Caffeine (CAF) and nicotine (NIC) are emerging contaminants and are among the most consumed substances in the world, making it crucial to monitor these contaminants. In this work, an alternative electrolyte, 2-hydroxyethylammonium acetate (2HEAA) was used for the development of an electroanalytical method for determination and quantification of CAF and NIC, simultaneously, using differential pulse voltammetry (DPV). The system with the 2HEAA electrolyte was characterized by cyclic voltammetry and electrochemical impedance spectroscopy, and the DPV parameters were optimized for the best conditions. The method was validated from a calibration curve obtained which showed limit of detection (LOD) of 0.82 and 6.26 μmol L 1 and limit of quantification (LOQ) of 2.73 and 20.8 μmol L-1 for CAF and NIC, respectively. In the precision analyses, values lower than 10% of relative standard deviation were obtained. In the presence of concomitant inorganic and organic species, the system proved to be selective in the determination of analytes. The method was used to determine the analytes in fortified samples (river water, synthetic urine and commercial milk), obtaining recoveries between 87.25 and 111.40%. The 2HEAA demonstrated high efficiency as an alternative electrolyte with good signal-to-noise ratio, increased analytical sensitivity of the method, in addition to presenting low cost and fast electrolyte preparation. (CAF NIC (NIC world work 2hydroxyethylammonium hydroxyethylammonium 2 HEAA (2HEAA simultaneously DPV. . (DPV) spectroscopy conditions LOD (LOD 082 0 82 0.8 626 6 26 6.2 LOQ (LOQ 273 73 2.7 208 20 8 20. L1 L- respectively analyses 10 species river water milk, milk , milk) 8725 87 25 87.2 11140 111 40 111.40% signaltonoise signal noise ratio preparation (DPV 08 0. 62 6. 27 7 2. 872 87. 1114 11 4 111.40 111.4 111.

Abstract Humans are exposed to natural compounds such as phytoestrogens primarily through diet and supplements. These compounds promote health by alleviating the symptoms and illnesses associated with menopause and arthritis. Diosgenin (DSG) occurs naturally in plants such as Dioscorea villosa (DV) and binds to estrogen receptors, so it may have similar effects to this hormone, including against arthritis. Thus, we investigated the effect of chronic treatment with dry extract of DV and its phytoestrogen DSG on ovariectomized mice with arthritis. We found that dry extract of Dioscorea villosa (DV) contains the phytoestrogen diosgenin (DSG) in its composition. Furthermore, arthritic mice treated with DV and DSG showed reduced neutrophil accumulation in the articular cartilage. Also, the dry extract of DV administered orally (v.o) did not alter the leukocyte count in the joints or promote changes in the reproductive tract. However, DSG altered these parameters, with possible beneficial effects by reducing symptoms related to reproductive aging. Thus, oral treatment with dry extract of DV and subcutaneous (s.c) treatment with DSG showed promise by acting against inflammation caused by arthritis and reducing symptoms in the reproductive tract due to menopause. supplements (DSG (DV receptors hormone Thus composition Furthermore cartilage Also v.o vo v o (v.o However parameters aging s.c sc s c (s.c

Abstract: The use of the ellipsoidal heights of a vessel for measuring the tide allows the diminution of uncertainties of sounding reduction in hydrographic surveys. In this article, the Precise Point Positioning (PPP) and Post-Processing Kinematic (PPK) methods were evaluated by comparing them with data from a tide gauge station while the boat remained moored nearby. When traversing sounding lines, the PPK solution was used as a reference to validate the PPP solution. In all, 12 different periods of surveys were analyzed, distributed throughout the year 2021, in the Guanabara and Ilha Grande Bays, in Rio de Janeiro. The results showed that in comparison with the tide station, when the vessel was moored, the PPK was able to fulfill the strictest criteria (Exclusive Order) of the IHO (International Hydrographic Organization) in 100% of the surveys, while the PPP in 50%. Regarding the use of the PPK as a reference, with the boat both moored and sailing, the PPP met these criteria in 67% for Exclusive Order, 25% for Order 1A and 8% for the 1B. Reducing the vertical uncertainties of hydrographic surveys in shallow waters is useful for all marine and coastal vertical positioning applications, such as integrating terrestrial and marine vertical references. Abstract article (PPP PostProcessing Post Processing (PPK nearby lines 1 analyzed 2021 Bays Janeiro International Organization 100 50 50% sailing 67 25 A 8 1B B applications references 202 10 5 6 2 20

