2 (67.99±3.93; 50.56±1.03b) and G3 (62.52±7.40; 67.83±1.01c). The group G3 showed the highest Knoop hardness values (67.83 kg/mm2), and the flexural strength of all groups was adversely affected. The experimental resin composite composed of hybrid nanofibers with GO presented increased hardness values and hydrophilic behavior. (GO physicalmechanical physical mechanical properties Inorganicorganic Inorganic organic 1 wt GOfilled filled d,llactide, dllactide d,l lactide, d l lactide (d,l-lactide PLA (SEM energydispersive energy dispersive Xray X ray (EDS 5 materials G control monomers, , monomers) monomersPLA nanofibers, nanofibers) monomers/inorganicorganic monomersinorganicorganic monomers/inorganic inorganic nanofibers. . n=3, n3 n n=3 3 (n=3) n=22, n22 n=22 22 (n=22) n=6 n6 6 (n=6 evaluated sample Welchs Welch s p<0.05. p005 p p<0.05 0 05 (p<0.05) Overall nonaligned. nonaligned non aligned. aligned non-aligned present process ° (° Kg/mm2 Kgmm2 Kgmm Kg mm2 mm (Kg/mm2 follow respectively 59.65±2.90 5965290 59 65 2 90 (59.65±2.90 37.48±1.86a, 3748186a 37.48±1.86a 37 48 86a 37.48±1.86a) 67.99±3.93 6799393 67 99 93 (67.99±3.93 50.56±1.03b 5056103b b 50 56 03b 62.52±7.40 6252740 62 52 7 40 (62.52±7.40 67.83±1.01c. 6783101c c 67.83±1.01c 83 01c 67.83±1.01c) 67.83 6783 (67.8 kg/mm2, kgmm2 kgmm kg/mm2 kg kg/mm2) affected behavior llactide d,llactide dl inorganicorganic monomersinorganic n= (n=3 n2 n=2 (n=22 (n= p00 p<0.0 (p<0.05 ( Kg/mm (Kg/mm 59.65±2.9 596529 9 (59.65±2.9 4 67.99±3.9 679939 (67.99±3.9 62.52±7.4 625274 (62.52±7.4 8 67.8 678 (67. kg/mm (n=2 (n p0 p<0. (p<0.0 59.65±2. 59652 (59.65±2. 67.99±3. 67993 (67.99±3. 62.52±7. 62527 (62.52±7. 67. (67 p<0 (p<0. 59.65±2 5965 (59.65±2 67.99±3 6799 (67.99±3 62.52±7 6252 (62.52±7 (6 p< (p<0 59.65± 596 (59.65± 67.99± 679 (67.99± 62.52± 625 (62.52± (p< 59.65 (59.65 67.99 (67.99 62.52 (62.52 (p 59.6 (59.6 67.9 (67.9 62.5 (62.5 59. (59. 62. (62. (59 (62 (5

Resumo Este estudo in vitro sintetizou nanofibras híbridas embebidas em óxido de grafeno (GO), incorporando-as à uma resina composta experimental de monômeros para avaliar suas propriedades físico-mecânicas. Nanofibras híbridas inorgânica-orgânicas foram produzidas com soluções precursoras de fibras poli (d, l-lactídeo, PLA) preenchidas com GO a 1% em peso e microscopia eletrônica de varredura (MEV) e espectroscopia de raio-X de energia dispersiva (EDS) caracterizaram a morfologia e composição química das fibras. Monômeros de resina composta foram desenvolvidos e um total de 5% de nanofibras foi incorporado aos materiais experimentais. Três grupos foram desenvolvidos: G1 (monômeros de resina controle), G2 (monômeros de resina/ nanofibras de PLA) e G3 (monômeros de resina/nanofibras híbridas inorgânico-orgânicas). Ângulo de contato (n=3), resistência à flexão (n=22), módulo de elasticidade (n=22) e dureza Knoop (n=6) foram avaliados. A média das três endentações foi obtida para cada amostra. A normalidade dos dados foi avaliada pelo QQ Plot com envelopes simulados e analisada pelo método de Welch (p<0,05). No geral, as imagens de MEV mostraram forma regular de nanofibras, mas não alinhadas. A análise composicional de EDS (n=6) revelou a presença de carbono e oxigênio (presentes na composição do GO) e Si resultante do processo de funcionalização. Os resultados do ângulo de contato (°) e dureza (Kg/mm2) para cada grupo foram os seguintes, respectivamente: G1 (59,65±2,90; 37,48±1,86a), G2 (67,99±3,93; 50,56±1,03b) e G3 (62,52±7,40; 67,83±1,01c). G3 apresentou os maiores valores de dureza Knoop (67,83 kg/mm2), e a resistência à flexão de todos os grupos foi prejudicada. A resina composta experimental composta por nanofibras