Compared to other species, components of Combretum lanceolatum are still with few data reported in the literature. This work describes the compounds identification, antioxidant and antimicrobial activities of C. lanceolatum twigs. Ethanolic extract (EECLT) from C. lanceolatum twigs was submitted to partition obtaining: hexane (HF), diethyl ether (EEF), ethyl acetate (EAF) and hydromethanolic (HMF) fractions. They were analyzed by gas chromatography-mass spectrometry, high performance liquid chromatography coupled to mass spectrometry and direct insertion mass spectrometry and evaluated for antioxidant assay (2,2-diphenyl-1-picrylhydrazyl (DPPH) method) and antimicrobial assay. Fifty-seven compounds were identified in the fractions. In antioxidant assay, EECLT and EAF demonstrated good antioxidant potential (half maximal effective concentration (EC50): 57.9 and 45.4 µg mL–1, respectively), better than the positive control butylated hydroxytoluene (BHT) (EC50: 69.34 µg mL–1). For antimicrobial assay, all fractions presented promising minimal inhibitory concentration (MIC). EECLT presented the best values against Staphylococcus aureus (125 µg mL–1) and Escherichia coli (62.5 µg mL–1) and better than the positive control fluconazole (8 and 16 µg mL–1) against Candida albicans (3.9 µg mL–1) and Candida krusei (15.6 µg mL–1) strains. This study presents relevant chemical and biological information about C. lanceloatum expanding the knowledge of Brazilian flora. species literature identification C (EECLT obtaining HF, HF , (HF) EEF, EEF (EEF) (EAF HMF (HMF chromatographymass 2,2diphenyl1picrylhydrazyl 22diphenyl1picrylhydrazyl diphenylpicrylhydrazyl 2,2 diphenyl 1 picrylhydrazyl 2 DPPH (DPPH method Fiftyseven Fifty seven half EC50 EC (EC50) 579 57 9 57. 454 45 4 45. mL1 mL mL–1 respectively, respectively respectively) BHT (BHT (EC50 6934 69 34 69.3 mL–1. . MIC. MIC (MIC) 125 (12 62.5 625 62 5 (62. 8 ( 3.9 39 3 (3. 15.6 156 15 6 (15. strains flora (HF (EEF 2diphenyl1picrylhydrazyl 22 2, EC5 mL– (EC5 693 69. (MIC 12 (1 62. (62 3. (3 15. (15 (EC (6

ABSTRACT Optic neuritis is an important cause of unilateral and acute visual loss in young adults, but other differential diagnoses should be considered, especially when the disease has an atypical presentation. This report presents the case of a young woman with reduced visual acuity in her right eye, associated with optic disc edema and a relative afferent pupillary defect, that was initially misdiagnosed as optic neuritis and subsequently found to have paracentral acute middle maculopathy, possibly secondary to subtle impending central retinal vein occlusion. This case emphasizes the need to remember that retinal vascular diseases can occasionally mimic optic neuritis. Detailed anamnesis and ophthalmic examination can avoid unnecessary interventions. adults considered presentation eye defect maculopathy occlusion interventions

RESUMO Este relato de caso apresenta um paciente feminino de 33 anos encaminhado para um serviço especializado de retina devido à leve perda de visão em olho direito. A acuidade visual foi de 20/25 no olho direito e 20/50 no olho esquerdo, o equivalente esférico foi de -12,75 dioptrias e -14,75 dioptrias, respectivamente. Avaliações multimodais revelaram isquese peripapilar nas camadas internas e externas da retina, descolamento vítreo posterior grau II e fundo tesselado. Avaliação funcional com perimetria Humphrey e microperimetria MP-3 revelaram sensibilidade macular normais e diminuição da sensibilidade na região peripapilar, especialmente no olho direito. Potencial visual evocado de padrão reverso apresentou no olho direito latência e amplitude N75 e P100 dentro dos valores normais para verificação de 1º. Entretanto, a amplitude foi baixa para a de 15′. Pacientes alto míopes com esfiloma posterior envolvendo o nervo óptico são suscetíveis à tração da hialoide posterior. Portanto a tração vitreopapilar resultante pode causar comprometimento da visão. 3 2025 20 25 20/2 2050 50 20/5 esquerdo 12,75 1275 12 75 -12,7 14,75 1475 14 -14,7 respectivamente tesselado MP3 MP MP- N N7 P P10 1º º Entretanto 15 15′ 202 2 20/ 205 5 12,7 127 1 7 -12, 14,7 147 -14, P1 12, -12 14, -14 -1 -

ABSTRACT This case report presents the details of a 33-year-old female patient who was referred to a specialized retina service because of mild vision loss in her right eye). The patient’s visual acuity was 20/25 in right eye and 20/50 in the left eye (; amblyopic); the spherical equivalent was -12.75 diopters (right eye) and -14.75 diopters (left eye). Multimodal retinal imaging showed peripapillary schisis in both the inner and outer retinal layers, grade II posterior vitreous detachment, and a tessellated fundus. Using Humphrey perimetry and MP-3 microperimetry, the functional evaluation indicated macular sensitivity within normal limits and decreased sensitivity in the peripapillary region, especially in right eye. The pattern-re versal visual evoked potential was measured. The N75 and P100 latency and amplitude in right eye were within normal values for checks of 1º. However, the amplitude was low for checks of 15′. Highly myopic patients who have posterior staphyloma that involves the optic nerve are susceptible to posterior hyaloid traction, and the resulting peripapillary vitreous traction may compromise vision. 33yearold yearold 33 year old . s 2025 20 25 20/2 2050 50 20/5 ( amblyopic amblyopic) 12.75 1275 12 75 -12.7 14.75 1475 14 -14.7 layers detachment fundus MP3 MP 3 MP- microperimetry region patternre pattern re measured N N7 P P10 1º º However 15 15′ 202 2 20/ 205 5 12.7 127 1 7 -12. 14.7 147 -14. P1 12. -12 14. -14 -1 -

