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Considerando los desafíos para la rehabilitación psicosocial, el objetivo fue comprender la perspectiva de usuarios y trabajadores en el tratamiento psicofarmacéutico. Se trata de un estudio cualitativo que entrevistó a seis profesionales y a diez usuarios del Centro de Atención Psicosocial de un municipio de la región norte de Minas Gerais. Las transcripciones fueron tratadas en Ciclos de Codificación y examinadas por el Análisis del Discurso. Se definieron tres categorías relativas a la dimensión micropolítica del cuidado: el diagrama de flujo institucional, los espacios intercesores y la producción subjetiva de los agentes. Se revelaron disonancias entre enunciados alusivos a la política de la atención psicosocial, con la concurrencia de concepciones y tecnologías de cuidado emancipatorias y restrictivas. Se constató la importancia del análisis micropolítico del cuidado en el tratamiento psicofarmacéutico, favoreciendo los procesos de contractualidad, protagonismo y autonomía del usuario.

Considering the challenges to psychosocial rehabilitation, this study was aimed at understanding the perspective of users and workers regarding psychopharmacological treatment. This is a qualitative study, which interviewed six providers and ten users of the Psychosocial Care Center of a municipality in the north of Minas Gerais. The transcripts were treated in Coding Cycles and examined by Discourse Analysis. Three categories related to the micropolitical dimension of care were defined: the institutional flowchart; the intercessory spaces; and the subjective production of the agents. Dissonances were revealed between statements alluding to the psychosocial care policy, with the competition of emancipatory and restrictive conceptions and technologies of care. The importance of the micropolitical analysis of care in psychopharmacological treatment was verified, favoring the processes of contractuality, protagonism, and user autonomy.

Considerando os desafios à reabilitação psicossocial, objetivou-se compreender a perspectiva de usuários e trabalhadores no tratamento psicofarmacológico. Trata-se de um estudo qualitativo que entrevistou seis profissionais e dez usuários do Centro de Atenção Psicossocial de um município da região norte de Minas Gerais. As transcrições foram tratadas em Ciclos de Codificação e examinadas pela Análise de Discurso. Definiram-se três categorias relativas à dimensão micropolítica do cuidado: o fluxograma institucional, os espaços intercessores e a produção subjetiva dos agentes. Revelaram-se dissonâncias entre enunciados alusivos à política da atenção psicossocial, com a concorrência de concepções e tecnologias de cuidado emancipatórias e restritivas. Constatou-se a importância da análise micropolítica do cuidado no tratamento psicofarmacológico, favorecendo os processos de contratualidade, protagonismo e autonomia do usuário.

https://doi.org/10.1590/interface.230212

Use of insect repellent as personal protection among women of childbearing age in an arbovirus endemic area in Northeastern Brazil
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Dias, Livia Karla Sales

; Sanhueza-Sanzana, Carlos

; Pinheiro Júnior, Francisco Marto Leal

; Martins, Adriano Ferreira

; Correia, Francisco Gustavo Silveira

; de Aguiar, Italo Wesley Oliveira

; Ferreira, Nayane Cavalcante

; Stolow, Jeni

; Rutherford, George

; Teixeira, Maria Gloria

; Pires Neto, Roberto da Justa

; de Almeida, Rosa Livia Freitas

; Coelho, Ivo Castelo Branco

; Frota, Cristiane Cunha

; Kendall, Carl

; Kerr, Ligia Regina Franco Sansigolo

Revista Brasileira de Epidemiologia

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2024, Volume 27 elocation e240025

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To analyze the factors associated with the individual use of insect repellent by women of childbearing age living in area endemic for arboviruses in Fortaleza, Brazil. Methods: This is a cohort study carried out between 2018 and 2019 with women aged between 15 and 39 years in Fortaleza, state of Ceará, Brazil. A total of 1,173 women users of one of the four selected primary health care units participated in the study. The outcome was divided into: continued use, discontinued use, and nonuse of insect repellent. Crude and adjusted multinominal logistic regression analysis was carried out guided by a hierarchical model, with presentation of the respective odds ratio (OR) and 95% confidence intervals (95%CI). The independent variables include: socioeconomic and demographic data, environmental and sanitary characteristics, knowledge of the insect repellent, and behavioral and pregnancy-related aspects. Results: Only 28% of the participants reported using insect repellent during the two waves of the cohort. Women with higher education (OR=2.55; 95%CI 1.44–4.51); who are employed (OR=1.51; 95%CI 1.12–2.03); who received guidance from healthcare professionals (OR=1.74; 95%CI 1.28–2.36) and the media (OR=1.43; 95%CI 1.01–2.02); who intensified precautions against mosquitoes during the epidemic (OR=3.64; 95%CI 2.29–5.78); and who were pregnant between 2016 and 2019 (OR=2.80; 95%CI 1.83–4.30) had increased odds for continued use of insect repellent. Conclusion: The use of insect repellent among women of childbearing age was associated with a higher level of education, employment, guidance on insect repellent provided by healthcare professionals and the media, behavioral changes to protect against mosquitoes during the Zika virus epidemic, and pregnancy when occurring as of the beginning of the epidemic period.

RESUMO Objetivo: Analisar os fatores associados ao uso de repelente individual por mulheres em idade fértil residentes em área endêmicas para arboviroses em Fortaleza, Brasil. Métodos: Coorte realizada entre 2018 e 2019, com mulheres entre 15 e 39 anos, moradoras em Fortaleza, Ceará, Brasil. Participaram 1.173 mulheres, usuárias de quatro unidades primárias de saúde do município. O desfecho foi categorizado em: uso continuado, uso descontinuado e não uso de repelente. Realizada análise de regressão logística multinominal norteada por modelo hierárquico, com apresentação dos respectivos odds ratio (OR) e intervalos de confiança de 95% (IC95%). As variáveis independentes incluem: dados socioeconômicos e demográficos, características ambientais e sanitárias, conhecimento sobre o repelente e aspectos comportamentais e relacionados à gravidez. Resultados: Somente 28% das participantes referiram o uso de repelente durante as duas ondas da coorte. Mulheres com escolaridade superior (OR=2,55; IC95% 1,44–4,51); com emprego (OR=1,51; IC95% 1,12–2,03); que receberam orientações por profissionais da saúde (OR=1,74; IC95% 1,28–2,36) e pela mídia (OR=1,43; IC95% 1,01–2,02); que intensificaram os cuidados contra o mosquito na epidemia (OR=3,64; IC95% 2,29–5,78); estavam grávidas entre 2016 e 2019 (OR=2,80; IC95% 1,83–4,30) tiveram as chances aumentadas para uso continuado de repelente. Conclusões: O uso de repelente entre mulheres em idade fértil mostrou-se associado a um maior nível de escolaridade, ao emprego, às orientações sobre repelente fornecidas por profissionais de saúde e pela mídia, às mudanças comportamentais de cuidado contra o mosquito durante a epidemia da Zika e à gravidez quando ocorrida a partir do início do período epidêmico.

