ABSTRACT Cross-sectional study describing the characteristics of the morbidity from Extrapulmonary Tuberculosis (EPTB) in Brazil from 2010 to 2021. The percentages of EPTB in the following sites were evaluated: pleural, peripheral nodes, genitourinary, bone, ocular, miliary, meningoencephalic, cutaneous, laryngeal and others. Descriptive statistics summarized the socioepidemiological characteristics by region. The joinpoint regression model was used to analyse and graphically represent the trend. Pearson’s bivariate correlation and the Poisson regression model were used to estimate the relationship and effect of the variables on the cases. The pleura was the most affected site, as well as the Southeast region. Men, blacks, 15-59 years old group and HIV/AIDS were the most associated to EPTB. Incidence rates showed a decrease between 2019 and 2021 in the North, Midwest and South regions. In the country, the reduction in the trend predominated, except in children from 0 to 14 years old, with a significant increase in the female from 2019. This study provided socioepidemiological information on the occurrence of TBEP, highlighting the importance of the coverage and quality of the primary health care attentions teams.

RESUMEN Estúdio transversal caracterizando epidemiológica y sociodemográficamente la morbilidad por Tuberculosis Extrapulmonar (TBEP) en Brasil de 2010 a 2021. Se evaluaron los porcentajes de TBEP en los espacios: pleural, ganglios periféricos, genitourinario, óseo, ocular, miliar, meningoencefálico, cutáneo, laríngeo y otros. La estadística descriptiva resumió las características socioepidemiológicas por regiones. Se utilizó el modelo de regresión joinpoint para analizar y representar gráficamente la tendencia. Para estimar la relación y efecto de las variables sobre los casos se utilizó la correlación bivariada de Pearson y el modelo de regresión de Poisson. La pleura fue el ámbito más afectado, así como la región sudeste. Predominaron los hombres, negros, el grupo etario de 15 a 59 años y el VIH/SIDA como enfermedad más asociada a la TBEP. Las tasas de incidencia mostraron caída entre 2019 y 2021 en las regiones Norte, Centro-Oeste y Sur. En el país predominó el descenso de la tendencia, excepto en niños de 0 a 14 años, con aumento significativo del sexo femenino a partir de 2019. Este estudio proporcionó informaciones socioepidemiológicas sobre el acaecimiento de TBEP, destacando la importancia de verificar la cobertura y la calidad de la atención por parte de los equipos de salud de la familia.

ABSTRACT Cross-sectional study describing the characteristics of the morbidity from Extrapulmonary Tuberculosis (EPTB) in Brazil from 2010 to 2021. The percentages of EPTB in the following sites were evaluated: pleural, peripheral nodes, genitourinary, bone, ocular, miliary, meningoencephalic, cutaneous, laryngeal and others. Descriptive statistics summarized the socioepidemiological characteristics by region. The joinpoint regression model was used to analyse and graphically represent the trend. Pearson’s bivariate correlation and the Poisson regression model were used to estimate the relationship and effect of the variables on the cases. The pleura was the most affected site, as well as the Southeast region. Men, blacks, 15-59 years old group and HIV/AIDS were the most associated to EPTB. Incidence rates showed a decrease between 2019 and 2021 in the North, Midwest and South regions. In the country, the reduction in the trend predominated, except in children from 0 to 14 years old, with a significant increase in the female from 2019. This study provided socioepidemiological information on the occurrence of TBEP, highlighting the importance of the coverage and quality of the primary health care attentions teams. Crosssectional Cross sectional (EPTB 201 evaluated pleural nodes genitourinary bone ocular miliary meningoencephalic cutaneous others region Pearsons Pearson s cases site Men blacks 1559 15 59 15-5 HIVAIDS HIV AIDS 202 North regions country predominated 1 TBEP teams 20 155 5 15- 2

RESUMEN Estúdio transversal caracterizando epidemiológica y sociodemográficamente la morbilidad por Tuberculosis Extrapulmonar (TBEP) en Brasil de 2010 a 2021. Se evaluaron los porcentajes de TBEP en los espacios: pleural, ganglios periféricos, genitourinario, óseo, ocular, miliar, meningoencefálico, cutáneo, laríngeo y otros. La estadística descriptiva resumió las características socioepidemiológicas por regiones. Se utilizó el modelo de regresión joinpoint para analizar y representar gráficamente la tendencia. Para estimar la relación y efecto de las variables sobre los casos se utilizó la correlación bivariada de Pearson y el modelo de regresión de Poisson. La pleura fue el ámbito más afectado, así como la región sudeste. Predominaron los hombres, negros, el grupo etario de 15 a 59 años y el VIH/SIDA como enfermedad más asociada a la TBEP. Las tasas de incidencia mostraron caída entre 2019 y 2021 en las regiones Norte, Centro-Oeste y Sur. En el país predominó el descenso de la tendencia, excepto en niños de 0 a 14 años, con aumento significativo del sexo femenino a partir de 2019. Este estudio proporcionó informaciones socioepidemiológicas sobre el acaecimiento de TBEP, destacando la importancia de verificar la cobertura y la calidad de la atención por parte de los equipos de salud de la familia. (TBEP 201 espacios pleural periféricos genitourinario óseo ocular miliar meningoencefálico cutáneo otros tendencia Poisson afectado sudeste hombres negros 1 5 VIHSIDA VIH SIDA 202 Norte CentroOeste Centro Oeste Sur familia 20 2

ABSTRACT Endocochlear, retrocochlear and/or central origin hearing damage may be related to the absence of appropriate levels of thyroid hormone during morphogenesis and/or auditory system development. Hearing disorders related to the thyroid are not well studied, despite speculation on the pathophysiological mechanisms. The objective of this review was to characterize the main pathophysiological mechanisms of congenital hypothyroidism and to evaluate the relationship with central and peripheral hearing disorders. We conducted a literature review using the databases MedLine, LILACS, Cochrane Library, SciELO, Institute for Scientific Information (ISI), Embase, and Science Direct between July and September on 2016. We identified the studies that address hearing disorder mechanisms on the congenital hypothyroidism. Congenital hypothyroidism may have clinical and subclinical manifestations that affect the auditory system and may be a potential risk factor for hearing impairment. Hearing impairment can severely impact quality-of-life, which emphasizes the importance of monitoring and evaluating hearing during the clinical routine of these patients.

Aim: The objective of this study was to critically analyze data of the National Notification System for Adverse Events and Technical Complaints (Notivisa) related to central venous catheters, through an evaluation of the description of notifications recorded between 2006 and 2009. Methods: Notifications were categorized and evaluated to: (i) determine the number of adverse events and technical complaints, (ii) verify compliance with the classification criteria defined by the legislation, (iii) reclassify notifications, when necessary, in order for them to fit in with the legal definitions, (iv) verify registered companies in Brazil, (v) quantify the notifications according to the registered company and product lot, and (vi) identify the country of original of the notified product. Microsoft Excel® 2010 was used to categorize and systematize the data. Results: Some conceptual errors and incomplete records were found. Altogether, 228 notifications of technical complaints and 119 of adverse events were identified. Some notifications on guidewires and broken catheters were reported which led to the necessity of duplicating some medical procedures and to the occurrence of lesions/lacerations of vessels and tissue injury. Forty-seven percent of companies presented at least one notification in Notivisa and in all, 38 product lots had more than one notification. Conclusion: These data support a necessity for cooperation between all entities of the National Health Surveillance System to check compliance of this type of product and to properly report adverse events and technical complaints. It is also important to incorporate minimum standards for the management of technologies in health services, including in the acquisition of products and training of staff.