Resumo Este artigo objetivou analisar recomendações para educação em saúde de gestantes e puérperas em tempos de pandemia de Covid-19. Trata-se de uma revisão integrativa que ocorreu no período setembro de 2021 a fevereiro de 2022, nas bases de dados MEDLINE via PubMed, Literatura Latino-Americana e do Caribe em Ciências da Saúde, Scientific Electronic Library Online e na Biblioteca Virtual em Saúde. Utilizou-se o software online Endnote Web para armazenar as referências obtidas na busca e retirar duplicações. A amostra final foi composta por 17 estudos. Após análise, os achados foram distribuídos em duas categorias: educação em saúde para assistência pré-natal de gestantes e educação em saúde para bem-estar físico e mental de gestantes e puérperas. O estudo mostrou que as recomendações para gestantes e puérperas, no cenário pandêmico, tem ênfase na educação em saúde associada a ferramentas tecnológicas durante todo o processo gravídico-puerperal, baseadas em informações e estratégias que favoreçam a promoção da saúde e a prevenção de agravos.

Abstract This article aimed to analyze recommendations for health education for pregnant and postpartum women in times of the Covid-19 pandemic. This is an integrative review that took place from September 2021 to February 2022, in the MEDLINE databases via PubMed, Latin American and Caribbean Health Sciences Literature, Scientific Electronic Library Online and the Virtual Health Library. The online software Endnote Web was used to store the references obtained in the search and to remove duplications. The final sample consisted of 17 studies. After analysis, the findings were divided into two categories: health education for prenatal care of pregnant women and health education for the physical and mental well-being of pregnant and postpartum women. The study showed that the recommendations for pregnant and puerperal women, in the pandemic scenario, emphasize health education associated with technological tools throughout the pregnancy-puerperal process, based on information and strategies that favor health promotion and disease prevention.

RESUMO Objetivo Analisar fatores associados à viremia detectável de HIV entre mulheres transexuais/travestis (MTTr), em cinco capitais brasileiras. Métodos Dados referentes à amostra de MTTr com sorologia reagente para HIV e carga viral (CV) detectável, em um estudo transversal entre 2019 e 2021. As variáveis dependentes e independentes foram, respectivamente: dosagem da carga viral, características socioeconômicas/demográficas; uso de álcool/drogas; e autopercepção de saúde mental. Foi utilizada a regressão de Poisson com variância robusta. Resultados Um total de 425 MTTr tiveram resultado reagente para HIV e realizaram dosagem de CV, com 179 (42,0%) detectáveis. Os fatores associados positivamente à detectabilidade foram: serem mais novas (RP=2,26; IC95% 1,13;4,51), piores condições de moradia (RP=2,72; IC95% 1,30;5,68) e saúde mental ruim/muito ruim (RP=1,70; IC95% 1,08;2,66). O uso de antirretroviral foi fator protetor à detectabilidade (RP=0,29; IC95% 0,30;0,61). Conclusão Os fatores associados à não supressão viral apontam vulnerabilidade ligada à identidade de gênero com impacto negativo, mesmo com a maioria em uso da terapia antirretroviral (TARV).

ABSTRACT Objective To analyze factors associated with detectable HIV viremia among transgender women/transvestites (TWT) in five Brazilian capitals. Methods : This was a cross-sectional study using data from a sample of TWT with HIV-positive serology and detectable viral load (VL), between 2019 and 2021. The dependent and independent variables were, respectively: viral load measurement, socioeconomic/demographic characteristics; alcohol/drug use; and self-perceived mental health. Poisson regression with robust variance was used. Results : A total of 425 TWT tested positive for HIV and underwent VL measurement, 179 (42.0%) presented detectable viremia. Factors positively associated with detectability were: younger age (PR=2.26; 95%CI 1.13;4.51), poorer housing conditions (PR=2.72; 95%CI 1.30;5.68) and poor/very poor mental health (PR=1.70; 95%CI 1.08;2.66). The use of antiretroviral drugs was a protective factor against detectability (PR=0.29; 95%CI 0.30;0.61). Conclusion The factors associated with unsuppressed viral load highlight vulnerability related to gender identity that have a negative impact, despite the majority of participants being on antiretroviral therapy (ART).

RESUMEN Objetivo Analizar factores asociados a la viremia detectable del VIH entre mujeres transexuales/travestis (MTTr), en cinco capitales brasileñas. Métodos Datos referentes al muestreo MTTr con serología reactiva para VIH y carga viral detectable (CV), en estudio transversal entre 2019-2021. Las variables dependientes e independientes fueron, respectivamente: medición de carga viral, socioeconómicas/demográficas; consumo de alcohol/drogas; y autopercepción de salud mental. Se utilizó la regresión de Poisson con varianza robusta. Resultados Un total de 425 MTTr dieron positivo para el VIH y se sometieron a pruebas CV, siendo 179 (42,0%) detectables. Los factores asociados positivamente con la detectabilidad fueron: ser más joven (RP=2,26; IC95% 1,13;4,51), peores condiciones de vivienda (RP=2,72; IC95% 1,30;5,68) y salud mental mala/muy mala (RP=1,70; IC95% 1,08;2,66). El uso de medicamentos antirretrovirales fue un factor protector para la detectabilidad (RP=0,29; IC95% 0,30;0,61). Conclusión Los factores asociados a la no supresión viral indican vulnerabilidad ligada a identidad de género con efecto negativo, incluso cuando la mayoría utiliza terapia antirretroviral (TARV).

