Abstract This study aimed to analyze students’ and graduates’ perceptions regarding the use of Problem-Based Learning (PBL) in nurse education. This is a qualitative study that employs the comprehensive and interpretative approach proposed by Dialectical Hermeneutics. Four focus groups were conducted with the participation of 17 students and 16 graduates from a higher education institution that implements PBL in nurse education. The analysis of results allowed for the identification of five thematic categories: difficulty in adapting to the method; attainment of autonomy in one’s own learning; encouragement of clinical reasoning development; enhancement of communication and interpersonal relationships; and integration between theory and practice. It is evident that the use of PBL promotes alignment with the propositions of curriculum guidelines for nurse education by fostering the development of skills and competencies such as autonomy, communication, interpersonal relationships, and clinical reasoning through comprehensive and contextualized practices. However, students encounter challenges with the changes observed when introduced to PBL, which are overcome during the implementation process. ProblemBased Problem Based (PBL Hermeneutics 1 categories method ones one s learning relationships practice practices However process

Resumo Objetivou-se analisar a percepção de estudantes e egressos sobre a utilização da Aprendizagem Baseada em Problemas (ABP) na formação do enfermeiro. Trata-se de um estudo qualitativo que utiliza a modalidade compreensiva e interpretativa proposta pela Hermenêutica-Dialética. Realizaram-se quatro grupos focais com a participação de 17 estudantes e 16 egressos de uma instituição de ensino superior que aplica a ABP na formação de enfermeiros. A análise dos resultados permitiu a definição de cinco categorias temáticas: dificuldade de adaptação em relação ao método; conquista de autonomia sobre o próprio aprendizado; incentivo ao desenvolvimento do raciocínio clínico; aprimoramento da comunicação e das relações interpessoais e integração entre teoria e prática. Evidencia-se que a utilização da ABP favorece a aproximação com as proposições das diretrizes curriculares para a formação do enfermeiro por meio do desenvolvimento de habilidades e competências como autonomia, comunicação, relações interpessoais e raciocínio clínico mediante práticas integrais e contextualizadas. Entretanto, os estudantes enfrentam dificuldades com as mudanças observadas ao serem inseridos nela ABP, as quais são superadas no decorrer do processo de implementação. Objetivouse Objetivou se (ABP Tratase Trata HermenêuticaDialética. HermenêuticaDialética Hermenêutica Dialética. Dialética Hermenêutica-Dialética Realizaramse Realizaram 1 enfermeiros temáticas método aprendizado prática Evidenciase Evidencia contextualizadas Entretanto implementação

Abstract Background 5-Fluorouracil (5-FU) is a first-line drug to treat cutaneous field cancerization (CFC). There are few clinical trials with topical colchicine (COL). Objective To evaluate the effectiveness of 0.5% COL cream versus 5% 5-FU cream in the treatment of CFC. Method This was a randomized, open, self-controlled clinical trial. Forty-five patients (90 forearms), with three to ten actinic keratoses (AK) on each forearm, used 0.5% COL cream 2×/day for seven days on one forearm, and 5% 5-FU cream 2× /day, for 21 days, on the other forearm. The dosages were defined based on previous clinical trials for each drug. Adverse effects were evaluated after 14 days and outcomes after 90 days of inclusion. The primary outcome was complete AK clearance and the secondary outcomes were: partial clearance (≥50%), reduction in AK count, assessment of the Forearm Photoaging Scale (FPS), AK Severity Score (AKSS), and adverse effects. Results After 90 days, there was complete clearance of AK in 37% (95% CI 24%-49%) and partial clearance in 85% (95% CI 76%-93%) of the forearms treated with 5-FU,versus 17% (95% CI 7%-27%) and 78% (95% CI 66%-88%) for COL (p > 0.07). There was a percentage reduction of 75% in the AK count of the forearms treated with 5-FU (95% CI 66%-83%) and 64% in those treated with COL (95% CI 55%-72%). Regarding FPS and AKSS, there was improvement in both groups, with no difference regarding FPS (p = 0.654), and 5-FU superiority for AKSS (p = 0.012). Study limitations Single-center study. Conclusions 5-FU and COL are effective for treating CFC, with neither showing superiority regarding the reduction in AK counts. 5Fluorouracil Fluorouracil 5 5FU FU (5-FU firstline first line CFC . (CFC) COL. (COL) 05 0 0.5 randomized open selfcontrolled self controlled trial Fortyfive Forty five (9 forearms, , forearms) (AK forearm 2day day 2 /day 1 9 inclusion ≥50%, 50 ≥50% (≥50%) FPS, (FPS) (AKSS) 37 95% 95 (95 24%49% 2449 24% 49% 24 49 24%-49% 85 76%93% 7693 76% 93% 76 93 76%-93% 5FU,versus 5FUversus FUversus FU,versus 17 7%27% 727 7% 27% 7 27 7%-27% 78 66%88% 6688 66% 88% 66 88 66%-88% p 0.07. 007 0.07 07 0.07) 75 66%83% 6683 83% 83 66%-83% 64 55%72%. 5572 55% 72% 55 72 55%-72%) groups 0.654, 0654 0.654 654 0.654) 0.012. 0012 0.012 012 0.012) Singlecenter Single center study counts (CFC (COL 0. ( ≥50 (≥50% (FPS (AKSS 3 24%49 244 4 24%-49 8 76%93 769 76%-93 7%27 7%-27 66%88 668 6 66%-88 00 0.0 66%83 66%-83 55%72% 557 55%-72% 065 0.65 65 001 0.01 01 ≥5 (≥50 24%4 24%-4 76%9 76%-9 7%2 7%-2 66%8 66%-8 55%72 55%-72 06 0.6 ≥ (≥5 24%- 76%- 7%- 66%- 55%7 55%-7 (≥ 55%-

