ABSTRACT: The aim of this study was to evaluate the vital signs related with different dental treatments, and correlate with demographic data and participants’ anxiety level. This is a prospective clinical study with 60 participants, divided into 3 groups of dental procedures: (1) restorative treatment, (2) extractions and biopsies, and (3) gingival treatment. A level of anxiety questionnaire before dental procedure proposed by Corah’s Dental Anxiety Scale was collected. Respiratory rate, systolic and diastolic pressure, temperature and oxygenation were measured before, during and after the procedures. 31 (51.7 %) women and 29 (48.3 %) men were included, with mean age of 41.75 years old. Most participants (50 %) were classified as very little anxious. Diastolic pressure before the procedure was higher for slightly anxious patients when compar ed with very little anxious patients (p=0.028). Systolic pressure before, during and after the procedure was higher for participan ts above 40 years old (p=0,001). Heart rate (p=0,050) and temperature (p=0,041) was higher before the restorative treatment. Anxiety can promote changes in vital signs in the dental environment. Vital signs, sex, age and level of anxiety do influence the blood pressure at different clinical moments. Dental procedures have association with variations in temperature, heart and respiratory rate.

RESUMEN: El objetivo de este estudio fue evaluar los signos vitales relacionados con diferentes tratamientos dentales y correlacionarlos con datos demográficos y el nivel de ansiedad de los participantes. Este es un estudio clínico prospectivo con 60 participantes, divididos en 3 grupos de procedimientos dentales: (1) tratamiento restaurador, (2) extracciones y biopsias, y (3) tratamiento gingival. Se recogió un cuestionario de nivel de ansiedad antes del procedimiento odontológico propuesto por la Escala de Ansiedad Dental de Corah. Se midieron la frecuencia respiratoria, la presión sistólica y diastólica, la temperatura y la oxigenación antes, durante y después de los procedimientos. Se incluyeron 31 (51,7 %) mujeres y 29 (48,3 %) hombres, con edad media de 41,75 años. La mayoría de los participantes (50 %) fueron clasificados como muy poco ansiosos. La presión diastólica antes del procedimiento fue mayor en los pacientes ligeramente ansiosos en comparación con los pacientes muy poco ansiosos(p=0,028). La presión sistólica antes, durante y después del procedimiento fue mayor para los participantes mayores de 40 años (p=0,001). La frecuencia cardíaca (p=0,050) y la temperatura (p=0,041) fueron mayores antes del tratamiento restaurativo. La ansiedad puede promover cambios en los signos vitales en el entorno dental. Los signos vitales, el sexo, la edad y el nivel de ansiedad sí influyen en la presión arterial en los diferentes momentos clínicos. Los procedimientos dentales tienen asociación con variaciones de temperatura, frecuencia cardíaca y respiratoria.

Abstract Introduction Smell is one of the senses of the human body, and it can be affected by several factors, such as viral infections, traumatic brain injury, iatrogenesis, smoking, and neurodegenerative and systemic diseases. Objectives The main goal of the present study is to describe the epidemiology of olfactory disorders in Rio Grande do Norte (RN). More specifically, to determine the prevalence of olfactory dysfunction and to identify the main risk factors related to these dysfunctions in the state's population. Methods A total of 180 volunteers living in the RN underwent the Connecticut Clinical Research Center (CCCRC) smell test and a clinical and demographic questionnaire. Results A total of 58.89% of the patients presented normosmia and 87.78% were classified as having between normal and mild hyposmia. A statistically significant relationship was found between worse performance in the test and nasal surgery (p = 0.041) and the subjective feeling of not having an accurate sense of smell (p = 0.006 on the right nostril). There was no statistical relationship between the olfactory status and the report of coronavirus disease 2019 (COVID-19) infection (p = 0.254). Conclusion The occurrence of altered sense of smell in our study was different from that reported in other studies that used the same test. The relationship with COVID-19 was not clear. body infections injury iatrogenesis smoking diseases RN. . (RN) specifically states state s population 18 CCCRC (CCCRC questionnaire 5889 58 89 58.89 8778 87 78 87.78 hyposmia p 0.041 0041 0 041 0006 006 0.00 nostril. nostril nostril) 201 COVID19 COVID 19 (COVID-19 0.254. 0254 0.254 254 0.254) COVID-1 clear (RN 1 588 5 8 58.8 877 7 87.7 0.04 004 04 000 00 0.0 20 COVID1 (COVID-1 025 0.25 25 COVID- 58. 87. 0. 2 (COVID- 02 0.2 (COVID

Abstract Brazil has been recording a decrease in the coverage rates of primary vaccines since 2016. Several factors can influence this scenario, including access to immunizers and people’s hesitation to take vaccines. The exchange of information about the topic increased considerably during the COVID-19 pandemic. In this study, we carried out an analysis of stories about vaccines shown on Fantástico, TV Globo, and on Domingo Espetacular, Record TV, from March 2020 to August 2021, aiming to investigate how both TV shows - both broadcast on Sundays and focused on infotainment, but with different editorial lines and audiences - presented the theme and provided visibility to it. The corpus analysis gathered 110 stories, a total of 10 hours and 43 minutes, submitted to content analysis. In general, the TV shows stimulated the population to trust the vaccines, but exaggerations and imprecisions were observed on the show on Record TV. 2016 scenario peoples people s COVID19 COVID 19 COVID-1 pandemic study Fantástico Globo Espetacular 202 2021 infotainment it 11 1 4 minutes general 201 COVID1 COVID- 20 2

