ABSTRACT Purpose: To evaluate the saccadic movements of patients with visual field loss due to primary open-angle glaucoma. Methods: Thirteen patients with good visual acuity (0.2 logMAR or better) (seven patients with primary open-angle glaucoma 65 ± 13 years) and six controls (51 ± 6 years) yielded a comprehensive ophthalmological examination, including Humphrey Visual Field tests (SITA-Standard 24-2), and performed a monocular, exploratory digital visual search task that quantifies the duration for finding the number “4” on a random array of digits distributed on the screen. After individual adjustments of the angle and distance positioning, the screen was spatially matched with the 24-2 visual field, and divided into five areas for analysis. During the task, saccades were simultaneously recorded in the same eye with a video-based eye tracker. Results: The patients with primary open-angle glaucoma showed a significantly higher number of saccades/screen (median ± interquartile range, 59.00 ± 29.00 vs. 32.50 ± 19.75 saccades (p=0.027) and visual search time per screen (38.50 ± 60.14 vs. 23.75 ± 8.90 seconds (p=0.035) than the controls did. Although the univariate analysis indicated a significant correlation with visual field mean deviation (coefficient=26.19 (p=0.02), only the visual search time/screen was significantly associated with the number of saccades/screen in the multivariate regression model (coefficient=0.55 (p<0.001). Overall, no significant correlation was observed between the sectorial number of saccades and the sensitivity of the five visual field areas. Conclusions: The patients with primary open-angle glaucoma show impaired search performance and showed a higher number of saccades needed to find stimuli when performing the exploratory visual task. Purpose openangle open Methods 0.2 02 0 2 (0. better seven 1 years 51 (5 examination SITAStandard SITA Standard 242, 242 24 , 24-2) monocular 4 “4 positioning 24- videobased video based tracker Results saccadesscreen median range 5900 59 00 59.0 2900 29 29.0 vs 3250 32 50 32.5 1975 19 75 19.7 p=0.027 p0027 p 027 (p=0.027 38.50 3850 38 (38.5 6014 60 14 60.1 2375 23 23.7 890 8 90 8.9 p=0.035 p0035 035 (p=0.035 did coefficient=26.19 coefficient2619 coefficient 26 (coefficient=26.1 p=0.02, p002 p=0.02 (p=0.02) timescreen coefficient=0.55 coefficient055 55 (coefficient=0.5 p<0.001. p0001 p<0.001 . 001 (p<0.001) Overall Conclusions 0. (0 5 ( “ 590 59. 290 29. 325 3 32. 197 7 19. (p=0.02 38.5 385 (38. 601 60. 237 23. 89 9 8. p=0.03 p003 03 (p=0.03 coefficient=26.1 coefficient261 (coefficient=26. p00 p=0.0 coefficient=0.5 coefficient05 (coefficient=0. p000 p<0.00 (p<0.001 (p=0.0 38. (38 coefficient=26. coefficient26 (coefficient=26 p0 p=0. coefficient=0. coefficient0 (coefficient=0 p<0.0 (p<0.00 (p=0. (3 coefficient=26 coefficient2 (coefficient=2 p=0 coefficient=0 (coefficient= p<0. (p<0.0 (p=0 coefficient=2 p= coefficient= (coefficient p<0 (p<0. (p= p< (p<0 (p (p<

ABSTRACT Objective: To evaluate the association of biomarkers with successful ventilatory weaning in COVID-19 patients. Methods: An observational, retrospective, and single-center study was conducted between March 2020 and April 2021. C-reactive protein, total lymphocytes, and the neutrophil/lymphocyte ratio were evaluated during attrition and extubation, and the variation in these biomarker values was measured. The primary outcome was successful extubation. ROC curves were drawn to find the best cutoff points for the biomarkers based on sensitivity and specificity. Statistical analysis was performed using logistic regression. Results: Of the 2,377 patients admitted to the intensive care unit, 458 were included in the analysis, 356 in the Successful Weaning Group and 102 in the Failure Group. The cutoff points found from the ROC curves were −62.4% for C-reactive protein, +45.7% for total lymphocytes, and −32.9% for neutrophil/lymphocyte ratio. These points were significantly associated with greater extubation success. In the multivariate analysis, only C-reactive protein variation remained statistically significant (OR 2.6; 95%CI 1.51 – 4.5; p < 0.001). Conclusion: In this study, a decrease in C-reactive protein levels was associated with successful extubation in COVID-19 patients. Total lymphocytes and the neutrophil/lymphocyte ratio did not maintain the association after multivariate analysis. However, a decrease in C-reactive protein levels should not be used as a sole variable to identify COVID-19 patients suitable for weaning; as in our study, the area under the ROC curve demonstrated poor accuracy in discriminating extubation outcomes, with low sensitivity and specificity. Objective COVID19 COVID 19 COVID-1 Methods observational retrospective singlecenter single center 202 2021 Creactive C reactive neutrophillymphocyte neutrophil lymphocyte measured specificity regression Results 2377 2 377 2,37 unit 45 35 10 624 62 4 −62.4 457 7 +45.7 329 32 9 −32.9 success OR 2.6 26 6 95CI CI 95 151 1 51 1.5 4.5 5 0.001. 0001 0.001 . 0 001 0.001) Conclusion However outcomes COVID1 COVID- 20 237 37 2,3 3 −62. +45. −32. 2. 15 1. 4. 000 0.00 00 23 2, −62 +45 −32 0.0 −6 +4 −3 0. − +