Abstract In the Brazilian and international literature, there is a defense of Bioethics studies in different contexts, pointing out that the school should be the first environment for discussions in Bioethics, being necessary to stimulate thinking about social, political and behavioral approaches, which can interfere with the lives of students and the world. Based on these assumptions, this article aimed to analyze, in the Brazilian and international literature, the themes of Bioethics, which are actually being approached in the school environment, considering the forms of use and their results. This research refers to an integrative literature review, of a qualitative nature, starting from the following guiding question: What are the themes of Bioethics worked on at school? Based on inclusion and exclusion criteria, descriptors were used, in Portuguese, Spanish and English, in the Scielo, Lilacs, Web of Science and Scopus databases. Data collection took place in August 2022. After selection, 13 articles were included, in which, through thematic analysis, they were organized into three categories: 1) Ethics in science and biotechnology; 2) Socio-environmental aspects; and 3) Ethics in science, biotechnology and socio-environmental aspects. Seven articles composed the first category and the themes found were: ethics in science (n:3), biotechnology (n:1), use of animals in research (n:2) and the role of the researcher (n:1). In the second category, there are two articles, both of which deal with the topic of environmental education. The third category, composed of four articles, was necessary because the studies present a mix of themes from the categories mentioned above. Through this integrative review, we can perceive the diversity found in studies on Bioethics themes. These themes, if used by the teacher as a pedagogical proposal, can broaden students' perspective on necessary and current topics, as all studies have demonstrated a positive impact on students with the aim of forming more critical and autonomous citizens. Furthermore, we can observe that there are few studies that investigate the use of these themes in the school environment, and further investigations are necessary.

Resumen En la literatura brasileña e internacional, hay una defensa de los estudios de Bioética en diferentes contextos, señalan que la escuela debe ser el primer ámbito para las discusiones en Bioética, siendo necesario estimular el pensamiento sobre enfoques sociales, políticos y conductuales, que pueden interfieren en la vida de los estudiantes y del mundo. A partir de estos supuestos, este artículo tuvo como objetivo analizar, en la literatura brasileña e internacional, los temas de la Bioética que actualmente están siendo abordados en el ámbito escolar, considerando las formas de uso y sus resultados. Esta investigación se refiere a una revisión integrativa de la literatura, de carácter cualitativo, a partir de la siguiente pregunta orientadora: ¿Cuáles son los temas de Bioética trabajados en la escuela? Con base en criterios de inclusión y exclusión, se utilizaron descriptores, en portugués, español e inglés, en las bases de datos Scielo, Lilacs, Web of Science y Scopus. La recolección de datos ocurrió en agosto de 2022. Después de la selección, se incluyeron 13 artículos, en los que, a través del análisis temático, se organizaron en tres categorías: 1) Ética en ciencia y biotecnología; 2) Aspectos socioambientales; y 3) Ética en ciencia, biotecnología y aspectos socioambientales. Siete artículos conformaron la primera categoría y las temáticas encontradas fueron: ética en la ciencia (n:3), biotecnología (n:1), uso de animales en investigaciones (n:2) y el papel del investigador (n:1). En la segunda categoría hay dos artículos, ambos tratan el tema de la educación ambiental. La tercera categoría, compuesta por cuatro artículos, fue necesaria porque los estudios presentan una mezcla de temas de las categorías mencionadas anteriormente. A través de esta revisión integradora, podemos percibir la diversidad encontrada en los estudios sobre temas de Bioética. Estos temas, si son utilizados por el docente como propuesta pedagógica, pueden ampliar la perspectiva de los estudiantes sobre temas necesarios y actuales, ya que todos los estudios han demostrado un impacto positivo en los estudiantes con el objetivo de formar ciudadanos más críticos y autónomos. Además, podemos observar que existen pocos estudios que investiguen el uso de estos temas en el ambiente escolar, y son necesarias más investigaciones.

Resumo Na literatura brasileira e internacional, observa-se a defesa dos estudos da Bioética em diferentes contextos, apontando que a escola deve ser o primeiro ambiente para as discussões em Bioética, sendo necessário estimular o pensar sobre abordagens sociais, políticas e comportamentais, que podem interferir na vida de estudantes e no mundo. Partindo destas premissas, este artigo teve como objetivo analisar, na literatura brasileira e internacional, os temas da Bioética que estão efetivamente sendo abordados no ambiente escolar, considerando as formas de uso e os seus resultados. Esta pesquisa se refere a uma revisão integrativa de literatura, de caráter qualitativo, partindo da seguinte pergunta balizadora: Quais são os temas da Bioética trabalhados na escola? A partir de critérios de inclusão e exclusão, foram utilizados descritores nos idiomas português, espanhol e inglês, nas bases de dados Scielo, Lilacs, Web of Science e Scopus. O levantamento dos dados ocorreu em agosto de 2022. Após a seleção, foram incluídos 13 artigos, os quais, por meio da análise temática, foram organizados em três categorias: 1) Ética na ciência e biotecnologia; 2) Aspectos socioambientais; e 3) Ética na ciência, biotecnologia e aspectos socioambientais. Sete artigos compuseram a primeira categoria e os temas encontrados foram: ética na ciência (n:3), biotecnologia (n:1), uso de animais em pesquisas (n:2) e papel do pesquisador (n:1). Na segunda categoria, estão presentes dois artigos, e ambos tratam sobre o tema da educação ambiental. A terceira categoria, composta por quatro artigos, foi necessária pois os estudos apresentam uma mescla de temas das categorias citadas anteriormente. Através dessa revisão integrativa, percebe-se a diversidade encontrada nas pesquisas com os temas da Bioética. Estes, se utilizados pelo professor como uma proposta pedagógica, podem ampliar o olhar dos estudantes sobre temas necessários e atuais, visto que todos os estudos demonstraram um impacto positivo sobre os educandos, no intuito de formar cidadãos mais críticos e autônomos. Além disso, observou-se que há poucas pesquisas que investigam a utilização desses temas no ambiente escolar, sendo necessárias novas investigações.