ABSTRACT Purpose: In glaucoma, initial visual field scotomas can be peripheral or central, whereas central scotomas are more severe and can disrupt daily activities. Individual anatomical features may influence the distribution of retinal nerve fibers and the starting site of visual field defects in glaucoma. In this study, we aimed to correlate myopia and hyperopia or anatomical variation of the disk-fovea angle with initial central or peripheral lesions in the visual field. Methods: This cross-sectional study included patients with primary open-angle glaucoma divided into a group of isolated central or peripheral scotomas in the visual field with MD > or equal to -6 dB, correlating with the degree of ametropia and anatomical variations, such as the disk-fovea angle. Results: We included 52 patients with glaucoma. Of 20 myopic patients, 6 (30%) had central scotomas, and 14 (70%) had peripheral scotomas. Of 32 hyperopic patients, 12 (37.5%) had central scotomas, and 20 (63.5%) had peripheral scotomas. Regarding the disk-fovea angle, 25 eyes had the disk-fovea angle of < -7°, with 9 (36%) eyes presenting with central scotoma, and 27 eyes presented with the disk-fovea angle of > -7°, with 9 (33.3%) eyes presenting with a central scotoma. Conclusion: This study showed an association between ametropia and scotomas on the perimetry in patients with glaucoma. Patients had a higher incidence of peripheral scotomas, but hyperopic patients had a greater number of central scotomas than myopic patients, and myopic patients had more peripheral scotomas than hyperopic patients. The disk-fovea angle was not correlated with scotomas in initial glaucoma. Purpose activities diskfovea disk fovea Methods crosssectional cross sectional openangle open - dB variations Results 5 2 30% 30 (30% 1 70% 70 (70% 3 37.5% 375 37 (37.5% 63.5% 635 63 (63.5% 7°, 7 -7° 36% 36 (36% scotoma 33.3% 333 33 (33.3% Conclusion (30 (70 37.5 (37.5 63.5 (63.5 7° -7 (36 33.3 (33.3 (3 (7 37. (37. 63. (63. 33. (33. ( (37 (63 (33 (6

RESUMO Objetivos: No glaucoma, os escotomas iniciais no campo visual podem ser periféricos ou centrais. Os escotomas centrais são mais graves e podem atrapalhar as atividades diárias. As características anatômicas individuais podem influenciar a distribuição das fibras nervosas da retina e o local inicial dos defeitos do campo visual no glaucoma. Nesse estudo buscamos correlacionar a miopia e a hipermetropia ou a variação anatômica do ângulo disco-fóvea com lesões iniciais centrais ou periféricos no campo visual. Métodos: Este foi um estudo transversal incluindo pacientes com glaucoma primário de ângulo aberto divididos em grupo de escotomas isolados central ou periférico no campo visual com MD > ou igual a -6 dB, correlacionando com o grau de ametropia e variações anatômicas como o ângulo disco fóvea. Resultados: Incluímos 52 pacientes com glaucoma. Dos 20 míopes, 6 (30%) apresentaram escotoma central e 14 (70%) escotoma periférico) e 32 olhos hipermetrópicos com 12 (37,5%) escotomas centrais e 20 (63,5%) escotomas periféricos. Sobre o ângulo disco fóvea, 25 olhos tiveram ângulo disco fóvea menor que -7º com 9 (36%) olhos apresentando escotoma central e 27 olhos com ângulo disco fóvea maior que -7º com 9 (33,3%) olhos apresentando escotoma central. Conclusão: Este estudo mostrou associação da ametropia e os escotomas na perimetria em pacientes com glaucoma. Pacientes apresentaram maior incidência de escotomas periféricos, porém hipermétropes apresentaram maior quantidade de escotoma central que os míopes e os míopes mais escotomas periféricos que os hipermetropes. O ângulo disco fóvea não foi correlacionado com escotomas na perimetria no glaucoma inicial. Objetivos diárias discofóvea Métodos - dB Resultados 5 2 30% 30 (30% 1 70% 70 (70% 3 37,5% 375 37 (37,5% 63,5% 635 63 (63,5% 7º º 36% 36 (36% 33,3% 333 33 (33,3% Conclusão hipermetropes (30 7 (70 37,5 (37,5 63,5 (63,5 (36 33,3 (33,3 (3 (7 37, (37, 63, (63, 33, (33, ( (37 (63 (33 (6