Resumo Desde 2016, o Brasil tem registrado queda nas taxas de cobertura das principais vacinas. São múltiplos os fatores que podem ter influência sobre esse cenário, incluindo o acesso aos imunizantes e a hesitação das pessoas em se vacinar. Durante a pandemia de covid-19, a circulação de informações sobre o tema aumentou de forma considerável. Nesse contexto, realizamos um estudo de matérias sobre vacinas exibidas no Fantástico, da TV Globo, e no Domingo Espetacular, da Record TV, entre março de 2020 e agosto de 2021, a fim de investigar como os programas - ambos dominicais e de infotainment, porém com linhas editoriais e públicos-alvo distintos - apresentaram e deram visibilidade à temática. O corpus de análise reuniu 110 matérias, totalizando 10 horas e 43 minutos, que foram submetidas à análise de conteúdo. De modo geral, as revistas eletrônicas televisivas estimularam a população a confiar nas vacinas, mas exageros e imprecisões foram vistos no programa da Record TV. 2016 cenário vacinar covid19, covid19 covid 19, 19 covid-19 considerável contexto Fantástico Globo Espetacular 202 2021 infotainment públicosalvo públicos alvo temática 11 1 4 minutos conteúdo geral 201 covid1 covid-1 20 covid- 2

ABSTRACT Tomato (Solanum lycopersicum L.), a globally significant species, faces substantial economic losses due to pest insects. However, exploiting dwarf germplasm for pest resistance, particularly the UFU MC TOM1 lineage, remains underexplored. The objectives of this study were to select backcross populations from dwarf tomato plants through direct and indirect selection and to elucidate whether there are consequences in resistance level as backcross generations progress aiming at a genetic background of interest. Backcross populations 1, 2, and 3 of dwarf tomato plants were obtained. In the conducted experiment, featuring 20 treatments and four repetitions in a randomized block design, we assessed foliar injuries and herbivory through image analysis. Additionally, we quantified the content of acylsugars, conducted chromatographic analysis, and analyzed the metabolomic profile in the leaflets. Promisingly, the UFU 13_1 dwarf plant population showed potential for enhancing genetic improvement programs targeting pest insect resistance. Moreover, the progression of backcross generations yielded varied resistance levels, likely influenced by inheritance patterns and acylsugar content. The UFU MC TOM1 line, distinguished by its high acylsugar content, exhibited robust resistance against both the tomato leafminer (Tuta absoluta Meyrick 1917) and the leafminer (Liriomyza huidobrensis Blanchard). Furthermore, our analysis revealed the expression of metabolites in the UFU MC TOM1 lineage, potentially linked to various biotic and abiotic stress responses. These findings offer promising prospects for leveraging the dwarf tomato variety, UFU MC TOM1, in genetic improvement programs aimed at combating pest insects in tomatoes. Solanum L., L L. , L.) species However TOM lineage underexplored interest 1 2 obtained experiment design Additionally acylsugars leaflets Promisingly 131 13 13_ Moreover levels line Tuta 1917 Liriomyza Blanchard. Blanchard . Blanchard) Furthermore responses variety tomatoes 191 19

Abstract Brazil has been recording a decrease in the coverage rates of primary vaccines since 2016. Several factors can influence this scenario, including access to immunizers and people’s hesitation to take vaccines. The exchange of information about the topic increased considerably during the COVID-19 pandemic. In this study, we carried out an analysis of stories about vaccines shown on Fantástico, TV Globo, and on Domingo Espetacular, Record TV, from March 2020 to August 2021, aiming to investigate how both TV shows - both broadcast on Sundays and focused on infotainment, but with different editorial lines and audiences - presented the theme and provided visibility to it. The corpus analysis gathered 110 stories, a total of 10 hours and 43 minutes, submitted to content analysis. In general, the TV shows stimulated the population to trust the vaccines, but exaggerations and imprecisions were observed on the show on Record TV.

Resumo Desde 2016, o Brasil tem registrado queda nas taxas de cobertura das principais vacinas. São múltiplos os fatores que podem ter influência sobre esse cenário, incluindo o acesso aos imunizantes e a hesitação das pessoas em se vacinar. Durante a pandemia de covid-19, a circulação de informações sobre o tema aumentou de forma considerável. Nesse contexto, realizamos um estudo de matérias sobre vacinas exibidas no Fantástico, da TV Globo, e no Domingo Espetacular, da Record TV, entre março de 2020 e agosto de 2021, a fim de investigar como os programas - ambos dominicais e de infotainment, porém com linhas editoriais e públicos-alvo distintos - apresentaram e deram visibilidade à temática. O corpus de análise reuniu 110 matérias, totalizando 10 horas e 43 minutos, que foram submetidas à análise de conteúdo. De modo geral, as revistas eletrônicas televisivas estimularam a população a confiar nas vacinas, mas exageros e imprecisões foram vistos no programa da Record TV.