https://doi.org/10.1590/1980-549720240025

Use of insect repellent as personal protection among women of childbearing age in an arbovirus endemic area in Northeastern Brazil
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Dias, Livia Karla Sales

; Sanhueza-Sanzana, Carlos

; Pinheiro Júnior, Francisco Marto Leal

; Martins, Adriano Ferreira

; Correia, Francisco Gustavo Silveira

; de Aguiar, Italo Wesley Oliveira

; Ferreira, Nayane Cavalcante

; Stolow, Jeni

; Rutherford, George

; Teixeira, Maria Gloria

; Pires Neto, Roberto da Justa

; de Almeida, Rosa Livia Freitas

; Coelho, Ivo Castelo Branco

; Frota, Cristiane Cunha

; Kendall, Carl

; Kerr, Ligia Regina Franco Sansigolo

Revista Brasileira de Epidemiologia

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2024, Volume 27 elocation e240025

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720240025

Prevalence and antimicrobial resistance profile of pathogens isolated from patients with urine tract infections admitted to a university hospital in a medium-sized Brazilian city
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Negri, Mariana

; Lima, Bárbara Martins

; Woloszynek, Renata dos Santos Batista Reis

; Molina, Roberto Augusto Silva

; Germano, Carla Maria Ramos

; Melo, Débora Gusmão

; Souza, Leandro Cândido de

; Avó, Lucimar Retto da Silva de

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e3

Resumo: En | Texto: En | PDF: En

ABSTRACT This study aimed to determine the antibiotic profile of microorganisms isolated from urine samples of patients with community urine tract infections (UTI) admitted to the University Hospital of the Federal University of Sao Carlos to support an appropriate local empirical treatment. A retrospective cross-sectional study was conducted from October 2018 to October 2020. Data from 1,528 positive urine cultures for bacterial pathogens and antibiograms were tabulated. Bacterial species prevalence and their resistance profile were analyzed and compared by sex and age. For Gram-negative fermenting bacteria, resistance rates were compared between patients with previous hospitalization and the total of infections caused by this group. For comparisons, the Chi-square test was performed, using Fisher’s exact test when necessary (BioEstat program, adopting p ≤ 0.05). A multivariate analysis was applied to assess the effect of the studied variables in predicting multidrug resistance. Infections were more prevalent in women and older adults. Gram-negative bacteria represented 90.44% of total cultures. In both sexes, E. coli prevalence was significantly higher in adults compared with older adults (p < 0.0001). For several antibiotics, resistance rates were higher in the older adults compared with other ages and in patients with Gram-negative fermenting infections and previous hospitalization compared with the total of infections by this group of bacteria. The closer to the hospitalization, the higher the number of antibiotics with superior resistance rates. Resistance rates for aminoglycosides, carbapenems, ceftazidime, nitrofurantoin, piperacillin+tazobactam, and fosfomycin were less than 20%, considered adequate for empirical treatment. Only hospitalization in the previous 90 days was statistically significant in predicting infections by multidrug-resistant bacteria.

https://doi.org/10.1590/s1678-9946202466003

Immunomodulatory-associated gene transcripts to multipotency of bovine amniotic fluid mesenchymal stem cells
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Baptistella, Jamila Cristina

; Silva, Carolina Gonzales da

; Báo, Sônia Nair

; Panegossi, Letícia Colin

; Cardoso, Tereza Cristina

; Carvalho, Roberto Gameiro de

; Martins, Carlos Frederico

Animal Reproduction

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2024, Volume 21 Nº 1 elocation e20230155

Resumo: En | Texto: En | PDF: En

Abstract The adnexa fetal tissues are sources of mesenchymal stromal cells (MSCs) due to their noninvasive harvest, with all biological material discarded most of the time. MSCs are a promise regarding to their plasticity, self-renewal, differentiation potentials, immunomodulatory and anti-inflammatory properties, which have made clinical stem cell therapy a reality. The present study aimed to characterize and evaluate the immunomodulation ability of bovine mesenchymal cells collected from bovine amniotic fluid (bAFMSCs) isolated and subjected to sixth consecutive culture passages in vitro. The multilineage properties of the bAFMSCs collections confirmed the ability to undergo adipogenic, chondrogenic and osteogenic differentiation. The mesenchymal gene transcription CD106, CD73, CD29, CD90 and CD166 were detected in bAFMSCs, whereas CD34 and CD45 were not detected. Regarding cytokine mRNA expression, IL2, IL6, INFα, INFβ, INFγ, TNFα and TNFβ were downregulated, while IL10 was highly regulated in all studied passages. The present study demonstrated the immunological properties and multipotency of in vitro bAFMSCs collections, and thus, they can be tested in cattle pathological treatments or multiplication by nuclear transfer cloning.

https://doi.org/10.1590/1984-3143-ar2023-0155

“Existe o espaço, mas ao mesmo tempo não existe”: análise do processo de cuidado no tratamento psicofarmacológico na saúde mental
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Pires Júnior, Roberto Carlos

; Marques, Fabrine Costa

; Rocha, Lêda Antunes

; Fonseca, Bárbara Soares

; Martins, Jayne Duarte

; Sampaio, Cristina Andrade

Interface - Comunicação, Saúde, Educação

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2024, Volume 28 elocation e230212

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/interface.230212

Autoinflammatory diseases: a Latin American multicenter study according to age and sex diseases
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Piotto, Daniela Gerent Petry