RESUMO: A pesquisa foi conduzida para testar a hipótese de que a inclusão de casca de café (Coffea sp.) melhoraria as características fermentativas e a qualidade da silagem de milheto (Pennisetum glaucum). Assim, objetivou-se avaliar o efeito da inclusão de diferentes níveis da casca de café na ensilagem de milheto sobre a composição química, características fermentativas e degradabilidade in situ da silagem. O delineamento experimental utilizado foi inteiramente casualizado e os tratamentos constituíram-se pela silagem da planta inteira de milheto com a inclusão de níveis crescentes de casca de café: 0%, 7%, 14% e 21%, com base na matéria natural. Após 60 dias de fermentação, as silagens foram avaliadas quanto às características químicas, fermentativas, degradabilidade in situ da matéria seca (MS) e da fibra em detergente neutro (FDN). A inclusão da casca de café não alterou (P > 0,05) os teores de proteína bruta (11,94%), FDN (44,89%) e nutrientes digestíveis totais (65,09%). Houve aumentos nas concentrações de MS e fibra em detergente ácido, acompanhados de uma redução nas concentrações de matéria mineral e extrato etéreo, à medida que se aumentou a participação da casca de café nas silagens. Houve um aumento no teor de lignina até o nível de 7,59% de inclusão da casca de café. Não houve efeito da inclusão da casca de café sobre o pH da silagem (3,60). Entretanto, a inclusão de casca de café acarretou na redução da temperatura, perdas por gases, degradabilidade in situ da MS e FDN da silagem. Recomenda-se a inclusão de casca de café até o nível de 14,0% da matéria natural para melhoria do padrão de fermentação e da qualidade da silagem de milheto. RESUMO Coffea sp. sp Pennisetum glaucum. glaucum . glaucum) Assim objetivouse objetivou química constituíramse constituíram 0 0% 7 7% 14 21 21% 6 químicas (MS FDN. (FDN) P 0,05 005 05 11,94%, 1194 11,94% , 11 94 (11,94%) 44,89% 4489 44 89 (44,89% 65,09%. 6509 65,09% 65 09 (65,09%) ácido etéreo 759 59 7,59 3,60. 360 3,60 3 (3,60) Entretanto temperatura gases Recomendase Recomenda 140 14,0 1 2 (FDN 0,0 00 119 11,94 9 (11,94% 44,89 448 4 8 (44,89 650 65,09 (65,09% 75 5 7,5 36 3,6 (3,60 14, 0, 11,9 (11,94 44,8 (44,8 65,0 (65,09 7, 3, (3,6 11, (11,9 44, (44, 65, (65,0 (3, (11, (44 (65, (3 (11 (4 (65 ( (1 (6

ABSTRACT: The research was conducted to test the hypothesis that the inclusion of coffee husk (Coffea sp.) would improve the fermentative characteristics and quality of pearl millet silage (Pennisetumglaucum). Thus, the objective was to assess the effect of the inclusion of different levels of coffee husk in pearl millet silage on the chemical composition, fermentative characteristics and degradability in situ of silage. The experimental design used was completely randomized and the treatments consisted of the silage of the whole pearl millet plant with the inclusion of increasing levels of coffee husk: 0%, 7%, 14% and 21%, based on natural matter. After 60 days of fermentation, the silages were evaluated for chemical characteristics, fermentative, degradability in situ dry matter (DM) and neutral detergent fiber (NDF). The inclusion of coffee husk did not alter (P > 0.05) the contents of crude protein (11.94%), NDF (44.89%) and total digestible nutrients (65.09%). There were increases in the concentrations of DM and fiber in acid detergent, accompanied by a reduction in the concentrations of mineral matter and ether extract, as the proportion of coffee husks in silages increased. There was an increase in the lignin content up to the level of 7.59% inclusion of the coffee husk. There was no effect of the inclusion of the coffee husk on the pH of the silage (3.60). However, the inclusion of coffee husk resulted in a reduction in temperature, gas losses, and degradability in situ of silage DM and NDF. It is recommended to include coffee husk up to the level of 14.0% of the natural matter to improve the fermentation pattern and the quality of the pearl millet silage. ABSTRACT Coffea sp. sp Pennisetumglaucum. Pennisetumglaucum . (Pennisetumglaucum) Thus composition 0 0% 7 7% 14 21 21% 6 (DM (NDF) P 0.05 005 05 11.94%, 1194 11.94% , 11 94 (11.94%) 44.89% 4489 44 89 (44.89% 65.09%. 6509 65.09% 65 09 (65.09%) extract increased 759 59 7.59 3.60. 360 3.60 3 (3.60) However temperature losses 140 14.0 (Pennisetumglaucum 1 2 (NDF 0.0 00 119 11.94 9 (11.94% 44.89 448 4 8 (44.89 650 65.09 (65.09% 75 5 7.5 36 3.6 (3.60 14. 0. 11.9 (11.94 44.8 (44.8 65.0 (65.09 7. 3. (3.6 11. (11.9 44. (44. 65. (65.0 (3. (11. (44 (65. (3 (11 (4 (65 ( (1 (6