RESUMO Objetivo: Estimar a prevalência de diagnóstico e internações hospitalares por COVID-19 e avaliar seus correlatos entre adultos no Brasil. Métodos: Um estudo transversal, com dados secundários do Inquérito Telefônico de Fatores de Risco para Doenças Crônicas não Transmissíveis em tempos de Pandemia — Covitel 2022 foi realizado. O estudo Covitel utiliza amostragem por conglomerados, realizada a partir de discagem aleatória de dígitos para linhas telefônicas fixas e celulares, entre pessoas de 18 anos ou mais. O desfecho “diagnóstico de COVID-19” foi baseado no autorrelato de um caso confirmado, por meio de exames laboratoriais ou diagnósticos médicos. Para aqueles que relataram COVID-19, foi questionado sobre a necessidade de internação hospitalar devido à COVID-19. As variáveis independentes incluíram sexo, idade, escolaridade, região, comorbidade, plano de saúde privado, autoavaliação de saúde e situação profissional. A razão de chances foi estimada por regressão logística considerando o desenho amostral complexo. Resultados: A partir da amostra de 9000 pessoas obteve-se prevalência de diagnóstico de COVID-19 de 25,4% (IC95% 23,8–27,1%), variando de 23,0% (IC95% 20,0–26,3%) na região Nordeste a 28,5% (IC95% 25,3–31,7%) na região Sul. Adultos entre 35–44 anos tiveram a maior prevalência de diagnóstico de COVID-19. Quanto maior a escolaridade, maior foi a prevalência do diagnóstico de COVID-19. Conclusão: A prevalência do diagnóstico de COVID-19 é marcadamente diferente daquela da infecção por SARS-CoV-2 a nível populacional. As diferenças socioeconômicas no acesso aos testes são a explicação provável. Idosos e pessoas com comorbidades tiveram maior probabilidade de serem internados em hospital devido à COVID-19 no Brasil.

ABSTRACT Objective: To estimate the prevalence of COVID-19 diagnosis and hospital admissions, and to evaluate their correlates in a nationwide Brazilian sample. Methods: A cross-sectional study was carried out with secondary data from the Telephone Survey of Risk Factors for Chronic Noncommunicable Diseases in Times of Pandemic – Covitel 2022. The Covitel study uses cluster sampling, carried out through random digit dialing on landlines and cell phones, among people aged 18 years or over. The outcome of the “diagnosis of COVID-19” was based on a self-report of a confirmed case through laboratory tests or medical diagnoses. Those who reported COVID-19 were asked about the need for hospital admission due to COVID-19. Independent variables included sex, age, level of education, region, comorbidity, private health insurance plan, self-rated health, and employment status. The odds ratio was estimated using logistic regression models considering the complex sample design. Results: From the sample of 9000 people, the prevalence of COVID-19 diagnosis was 25.4% (95%CI 23.8–27.1%), ranging from 23.0% (95%CI 20.0–26.3%) in the Northeast region to 28.5% (95%CI 25.3–31.7%) in the South region. Middle-aged adults (35–44 years old) had the highest prevalence of COVID-19 diagnosis. The higher the level of education, the higher the prevalence of COVID-19 diagnosis. Conclusion: The prevalence of COVID-19 diagnosis is markedly different from that of SARS-CoV-2 infection at the population level. Socioeconomic differences in access to testing are the likely explanation. Older adults and people with comorbidities were more likely to be admitted to hospital due to COVID-19 in Brazil.

Abstract Reproductive control is one of the biggest challenges in tilapia production and triploidy was developed as an alternative to sterilization. In general, polyploids present chromosomal instability but for triploid Nile tilapia it has yet to be reported. This study evaluated the chromosomal instability from juveniles to adulthood, growth performance and gonadal status of tilapia hatched from eggs submitted or not to heat shock for triploid induction. Nile tilapia oocytes were fertilized (1,476 oocytes), half of the eggs were subjected to a four-minute shock in 41 °C water four minutes after fertilization and the other half were not (Control group). The eggs were incubated (at 27°C) and 160 larvae from the treated group hatched and survived after yolk sac absorption. The determination of ploidy was performed by flow cytometry at 85th (juveniles) and 301st (adults) days of age post yolk sac absorption. At the time of the first cytometry analysis there were 73 surviving juveniles from the treated group, and only 14 were confirmed triploid. However, at the analysis of adult ploidy, one out of 8 surviving adult tilapias from the 14 confirmed triploid juveniles remained triploid. Gonadal histology showed that the non-remaining triploids continued to produce gametes. The growth performance of triploid tilapia was initially superior to that of diploid tilapia during the juvenile phase, but similar in adults. Once the chromosome sets are lost and the tilapias become diploid again, at least in tissues with a high proliferation rate, such as the hematopoietic tissue that was analyzed (and possibly in gonads), all possible advantages of triploids are probably lost. Thus, our results suggest that, due to genomic instabilities, the triploid generation of tilapia has low efficiency. sterilization general reported adulthood induction 1,476 1476 1 476 (1,47 oocytes, , oocytes) fourminute minute 4 C Control group. . group) 27°C 27C 27 16 absorption th (juveniles st adults (adults 7 However nonremaining non remaining gametes phase again rate gonads, gonads gonads) Thus instabilities efficiency 1,47 147 47 (1,4 2 1,4 (1, 1, (1 (

Resumo Este artigo objetivou analisar recomendações para educação em saúde de gestantes e puérperas em tempos de pandemia de Covid-19. Trata-se de uma revisão integrativa que ocorreu no período setembro de 2021 a fevereiro de 2022, nas bases de dados MEDLINE via PubMed, Literatura Latino-Americana e do Caribe em Ciências da Saúde, Scientific Electronic Library Online e na Biblioteca Virtual em Saúde. Utilizou-se o software online Endnote Web para armazenar as referências obtidas na busca e retirar duplicações. A amostra final foi composta por 17 estudos. Após análise, os achados foram distribuídos em duas categorias: educação em saúde para assistência pré-natal de gestantes e educação em saúde para bem-estar físico e mental de gestantes e puérperas. O estudo mostrou que as recomendações para gestantes e puérperas, no cenário pandêmico, tem ênfase na educação em saúde associada a ferramentas tecnológicas durante todo o processo gravídico-puerperal, baseadas em informações e estratégias que favoreçam a promoção da saúde e a prevenção de agravos. Covid19. Covid19 Covid 19. 19 Covid-19 Tratase Trata se 202 2022 PubMed LatinoAmericana Latino Americana Saúde Utilizouse Utilizou duplicações 1 estudos análise categorias prénatal pré natal bemestar bem estar pandêmico gravídicopuerperal, gravídicopuerperal gravídico puerperal, puerperal gravídico-puerperal agravos Covid1 Covid-1 20 Covid- 2