Abstract Tomato cultivation is globally significant, demanding enhanced yields and biotic stress resilience for sustainability. Dwarf plant utilization in tomato genetic enhancement offers underexplored benefits. Yet, Santa Cruz dwarf tomato germplasm is unavailable. This study evaluated genetic dissimilarity, agronomic potential, and acylsugar content of Santa Cruz dwarf tomato plants across three successive backcrossings. Twelve advanced backcrossing populations (BC) and a commercial control (cv. Kada) were assessed, totaling 15 treatments. Agronomic traits and acylsugar content were measured, and analysis techniques were applied to assess genetic dissimilarity and backcrossing superiority. BC3 populations UFU-Sci#8, UFU-Sci#6, UFU-Sci#5, and UFU-Sci#1 excelled. Dwarf plants predominantly exhibited high leaflet acylsugar levels, suggesting potential for acquisition of hybrid with pest resistance. Notably, UFU MC TOM1 (dwarf plant) displayed significant glycine and L-serine presence, associated with various biotic stresses. These findings unveil the promising creation of dwarf Santa Cruz tomato hybrids with a broad spectrum of resistance. sustainability benefits Yet unavailable backcrossings BC (BC cv. cv (cv Kada assessed 1 treatments measured superiority UFUSci#8, UFUSci8 UFUSci Sci#8, Sci 8 UFU-Sci#8 UFUSci#6, UFUSci6 Sci#6, 6 UFU-Sci#6 UFUSci#5, UFUSci5 Sci#5, 5 UFU-Sci#5 UFUSci#1 UFUSci1 Sci#1 UFU-Sci# excelled levels resistance Notably TOM Lserine L serine presence stresses UFUSci#8 Sci8 Sci#8 UFUSci#6 Sci6 Sci#6 UFUSci#5 Sci5 Sci#5 UFUSci# Sci1 Sci# UFU-Sci

Abstract Background There is clinical and radiological overlap among demyelinating diseases. However, their pathophysiological mechanisms are different and carry distinct prognoses and treatment demands. Objective To investigate magnetic resonance imaging (MRI) features of patients with myelin-oligodendrocyte glycoprotein associated disease (MOGAD), antibody against aquaporin-4(AQP-4)-immunoglobulin G-positive neuromyelitis optica spectrum disorder (AQP4-IgG NMOSD), and double-seronegative patients. Methods A cross-sectional retrospective study was performed to analyze the topography and morphology of central nervous system (CNS) lesions. Two neuroradiologists consensually analyzed the brain, orbit, and spinal cord images. Results In total, 68 patients were enrolled in the study (25 with AQP4-IgG-positive NMOSD, 28 with MOGAD, and 15 double-seronegative patients). There were differences in clinical presentation among the groups. The MOGAD group had less brain involvement (39.2%) than the NMOSD group (p = 0.002), mostly in the subcortical/juxtacortical, the midbrain, the middle cerebellar peduncle, and the cerebellum. Double-seronegative patients had more brain involvement (80%) with larger and tumefactive lesion morphology. In addition, double-seronegative patients showed the longest optic neuritis (p = 0.006), which was more prevalent in the intracranial optic nerve compartment. AQP4-IgG-positive NMOSD optic neuritis had a predominant optic-chiasm location, and brain lesions mainly affected hypothalamic regions and the postrema area (MOGAD versus AQP4-IgG-positive NMOSD, p= 0 .013). Furthermore, this group had more spinal cord lesions (78.3%), and bright spotty lesions were a paramount finding to differentiate it from MOGAD (p = 0.003). Conclusion The pooled analysis of lesion topography, morphology, and signal intensity provides critical information to help clinicians form a timely differential diagnosis. diseases However demands MRI (MRI myelinoligodendrocyte myelin oligodendrocyte , (MOGAD) aquaporin4AQP4immunoglobulin aquaporinAQPimmunoglobulin aquaporin 4 AQP immunoglobulin Gpositive G positive AQP4IgG AQPIgG AQP4 IgG NMOSD) doubleseronegative double seronegative crosssectional cross sectional CNS (CNS orbit images total 6 25 (2 AQP4IgGpositive AQPIgGpositive 2 1 . patients) groups 39.2% 392 39 (39.2% p 0.002, 0002 0.002 002 0.002) subcorticaljuxtacortical subcortical juxtacortical subcortical/juxtacortical midbrain peduncle cerebellum Doubleseronegative Double 80% 80 (80% addition 0.006, 0006 0.006 006 0.006) compartment opticchiasm chiasm location .013. 013 .013 .013) Furthermore 78.3%, 783 78.3% 78 3 (78.3%) 0.003. 0003 0.003 003 0.003) diagnosis ( IgGpositive 39.2 (39.2 000 0.00 00 8 (80 01 .01 78.3 7 (78.3% 39. (39. 0.0 (8 .0 78. (78.3 (39 0. (78. (3 (78 (7