RESUMO Introdução: A negativa familiar para autorização da doação de órgãos e tecidos humanos mantém-se elevada ao longo dos anos. Dentre as muitas causas de não efetivação da doação, destacam-se a falta de informação sobre o processo e o desconhecimento da família sobre o desejo do doador em vida, além de outras questões, como a aparência do corpo do doador após a captação. Nesse sentido, torna-se necessário trazer à luz da discussão os aspectos que permeiam os conceitos de morte, dignidade humana e zelo pela imagem do doador, principalmente no caso de doadores de tecidos, nos quais a retirada pode apresentar-se mais perceptível. Objetivos: Realizou-se uma revisão integrativa da literatura (RI), buscando evidenciar lacunas e caracterizar o processo da doação de órgãos e tecidos humanos, com foco na reconstrução do corpo do doador e na dignidade humana. Em complemento, também se propôs descrever um relato de experiência de um profissional de um banco de tecidos humanos (BTH). Métodos: Por meio da estratégia PICO, elaborou-se a questão norteadora do estudo, após a RI realizada nos últimos 10 anos, operacionalizada por descritores controlados nas bases de dados SciELO, LILACS, Google Acadêmico e PubMed. Adicionado à busca, foi descrito um relato de experiência referente às técnicas de reconstrução do corpo do doador após a captação dos tecidos utilizados por um BTH localizado no interior do estado de São Paulo. Resultados: Foram encontrados nove estudos específicos sobre doação e utilização de próteses para reconstrução de áreas doadas. Os resultados demonstram os motivos que envolvem a recusa familiar, assim como o cuidado que as equipes técnicas têm na reconstituição do corpo dos doadores. A preocupação da família em relação à situação estética do doador influencia a aceitação para doação, portanto, torna-se necessário investir na seguridade e na qualidade dos serviços prestados pelos BTH, a fim de diminuir a recusa familiar para doação. Conclusão: A comunicação clara e a seguridade dos processos que envolvem a captação de órgãos e tecidos humanos mostraram-se o melhor caminho para facilitar a doação, podendo, assim, aumentar as doações. Introdução mantémse mantém anos destacamse destacam vida questões sentido tornase torna morte apresentarse apresentar perceptível Objetivos Realizouse Realizou RI, , (RI) complemento BTH. . (BTH) Métodos PICO elaborouse elaborou estudo 1 SciELO LILACS PubMed busca Paulo Resultados doadas portanto Conclusão mostraramse mostraram podendo doações (RI (BTH

ABSTRACT Introduction: Family refusal to authorize the donation of human organs and tissues has remained high over the years. Among the many reasons for not donating, we highlight the lack of information about the process and the family’s lack of knowledge about the donor’s wishes in life, as well as other issues, such as the appearance of the donor’s body after donation. In this sense, it is necessary to bring to light the aspects that permeate the concepts of death, human dignity, and care for the donor’s image, especially in the case of tissue donors, where the removal may be more noticeable. Objectives: An integrative literature review (ILR) was carried out, seeking to highlight gaps and characterize the process of donating human organs and tissues, with a focus on the reconstruction of the donor’s body and human dignity. In addition, the aim was to describe the experience of a professional from a human tissue bank (BTH). Methods: Using the PICO strategy, the study’s guiding question was drawn up following an IR carried out over the last 10 years, operationalized by controlled descriptors in the SciELO, LILACS, Google Scholar, and PubMed databases. In addition to the search, an experience report was described on the techniques used to reconstruct the donor’s body after the tissues used by a BTH located in the interior of the state of São Paulo were harvested. Results: Nine specific studies were found on donation and the use of prostheses to reconstruct donated areas. The results show the reasons for family refusal, as well as the care taken by the technical teams in reconstructing donors’ bodies. The family’s concern about the donor’s aesthetic situation influences acceptance for donation, so it is necessary to invest in the safety and quality of the services provided by BTH to reduce family refusal for donation. Conclusion: Clear communication and the safety of the processes involved in the procurement of human organs and tissues proved to be the best way to facilitate donation and could thus increase donations. Introduction years familys s donors donor life issues sense death dignity image noticeable Objectives ILR (ILR BTH. . (BTH) Methods strategy studys study 1 SciELO LILACS Scholar databases search harvested Results areas bodies Conclusion donations (BTH