SUMMARY OBJECTIVE: The objective of the present study was to verify the indication of common mental disorder and changes in healthy lifestyle among individuals affected by coronavirus disease, as well as to evaluate if changes in healthy lifestyle are predictors of common mental disorder. METHODS: This descriptive, cross-sectional study employed an exploratory approach and quantitative methodology, using the Self-Reporting Questionnaire to assess the indication of common mental disorder and questions regarding healthy lifestyle during the pandemic. RESULTS: A total of 280 individuals affected by coronavirus disease, aged 18 years and above, participated in the study. The average indication for common mental disorder was 5.0±5.34. The average age was characterized by adults (41.24±14.03 years), with the majority being women (57.9%), White (51.4%), and those in stable relationships (55.7%). Worsening sleep quality (β==6.327; p<0.001) was the main predictor of common mental disorder, followed by female gender (β==2.814; p<0.001) and worsening dietary habits (β==2.227; p<0.012). CONCLUSION: These factors should be considered in the assessment of individuals affected by coronavirus disease to provide comprehensive care.

Resumen Objetivo Comprender la percepción del acceso y de la calidad de la alimentación según personas en situación de calle. Métodos Estudio descriptivo cualitativo, realizado en un Centro de Referencia de Personas de la Calle en la región centro-sur de Belo Horizonte (Minas Gerais). Se utilizó un guion semiestructurado para realizar entrevistas a 18 participantes. La recopilación de datos se realizó entre diciembre de 2020 y enero de 2021. El análisis temático del material, propuesto por Bardin, permitió la elaboración de tres categorías empíricas. Resultados El público entrevistado era masculino, de 43 años de edad promedio y tiempo promedio de situación de calle de 44,6 meses. El acceso a la alimentación fue proveniente de donaciones de alimentos, comidas en instituciones gubernamentales y adquisiciones al disponer de ingresos. Las personas relataron dificultades con relación a la cantidad y calidad de los alimentos, a la adquisición de comida los fines de semana, a los sentimientos de miedo y angustia ante el hambre, a la falta de alimentos y al estigma social, agravados por el COVID-19. Conclusión Ante el escenario de iniquidades sociales, el derecho al acceso a la alimentación no está garantizado, por lo cual es necesario implementar políticas públicas de protección social que garanticen los derechos básicos. cualitativo centrosur centro sur Minas Gerais. Gerais . Gerais) 1 participantes 202 2021 material Bardin empíricas masculino 4 446 44 6 44, meses ingresos semana hambre COVID19. COVID19 COVID 19. 19 COVID-19 sociales garantizado básicos 20 COVID1 COVID-1 2 COVID-

Abstract Objective To understand the perception of access to food and food quality for the street population. Methods This qualitative descriptive study was performed in a Reference Center for the Homeless Population in the south-central region of Belo Horizonte (MG). A semi-structured script was used to conduct interviews with 18 participants. Data collection occurred between December 2020 and January 2021. The thematic analysis of the material, as proposed by Bardin, made it possible to elaborate three empirical categories. Results The public interviewed was male, with a mean age of 43 years, and a mean time on the streets of 44.6 months. Access to food came from donations, meals at government institutions, and acquisition when income was available. Difficulties were reported regarding the quantity and quality of food, acquisition of meals on weekends, feelings of fear and anguish in the face of hunger, lack of food, and social stigma, which were aggravated by COVID-19. Conclusion As in this scenario of social inequalities the access to food is not guaranteed, implementing public policies of social protection is necessary to guarantee basic rights. population southcentral south central MG. MG . (MG) semistructured semi structured 1 participants 202 2021 material Bardin categories male 4 years 446 44 6 44. months donations institutions available weekends hunger stigma COVID19. COVID19 COVID 19. 19 COVID-19 guaranteed rights (MG 20 COVID1 COVID-1 2 COVID-

Resumo Objetivo Compreender a percepção do acesso e da qualidade da alimentação para a população em situação de rua. Métodos Estudo descritivo qualitativo, realizado em um Centro de Referência da População de Rua na região centro-sul de Belo Horizonte (MG). Utilizou-se roteiro semiestruturado para a realização das entrevistas de 18 participantes. A coleta de dados ocorreu entre dezembro de 2020 e janeiro de 2021. A análise temática do material, proposta por Bardin, possibilitou a elaboração de três categorias empíricas. Resultados O público entrevistado era masculino, com idade média de 43 anos e tempo médio de situação de rua de 44,6 meses. O acesso à alimentação foi proveniente das doações de alimentos, refeições em instituições governamentais e aquisições ao dispor de renda. Foram relatadas dificuldades quanto à quantidade e qualidade dos alimentos, à aquisição das refeições nos fins de semana, aos sentimentos de medo e angústia perante a fome, à falta do alimento e pelo estigma social, agravados pela COVID-19. Conclusão Diante do cenário de iniquidades sociais, o direito ao acesso à alimentação não é garantido, sendo necessária a implementação de políticas públicas de proteção social que garantam os direitos básicos. qualitativo centrosul centro sul MG. MG . (MG) Utilizouse Utilizou se 1 participantes 202 2021 material Bardin empíricas masculino 4 446 44 6 44, meses alimentos renda semana fome COVID19. COVID19 COVID 19. 19 COVID-19 sociais garantido básicos (MG 20 COVID1 COVID-1 2 COVID-

ABSTRACT Purpose To describe the characteristics of the initial public health training for speech-language-hearing therapists in Northeastern Brazil. Methods The research was based on the curricular framework of public higher education institutions in the Northeast. The analysis approached each institution’s general speech-language-hearing program data (state where it is located, total course load, and most recent curricular framework reformulation) and specific data on public health courses (their individual course load, the term when it is offered, syllabus content, whether it was theoretical, practical, both, or internship, and whether it was required or elective). Results The data show that eight public higher education institutions in the Northeast offer speech-language-hearing programs, whose pedagogical frameworks date from 2009 to 2021. The total course load of those related to public health ranges from 7.5% to 20.5% of the total program among those analyzed. Most courses were elective, exclusively theoretical, and were offered in the first half of the program. Conclusion The initial public health training for speech-language-hearing therapists in public higher education institutions in the Northeast still seems to be based on traditional practices. These create a distance between students, public health, and practices that meet the principles of Health Unic System (in Portuguese - Sistema Único de Saúde) and the population’s real needs, especially in primary healthcare speechlanguagehearing speech language hearing Brazil institution s state located reformulation their content theoretical practical both internship elective. elective . elective) programs 200 2021 75 7 5 7.5 205 20 20.5 analyzed students Saúde populations population needs 202 7. 2 20.