Abstract Background Brazil had high COVID-19 lethality/mortality with multiple social inequalities, where color/race was highly relevant, especially in Rio de Janeiro. Therefore, we hypothesize that COVID-19 hospitalized patients with a highly socially vulnerable background would have more significant in-hospital mortality. Objective To analyze the socioeconomic factors of social vulnerability and their association with COVID-19 mortality. Methods This work was a prospective study of 274 confirmed adult COVID-19 hospitalized patients in the University Hospital of Clementino Fraga Filho (HUCFF). The clinical features/blood chemistry information were collected from the clinical record. The ArcGIS Pro Software (Esri Gis mapping software, Redlands California-US) and a Python-based algorithm were used to determine in-app/in-map variable management relevance to the socioeconomic variables, inequity markers, and vulnerability. Our study also analyzed the transfers from other primary care institutions to our hospital in order to examine its potential delays in advanced medical care. Logistic regression and ROC curve were used to investigate in-hospital mortality for our statistical analysis. The significance level adopted in the statistical analysis was 5% Results: Male sex, total days of hospitalization, age, having more than three comorbidities, intensive care unit (ICU) admission, hemodialysis, and transfer from other hospitals showed statistical significance. Patients living in low-adequate households (p = 0.030) with high in-house individual agglomeration markers (p = 0.017) and transfers from another Primary Health Care (PHC) institution (p = 0.047) were associated with increased in-hospital mortality, with high ICU admission and mechanical ventilation. Conclusions In-hospital mortality due to COVID-19 was influenced by social individual background characteristics of vulnerability. Among other clinical parameters, these markers should be considered to predict the likelihood of complications related to the COVID-19 pandemic. COVID19 COVID 19 COVID-1 lethalitymortality lethality inequalities colorrace color race relevant Janeiro Therefore inhospital 27 HUCFF. HUCFF . (HUCFF) featuresblood features blood record Esri software CaliforniaUS California US California-US Pythonbased Python based inapp/inmap inappinmap app/in map app variables 5 Results sex hospitalization age comorbidities (ICU hemodialysis lowadequate low adequate p 0.030 0030 0 030 inhouse house 0.017 0017 017 PHC (PHC 0.047 0047 047 ventilation Inhospital In parameters pandemic COVID1 1 COVID- 2 (HUCFF inapp inmap appin 0.03 003 03 0.01 001 01 0.04 004 04 0.0 00 0.

Abstract Legal reserve areas (LRAs) are a fundamental part of the Brazilian conservation strategy, together with permanent preservation areas. The LRAs are intended to maintain biodiversity and can be managed sustainably. When these areas are home to ecosystems that depend on fire and grazing, such as native grasslands and savannas, management practices that are suitable for their conservation and for dealing with the effects of global climate change should be adopted. However, this subject is still poorly discussed in Brazil, and public policies are not clear on this matter. This review article describes the grassland and savanna ecosystems in Brazil, the legal aspects related to the management of LRAs, the current and future climate scenarios, and the relationship between climate and fire risk. It also presents a review about the use of fire and grazing in grassland and savanna ecosystems, the legal challenges related to their application in LRAs, and the use of geotechnologies to monitor these practices. The conclusion is that grazing and fire, as management tools, are adequate for LRA functions, as long as they are practiced in accordance with legal and scientifically based standards to avoid the negative effects of their incorrect use. (LRAs strategy sustainably savannas adopted However Brazil matter scenarios risk tools functions

Resumo As áreas de reserva legal (ARLs) são parte fundamental da estratégia brasileira de conservação, juntamente com as áreas de preservação permanente. As ARLs são destinadas à manutenção da biodiversidade e podem ser manejadas de forma sustentável. Quando essas áreas abrigam ecossistemas dependentes de fogo e pastejo, como os campos nativos e as savanas, devem ser adotadas práticas de manejo adequadas à sua conservação e ao enfrentamento dos efeitos das mudanças climáticas globais. No entanto, esse assunto ainda é pouco discutido no Brasil, e as políticas públicas não são claras a esse respeito. Este artigo de revisão descreve os ecossistemas campestres e savânicos no Brasil, os aspectos legais relacionados com o manejo das ARLs, os cenários climáticos atuais e futuros, e a relação entre clima e risco de incêndios. Também apresenta uma revisão sobre o uso do fogo e do pastejo em ecossistemas campestres e savânicos, os desafios legais relativos à sua aplicação nas ARLs e o uso de geotecnologias no monitoramento destas práticas. Conclui-se que o pastejo e o fogo, como instrumentos de manejo, são adequados às funções das ARLs, desde que praticados segundo normas legais e cientificamente embasadas para evitar os efeitos negativos do seu uso equivocado. (ARLs permanente sustentável savanas globais entanto Brasil respeito futuros incêndios Concluise Conclui se equivocado