; Kozu, Katia

; Aikawa, Nádia Emi

; Carneiro, Pedro Lopes

; Katsicas, María Martha

; Oliveira, Sheila Knupp Feitosa de

; Fernandes, Taciana de Albuquerque Pedrosa

; Magalhães, Claudia Saad

; Cunha, Ana Luiza Garcia

; Bica, Blanca Elena Rios Gomes

; Rabelo Júnior, Carlos Nobre

; Battagliotti, Cristina

; Matos, Erica Naomi Naka

; Santos, Flavia Patrícia Sena Teixeira

; Sztajnbok, Flavio Roberto

; Bezrodnik, Liliana

; Bandeira, Marcia

; Rodrigues, Marta Cristine Felix

; Munittis, Pablo García

; Appenzeller, Simone

; Robazzi, Teresa Cristina Martins

; Clemente, Gleice

; Silva, Clovis Artur

; Terreri, Maria Teresa

Revista Paulista de Pediatria

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2024, Volume 42 elocation e2022184

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar as doenças autoinflamatórias (DAI) de acordo com sexo e idade no momento do diagnóstico e a resposta terapêutica em uma grande população. Métodos: Este é um estudo observacional transversal de um registro latino-americano que usou um sistema de dados coletados entre 2015 e 2018. Quaisquer achados alterados ao longo do acompanhamento foram registrados. Os formulários foram traduzidos para os idiomas português e espanhol, incluindo características demográficas, clínicas, laboratoriais, genéticas e de tratamento. Resultados: Incluímos 152 pacientes, sendo 51,3% do sexo masculino e 75% da raça branca. A média de idade de início da doença foi de 2,1 anos (0–15,6 anos) e a média de idade de diagnóstico 6,9 anos (0–21,9 anos); 111 (73%) eram crianças (0–9 anos) e 41 (27%) adolescentes/adultos jovens (10–21 anos). A síndrome de febre periódica, estomatite aftosa, faringite e adenite (PFAPA) ocorreu em 46/152 (30%), osteomielite não bacteriana crônica (CNO) em 32/152 (21%) e febre familiar do Mediterrâneo (FMF) em 24/152 (15,7%). A PFAPA foi significativamente maior em crianças pequenas (38,7 vs. 7,3%, p<0,001), e a CNO, em adolescentes/adultos jovens (13,5 vs. 41,5%, p<0,001). A frequência do sexo feminino foi significativamente maior na CNO (28,4 vs. 14,1%, p=0,031) e menor na FMF (8,1 vs. 23,1%, p=0,011). Os medicamentos mais utilizados foram glicocorticoides, anti-inflamatórios não esteroidais (AINE) e colchicina. O tratamento com glicocorticoides e colchicina foi usado em todas as DAI com resposta boa a moderada. No entanto, as síndromes periódicas associadas à criopirina (CAPS) pareciam não responder aos glicocorticoides. AINE e metotrexato foram os principais medicamentos utilizados no tratamento da CNO. Conclusões: Diferenças de pacientes com DAI foram observadas na população latino-americana em pacientes agrupados por sexo e idade ao diagnóstico da doença. Objetivo (DAI Métodos latinoamericano latino americano 201 2018 registrados espanhol demográficas clínicas laboratoriais Resultados 15 513 51 3 51,3 75 branca 21 2 1 2, 0–15,6 0156 0 6 (0–15, 69 9 6, 0–21,9 0219 (0–21, 11 73% 73 (73% 0–9 09 (0– 4 27% 27 (27% adolescentesadultos adolescentes adultos 10–21 1021 10 (10–2 anos. . periódica aftosa (PFAPA 46152 46 46/15 30%, 30 30% , (30%) (CNO 32152 32 32/15 21% (21% (FMF 24152 24 24/15 15,7%. 157 15,7% 7 (15,7%) 38,7 387 38 (38, vs 7,3% p<0,001, p0001 p p<0,001 001 p<0,001) 13,5 135 13 5 (13, 415 41,5% p<0,001. 28,4 284 28 (28, 141 14 14,1% p=0,031 p0031 031 8,1 81 8 (8, 231 23 23,1% p=0,011. p0011 p=0,011 011 p=0,011) antiinflamatórios anti inflamatórios (AINE moderada entanto CAPS (CAPS Conclusões latinoamericana americana 20 51, 0–15, 015 (0–15 0–21, 021 (0–21 (73 0– (0 (27 10–2 102 (10– 4615 46/1 (30% 3215 32/1 (21 2415 24/1 15,7 (15,7% 38, (38 7,3 p000 p<0,00 00 13, (13 41,5 28, (28 14,1 p=0,03 p003 03 8, (8 23,1 p001 p=0,01 01 0–15 (0–1 0–21 02 (0–2 (7 ( (2 10– (10 461 46/ (30 321 32/ 241 24/ 15, (15,7 (3 7, p00 p<0,0 (1 41, 14, p=0,0 23, 0–1 0–2 (15, p0 p<0, p=0, (15 p<0 p=0 p< p=

