Resumen La transformación de la atención de salud mental en Portugal en los últimos años ha sido fundamental para una mayor humanización, una mejor organización y proximidad. Con un enfoque predominantemente comunitario, las enfermeras de salud mental desempeñan un papel importante en su implementación debido a sus conocimientos y prácticas dentro de equipos interdisciplinarios. Contribuyen a través de intervenciones conjuntas y autónomas a lo largo del ciclo vital, promoviendo la salud mental, interpretando el sufrimiento mental y brindando apoyo en enfermedades mentales, tanto en entornos comunitarios como hospitalarios.

Abstract The transformation of mental healthcare in Portugal in recent years has been instrumental in promoting greater humanisation, improved organisation, and proximity to patients. With a predominantly community-focused approach, mental health nurses play a crucial role in its implementation through their knowledge and practice within interdisciplinary teams. They contribute through joint and autonomous interventions across the lifespan, promoting mental health, interpreting mental distress, and providing support for mental illness in community and hospital settings.

Resumo A transformação dos cuidados de saúde mental em Portugal, nos anos recentes tem sido determinante para uma maior humanização, melhor organização e proximidade. Com um foco predominantemente comunitário, os enfermeiros especialistas em Enfermagem de Saúde Mental e Psiquiátrica têm um importante papel na sua implementação, pelo seu conhecimento e prática, incluídos em equipas interdisciplinares, dando contributos através de intervenções conjuntas e autónomas, ao longo do ciclo vital, através da promoção da saúde mental, interpretação do sofrimento mental e acompanhamento na doença mental, em contextos comunitários e hospitalares.

Com o mote de identificar o tratamento dedicado à literatura na Base Nacional Comum Curricular - Ensino Médio, o presente estudo propõe um debate sobre o espaço minguado que o documento reserva à área. Para tanto, nos norteamos pelo conceito de “não-lugar” que, em Augé (2005), corresponde a um ambiente no qual imperam o utilitarismo e a transitoriedade, isto é, um espaço, ao mesmo tempo, lotado e vazio, que enquanto estrutura física existe de fato, mas sem construção identitária, nem valor relacional e histórico, por isso, banal. Circunscrevendo a literatura ao “não-lugar literário”, ao fazer recomendações vazias, antagônicas, inconsistentes e, às vezes, impraticáveis ​​ao campo artístico-literário, a BNCC opera tanto no sentido de esgotar o acesso à literatura em âmbito educacional – já que colabora para o apagamento dessa arte nesse espaço –, como também contribui para, disfarçadamente, direcionar-la ao caminho da utilidade mercadológica e de outros ideais neoliberais, cujo efeito principal é a anulação das potências dessa arte plural. Imbuída de perspectivas intrincadas e vazias de sentidos em um texto insignificante, na nova BNCC, a literatura não somente não logra o relevo de arte como também é (in)oportunamente enfraquecida, impulsionada ao esquecimento e/ou até mesmo a um propósito afastado dela.

Com o objetivo de identificar o tratamento dedicado à literatura na Base Nacional Comum Curricular (BNCC), este estudo propõe um debate sobre o espaço limitado que o documento reserva para a área. Para tanto, guiamo-nos pelo conceito de “não-lugar” que, em Augé (2005), corresponde a um ambiente em que prevalecem o utilitarismo e a transitoriedade, ou seja, um espaço, ao mesmo tempo, lotado e vazio, que como estrutura física realmente existe, mas sem construção identitária, nem valor relacional e histórico, portanto, banal. Circunscrevendo a literatura ao “não-lugar literário”, ao fazer recomendações vazias, antagônicas, inconsistentes e, por vezes, impraticáveis ​​ao campo artístico-literário, a BNCC atua tanto no sentido de esgotar o acesso à literatura no contexto educacional – já que colabora para o apagamento desta arte neste espaço –, mas também contribui para, veladamente, direcioná-la para o caminho da utilidade mercadológica e de outros ideais neoliberais, cujo principal efeito é a anulação dos poderes desta arte plural. Imbuída de perspectivas intrincadas e esvaziada de sentidos em um texto insignificante, na nova BNCC a literatura não apenas não consegue alcançar o status de arte, mas também é (in)oportunamente fragilizada, levada ao esquecimento e/ou mesmo a um propósito muito distante do isto.

Con el objetivo de identificar el tratamiento dedicado a la literatura en la Base Curricular Común Nacional (BNCC, en Portugués), este estudio propone un debate sobre el espacio limitado que el documento reserva para el área. Para ello nos guiamos por el concepto de “no lugar” que, en Augé (2005), corresponde a un entorno en el que prevalecen el utilitarismo y la fugacidad, es decir, un espacio, al mismo tiempo, poblado y vacío, que como estructura física existe realmente, pero sin construcción identitaria, ni valor relacional e histórico, por tanto, banal. Circunscribiendo la literatura al “no lugar literario”, haciendo recomendaciones vacías, antagónicas, inconsistentes y, a veces, poco prácticas al campo artístico-literario, el BNCC actúa tanto para agotar el acceso a la literatura en el contexto educativo – ya que colabora durante la borradura de este arte en este espacio–, pero también contribuye a, encubiertamente, encaminarlo hacia el camino del marketing utilitario y otros ideales neoliberales, cuyo principal efecto es la anulación de los poderes de este arte plural. Imbuida de perspectivas intrincadas y vaciada de significados en un texto insignificante, en el nuevo BNCC, la literatura no sólo no logra alcanzar el estatus de arte sino que también es (in)oportunamente debilitada, conducida al olvido y/o incluso a un propósito muy alejado del él.