Resumo Antecedentes Há sobreposição clínica e radiológica entre as doenças desmielinizantes. No entanto, seus mecanismos fisiopatológicos são diferentes e apresentam prognósticos e demandas de tratamento distintos. Objetivo Investigar as características de imagens de RM dos pacientes com doença associada à glicoproteína de oligodendrócito de mielina (MOGAD), a doenças do espectro da neuromielite óptica positivas para antiaquaporina-4 imunoglobulina G (AQP4-IgG NMOSD), e pacientes duplamente soronegativos. Métodos Estudo retrospectivo e transversal para analisar as características e frequência das lesões do sistema nervoso central (SNC). Dois neurorradiologistas avaliaram consensualmente as imagens do cérebro, das órbitas e da medula espinhal. Resultados Ao todo, foram incluídos 68 pacientes(25 com AQP4-IgG NMOSD, 28 com MOGAD e 15 duplo-soronegativos). Há diferenças na apresentação clínica entre os grupos. O grupo MOGAD demonstrou menor frequência de comprometimento do cérebro (39.2%) comparado com o AQP4-IgG NMOSD (p = 0.002), com predomínio da distribuição das lesões nas regiões subcortical/justacortical, mesencéfalo, pedúnculos cerebelares médios e cerebelo. O grupo duplo-soronegativo demonstrou maior frequência de comprometimento do cérebro (80%), com lesões de maiores dimensões e com morfologia tumefeita, além de neurite óptica com maior extensão (p = 0.006). O grupo AQP4-IgG NMOSD demonstrou neurite óptica com predomínio na região óptico-quiasmática e as lesões encefálicas acometeram predominantemente as regiões hipotalâmica e área postrema (MOGAD versus AQP4-IgG NMOSD p = 0.013). Além disso, foram observadas mais lesões na medula espinhal (78.3%) e a presença da “bright spotty lesion” foi um achado primordial para a sua diferenciação com os pacientes MOGAD (p = 0.003). Conclusão A análise pormenorizada das características das lesões por RM dos pacientes com doenças desmielinizantes imunomediadas fornece informações fundamentais que auxiliam os médicos no diagnóstico diferencial em um momento oportuno. entanto distintos MOGAD, , (MOGAD) antiaquaporina4 antiaquaporina 4 antiaquaporina- AQP4IgG AQPIgG AQP4 IgG AQP NMOSD) soronegativos SNC. SNC . (SNC) todo 6 pacientes25 25 pacientes(2 2 1 duplosoronegativos. duplosoronegativos duplo duplo-soronegativos) grupos 39.2% 392 39 (39.2% 0.002, 0002 0.002 0 002 0.002) subcorticaljustacortical subcortical justacortical subcortical/justacortical mesencéfalo cerebelo duplosoronegativo soronegativo 80%, 80 80% (80%) tumefeita 0.006. 0006 0.006 006 0.006) ópticoquiasmática óptico quiasmática 0.013. 0013 0.013 013 0.013) disso 78.3% 783 78 3 (78.3% bright lesion 0.003. 0003 0.003 003 0.003) oportuno (SNC pacientes2 pacientes( duplo-soronegativos 39.2 (39.2 000 0.00 00 8 (80% 001 0.01 01 78.3 7 (78.3 39. (39. 0.0 (80 78. (78. (39 0. (8 (78 (3 ( (7

Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a rare and severe inflammatory disorder of the central nervous system (CNS). It is strongly associated with anti-aquaporin 4 antibodies (AQP4-IgG), and it mainly affects young women from non-white ethnicities. However, ~ 5 to 10% of all cases have onset during childhood. Children and adolescents share the same clinical, radiologic, and laboratory presentation as adults. Thus, the same NMOSD diagnostic criteria are also applied to pediatric-onset patients, but data on NMOSD in this population is still scarce. In seronegative pediatric patients, there is a high frequency of the antibody against myelin oligodendrocyte glycoprotein (MOG-IgG) indicating another disease group, but the clinical distinction between these two diseases may be challenging. Three drugs (eculizumab, satralizumab, and inebilizumab) have been recently approved for the treatment of adult patients with AQP4-IgG-positive NMOSD. Only satralizumab has recruited adolescents in one of the two pivotal clinical trials. Additional clinical trials in pediatric NMOSD are urgently required to evaluate the safety and efficacy of these drugs in this population. (NMOSD CNS. CNS . (CNS) antiaquaporin anti aquaporin AQP4IgG, AQP4IgG AQPIgG AQP4 IgG , AQP (AQP4-IgG) nonwhite non white ethnicities However 10 childhood radiologic adults Thus pediatriconset scarce MOGIgG MOG (MOG-IgG group challenging eculizumab, eculizumab (eculizumab inebilizumab AQP4IgGpositive AQPIgGpositive positive (CNS (AQP4-IgG 1 IgGpositive