RESUMO Objetivo Descrever as características da formação inicial em saúde coletiva de fonoaudiólogos do Nordeste do Brasil. Método A pesquisa foi realizada com base nas matrizes curriculares de Instituições de Ensino Superior (IES) públicas do Nordeste a partir das quais foram analisados dados gerais dos cursos de Fonoaudiologia de cada Instituição ー estado em que está localizado, carga horária total e última reformulação de matriz curricular; e dados que diziam respeito especificamente às disciplinas relacionadas à Saúde Coletiva ー carga horária de cada disciplina, semestre de oferta, conteúdo da ementa, caráter teórico, prático, teórico-prático ou estágio, se obrigatória ou optativa. Resultados Os dados revelam que existem oito IES públicas do nordeste que oferecem o curso de Fonoaudiologia, sendo que os Projetos Pedagógicos de Cursos datam de 2009 a 2021. A Carga Horária (CH) total das disciplinas vinculadas à área de Saúde Coletiva varia de 7,5% a 20,5% da CH total dos cursos analisados. A maioria destas disciplinas é eletiva, tem caráter teórico e é ofertada na primeira metade da formação. Conclusão A formação inicial em saúde coletiva de fonoaudiólogos de IES públicas do nordeste parece ainda estar embasada em práticas tradicionais, que acabam distanciando os discentes do campo da saúde coletiva e de práticas que atendam os princípios do Sistema Único de Saúde, e as reais necessidades da população, especialmente na Atenção Primária à Saúde. Brasil (IES localizado curricular disciplina oferta ementa prático teóricoprático estágio optativa 200 2021 (CH 75 7 5 7,5 205 20 20,5 eletiva tradicionais população 202 7, 2 20,

Abstract Natural products have been studied as potential anthelmintic drugs. This study aimed to evaluate the effects of the polypeptides/proteins exuded from Mimosa caesalpiniifolia mature seeds on the model nematode Caenorhabditis elegans. After seed immersion for 24 h at 25 ºC in sodium phosphate buffer, pH 7.0, containing 0.15 M NaCl and 1.0 M MgSO4, the constituent polypeptides/proteins were fractionated using ammonium sulfate precipitation followed by ultrafiltration and their effects on C. elegans motility were assessed. Moreover, we evaluated by Atomic Force Microscopy (AFM) whether exposition of the nematode to the polypeptide fraction McSEX10-2 could cause any alteration on the animal’s external surface (cuticle). The whole seed exudates (SEX) from the M. caesalpiniifolia mature seeds (named McSEX) and its polypeptide/protein derived fractions, termed McSEX90%/80°C, McSEX30-10, and McSEX10-2, inhibited the C. elegans motility with an IC50 of 15.18, 12.59, 9.74 and 1.34 μg mL-1.The McSEX10-2 fraction, which encompassed the polypeptides with the molecular mass varying from 10 kDa to 2 kDa, was the most effective. In addition, McSEX10-2 altered the ultrastructure and the mechanical properties of the C. elegans cuticle. McSEX10-2, in particular, can be used as a model to bioinspire structure-based design of new peptides that could control, alone or in combination with other drugs, economically important parasitic nematodes. drugs polypeptidesproteins proteins buffer 70 7 0 7.0 015 15 0.1 1 1. MgSO4 MgSO C assessed Moreover AFM (AFM McSEX102 McSEX McSEX10 McSEX10- animals animal s cuticle . (cuticle) SEX (SEX named polypeptideprotein protein fractions McSEX9080C McSEXC McSEX90 80 McSEX90%/80°C McSEX3010, McSEX3010 McSEX30 10, McSEX30-10 McSEX102, 2, IC IC5 1518 18 15.18 1259 12 59 12.59 974 9 74 9.7 134 34 1.3 mL1.The mL1The mLThe mL 1.The effective addition particular structurebased structure based control nematodes 7. 01 0. McSEX1 (cuticle McSEX9 8 McSEX301 McSEX3 McSEX30-1 151 15.1 125 5 12.5 97 9. 13 3 mL1 1The McSEX30- 15. 12.

Abstract Information regarding organism changes due to the variation of abiotic factors such as salinity are essential in both ecotoxicological and environmental monitoring studies. For this reason, the Brazilian silverside (Atherinella brasiliensis) embryos were exposed to different salinity conditions (10–35) for 12 days and changes at molecular and individual levels were assessed. The embryos did not present alterations in the morphology or hatching during their development. However, they showed an increase in heart rate after seven days, close to the hatching period. The expression of the cystic fibrosis transmembrane regulator (cftr), one of the channels responsible for osmoregulation, was cloned and it was not significantly affected by the exposure. The obtained results indicated that the Brazilian silverside embryos acclimate in a broad range of salinities and can be used to study fish response at environmentally relevant conditions. In addition, this species can be used to assess the risk related to chemical compounds which toxicity may vary in different salinity conditions. studies reason Atherinella brasiliensis 10–35 1035 10 35 (10–35 1 assessed development However period cftr, cftr , (cftr) osmoregulation exposure addition 10–3 103 3 (10–3 (cftr 10– (10– (10 (1 (