RESUMO Objetivos: A microperimetria tem sido usada há vários anos como uma forma de teste de função visual em pacientes com doenças da retina. Os valores normais de microperimetria obtidos com MP-3 ainda não foram totalmente publicados e os valores basais para sensibilidade macular topográfica e correlações com idade e sexo são necessários para estabelecer graus de comprometimento. O objetivo do trabalho é determinar valores para limiares de sensibilidade à luz e estabilidade de fixação usando o MP-3 em indivíduos normais. Métodos: Trinta e sete voluntários saudáveis (idade: 28-68 anos), submetidos à microperimetria de limiar total usando uma estratégia de escada 4-2 (rápida) com o tamanho de estímulo padrão Goldmann III e 68 pontos de teste posicionados de forma idêntica aos do Humphrey Field Analyzer 10-2 grade de teste. A estabilidade da fixação foi registrada simultaneamente durante o teste de microperimetria. A relação entre a sensibilidade global e a idade foi calculada por meio de análise de regressão linear. Resultados: A microperimetria foi realizada em 37 indivíduos (74 olhos). A sensibilidade média global foi de 29,01 ± 1,44 dB, intervalo: 26-31 dB. A mediana da sensibilidade central a 2° medida pelo MP-3 foi de 28,5 ± 1,77 dB (ER) e 28,75 ± 1,98 dB (OE). Os valores médios totais de estabilidade da fixação em 2° e 4° foram 80% e 96%, respectivamente. A análise de regressão linear também revelou um declínio de sensibilidade global relacionado à idade por ano de -0,051 dB ± 0,018 (ER) e -0,078 dB ± 0,021 (LE). Conclusões: A microperimetria realizada com o MP-3 permite um exame automático, preciso e específico da topografia dos limiares de sensibilidade da retina. Os resultados deste estudo fornecem um banco de dados normal e de idade correspondente da microperimetria MP-3. Objetivos retina MP3 MP 3 MP- comprometimento Métodos (idade 2868 28 28-6 anos, , anos) 42 4 2 4- rápida (rápida 6 102 10 10- Resultados 74 (7 olhos. olhos . olhos) 2901 29 01 29,0 144 1 44 1,4 intervalo 2631 26 31 26-3 285 5 28, 177 77 1,7 ER (ER 2875 75 28,7 198 98 1,9 OE. OE (OE) 80 96 96% respectivamente 0,051 0051 0 051 -0,05 0018 018 0,01 0,078 0078 078 -0,07 0021 021 0,02 LE. LE (LE) Conclusões automático MP3. 3. 286 28- 7 ( 290 29, 14 1, 263 26- 17 287 19 9 (OE 8 0,05 005 05 -0,0 001 0,0 0,07 007 07 002 02 (LE 00 -0, 0, -0 -

ABSTRACT Purpose: Microperimetry has been used for several years as a form of visual function testing in patients with retinal diseases. Normal microperimetry values obtained with microperimeter MP-3 have not yet been fully published, and baseline values for topographic macular sensitivity and correlations with age and sex are needed to establish degrees of impairment. This study aimed to determine values for light sensitivity thresholds and fixation stability using the MP-3 in healthy individuals. Methods: Thirty-seven healthy volunteers (age, 28-68 years), underwent full-threshold microperimetry using a 4-2 (fast) staircase strategy with the standard Goldmann III stimulus size and 68 test points positioned identically to those in the Humphrey Field Analyzer 10-2 test grid. The fixation stability was simultaneously recorded during the microperimetry test. The relationship between global sensitivity and age was calculated using linear regression analysis. Results: Microperimetry was performed on 37 participants (74 eyes). The global mean sensitivity was 29.01 ± 1.44 (range, 26-31) dB. The mean central sensitivity at 2° measured by the MP-3 was 28.5 ± 1.77 dB in the right eye (OD) and 28.75 ± 1.98 dB in the left eye (OS). The total median fixation stability values within 2° and 4° were 80% and 96%, respectively. The linear regression analysis also revealed an age-related global sensitivity decline per year of -0.051 dB ± 0.018 (OD) and -0.078 dB ± 0.021 (OS). Conclusions: Microperimetry performed with the MP-3 allows for an automatic, accurate, and topography-specific examination of retinal sensitivity thresholds. The results of this study provide a normal and age-matched database of MP-3 microperimetry. Purpose diseases MP3 MP 3 MP- published impairment individuals Methods Thirtyseven Thirty seven age, (age 2868 28 28-6 years, , years) fullthreshold full threshold 42 4 2 4- fast (fast 6 102 10 10- grid Results 74 (7 eyes. eyes . eyes) 2901 29 01 29.0 144 1 44 1.4 range, range (range 2631 26 31 26-31 285 5 28. 177 77 1.7 OD (OD 2875 75 28.7 198 98 1.9 OS. OS (OS) 80 96 96% respectively agerelated related 0.051 0051 0 051 -0.05 0018 018 0.01 0.078 0078 078 -0.07 0021 021 0.02 Conclusions automatic accurate topographyspecific topography specific agematched matched 286 28- 7 ( 290 29. 14 1. 263 26-3 17 287 19 9 (OS 8 0.05 005 05 -0.0 001 0.0 0.07 007 07 002 02 26- 00 -0. 0. -0 -