Abstract The objective is to identify concepts, experiences, methods, and techniques in Popular Health, Environmental and Occupational Surveillance (VPSAT). This is an integrative review that used the descriptors: Community Participation, Public Health Surveillance, Environmental Health, and Occupational Health, using five databases: Virtual Health Library, EBSCOhost, Embase, Scopus and Web of Science. The review selected 15 studies, based on the inclusion criteria: surveillance experiences with community protagonism; and exclusion criteria: research without primary data and developed only by the health service. The theoretical and methodological bases of the studies were identified as citizen science, popular education, and environmental justice; experiences such as participatory mapping and monitoring; methods such as action research, ‘do-it-yourself’, and community-based research; and techniques such as “Photovoice” and Community Journal. Low-income urban communities, indigenous peoples, young individuals, and workers stand out as the protagonists. The recognition of the VPSAT as an important source of data and intervention by public health systems and academia contributes to making health surveillance more dialogic and effective. concepts VPSAT. . (VPSAT) descriptors Participation databases Library EBSCOhost Embase Science 1 criteria protagonism service science education justice monitoring ‘doityourself, doityourself ‘do it yourself , do ‘do-it-yourself’ communitybased Photovoice “Photovoice Journal Lowincome Low income communities peoples individuals protagonists effective (VPSAT ‘doityourself ‘do-it-yourself

Resumo Objetiva-se identificar concepções, experiências, métodos e técnicas em Vigilância Popular da Saúde, Ambiente e Trabalho (VPSAT). Trata-se de uma revisão integrativa com os descritores: participação da comunidade, vigilância em saúde, vigilância da saúde, saúde ambiental e saúde do trabalhador, envolvendo cinco bancos de dados: Biblioteca Virtual da Saúde, EBSCOhost, Embase, Scopus e Web Of Science. A revisão selecionou 15 estudos, a partir dos critérios de inclusão: experiências de vigilância com protagonismo comunitário; e exclusão: pesquisas sem dados primários e desenvolvidas apenas pelo serviço de saúde. Identificaram-se como bases teóricas e metodológicas dos estudos a ciência cidadã, educação popular e justiça ambiental; e experiências como mapeamentos e monitoramentos participativos; métodos como pesquisa-ação, “faça você mesmo” e investigação baseada na comunidade; e técnicas como “Photovoice” e Jornal Comunitário. Destacam-se as comunidades urbanas de baixa renda, indígenas, jovens e trabalhadores como protagonistas. O reconhecimento da VPSAT como importante fonte de dados e de intervenção pelos sistemas de saúde públicos e pela academia contribui para que a vigilância em saúde seja mais dialógica e efetiva. Objetivase Objetiva se concepções Saúde VPSAT. . (VPSAT) Tratase Trata descritores comunidade trabalhador EBSCOhost Embase Science 1 inclusão comunitário exclusão Identificaramse Identificaram cidadã participativos pesquisaação, pesquisaação pesquisa ação, ação pesquisa-ação faça mesmo Photovoice “Photovoice Comunitário Destacamse Destacam renda indígenas protagonistas efetiva (VPSAT

Resumo Objetiva-se identificar concepções, experiências, métodos e técnicas em Vigilância Popular da Saúde, Ambiente e Trabalho (VPSAT). Trata-se de uma revisão integrativa com os descritores: participação da comunidade, vigilância em saúde, vigilância da saúde, saúde ambiental e saúde do trabalhador, envolvendo cinco bancos de dados: Biblioteca Virtual da Saúde, EBSCOhost, Embase, Scopus e Web Of Science. A revisão selecionou 15 estudos, a partir dos critérios de inclusão: experiências de vigilância com protagonismo comunitário; e exclusão: pesquisas sem dados primários e desenvolvidas apenas pelo serviço de saúde. Identificaram-se como bases teóricas e metodológicas dos estudos a ciência cidadã, educação popular e justiça ambiental; e experiências como mapeamentos e monitoramentos participativos; métodos como pesquisa-ação, “faça você mesmo” e investigação baseada na comunidade; e técnicas como “Photovoice” e Jornal Comunitário. Destacam-se as comunidades urbanas de baixa renda, indígenas, jovens e trabalhadores como protagonistas. O reconhecimento da VPSAT como importante fonte de dados e de intervenção pelos sistemas de saúde públicos e pela academia contribui para que a vigilância em saúde seja mais dialógica e efetiva.