ABSTRACT Objective: To evaluate autoinflammatory diseases (AID) according to age at diagnosis and sex, and response to therapy in a large population. Methods: This is a cross-sectional observational study of a Latin American registry using a designed web system for data storage, collected between 2015 and 2018. Any altered findings during follow-up were recorded. The forms were translated into Portuguese and Spanish, including demographic, clinical, laboratory, genetic and treatment characteristics. Results: We included 152 patients, 51.3% male and 75% Caucasian. The median age at disease onset was 2.1 years (0–15.6 years) and median age at diagnosis 6.9 years (0–21.9 years); 111 (73%) were children (0–9 years old), and 41 (27%) were adolescents and young adults (AYA) (10–21 years old). Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome (PFAPA) occurred in 46/152 (30%), chronic non-bacterial osteomyelitis (CNO) in 32/152 (21%), and familial Mediterranean fever (FMF) in 24/152 (15.7%). PFAPA was significantly higher in young children than in AYA (38.7% vs. 7.3%, p<0.001), while CNO were lower (13.5% vs. 41.5%, p<0.001). The frequency of females was significantly higher in CNO (28.4% vs. 14.1%, p=0.031) and lower in FMF (8.1% vs. 23.1%, p=0.011). The most used drugs were glucocorticoids, non-steroidal anti-inflammatory drugs (NSAID), and colchicine. Glucocorticoids and colchicine treatment were used in all AID with good to moderate response. However, cryopyrin-associated periodic syndromes (CAPS) seemed unresponsive to glucocorticoids. NSAIDs and methotrexate were the main medications used to treat CNO. Conclusions: Differences among AID patients were observed in the LA population regarding sex and age at disease diagnosis. Objective (AID Methods crosssectional cross sectional storage 201 2018 followup follow up recorded Spanish demographic clinical laboratory characteristics Results 15 513 51 3 51.3 75 Caucasian 21 2 1 2. 0–15.6 0156 0 6 (0–15. 69 9 6. 0–21.9 0219 (0–21. 11 73% 73 (73% 0–9 09 (0– old, old , old) 4 27% 27 (27% (AYA 10–21 1021 10 (10–2 old. . stomatitis pharyngitis (PFAPA 46152 46 46/15 30%, 30 30% (30%) nonbacterial non bacterial (CNO 32152 32 32/15 21%, 21% (21%) (FMF 24152 24 24/15 15.7%. 157 15.7% 7 (15.7%) 38.7% 387 38 (38.7 vs 7.3% p<0.001, p0001 p p<0.001 001 p<0.001) 13.5% 135 13 5 (13.5 415 41.5% p<0.001. 28.4% 284 28 (28.4 141 14 14.1% p=0.031 p0031 031 8.1% 81 8 (8.1 231 23 23.1% p=0.011. p0011 p=0.011 011 p=0.011) glucocorticoids nonsteroidal steroidal antiinflammatory anti inflammatory NSAID, NSAID (NSAID) However cryopyrinassociated cryopyrin associated CAPS (CAPS Conclusions 20 51. 0–15. 015 (0–15 0–21. 021 (0–21 (73 0– (0 (27 10–2 102 (10– 4615 46/1 (30% 3215 32/1 (21% 2415 24/1 15.7 (15.7% 38.7 (38. 7.3 p000 p<0.00 00 13.5 (13. 41.5 28.4 (28. 14.1 p=0.03 p003 03 8.1 (8. 23.1 p001 p=0.01 01 (NSAID 0–15 (0–1 0–21 02 (0–2 (7 ( (2 10– (10 461 46/ (30 321 32/ (21 241 24/ 15. (15.7 38. (38 7. p00 p<0.0 13. (13 41. 28. (28 14. p=0.0 8. (8 23. 0–1 0–2 (1 (3 (15. p0 p<0. p=0. (15 p<0 p=0 p< p=

https://doi.org/10.1590/1984-0462/2024/42/2022184

Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's disease levodopainduced levodopa induced Parkinsons Parkinson s
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Soares, Nayron Medeiros

; Pereira, Gabriela Magalhães

; Dutra, Ana Carolina Leonardi

; Artigas, Nathalie Ribeiro

; Krimberg, Júlia Schneider

; Monticelli, Bruno Elkfury

; Schumacher-Schuh, Artur Francisco

; Almeida, Rosa Maria Martins de

; Rieder, Carlos Roberto de Mello

Arquivos de Neuro-Psiquiatria

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Jan 2023, Volume 81 Nº 1 Páginas 40 - 46

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Resumo Antecedentes A levodopa é a medicação mais utilizada e eficaz para os sintomas motores da doença de Parkinson (DP); seu uso a longo prazo está associado ao aparecimento de discinesia induzida por levodopa (LID). Acredita-se que o ácido úrico desempenhe um importante papel neuroprotetor na DP. Objetivo Investigar se os níveis séricos de AU estão relacionados com a presença de LID em pacientes com DP. Além disso, investigamos as associações entre os níveis de AU e as características clínicas da DP. Métodos Foram incluídos 81 pacientes com DP (discinesia = 48; sem discinesia = 33) no presente estudo. Uma amostra de sangue foi coletada para avaliar os níveis séricos de AU, a avaliação clínica incluiu os seguintes instrumentos: Avaliação Cognitiva de Montreal (MoCA), Inventário de Depressão de Beck (BDI-II), MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Hoehn and Yahr (HY) e o subitem 4.1 da MDS-UPDRS IV (escore ≥ 1). Informações clínicas relevantes adicionais foram obtidas por meio de um questionário clínico. Resultados Os níveis séricos de AU foram menores no grupo com discinesia quando comparados ao grupo sem discinesia. O mesmo resultado foi encontrado nos níveis de AU de homens e mulheres. A análise multivariada mostrou que níveis mais baixos de ácido úrico foram significativamente associados a ter discinesia (odds ratio [OR] = 0,424; intervalo de confiança (IC) de 95%: 0,221-0,746; p= 0,005). Análises adicionais verificaram que os níveis séricos de AU estão inversamente correlacionados com sintomas depressivos, duração da doença, MDS-UPDRS IV e tempo gasto com discinesia. Uma correlação positiva foi encontrada com a idade de início dos sintomas da DP. Conclusões O presente estudo fornece um possível papel dos níveis séricos de AU na LID presente em pacientes com DP. (DP) LID. . (LID) Acreditase Acredita disso 8 48 33 instrumentos MoCA, MoCA , (MoCA) BDIII, BDIII BDI II (BDI-II) MDSUnified MDS Unified Parkinsons s MDSUPDRS, MDSUPDRS UPDRS (MDS-UPDRS) HY (HY 41 4 1 4. escore 1. 1) clínico mulheres odds OR [OR 0,424 0424 0 424 IC (IC 95% 95 0,2210,746 02210746 0,221 0,746 221 746 0,221-0,746 p 0,005. 0005 0,005 005 0,005) depressivos (DP (LID 3 (MoCA (BDI-II (MDS-UPDRS 0,42 042 42 9 2210 0,2210,74 0221074 0221 0,22 0746 0,74 22 74 0,221-0,74 000 0,00 00 0,4 04 0,2210,7 022107 022 0,2 074 0,7 2 7 0,221-0,7 0,0 0, 0,2210, 02210 02 07 0,221-0, 0,2210 0,221-0 0,221-