RESUMO Objetivo: Avaliar a associação de biomarcadores com o sucesso do desmame ventilatório em pacientes com COVID-19. Métodos: Trata-se de estudo observacional, retrospectivo e de centro único realizado entre março de 2020 e abril de 2021. Foram avaliados a proteína C-reativa, os linfócitos totais e a relação neutrófilos/linfócitos durante o atrito e a extubação; mediu-se a variação desses valores de biomarcadores. O desfecho primário foi o sucesso da extubação. As curvas ROC foram desenhadas para encontrar os melhores pontos de corte dos biomarcadores segundo a sensibilidade e a especificidade. A análise estatística foi realizada por meio de regressão logística. Resultados: Dos 2.377 pacientes admitidos na unidade de terapia intensiva, 458 foram incluídos na análise, 356 no Grupo Sucesso do desmame e 102 no Grupo Fracasso do desmame. Os pontos de corte encontrados nas curvas ROC foram −62,4% para proteína C-reativa, +45,7% para linfócitos totais e −32,9% para relação neutrófilo/linfócito. Esses pontos foram significativamente associados ao maior sucesso da extubação. Na análise multivariada, apenas a variação da proteína C-reativa permaneceu estatisticamente significativa (RC 2,6; IC95% 1,51 – 4,5; p < 0,001). Conclusão: Neste estudo, uma diminuição nos níveis de proteína C-reativa foi associada ao sucesso da extubação em pacientes com COVID-19. Os linfócitos totais e a relação neutrófilos/linfócitos não mantiveram a associação após a análise multivariada. No entanto, uma diminuição nos níveis de proteína C-reativa não deve ser usada como única variável para identificar pacientes com COVID-19 adequados para o desmame; como em nosso estudo, a área sob a curva ROC demonstrou baixa precisão na discriminação dos resultados de extubação, com baixas sensibilidade e especificidade. Objetivo COVID19. COVID19 COVID 19. 19 Métodos Tratase Trata se observacional 202 2021 Creativa, Creativa C reativa, reativa neutrófiloslinfócitos neutrófilos mediuse mediu especificidade logística Resultados 2377 2 377 2.37 intensiva 45 35 10 624 62 4 −62,4 457 7 +45,7 329 32 9 −32,9 neutrófilolinfócito neutrófilo linfócito neutrófilo/linfócito multivariada RC 2,6 26 6 IC95 IC 151 1 51 1,5 4,5 5 0,001. 0001 0,001 . 0 001 0,001) Conclusão entanto COVID-1 COVID1 20 237 37 2.3 3 −62, +45, −32, 2, IC9 15 1, 4, 000 0,00 00 COVID- 23 2. −62 +45 −32 0,0 −6 +4 −3 0, − +

Resumo Antecedentes A disfunção olfatória (DO) é uma manifestação frequente da doença do coronavírus 2019 (COVID-19). A apolipoproteína E (APOE) é uma proteína que interage com o receptor da enzima conversora de angiotensina, essencial para a entrada viral na célula. Publicações anteriores sugeriram um possível papel da APOE na gravidade da COVID-19. Até onde sabemos, nenhuma publicação encontrou associações significativas entre a gravidade dessa doença, DO e polimorfismos da APOE (E2, E3 e E4). Objetivo Analisar a epidemiologia da DO e sua relação com os polimorfismos do gene APOE em uma coorte de pacientes com COVID longa. Métodos Um estudo de coorte prospectiva com pacientes acompanhados em ambulatório neurológico pós-COVID, com DO sendo definida como uma redução subjetiva da função olfativa após a infecção e a DO persistente sendo definida quando a queixa durou mais de 3 meses após a resolução da infecção por COVID-19. Este estudo transversal é parte de uma pesquisa maior com dados anteriormente relatados, focando na performance cognitiva dos pacientes. Resultados Foram selecionados 221 pacientes para esse estudo, dos quais 186 haviam coletado amostras de sangue para genotipagem APOE. O grupo DO persistente foi mais jovem e apresentou menor taxa de internação na fase aguda da doença (p < 0,001). Além disso, a frequência do alelo E4 da APOE foi menor nesse grupo (p = 0,035). Este estudo avaliou a DO em uma população com COVID longa. Na literatura atual sobre essa doença, a anosmia está associada a melhores desfechos clínicos e o alelo E4 está associado a piores desfechos. Conclusão Nosso estudo acrescenta novas informações a essas correlações, sugerindo a APOE E4 como um fator de proteção para DO. (DO 201 COVID19. COVID19 19 . (COVID-19) (APOE angiotensina célula 19. COVID-19 sabemos E2, E2 (E2 E4. E4) longa pósCOVID, pósCOVID pós COVID, pós-COVID relatados 22 18 p 0,001. 0001 0,001 0 001 0,001) disso 0,035. 0035 0,035 035 0,035) correlações 20 COVID1 1 (COVID-19 COVID-1 (E 2 000 0,00 00 003 0,03 03 (COVID-1 COVID- 0,0 (COVID- 0, (COVID

Abstract Background Olfactory dysfunction (OD) represents a frequent manifestation of the coronavirus disease 2019 (COVID-19). Apolipoprotein E (APOE) is a protein that interacts with the angiotensin-converting enzyme receptor, essential for viral entry into the cell. Previous publications have suggested a possible role of APOE in COVID-19 severity. As far as we know, no publications found significant associations between this disease's severity, OD, and APOE polymorphisms (E2, E3, and E4). Objective To analyze the epidemiology of OD and its relationship with APOE polymorphisms in a cohort of Long-COVID patients. Methods We conducted a prospective cohort study with patients followed in a post-COVID neurological outpatient clinic, with OD being defined as a subjective reduction of olfactory function after infection, and persistent OD being defined when the complaint lasted more than 3 months after the COVID-19 infection resolution. This cross-sectional study is part of a large research with previously reported data focusing on the cognitive performance of our sample. Results The final sample comprised 221 patients, among whom 186 collected blood samples for APOE genotyping. The persistent OD group was younger and had a lower hospitalization rate during the acute phase of the disease (p < 0.001). Furthermore, the APOE variant E4 allele frequency was lower in this group (p = 0.035). This study evaluated OD in an outpatient population with COVID-19. In the current literature on this disease, anosmia is associated with better clinical outcomes and the E4 allele is associated with worse outcomes. Conclusion Our study provides new information to these correlations, suggesting APOE E4 as a protective factor for OD. (OD 201 COVID19. COVID19 COVID 19 . (COVID-19) (APOE angiotensinconverting angiotensin converting receptor cell COVID-1 severity know diseases s E2, E2 (E2 E3 E4. E4) LongCOVID Long postCOVID post clinic resolution crosssectional cross sectional 22 18 genotyping p 0.001. 0001 0.001 0 001 0.001) Furthermore 0.035. 0035 0.035 035 0.035) 19. correlations 20 COVID1 1 (COVID-19 COVID- (E 2 000 0.00 00 003 0.03 03 (COVID-1 0.0 (COVID- 0. (COVID