Resumo As informações relativas a mudanças nos organismos causadas por variações abióticas, como a salinidade, são essenciais para estudos de ecotoxicologia e monitoramento ambiental. Por esta razão, embriões da espécie eurialina do peixe-rei, Atherinella brasiliensis, foram expostos a diferentes condições de salinidade (10–35) por 12 dias para analisar possíveis mudanças morfológicas e moleculares. Os embriões não apresentaram alterações fenotípicas ou de eclosão durante o seu desenvolvimento. No entanto, eles demonstraram aumento no ritmo cardíaco após sete dias, próximo ao período de eclosão. A expressão do regulador transmembranar da fibrose cística (cftr), um dos canais responsáveis pela osmorregulação, foi clonado e analisado, mas não apresentou variação significativa. Os resultados obtidos indicaram que os embriões de peixe-rei podem se aclimatar a uma ampla faixa de salinidades e podem ser usados para estudar a resposta dos peixes a condições ambientalmente relevantes. Adicionalmente, esta espécie pode ser usada para a avaliação de risco relacionada a compostos químicos, cuja toxicidade pode variar em diferentes condições de salinidade. abióticas ambiental razão peixerei, peixerei peixe rei, rei brasiliensis 10–35 1035 10 35 (10–35 1 moleculares desenvolvimento entanto cftr, cftr , (cftr) osmorregulação analisado significativa relevantes Adicionalmente químicos 10–3 103 3 (10–3 (cftr 10– (10– (10 (1 (

RESUMEN Objetivo: Comprender el papel del enfermero de Atención Primaria de Salud en el tratamiento de la Disfunción del Tracto Urinario Inferior. Método: Investigación transversal multimetodológica, compuesta por etapas cuantitativas y cualitativas, de forma independiente y secuencial. Datos recopilados de forma remota, a través de un cuestionario y un grupo focal, analizados mediante estadística descriptiva y análisis temático de Braun y Clarke, respectivamente. El proyecto fue aprobado bajo Opinión 22691119.0.0000.0030. Resultados: Participaron del estudio 145 enfermeros en la etapa cuantitativa y 20 en la cualitativa, actuando en la Atención Primaria de Salud en Brasil. Del 93,1% de los enfermeros que afirmaron haber atendido ya a personas con Disfunción del Tracto Urinario, sólo el 54,4% brindó orientación, principalmente para el entrenamiento de los músculos del suelo pélvico. Conclusión: Incluso con apoyo legal y acceso a la demanda, los enfermeros no tienen el conocimiento para ofrecer tratamiento conservador para la Disfunción del Tracto Urinario Inferior. Pese a ello, estaban motivados para hacerlo siempre que recibieran una formación específica. Objetivo Inferior Método multimetodológica cualitativas secuencial remota focal Clarke respectivamente 22691119000000030 22691119 0 0000 0030 22691119.0.0000.0030 Resultados 14 2 cualitativa Brasil 931 93 1 93,1 544 54 4 54,4 orientación pélvico Conclusión demanda ello específica 2269111900000003 2269111 000 003 22691119.0.0000.003 9 93, 5 54, 226911190000000 226911 00 22691119.0.0000.00 22691119000000 22691 22691119.0.0000.0 2269111900000 2269 22691119.0.0000. 226911190000 226 22691119.0.0000 22691119000 22 22691119.0.000 2269111900 22691119.0.00 226911190 22691119.0.0 22691119.0. 22691119.0 22691119.

ABSTRACT Objective: To understand Primary Health Care nurses’ role in treating Lower Urinary Tract Dysfunction. Method: Cross-sectional multi-methodological research, composed of quantitative and qualitative steps, independently and sequentially. Data collected remotely, through a questionnaire and focus group, analyzed using descriptive statistics and thematic analysis by Braun and Clarke, respectively. The project was approved under Opinion 22691119.0.0000.0030. Results: A total of 145 nurses participated in the study in the quantitative step and 20 in the qualitative step, working in Primary Health Care in Brazil. Of the 93.1% nurses who reported having already cared for people with Urinary Tract Dysfunction, only 54.4% provided guidance, mainly for training the pelvic floor muscles. Conclusion: Even though they have legal support and access to demand, nurses do not have the knowledge to offer conservative treatment for Lower Urinary Tract Dysfunction. Despite this, they were motivated to do so as long as they received specific training. Objective Dysfunction Method Crosssectional Cross sectional multimethodological multi methodological research steps sequentially remotely group Clarke respectively 22691119000000030 22691119 0 0000 0030 22691119.0.0000.0030 Results 14 2 Brazil 931 93 1 93.1 544 54 4 54.4 guidance muscles Conclusion demand this 2269111900000003 2269111 000 003 22691119.0.0000.003 9 93. 5 54. 226911190000000 226911 00 22691119.0.0000.00 22691119000000 22691 22691119.0.0000.0 2269111900000 2269 22691119.0.0000. 226911190000 226 22691119.0.0000 22691119000 22 22691119.0.000 2269111900 22691119.0.00 226911190 22691119.0.0 22691119.0. 22691119.0 22691119.