ABSTRACT Objective: To understand the susceptibility to single nucleotide polymorphisms in the promoter region of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) in patients with and without periodontal disease. Thus, a systematic review of available studies on the subject was performed. Material and Methods: A protocol was conducted for registration in the International Prospective Register of Systematic Reviews (PROSPERO) under CRD42021246646. For this search, studies were selected from the Scopus, Web of Science, Virtual Health Library, Embase, Cochrane Library, and PubMed databases. The selection criteria consisted of case-control and cohort studies published in English that had data on IL-4 and IL-13 genetic polymorphisms in patients with and without periodontal disease in the same study. The obtained studies were managed by EndNote Program™ X7 version and the Rayyan Platform. Regarding the risk of bias, we used the Newcastle-Ottawa Scale, which classified the studies using high-quality methodology. Results: After the selection process, three studies presented the eligibility criteria. No relation between IL-13 and susceptibility to periodontal disease was found. IL-4 gene (IL-4 -590C/T; IL-4-34C/T; rs2243248) was associated with susceptibility to the development of periodontitis. Conclusion: An association between IL-4 and the susceptibility of periodontitis was verified. Further case-control studies are needed to create more concrete conclusions on the subject. Objective Interleukin4 Interleukin 4 Interleukin- IL4 IL Interleukin13 13 Interleukin-1 IL13 (IL-13 Thus performed Methods PROSPERO (PROSPERO CRD42021246646 CRD search Scopus Science Library Embase databases casecontrol case control IL- IL-1 study Program X Platform bias NewcastleOttawa Newcastle Ottawa Scale highquality high quality methodology Results process found (IL- 590C/T 590CT CT 590C T C -590C/T IL434C/T IL434CT ILCT 34C/T 34C IL-4-34C/T rs2243248 rs Conclusion verified Interleukin1 1 IL1 (IL-1 CRD4202124664 (IL IL434C 34CT rs224324 CRD420212466 ILC rs22432 CRD42021246 rs2243 CRD4202124 rs224 CRD420212 rs22 CRD42021 rs2 CRD4202 CRD420 CRD42 CRD4

Resumo A multimorbidade, presença de duas ou mais doenças crônicas não transmissíveis, está diretamente associada a fatores comportamentais. O objetivo da pesquisa foi estimar a prevalência de multimorbidade em jovens brasileiros relacionando-a aos diferentes determinantes sociais e de estilo de vida. Trata-se de um estudo transversal cuja fonte de dados foi a Pesquisa Nacional de Saúde em 2019. Foram selecionados dados de indivíduos com idade entre 15 e 24 anos (n = 10.460). Os fatores associados foram investigados por meio do cálculo da razão de prevalência com variância robusta, adequado para análise bivariada e multivariada. A prevalência de multimorbidade nos jovens foi estimada em 7,84% (IC95%: 7,01-8,75; N: 2.455.097). Os agravos mais comuns foram doenças mentais, depressão, asma ou bronquite e problemas crônicos de coluna. No modelo ajustado, jovens do sexo feminino (RP: 1,84; IC95%: 1,44-2,36), obesos (RP: 1,97; IC95%: 1,45-2,68) e ex-fumantes (RP: 1,46; IC95%: 1,12-1,90) apresentaram maiores prevalências para multimorbidade. A razão de prevalência para multimorbidade aumentou 5% a cada ano de vida do indivíduo. Este estudo identificou uma associação de multimorbidade com determinantes sociais e estilo de vida. transmissíveis comportamentais relacionandoa relacionando Tratase Trata se 2019 1 2 n 10.460. 10460 10.460 . 10 460 10.460) robusta multivariada 784 7 84 7,84 IC95% IC95 IC (IC95% 7,018,75 701875 7,01 8,75 01 8 75 7,01-8,75 N 2.455.097. 2455097 2.455.097 455 097 2.455.097) mentais depressão coluna ajustado RP (RP 1,84 184 1,442,36, 144236 1,44 2,36 , 44 36 1,44-2,36) 1,97 197 97 1,452,68 145268 1,45 2,68 45 68 1,45-2,68 exfumantes ex fumantes 1,46 146 46 1,121,90 112190 1,12 1,90 12 90 1,12-1,90 5 indivíduo 201 1046 10.46 78 7,8 IC9 (IC95 018 7,018,7 70187 701 7,0 875 8,7 0 7,01-8,7 245509 2.455.09 09 1,8 18 442 1,442,36 14423 144 1,4 236 2,3 4 3 1,44-2,36 1,9 19 9 452 1,452,6 14526 145 268 2,6 6 1,45-2,6 14 121 1,121,9 11219 112 1,1 190 1,12-1,9 20 104 10.4 7, (IC9 7,018, 7018 70 87 8, 7,01-8, 24550 2.455.0 1, 1,442,3 1442 23 2, 1,44-2,3 1,452, 1452 26 1,45-2, 1,121, 1121 11 1,12-1, 10. (IC 7,018 7,01-8 2455 2.455. 1,442, 1,44-2, 1,452 1,45-2 1,121 1,12-1 7,01- 245 2.455 1,442 1,44-2 1,45- 1,12- 2.45 1,44- 2.4 2.