ABSTRACT Purpose to analyze how socioeconomic, pregnancy and childbirth factors relate to the feeding situation in the sixth month of life of full-term babies. Methods longitudinal observational study, with 98 mothers of full-term babies. Data collection was structured by capturing information regarding the clinical history and moment of birth in the babies' medical records, followed by the application of two questionnaires to the postpartum women, with questions regarding sociodemographic data, pre- and post-pregnancy data and the baby's nutrition. baby, the first being answered during hospital stay and the second, by telephone, in the 6th month of life. A descriptive analysis of the data was performed, using the frequency distribution of categorical variables, inferential analysis using Pearson's Chi-square test and multivariate analysis using binary logistic regression, adopting, for inclusion in the final model, the significance level of 5%. Results there was an association between exclusive breastfeeding in the 6th month and maternal education and between the period of food introduction and family income. Mothers with higher education were 4.82 times more likely to breastfeed their children exclusively until the sixth month. Families with lower income (up to one minimum wage) were 2.54 times more likely to start food introduction before the sixth month than families with higher income. Conclusion higher maternal education was a predictive factor for exclusive breastfeeding at the 6th month and higher military income was a predictive factor for introducing food after the 6th month. socioeconomic fullterm full term babies study 9 records women pre postpregnancy post babys baby s nutrition second telephone th performed variables Pearsons Pearson Chisquare Chi square regression adopting model 5 5% 482 4 82 4.8 up wage 254 2 54 2.5 48 8 4. 25 2.

RESUMO Objetivo analisar como os fatores socioeconômicos, da gestação e do parto se relacionam com a situação da alimentação no sexto mês de vida de bebês nascidos a termo. Método estudo observacional longitudinal, com 98 mães de bebês termos. A coleta de dados foi estruturada pela captação das informações referentes à história clínica e ao momento do parto nos prontuários dos bebês, seguida da aplicação de dois questionários, com questões referentes a dados sociodemográficos, dados pré e pós-gestacionais e da alimentação do bebê, sendo o primeiro respondido durante a internação hospitalar e o segundo, por contato telefônico, no 6° mês de vida. Foi realizada análise descritiva dos dados, por meio da distribuição de frequência das variáveis categóricas, análise inferencial utilizando o teste Qui-quadrado de Pearson e análise multivariada por regressão logística binária, adotando-se, para inclusão no modelo final, o nível de significância de 5%. Resultados houve associação entre aleitamento materno exclusivo no 6º mês e escolaridade materna e entre o início da introdução alimentar e a renda familiar. Mães com ensino superior apresentaram 4,82 vezes mais chances de amamentarem os filhos de forma exclusiva até o sexto mês. Famílias de menor renda (até um salário mínimo) tiveram 2,54 vezes mais chances de iniciarem a introdução alimentar antes do sexto mês do que as famílias de maior renda. Conclusão maior escolaridade materna foi fator preditor para o aleitamento materno exclusivo ao 6º mês e maior renda familiar foi fator preditor para introdução alimentar após o 6º mês. socioeconômicos termo longitudinal 9 termos questionários sociodemográficos pósgestacionais pós gestacionais bebê segundo telefônico 6 categóricas Quiquadrado Qui quadrado binária adotandose, adotandose adotando se, adotando-se final 5 5% º 482 4 82 4,8 mínimo 254 2 54 2,5 48 8 4, 25 2,

ABSTRACT Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses within a 28-day interval. IC received two additional BNT162b2 doses and H received a third BNT162b2 dose (booster). Blood samples were collected at baseline, 28 days after each dose, pre-booster and at the trial end. We used three serological tests to detect antibodies to SARS-CoV-2 nucleocapsid (N), trimeric spike (S), and receptor binding domain (RBD). Outcomes included seroconversion rates (SCR), geometric mean titers (GMT) and GMT ratio (GMTR). A total of 241 IC and 100 H adults participated in the study. After two CoronaVac doses, IC had lower SCR than H: anti-N, 33.3% vs 79%; anti-S, 33.8% vs 86%, and anti-RBD, 48.5% vs 85%, respectively. IC also showed lower GMT than H: anti-N, 2.3 vs 15.1; anti-S, 58.8 vs 213.2 BAU/mL; and anti-RBD, 22.4 vs 168.0 U/mL, respectively. After the 3rd and 4th BNT162b2 doses, IC had significant anti-S and anti-RBD seroconversion, but still lower than H after the 3rd dose. After boosting, GMT increased in IC, but remained lower than in the H group. CoronaVac two-dose schedule immunogenicity was lower in IC than in H. BNT162b2 heterologous booster enhanced immune response in both groups. COVID19 COVID 19 COVID-1 scarce BNTb BNT b BNT162b (IC (H SOT, SOT , (SOT) cancer comparison 28day day interval booster. . (booster) baseline 2 prebooster pre end SARSCoV2 SARSCoV SARS CoV SARS-CoV- N, N (N) S, S (S) RBD. RBD (RBD) SCR, (SCR) (GMT GMTR. GMTR (GMTR) 24 10 study antiN, antiN anti anti-N 333 33 3 33.3 79% 79 antiS, antiS 338 8 33.8 86 86% antiRBD, antiRBD RBD, 485 48 5 48.5 85 85% respectively 23 2. 15.1 151 15 1 588 58 58. 2132 213 213. BAU/mL BAUmL BAU mL 224 22 4 22. 1680 168 0 168. UmL U U/mL rd th boosting twodose groups COVID1 COVID- (SOT (booster SARS-CoV (N (S (RBD (SCR (GMTR 33. 7 48. 15. 21 16