Abstract Background: The European Society of Cardiology guidelines recommend an LDL-cholesterol (LDL-C) < 55 mg/dL for patients with established cardiovascular disease. While the Friedewald equation to estimate LDL-C is still widely used, the newer Martin-Hopkins equation has shown greater accuracy. Objectives: We aimed to assess: A) the proportion of patients reaching LDL-C goal and the therapies used in a tertiary center; B) the impact of using the Martin-Hopkins method instead of Friedewald’s on the proportion of controlled patients. Methods: A single-center cross-sectional study including consecutive post-myocardial infarction patients followed by 20 cardiologists in a tertiary hospital. Data was collected retrospectively from clinical appointments that took place after April 2022. For each patient, the LDL-C levels and attainment of goals were estimated from an ambulatory lipid profile using both Friedewald and Martin-Hopkins equations. A two-tailed p-value of < 0.05 was considered statistically significant for all tests. Results: Overall, 400 patients were included (aged 67 ± 13 years, 77% male). Using Friedewald’s equation, the median LDL-C under therapy was 64 (50-81) mg/dL, and 31% had LDL-C within goals. High-intensity statins were used in 64% of patients, 37% were on ezetimibe, and 0.5% were under PCSK9 inhibitors. Combination therapy of high-intensity statin + ezetimibe was used in 102 patients (26%). Applying the Martin-Hopkins method would reclassify a total of 31 patients (7.8%). Among those deemed controlled by Friedewald’s equation, 27 (21.6%) would have a Martin-Hopkins’ LDL-C above goals. Conclusions: Less than one-third of post-myocardial infarction patients had LDL-C within the goal. Applying the Martin-Hopkins equation would reclassify one-fifth of presumably controlled patients into the non-controlled group. Background LDLcholesterol LDL cholesterol LDLC C (LDL-C 5 mgdL mg dL disease MartinHopkins Martin Hopkins accuracy Objectives assess center B Friedewalds s Methods singlecenter single crosssectional cross sectional postmyocardial post myocardial 2 hospital 2022 patient equations twotailed two tailed pvalue p value 005 0 05 0.0 tests Results Overall 40 aged 6 1 years 77 male. male . male) 5081 50 81 (50-81 Highintensity High intensity 37 0.5 PCSK inhibitors highintensity high 10 26%. 26 26% (26%) 3 7.8%. 78 7.8% 7 8 (7.8%) 21.6% 216 21 (21.6% Conclusions onethird one third onefifth fifth noncontrolled non group 202 00 0. 4 508 (50-8 (26% 7.8 (7.8% 21.6 (21.6 (50- (26 7. (7.8 21. (21. (50 (2 (7. (21 (5 ( (7

Resumo Fundamento: As diretrizes da Sociedade Europeia de Cardiologia recomendam um nível de colesterol LDL (LDL-C) < 55 mg/dL para pacientes com doença cardiovascular estabelecida. Embora a fórmula de Friedewald ainda seja amplamente utilizada para estimar o LDL-C, a fórmula mais recente de Martin-Hopkins mostrou maior precisão. Objetivos: Nosso objetivo foi avaliar: A) a proporção de pacientes que atingiram a meta de LDL-C e as terapias utilizadas em um centro terciário; B) o impacto da utilização do método de Martin-Hopkins em vez do método de Friedewald na proporção de pacientes controlados. Métodos: Estudo transversal monocêntrico, incluindo pacientes consecutivos pós-infarto do miocárdio, acompanhados por 20 cardiologistas, em um hospital terciário. Os dados foram coletados retrospectivamente de consultas clínicas realizadas após abril de 2022. Para cada paciente, os níveis de LDL-C e o atingimento das metas foram estimados a partir de um perfil lipídico ambulatorial, utilizando as fórmulas de Friedewald e Martin-Hopkins. Um valor-p bicaudal < 0,05 foi considerado estatisticamente significativo para todos os testes. Resultados: Foram incluídos 400 pacientes (com 67 ± 13 anos, 77% do sexo masculino). Utilizando a fórmula de Friedewald, a mediana de LDL-C sob terapia foi de 64 (50-81) mg/dL, e 31% tinham LDL-C dentro da meta. Estatinas de alta intensidade foram usadas em 64% dos pacientes, 37% estavam em uso de ezetimiba e 0,5% estavam em uso de inibidores de PCSK9. A terapia combinada de estatina de alta intensidade + ezetimiba foi utilizada em 102 pacientes (26%). A aplicação do método de Martin-Hopkins reclassificaria um total de 31 pacientes (7,8%). Entre aqueles considerados controlados pela fórmula de Friedewald, 27 (21,6%) teriam LDL-C estimado por Martin-Hopkins acima da meta. Conclusões: Menos de um terço dos pacientes pós-infarto do miocárdio apresentaram LDL-C dentro da meta. A aplicação da fórmula de Martin-Hopkins reclassificaria um quinto dos pacientes presumivelmente controlados no grupo de pacientes não controlados. Fundamento LDLC C (LDL-C 5 mgdL mg dL estabelecida LDLC, C, MartinHopkins Martin Hopkins precisão Objetivos avaliar terciário B Métodos monocêntrico pósinfarto pós infarto 2 cardiologistas 2022 paciente ambulatorial MartinHopkins. Hopkins. valorp valor p 005 0 05 0,0 testes Resultados 40 6 1 anos 77 masculino. masculino . masculino) 5081 50 81 (50-81 37 0,5 PCSK9 PCSK 10 26%. 26 26% (26%) 3 7,8%. 78 7,8% 7 8 (7,8%) 21,6% 216 21 (21,6% Conclusões 202 00 0, 4 508 (50-8 (26% 7,8 (7,8% 21,6 (21,6 (50- (26 7, (7,8 21, (21, (50 (2 (7, (21 (5 ( (7