Abstract Background Levodopa is the most used and effective medication for motor symptoms of Parkinson disease (PD), its long-term use is associated with the appearance of levodopa-induced dyskinesia (LID). Uric acid (UA) is believed to play an important neuroprotective role in PD. Objective To investigate if serum UA levels are related with the presence of LIDs in PD patients. Also, we investigated the associations among UA levels and clinical features of PD. Methods We enrolled 81 PD patients (dyskinesia = 48; no dyskinesia = 33) in the present study. A blood sample was collected to evaluate serum UA levels, clinical evaluation included the following instruments: Montreal Cognitive Assessment (MoCA), Beck Depression Inventory II (BDI-II), MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Hoehn and Yahr (HY), and the sub-item 4.1 of MDS-UPDRS IV (score ≥ 1). Additional relevant clinical information was obtained by a clinical questionnaire. Results Serum UA levels were lower in the dyskinesia group when compared with the no dyskinesia group. The same result was found in the UA levels of both men and women. The multivariate analysis showed lower uric acid levels were significantly associated with having dyskinesia (odds ratio [OR] = 0.424; 95% confidence interval [CI]: 0.221-0.746; p= 0.005). Additional analysis verified that serum UA levels are inversely correlated with depressive symptoms, disease duration, MDS-UPDRS IV and time spent with dyskinesia. A positive correlation was found with age at onset of PD symptoms. Conclusions The present study provides a possible role of serum UA levels in LID present in PD patients. PD, , (PD) longterm long term levodopainduced levodopa induced LID. . (LID) (UA Also 8 48 33 instruments MoCA, MoCA (MoCA) BDIII, BDIII BDI (BDI-II) MDSUnified MDS Unified Parkinsons s MDSUPDRS, MDSUPDRS UPDRS (MDS-UPDRS) HY, HY (HY) subitem sub item 41 4 1 4. score 1. 1) questionnaire women odds OR [OR 0.424 0424 0 424 95 CI [CI] 0.2210.746 02210746 0.221 0.746 221 746 0.221-0.746 p 0.005. 0005 0.005 005 0.005) duration (PD (LID 3 (MoCA (BDI-II (MDS-UPDRS (HY 0.42 042 42 9 [CI 2210 0.2210.74 0221074 0221 0.22 0746 0.74 22 74 0.221-0.74 000 0.00 00 0.4 04 0.2210.7 022107 022 0.2 074 0.7 2 7 0.221-0.7 0.0 0. 0.2210. 02210 02 07 0.221-0. 0.2210 0.221-0 0.221-

https://doi.org/10.1055/s-0043-1761294

Budbreak of pecan cultivars subject to artificial chill
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Crosa, Claudia Farela Ribeiro

; Marco, Rudinei De

; Barreto, Caroline Farias

; Souza, Rafaela Schmidt de

; Yamamoto, Robson Ryu

; Martins, Carlos Roberto

Revista Ceres

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Jan 2023, Volume 70 Nº 1 Páginas 42 - 50

Resumo: En | Texto: En | PDF: En

ABSTRACT Chill is a limiting factor in commercial production of temperate fruit due to their dormancy mechanism. Thus, knowledge of chill requirements of cultivars is important to reach successful production. This study aimed at evaluating responses given by different pecan cultivars subject to artificial chill. Pecan branches were collected from twelve 9-year-old cultivars – Success, Shoshoni, Farley, Elliott, Mohawk, Jackson, Desirable, Barton, Importada, Shawnee, Choctaw and Melhorada – in two orchards located in Canguçu, Rio Grande do Sul (RS) state, Brazil, in 2017 and 2018. Treatments consisted in exposing branches to 0, 250, 500, 750 and 1,000 chill hours in a cold chamber (4.0 ± 0.5 °C) and then taking them to the germination chamber (25 ± 0.5 °C and photoperiod of 16 hours of light) until the end of the evaluations. Final budbreak rate (FBR) of every cultivar and the number of days required to reach 50% of budbreak (DD50%) were evaluated. Chill required by cultivars to start budbreak varied in both years under evaluation. Both FBR and DD50 were higher in 2017 than in 2018. Due to high variation in FBR and DD50, chill requirements of pecan cultivars could not be clearly determined by the biological method. mechanism Thus 9yearold yearold 9 year old Success Shoshoni Farley Elliott Mohawk Jackson Desirable Barton Importada Shawnee Canguçu RS (RS state Brazil 201 2018 0 250 500 75 1000 1 000 1,00 4.0 40 4 (4. 05 5 0. C 25 (2 light evaluations (FBR 50 DD50% DD (DD50% evaluated evaluation DD5 method 20 7 100 00 1,0 4. (4 2 ( (DD50 10 1, (DD5 (DD

https://doi.org/10.1590/0034-737x202370010005

10.

Numerical Prediction for the Effects of Welding Interpass Temperature on the Thermal History and Microstructure of Duplex Stainless Steels
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Xavier, Carlos Roberto

; Delgado Junior, Horácio Guimarães

; Rebello, Matheus Gomes

; Lisbôa, Raí Ramos

; Silva, Ana Carolina Martins

; Castro, José Adilson de

Materials Research

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2023, Volume 26 elocation e20220529

Resumo: En | Texto: En | PDF: En

Numerical simulation was used to predict the thermal behavior and the resulting microstructure at the heat-affected zone (HAZ) of a 170 mm diameter and 3.5 mm thickness super duplex stainless steel (SDSS) UNS S32750 tube. In order to evaluate the thermal response from the model, a usual welding situation involving interpass temperature (IT) and its influence on the HAZ microstructure was exploited. Thus, two superimposed autogenous welding passes were simulated, the first clockwise with the tube in the room temperature and the second, counterclockwise, with the tube at the temperature of 250oC. Even subjected to successive thermal cycles and high interpass temperature, the proportion and morphology of the phases at the HAZ and Fusion Zone (FZ) did not present significant differences when comparing the two welding passes. Meanwhile, nitrogen losses should be avoided during welding in order to obtain a balanced microstructure in DSS welds, contributing to guarantee satisfactory toughness in addition to resistance to pitting corrosion. The predictions from the simulation were validated by using experimental results obtained from the autogenous TIG (Tungsten Inert Gas) process. heataffected heat affected (HAZ 17 35 3 5 3. SDSS (SDSS S S3275 model IT (IT exploited Thus simulated second counterclockwise 250oC oC FZ (FZ Meanwhile welds corrosion Tungsten Gas process 1 S327 S32 S3

https://doi.org/10.1590/1980-5373-mr-2022-0529

11.

