ABSTRACT The design and visualization of the distribution of atoms in a fraction of space through the application of software allows us to increase the understanding of the structure of materials and the elaboration of theoretical propositions. The purpose of this work was to develop a procedure for the application of the GeoGebra 3D software as a tool for designing crystalline structures, from the Mathematics subject for Chemical Engineering students. A workshop called GeoCristal was held to reflect experiences on the use of GeoGebra 3D. Based on a sequence of tasks, the students designed a BCC crystal structure related to alpha iron in the software. The experience demonstrated the usefulness of the software for the design of crystalline structures. It made possible to promote and systematize essential contents of Materials Engineering. Managed to increase students' motivation for Mathematics. The study reflected the importance of the use of ICTs and basic subjects in the training of chemical engineers.

RESUMEN El diseño y visualización de la distribución de los átomos en una fracción del espacio mediante la aplicación de software, permite elevar la comprensión de la estructura de los materiales y la elaboración de proposiciones teóricas. El propósito de este trabajo consistió en desarrollar un procedimiento para la aplicación del software GeoGebra 3D como herramienta de diseño de estructuras cristalinas, desde la asignatura de Matemática para estudiantes de Ingeniería Química. Se realizó un taller denominado GeoCristal para reflejar las experiencias sobre el empleo de GeoGebra 3D. A partir de una secuencia de tareas, los estudiantes diseñaron en el software una estructura cristalina BCC relacionada con el hierro alfa. La experiencia demostró la utilidad del software para el diseño en estructuras cristalinas. Permitió fomentar y sistematizar contenidos imprescindibles de la Ingeniería de los Materiales. Logró aumentar la motivación de los estudiantes por las Matemáticas. El estudio reflejó la importancia del uso de las TICs y de las asignaturas básicas en la formación del ingeniero químico.

Abstract The agricultural sector is among the most benefited by the Internet of Things (IoT) expansion since it allows collecting and managing a large amount of data about a crop's environment. This article presents the results of designing and testing a prototype monitoring system for agricultural variables, which can be stored and consulted in the cloud. Low-cost sensors and processing systems were easily adaptable to agricultural environments. The results confirmed the viability of implementing this system without resorting to complex technological and computational tools.

Resumen El sector agrícola se encuentra entre los más beneficiados por la expansión del Internet de las Cosas (IoT), ya que permite recopilar y gestionar una gran cantidad de datos sobre el entorno de un cultivo. Este artículo presenta los resultados del diseño y la prueba de un prototipo de sistema de monitoreo de variables agrícolas, las cuales pueden almacenarse y consultarse en la nube. Se utilizaron sensores y sistemas de procesamiento de bajo costo y fácilmente adaptables a entornos agrícolas. Los resultados obtenidos confirman la viabilidad de implementar estos sistemas sin recurrir a herramientas tecnológicas y computacionales complejas.

Abstract Objective: The aim of this study was to assess the risk factors associated with 30-day hospital readmissions after a cholecystectomy. Methods: We conducted a case–control study, with data obtained from UC-Christus from Santiago, Chile. All patients who underwent a cholecystectomy between January 2015 and December 2019 were included in the study. We identified all patients readmitted after a cholecystectomy and compared them with a randomized control group. Univariate and multivariate analyses were conducted to identify risk factors. Results: Of the 4866 cholecystectomies performed between 2015 and 2019, 79 patients presented 30-day hospital readmission after the surgical procedure (1.6%). We identified as risk factors for readmission in the univariate analysis the presence of a solid tumor at the moment of cholecystectomy (OR = 7.58), high pre-operative direct bilirubin (OR = 2.52), high pre-operative alkaline phosphatase (OR = 3.25), emergency admission (OR = 2.04), choledocholithiasis on admission (OR = 4.34), additional surgical procedure during the cholecystectomy (OR = 4.12), and post-operative complications. In the multivariate analysis, the performance of an additional surgical procedure during cholecystectomy was statistically significant (OR = 4.24). Conclusion: Performing an additional surgical procedure during cholecystectomy was identified as a risk factor associated with 30-day hospital readmission.