ABSTRACT BACKGROUND: Precisely determining the aspects related to an instrument's validity and reliability measures allows for greater assurance of the quality of the results. OBJECTIVES: To analyze the psychometric properties of The Providers Survey in the Brazilian context of mental health services. DESIGN AND SETTING: The instrument validation study was conducted in Montes Claros, Minas Gerais, Brazil. METHODS: The validation study was conducted using the Consensus-based Standards for the Selection of Health Measurement Instruments checklist to analyze its validity and reliability. RESULTS: A committee of expert judges performed content validation after which the Content Validity Index was calculated. Construct validation took place through Exploratory Factor Analysis using the Kaiser-Meyer-Olkin Test criterion and Bartlett's Sphericity Test. Reliability was verified using test-retest reliability. The significance level adopted for the statistical tests was 5% (P < 0.05). The final instrument comprised 54 questions. The Content Validity Index was 97%. Exploratory Factor Analysis identified a Kaiser-Meyer-Olkin index of 0.901 and Bartlett's Sphericity Test with P < 0.001. We obtained a Cronbach's alpha coefficient of 0.95 and an intraclass correlation coefficient of 0.849. CONCLUSIONS: The Providers Survey, translated and adapted into Portuguese, was named the Work Assessment Instrument for the Recovery of Mental Health. It presented adequate psychometric properties for evaluating work-related practices for the recovery of psychosocial care network users. BACKGROUND instruments s results OBJECTIVES services SETTING Claros Gerais Brazil METHODS Consensusbased Consensus based RESULTS calculated KaiserMeyerOlkin Kaiser Meyer Olkin Bartletts Bartlett testretest test retest 5 0.05. 005 0.05 . 0 05 0.05) questions 97 97% 0901 901 0.90 0001 001 0.001 Cronbachs Cronbach 095 95 0.9 0849 849 0.849 CONCLUSIONS Portuguese workrelated work users 00 0.0 9 090 90 000 0.00 09 0. 084 84 0.84 08 8 0.8

ABSTRACT: Cadmium (Cd) is a heavy metal that is extremely dangerous to human health and can be found naturally in soils, deposited through industrial waste or phosphate fertilization. In this study, we evaluated the morphological responses of in vitro grown plants of potato in the presence of Cd, and define a procedure for assessing Cd sensitivity of different clones. The potato clone SMIJ461-1 was cultured in the presence of Cd at concentrations of 0, 20, 40, 60, 80, 90, 110, 120, 140, and 160 µM. Survival, rooting, number and height of shoots, leaf and root counts were evaluated at 7, 14, 21, and 28 days of cultivation. Adverse effects of Cd on the growth of the potato plants, exerted in a concentration-dependent manner, were observed for shoot height, leaf and root counts. Results of this study indicated that Cd concentrations of 0, 45, 90, and 135 µM can be used for future in vitro evaluation of potato clone sensitivity to Cd exposure. ABSTRACT (Cd soils fertilization clones SMIJ4611 SMIJ SMIJ461 1 SMIJ461- 0 20 40 60 80 90 110 120 140 16 Survival rooting shoots 7 14 21 2 cultivation concentrationdependent concentration dependent manner 45 13 exposure SMIJ46 4 6 8 9 11 12 SMIJ4

RESUMO: O cádmio (Cd) é um metal pesado extremamente perigoso à saúde humana, podendo ser encontrado naturalmente nos solos, depositado através de resíduos industriais ou da adubação fosfatada. Este trabalho teve por objetivo avaliar as respostas morfológicas de plantas de batata cultivadas in vitro na presença de Cd e definir uma metodologia para inferir sobre a sensibilidade de diferentes clones. Foi estudado o clone SMIJ461-1 de batata, nas concentrações de 0, 20, 40, 60, 80, 90, 110, 120, 140, 160 µM de Cd adicionadas ao meio de cultura. A sobrevivência, o enraizamento, o número de brotações, a altura da parte aérea e o número de folhas e raízes foram avaliados aos 7, 14, 21 e 28 dias de cultivo. Foram observados efeitos adversos de concentrações de Cd sobre o crescimento in vitro das plantas de batata do clone SMIJ461-1 para a altura da parte aérea e o número de folhas e raízes, sendo estes efeitos dependentes das concentrações de Cd adicionadas ao meio de cultura. Os resultados deste estudo indicam que as concentrações de 0, 45, 90 e 135 µM de Cd podem ser utilizadas para a avaliação in vitro da sensibilidade de clones de batata a presença de Cd. RESUMO (Cd humana solos fosfatada SMIJ4611 SMIJ SMIJ461 1 SMIJ461- 0 20 40 60 80 110 120 140 16 cultura sobrevivência enraizamento brotações 7 14 2 cultivo 45 9 13 SMIJ46 4 6 8 11 12 SMIJ4