Abstract This article aimed to analyze recommendations for health education for pregnant and postpartum women in times of the Covid-19 pandemic. This is an integrative review that took place from September 2021 to February 2022, in the MEDLINE databases via PubMed, Latin American and Caribbean Health Sciences Literature, Scientific Electronic Library Online and the Virtual Health Library. The online software Endnote Web was used to store the references obtained in the search and to remove duplications. The final sample consisted of 17 studies. After analysis, the findings were divided into two categories: health education for prenatal care of pregnant women and health education for the physical and mental well-being of pregnant and postpartum women. The study showed that the recommendations for pregnant and puerperal women, in the pandemic scenario, emphasize health education associated with technological tools throughout the pregnancy-puerperal process, based on information and strategies that favor health promotion and disease prevention. Covid19 Covid 19 Covid-1 202 2022 PubMed Literature duplications 1 studies analysis categories wellbeing well being scenario pregnancypuerperal pregnancy process prevention Covid1 Covid- 20 2

Resumo Objetivo Nosso objetivo foi analisar as características limnológicas de riachos localizados em um município de turismo de luxo na Serra da Mantiqueira (Sudeste do Brasil). Métodos Nós analisamos variáveis físicas e químicas da água de seis pontos de coleta localizados em três riachos da bacia do rio Sapucaí-Guaçú ao longo da área urbana do município de Campos do Jordão e um ponto de coleta no Rio da Prata, como referência de local não impactado por poluição urbana (São Paulo, Brasil). Nós medimos algumas variáveis físicas e químicas da água e analisamos a concentração de nutrientes (formas de N e P) nos riachos próximos às nascentes da bacia (Pontos 1, 2 e 3), dentro e após a área urbana (Pontos 4 e 5), após a Estação de Tratamento de Esgoto (ETE) do município (Ponto 6) e no local de referência (Ponto 7). Para averiguar se houveram diferenças nas variáveis limnológicas entre os pontos de coleta utilizamos a Análise de Variância (ANOVA). Para ordenar os pontos de coleta de acordo com a variação de suas características limnológicas nós aplicamos uma Análise de Componentes Principais (PCA). Resultados Nossos resultados mostraram que os pontos 1, 2 e 3, embora próximos às nascentes, apresentaram alterações limnológicas em relação ao local de referência (Ponto 7) por causa das ocupações urbanas em seu entorno. Os pontos 4 e 6 são os mais poluídos devido à urbanização e ao lançamento de efluentes da ETE, respectivamente. O trecho entre estes dois locais (5) mostrou-se menos poluído devido ao processo de autodepuração. Conclusões Nós concluímos que os riachos da bacia do rio Sapucaí-Guaçú estão poluídos, embora em diferentes níveis. A área urbana de Campos do Jordão causa a poluição dos riachos em seu entorno devido ao escoamento superficial e ao lançamento de esgotos não tratados pela falta de acesso a serviços de esgotamento sanitário de grande parte da população. A ausência de tratamento terciário na ETE leva à poluição do riacho após o lançamento de seu efluente. Sudeste Brasil. Brasil . Brasil) SapucaíGuaçú Sapucaí Guaçú Prata São Paulo formas P Pontos 1 3 , 3) 5, 5 5) (ETE Ponto 7. 7 ANOVA. ANOVA (ANOVA) PCA. PCA (PCA) respectivamente (5 mostrouse mostrou autodepuração níveis população efluente (ANOVA (PCA (

Abstract Aim Our aim was to analyze the limnological characteristics of streams located in a luxury tourism municipality in the Serra da Mantiqueira (Southeast Brazil). Methods We analyzed water physical and chemical variables of six sampling sites located in three streams of the Sapucaí-Guaçú River Basin along the urban area of the municipality of Campos do Jordão and one sampling site in the Rio da Prata stream, as a reference location not impacted by urban pollution (São Paulo, Brazil). We measured some physical and chemical variables of the water and analyzed the concentration of nutrients (forms of N and P) in the streams close to the basin's sources (Sites 1, 2 and 3), within and downstream of the urban area (sites 4 and 5), downstream of the municipality's Wastewater Treatment Plant (WWTP) (Site 6) and the reference location (Site 7). To find out whether there were differences in limnological variables among the sampling sites we used the Analysis of Variance (ANOVA). To order the sampling sites according to the variation in their limnological characteristics we applied a Principal Component Analysis (PCA). Results Our results showed that sites 1, 2 and 3, although close to the sources, presented limnological changes in relation to the reference location (Site 7) due to urban occupations in their surroundings. The sampling sites 4 and 6 are the most polluted due to urbanization and the discharge of effluents from the WWTP, respectively. The stretch between these two locations (Site 5) proved to be less polluted due to the autodepuration process. Conclusions We concluded that the streams in the Sapucaí-Guaçú River Basin are polluted, although at different levels. The urban area of Campos do Jordão causes pollution of the streams in its surroundings due to surface runoff and the discharge of untreated sewage due to the lack of access to sewage services for a large part of the population. The absence of tertiary treatment at the WWTP leads to pollution of the stream after the release of its effluent. Southeast Brazil. Brazil . Brazil) SapucaíGuaçú Sapucaí Guaçú São Paulo forms P basins basin s Sites 1 3 , 3) 5, 5 municipalitys (WWTP Site 7. 7 ANOVA. ANOVA (ANOVA) PCA. PCA (PCA) respectively process levels population effluent (ANOVA (PCA

ABSTRACT Congenital heart disease (CHD) affects eight to ten out of every 1,000 births, resulting in approximately 23,057 new cases in Brazil in 2022. About one in four children with CHD requires surgery or other procedures in the first year of life, and it is expected that approximately 81% of these children with CHD will survive until at least 35 years of age. Professionals choosing to specialize in CHD surgery face numerous challenges, not only related to mastering surgical techniques and the complexity of the diseases but also to the lack of recognition by medical societies as a separate subspecialty. Furthermore, families face difficulties when access to services capable of providing treatment for these children. To address these challenges, it is essential to have specialized hospitals, qualified professionals, updated technologies, sustainable industry, appropriate financing, quality assessment systems, and knowledge generation. The path to excellence involves specialization across all involved parties. As we reflect on the importance of Pediatric Cardiovascular Surgery and Congenital Heart Diseases establishing themselves as a subspecialty of Cardiovascular Surgery, it is essential to look beyond our borders to countries like the United States of America and United Kingdom, where this evolution is already a reality. This autonomy has led to significant advancements in research, education, and patient care outcomes, establishing a care model. By following this path in Brazil, we not only align our practice with the highest international standards but also demonstrate our maturity and the ability to meet the specific needs of patients with CHD and those with acquired childhood heart disease. (CHD 1000 1 000 1,00 births 23057 23 057 23,05 2022 life 81 3 age challenges Furthermore hospitals professionals technologies industry financing systems generation parties Kingdom reality research education outcomes model 100 00 1,0 2305 2 05 23,0 202 8 10 0 1, 230 23, 20