Abstract The objective is to identify concepts, experiences, methods, and techniques in Popular Health, Environmental and Occupational Surveillance (VPSAT). This is an integrative review that used the descriptors: Community Participation, Public Health Surveillance, Environmental Health, and Occupational Health, using five databases: Virtual Health Library, EBSCOhost, Embase, Scopus and Web of Science. The review selected 15 studies, based on the inclusion criteria: surveillance experiences with community protagonism; and exclusion criteria: research without primary data and developed only by the health service. The theoretical and methodological bases of the studies were identified as citizen science, popular education, and environmental justice; experiences such as participatory mapping and monitoring; methods such as action research, ‘do-it-yourself’, and community-based research; and techniques such as “Photovoice” and Community Journal. Low-income urban communities, indigenous peoples, young individuals, and workers stand out as the protagonists. The recognition of the VPSAT as an important source of data and intervention by public health systems and academia contributes to making health surveillance more dialogic and effective.

ABSTRACT Objective: To define the mathematical relationship between fructosamine levels and average glucose values. Subjects and methods: The study comprised laboratory data of 1,227 patients with type 1 or 2 diabetes mellitus. Fructosamine levels measured at the end of a 3-week period were compared against the average blood glucose levels of the previous 3 weeks. Average glucose levels were determined by the weighted average of the daily fasting capillary glucose results performed during the study period, and the plasma glucose measured in the same sample collected for fructosamine measurement. Results: In total, 9,450 glucose measurements were performed. Linear regression analysis between fructosamine levels and average glucose levels showed that for each 1.0 µmol/L increase in fructosamine level there was a 0.5 mg/dL increase in average glucose level, as estimated by the equation Mean glucose level = (0.5157 x Fructosamine) – 20. The coefficient of determination (r2 = 0.353492, p < 0.006881) allowed the calculation of the estimated average glucose based on fructosamine level. Conclusion: Our study demonstrated a linear correlation between fructosamine level and mean blood glucose level, suggesting that fructosamine levels can be a proxy for the average glucose level in assessing the metabolic control of patients with diabetes. Objective values methods 1227 227 1,22 mellitus 3week week weeks measurement Results total 9450 9 450 9,45 10 0 1. µmolL µmol L 05 5 0. mgdL mg dL 0.5157 05157 5157 (0.515 20 r2 r (r 0353492 353492 0.353492 0.006881 0006881 006881 Conclusion 122 22 1,2 945 45 9,4 0.515 0515 515 (0.51 035349 35349 0.35349 0.00688 000688 00688 12 1, 94 4 9, 0.51 051 51 (0.5 03534 3534 0.3534 0.0068 00068 0068 (0. 0353 353 0.353 0.006 0006 006 (0 035 35 0.35 0.00 000 00 ( 03 0.3 0.0

Abstract In Brazil, there is low coverage of sewage collection and treatment, a condition that is even more critical in smaller cities. One reason for this is the lack of resources for investment in conventional reactors. The present study therefore compared the costs of different treatment alternatives based on the average values of construction and operation present in the literature, the values of the price per square meter for land acquisition, electricity tariffs, and final sludge disposal by considering different operating times of wastewater treatment plants (WWTPs). This allowed inferences about the costs associated with the choice of the configuration of a municipal WWTP. Based on the scenarios studied, it was observed that the conventional systems evaluated are, in general, more costly, especially after several years of operation. However, the choice of these treatment units may be more interesting in scenarios with high cost per square metre and lower electricity rates or where there is no area availability. For smaller cities and with lower real estate pressure, the natural systems evaluated are more indicated due to the low total costs (construction and operation) and adequate pollutant-removal efficiencies. Brazil reactors literature acquisition tariffs WWTPs. WWTPs . (WWTPs) WWTP studied general costly However availability pressure pollutantremoval pollutant removal efficiencies (WWTPs

Resumo No Brasil, verifica-se baixa cobertura de coleta e tratamento de esgotos, condição que é ainda mais crítica em cidades de menor porte. Um dos motivos apontados é a falta de recursos para investimento em reatores convencionais. Assim, o presente trabalho objetivou comparar custos de diferentes alternativas de tratamento, tendo como base, valores médios de construção e operação, presentes na literatura, valores do preço do metro quadrado para aquisição de terra, de tarifas de energia elétrica e da disposição final do lodo, considerando diferentes tempos de funcionamento das Estações de Tratamentos de Esgotos (ETE), permitindo fazer inferências sobre os custos associados na escolha da configuração de uma ETE municipal. Com base nos cenários estudados, observou-se que os sistemas convencionais avaliados são, em geral, mais onerosos, sobretudo após vários anos de operação. A escolha dessas unidades de tratamento, no entanto, pode ser mais interessante em cenários com alto custo do metro quadrado e tarifas de energia elétrica mais baratas, ou onde não haja disponibilidade de área. Para cidades de menor porte, com menor pressão imobiliária, os sistemas naturais avaliados são mais indicados, pelos baixos custos totais (construção e operação) e adequadas eficiências de remoção de poluentes. Brasil verificase verifica se esgotos porte Assim operação literatura terra lodo ETE, , (ETE) municipal estudados observouse observou geral onerosos entanto baratas área imobiliária indicados poluentes (ETE