ABSTRACT: The resistance of Echinochloa crus-galli (barnyardgrass) to cyhalofop-p-butyl has already been confirmed in rice fields in Santa Catarina, Brazil. However, it is not known if this resistance affects other ACCase inhibitors. This study evaluated the occurrence of cross-resistance in Echinochloa crus-galli biotypes from the main rice-growing regions of Santa Catarina to ACCase inhibitors. The research was conducted in a greenhouse, using a completely randomized design with a factorial scheme that included three ACCase-inhibiting herbicides (cyhalofop-p-butyl, quizalofop-p-ethyl, and profoxydim) belonging to two chemical groups (aryl-oxifenoxi-propionates and cyclohexanediones), eight herbicide doses, and four biotypes evaluated in the F1 generation and two biotypes evaluated in the F2 generation. These biotypes were selected based on the results of a preliminary trial with 21 populations. The herbicides were applied when the plants presented two true leaves. After control evaluations, the lethal dose required to control 50% and 80% of the population (LD50 and LD80) and the resistance factor (RF) were determined by nonlinear regression. The results showed that only one biotype from Tubarão, Santa Catarina met all statistical and agronomic criteria and had cross-resistance to ACCase inhibitors confirmed. In both generations, the RF was greater than 1.0, and the dose required to achieve 80% control exceeded the maximum recommended dose on the label. Resistance levels were higher for herbicides belonging to the aryl-oxifenoxi-propionate chemical group, with RF greater than 7.0. For the cyclohexanedione chemical group, the RF was less than 5.0. ABSTRACT crusgalli crus galli barnyardgrass (barnyardgrass cyhalofoppbutyl cyhalofop p butyl Brazil However crossresistance cross ricegrowing growing greenhouse ACCaseinhibiting inhibiting cyhalofoppbutyl, butyl, (cyhalofop-p-butyl quizalofoppethyl, quizalofoppethyl quizalofop ethyl, ethyl quizalofop-p-ethyl profoxydim aryloxifenoxipropionates aryl oxifenoxi propionates cyclohexanediones, cyclohexanediones , cyclohexanediones) doses F 2 populations leaves evaluations 50 80 LD50 LD (LD5 LD80 (RF regression Tubarão generations 10 1 0 1.0 label aryloxifenoxipropionate propionate group 70 7 7.0 5 5.0 8 LD5 (LD LD8 1. 7. 5.

RESUMO: A resistência de capim-arroz (Echinochloa crus-galli) ao cyhalofop-p-butyl já foi confirmada em áreas de produção de arroz de Santa Catarina, entretanto não se sabe se essa resistência compromete outros inibidores da ACCase. O objetivo desse trabalho foi avaliar a ocorrência de resistência cruzada em biótipos de capim-arroz das principais regiões orizícolas do Estado de Santa Catarina a inibidores de ACCase. A pesquisa foi desenvolvida em casa de vegetação, em delineamento inteiramente casualizado com esquema fatorial, sendo: três herbicidas inibidores de ACCase (cyhalofop-p-butyl; quizalofop-p-ethyl e profoxydim) pertencentes a dois grupos químicos (ariloxifenoxipropionatos e ciclohexanodionas); oito doses dos herbicidas e quatro biótipos foram avaliados na geração F1 e dois biótipos na geração F2. Estes biótipos foram selecionados a partir dos resultados de um ensaio preliminar com 21 populações. A aplicação foi realizada quando as plantas apresentaram duas folhas verdadeiras. Após as avaliações de controle determinou-se, por regressão não-linear, a dose letal necessária para controlar 50% e 80% da população (DL50 e DL80) e o fator de resistência (FR). Os resultados demonstraram que apenas um biótipo de Tubarão-SC atendeu todos os critérios estatísticos e agronômicos e teve a resistência cruzada a inibidores da ACCase confirmada. Nas duas gerações observou-se que o FR foi superior a 1,0 e que a dose necessária para atingir o controle de 80% excedeu a dose máxima recomendada em bula. O nível de resistência foi superior para os herbicidas do grupo químico ariloxifenoxipropionatos, com FR maior que 7,0. Para o grupo químico ciclohexanodionas o FR foi menor que 5,0. RESUMO capimarroz capim Echinochloa crusgalli crus galli crus-galli cyhalofoppbutyl cyhalofop p butyl vegetação fatorial sendo (cyhalofop-p-butyl quizalofoppethyl quizalofop ethyl profoxydim ariloxifenoxipropionatos ciclohexanodionas) F F2 2 populações verdadeiras determinouse, determinouse determinou se, determinou-se nãolinear, nãolinear linear, linear não-linear 50 80 DL50 DL (DL5 DL80 FR. . (FR) TubarãoSC Tubarão SC observouse observou 10 1 0 1, bula 70 7 7,0 5 5,0 8 DL5 (DL DL8 (FR 7, 5,