Resumo Objetivo i) existe diferença no grau de contaminação nas diferentes partes da bacia nos compartimentos água, sedimento e macrófitas aquáticas? e ii) os três compartimentos respondem de forma semelhante à contaminação por metais? Metódos Amostras de água, sedimento e macrófitas aquáticas (Salvinia auriculata Aubl., Pistia stratiotes L., Ludwigia helminthorrhiza (Mart.) H. Hara e Eichhornia crassipes (Mart.) Solms) foram coletadas em 10 locais de amostragem em diferentes trechos de uma bacia hidrográfica tropical. Foram determinadas as concentrações de Fe, Pb, Ni, Zn, Mn, Cr, Cu e Cd e aos resultados nós aplicamos uma Análise de Componentes Principais (ACP), separadamente para cada compartimento, para ordenar os locais de coleta. Resultados Fe e Mn mostraram maiores concentrações do que os outros metais nas plantas e no sedimento. Com exceção do Mn, a ordem dos metais foi similar na água e no sedimento. No entanto, a ACP ordenou os locais de coleta de forma diferente. Nossos resultados demonstraram que a ordenação dos locais de amostragem por concentração de metais difere entre água, sedimento e macrófitas. Conclusão Nós concluímos que avaliar a contaminação de ambientes aquáticos por metais e os efeitos da contaminação na cadeia alimentar, não basta avalia-los apenas na água e sedimento, mas também em alguma comunidade aquática. i ii Salvinia Aubl Aubl. L L. Mart. Mart (Mart. H Solms 1 tropical Pb Ni Zn Cr ACP, , (ACP) compartimento entanto diferente alimentar avalialos avalia los aquática (Mart (ACP

Abstract Aim i) is there a difference in the level of contamination in the different parts of the basin in the water, sediment and aquatic macrophytes compartments? and ii) do the three compartments respond similarly to metal contamination? Methods Samples of water, sediment and aquatic macrophytes (Salvinia auriculata Aubl., Pistia stratiotes L., Ludwigia helminthorrhiza (Mart.) H. Hara and Eichhornia crassipes (Mart.) Solms) were collected at 10 sampling sites in different stretches of a tropical hydrographic basin. We determined the metal concentrations of Fe, Pb, Ni, Zn, Mn, Cr, Cu and Cd, and to the results we applied Principal Component Analysis (PCA), separately for each compartment, to order the sampling sites. Results Fe and Mn had higher concentrations than other metals in plants and sediment. With the exception of Mn, the order of metals was similar between water and sediment. However, the PCAs ordered the sampling sites differently. Our results demonstrated that the ordering of sampling sites by metal concentrations differs among water, sediment and macrophytes. Conclusions We conclude that to evaluate the contamination of aquatic environments by metals and the effects of contamination on the food chain, it is not enough to evaluate them only in water or sediment, but also in an aquatic community. i ii Salvinia Aubl Aubl. L L. Mart. Mart (Mart. H Solms 1 Pb Ni Zn Cr Cd PCA, PCA , (PCA) compartment However differently chain community (Mart (PCA

Resumo Objetivo: Estudar o efeito da administração antenatal de corticosteroides na hemodinâmica fetal mediante análise longitudinal do Doppler na artéria umbilical (AU) e artéria cerebral média (ACM). Materiais e Métodos: Este foi um estudo retrospectivo que incluiu 30 fetos com risco de nascimento pré-termo. Vinte e oito gestantes foram tratadas com betametasona para maturação pulmonar fetal. Os exames de Doppler da AU e da ACM foram realizados uma vez antes e depois da administração de corticosteroides, num total de três ou oito observações. Utilizamos o modelo linear hierárquico com abordagem Bayesiana. Foram construídos os intervalos de referência e testadas associações entre variáveis (idade gestacional e pré-eclâmpsia). Resultados: A média ± desvio-padrão da idade materna, idade gestacional na administração de betametasona e idade gestacional no parto foram 32,6 ± 5,89 anos, 30,2 ± 2,59 semanas e 32,9 ± 3,42 semanas, respectivamente. No Doppler da AU, verificou-se diminuição significativa do índice de pulsatilidade (IP) com a terapêutica com corticosteroides (média: 0,1147 [0,03687-0,191]; em três observações) (mediana: 0,1437 [0,02509-0,2627]; em oito observações). No entanto, não foi observada alteração significativa no IP do Doppler da ACM, independentemente da idade gestacional e do diagnóstico de pré-eclâmpsia. Conclusão: Os corticosteroides pré-natais induziram diminuição significativa no IP do Doppler da AU, mas não houve alteração na vasculatura cerebral. Objetivo (AU ACM. . (ACM) Métodos 3 prétermo. prétermo pré termo. termo pré-termo observações Bayesiana préeclâmpsia. préeclâmpsia eclâmpsia pré-eclâmpsia) Resultados desviopadrão desvio padrão materna 326 32 6 32, 589 5 89 5,8 anos 302 2 30, 259 59 2,5 329 9 342 42 3,4 respectivamente verificouse verificou se (IP (média 01147 0 1147 0,114 0,036870,191 0036870191 0,03687 0,191 03687 191 [0,03687-0,191] mediana (mediana 01437 1437 0,143 0,025090,2627 00250902627 0,02509 0,2627 02509 2627 [0,02509-0,2627] entanto eclâmpsia. pré-eclâmpsia Conclusão prénatais natais (ACM 58 8 5, 25 2, 34 4 3, 0114 114 0,11 036870 0,036870,19 003687019 003687 0,0368 0191 0,19 0368 19 [0,03687-0,191 0143 143 0,14 025090 0,025090,262 0025090262 002509 0,0250 02627 0,262 0250 262 [0,02509-0,2627 011 11 0,1 0,036870,1 00368701 00368 0,036 019 036 1 [0,03687-0,19 014 14 0,025090,26 002509026 00250 0,025 0262 0,26 025 26 [0,02509-0,262 01 0, 0,036870, 0036870 0036 0,03 03 [0,03687-0,1 0,025090,2 00250902 0025 0,02 026 0,2 02 [0,02509-0,26 0,036870 003 0,0 [0,03687-0, 0,025090, 0025090 002 [0,02509-0,2 00 [0,03687-0 0,025090 [0,02509-0, [0,03687- [0,02509-0 [0,03687 [0,02509- [0,0368 [0,02509 [0,036 [0,0250 [0,03 [0,025 [0,0 [0,02 [0, [0 [