ABSTRACT Objective To assess the stage of the disease at the time of diagnosis. Methods Cross-sectional and descriptive study, using data obtained by searching the database of glaucoma patients in their first consultation, before the starting any treatment. Results 101 patients (177 eyes) were included. Only 31 (30.69%) patients reported a positive family history of glaucoma. We found 26% of the evaluated eyes with advanced perimetric alterations, ten eyes (5.8%) with vision worse than 20/400, of these, three patients had legal blindness in both eyes. Factors associated with glaucoma severity were advanced age and high IOP. Conclusion Knowledge of the situation in the initial diagnosis portrays the reality of glaucoma in our environment and predicts actions aimed at preventing blindness. Crosssectional Cross sectional study consultation treatment 10 177 (17 included 3 30.69% 3069 30 69 (30.69% 26 alterations 5.8% 58 5 8 (5.8% 20400 20 400 20/400 these IOP 1 17 (1 30.69 306 6 (30.69 2 5.8 (5.8 2040 40 20/40 ( 30.6 (30.6 5. (5. 204 4 20/4 30. (30. (5 20/ (30 (3

RESUMO Objetivo Avaliar o estágio do glaucoma no momento de seu diagnóstico. Métodos Estudo transversal e descritivo, usando dados obtidos por meio de consultas ao banco de dados de pacientes glaucomatosos atendidos em sua primeira consulta, antes da instituição de quaisquer tratamentos. Resultados Foram incluídos 101 pacientes (177 olhos). Apenas 31 (30,69%) deles referiam história familiar positiva para glaucoma. Encontraram-se 26% dos olhos avaliados com alterações perimétricas avançadas, dez olhos (5,8%) com visão pior que 20/400 e, destes, três pacientes apresentavam cegueira legal em ambos os olhos. Os fatores associados à gravidade do glaucoma foram idade avançada e pressão intraocular elevada. Conclusão O conhecimento da situação no diagnóstico inicial retrata a realidade do glaucoma em nosso meio e prediz ações visando à prevenção da cegueira. descritivo consulta tratamentos 10 177 (17 . olhos) 3 30,69% 3069 30 69 (30,69% Encontraramse Encontraram se 26 avançadas 5,8% 58 5 8 (5,8% 20400 20 400 20/40 destes elevada 1 17 (1 30,69 306 6 (30,69 2 5,8 (5,8 2040 40 20/4 ( 30,6 (30,6 5, (5, 204 4 20/ 30, (30, (5 (30 (3

RESUMO: Objetivo: Analisar a distribuição espacial e a tendência temporal da taxa de incidência de AIDS no Brasil no período de 2005 a 2020. Métodos: Estudo ecológico, temporal e espacial sobre os casos de AIDS no Brasil. Dados provenientes do Sistema de Informação de Agravos de Notificação do Departamento de Informática do Sistema Único de Saúde foram estratificados por ano do diagnóstico, região do país/municípios de residência e faixa etária (acima de 13 anos). Foram calculadas as taxas de incidência (TI) para a estimativa temporal por meio do modelo de joinpoint, bem como as taxas bayesianas empíricas espaciais (TBEE) para a distribuição espacial pelo estimador de densidade de Kernel. Resultados: A TI no Brasil no ano de 2020 foi de 17,69 casos para cada 100 mil habitantes. A tendência geral (2005–2020) foi de diminuição no Brasil (variação percentual anual — VPA=-2,0%), Sudeste (VPA=-4,4%) e Sul (VPA=-3,0%). O Norte (VPA=2,3%) demonstrou aumento, enquanto o Sudeste e Centro-oeste foram estacionários (p>0,05). O Brasil, Sudeste, Sul e Centro-oeste apresentaram tendência de diminuição na maioria das faixas etárias. O Nordeste e Norte apresentaram aumento nas faixas etárias de 13 a 29 anos e 13 a 24 anos, respectivamente. O estimador de Kernel demonstrou conglomerados com TBEE acima de 30/10 mil habitantes nos estados de Paraíba, Sergipe, Alagoas, Pernambuco, São Paulo, Minas Gerais, Pará, Rio Grande do Sul e Santa Catarina. Conclusão: O Brasil e as Regiões Sudeste e Sul apresentaram diminuição da TI, enquanto o Norte aumentou e o Nordeste e Centro-oeste foram estacionários. As Regiões Sudeste, Sul e Nordeste apresentaram os maiores conglomerados das TBEE.