Abstract Introduction The COVID-19 pandemic has disproportionately affected individuals residing in Long-Term Care Facilities (LTCFs), necessitating tailored strategies to manage outbreaks. This study examines the outcomes of the ILPI BH project, a collaborative effort between the Municipal Health Department and the Hospital das Clínicas of the Federal University of Minas Gerais, designed to mitigate COVID-19 spread within LTCFs. Methods Prospective cohort of secondary data: 1,794 old residents in 99 long-term care facilities of Belo Horizonte, Brazil, were followed from May 2020 to January 2021. The study analyzed the prevention strategies, residents’ clinical data, and the characteristics of the long-term care facilities, correlating these variables with the number of infections, hospitalizations, and deaths from COVID-19. It checked absolute numbers and rates of incidence, hospitalization, mortality, and lethality. Results There have been 58 COVID-19 outbreaks in long-term care facilities. There were 399 cases among residents, 96 hospitalizations for COVID-19 and 48 deaths from COVID-19 (2.7 % of the cohort), with a case fatality rate of 12 %. After multivariate analysis, the intrinsic variables to residents associated with higher mortality risk were higher degree of frailty (OR=1.08; p = 0.004) and the fact of living in a long-term care facility with a considerable proportion of residents’ coverage by health plans (OR = 1.01; p = 0.028). Early geriatric follow-up showed an association with a reduction in the number of hospitalizations due to COVID-19. Conclusion The correct classification of the degree of frailty of institutionalized older people seems to have been relevant for predicting mortality from COVID-19. The extensive assistance by private health plans, contrary to what is supposed, did not result in better health protection. Early geriatric follow-up was beneficial and may be an attractive strategy in the face of health emergencies that affect long-term care facilities to reduce hospital admissions. COVID19 COVID 19 COVID-1 LongTerm Long Term LTCFs, LTCFs , (LTCFs) project Gerais data 1794 1 794 1,79 9 longterm long term Horizonte Brazil 202 2021 infections COVID19. 19. incidence hospitalization lethality 5 39 4 2.7 27 2 7 (2. cohort, cohort) analysis OR=1.08 OR108 OR 08 (OR=1.08 0.004 0004 0 004 1.01 101 01 0.028. 0028 0.028 . 028 0.028) followup follow up supposed protection admissions COVID1 COVID- (LTCFs 179 79 1,7 20 3 2. (2 OR=1.0 OR10 (OR=1.0 0.00 000 00 1.0 10 002 0.02 02 17 1, ( OR=1. OR1 (OR=1. 0.0 1. OR=1 (OR=1 0. OR= (OR=

RESUMO Objetivo: Frente à importância dos catálogos bibliográficos para a mediação da informação, este trabalho visa a analisar os Catálogos Online de Acesso Público (Online Public Access Catalog - OPAC) das bibliotecas universitárias do estado de São Paulo de IES que oferecem graduação em Música. Método: Dentre as 28 instituições paulistas consultadas on-line, 10 não possuíam OPAC. Dessa forma, foram analisados 18 catálogos, partindo de metodologia exploratória e qualiquantitativa e tendo como base o conceito de infoeducação, a partir de 12 categorias adaptadas da literatura e elencadas a priori. Resultado: foi possível observar que as OPACs priorizam a busca, a identificação e o acesso aos registros bibliográficos, funcionando em um modelo de biblioteca emporium, ou seja, preocupado com a difusão da informação. A busca por tipologias documentais é admitida em 77,78% dos catálogos, mas apenas 33,3% permitem recuperar formações instrumentais. Recursos personalizados são mais raros, como salvar histórico de busca (44,44%) e personalizar a pesquisa (11,11%). A integração com mídias sociais é utilizada em 33,3% dos catálogos e recursos semelhantes à Web 2.0, em 66,7%. Conclusões: elementos mais sofisticados de análise poderiam ter sido utilizados, em especial os referentes aos próprios recursos Web, mas esses estariam fora do contexto dos atuais OPACs, que se mostraram estar aquém dos dispositivos digitais atuais. Acredita-se que os catálogos de acesso público precisam repensar suas ferramentas enquanto ato político de formação da identidade cidadã dos usuários a que servem, atuando como forum, em prol da mediação e da formação do graduando em Música. Objetivo informação OPAC Música Método 2 online, online on line, line on-line 1 forma infoeducação priori Resultado emporium seja 7778 77 78 77,78 333 33 3 33,3 instrumentais raros 44,44% 4444 44 (44,44% 11,11%. 1111 11,11% . 11 (11,11%) 20 0 2.0 667 66 7 66,7% Conclusões utilizados Acreditase Acredita servem forum 777 77,7 33, 44,44 444 4 (44,44 111 11,11 (11,11% 2. 6 66,7 77, 44,4 (44,4 11,1 (11,11 66, 44, (44, 11, (11,1 (44 (11, (4 (11 ( (1

ABSTRACT Objective: Given the importance of bibliographic catalogues for the mediation of information, this work aims to analyse São Paulo State university library OPACs from HEIs that offer degrees in Music. Methods: Among the 28 São Paulo institutions consulted online, 10 did not have an OPAC. In this way, 18 catalogues were analysed, using an exploratory and qualitative methodology, and based on the concept of infoeducation, based on 12 categories adapted from the literature and listed a priori. Results: it was possible to observe that the analysed OPACs prioritize the search, identification, and access to bibliographic records, operating in an emporium library model, that is, concerned with the dissemination of information. The search for documentary typologies is supported in 77.78% of the catalogues, but only 33.3% allow the retrieval of instrumental formations. Customized features are rarer, such as saving search history (44.44%), and customizing the search (11.11%). Integration with social media is used in 33.3% of catalogues, and resources similar to Web 2.0, in 66.7%. Conclusions: more sophisticated elements of analysis could have been used, especially those referring to the Web resources themselves, but these would be outside the context of current OPACs, which have proven to be below current digital devices. It is believed that public access catalogues need to rethink their tools as a political act of forming the citizen identity of the users they serve, acting as a forum, in favour of music graduates' mediation and training. Objective information Music Methods 2 online 1 OPAC way methodology infoeducation priori Results identification records model 7778 77 78 77.78 333 33 3 33.3 formations rarer 44.44%, 4444 44.44% , 44 (44.44%) 11.11%. 1111 11.11% . 11 (11.11%) 20 0 2.0 667 66 7 66.7% Conclusions themselves devices serve forum graduates training 777 77.7 33. 444 44.44 4 (44.44% 111 11.11 (11.11% 2. 6 66.7 77. 44.4 (44.44 11.1 (11.11 66. 44. (44.4 11. (11.1 (44. (11. (44 (11 (4 (1 (