Abstract Biotechnology offers solutions and opportunities to meet various societal demands, thereby contributing to significant scientific advancements. This study aimed to characterize the technological development of biotechnology in the healthcare sector in the state of Rio Grande do Sul, Brazil, from 2016 to 2022 by analyzing patents filed by and granted to public and private Higher Education institutions. For data collection, a quantitative exploratory approach was employed using statistical methods and a patent analysis of institutions in the patent database of the Brazilian National Institute of Industrial Property (INPI), focusing on patents related to the healthcare field. Data were collected in October, November, and December. A total of 580 patent records were collected from the INPI, belonging to Sections A and C of the International Patent Classification (IPC) related to educational institutions. Furthermore, this study highlighted that higher education institutions have a higher number of patents in the healthcare field. These results provide an understanding of the strategic areas for technological development in biotechnology in Rio Grande do Sul, Brazil. demands advancements Sul Brazil 201 202 collection INPI , (INPI) field October November December 58 IPC (IPC Furthermore 20 (INPI 5 2

Abstract Since the 1970s, maternal corticosteroid therapy has been used successfully to induce labor. This allows for better monitoring of parturients and provision of first aid to neonates, improving neonatal viability, as this treatment induces maturation in a variety of fetal tissues, thereby reducing morbidity and mortality. Although the effects of corticosteroids are well known, few studies have investigated the influence of this therapy in Santa Inês sheep. This study aimed to evaluate the efficacy of dexamethasone at two doses (8 and 16 mg) to induce lambing in Santa Inês ewes at 145 days of gestation and assess its effects on neonatal vitality. For this study, 58 ewes raised in an extensive system were investigated. Pregnancy was confirmed after artificial insemination at a set time or after controlled mounting. Ewes were separated into three groups: an untreated control group (G1: 0 mg) and groups treated with two doses of dexamethasone (G2: 8 mg and G3: 16 mg). In total, 79 lambs were born. Their vitality was assessed based on their Apgar score, weight, temperature, and postnatal behavior. SAS v9.1.3 (SAS Institute, Cary, NC) was used to analyze data, considering a 5% significance level for all analyses. The births in the induced groups occurred 48.4 ± 22.1 h after induction, while the ewes that underwent non-induced labor gave birth 131.96 ± 41.9 h after placebo application (p < 0.05), confirming the efficacy of dexamethasone to induce and synchronize labor. The induced and non-induced neonates had similar Apgar scores, temperatures, weights, and postnatal behavioral parameters (p > 0.05). This study showed that inducing labor in Santa Inês ewes at 145 days of gestation with a full (16 mg) or half dose (8 mg) of dexamethasone is an effective technique and does not compromise neonate vitality. 1970s s viability tissues mortality known sheep ( 1 14 5 mounting G1 G (G1 G2 (G2 G3 mg. . total 7 born score weight temperature behavior v913 v v9 3 v9.1. Institute Cary NC data analyses 484 48 4 48. 221 22 22. induction noninduced non 13196 131 96 131.9 419 41 9 41. p 0.05, 005 0.05 , 05 0.05) scores temperatures weights 0.05. (1 (G v91 v9.1 2 1319 13 131. 00 0.0 v9. 0.

ABSTRACT: One of the greatest challenges in poultry production is maintaining intestinal mucosal barrier integrity and gut microbiota balance. Safe alternative antimicrobials that can regulate the microbial community through animal feed have been the subject of research in poultry production. This study evaluated the effect of Mentha piperita and Melaleuca alternifolia essential oils (EOs) on the gut microbiome and morphometry of broiler quails under normal feeding conditions. The gut microbiome was studied using a completely randomized design consisting of 4 treatments, namely control, bacitracin zinc, and the Eos M. piperita and M. alternifolia, with 8 repetitions and 7 quails per treatment, totaling 224 quails from 1 to 42 days old. The intestinal contents of the slaughtered quails were collected to evaluate the gut microbiome profile of their digestive tract. Gut morphometry was analyzed using a completely randomized factorial design, with four experimental rations for three intestinal sections (4x3) and five replications. The variables studied were villus surface area and height, crypt depth, villus height to cryptdepth ratio (VH:CD), villus-crypt ratio (V:C), villus width to height ratio (VW:H), and height of the intestinal epithelium and musculature. M. alternifolia (50 mg/kg of feed) in the diet of broiler quails improved gut morphometry, similar to the results obtained with bacitracin zinc. This EO also altered the gut microbiome of quails and reduced pathogenic bacterial diversity. ABSTRACT balance EOs (EOs conditions treatments control zinc M treatment 22 old tract 4x3 x (4x3 replications depth VHCD, VHCD VH CD , (VH:CD) villuscrypt VC, VC V C (V:C) VWH, VWH VW H (VW:H) musculature 50 (5 mgkg mg kg diversity 2 4x (4x (VH:CD (V:C (VW:H 5 (