Abstract Objective: To study the effect of antenatal corticosteroid administration on fetal hemodynamics using longitudinal analysis of Doppler waveforms in the umbilical artery (UA) and middle cerebral artery (MCA). Materials and Methods: This was a retrospective study that included 30 fetuses at risk for preterm birth. Twenty-eight pregnant women were treated with betamethasone for fetal lung maturation. Doppler examinations of the UA and MCA were performed once before and three or eight times after corticosteroid administration. We used a Bayesian hierarchical linear model. Reference ranges were constructed, and associations between variables (gestational age and pre-eclampsia) were tested. Results: The mean maternal age, gestational age at betamethasone administration, and gestational age at delivery were 32.6 ± 5.89 years, 30.2 ± 2.59 weeks, and 32.9 ± 3.42 weeks, respectively. On UA Doppler, there was a significant decrease in the pulsatility index (PI) after corticosteroid administration, with a mean of 0.1147 (credibility interval: 0.03687-0.191) in three observations and a median of 0.1437 (credibility interval: 0.02509-0.2627) in eight observations. However, there was no significant change in the Doppler MCA PI, regardless of gestational age and the presence or absence of pre-eclampsia. Conclusion: Although antenatal corticosteroid administration induced a significant decrease in the Doppler UA PI, we observed no change in the cerebral vasculature. Objective (UA MCA. . (MCA) Methods 3 birth Twentyeight Twenty maturation model constructed preeclampsia pre eclampsia pre-eclampsia tested Results 326 32 6 32. 589 5 89 5.8 years 302 2 30. 259 59 2.5 weeks 329 9 342 42 3.4 respectively PI (PI 01147 0 1147 0.114 credibility interval 0.036870.191 0036870191 0.03687 0.191 03687 191 0.03687-0.191 01437 1437 0.143 0.025090.2627 00250902627 0.02509 0.2627 02509 2627 0.02509-0.2627 However preeclampsia. eclampsia. Conclusion vasculature (MCA 58 8 5. 25 2. 34 4 3. 0114 114 0.11 036870 0.036870.19 003687019 003687 0.0368 0191 0.19 0368 19 0.03687-0.19 0143 143 0.14 025090 0.025090.262 0025090262 002509 0.0250 02627 0.262 0250 262 0.02509-0.262 011 11 0.1 0.036870.1 00368701 00368 0.036 019 036 1 0.03687-0.1 014 14 0.025090.26 002509026 00250 0.025 0262 0.26 025 26 0.02509-0.26 01 0. 0.036870. 0036870 0036 0.03 03 0.03687-0. 0.025090.2 00250902 0025 0.02 026 0.2 02 0.02509-0.2 0.036870 003 0.0 0.03687-0 0.025090. 0025090 002 0.02509-0. 00 0.03687- 0.025090 0.02509-0 0.02509-

ABSTRACT Introduction: Heart transplantation is the gold standard for advanced heart failure treatment. This study examines the survival rates and risk factors for early mortality in adult heart transplant recipients at a Brazilian center. Methods: This retrospective cohort study involved 255 adult heart transplant patients from a single center in Brazil. Data were collected from medical records and databases including three defined periods (2012-2015, 2016-2019, and 2020-2022). Statistical analysis employed Kaplan-Meier survival curves, Cox proportional hazards analysis for 30-day mortality risk factors, and Log-rank tests. Results: The recipients were mostly male (74.9%), and the mean age was 46.6 years. Main causes of heart failure were idiopathic dilated cardiomyopathy (33.9%), Chagas cardiomyopathy (18%), and ischemic cardiomyopathy (14.3%). The study revealed an overall survival of 68.1% at one year, 58% at five years, and 40.8% at 10 years after heart transplantation. Survivalimproved significantly over time, combining the most recent periods (2016 to 2022) it was 73.2% in the first year and 63% in five years. The main risk factors for 30-day mortality were longer time on cardiopulmonary bypass, the initial period of transplants (2012 to 2015), older age of the donor, and nutritional status of the donor (overweight or obese). The main causes of death within 30 days post-transplant were infection and primary graft dysfunction. Conclusion: The survival analysis by period demonstrated that the increased surgical volume, coupled with the team’s experience and modifications to the immunosuppression protocol, contributed to the improved early and mid-term outcomes. Introduction treatment Methods 25 Brazil 20122015, 20122015 2012 2015, 2015 (2012-2015 20162019, 20162019 2016 2019, 2019 2016-2019 20202022. 20202022 2020 2022 . 2020-2022) KaplanMeier Kaplan Meier curves 30day day Logrank Log rank tests Results 74.9%, 749 74.9% , 74 9 (74.9%) 466 46 6 46. 33.9%, 339 33.9% 33 (33.9%) 18%, 18 18% (18%) 14.3%. 143 14.3% 14 3 (14.3%) 681 68 1 68.1 58 408 40 8 40.8 (201 732 73 2 73.2 63 bypass 2015) overweight obese. obese obese) posttransplant post dysfunction Conclusion volume teams team s protocol midterm mid term outcomes 2012201 201 (2012-201 2016201 2016-201 2020202 202 2020-2022 74.9 7 (74.9% 4 33.9 (33.9% (18% 14.3 (14.3% 68. 5 40. (20 73. 201220 20 (2012-20 201620 2016-20 202020 2020-202 74. (74.9 33. (33.9 (18 14. (14.3 (2 20122 (2012-2 20162 2016-2 20202 2020-20 (74. (33. (1 (14. ( (2012- 2016- 2020-2 (74 (33 (14 2020- (7 (3