ABSTRACT Purpose: to investigate the prevalence of exclusive breastfeeding up to 6 months old in full-term newborns at a public hospital and the main factors associated with early weaning, during the pandemic caused by severe acute respiratory syndrome. Methods: an observational, cross-sectional study with 98 mothers of full-term babies, conducted from January to August 2021, during the COVID-19 pandemic. The participants answered two structured questionnaires. One was applied immediately after childbirth, with questions on identification and socioeconomic data, obstetric-gynecological background, and current pregnancy and childbirth. The second questionnaire, applied 6 months after childbirth, had questions about the child's feeding status. Statistical tests were used to associate the prevalence of exclusive breastfeeding up to 6 months old and other variables, at the 5% significance level. Results: 16.3% of the babies were exclusively breastfeeding until the sixth month, during the COVID-19 pandemic, in the public hospital where the study was carried out. Exclusive breastfeeding up to 6 months old was not associated with the study variables. Conclusion: the prevalence of exclusive breastfeeding until the sixth month in full-term babies, in a public hospital, during the COVID-19 pandemic, was 16.3%. None of the variables analyzed was associated with early weaning. Purpose fullterm full term weaning syndrome Methods observational crosssectional cross sectional 9 2021 COVID19 COVID 19 COVID-1 questionnaires childbirth data obstetricgynecological obstetric gynecological background questionnaire childs child s status 5 level Results 163 16 3 16.3 out Conclusion 202 COVID1 1 COVID- 16. 20 2

RESUMO Objetivo: investigar a prevalência de aleitamento materno exclusivo aos seis meses de vida em bebês nascidos a termo em um hospital público e os principais fatores associados ao desmame precoce em período de pandemia causada pela síndrome respiratória aguda grave. Métodos: estudo observacional, transversal, realizado com 98 mães de bebês a termo, no período de janeiro a agosto de 2021, intervalo marcado pela pandemia da COVID-19. As participantes responderam a dois questionários, um no pós-parto imediato, com questões de identificação e socioeconômicas, antecedentes gineco-obstétricos, gestação e parto atual; e, o segundo, seis meses após o parto, continha questões sobre a situação alimentar da criança. Para verificar a associação entre a prevalência do aleitamento materno exclusivo aos seis meses de vida e as demais variáveis foram aplicados os testes Qui-quadrado, Exato de Fisher, Qui-quadrado de comparações múltiplas e Teste T, com nível de significância de 5%. Resultados: 16,3% dos lactentes encontravam-se em aleitamento materno exclusivo no sexto mês, no período da pandemia da COVID-19, no hospital público onde o estudo foi realizado. Não houve associação entre o aleitamento materno exclusivo aos seis meses de vida e as variáveis pesquisadas. Conclusão: a prevalência de amamentação exclusiva no sexto mês em bebês nascidos a termo em um hospital público, durante a pandemia da COVID-19, foi de 16,3% e nenhuma das variáveis analisadas apresentou associação com o desmame precoce. Objetivo grave Métodos observacional transversal 9 2021 COVID19. COVID19 COVID 19. 19 COVID-19 questionários pósparto pós imediato socioeconômicas ginecoobstétricos, ginecoobstétricos gineco obstétricos, obstétricos gineco-obstétricos atual segundo criança Quiquadrado, Quiquadrado Qui quadrado, quadrado Fisher T 5 5% Resultados 163 16 3 16,3 encontravamse encontravam se COVID19, 19, pesquisadas Conclusão 202 COVID1 1 COVID-1 16, 20 COVID- 2

ABSTRACT Overcoming malnutrition in all its forms, which is also manifested in the obesity epidemic, is one of the priorities of the 2030 Agenda and the Sustainable Development Goals. This article presents reflections on food insecurity in Brazil, based on topics such as population growth, climate change, biodiversity and traditional and regenerative food systems; it also addresses the role of social initiatives to guarantee the Human Right to Adequate Food. The Nutrition and Poverty Research Group, Planetary Health - Brazil Group, and the Center for Artificial Intelligence (C4AI) - AgriBio Axis, assume that the organized and systemic resumption of the initiatives mentioned out in this position paper can contribute to the articulation between research, public policies and services, to combat all forms of malnutrition, as a complex and priority problem to ensure social welfare. epidemic 203 Goals growth change systems Food Group C4AI CAI C AI (C4AI Axis research services welfare 20 2

RESUMO O combate à má alimentação em todas as suas formas, que também se expressa na epidemia da obesidade, é uma das prioridades da Agenda 2030 e dos Objetivos de Desenvolvimento Sustentável. Este artigo traz elementos sobre insegurança alimentar no Brasil, a partir de temas relativos ao crescimento populacional, mudanças climáticas, biodiversidade e sistemas alimentares tradicionais e regenerativos; trata também do papel dos movimentos sociais para a garantia do Direito Humano à Alimentação Adequada. O Grupo de Pesquisa em Nutrição e Pobreza, o Saúde Planetária Brasil, e o Centro de Inteligência Artificial (C4AI) - Eixo AgriBio, entendem que a retomada organizada e sistêmica das frentes apontadas neste artigo de posicionamento, pode constituir um caminho para a articulação entre pesquisa, serviço e políticas públicas na direção do combate à fome e às demais manifestações da má alimentação, enquanto problema complexo prioritário para a garantia do bem-estar social. formas obesidade 203 Sustentável Brasil populacional climáticas regenerativos Adequada Pobreza C4AI CAI C AI (C4AI AgriBio posicionamento pesquisa bemestar bem estar social 20 2

Abstract The scope of this article is to investigate the prevalence of the experience of forced sexual intercourse on life and its possible consequences on mental and sexual health among undergraduate students at a public university in Brazil. It is a quantitative cross-sectional study with 996 undergraduate students. Sampling was carried out systematically by single-stage clusters. Descriptive, bivariate and multivariate analyses were performed using the Poisson Regression model, and the etiological fractions of the consequences of forced sexual intercourse were calculated. The lifetime prevalence of forced sexual intercourse was 12.1%. Female sex, non-heterosexual sexual orientation, first sexual intercourse before the age of 14, child food insecurity and domestic violence were associated with a higher prevalence of the outcome. Individuals who experienced forced sexual intercourse were more likely to be diagnosed with sexually transmitted infections and to represent a potential suicide risk. The study revealed the problems of sexual violence in the university context. Brazil crosssectional cross sectional 99 singlestage single stage clusters Descriptive model calculated 121 12 1 12.1% sex nonheterosexual non heterosexual orientation 14 outcome risk context 9 12.1 12.