Abstract Multimorbidity, namely the presence of two or more chronic non-communicable diseases, is directly associated with behavioral factors. This study sought to estimate the prevalence of multimorbidity among young Brazilians by linking it to different social and lifestyle determinants. It involved a cross-sectional study of the data source, namely the 2019 National Health Survey. Data from individuals aged between 15 and 24 years (n = 10,460) were selected. Associated factors were investigated by calculating the Prevalence Ratio with robust variance, suitable for bivariate and multivariate analysis. The prevalence of multimorbidity in young people was estimated at 7.84% (95%CI: 7.01-8.75; N: 2,455,097). The most common conditions were mental illness, depression, asthma or bronchitis and chronic back problems. In the adjusted model, young females (PR: 1.84; 95%CI: 1.44-2.36), obese youths (PR: 1.97; 95%CI: 1.45-2.68) and former smokers (PR: 1.46; 95%CI: 1.12-1.90) showed a higher prevalence of multimorbidity. It was also revealed that the prevalence ratio for multimorbidity increased by 5% for each year of the individual’s life. This study identified an association of multimorbidity with social determinants and lifestyle. Multimorbidity noncommunicable non communicable diseases crosssectional cross sectional source 201 Survey 1 2 n 10,460 10460 10 460 selected variance analysis 784 7 84 7.84 95%CI 95CI CI 95 (95%CI 7.018.75 701875 7.01 8.75 01 8 75 7.01-8.75 N 2,455,097. 2455097 2,455,097 . 455 097 2,455,097) illness depression problems model PR (PR 1.84 184 1.442.36, 144236 1.44 2.36 , 44 36 1.44-2.36) 1.97 197 97 1.452.68 145268 1.45 2.68 45 68 1.45-2.68 1.46 146 46 1.121.90 112190 1.12 1.90 12 90 1.12-1.90 5 individual s life 20 10,46 1046 78 7.8 9 018 7.018.7 70187 701 7.0 875 8.7 0 7.01-8.7 245509 2,455,09 09 1.8 18 442 1.442.36 14423 144 1.4 236 2.3 4 3 1.44-2.36 1.9 19 452 1.452.6 14526 145 268 2.6 6 1.45-2.6 14 121 1.121.9 11219 112 1.1 190 1.12-1.9 10,4 104 7. 7.018. 7018 70 87 8. 7.01-8. 24550 2,455,0 1. 1.442.3 1442 23 2. 1.44-2.3 1.452. 1452 26 1.45-2. 1.121. 1121 11 1.12-1. 10, 7.018 7.01-8 2455 2,455, 1.442. 1.44-2. 1.452 1.45-2 1.121 1.12-1 7.01- 245 2,455 1.442 1.44-2 1.45- 1.12- 2,45 1.44- 2,4 2,

Resumo A multimorbidade, presença de duas ou mais doenças crônicas não transmissíveis, está diretamente associada a fatores comportamentais. O objetivo da pesquisa foi estimar a prevalência de multimorbidade em jovens brasileiros relacionando-a aos diferentes determinantes sociais e de estilo de vida. Trata-se de um estudo transversal cuja fonte de dados foi a Pesquisa Nacional de Saúde em 2019. Foram selecionados dados de indivíduos com idade entre 15 e 24 anos (n = 10.460). Os fatores associados foram investigados por meio do cálculo da razão de prevalência com variância robusta, adequado para análise bivariada e multivariada. A prevalência de multimorbidade nos jovens foi estimada em 7,84% (IC95%: 7,01-8,75; N: 2.455.097). Os agravos mais comuns foram doenças mentais, depressão, asma ou bronquite e problemas crônicos de coluna. No modelo ajustado, jovens do sexo feminino (RP: 1,84; IC95%: 1,44-2,36), obesos (RP: 1,97; IC95%: 1,45-2,68) e ex-fumantes (RP: 1,46; IC95%: 1,12-1,90) apresentaram maiores prevalências para multimorbidade. A razão de prevalência para multimorbidade aumentou 5% a cada ano de vida do indivíduo. Este estudo identificou uma associação de multimorbidade com determinantes sociais e estilo de vida.

Abstract Multimorbidity, namely the presence of two or more chronic non-communicable diseases, is directly associated with behavioral factors. This study sought to estimate the prevalence of multimorbidity among young Brazilians by linking it to different social and lifestyle determinants. It involved a cross-sectional study of the data source, namely the 2019 National Health Survey. Data from individuals aged between 15 and 24 years (n = 10,460) were selected. Associated factors were investigated by calculating the Prevalence Ratio with robust variance, suitable for bivariate and multivariate analysis. The prevalence of multimorbidity in young people was estimated at 7.84% (95%CI: 7.01-8.75; N: 2,455,097). The most common conditions were mental illness, depression, asthma or bronchitis and chronic back problems. In the adjusted model, young females (PR: 1.84; 95%CI: 1.44-2.36), obese youths (PR: 1.97; 95%CI: 1.45-2.68) and former smokers (PR: 1.46; 95%CI: 1.12-1.90) showed a higher prevalence of multimorbidity. It was also revealed that the prevalence ratio for multimorbidity increased by 5% for each year of the individual’s life. This study identified an association of multimorbidity with social determinants and lifestyle.

RESUMO O objetivo desse estudo foi comparar os efeitos do treinamento funcional (TF) orientado à velocidade (VOTF) e orientado à força (SOTF) em diferentes parâmetros de corrida de mudança de direção (COD), capacidade de salto e velocidade linear em jogadores de futebol sub-20. Para isso, 22 jogadores foram randomizados em dois grupos: VOFT e SOFT. Os participantes foram avaliados no momento pré e no momento pós-intervenção no teste de corrida em L para o lado direito (CODLD) e para o lado esquerdo (CODLE) para avaliar o COD veloz (≤ 90°) e no teste de ziguezague para avaliar o COD força (> 90°). Altura de salto foi aferida pelo salto com contramovimento (CMJ) e pelo salto de agachamento (SJ). A velocidade máxima foi avaliada pelo teste de sprint em 20 metros. O índice de déficit de mudança de direção (COD déficit) foi calculado para todos os testes de COD. Ambos os grupos apresentaram melhora significativa ao longo do tempo no CODLD, no ziguezague teste, no COD déficit de CODLD e no COD déficit do ziguezague. O teste de sprint em 20 metros, o CODLE e o COD déficit de CODLE não diferiram significativamente para nenhum grupo em nenhum momento. Apesar de não apresentar diferença estatisticamente significativa ao longo do tempo, o CMJ apresentou tamanho de efeito pequeno para o VOFT e SOFT. Enquanto o SJ apresentou tamanho de efeito moderado para o VOFT e pequeno para o SOFT. Além disso, não houve diferença significativa entre grupos para nenhuma variável. Portanto conclui-se que a aplicação de protocolos de TF orientados para velocidade ou força como forma complementar ao treinamento técnico tático, ao longo de quatro semanas, promove mudanças significativas em diferentes parâmetros de corrida COD em atletas de futebol sub-20.