Bond strength of bulk fill composite to teeth prepared with Er:YAG laser ErYAG Er YAG
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Benati, Marcos Roberto de Lima

; Baioni, Jean Carlos

; Souza, Amanda Guerra Cavalcante de

; Ferraz, Laura Nobre

; Oliveira, Ana Luisa Botta Martins de

; Vitti, Rafael Pino

; Scatolin, Renata Siqueira

Brazilian Journal of Oral Sciences

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2023, Volume 22 elocation e238727

Resumo: En | Texto: En | PDF: En

Aim The present in vitro study aimed to evaluate the bond strength of a bulk fill composite on dentin surfaces prepared with the Er: YAG laser. Methods Twenty-four permanent third molars were selected and divided into 2 groups: CP - Conventional preparation with high-speed handpiece (control) and LA (laser) - Preparation with Er: YAG laser. The occlusal surface was removed to expose coronal dentin, which was subsequently prepared with a high-speed handpiece or Er: YAG laser (350mJ, 4Hz, 1.5 ml/min water flow). Both groups were restored with Filtek One Bulk Fill (3M ESPE) composite resin. After 24 hours, the samples were evaluated for microtensile bond strength (µTBS), fracture pattern, and scanning electron microscopy (SEM). Results The data obtained in the µTBS test were submitted to t-test (α=0.05). The results showed no difference in µTBS when the different types of cavity preparation were compared (ρ=0.091). Fracture patterns revealed the prevalence of cohesive fracture in composite resin in CP (83.3%) and adhesive fracture in LA (92.1%). In the SEM analysis, the LA group demonstrated the presence of gaps between the composite resin and the irradiated dentin surface. The hybrid layer exhibited more regularity with the presence of longer and uniform resin tags in the CP group. Conclusion The type of cavity preparation did not influence the values of bulk fill composite resin µTBS to dentin. Fracture patterns and scanning electron microscopy analyses suggested less interference at the adhesive interface in preparations performed using CP. Er Twentyfour Twenty four highspeed high speed control (control (laser 350mJ, 350mJ mJ (350mJ 4Hz Hz 15 1 5 1. mlmin ml min flow. flow . flow) 3M M ESPE hours µTBS, , (µTBS) pattern SEM. (SEM) ttest t α=0.05. α005 α α=0.05 0 05 (α=0.05) ρ=0.091. ρ0091 ρ ρ=0.091 091 (ρ=0.091) 83.3% 833 83 3 (83.3% 92.1%. 921 92.1% 92 (92.1%) analysis (µTBS (SEM α00 α=0.0 (α=0.05 ρ009 ρ=0.09 09 (ρ=0.091 83.3 8 (83.3 92.1 9 (92.1% α0 α=0. (α=0.0 ρ00 ρ=0.0 (ρ=0.09 83. (83. 92. (92.1 α=0 (α=0. ρ0 ρ=0. (ρ=0.0 (83 (92. α= (α=0 ρ=0 (ρ=0. (8 (92 (α= ρ= (ρ=0 ( (9 (α (ρ= (ρ

https://doi.org/10.20396/bjos.v22i00.8668727

12.

Acompanhamento de Dois Anos de Pacientes com Cardiopatia Isquêmica Crônica em um Centro Especializado no Brasil
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Moreira, Eduardo Martelli

; Pinesi, Henrique Trombini

; Martins, Eduardo Bello

; Pitta, Fábio Grunspun

; Bolta, Paula Mathias Paulino

; Segre, Carlos Alexandre Wainrober

; Favarato, Desiderio

; Rached, Fabiana Hanna

; Hueb, Whady Armindo

; Lima, Eduardo Gomes

; Kalil Filho, Roberto

; Garzillo, Cibele Larrosa

; Serrano Jr, Carlos Vicente

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 10 elocation e20220440

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A incidência de eventos cardiovasculares em pacientes com doença cardíaca isquêmica crônica (DCIC) pode variar significativamente entre os países. Embora populoso, o Brasil é frequentemente sub-representado nos registros internacionais. Objetivos Este estudo teve como objetivo descrever a qualidade do atendimento e a incidência de eventos cardiovasculares em dois anos, além de fatores prognósticos associados em pacientes com DCIC em um centro terciário de saúde pública no Brasil. Métodos Pacientes com DCIC que compareceram para avaliação clínica no Instituto do Coração (São Paulo, Brasil) foram cadastrados e acompanhados por dois anos. O desfecho primário foi um composto de infarto do miocárdio (IM), acidente vascular encefálico ou morte. Um nível de significância de 0,05 foi adotado. Resultados De janeiro de 2016 a dezembro de 2018, 625 participantes foram incluídos no estudo. As características basais mostram que 33,1% eram mulheres, a idade mediana era de 66,1 [59,6 – 71,9], 48,6% tinham diabetes, 83,1% tinham hipertensão, 62,6% tinham IM prévio e 70,4% passaram por algum procedimento de revascularização. Em um acompanhamento mediano de 881 dias, 37 (7,05%) desfechos primários foram observados. Após ajustes, idade, acidente vascular encefálico prévio e colesterol LDL foram independentemente associados ao desfecho primário. Comparando a linha de base com o acompanhamento, os participantes relataram alívio da angina com base na escala da Sociedade Cardiovascular Canadense (SCC) de acordo com as seguintes porcentagens: 65,7% vs. 81,7% eram assintomáticos e 4,2% vs. 2,9% eram SCC 3 ou 4 (p < 0,001). Eles também relataram melhor qualidade na prescrição de medicamentos: 65,8% vs. 73,6% (p < 0,001). No entanto, não houve melhora no colesterol LDL ou no controle da pressão arterial. Conclusão O presente estudo mostra que pacientes com DCIC apresentaram uma incidência de 7,05% do desfecho primário composto em um período de dois anos, sendo a diminuição do colesterol LDL o único fator de risco modificável associado ao prognóstico. (DCIC países populoso subrepresentado sub representado internacionais anos São Paulo IM, , (IM) morte 005 0 05 0,0 adotado 201 2018 62 331 33 1 33,1 mulheres 661 66 66, 59,6 596 59 6 [59, 71,9, 719 71,9 71 9 71,9] 486 48 48,6 diabetes 831 83 83,1 hipertensão 626 62,6 704 70 70,4 revascularização 88 dias 705 7 (7,05% observados ajustes (SCC porcentagens 657 65 65,7 vs 817 81 81,7 42 2 4,2 29 2,9 p 0,001. 0001 0,001 . 001 0,001) medicamentos 658 8 65,8 736 73 73,6 entanto arterial 7,05 prognóstico (IM 00 0, 20 33, 59, 5 [59 71, 48, 83, 62, 70, (7,05 65, 81, 4, 2, 000 0,00 73, 7,0 [5 (7,0 7, [ (7, (7 (