Resumo O objetivo deste artigo é investigar a prevalência de relação sexual forçada na vida e suas possíveis consequências na saúde mental e sexual em acadêmicos de cursos de graduação de uma universidade pública no Brasil. Estudo transversal quantitativo com 996 estudantes de graduação. A amostragem realizada de forma sistemática por conglomerados. Foi usado o modelo de Regressão de Poisson, e foram calculadas as frações etiológicas das consequências de relação sexual forçada. A prevalência de relação sexual forçada ao longo da vida foi de 12,1%. Sexo feminino, orientação sexual não heterossexual, primeira relação sexual antes de 14 anos de idade, insegurança alimentar e violência no contexto doméstico na infância foram associados à maior prevalência do desfecho. Indivíduos que sofreram relação sexual forçada foram mais propensos a apresentar diagnóstico de infecções sexualmente transmissíveis e de ter risco de suicídio. O estudo evidenciou a problemática da violência sexual no contexto universitário. Brasil 99 conglomerados Poisson 121 12 1 12,1% feminino heterossexual idade desfecho suicídio universitário 9 12,1 12,

ABSTRACT COVID-19 is commonly associated with high serum levels of pro-inflammatory cytokines, and the post-infection status can disturb self-tolerance and trigger autoimmune responses. We are reporting a 45-year-old male who was admitted with fatigue, jaundice, elevated liver enzymes (with cholestatic pattern), and acute kidney injury two weeks after recovering from a mild SARS-CoV-2 infection. Serologies for viral hepatitis and anti-mitochondrial antibody were negative, while anti-nuclear and anti-smooth muscle antibodies were positive. There were no signs of chronic liver disease, and a magnetic resonance cholangiography showed no dilatation of biliary ducts. Histologic evaluation of the liver evidenced numerous foci of lobular necrosis without ductopenia or portal biliary reaction. Considering the autoantibody profile and histologic changes, the medical team started oral prednisone, but there was a suboptimal biochemical response in the outpatient follow-up. Two months later, a second liver biopsy was performed and revealed non-suppurative destructive chronic cholangitis, extensive areas of confluent necrosis with hepatocytes regenerating into pseudorosettes, and numerous plasma cells. According to the Paris Criteria, the patient was then diagnosed with an autoimmune hepatitis-primary biliary cholangitis overlap syndrome (AIH-PBC-OS). After adding azathioprine and ursodeoxycholic acid to the treatment, there was a satisfactory response. This is the second worldwide report of an AIH-PBC-OS triggered by COVID-19, but the first case with a negative anti-mitochondrial antibody. In this setting, histologic evaluation of the liver by an experienced pathologist is a hallmark of achieving the diagnosis and correctly treat the patient. COVID19 COVID 19 COVID-1 proinflammatory pro inflammatory cytokines postinfection post infection selftolerance self tolerance responses 45yearold yearold 45 year old fatigue jaundice pattern, pattern , pattern) SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- antimitochondrial anti mitochondrial antinuclear nuclear antismooth smooth positive disease ducts reaction changes prednisone followup. followup follow up. up follow-up later nonsuppurative non suppurative pseudorosettes cells Criteria hepatitisprimary primary AIHPBCOS. AIHPBCOS AIH PBC OS . (AIH-PBC-OS) treatment COVID19, 19, setting COVID1 1 COVID- 4 SARS-CoV (AIH-PBC-OS

ABSTRACT BACKGROUND: Part of colorectal cancer cases occurs due to modifications in the DNA mismatch repair system, which are responsible for microsatellite instability. This alteration results in an unconventional phenotypic pattern of colorectal cancer. AIMS: To describe the epidemiological, histopathological and molecular profiles of patients with colorectal cancer who underwent surgical treatment in a reference hospital. METHODS: This is a cross-sectional, retrospective study with a quantitative approach, that included a review of patients’ medical records who underwent oncological surgery for colorectal cancer. RESULTS: A total of 122 colorectal cancer cases were identified, with microsatellite instability detected in 8.2% of the sample. The gender distribution was similar, with 52.46% males, and the weighted average age was 63 years (standard deviation±11.65). However, in the microsatellite instability group, the predominant age was below 60 years. Regarding the histological type, adenocarcinoma not otherwise specified accounted for 80.33% of the cases, being the most prevalent in both groups, with the mucinous type being more frequent among the instability cases. The pT3 pathological staging (46.72%) was the most predominant. The topography was more prevalent on the left (60.66%), but there was a significant difference when compared to the group with microsatellite instability, in which 80% of the neoplasms were located on the right (p=0.006). CONCLUSIONS: Differences in age and neoplastic topography found in microsatellite instability samples highlight the distinctive presentation pattern of the disease. Recognizing these characteristics is essential for developing prevention strategies, in addition to early and accurate diagnosis of colorectal cancer. BACKGROUND system AIMS epidemiological hospital METHODS crosssectional, crosssectional cross sectional, sectional cross-sectional approach RESULTS 12 identified 82 8 2 8.2 sample similar 5246 52 46 52.46 males 6 standard deviation±11.65. deviation1165 deviation deviation±11.65 . 11 65 deviation±11.65) However 8033 80 33 80.33 groups pT 46.72% 4672 72 (46.72% 60.66%, 6066 60.66% , 66 (60.66%) p=0.006. p0006 p p=0.006 0 006 (p=0.006) CONCLUSIONS disease strategies 1 8. 524 5 4 52.4 deviation116 deviation±11.6 803 3 80.3 46.72 467 7 (46.72 606 60.66 (60.66% p000 p=0.00 00 (p=0.006 52. deviation11 deviation±11. 80. 46.7 (46.7 60.6 (60.66 p00 p=0.0 (p=0.00 deviation1 deviation±11 46. (46. 60. (60.6 p0 p=0. (p=0.0 deviation±1 (46 (60. p=0 (p=0. deviation± (4 (60 p= (p=0 ( (6 (p= (p