Resumen Objetivo: El objetivo de este estudio fue evaluar los factores de riesgo asociados al reingreso hospitalario en los primeros 30 días post colecistectomía. Métodos: Estudio de casos-controles con datos obtenidos del Hospital Clínico de la UC-Christus, Santiago, Chile. Se incluyeron las colecistectomías realizadas entre los años 2015-2019. Se consideraron como casos aquellos pacientes que reingresaron en los 30 primeros días posterior a una colecistectomía. Se realizó un análisis univariado y multivariado de diferentes posibles factores de riesgo. Resultados: De un total de 4866 colecistectomías, 79 pacientes presentaron reingreso hospitalario. Los resultados estadísticamente significativos en el análisis univariado fueron; tumor sólido al momento de la colecistectomía (OR = 7.58) bilirrubina directa preoperatoria alterada (OR = 2.52), fosfatasa alcalina preoperatoria alterada (OR = 3.25), ingreso de urgencia (OR = 2.04), coledocolitiasis al ingreso (OR = 4.34) realización de otros procedimientos (OR = 4.12) y complicaciones postoperatorias. En el análisis multivariado sólo la realización de otro procedimiento durante la colecistectomía fue estadísticamente significativa (OR = 4.24). Conclusión: La realización de otros procedimientos durante la colecistectomía es un factor de riesgo de reingreso hospitalario en los 30 días posteriores a la colecistectomía.

Resumen Objetivo: Describir la evolución de las cadenas livianas libres séricas (CLL) en el período comprendido entre el trasplante cardíaco ortotópico (TCO) y el trasplante de células progenitoras hematopoyéticas (TCPH), la respuesta hematológica al año tras el TCPH y el tratamiento quimioterápico e inmunosupresor en pacientes con amiloidosis AL. Método: Serie de casos de pacientes consecutivos con diagnóstico de amiloidosis AL que recibieron TCO seguido de TCPH del Registro Institucional de Amiloidosis del Hospital Italiano de Buenos Aires, entre enero de 2010 y noviembre de 2021. Se reportaron los valores de CLL entre trasplantes y al año del TCPH. Las variables cuantitativas se describieron como mediana e intervalo intercuartil, y las variables categóricas como frecuencias absolutas y relativas. Resultados: De 106 pacientes con amiloidosis AL, seis tuvieron TCO seguido de TCPH. La mediana de edad fue de 55 años. La mayoría eran hombres (n = 5). En el período entre trasplantes, la CLL involucrada disminuyó en dos pacientes y se mantuvo estable en tres. Todos lograron la remisión hematológica completa al año del TCPH. Un solo paciente presentó recaída en el órgano sólido trasplantado. Tacrolimus, micofenolato de mofetilo y corticoides fue el esquema inmunosupresor utilizado después del TCO. Conclusiones: El TCO representa una opción de tratamiento en pacientes con falla cardíaca grave por amiloidosis, permitiendo luego un tratamiento intensivo con quimioterapia de inducción y TCPH. Si bien faltan estudios, la terapia inmunosupresora después del TCO podría tener algún efecto sobre las células plasmáticas clonales.

Abstract Objective: To describe the evolution of serum free light chains (FLC) in the period between orthotopic heart transplantation (OHT) and autologous stem cell transplantation (ASCT), the hematological response one year after ASCT and chemotherapy and immunosuppressive treatment in patients with AL amyloidosis. Method: Case series of consecutive patients diagnosed with AL amyloidosis who received OHT followed by ASCT from the Institutional Registry of Amyloidosis of the Italian Hospital of Buenos Aires, between January 2010 and November 2021. FLC values between transplants and at year post ASCT. Quantitative variables were described with their median and interquartile range. Categorical variables as absolute and relative frequencies. Results: Of 106 patients with AL amyloidosis, 6 had an OHT followed by ASCT. The median age was 55 years. Most were men (n = 5). In the period between transplants, the involved CLL decreased in two patients and remained stable in three. All achieved complete hematologic remission 1 year after ASCT. A single patient presented relapse in the transplanted solid organ. Tacrolimus, mycophenolate mofetil, and corticosteroids were the immunosuppressive regimen used after OHT. Conclusions: OHT represents a treatment option in patients with severe heart failure due to amyloidosis, allowing later intensive treatment with induction chemotherapy and ASCT. Although studies are lacking, immunosuppressive therapy after OHT might have some effect on clonal plasma cells.