BACKGROUND In response to the coronavirus disease 2019 (Covid-19) pandemic, Brazil authorised the Astra Zeneca/Fiocruz vaccine in January 2021. As the Delta variant emerged in May 2021, interval between vaccine doses was adjusted. By September 2021, the Brazilian National Immunisation Program recommended a booster dose for individuals over 70, and later expanded the recommendation to all adults. OBJECTIVES Assess the equivalence of IgG antibody response against the Covid-19 S protein before and approximately 28 days after the third dose of a Covid-19 recombinant vaccine. Two groups received initial two doses with intervals of eight and 12 weeks. METHODS This is a phase IV clinical study, uncontrolled, non-randomised. The study proposes calculating the ratio of geometric means titres (GMT) 28 days after the third dose, with a target ratio of confidence interval (CI) between 0.77 and 1.3. FINDINGS In the primary endpoint, there was no equivalence between the eight- and 12-week intervals with a slight variation favouring the eight-week group. Post-third dose, both groups showed increases titres at 28 days, three months, six months and 12 months. Both groups responded similarly to Delta and Omicron BA.1, with a more significant increase for Delta. MAIN CONCLUSIONS The study showed strong and consistent immune response in all age groups receiving the Covid-19 recombinant vaccine. Third dose elicited an increase in GMT by at least three times aligned with Ministry of Health strategies emphasising Bio-Manguinhos crucial role in pandemic control in the country. 201 Covid19 Covid 19 (Covid-19 ZenecaFiocruz Zeneca Fiocruz 2021 adjusted 70 adults Covid-1 2 1 weeks uncontrolled nonrandomised. nonrandomised non randomised. randomised non-randomised (GMT CI (CI 077 0 77 0.7 13 3 1.3 endpoint 12week week eightweek group Postthird Post BA1 BA BA.1 BioManguinhos Bio Manguinhos country 20 Covid1 (Covid-1 202 7 Covid- 07 0. 1. BA. (Covid- (Covid

RESUMO: Objetivo: Identificar características e associar as complicações de pacientes oncológicos operados pelo Grupo de Coluna no Instituto do Câncer do Estado de São Paulo (ICESP) no período de janeiro de 2020 a dezembro de 2020. Métodos: Análise retrospectiva de prontuários de pacientes operados pelo grupo de coluna. Resultados: Do total de 62 casos, a maioria, 69,4%, residentes do estado de São Paulo. Havia 24,2% de tabagistas, destes 93,3% foram a óbito. Identificamos que 48,4% não tinham histórico familiar de CA. Foi identificado que 62,9% receberam radioterapia e 75,8% estavam sob tratamento sistêmico. Foram levantadas 3 transfusões pré-operatórias, 16 transfusões intra-operatórias e 5 transfusões pós-operatórias. Encontramos associação nos casos que necessitaram de transfusão pós-operatória com os casos de infecção, p=0,019. O total de casos de infecção pós-operatória foi de 9 casos (14,5%). Conclusões: Infecções pós-operatórias são eventos indesejáveis e estão presentes no período pós-operatório no contexto oncológico e podem estar associadas às condições clínicas do paciente. Nível de Evidencia III; Estudo retrospectivo. RESUMO Objetivo ICESP (ICESP 202 Métodos coluna Resultados 6 maioria 694 69 4 69,4% 242 24 2 24,2 tabagistas 933 93 93,3 óbito 484 48 48,4 CA 629 62,9 758 75 8 75,8 sistêmico préoperatórias, préoperatórias pré operatórias, operatórias pré-operatórias 1 intraoperatórias intra pósoperatórias. pósoperatórias pós operatórias. pósoperatória operatória p0019 p 0 019 p=0,019 14,5%. 145 14,5% . 14 (14,5%) Conclusões pósoperatório operatório paciente III retrospectivo 20 69,4 24, 93, 48, 62, 7 75, p001 01 p=0,01 14,5 (14,5% 69, p00 p=0,0 14, (14,5 p0 p=0, (14, p=0 (14 p= (1 (

ABSTRACT Objective: To identify characteristics and associate the complications in cancer patients operated on by the Spine Group at the Cancer Institute of the State of São Paulo (ICESP) from January 2020 to December 2020. Methods: Retrospective analysis of medical records of patients operated on by the spine group. Results: Of the total of 62 cases, the majority, 69.4%, were residents of the state of São Paulo. There were 24.2% of smokers, of which 93.3% died. We identified that 48.4% had no family history of CA. It was identified that 62.9% received radiotherapy, and 75.8% were undergoing systemic treatment. There were three preoperative transfusions, 16 intraoperative transfusions, and five postoperative transfusions. We found an association between cases that required postoperative transfusion and cases of infection, p=0.019. The total number of postoperative infections was 9 cases (14.5%). Conclusions: Postoperative infections are undesirable events in the oncological context in the postoperative period and may be associated with the patient’s clinical conditions. Level of Evidence III; Retrospective Study. Objective ICESP (ICESP 202 Methods group Results 6 majority 694 69 4 69.4% 242 24 2 24.2 smokers 933 93 3 93.3 died 484 48 48.4 CA 629 62.9 radiotherapy 758 75 8 75.8 treatment transfusions 1 infection p0019 p 0 019 p=0.019 14.5%. 145 14.5% . 14 5 (14.5%) Conclusions patient s conditions III Study 20 69.4 24. 93. 48. 62. 7 75. p001 01 p=0.01 14.5 (14.5% 69. p00 p=0.0 14. (14.5 p0 p=0. (14. p=0 (14 p= (1 (