RESUMO Objetivo: Compreender a atuação dos enfermeiros da Atenção Primaria à Saúde no tratamento da Disfunção do Trato Urinário Inferior. Método: Pesquisa transversal multi-metodológica, composta por etapas quantitativa e qualitativa, de forma independente e sequencial. Dados coletados de forma remota, por meio de questionário e grupo focal, analisados por estatística descritiva e análise temática de Braun e Clarke, respectivamente. O projeto foi aprovado sob Parecer no. 22691119.0.0000.0030. Resultados: Participaram do estudo 145 enfermeiros na etapa quantitativa e 20 na qualitativa, atuantes na Atenção Primária à Saúde do Brasil. Dos 93,1% enfermeiros que referiram já terem atendido pessoas com Disfunção do Trato Urinário, apenas 54,4% prestaram orientações, sendo principalmente para treinamento da musculatura do assoalho pélvico. Conclusão: Mesmo possuindo respaldo legal e acesso à demanda, os enfermeiros não têm conhecimento para oferecer tratamento conservador para Disfunção do Trato Urinário Inferior. Apesar disso, mostraram-se motivados para tal atuação desde que recebam capacitação específica. Objetivo Inferior Método multimetodológica, multimetodológica multi metodológica, metodológica multi-metodológica qualitativa sequencial remota focal Clarke respectivamente 22691119000000030 22691119 0 0000 0030 22691119.0.0000.0030 Resultados 14 2 Brasil 931 93 1 93,1 544 54 4 54,4 orientações pélvico Conclusão demanda disso mostraramse mostraram se específica 2269111900000003 2269111 000 003 22691119.0.0000.003 9 93, 5 54, 226911190000000 226911 00 22691119.0.0000.00 22691119000000 22691 22691119.0.0000.0 2269111900000 2269 22691119.0.0000. 226911190000 226 22691119.0.0000 22691119000 22 22691119.0.000 2269111900 22691119.0.00 226911190 22691119.0.0 22691119.0. 22691119.0 22691119.

Resumen: El trabajo tiene el objetivo de analizar los principales patrones de organización de las redes municipales de servicios de atención primaria de salud (APS) y evaluarlos conforme los indicadores de interfaz entre la dirección y gestión local. Se trata de una investigación evaluativa que analizó 461 municipios de São Paulo, Brasil, que participaron de la Encuesta de Evaluación de la Calidad de los Servicios de Atención Primaria (QualiAB) en 2017/2018, clasificados según la composición de los arreglos organizativos de 2.472 servicios de APS. Para evaluar los patrones identificados, se seleccionaron ocho indicadores de dirección y gestión local. Los resultados indican dos grupos de municipios: homogéneos, con servicios de un mismo arreglo (43,6%) e heterogéneos, con arreglos diferentes (56,4%). Los grupos se subdividieron en siete patrones que iban desde homogéneo-tradicional, homogéneo-Estrategia de Salud de la Familia, homogéneo-mixto y diferentes combinaciones en el grupo heterogéneo. Todos los indicadores señalaron diferencias significativas entre los grupos (p < 0,001), con destaque para el grupo homogéneo-tradicional, con patrón organizativo alejado del modelo deseado para una APS completa y resolutiva, mientras aquellos con unidades de salud de la familia (USF), y con unidades básicas con agentes comunitarios de salud y/o equipos de salud de la familia (UBS/USF) demostraron un patrón más cercano a este modelo -con acciones de planificación y evaluación comprometidas con la realidad local y con la calificación del trabajo. Se discute la importancia de las políticas implementadas por la gestión federal y la gestión estatal y su poder de inducción para definir el modelo de atención a la salud en la APS de los municipios. Resumen (APS 46 Paulo Brasil QualiAB (QualiAB 20172018 2017 2018 2017/2018 2472 2 472 2.47 identificados homogéneos 43,6% 436 43 6 (43,6% heterogéneos 56,4%. 564 56,4% . 56 4 (56,4%) homogéneotradicional, homogéneotradicional homogéneo tradicional, tradicional homogéneo-tradicional homogéneoEstrategia Estrategia Familia homogéneomixto mixto heterogéneo p 0,001, 0001 0,001 , 0 001 0,001) resolutiva USF, USF (USF) yo o UBS/USF UBSUSF UBS (UBS/USF 2017201 201 2017/201 247 47 2.4 43,6 (43,6 56,4 5 (56,4% 000 0,00 00 (USF 201720 20 2017/20 24 2. 43, (43, 56, (56,4 0,0 20172 2017/2 (43 (56, 0, 2017/ (4 (56 ( (5

Abstract: This study analyzes the main organization patterns used by primary health care (PHC) services in municipal networks and evaluates them according to indicators of local management-administration interface. Evaluative research analyzed 461 municipalities in São Paulo, Brazil, that participated in the Primary Care Services Quality Assessment Survey (QualiAB) in 2017/2018, classified according to the organizational arrangements composition of 2,472 PHC services. Eight indicators of local management and administration were selected to evaluate the identified patterns. Results indicate two groups of municipalities: homogeneous, with services presenting the same arrangement (43.6%); and heterogeneous, with different arrangements (56.4%). These were subdivided into seven patterns that ranged from homogeneous-traditional, homogeneous-Family Health Strategy, homogeneous-mixed, and different combinations in the heterogeneous group. All indicators showed significant differences between groups (p < 0.001), especially the homogeneous-traditional group, which presented an organizational pattern far from the desired model of a comprehensive and problem-solving PHC. Those integrated with family health units (FHU) and basic health units with community health workers and/or family health teams (BHU/FHU) showed a pattern closer to a comprehensive model - with planning and evaluation actions committed to the local reality and qualification of care. Implementation of federal and state policies are essential for defining the PHC health care model adopted by municipalities. Abstract (PHC managementadministration interface 46 Paulo Brazil QualiAB (QualiAB 20172018 2017 2018 2017/2018 2472 2 472 2,47 homogeneous 43.6% 436 43 6 (43.6%) 56.4%. 564 56.4% . 56 4 (56.4%) homogeneoustraditional, homogeneoustraditional traditional, traditional homogeneousFamily Family Strategy homogeneousmixed, homogeneousmixed mixed, mixed homogeneous-mixed group p 0.001, 0001 0.001 , 0 001 0.001) problemsolving problem solving FHU (FHU andor or BHU/FHU BHUFHU BHU (BHU/FHU 2017201 201 2017/201 247 47 2,4 43.6 (43.6% 56.4 5 (56.4% 000 0.00 00 201720 20 2017/20 24 2, 43. (43.6 56. (56.4 0.0 20172 2017/2 (43. (56. 0. 2017/ (43 (56 (4 (5 (