Resumo O espectro da neuromielite óptica (ENMO) é uma rara e grave doença inflamatória do sistema nervoso central (SNC), fortemente associada ao anticorpo anti-aquaporina 4 (AQP4-IgG) e que afeta preferencialmente mulheres jovens de etnias não-caucasianas. No entanto, aproximadamente de 5 a 10% de todos os casos se iniciam na infância. Crianças e adolescentes compartilham as mesmas características clínicas, radiológicas e laboratoriais dos adultos. Além disso, o mesmo critério diagnóstico de ENMO é aplicado para pacientes com início na infância. No entanto, dados da população pediátrica são escassos. Em pacientes pediátricos soronegativos, existe uma alta frequência de positividade ao anticorpo contra a glicoproteína na mielina do oligodendrócito (MOG-IgG), indicando outra patologia; porém, a distinção clínica entre as duas doenças é desafiadora. Três medicações (eculizumabe, inebilizumabe e satralizumabe) foram recentemente aprovadas para pacientes adultos com AQP4-IgG. Apenas um dos ensaios pivotais do satralizumabe recrutou adolescentes. Novos ensaios clínicos em pacientes pediátricos com ENMO são necessários para avaliar a segurança e eficácia destas drogas nesta população. (ENMO SNC, SNC , (SNC) antiaquaporina anti aquaporina AQP4IgG AQPIgG AQP4 IgG AQP (AQP4-IgG nãocaucasianas. nãocaucasianas não caucasianas. caucasianas não-caucasianas entanto 10 infância clínicas disso escassos soronegativos MOGIgG, MOGIgG MOG (MOG-IgG) patologia porém desafiadora eculizumabe, eculizumabe (eculizumabe AQP4IgG. IgG. AQP4-IgG (SNC 1 (MOG-IgG

Abstract: Introduction: Complaints about medical malpractice are frequent. Therefore, investigating how the medical student formation is made concerning the ethical and legal aspects, can contribute to its improvement. Objective: To evaluate and compare the level of knowledge of medical students from a university about ethical and legal aspects of the profession, based on their formation in the disciplines of the related axis (Medical Ethics and Bioethics; Legal Medicine and Deontology/Medical Forensics and Good Practice). Method: Cross-sectional study carried out through the application of an online questionnaire (August-November/2020) based on the Code of Medical Ethics (CME) and the Code of Ethics for Medical Student- 10 sociodemographic and 12 objective questions (Topics: “Professional Confidentiality”, “Medical student’s Interpersonal Relations”, “Medical Publicity”, “Relations with Patients and Families”, “Human Rights”, “Fundamental Principles”, “Medical Activity” and “Telemedicine”). A total of 116 students were evaluated at the start, middle and end of the medical course. The Kruskal-Wallis and Dunn tests were used for comparisons. The Chi-Square and Fisher’s exact tests were used for the association of categorical variables. Results: The performance increased throughout the course, with statistical significance between the average number of correct answers in the 1st, 6th and 10th/12th periods: 5.1; 6.7 and 7.8, (p-value <0.001). The analysis by thematic blocks, on the other hand, did not show a statistical association of correct answers with progress in the medical course (p-value >0.05) for broad-reaching topics and development of competences from the basic cycle, such as “Medical Publicity”, “Relations with Patients and Families”, “Telemedicine” and “Medical Student’s Interpersonal Relations” - with emphasis on the student’s limitations in providing care. As for topics that required competences inherent to the disciplines of the ethical-legal axis, this association was identified (p-value <0.05), as follows: “Professional Confidentiality”, “Human Rights”, “Fundamental Principles”, “Medical Activity” and “Medical Student’s Interpersonal Relations” - specifically on the use of electronics. Finally, the highest percentage of correct answers (95.7%) is associated with “Medical Student’s Interpersonal Relations”, with an emphasis on the student’s limitations. While the lowest rates were found in “Professional Confidentiality” (18.1%), “Medical Activity” (33.6%) and “Human Rights” (25%)”. Conclusion: There is an association between the medical formation proposed by the ethical-legal axis, and the effective increase of the medical student’s level of knowledge concerning the ethical-legal aspects of the profession. Abstract Introduction frequent Therefore improvement Objective profession Bioethics DeontologyMedical Deontology Practice. Practice . Practice) Method Crosssectional Cross sectional AugustNovember/2020 AugustNovember2020 AugustNovember August November/2020 November 2020 (August-November/2020 CME (CME Student 1 Topics (Topics Professional Confidentiality, Confidentiality , s Relations, Relations Publicity, Publicity Publicity” Families, Families Families” Human Rights, Rights Fundamental Principles, Principles Principles” Activity Telemedicine. Telemedicine “Telemedicine”) 11 start KruskalWallis Kruskal Wallis comparisons ChiSquare Chi Square Fishers Fisher variables Results 1st st th 10th12th thth 10th 12th periods 5.1 51 5 67 6 7 6. 78 8 7.8 pvalue p value <0.001. 0001 <0.001 0 001 <0.001) blocks hand >0.05 005 05 broadreaching broad reaching cycle “Telemedicine Students care ethicallegal <0.05, <0.05 <0.05) follows electronics Finally 95.7% 957 95 (95.7% 18.1%, 181 18.1% 18 (18.1%) 33.6% 336 33 (33.6% 25%. 25 25% (25%)” Conclusion AugustNovember/202 AugustNovember202 November2020 November/202 202 (August-November/202 5. 7. 000 <0.00 00 >0.0 <0.0 95.7 9 (95.7 18.1 (18.1% 33.6 3 (33.6 2 (25%) AugustNovember/20 AugustNovember20 November202 November/20 20 (August-November/20 >0. <0. 95. (95. 18. (18.1 33. (33. (25% AugustNovember/2 AugustNovember2 November20 November/2 (August-November/2 >0 <0 (95 (18. (33 (25 AugustNovember/ November2 November/ (August-November/ > < (9 (18 (3 (2 (August-November ( (1