ABSTRACT: Objective: To analyze the spatial distribution and the temporal trend of the AIDS incidence rate in Brazil from 2005 to 2020. Methods: This is an ecological, temporal, and spatial study on AIDS cases in Brazil. Data from the Notifiable Diseases Information System were stratified by year of diagnosis, region of the country/municipalities of residence, and age group (over 13 years). Incidence rates were calculated for temporal estimation using the Joinpoint model, as well as Spatial Empirical Bayes (SEB) for spatial distribution, using the Kernel density estimator. Results: The incidence rate in Brazil, in 2020, was 17.69 cases per 100 thousand inhabitants. The general trend (2005–2020) was decrease in Brazil (Annual Percent Change – APC=-2.0%), in the Southeast (APC=-4.4%) and South (APC=-3.0%) regions. The North (APC=2.3%) showed an increase trend, whereas the Southeast and Midwest regions were stationary (p>0.05). Brazil, Southeast, South, and Midwest regions showed a decrease trend in most age groups. The Northeast and North regions showed an increase in the age groups of 13–29 years and 13–24 years, respectively. The Kernel estimator showed clusters with SEB above 30/10 thousand inhabitants in the states of Paraíba, Sergipe, Alagoas, Pernambuco, São Paulo, Minas Gerais, Pará, Rio Grande do Sul, and Santa Catarina. Conclusion: Brazil, the Southeast, and South regions showed a decrease in the incidence rate, whereas the North region increased and the Northeast and Midwest regions were stationary. The Southeast, South, and Northeast regions presented the largest clusters of SEB.

ABSTRACT: Objective: To analyze the spatial distribution and the temporal trend of the AIDS incidence rate in Brazil from 2005 to 2020. Methods: This is an ecological, temporal, and spatial study on AIDS cases in Brazil. Data from the Notifiable Diseases Information System were stratified by year of diagnosis, region of the country/municipalities of residence, and age group (over 13 years). Incidence rates were calculated for temporal estimation using the Joinpoint model, as well as Spatial Empirical Bayes (SEB) for spatial distribution, using the Kernel density estimator. Results: The incidence rate in Brazil, in 2020, was 17.69 cases per 100 thousand inhabitants. The general trend (2005–2020) was decrease in Brazil (Annual Percent Change – APC=-2.0%), in the Southeast (APC=-4.4%) and South (APC=-3.0%) regions. The North (APC=2.3%) showed an increase trend, whereas the Southeast and Midwest regions were stationary (p>0.05). Brazil, Southeast, South, and Midwest regions showed a decrease trend in most age groups. The Northeast and North regions showed an increase in the age groups of 13–29 years and 13–24 years, respectively. The Kernel estimator showed clusters with SEB above 30/10 thousand inhabitants in the states of Paraíba, Sergipe, Alagoas, Pernambuco, São Paulo, Minas Gerais, Pará, Rio Grande do Sul, and Santa Catarina. Conclusion: Brazil, the Southeast, and South regions showed a decrease in the incidence rate, whereas the North region increased and the Northeast and Midwest regions were stationary. The Southeast, South, and Northeast regions presented the largest clusters of SEB.

RESUMO: Objetivo: Analisar a distribuição espacial e a tendência temporal da taxa de incidência de AIDS no Brasil no período de 2005 a 2020. Métodos: Estudo ecológico, temporal e espacial sobre os casos de AIDS no Brasil. Dados provenientes do Sistema de Informação de Agravos de Notificação do Departamento de Informática do Sistema Único de Saúde foram estratificados por ano do diagnóstico, região do país/municípios de residência e faixa etária (acima de 13 anos). Foram calculadas as taxas de incidência (TI) para a estimativa temporal por meio do modelo de joinpoint, bem como as taxas bayesianas empíricas espaciais (TBEE) para a distribuição espacial pelo estimador de densidade de Kernel. Resultados: A TI no Brasil no ano de 2020 foi de 17,69 casos para cada 100 mil habitantes. A tendência geral (2005–2020) foi de diminuição no Brasil (variação percentual anual — VPA=-2,0%), Sudeste (VPA=-4,4%) e Sul (VPA=-3,0%). O Norte (VPA=2,3%) demonstrou aumento, enquanto o Sudeste e Centro-oeste foram estacionários (p>0,05). O Brasil, Sudeste, Sul e Centro-oeste apresentaram tendência de diminuição na maioria das faixas etárias. O Nordeste e Norte apresentaram aumento nas faixas etárias de 13 a 29 anos e 13 a 24 anos, respectivamente. O estimador de Kernel demonstrou conglomerados com TBEE acima de 30/10 mil habitantes nos estados de Paraíba, Sergipe, Alagoas, Pernambuco, São Paulo, Minas Gerais, Pará, Rio Grande do Sul e Santa Catarina. Conclusão: O Brasil e as Regiões Sudeste e Sul apresentaram diminuição da TI, enquanto o Norte aumentou e o Nordeste e Centro-oeste foram estacionários. As Regiões Sudeste, Sul e Nordeste apresentaram os maiores conglomerados das TBEE.