Resumo: Este trabalho tem como objetivo analisar os principais padrões de organização das redes municipais de serviços de atenção primária à saúde (APS) e avaliá-los segundo os indicadores de interface entre gestão e gerenciamento local. Trata-se de pesquisa avaliativa que analisou 461 municípios de São Paulo, Brasil, que participaram do Inquérito de Avaliação da Qualidade de Serviços de Atenção Básica (QualiAB) em 2017/2018, classificados segundo a composição dos arranjos organizacionais de 2.472 serviços de APS. Para avaliar os padrões identificados, foram selecionados oito indicadores de gestão e gerenciamento local. Os resultados apontam dois grupos de municípios: homogêneos, com serviços de um mesmo arranjo (43,6%); e heterogêneos, com diferentes arranjos (56,4%). Os grupos foram subdivididos em sete padrões que variaram entre homogêneo-tradicional, homogêneo-Estratégia Saúde da Família, homogêneo-misto e diferentes combinações no grupo heterogêneo. Todos os indicadores apontaram diferenças significativas entre os grupos (p < 0,001), com destaque para o grupo homogêneo-tradicional, com padrão organizacional distante do modelo desejado para uma APS abrangente e resolutiva, enquanto aqueles com unidades de saúde da família (USF), e com unidades básicas com agentes comunitários de saúde e/ou equipes de saúde da família (UBS/USF) demonstraram um padrão mais aproximado desse modelo - com ações de planejamento e avaliação comprometidos com a realidade local e com a qualificação do trabalho. Discute-se a importância das políticas implementadas pela gestão federal e estadual e seu poder de indução na definição do modelo de atenção à saúde na APS dos municípios. Resumo (APS avaliálos avaliá los Tratase Trata se 46 Paulo Brasil QualiAB (QualiAB 20172018 2017 2018 2017/2018 2472 2 472 2.47 identificados homogêneos 43,6% 436 43 6 (43,6%) heterogêneos 56,4%. 564 56,4% . 56 4 (56,4%) homogêneotradicional, homogêneotradicional homogêneo tradicional, tradicional homogêneo-tradicional homogêneoEstratégia Estratégia Família homogêneomisto misto heterogêneo p 0,001, 0001 0,001 , 0 001 0,001) resolutiva USF, USF (USF) eou ou UBS/USF UBSUSF UBS (UBS/USF Discutese Discute 2017201 201 2017/201 247 47 2.4 43,6 (43,6% 56,4 5 (56,4% 000 0,00 00 (USF 201720 20 2017/20 24 2. 43, (43,6 56, (56,4 0,0 20172 2017/2 (43, (56, 0, 2017/ (43 (56 (4 (5 (

Abstract Objectives Medical training negatively impacts the quality of life of students. Assessing the well-being of medical students could guide academic policies and future research for improving the mental and physical health status of the population at risk. This study aimed to identify the influence of medical training on the quality of life of Brazilian medical students. Methods A systematic review and meta-analysis was conducted according to the Cochrane criteria and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol (PRISMA). The search was performed by two independent investigators using a predefined protocol registered on the PROSPERO database (CRD42021237926). Data were extracted from PubMed, Embase, and Biblioteca Virtual de Saúde (BVS). For quantitative synthesis, a meta-analysis was conducted to assess the mean difference in the quality of life between medical students at different stages in the academic cycle, stratified by sex. All data were analyzed using the random-effects model, with a confidence interval of 95% (95%CI). Results After evaluating the eligibility criteria, five studies were included in the meta-analysis. The data revealed that students in the pre-clinical cycle of the course exhibited higher quality of life scores in the physical (3.05 [1.48-4.62], p < 0.0001) and psychological (3.05 [0.80-5.30], p < 0.0001) domains than students in the clerkship cycle. No statistically significant differences were observed in the environmental (0.78 [-2.92-4.49], p = 0.68) or social domains (1.41 [-0.52-3.34], p = 0.15). Conclusion Our analysis revealed that the medical course is associated with decreased quality of life of medical students in the physical and psychological domains. This finding was observed in both men and women. However, these findings should be interpreted with caution given the study limitations. Registration number PROSPERO, CRD42021237926. wellbeing well being risk metaanalysis meta MetaAnalyses Meta Analyses PRISMA. PRISMA . (PRISMA) CRD42021237926 CRD (CRD42021237926) PubMed Embase BVS. BVS (BVS) synthesis sex randomeffects random effects model 95 95%CI. 95CI CI 95%CI (95%CI) metaanalysis. analysis. preclinical pre clinical 3.05 305 3 05 (3.0 1.484.62, 148462 1.48 4.62 , 1 48 4 62 [1.48-4.62] 0.0001 00001 0 0001 0.805.30, 080530 0.80 5.30 80 5 30 [0.80-5.30] 0.78 078 78 (0.7 2.924.49, 292449 2.92 4.49 2 92 49 [-2.92-4.49] 0.68 068 68 1.41 141 41 (1.4 0.523.34, 052334 0.52 3.34 52 34 [-0.52-3.34] 0.15. 015 0.15 15 0.15) women However limitations (PRISMA CRD4202123792 (CRD42021237926 (BVS 9 (95%CI 3.0 (3. 484 1.484.62 14846 148 1.4 462 4.6 6 [1.48-4.62 0.000 0000 000 805 0.805.30 08053 080 0.8 530 5.3 8 [0.80-5.30 0.7 07 7 (0. 924 2.924.49 29244 292 2.9 449 4.4 [-2.92-4.49 0.6 06 14 (1. 523 0.523.34 05233 052 0.5 334 3.3 [-0.52-3.34 01 0.1 CRD420212379 (CRD4202123792 3. (3 1.484.6 1484 1. 46 4. [1.48-4.6 0.00 00 0.805.3 0805 08 0. 53 5. [0.80-5.3 (0 2.924.4 2924 29 2. 44 [-2.92-4.4 (1 0.523.3 0523 33 [-0.52-3.3 CRD42021237 (CRD420212379 ( 1.484. [1.48-4. 0.0 0.805. [0.80-5. 2.924. [-2.92-4. 0.523. [-0.52-3. CRD4202123 (CRD42021237 1.484 [1.48-4 0.805 [0.80-5 2.924 [-2.92-4 0.523 [-0.52-3 CRD420212 (CRD4202123 [1.48- [0.80- [-2.92- [-0.52- CRD42021 (CRD420212 [1.48 [0.80 [-2.92 [-0.52 CRD4202 (CRD42021 [1.4 [0.8 [-2.9 [-0.5 CRD420 (CRD4202 [1. [0. [-2. [-0. CRD42 (CRD420 [1 [0 [-2 [-0 CRD4 (CRD42 [ [- (CRD4 (CRD