Resumo: Introdução: A literatura refere como frequentes denúncias sobre má prática médica. Logo, a investigação de como é feita a formação do acadêmico de Medicina, no contexto ético-legal, pode contribuir para sua melhoria. Objetivo: Este estudo teve como objetivos avaliar e comparar o conhecimento de acadêmicos de uma faculdade de Medicina sobre aspectos ético-legais da profissão, a partir de sua formação nas disciplinas do eixo relacionado (“Ética Médica e Bioética”, “Medicina Legal” e “Deontologia/Perícia Médica e Boas Práticas”). Método: Trata-se de um estudo transversal com aplicação de questionário (agosto-novembro/2020) estruturado no Código de Ética Médica e Código de Ética do Estudante de Medicina - dez questões sociodemográficas e 12 objetivas (temas: “sigilo profissional”, “relações interpessoais do estudante de Medicina”, “publicidade médica”, “relação com pacientes e familiares”, “direitos humanos”, “princípios fundamentais”, “atividade médica” e “telemedicina”). Avaliaram-se 116 alunos: início, meio (durante curso do eixo ético-legal) e final da graduação. Para comparação, utilizaram-se os testes de Kruskal-Wallis e de Dunn. Para associação entre variáveis categóricas, adotaram-se o qui-quadrado e o teste exato de Fisher. Resultado: Identificou-se desempenho crescente com o avançar dos períodos, com diferença estatística entre as médias de acertos do primeiro, sexto e décimo/12°: 5,1; 6,7; e 7,8, (valor-p < 0,001). Já a análise por blocos temáticos não apontou associação estatística dos acertos com avançar na graduação (valor-p > 0,05) para temas de amplo alcance e desenvolvimento das competências desde o ciclo básico, como “publicidade médica”, “relação com pacientes e familiares”, “telemedicina” e “relações interpessoais do estudante de Medicina” - com ênfase em limitações do acadêmico no atendimento. Já para temas que exigiam competências inerentes às disciplinas do eixo ético-legal, encontrou-se tal associação (valor-p < 0,05), sendo: “sigilo profissional”, “direitos humanos”, “princípios fundamentais”, “atividade médica” e “relações interpessoais do estudante de medicina” - especificamente sobre uso de eletrônicos. Por fim, o maior percentual de acertos (95,7%) associa-se às “relações interpessoais do estudante de Medicina”, com ênfase nas limitações do acadêmico. Já as menores taxas apresentaram-se em “sigilo profissional” (18,1%), “atividade médica” (33,6%) e “direitos humanos” (25%)”. Conclusão: Existe associação entre a formação proposta pelo eixo ético-legal e aumento efetivo do nível de conhecimento no acadêmico de Medicina sobre os aspectos ético-legais da profissão. Resumo Introdução médica Logo éticolegal, éticolegal ético legal, legal melhoria Objetivo éticolegais legais profissão Bioética, Bioética , Bioética” Legal Deontologia/Perícia DeontologiaPerícia Deontologia Perícia Práticas. Práticas . Práticas”) Método Tratase Trata se agostonovembro/2020 agostonovembro2020 agostonovembro agosto novembro/2020 novembro 2020 (agosto-novembro/2020 1 (temas sigilo profissional, profissional relações publicidade médica, relação familiares, familiares familiares” direitos humanos, humanos princípios fundamentais, fundamentais fundamentais” atividade telemedicina. telemedicina “telemedicina”) Avaliaramse Avaliaram 11 alunos início durante comparação utilizaramse utilizaram KruskalWallis Kruskal Wallis Dunn categóricas adotaramse adotaram quiquadrado qui quadrado Fisher Resultado Identificouse Identificou períodos primeiro décimo/12° décimo12 décimo 5,1 51 5 6,7 67 6 7 78 8 7,8 valorp valor p 0,001. 0001 0,001 0 001 0,001) 0,05 005 05 básico “telemedicina atendimento encontrouse encontrou 0,05, sendo medicina eletrônicos fim 95,7% 957 95 (95,7% associase associa apresentaramse apresentaram 18,1%, 181 18,1% 18 (18,1%) 33,6% 336 33 (33,6% 25%. 25 25% (25%)” Conclusão Práticas” agostonovembro/202 agostonovembro202 novembro2020 novembro/202 202 (agosto-novembro/202 décimo/12 décimo1 5, 6, 7, 000 0,00 00 0,0 95,7 9 (95,7 18,1 (18,1% 33,6 3 (33,6 2 (25%) agostonovembro/20 agostonovembro20 novembro202 novembro/20 20 (agosto-novembro/20 décimo/1 0, 95, (95, 18, (18,1 33, (33, (25% agostonovembro/2 agostonovembro2 novembro20 novembro/2 (agosto-novembro/2 décimo/ (95 (18, (33 (25 agostonovembro/ novembro2 novembro/ (agosto-novembro/ (9 (18 (3 (2 (agosto-novembro ( (1

ABSTRACT Science museums are dynamic spaces in which scientific culture is associated with the culture of the visiting subjects and which have the potential to evoke memories in their visitors in the form of memories and affective recollections. In this study, we investigated the memories of the experience of eight adult visitors two years after their visit to the Museu da Natureza, in the Serra da Capivara National Park Piauí. The methodology involved semi-structured interviews, including the verbalization of spontaneous memories and the use of the stimulated recall method. The results showed several memory events of episodic (chronological recall of events) and semantic nature (associated with facts, concepts, words and their meanings), emotional involvement and reinterpretations of the experience previously lived in a science museum. recollections study Natureza Piauí semistructured semi structured interviews method chronological facts concepts meanings, meanings , meanings) museum