RESUMO: Um dos maiores desafios na produção de aves é manter a integridade da barreira da mucosa intestinal e o equilíbrio da microbiota intestinal. Antimicrobianos alternativos seguros, que podem regular a comunidade microbiana através da alimentação animal, têm sido objeto de pesquisa na produção avícola. O objetivo deste estudo foi avaliar o efeito dos óleos essenciais (OEs) Mentha piperita e Melaleuca alternifolia no microbioma intestinal e na morfometria de codornas de corte em condições normais de alimentação. O microbioma intestinal foi estudado em delineamento inteiramente casualizado com 4 tratamentos: controle, bacitracina zinco e os OEs M. piperita e M. alternifolia, com 8 repetições, por tratamento,com sete codornas totalizando 224 aves no período de um a 42 dias. O conteúdo intestinal das codornas abatidas foi coletado para avaliar o perfil do microbioma intestinal de seu trato digestivo. A morfometria intestinal foi estudada usando um delineamento fatorial inteiramente casualizado, consistindo de quatro rações experimentais para três secções intestinais (4x3), com cinco repetições. As variáveis estudadas foram área das vilosidades intestinais, altura das vilosidades intestinais, profundidade da cripta intestinal, relação entre a altura das vilosidades e a profundidade das criptas, relação cripta e vilosidades intestinais, relação largura e altura das vilosidades intestinais, altura do epitélio intestinal e altura da musculatura intestinal. A utilização do OE M. alternifolia (50 mg/kg de ração) na dieta de codornas de corte resultou em melhora da morfometria intestinal, semelhante aos resultados obtidos com bacitracina zinco. Além disso, alterou o microbioma intestinal de codornas e reduziu a diversidade bacteriana patogênica. RESUMO seguros animal avícola (OEs tratamentos controle M repetições tratamentocom tratamento 22 dias digestivo 4x3, 4x3 x , (4x3) criptas 50 (5 mgkg mg kg ração disso patogênica 2 4x (4x3 5 ( (4x

A new class of deep eutectic solvents (DES) was used in the extraction of levodopa (L-dopa) present in Mucuna cinerea, which has been termed “green” or “designer” solvents, with notable productive and economic/environmental benefits. The seeds of Mucuna cinerea were prepared and submitted to extraction with heating and agitation in a solvent mixture of DES with citric acid, urea, or glycerol. The extracts were analyzed by high performance liquid chromatography (HPLC) which confirmed the efficiency of DES in extracting L-dopa. These extractions were carried out to determine the L-dopa extracts in DES with regard to the induction of cellular response activity, demonstrating the synergy between L-dopa and DES. The DES-glycerol extract exhibited a higher proliferative activity than commercial L-dopa after 24 h of treatment. The human glandular kallikrein-1 gene (hGK3) demonstrated higher expression in the treatment with the DES-urea, while the G protein-coupled receptor kinase-6 gene (GRK6) showed higher expression for all extracts compared to commercial L-dopa, with a higher value obtained for DES glycerol, followed by DES urea extract. The DES extraction method is therefore promising and unprecedented, confirming its possible use in the replacement of expensive solvents, supporting the use of ecologically viable DES in the extractions of other plant species. (DES Ldopa L dopa (L-dopa green “green designer “designer economicenvironmental economic environmental benefits acid glycerol HPLC (HPLC Ldopa. dopa. DESglycerol 2 kallikrein1 kallikrein 1 kallikrein- hGK3 hGK (hGK3 DESurea, DESurea DES-urea proteincoupled protein coupled kinase6 kinase 6 kinase- GRK6 GRK (GRK6 Ldopa, dopa, unprecedented species (hGK (GRK

Abstract This study aimed to estimate the prevalence and extent of bleeding on probing and calculus in 12-year-old schoolchildren of Quito, Ecuador, and evaluate the associated factors. We conducted an epidemiological survey with a representative sample of 1,100 12-year-old schoolchildren from public schools in the urban area of Quito, Ecuador. We assessed the periodontal health using the Community Periodontal Index (CPI). The prevalence and extent of the periodontal condition was based on the presence of at least one site with bleeding on probing (BOP), and the presence of dental calculus was also evaluated. We used univariate and multiple multilevel Poisson regression analyses to verify the association between the independent variables and the number of sextants with BOP and calculus. The prevalence of BOP and calculus was 92% and 69.9%, respectively. The adjusted mean of the affected sextants was 4.3 and 2.2 for BOP and calculus, respectively. The mother’s schooling and malocclusion were associated with the number of sextants with bleeding. The mother’s schooling and dental caries experience were associated with calculus. Gingival bleeding and the presence of dental calculus are highly prevalent in 12-year-old schoolchildren from Quito. Gingival bleeding is associated with maternal education and malocclusion, and dental calculus is associated with maternal education and dental caries. 12yearold yearold 12 year old Quito Ecuador factors 1100 1 100 1,10 CPI. CPI . (CPI) BOP, , (BOP) evaluated 92 699 69 9 69.9% respectively 43 4 3 4. 22 2 2. mothers mother s 110 10 1,1 (CPI (BOP 6 69.9 11 1, 69.