Abstract Background The incidence of cardiovascular events in patients with chronic ischemic heart disease (CIHD) may vary significantly among countries. Although populous, Brazil is often underrepresented in international records. Objectives This study aimed to describe the quality of care and the two-year incidence of cardiovascular events and associated prognostic factors in CIHD patients in a tertiary public health care center in Brazil. Methods Patients with CIHD who reported for clinical evaluation at Instituto do Coração (São Paulo, Brazil) were registered and followed for two years. The primary endpoint was a composite of myocardial infarction (MI), stroke, or death. A significance level of 0.05 was adopted. Results From January 2016 to December 2018, 625 participants were included in the study. Baseline characteristics show that 33.1% were women, median age 66.1 [59.6 – 71.9], 48.6% had diabetes, 83.1% had hypertension, 62.6% had previous MI, and 70.4% went through some revascularization procedure. At a median follow-up (FU) of 881 days, we noted 37 (7.05%) primary endpoints. After adjustments, age, previous stroke, and LDL-cholesterol were independently associated with the primary endpoint. Comparing baseline versus FU, participants experienced relief of angina based on the Canadian Cardiovascular Society (CCS) scale according to the following percentages: 65.7% vs. 81.7% were asymptomatic and 4.2% vs. 2.9% CCS 3 or 4 (p < 0.001). They also experienced better quality of medication prescription: 65.8% vs. 73.6% (p < 0.001). However, there was no improvement in LDL-cholesterol or blood pressure control. Conclusion This study shows that CIHD patients had a two-year incidence of the primary composite endpoint of 7.05%, and the reduction of LDL-cholesterol was the only modifiable risk factor associated with prognosis. (CIHD countries populous records twoyear year São Paulo years MI , (MI) stroke death 005 0 05 0.0 adopted 201 2018 62 331 33 1 33.1 women 661 66 66. 59.6 596 59 6 [59. 71.9, 719 71.9 71 9 71.9] 486 48 48.6 diabetes 831 83 83.1 hypertension 626 62.6 704 70 70.4 procedure followup follow up FU (FU 88 days 7.05% 705 7 (7.05% endpoints adjustments LDLcholesterol LDL cholesterol (CCS percentages 657 65 65.7 vs 817 81 81.7 42 2 4.2 29 2.9 p 0.001. 0001 0.001 . 001 0.001) prescription 658 8 65.8 736 73 73.6 However control prognosis (MI 00 0. 20 33. 59. 5 [59 71. 48. 83. 62. 70. 7.05 (7.05 65. 81. 4. 2. 000 0.00 73. [5 7.0 (7.0 [ 7. (7. (7 (

https://doi.org/10.36660/abc.20220440

13.

Genetic variability in pecan genotypes in Brazil
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Souza, Rafaela Schmidt de

; Martins, Carlos Roberto

; Castro, Caroline Marques

; Lima, Natércia Lobato Pinheiro

; Mello-Farias, Paulo Celso de

Revista Ceres

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2023, Volume 70 Nº 5 elocation e70504

Resumo: En | Texto: En | PDF: En

ABSTRACT Pecan crops has been expanding in recent years, mainly in southern Brazil. Genotypes that compose Brazilian orchards come from the USA and from selections of plants made by Brazilian producers. This study aimed to characterize with microsatellite markers pecan cultivars registered for cultivation in Brazil, including some selections made in the country. It is important to know the genetic variability of the pecan tree, as it facilitates the identification of possible phytotechnical deficiencies due to the genetic similarity between the plants, in addition to helping in the conservation of the species, among other. Thirty-four, out of forty collected accessions, were genotyped with 11 selected SSR (Simple Sequence Repeats) loci. Twenty-four polymorphic alleles were identified. The genetic similarity matrix, based on the Jaccard coefficient, ranged from 0.125 to 1.0; general mean of similarity was 0.46. The cluster analysis, which was carried out by the Unweighted Pair Group Method with Arithmetic Mean (UPGMA), classified pecan accessions into four main groups. Results showed that there is high genetic variability in germplasm evaluated, although some accessions may be duplicates. years Brazil producers country tree species other Thirtyfour, Thirtyfour Thirty four, Thirty-four 1 Simple Repeats loci Twentyfour Twenty identified matrix coefficient 0125 0 125 0.12 1.0 10 046 46 0.46 analysis UPGMA, UPGMA , (UPGMA) groups evaluated duplicates 012 12 0.1 1. 04 4 0.4 (UPGMA 01 0.

https://doi.org/10.1590/0034-737x202370050004

14.

Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023 202 20 2
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Marin-Neto, José Antonio