ABSTRACT The aim of this study was to compare the effects of velocity-oriented (VOTF) and strength-oriented (SOTF) functional training (TF) on different parameters of running change of direction (COD), jumping ability and linear velocity in under-20 soccer players. For this, 22 players were randomly assigned to VOFT and SOFT groups. The participants were evaluated at the pre- and post-intervention moment in the L-running test to the right side (CODLD) and to the left side (CODLE) to evaluate the fast COD (≤ 90°) and in the zigzag test to evaluate the strength COD (> 90°). Jump height was measured by countermovement jump (CMJ) and squat jump (SJ). Maximum speed was assessed by the 20-meter sprint test. The change of direction deficit index (COD deficit) was calculated for all COD tests. Both groups showed significant improvement over time in CODLD, zigzag test, COD-deficit CODLD, and COD zigzag deficit. The 20-meter sprint test, CODLE, and COD-deficit CODLE did not differ significantly for either group at any time point. Despite not showing a statistically significant difference over time, CMJ had a small effect size for VOFT and SOFT. At the same time, the SJ showed a moderate effect size for VOFT and a small effect size for SOFT. Furthermore, there was no significant difference between groups for any variable. Therefore, it is concluded that the application of FT protocols oriented towards speed or strength as a complement to tactical technical training, over four weeks, promotes significant changes in different COD running parameters in under-20 soccer players.

Resumo O presente trabalho teve como objetivo analisar o efeito de diferentes concentrações de cianamida hidrogenada (0,00; 0,26; 0.52; 0.78; e 1,04%) associadas a 3% de óleo mineral sobre o desenvolvimento de gemas da macieira ‘Eva’, em região de clima tropical de altitude, no Estado de Minas Gerais. Foram avaliados o percentual de brotação, a frutificação efetiva, o número de frutos por planta e a fenologia da floração durante os ciclos produtivos de 2020 e 2021. Mesmo não sendo submetida a temperaturas inferiores a 7,2°C, a cultivar ‘Eva’ completou seu ciclo de produção em dois anos subsequentes. A aplicação de cianamida hidrogenada, combinada com óleo mineral, promoveu maior brotação e uniformidade de floração, além de antecipar o início da floração da cultivar ‘Eva’. 0,00 000 0 00 (0,00 0,26 026 26 0.52 052 52 0.78 078 78 1,04% 104 1 04 3 ‘Eva, Eva ‘Eva , altitude Gerais efetiva 202 2021 72C C 7 2 7,2°C subsequentes ‘Eva. . 0,0 (0,0 0,2 02 0.5 05 5 0.7 07 1,04 10 20 0, (0, 0. 1,0 (0 1, (

Abstract This study was carried aiming to evaluate different hydrogen cyanamide concentrations (0.00%; 0.26%; 0.52% 0.78% and 1.04%) associated with (3%) mineral oil on the bud growth of the ‘Eva’ apple tree in a high-altitude tropical climate region in the state of Minas Gerais. Sprouting percentage, fruit set: ratio between number of fruits and number of flowers (%), number of fruits per plant and flowering phenology were evaluated during the 2020 and 2021 production cycles. Even not being submitted to temperatures below 7.2°C, the ‘Eva ‘ cultivar completed its production cycle in two subsequent years. Hydrogen cyanamide application combined with mineral oil promoted increased budbreak and flowering uniformity, in addition to anticipating the beginning of flowering of the ‘Eva’ apple cultivar. 0.00% 000 0 00 (0.00% 0.26% 026 26 052 52 0.52 078 78 0.78 1.04% 104 1 04 3% 3 (3% Eva highaltitude high altitude Gerais percentage set %, % , (%) 202 cycles 72C C 7 2 7.2°C years uniformity 0.00 (0.00 0.26 02 05 5 0.5 07 0.7 1.04 10 (3 (% 20 0.0 (0.0 0.2 0. 1.0 ( (0. 1. (0

SUMMARY OBJECTIVE: COVID-19 has brought emerging public health emergency and new challenges. It configures a complex panorama that has been requiring a set of coordinated actions and has innovation as one of its pillars. In particular, the use of digital tools plays an important role. In this context, this study presents a screening algorithm that uses a machine learning model to assess the probability of a diagnosis of COVID-19 based on clinical data. METHODS: This algorithm was made available for free on an online platform. The project was developed in three phases. First, an machine learning risk model was developed. Second, a system was developed that would allow the user to enter patient data. Finally, this platform was used in teleconsultations carried out during the pandemic period. RESULTS: The number of accesses during the period was 4,722. A total of 126 assistances were carried out from March 23, 2020, to June 16, 2020, and 107 satisfaction survey returns were received. The response rate to the questionnaires was 84.92%, and the ratings obtained regarding the satisfaction level were higher than 4.8 (on a 0–5 scale). The Net Promoter Score was 94.4. CONCLUSION: To the best of our knowledge, this is the first online application of its kind that presents a probabilistic assessment of COVID-19 using machine learning models exclusively based on the symptoms and clinical characteristics of users. The level of satisfaction was high. The integration of machine learning tools in telemedicine practice has great potential. OBJECTIVE COVID19 COVID 19 COVID-1 challenges pillars particular role context data METHODS phases First Second Finally RESULTS 4722 4 722 4,722 12 23 2020 16 10 received 8492 84 92 84.92% 48 8 4. 05 0 5 0– scale. scale . scale) 944 94 94.4 CONCLUSION knowledge users high potential COVID1 1 COVID- 472 72 4,72 2 202 849 9 84.92 94. 47 7 4,7 20 84.9 4, 84.