ABSTRACT Background: Safety data on the yellow fever vaccine 17DD in People Living with HIV (PLWH) are limited. This study explored the occurrence of post-vaccination 17DD viremia and the kinetics of hematological and liver laboratorial parameters in PLWH and HIV-uninfected participants [HIV(-) controls]. Methods: We conducted a secondary analysis of a longitudinal interventional trial (NCT03132311) study that enrolled PLWH and HIV(-) controls to receive a single 17DD dose and were followed at 5, 30 and 365 days after vaccination in Rio de Janeiro, Brazil. 17DD viremia (obtained throughreal-time PCR and plaque forming units' assays), hematological (neutrophils, lymphocytes and platelets counts) and liver enzymes (ALT and AST) results were assessed at baseline and Days 5 and 30 post-vaccination. Logistic regression models explored factors associated with the odds of having positive 17DD viremia. Linear regression models explored variables associated with hematological and liver enzymes results at Day 5. Results: A total of 202 PLWH with CD4 > 200 cells/μL and 68 HIV(-) controls were included in the analyses. 17DD viremia was found in 20.0 % of the participants and was twice more frequent in PLWH than in HIV(-) controls (22.8% vs. 11.8 %, p-value < 0.001). Neutrophils, lymphocytes and platelets counts dropped at Day 5 and returned to baseline values at Day 30. 17DD viremia was associated with lower nadir of lymphocytes and platelets at Day 5. ALT levels did not increase post-vaccination and were not associated with 17DD viremia. Conclusions: 17DD was safe and well-tolerated in PLWH with CD4 > 200 cells/μL. Post-vaccination viremia was more frequent in PLWH than in controls. Transient and self-limited decreases in lymphocytes and neutrophils occurred early after vaccination. 17DD viremia was associated with lower lymphocytes and platelets nadir after vaccination. We did not observe elevations in ALT after 17DD vaccination. Background DD (PLWH limited postvaccination post HIVuninfected uninfected [HIV(- . controls] Methods NCT03132311 NCT (NCT03132311 HIV(- 3 36 Janeiro Brazil obtained throughrealtime throughreal time units assays, assays , assays) neutrophils, (neutrophils AST postvaccination. Results 20 CD cellsμL cells μL 6 analyses 0 20. 22.8% 228 22 8 (22.8 vs 118 11 11. pvalue p value 0.001. 0001 0.001 001 0.001) Neutrophils Conclusions welltolerated well tolerated Postvaccination Post selflimited self [HIV( NCT0313231 (NCT0313231 HIV( 2 22.8 (22. 1 000 0.00 00 [HIV NCT031323 (NCT031323 22. (22 0.0 NCT03132 (NCT03132 (2 0. NCT0313 (NCT0313 ( NCT031 (NCT031 NCT03 (NCT03 NCT0 (NCT0 (NCT

RESUMEN Objetivo Estimar la prevalencia y analizar factores asociados a la inadecuada capacidad para el trabajo entre los agentes comunitarios de salud (ACSs). Métodos Estudio transversal realizado con ACS, de julio a octubre de 2018, en Montes Claros, Minas Gerais, Brasil; se investigó la capacidad de trabajo y factores sociodemográficos, ocupacionales y clínicos; las razones de prevalencia (RP) con intervalos de confianza del 95% (IC95%) se calcularon mediante regresión de Poisson. Resultados De los 675 ACS, el 25,8 % (IC95% 22,7;29,2) presentó capacidad laboral inadecuada; tiempo de servicio superior a 5 años (RP = 1,64; IC95% 1,24;2,18), mal estado de salud (RP = 2,10; IC95% 1,56;2,83), síntomas depresivos (RP = 1,98; IC95% 1,54;2,55) y trastornos de la voz (RP = 1,85; IC95% 1,26;2,73) estaban relacionados con el evento. Conclusión Hubo alta prevalencia de capacidad inadecuada para el trabajo, asociada a factores laborales y clínicos. ACSs. ACSs . (ACSs) ACS 2018 Claros Gerais Brasil sociodemográficos clínicos RP 95 IC95 IC Poisson 67 258 25 8 25, (IC95 22,729,2 227292 22,7 29,2 22 7 29 2 22,7;29,2 1,64 164 1 64 1,242,18, 124218 1,24 2,18 , 24 18 1,24;2,18) 2,10 210 10 1,562,83, 156283 1,56 2,83 56 83 1,56;2,83) 1,98 198 98 1,542,55 154255 1,54 2,55 54 55 1,54;2,55 1,85 185 85 1,262,73 126273 1,26 2,73 26 73 1,26;2,73 evento (ACSs 201 9 IC9 6 (IC9 729 22,729, 22729 227 22, 292 29, 22,7;29, 1,6 16 242 1,242,18 12421 124 1,2 218 2,1 1,24;2,18 21 562 1,562,83 15628 156 1,5 283 2,8 1,56;2,83 1,9 19 542 1,542,5 15425 154 255 2,5 1,54;2,5 1,8 262 1,262,7 12627 126 273 2,7 1,26;2,7 20 (IC 72 22,729 2272 22,7;29 1, 1,242,1 1242 12 2, 1,24;2,1 1,562,8 1562 15 28 1,56;2,8 1,542, 1542 1,54;2, 1,262, 1262 27 1,26;2, 22,72 22,7;2 1,242, 1,24;2, 1,562, 1,56;2, 1,542 1,54;2 1,262 1,26;2 22,7; 1,242 1,24;2 1,562 1,56;2 1,54; 1,26; 1,24; 1,56;