; Rassi Jr, Anis

; Oliveira, Gláucia Maria Moraes

; Correia, Luís Claudio Lemos

; Ramos Júnior, Alberto Novaes

; Luquetti, Alejandro Ostermayer

; Hasslocher-Moreno, Alejandro Marcel

; Sousa, Andréa Silvestre de

; Paola, Angelo Amato Vincenzo de

; Sousa, Antônio Carlos Sobral

; Ribeiro, Antonio Luiz Pinho

; Correia Filho, Dalmo

; Souza, Dilma do Socorro Moraes de

; Cunha-Neto, Edecio

; Ramires, Felix Jose Alvarez

; Bacal, Fernando

; Nunes, Maria do Carmo Pereira

; Martinelli Filho, Martino

; Scanavacca, Maurício Ibrahim

; Saraiva, Roberto Magalhães

; Oliveira Júnior, Wilson Alves de

; Lorga-Filho, Adalberto Menezes

; Guimarães, Adriana de Jesus Benevides de Almeida

; Braga, Adriana Lopes Latado

; Oliveira, Adriana Sarmento de

; Sarabanda, Alvaro Valentim Lima

; Pinto, Ana Yecê das Neves

; Carmo, Andre Assis Lopes do

; Schmidt, Andre

; Costa, Andréa Rodrigues da

; Ianni, Barbara Maria

; Markman Filho, Brivaldo

; Rochitte, Carlos Eduardo

; Macêdo, Carolina Thé

; Mady, Charles

; Chevillard, Christophe

; Virgens, Cláudio Marcelo Bittencourt das

; Castro, Cleudson Nery de

; Britto, Constança Felicia De Paoli de Carvalho

; Pisani, Cristiano

; Rassi, Daniela do Carmo

; Sobral Filho, Dário Celestino

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Mesquita, Evandro Tinoco

; Mendes, Fernanda de Souza Nogueira Sardinha

; Gondim, Francisca Tatiana Pereira

; Silva, Gilberto Marcelo Sperandio da

; Peixoto, Giselle de Lima

; Lima, Gustavo Glotz de

; Veloso, Henrique Horta

; Moreira, Henrique Turin

; Lopes, Hugo Bellotti

; Pinto, Ibraim Masciarelli Francisco

; Ferreira, João Marcos Bemfica Barbosa

; Nunes, João Paulo Silva

; Barreto-Filho, José Augusto Soares

; Saraiva, José Francisco Kerr

; Lannes-Vieira, Joseli

; Oliveira, Joselina Luzia Menezes

; Armaganijan, Luciana Vidal

; Martins, Luiz Cláudio

; Sangenis, Luiz Henrique Conde

; Barbosa, Marco Paulo Tomaz

; Almeida-Santos, Marcos Antonio

; Simões, Marcos Vinicius

; Yasuda, Maria Aparecida Shikanai

; Moreira, Maria da Consolação Vieira

; Higuchi, Maria de Lourdes

; Monteiro, Maria Rita de Cassia Costa

; Mediano, Mauro Felippe Felix

; Lima, Mayara Maia

; Oliveira, Maykon Tavares de

; Romano, Minna Moreira Dias

; Araujo, Nadjar Nitz Silva Lociks de

; Medeiros, Paulo de Tarso Jorge

; Alves, Renato Vieira

; Teixeira, Ricardo Alkmim

; Pedrosa, Roberto Coury

; Aras Junior, Roque

; Torres, Rosalia Morais

; Povoa, Rui Manoel dos Santos

; Rassi, Sergio Gabriel

; Alves, Silvia Marinho Martins

; Tavares, Suelene Brito do Nascimento

; Palmeira, Swamy Lima

; Silva Júnior, Telêmaco Luiz da

; Rodrigues, Thiago da Rocha

; Madrini Junior, Vagner

; Brant, Veruska Maia da Costa

; Dutra, Walderez Ornelas

; Dias, João Carlos Pinto

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 6 elocation e20230269

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.36660/abc.20230269

15.

Genetic cause and effect interrelationships for grain quality attributes of irrigated rice
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Facchinello, Paulo Henrique Karling

; Carvalho, Ivan Ricardo

; Streck, Eduardo Anibele

; Aguiar, Gabriel Almeida

; Goveia, Janaína

; Feijó, Michele

; Pereira, Roberto Ramos

; Fagundes, Paulo Ricardo Reis

; Loro, Murilo Vieira

; Maia, Luciano Carlos da

; Magalhães Júnior, Ariano Martins de

Pesquisa Agropecuária Brasileira

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2023, Volume 58 elocation e03252

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste trabalho foi determinar as correlações genéticas e as associações diretas e indiretas de caracteres agronômicos e atributos de qualidade de grãos com a percentagem de grãos inteiros em arroz irrigado por inundação. O experimento foi conduzido em dois ambientes, em delineamento de blocos ao acaso, com três repetições, tendo-se utilizado 23 genótipos de arroz irrigado. Os caracteres avaliados foram: percentagem de grãos inteiros, comprimento da cariopse, largura da cariopse, comprimento da panícula, peso da panícula, peso de mil grãos, dias para floração, percentagem de grãos com “barriga branca” e grãos gessados, área gessada total, brancura total, brancura vítrea e defeitos de coloração. A percentagem de grãos com “barriga branca” e área gessada total correlacionaram-se positivamente, enquanto a percentagem de grãos com “barriga branca” e gessada e brancura vítrea correlacionaram-se negativamente. Os caracteres largura da cariopse, percentual de grãos com “barriga branca” e gessada, peso da panícula e peso de mil grãos apresentaram efeitos indiretos sobre a resposta de rendimento de grãos inteiros de acordo com área total gessada e brancura total. Área total gessada e brancura total são os fatores que mais influenciam negativamente a percentagem de grãos inteiros de acordo com as correlações genotípicas e os efeitos diretos. inundação ambientes acaso repetições tendose tendo se 2 foram cariopse floração barriga branca gessados coloração correlacionaramse correlacionaram positivamente diretos

Abstract The objective of this work was to determine the genetic correlations and the direct and indirect associations of agronomic traits and grain quality attributes with the percentage of whole grains in flood irrigated rice. The experiment was carried out in two environments, in a randomized complete block design with three replicates, using 23 irrigated rice genotypes. The evaluated traits were: percentage of whole grains, caryopsis length, caryopsis width, panicle length, panicle weight, 1,000 grain weight, days to flowering, percentage of chalky grains with white belly, total chalky area, total whiteness, vitreous whiteness, and defects in coloring. The percentage of grains with white belly and total chalky area were positively correlated, whereas the percentage of grains with white belly and vitreous whiteness were negatively correlated. The traits caryopsis width, percentage of chalky grains with white belly, panicle weight, and 1,000 grain weight showed indirect effects on whole-grain yield response according to total chalky area and total whiteness. Total chalky area and total whiteness are the factors that most negatively influence the percentage of whole grains according to the genotypic correlations and direct effects. environments replicates 2 genotypes length width 1000 1 000 1,00 flowering coloring correlated wholegrain 100 00 1,0 10 0 1,

https://doi.org/10.1590/s1678-3921.pab2023.v58.03252

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