RESUMO RACIONAL: Parte dos casos de câncer colorretal ocorre devido a alterações nas enzimas de reparo do DNA, responsáveis pela instabilidade de microssatélites. Esta alteração resulta em um padrão fenotípico não convencional de câncer colorretal. OBJETIVOS: Descrever os aspectos epidemiológicos, histopatológicos e moleculares dos pacientes com câncer colorretal submetidos a tratamento cirúrgico em hospital de referência. MÉTODOS: Trata-se de um estudo transversal, retrospectivo com abordagem quantitativa, com revisão de prontuários médicos de pacientes submetidos a cirurgia oncológica por câncer colorretal. RESULTADOS: Foram registrados 122 casos de câncer colorretal, com instabilidade de microssatélites detectada em 8,2% da amostra. A distribuição por sexo foi semelhante, sendo 52,46% do sexo masculino, e média ponderada de idade de 63 anos (±11,65), contudo no grupo com instabilidade, a faixa etária predominante foi abaixo de 60 anos. Em relação ao tipo histológico, o adenocarcinoma sem outra especificação representou 80,33% dos casos, sendo o mais prevalente em ambos os grupos, mas com maior frequência do tipo mucinoso em caso de instabilidade. O estadiamento patológico pT3 (46,72%) foi predominante. A topografia da neoplasia foi mais prevalente à esquerda (60,66%), mas houve diferença significativa em relação ao grupo com instabilidade de microssatélites, no qual 80% das neoplasias localizavam-se à direita (p=0,006019). CONCLUSÕES: As diferenças de idade e topografia neoplásica encontradas nas amostras com instabilidade de microssatélites destacam o padrão não habitual de apresentação da doença. O conhecimento, portanto, dessas distinções é necessário para o desenvolvimento de estratégias de prevenção, além de diagnóstico precoce e preciso do câncer colorretal. RACIONAL DNA OBJETIVOS epidemiológicos referência MÉTODOS Tratase Trata se transversal quantitativa RESULTADOS 12 82 8 2 8,2 amostra semelhante 5246 52 46 52,46 masculino 6 ±11,65, 1165 ±11,65 , 11 65 (±11,65) histológico 8033 80 33 80,33 grupos pT 46,72% 4672 72 (46,72% 60,66%, 6066 60,66% 66 (60,66%) localizavamse localizavam p=0,006019. p0006019 p p=0,006019 . 0 006019 (p=0,006019) CONCLUSÕES doença conhecimento portanto prevenção 1 8, 524 5 4 52,4 116 ±11,6 (±11,65 803 3 80,3 46,72 467 7 (46,72 606 60,66 (60,66% p000601 p=0,00601 00601 (p=0,006019 52, ±11, (±11,6 80, 46,7 (46,7 60,6 (60,66 p00060 p=0,0060 0060 (p=0,00601 ±11 (±11, 46, (46, 60, (60,6 p0006 p=0,006 006 (p=0,0060 ±1 (±11 (46 (60, p000 p=0,00 00 (p=0,006 ± (±1 (4 (60 p00 p=0,0 (p=0,00 (± ( (6 p0 p=0, (p=0,0 p=0 (p=0, p= (p=0 (p= (p

Abstract Mollinedia (Monimiaceae) presents numerous microendemic species, and its centre of diversity is in the Brazilian Atlantic rainforest, where more than half of the species occur. The taxonomy of microendemic species can be challenging because their morphological and genetic variations can be interpreted as a response to geographic isolation rather than a circumscription for different species. In this paper, we describe Mollinedia pignalii Lírio & Pauli, a microendemic species from the Espírito Santo state, Brazil. Vegetatively, M. pignalii is similar to Mollinedia elegans Tul. and Mollinedia schottiana (Spreng.) Perkins; however, it presents the following differences: white-puberulous leaves, staminate flowers with a flat receptacle and 6 to 14 stamens, white-puberulous pistillate flowers with a cupuliform receptacle and 8 to 22 carpels, and white-puberulous drupelets. Due to the similarity between the three species, M. pignalii has been collected and deposited in herbaria under different names. Here, we describe the new species based on morphology and genome size, a comparison with similar species, and ecological comments in an integrative approach. We also provide its conservation status and an identification key for the species of Monimiaceae occurring in the state of Espírito Santo. (Monimiaceae rainforest occur paper Pauli Brazil Vegetatively M Tul Spreng. Spreng (Spreng. Perkins however differences whitepuberulous white puberulous leaves 1 stamens 2 carpels drupelets names Here size approach (Spreng

■ ABSTRACT Introduction: The demand for body contouring surgery after bariatric surgery is largely due to dissatisfaction with body image impaired by sagging and excess skin resulting from massive weight loss. This study aimed to evaluate the quality of life and body image of patients undergoing bariatric surgery and body contouring surgery in a private clinic. Method: This cross-sectional study compared 4 groups of 21 patients, matched by body mass index and age before undergoing bariatric surgery. They were divided into times before/after bariatric surgery and before/after body contouring surgery, thus forming groups A, B, C, and D, respectively. The SF-36 questionnaire assessed the quality of life, and the Silhouette Scale proposed by Kakeshita to assess body image. For the significance level, p<0.05 was chosen. Results: There was an improvement in all SF-36 domains after bariatric surgery. Patients who sought body contouring surgery had the lowest mental health component value, with little change after body contouring surgery. Almost all groups overestimated their silhouette, except for the group of 6 months after bariatric surgery, which saw itself as smaller. Conclusion: Bariatric patients seeking body contouring surgery have lower mental health-related quality of life scores that remain lower after body contouring surgery. Introduction loss clinic Method crosssectional cross sectional 2 beforeafter A B C D respectively SF36 SF 36 SF-3 level p005 p 0 05 p<0.0 chosen Results value silhouette smaller Conclusion healthrelated related SF3 3 SF- p00 p<0. p0 p<0 p<