RESUMO Os museus de ciência são espaços dinâmicos em que a cultura científica se associa com a cultura dos sujeitos visitantes e que têm o potencial de evocar memórias em seus frequentadores em forma de lembranças e recordações afetivas. Neste estudo investigamos as memórias da experiência de oito visitantes adultos dois anos após a visita que realizaram ao Museu da Natureza, localizado no Parque Nacional Serra da Capivara, Piauí. A metodologia envolveu entrevista semiestruturada, incluindo a verbalização de lembranças espontâneas e utilização do método da lembrança estimulada. Os resultados evidenciaram diversos eventos de memórias de caráter episódico (lembrança cronológica de eventos) e semântico (associadas a fatos, conceitos, palavras e seus significados), envolvimento emocional e reinterpretações sobre a experiência anteriormente vivida em um museu de ciência. afetivas Natureza Capivara Piauí semiestruturada estimulada associadas fatos conceitos significados, significados , significados)

Resumen: En este artículo analizamos las percepciones sobre las mujeres negras en la ciencia, a partir de conversaciones sobre la película Figuras Ocultas. La película retrata la trayectoria de tres científicas negras de la NASA, en el contexto de la segregación racial en los Estados Unidos en la década de 1960. Mediante el Análisis de Contenido, investigamos los comentarios en Letterboxd con el fin de identificar los significados producidos por los espectadores. Los resultados indican el predominio de comentarios que celebran el papel protagónico de la mujer negra, aunque refuerzan la apelación al mérito individual ante las asimetrías estructurales. También hay críticas al mantenimiento de estereotipos conservadores, como el del “salvador blanco”. Estas conversaciones revelan cruces interseccionales en la percepción pública de la ciencia y la relevancia de representaciones mediáticas más diversas de la actividad científica en términos de género y raza. Resumen Ocultas NASA 1960 Contenido espectadores negra estructurales conservadores salvador blanco. blanco . blanco” raza 196 19 1

Abstract: In this paper, we analyze perceptions about black women in science, based on conversations about the film Hidden Figures. The movie portrays the trajectory of three black female NASA scientists, in the context of racial segregation in the USA in the 1960s. Through Content Analysis, we investigate comments on Letterboxd, in order to identify meanings produced by viewers. The results indicate the predominance of comments that celebrate the leading role of black women, even though they reinforce the appeal to the individual merit in the face of structural asymmetries. There are also criticisms of the maintenance of conservative stereotypes, such as the “white savior”. These conversations reveal intersectional crossings in the public perception of science and the relevance of more diverse media representations of scientific activity in terms of gender and race. Abstract paper Figures scientists 1960s s Analysis Letterboxd viewers asymmetries stereotypes white savior. savior . savior” race

Resumo: Neste artigo, analisamos percepções acerca de mulheres negras na ciência a partir das conversações sobre o filme Estrelas Além do Tempo. A produção retrata a trajetória de três cientistas negras da NASA, no contexto de segregação racial dos EUA nos anos 1960. Por meio da Análise de Conteúdo, investigamos comentários na rede social Letterboxd com o objetivo de identificar sentidos articulados pelos espectadores. Os resultados indicam o predomínio de comentários que celebram o protagonismo de mulheres negras, porém reforçam o apelo ao mérito individual frente a assimetrias estruturais. Há ainda críticas à manutenção de estereótipos conservadores, como o “salvador branco”. Tais conversações desvelam atravessamentos interseccionais na percepção pública da ciência e a importância de representações midiáticas mais diversas da atividade científica em termos de gênero e raça. Resumo artigo Tempo NASA 1960 Conteúdo espectadores estruturais conservadores salvador branco. branco . branco” raça 196 19 1