RESUMEN: Objetivo: Identificar características y complicaciones asociadas en pacientes con cáncer operados por el Grupo de Columna del Instituto del Cáncer del Estado de São Paulo (ICESP) de enero de 2020 a diciembre de 2020. Métodos: Análisis retrospectivo de historias clínicas de pacientes operados del grupo de columna. Resultados: Del total de 62 casos, la mayoría, 69,4%, eran residentes del estado de São Paulo. Hubo un 24,2% de fumadores, de los cuales el 93,3% falleció. Identificamos que el 48,4% no tenía antecedentes familiares de AC. Se identificó que el 62,9% recibía radioterapia y el 75,8% estaba en tratamiento sistémico. Hubo 3 transfusiones preoperatorias, 16 transfusiones intraoperatorias y 5 transfusiones posoperatorias. Se encontró asociación entre los casos que requirieron transfusión postoperatoria y los casos de infección, p=0,019. El número total de casos de infección postoperatoria fue de 9 casos (14,5%). Conclusiones: Las infecciones postoperatorias son eventos indeseables y están presentes en el postoperatorio en el contexto oncológico y pueden estar asociadas a las condiciones clínicas del paciente. Nivel de Evidencia III; Estudio retrospectivo. RESUMEN Objetivo ICESP (ICESP 202 Métodos columna Resultados 6 mayoría 694 69 4 69,4% 242 24 2 24,2 fumadores 933 93 93,3 falleció 484 48 48,4 AC 629 62,9 758 75 8 75,8 sistémico preoperatorias 1 posoperatorias p0019 p 0 019 p=0,019 14,5%. 145 14,5% . 14 (14,5%) Conclusiones paciente III 20 69,4 24, 93, 48, 62, 7 75, p001 01 p=0,01 14,5 (14,5% 69, p00 p=0,0 14, (14,5 p0 p=0, (14, p=0 (14 p= (1 (

Abstract Background In general, patients are referred for rheumatological evaluation due to isolated laboratory abnormalities, especially antinuclear antibody (ANA) positivity, with the risk of more severe patients remaining on the waiting list for longer than desired. The aim of this study was to analyze the demographic, clinical, and laboratory information of patients referred to a specialized rheumatological care unit because of positive antinuclear antibody. Methods This is a retrospective study of 99 out of 1670 patients seen by the same rheumatologist between 01/01/2011 and 01/01/2019. Patients whose referrals were exclusively due to the ANA test result and the specialist’s final diagnosis being “abnormal finding of serum immunological test” (ICD-10 R769) were included. Sociodemographic, clinical, and laboratory information were extracted from the consulting rheumatologist’s chart. Descriptive statistics were used for data analysis. Results A total of 99 patients were included, most of whom were female (84.8%) with a median age of 49 years. At the moment of specialist’s appointment, 97 patients (97.9%) repeated the ANA test, and 77 patients remained positive. Of these, only 35 (35.35%) were in a high titer range (greater than or equal to 1:320). Complete blood count for cytopenia’s investigation was not performed in a high percentage of patients (22.2%), as well as urinalysis (31.3%). In addition, more than 70% of patients score 0 to 1 classification criteria for Systemic Lupus Erythematosus, according to SLE - ACR 1987 (American College of Rheumatology) and SLICC 2012 (Systemic Lupus International Collaborating Clinics). Conclusions Most patients are still referred for specialized evaluation due to the misinterpretation of laboratory tests that were inappropriately requested in patients without clinical evidence of autoimmune rheumatic disease. general abnormalities (ANA positivity desired demographic 9 167 01012011 01 2011 01/01/201 01012019 2019 01/01/2019 specialists specialist s abnormal ICD10 ICD 10 (ICD-1 R769 R included Sociodemographic rheumatologists chart analysis 84.8% 848 84 8 (84.8% 4 years appointment 97.9% 979 (97.9% 7 these 3 35.35% 3535 (35.35% greater 1320. 1320 320 . 1:320) cytopenias cytopenia 22.2%, 222 22.2% , 22 2 (22.2%) 31.3%. 313 31.3% 31 (31.3%) addition 70 Erythematosus 198 American Rheumatology 201 Clinics. Clinics Clinics) disease 16 0101201 01/01/20 ICD1 (ICD- R76 84.8 (84.8 97.9 (97.9 35.35 353 (35.35 132 32 1:320 22.2 (22.2% 31.3 (31.3% 19 20 010120 01/01/2 (ICD R7 84. (84. 97. (97. 35.3 (35.3 13 1:32 22. (22.2 31. (31.3 01012 01/01/ (84 (97 35. (35. 1:3 (22. (31. 0101 01/01 (8 (9 (35 1: (22 (31 010 01/0 ( (3 (2 01/

Resumo O artigo tem como objetivo consolidar dados referentes à formação em Educação Física (EF) no Brasil no período de 1995 a 2020. Para essa análise, foram utilizadas as principais fontes disponíveis sobre esses dados, tanto na literatura científica sobre Educação Física, quanto nas Sinopses Estatísticas da Educação Superior fornecidas pelo Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP). Os resultados, indicam discrepância significativa entre os dados das Sinopses Estatísticas com os dados encontrados na literatura disponível, evidenciando problemas metodológicos, em uma parcela considerável dos artigos que tratam dos cursos de EF. Estes artigos omitem fontes, procedimentos e não utilizam filtros adequados na obtenção de dados. Durante o período analisado, houve expansão da formação em Educação Física, especialmente no ano de 2020, quando o número de matrículas em cursos à distância se sobressaiu e a predominância dos cursos de bacharelado, que se tornou maioria a partir de 2019. A criação dos cursos à distância, demanda revisão dos indicadores de crescimento da formação em EF, os quais devem considerar o número de cursos, a modalidade, as matrículas e os concluintes. Apesar do crescimento constante nos indicadores desde o início da elaboração da Sinopse Estatística em 1995, houve uma diminuição no número de cursos e matrículas a partir de 2017, sugerindo um possível saturamento na procura por formação em Educação Física. EF (EF 199 2020 análise INEP. INEP . (INEP) resultados disponível metodológicos analisado bacharelado 2019 modalidade concluintes 2017 19 202 (INEP 201 1 20 2