ABSTRACT Objective To estimate the prevalence and analyze factors associated with inadequate work ability among community health workers (CHWs). Methods This was a cross-sectional study conducted with CHWs, from July to October 2018, in Montes Claros, state of Minas Gerais, Brazil; work ability, sociodemographic, occupational, and clinical factors were investigated; prevalence ratios (PRs) with 95% confidence intervals (95%CI) were calculated using Poisson regression. Results Of the 675 CHWs, 25.8% (95%CI 22.7;29.2) showed inadequate work ability; length of service greater than five years (PR = 1.64; 95%CI 1.24;2.18), poor health status (PR = 2.10; 95%CI 1.56;2.83), depressive symptoms (PR = 1.98; 95%CI 1.54;2.55) and voice disorders (PR = 1.85; 95%CI 1.26;2.73) were associated with the event. Conclusion There was a high prevalence of inadequate work ability, associated with occupational and clinical factors. CHWs. CHWs . (CHWs) crosssectional cross sectional 2018 Claros Gerais Brazil sociodemographic investigated PRs (PRs 95 95CI CI regression 67 258 25 8 25.8 22.729.2 227292 22.7 29.2 22 7 29 2 22.7;29.2 PR 1.64 164 1 64 1.242.18, 124218 1.24 2.18 , 24 18 1.24;2.18) 2.10 210 10 1.562.83, 156283 1.56 2.83 56 83 1.56;2.83) 1.98 198 98 1.542.55 154255 1.54 2.55 54 55 1.54;2.55 1.85 185 85 1.262.73 126273 1.26 2.73 26 73 1.26;2.73 event (CHWs 201 9 6 25. 729 22.729. 22729 227 22. 292 29. 22.7;29. 1.6 16 242 1.242.18 12421 124 1.2 218 2.1 1.24;2.18 21 562 1.562.83 15628 156 1.5 283 2.8 5 1.56;2.83 1.9 19 542 1.542.5 15425 154 255 2.5 1.54;2.5 1.8 262 1.262.7 12627 126 273 2.7 1.26;2.7 20 72 22.729 2272 22.7;29 1. 1.242.1 1242 12 2. 1.24;2.1 1.562.8 1562 15 28 1.56;2.8 1.542. 1542 1.54;2. 1.262. 1262 27 1.26;2. 22.72 22.7;2 1.242. 1.24;2. 1.562. 1.56;2. 1.542 1.54;2 1.262 1.26;2 22.7; 1.242 1.24;2 1.562 1.56;2 1.54; 1.26; 1.24; 1.56;

RESUMO Objetivo Estimar a prevalência e analisar fatores associados à capacidade inadequada para o trabalho entre agentes comunitários de saúde (ACS). Métodos Estudo transversal realizado com ACS, no período de julho a outubro de 2018, em Montes Claros, Minas Gerais, Brasil; foi investigada a capacidade para o trabalho, fatores sociodemográficos, laborais e clínicos; razões de prevalência (RPs) com intervalos de confiança de 95% (IC95%) foram calculadas por regressão de Poisson. Resultados Dos 675 ACS estudados, 25,8% (IC95% 22,7;29,2) apresentaram capacidade inadequada para o trabalho; tempo de serviço superior a cinco anos (RP = 1,64; IC95% 1,24;2,18), percepção do estado de saúde ruim (RP = 2,10; IC95% 1,56;2,83), sintomas depressivos (RP = 1,98; IC95% 1,54;2,55) e distúrbios da voz (RP = 1,85; IC95% 1,26;2,73) estiveram associados ao evento. Conclusão Houve prevalência elevada de capacidade inadequada para o trabalho, associada a fatores laborais e clínicos. ACS. . (ACS) 2018 Claros Gerais Brasil sociodemográficos clínicos RPs (RPs 95 IC95 IC Poisson 67 estudados 258 25 8 25,8 (IC95 22,729,2 227292 22,7 29,2 22 7 29 2 22,7;29,2 RP 1,64 164 1 64 1,242,18, 124218 1,24 2,18 , 24 18 1,24;2,18) 2,10 210 10 1,562,83, 156283 1,56 2,83 56 83 1,56;2,83) 1,98 198 98 1,542,55 154255 1,54 2,55 54 55 1,54;2,55 1,85 185 85 1,262,73 126273 1,26 2,73 26 73 1,26;2,73 evento (ACS 201 9 IC9 6 25, (IC9 729 22,729, 22729 227 22, 292 29, 22,7;29, 1,6 16 242 1,242,18 12421 124 1,2 218 2,1 1,24;2,18 21 562 1,562,83 15628 156 1,5 283 2,8 5 1,56;2,83 1,9 19 542 1,542,5 15425 154 255 2,5 1,54;2,5 1,8 262 1,262,7 12627 126 273 2,7 1,26;2,7 20 (IC 72 22,729 2272 22,7;29 1, 1,242,1 1242 12 2, 1,24;2,1 1,562,8 1562 15 28 1,56;2,8 1,542, 1542 1,54;2, 1,262, 1262 27 1,26;2, 22,72 22,7;2 1,242, 1,24;2, 1,562, 1,56;2, 1,542 1,54;2 1,262 1,26;2 22,7; 1,242 1,24;2 1,562 1,56;2 1,54; 1,26; 1,24; 1,56;