Abstract Background Data on post-acute COVID-19 in autoimmune rheumatic diseases (ARD) are scarce, focusing on a single disease, with variable definitions of this condition and time of vaccination. The aim of this study was to evaluate the frequency and pattern of post-acute COVID-19 in vaccinated patients with ARD using established diagnosis criteria. Methods Retrospective evaluation of a prospective cohort of 108 ARD patients and 32 non-ARD controls, diagnosed with SARS-CoV-2 infection (RT-PCR/antigen test) after the third dose of the CoronaVac vaccine. Post-acute COVID-19 (≥ 4 weeks and > 12 weeks of SARS-CoV-2 symptoms) were registered according to the established international criteria. Results ARD patients and non-ARD controls, balanced for age and sex, had high and comparable frequencies of ≥ 4 weeks post-acute COVID-19 (58.3% vs. 53.1%, p = 0.6854) and > 12 weeks post-acute COVID-19 (39.8% vs. 46.9%, p = 0.5419). Regarding ≥ 4 weeks post-acute COVID-19, frequencies of ≥ 3 symptoms were similar in ARD and non-ARD controls (54% vs. 41.2%, p = 0.7886), and this was also similar in > 12 weeks post-acute COVID-19 (68.3% vs. 88.2%, p = 0.1322). Further analysis of the risk factors for ≥ 4 weeks post-acute COVID-19 in ARD patients revealed that age, sex, clinical severity of COVID-19, reinfection, and autoimmune diseases were not associated with this condition (p > 0.05). The clinical manifestations of post-acute COVID-19 were similar in both groups (p > 0.05), with fatigue and memory loss being the most frequent manifestations. Conclusion We provide novel data demonstrating that immune/inflammatory ARD disturbances after third dose vaccination do not seem to be a major determinant of post-acute COVID-19 since its pattern is very similar to that of the general population. Clinical Trials platform (NCT04754698). postacute post acute COVID19 COVID 19 COVID-1 (ARD scarce disease criteria 10 nonARD non SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- RTPCR/antigen RTPCRantigen RT PCR/antigen PCR antigen test vaccine Postacute Post ( 1 sex 58.3% 583 58 (58.3 vs 531 53 53.1% 0.6854 06854 0 6854 39.8% 398 39 8 (39.8 469 46 9 46.9% 0.5419. 05419 0.5419 . 5419 0.5419) COVID19, 19, 54% 54 (54 412 41 41.2% 0.7886, 07886 0.7886 , 7886 0.7886) 68.3% 683 68 (68.3 882 88 88.2% 0.1322. 01322 0.1322 1322 0.1322) reinfection 0.05. 005 0.05 05 0.05) 0.05, immuneinflammatory immune inflammatory population NCT04754698. NCT04754698 NCT (NCT04754698) COVID1 COVID- SARS-CoV RTPCR PCRantigen 58.3 5 (58. 53.1 0.685 0685 685 39.8 (39. 46.9 0541 0.541 541 (5 41.2 0788 0.788 788 68.3 6 (68. 88.2 0132 0.132 132 00 0.0 NCT0475469 (NCT04754698 58. (58 53. 0.68 068 39. (39 46. 054 0.54 41. 078 0.78 78 68. (68 88. 013 0.13 13 0. NCT047546 (NCT0475469 0.6 06 (3 0.5 07 0.7 7 (6 01 0.1 NCT04754 (NCT047546 NCT0475 (NCT04754 NCT047 (NCT0475 NCT04 (NCT047 NCT0 (NCT04 (NCT0 (NCT

ABSTRACT Autism Spectrum Disorder is not an adverse condition for cochlear implantation, but the goals and expectations about the effects on hearing and language outcomes are different from the group of children without other impairments. The objective of this study was to analyze the development of auditory and oral language skills of a child with autism who underwent early cochlear implantation surgery and was included in an auditory (re)habilitation program using the aural-oral method. There was no benefit from the device for the development of oral language, and the child was referred to another communicative method. After 2 years and 9 months using the cochlear implants, there was little benefit from the use of the device for the development of auditory skills, with the child evolving to recognize only his own name. The patient quit using the device after three years of its activation. impairments rehabilitation re habilitation auraloral aural method implants name activation

RESUMO O transtorno do espectro autista não é uma contraindicação para o implante coclear, mas as metas e expectativas sobre os efeitos nos resultados da audição e da linguagem são diferentes em relação ao grupo de crianças sem outros comprometimentos. O objetivo deste estudo foi analisar o desenvolvimento das habilidades auditivas e de linguagem falada de uma criança com transtorno do espectro autista submetida precocemente à cirurgia de implante coclear e inserida em um programa de (re)habilitação auditiva no método aurioral. Observou-se que não houve benefício do dispositivo para o desenvolvimento da linguagem falada, tendo a criança sido encaminhada para outro método comunicativo. Em 2 anos e 9 meses de uso do implante coclear, observou-se pouco benefício do uso do dispositivo para o desenvolvimento das habilidades auditivas, havendo a evolução para o reconhecimento somente do próprio nome. A criança deixou de fazer uso dos dispositivos após três anos da ativação. comprometimentos rehabilitação re habilitação aurioral Observouse Observou se comunicativo observouse observou nome ativação

ABSTRACT The Afrotropical Zaprionus Coquillett, 1902 (Diptera: Drosophilidae) has gained visibility since the 1990s due to the geographic expansion of Zaprionus indianus Gupta, 1970. More recently, a second species, Zaprionus tuberculatus Malloch, 1932, invaded regions outside its original African regions, causing economic concerns, particularly in Europe. In 2021, Z. tuberculatus was captured for the first time in the Americas, specifically in urban parks, and preserved fragments of the Brazilian Cerrado, causing concerns about the competition with native drosophilids. Here we report the occurrence of Z. tuberculatus 900 km from its first record in urban and rural areas of Viçosa, MG, but not in forest fragments. Considering the great capacity for dispersion and the potential of Z. tuberculatus to compete with native drosophilids species, as well as the potential harm to fruit production when co-occurring with Drosophila suzukii (Matsumura, 1931), further studies would be necessary to monitor this invasion and create mechanisms to control it. Coquillett 190 Diptera (Diptera Drosophilidae s Gupta 1970 recently species Malloch 1932 Europe 2021 Z Americas parks Cerrado 90 Viçosa MG cooccurring co occurring Matsumura, Matsumura (Matsumura 1931, 1931 , 1931) it 19 197 193 202 9 1 20 2