■ RESUMO Introdução: A procura pela cirurgia de contorno corporal após a cirurgia bariátrica se deve em grande parte a uma insatisfação com a imagem corporal prejudicada pela flacidez e excesso de pele decorrente da grande perda ponderal. O objetivo deste estudo foi avaliar a qualidade de vida e a imagem corporal de pacientes submetidos a cirurgia bariátrica e posteriormente a cirurgia de contorno corporal em uma clínica privada. Método: Este estudo transversal comparou 4 grupos distintos de 21 pacientes cada, pareados por índice de massa corporal e idade antes de realizarem a cirurgia bariátrica. Foram divididos nos tempos antes/depois da cirurgia bariátrica e antes/depois da cirurgia de contorno corporal, formando assim os grupos A, B, C e D, respectivamente. Foi utilizado o questionário SF-36 para avaliação da qualidade de vida e a Escala de Silhuetas proposta por Kakeshita para avaliação da imagem corporal. Para o nível de significância, foi escolhido p<0,05. Resultados: Houve melhora em todos os domínios do SF-36 após a cirurgia bariátrica. Os pacientes que procuraram a cirurgia de contorno corporal apresentaram o menor valor do componente de saúde mental, com pouca alteração após a cirurgia de contorno corporal. Quase todos os grupos superestimaram a sua silhueta, exceto para o grupo de 6 meses após a cirurgia bariátrica, que se viu menor. Conclusão: Pacientes bariátricos que procuram a cirurgia de contorno corporal apresentam escores inferiores de qualidade de vida relacionada à saúde mental e que permanecem menores após a cirurgia de contorno corporal. A distorção da imagem corporal e expectativas irreais podem justificar esse achado. Introdução ponderal privada Método 2 cada antesdepois depois B D respectivamente SF36 SF 36 SF-3 significância p005 p 0 05 p<0,05 Resultados silhueta Conclusão achado SF3 3 SF- p00 p<0,0 p0 p<0, p<0 p<

Resumen Este artículo es el resultado de una investigación relacionada con la experiencia de alfabetización de adultos realizada en Brasilia en sus inicios. Establecida en 1963, bajo la coordinación de Paulo Freire, esta experiencia se constituyó el embrión del Programa Nacional de Alfabetización (PNA) propuesto por el gobierno de João Goulart. La averiguación que sirve de base a este estudio se desarrolló a través del análisis documental, guiada por la concepción crítica del método historiográfico. Los datos obtenidos dialogan con los recogidos en el “Dosier Paulo Freire”, cedido por la profesora Maria de Souza Duarte al acervo del Museo de Educación del Distrito Federal. Este dosier consta de una colección de fotografías de los primeros círculos de cultura en Brasilia, así como de reuniones de las autoridades, a nivel federal, responsables por el PNA, además de documentos textuales relacionados con el objeto investigado. La riqueza de datos encontrada sobre Paulo Freire demuestra la importancia de su paso por la nueva capital y el carácter emancipador del proyecto. La brusca interrupción de la experiencia por el golpe de 1964 impidió la continuidad de las políticas públicas de alfabetización de adultos en curso en Brasil, además de imponer el término de la presencia del educador en la capital del país durante la dictadura militar. inicios 1963 PNA (PNA Goulart documental historiográfico Dosier , Freire” Federal autoridades federal investigado proyecto 196 Brasil militar 19 1

Abstract The present study is the result of an investigation related to the adult literacy experience carried out in Brasilia in its early days. Initiated in 1963, under the supervision of Paulo Freire, the experience constituted the very embryo of the National Literacy Program (PNA), proposed by the João Goulart administration. The research that served as the cornerstone for this study was developed through document analysis, guided by a critical conception of the historiographical method. Data obtained interact with those collected in the Dossier Paulo Freire, granted by Professor Maria de Souza Duarte to the collection of the Museum of Education of the Federal District. The dossier consists of a collection of photographs of the first culture circles in Brasilia, as well as meetings at the federal level of the authorities responsible for the PNA, in addition to textual documents related to our researched object. The wealth of data found regarding Paulo Freire demonstrates the importance of his passage through the new capital and the emancipatory character of the literacy project. The abrupt interruption of the experience by the 1964 military coup prevented the continuity of public policies for adult literacy underway in Brazil, imposing the erasure of the presence of the educator in the country's capital during the military dictatorship. days 1963 PNA , (PNA) administration analysis method District object project 196 Brazil countrys country s dictatorship (PNA 19 1

Resumo O presente artigo resulta de investigação relativa à experiência de alfabetização de adultos realizada em Brasília nos seus primórdios. Iniciada em 1963, sob a coordenação de Paulo Freire, essa experiência constituiu o embrião do Programa Nacional de Alfabetização (PNA), proposto pelo governo João Goulart. A pesquisa que serve de base para este estudo se desenvolveu mediante análise documental, orientada pela concepção crítica do método historiográfico. Os dados obtidos dialogam com os coletados no “Dossiê Paulo Freire”, concedido pela professora Maria de Souza Duarte ao acervo do Museu da Educação do Distrito Federal. Esse dossiê é composto por uma coleção de fotografias dos primeiros círculos de cultura em Brasília, bem como de reuniões das autoridades, de âmbito federal, responsáveis pelo PNA, além de documentos textuais relacionados ao objeto investigado. A riqueza de dados encontrados sobre Paulo Freire demonstra a importância de sua passagem pela nova capital e o caráter emancipador do projeto de alfabetização. A abrupta interrupção da experiência, pelo golpe de 1964, impediu a continuidade das políticas públicas de alfabetização de adultos em curso no Brasil e impôs o apagamento da presença do educador na capital do País durante a Ditadura Militar. primórdios 1963 PNA , (PNA) Goulart documental historiográfico Dossiê Freire” Federal autoridades federal investigado 1964 Militar 196 (PNA 19 1