ABSTRACT A study was undertaken comparing the water requirements of two common bean ( Phaseolus vulgaris L.) cultivars to generate specific recommendations aimed at optimizing water use. To accomplish this work, the agronomic performance, responsiveness to water and water productivity of these two common bean cultivars of determinate and indeterminate growth habits were identified. The 2-year experiment was carried out during the winter growing season in the southeast of Brazil. Cultivars IAC Imperador, with an early season of determinate growth habit, and IPR Campos Gerais, having a mid-season of indeterminate growth habit, were subjected to five irrigation levels (54, 70, 77, 100, and 132 % of the crop evapotranspiration). Water deficit affected agronomic performance, reducing plant height (by up to 29 %), leaf area index (by up to 40 %), soil cover fraction (by up to 28 %), and grain yield (GY - by up to 31 %), in both cultivars. In contrast, excess water was more detrimental to cultivar IAC Imperador. Cultivar IPR Campos Gerais produced 18 % more than GY, showing superior water productivity and response to irrigation depth than IAC Imperador. Out of all the variables evaluated, the soil cover fraction correlated the most with grain yield in both common bean cultivars during the 2-year study. In other words, cover fraction evaluation in common bean allows for estimating crop production potential, which helps producers and technicians in their decision making regarding management practices. Thus, a cultivar directly affects water use in common bean production, thereby suggesting the need for a or water conservation strategy and sustainability of irrigated common bean production. L. L work performance identified 2year year 2 Brazil Imperador habit midseason mid 54, 54 (54 70 77 100 13 evapotranspiration. evapotranspiration . evapotranspiration) %, , %) 4 GY 3 contrast 1 evaluated words potential practices Thus 5 (5 7 10

RESUMO Esta é uma série de casos sobre macroaneurismas arteriais da retina em três pacientes recuperados da COVID-19. Nenhum tinha história ocular e sistêmica prévias. O primeiro era um homem de 47 anos, com melhor acuidade visual corrigida de 20/20 em ambos os olhos. Apresentava mancha algodonosa em olho direito e dois macroaneurismas arteriais da retina exsudativos periféricos em olho esquerdo. Foi realizada fotocoagulação a laser, e a melhor acuidade visual corrigida permaneceu estável. A segunda era uma mulher de 62 anos com perda visual aguda em olho direito (melhor acuidade visual corrigida de 20/400). Havia hemorragia vítrea e um macroaneurisma periférico em olho direito. O laser foi realizado, e a melhor acuidade visual corrigida melhorou para 20/20. A terceira paciente era uma mulher de 54 anos, com melhor acuidade visual corrigida 20/20 em olho direito e 20/600 olho esquerdo. A fundoscopia mostrou hemorragia em múltiplas camadas na região macular e um macroaneurisma arterial da retina no ramo temporal superior. Os casos foram submetidos à angiofluoresceinografia, que confirmou o diagnóstico de macroaneurismas arteriais da retina. COVID19. COVID19 COVID 19. 19 COVID-19 prévias 4 2020 20 20/2 olhos esquerdo estável 6 20/400. 20400 20/400 . 400 20/400) realizado 5 20600 600 20/60 superior angiofluoresceinografia COVID1 1 COVID-1 202 2 20/ 2040 20/40 40 2060 60 20/6 COVID- 204 20/4 206

ABSTRACT This is a case series about retinal arterial macroaneurysms in three patients recovered from COVID-19. None of them had previous past ocular and systemic history. The first patient was a 47-year-old man, with best-corrected visual acuity of 20/20 in both eyes. He presented a cotton wool spot in the right eye and two peripheral exudative retinal arterial macroaneurysms in the left eye. Laser photocoagulation was performed and best-corrected visual acuity remained stable. The second one was a 62-year-old-woman with acute visual loss in the right eye (best-corrected visual acuity of 20/400). There was vitreous hemorrhage and a peripheral retinal arterial macroaneurysm in the right eye. Laser photocoagulation was performed and best-corrected visual acuity improved to 20/20. The third patient was a 54-year-old woman, with best-corrected visual acuity of 20/20 in the right eye and 20/600 in the left eye. Fundus examination showed multiple layer hemorrhage in the macular region and retinal arterial macroaneurysms in the superior temporal branch. The cases underwent fluorescein angiography, which confirmed the diagnosis of retinal arterial macroaneurysms. COVID19. COVID19 COVID 19. 19 COVID-19 history 47yearold yearold 47 year old man bestcorrected best corrected 2020 20 20/2 eyes stable 62yearoldwoman yearoldwoman 62 woman 20/400. 20400 20/400 . 400 20/400) 54yearold 54 20600 600 20/60 branch angiography COVID1 1 COVID-1 4 202 2 20/ 6 2040 20/40 40 5 2060 60 20/6 COVID- 204 20/4 206