Abstract This study aimed to identify and characterize the antimicrobial susceptibility profile of bacteria found in primary endodontic infections in the teeth of patients treated at the Dental Clinic of the University of Ribeirão Preto, São Paulo, Brazil. From September to December 2019, samples were obtained from 21 patients with primary endodontic infections. The collections were carried out in triplicate using paper cones placed close to the total length of the root canal. Bacterial isolation was performed in Brain Heart Infusion agar, Blood agar, and other selective culture media cultured at 37°C for up to 48 h under aerobiosis and microaerophilic conditions. The bacterial species were identified using the Vitek 2 automated system. The disk diffusion method on agar Müeller–Hinton was used to assess antimicrobial susceptibility with the recommended antimicrobials for each identified bacterial species. A total of 49 antibiotics were evaluated. Fifteen of the 21 samples collected showed bacterial growth, and 17 bacterial isolates were found. There were 10 different bacterial species identified: Enterococcus faecalis (four isolates), Streptococcus mitis/oralis (three isolates), Streptococcus anginosus (three isolates) being the most common, followed by Staphylococcus epidermidis, Enterococcus faecium, Streptococcus constellatus, Streptococcus alactolyticus, Enterobacter cloacae, Klebsiella variicola, and Providencia rettgeri (one isolate of each species). The analysis demonstrated significant susceptibility to most of the tested antibiotics. However, some Enterococcus isolates resisted the antibiotic’s erythromycin, ciprofloxacin, and tetracycline. A Staphylococcus epidermidis isolate was characterized as multidrug-resistant. Five Streptococcus isolates were non-susceptible to all antibiotics tested. Preto Paulo Brazil 2019 canal 37C C 37 4 conditions system MüellerHinton Müeller Hinton evaluated growth 1 four isolates, , mitisoralis mitis oralis three common faecium constellatus alactolyticus cloacae variicola one . species) However antibiotic s erythromycin ciprofloxacin tetracycline multidrugresistant. multidrugresistant multidrug resistant. resistant multidrug-resistant nonsusceptible non susceptible 201 3 20

ABSTRACT Physical properties of the Technosols formed by the tailings deposition may constitute a physical barrier that limits water movement and plant development due to the properties received from those sediments. This study aimed to evaluate the physical quality of the Technosols formed by the deposition of sediments displaced by the Fundão Dam failure, Mariana, Minas Gerais State, Brazil, based on the evaluation of physical properties and Load Bearing Capacity Models (LBCM). For that, three areas under different vegetation types were selected: eucalyptus (Euc), forest with human-assisted revegetation (RF), and forest with native vegetation (NF). Three sampling subareas were demarcated in each area: non-impacted areas (Ni), and Technosols formed in directly impacted areas (Di), and partially impacted areas (Pi). Undisturbed samples were collected in two layers and subjected to the uniaxial compression test after equilibration at five matric potentials. Soil compression curves and LBCM were determined. Soil bulk density (BD), total porosity (TP), organic matter (OM), granulometry, and particle density (PD) were also determined. Clay content was less significant, and the silt and very fine sand content was significantly higher in the Technosols, generating an increase in BD and reduction in TP. Technosols generally exhibited greater load-bearing capacity due to higher pre-consolidation pressure values attained by these soils due to the lower clay and OM contents. High resistance of these soils is one limitation for revegetation of the areas evaluated, being necessary management practices to improve physical properties of the Technosols. failure Mariana State Brazil LBCM. . (LBCM) selected Euc, Euc , (Euc) humanassisted human assisted RF, RF (RF) NF. NF (NF) area nonimpacted non Ni, Ni (Ni) Di, Di (Di) Pi. Pi (Pi) potentials determined BD, (BD) TP, TP (TP) OM, (OM) granulometry PD (PD significant loadbearing load bearing preconsolidation pre consolidation contents evaluated (LBCM (Euc (RF (NF (Ni (Di (Pi (BD (TP (OM

ABSTRACT Purpose This study aimed to investigate three-dimensional facial soft tissue dimensions, maximum bite force (MBF), and occlusal contact area in patients with DFD. In addition, we analyzed the relationship between MBF and the three-dimensional facial measurements. Methods Thirty-two patients with skeletal Class III DFD and 20 patients with Class II DFD underwent a soft tissue evaluation using surface laser scanning, as well as MBF and occlusal contact area assessments. The DFD groups were compared with each other and with 25 healthy subjects. Results Significant morphological differences were found in the transversal, vertical, and anteroposterior dimensions between Class II DFD and Class III DFD. Both DFD groups presented an increased linear distance of chin height, which was strongly related with decreased MBF magnitude. The DFD groups exhibited lower MBF and occlusal contact area, with no significant differences between Class II and Class III DFD. Conclusion The presence of DFD affected 3D measurements of facial soft tissue, causing variations beyond normal limits, lower MBF, and occlusal contact area in both Class II and Class III DFD patients. The vertical dimension might have influenced the lower MBF magnitude in the studied skeletal deformities. threedimensional three dimensional , (MBF) addition Thirtytwo Thirty two 2 scanning assessments subjects transversal height D limits deformities (MBF