híbridas com GO apresentou maiores valores de dureza e comportamento hidrofílico. GO, , (GO) incorporandoas incorporando físicomecânicas. físicomecânicas físico mecânicas. mecânicas físico-mecânicas inorgânicaorgânicas inorgânica orgânicas d, d (d llactídeo, llactídeo l lactídeo, lactídeo l-lactídeo PLA 1 (MEV raioX raio X (EDS 5 experimentais G controle, controle controle) resinananofibras inorgânicoorgânicas. inorgânicoorgânicas inorgânico . inorgânico-orgânicas) n=3, n3 n n=3 3 (n=3) n=22, n22 n=22 22 (n=22 n=6 n6 6 (n=6 avaliados amostra p<0,05. p005 p p<0,05 0 05 (p<0,05) geral alinhadas presentes funcionalização ° (° Kg/mm2 Kgmm2 Kgmm Kg mm2 mm (Kg/mm2 seguintes respectivamente 59,65±2,90 5965290 59 65 2 90 (59,65±2,90 37,48±1,86a, 3748186a 37,48±1,86a 37 48 86a 37,48±1,86a) 67,99±3,93 6799393 67 99 93 (67,99±3,93 50,56±1,03b 5056103b b 50 56 03b 62,52±7,40 6252740 62 52 7 40 (62,52±7,40 67,83±1,01c. 6783101c c 67,83±1,01c 83 01c 67,83±1,01c) 67,83 6783 (67,8 kg/mm2, kgmm2 kgmm kg/mm2 kg kg/mm2) prejudicada hidrofílico (GO inorgânico-orgânicas n= (n=3 n2 n=2 (n=2 (n= p00 p<0,0 (p<0,05 ( Kg/mm (Kg/mm 59,65±2,9 596529 9 (59,65±2,9 4 67,99±3,9 679939 (67,99±3,9 62,52±7,4 625274 (62,52±7,4 8 67,8 678 (67, kg/mm (n p0 p<0, (p<0,0 59,65±2, 59652 (59,65±2, 67,99±3, 67993 (67,99±3, 62,52±7, 62527 (62,52±7, 67, (67 p<0 (p<0, 59,65±2 5965 (59,65±2 67,99±3 6799 (67,99±3 62,52±7 6252 (62,52±7 (6 p< (p<0 59,65± 596 (59,65± 67,99± 679 (67,99± 62,52± 625 (62,52± (p< 59,65 (59,65 67,99 (67,99 62,52 (62,52 (p 59,6 (59,6 67,9 (67,9 62,5 (62,5 59, (59, 62, (62, (59 (62 (5

Abstract Objective: This study monitors trends in access to cancer screening, focusing on mammography, Papanicolaou (Pap smear), and Prostate-Specific Antigen (PSA), assessing the magnitude of inequality in the city of São Paulo from 2003 to 2015 according to education level. Method: This is a cross-sectional population-based study conducted with data from the 2003, 2008, and 2015 editions of the Health Survey of the City of São Paulo (ISA-Capital). Outcome variables were the proportion of mammography, Papanicolaou (Pap smear), and Prostate-Specific Antigen (PSA) tests according to the protocols. Inequality was measured by education level according to years of study. For static analysis, Poisson regression was used to estimate proportion ratios. Results: The proportion of Pap smears remained stationary at a high level (>89%) throughout the study period, while access to mammography and PSA tests significantly increased in the 2003–2015 period. The present results indicate inequalities in access to cancer screening due to education, and being more expressive for mammography and PSA tests. However, this inequality significantly decreased over the period analyzed comparing the most educated individuals with those with the lowest educational level. In addition, an increase in the proportion of tests performed in the Brazilian Unified Health System was identified, especially for mammography and PSA tests, in the period 2003–2015. Conclusions: The inequalities observed in the access to preventive exams were influenced by the level of education. The offer of exams was expanded, more significantly for mammography and PSA, especially among the less educated group. Objective smear, smear , smear) ProstateSpecific Prostate Specific 200 201 Method crosssectional cross sectional populationbased population based 2008 ISACapital. ISACapital ISA Capital . (ISA-Capital) (PSA protocols analysis ratios Results >89% 89 (>89% 20032015 2003–201 However addition identified Conclusions expanded group 20 (ISA-Capital >89 8 (>89 2003201 2003–20 2 >8 (>8 200320 2003–2 > (> 20032 2003– (