Abstract The article aims to consolidate data on physical education (PE) training in Brazil from 1995 to 2020. It analyzed the main sources available on these data as well as those used by the scientific literature in the field of PE and built indicators for data extraction establishing as a database the Statistical Synopses of Higher Education, of the National Institute of Educational Studies and Research Anísio Teixeira. The results indicate a significant discrepancy between the data from the Statistical Synopses and those from the literature, since a significant portion of the articles that present data on PE courses contain methodological problems, by not indicating the sources, procedures and not using adequate filters to determine the data found. There was an expansion of training in PE in the period, which in 2020 had a higher number of enrollments in distance learning (DL) courses and bachelor's degree programs courses become the majority from 2019. With the creation of distance courses, only the indicator of the number of courses is not the most appropriate to analyze the growth of training, which should be combined with others such as modality, enrollment, and graduation. Since the beginning of the elaboration of the Statistical Synopsis, in 1995, the number of courses and their indicators were increasing, but in 2017 the number of courses and enrollments began to decrease, which may indicate a saturation in the demand for training in PE. (PE 199 Education Teixeira problems found period 202 DL (DL bachelors bachelor s 2019 modality enrollment graduation Synopsis increasing 201 decrease 19 20 1 2

Resumen Tiene como objetivo consolidar los datos sobre el entrenamiento en educación física en Brasil, en el intervalo de tiempo entre 1995 y 2020. Se analizaron las principales fuentes disponibles sobre estos datos, así como las utilizadas por la literatura científica en el campo de la Educación Física, y se construyeron indicadores para la extracción de datos estableciendo como base de datos las Sinopsis Estadísticas de la Educación Superior, del Instituto Nacional de Estudios e Investigaciones Educativas Anísio Teixeira. Los resultados indican discrepancia significativa entre los datos de las Sinopsis Estadísticas y los de la literatura, ya que una parte significativa de los artículos que presentan datos sobre los cursos contienen problemas metodológicos, al no indicar las fuentes, procedimientos y no utilizar filtros adecuados para determinar los datos encontrados. Hubo una expansión de la formación en Educación Física en el período, que en 2020 tuvo un mayor número de matrículas en cursos de educación a distancia y los cursos de licenciatura se convirtieron en la mayoría a partir de 2019. Con la creación de cursos a distancia, solo el indicador del número de cursos no es el más adecuado para analizar el crecimiento de la formación, que debe combinarse con otros como modalidad, matrícula y graduación. Desde el inicio de la elaboración de la Sinopsis Estadística, el número de cursos y sus indicadores fueron aumentando, pero en 2017 el número de graduados e inscripciones comenzó a disminuir, lo que puede indicar una saturación en la demanda de formación en Educación Física. Brasil 199 Superior Teixeira metodológicos encontrados período 202 2019 modalidad graduación Estadística aumentando 201 disminuir 19 20 1 2

Resumo O objetivo deste trabalho foi determinar os níveis de acidez para obter os atributos químicos do solo adequados à máxima produção de frutos de amoreiras-pretas cultivadas em solos ácidos submetidos a doses crescentes de calcário. Foram avaliadas as cultivares de amoreira-preta BRS Tupy, Brazos, Guarani e BRS Xavante nos solos Latossolo Vermelho Distroférico (LVdf) e Latossolo Vermelho distrófico (LVd), aos quais foram aplicadas quatro doses de calcário dolomítico (0, 1,5, 3,0 e 6,0 Mg ha-1). Foram avaliados o efeito da calagem sobre os atributos químicos do solo, em arranjo fatorial 2×4 (solos e doses de calcário), bem como o teor de nutrientes foliares e a produção de frutos, em arranjo fatorial 2×4×4 (solos, doses de calcário e cultivares). A produção máxima de frutos foi obtida com 3,3 Mg ha-1 de calcário dolomítico. As cultivares de amoreira-preta apresentaram alta demanda por Ca, Mg e saturação por bases e baixa tolerância ao alumínio nos solos. A partir de 3,3 Mg ha-1 de calcário dolomítico, a produção máxima de frutos de amoras-pretas cultivadas em solos ácidos é obtida com pH 5,6, saturação máxima tolerada de alumínio de 6%, concentração de Ca e Mg de 45,3 mmolc kg-1 e saturação por bases de 48,3%. amoreiraspretas amoreiras pretas amoreirapreta amoreira preta Tupy Brazos LVdf (LVdf LVd, LVd , (LVd) 0, 0 (0 15 1 5 1,5 30 3 3, 60 6 6, ha1. ha1 ha . ha-1) 24 2 4 2× calcário, calcário) 244 2×4× solos, cultivares. cultivares) 33 ha- amoraspretas amoras 56 5,6 6% 453 45 45, kg1 kg kg- 483 48 48,3% (LVd ( 1, 5, 48,3 48,

Abstract The objective of this work was to determine the acidity levels to obtain adequate soil chemical attributes for the maximum fruit yield of blackberry trees grown in acidic soils subjected to increasing limestone rates. The BRS Tupy, Brazos, Guarani, and BRS Xavante blackberry cultivars were evaluated on the Typic Hapludox (LVdf) and Rhodic Hapludox (LVd) soils, to which four rates of dolomitic limestone were applied (0, 1.5, 3.0, and 6.0 Mg ha-1). The effect of liming on soil chemical attributes, in a 2×4 factorial arrangement (soils and limestone rates), as well as leaf nutrient content and fruit yield, in a 2×4×4 factorial arrangement (soils, limestone rates, and cultivars), were evaluated. The maximum fruit yield was obtained with 3.3 Mg ha-1 dolomitic limestone. The blackberry cultivars showed a high demand for Ca, Mg, and base saturation and a low tolerance to aluminum in the soils. From 3.3 Mg ha-1 dolomitic limestone, the maximum fruit yield of blackberry trees grown in acidic soils is obtained with pH 5.6, maximum tolerated aluminum saturation of 6%, Ca and Mg concentration of 45.3 mmolc kg-1, and base saturation of 48.3%. Tupy Brazos Guarani LVdf (LVdf LVd (LVd 0, 0 (0 15 1 5 1.5 30 3 3.0 60 6 6. ha1. ha1 ha . ha-1) 24 2 4 2× , rates) 244 2×4× cultivars, cultivars) 33 3. ha- 56 5.6 6% 453 45 45. kg1, kg1 kg 1, kg-1 483 48 48.3% ( 1. 5. kg- 48.3 48.