ABSTRACT The objective of this research was to identify whether the use of exergames can help improve physical fitness through Burpee and analyse whether exergames can improve agility and spatial-temporal perception in young soccer players and non-players. This is a descriptive exploratory research with qualitative-quantitative data analysis. Participants were children (10.8 ± 1.8 years). For this sample, it was observed that exergames did not promote a significant increase in physical fitness (Group 1 × Group 2= 95%CI (-6.39–6.59), p> 1.00; Group 3 × Group 4= 95%CI (-1.27–3.47), p> 1.00). In contrast, exergames promoted a significant improvement in agility and spatiotemporal perception for group 2 (Agility Pre × Post: Z= -2.828; p= 0.05; Spatiotemporal perception Pre × Post: Z= -2.828; p= 0.05). We understand that exergames did not improve physical fitness in young soccer players and that they also did not provide improvements in agility or spatiotemporal perception. However, for the non-athlete public, there was a significant improvement in agility and spatial-temporal perception.

RESUMO O objetivo desta pesquisa foi identificar se a utilização do exergames pode auxiliar na melhora da aptidão física através do Burpee, como também, analisar se os exergames podem melhorar a agilidade e a percepção espaço-temporal em jovens jogadores de futebol e não jogadores. Esta pesquisa tem caráter exploratório descritivo com analise quali-quantitativa dos dados. Os participantes do estudo foram crianças (10,8± 1,8 anos). Para essa amostra, foi observado que o exergames não promoveu aumento significativo da aptidão física (Grupo 1 × Grupo 2= IC95% (-6,39–6,59), p> 1,00; Grupo 3 × Grupo 4= IC95% (-1,27–3,47), p> 1,00). Em contrapartida, o exergames promoveu melhora significativa da agilidade e da percepção espaço-temporal para o grupo 2 (Agilidade Pré × Pós: Z= -2,828; p= 0,05; Percepção espaço-temporal Pré × Pós: Z= -2,828; p= 0,05). Depreendemos que os exergames não proporciona melhora da aptidão física em jovens jogadores de futebol, e que também não proporcionou melhoras na agilidade ou na percepção espaço-temporal. Porém, para o público não atleta, houve melhora significativa para a agilidade e percepção espaço-temporal.

ABSTRACT BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has placed considerable psychological stress on frontline healthcare workers (HCWs). OBJECTIVE: To evaluate the prevalence of burnout syndrome among HCWs facing the COVID-19 outbreak. DESIGN AND SETTING: Cross-sectional study conducted in six public intensive care units (ICUs) in the city of Fortaleza, Brazil. METHODS: An online survey was conducted among HCWs to measure the three dimensions of burnout. RESULTS: A total of 62 physicians (23.4%), 65 nurses (24.5%), 58 nurse technologists (21.9%) and 80 physiotherapists (30.2%) completed the questionnaire. Nearly half of the participants (48.6%) had high levels of emotional exhaustion, and almost one-third of them (29.4%) had high levels of depersonalization. Low levels of professional efficacy were observed in 18.1% of the sample. The independent determinants of depersonalization burnout were age < 33 years (odds ratio, OR 2.03; 95% confidence interval, CI 1.15-3.56; P = 0.01) and female gender (OR 0.33; 95% CI 0.18-0.62; P = 0.01). Increased workload was associated with both depersonalization (OR 2.37; 95% CI 2.02-5.50; P = 0.04) and emotional exhaustion (OR 1.89; 95% CI 1.04-3.58; P = 0.030). CONCLUSION: The COVID-19 pandemic has had a great impact on the dimensions of depersonalization and emotional exhaustion. Consideration of these dimensions is important when designing future burnout prevention programs for frontline personnel.