Resumen. El Síndrome Respiratorio y Reproductivo del Cerdo (PRRS) es una enfermedad endémica en porcinos que tiende a la cronicidad. Los esfuerzos se centran en prevención y control para minimizar el daño, pues no existe tratamiento. Se evaluó el efecto de la adición de ácido docosahexaenoico (DHA) y oleorresina de cúrcuma y capsicum (EP, extractos de plantas) en la alimentación de cerdas reproductoras afectadas con PRRS sobre su desempeño productivo, de salud y en su progenie. Cuarenta y ocho cerdas de primer parto se distribuyeron al azar en cuatro tratamientos (Tr1, testigo; Tr2, DHA; Tr3, EP; Tr4, DHA+EP). El ensayo con el segundo parto siguió el mismo diseño. Tr3 y Tr4 obtuvieron más peso de lechones al nacer en ambos partos (P < 0.05) que los demás. En ambos partos, la adición de DHA y EP resultó en menos cantidad de momias (P < 0.05) y menor costo que los otros tratamientos. Tr3 tuvo mayor número de lechones vivos en ambos partos, mientras que Tr4 solo en el segundo parto (P < 0.05). En el primer parto, se destetaron más lechones en Tr2 y Tr3 (P > 0.05); pero Tr2 superó a los demás en el segundo parto (P > 0.05). Por ELISA, todos los cerdos desarrollaron anticuerpos contra PRRS. Los grupos que recibieron DHA y/o EP tuvieron concentraciones séricas de IgG superiores al testigo (P < 0.05). Se concluye que la adición de DHA y EP mejora la respuesta productiva y mayores concentraciones de IgG en ambos partos, además de reducir el costo de producción de las cerdas.

Abstract. Pig Respiratory and Reproductive Syndrome (PRRS) is an endemic disease in pigs that tends to become chronic. Efforts are focused on prevention and control to minimize damage, as no treatment exists. The effect of adding docosahexaenoic acid (DHA) and turmeric oleoresin and capsicum (plant extracts, PE) in the feeding of breeding sows affected with PRRS on their productive performance, health and progeny was evaluated. Forty-eight first-parturition shows were randomly distributed into four treatments (Tr1, control; Tr2, DHA; Tr3, PE; Tr4, DHA+PE). The second parturition assay followed the same design. Tr3 and Tr4 got more piglet weight at birth in both parturitions (P < 0.05) than the others. In both deliveries, the addition of DHA and PE resulted in fewer mummies (P < 0.05) and lower cost than the other treatments. Tr3 had a higher number of live piglets in both parturitions, while Tr4 only got that in the second parturition (P < 0.05). More piglets were weaned in Tr2 and Tr3 (P > 0.05) in the first parturition; but Tr2 outperformed the others in the second parturition (P > 0.05). By ELISA, all pigs developed antibodies against PRRS. The groups receiving DHA and/or PE had higher serum IgG concentrations than control (P < 0.05). It is concluded that the addition of DHA and PE improves the productive response and induced higher concentrations of IgG in both parturitions, in addition to reducing the production cost of sows.

ABSTRACT Posterior reversible encephalopathy syndrome is a clinical-radiological disorder, which usually progresses with classical acute neurological symptoms (visual impairment, acute headache, altered level of consciousness, seizures, and even focal neurological deficit). A case presented with a review of the currently available literature is reported in this article.

RESUMEN El síndrome de encefalopatía posterior reversible es un trastorno clínico-radiológico que suele cursar con síntomas neurológicos agudos clásicos (alteración visual, cefalea aguda, alteración del nivel de conciencia, convulsiones e incluso déficit neurológico focal). En este artículo se presenta un caso junto con una revisión de la literatura disponible en la actualidad.

Resumen La diabetes mellitus (DM) es una enfermedad crónica muy prevalente. Dentro de los tratamientos para la DM se encuentra la insulina que es el agente antidiabético más potente, sin embargo, una proporción significativa de pacientes no logra alcanzar el objetivo de hemoglobina glicosilada (HbA1c). Los errores en la aplicación de insulina son un factor importante y corregible en muchos casos. Se presenta el caso de una paciente con DM, antecedentes de neuropatía diabética, enfermedad renal crónica estadio V en hemodiálisis, hipertensión arterial, estenosis aórtica con recambio por válvula protésica, y anticoagulada, con escasa adherencia a recomendaciones higiénico dietéticas. Debido a la mala técnica de aplicación de insulina y falta de higiene, desarrolló varias infecciones polimicrobianas de piel y partes blandas, con evolución tórpida de las úlceras y mala respuesta al tratamiento indicado. Durante su internación, de una úlcera se aisló Fusarium oxysporum. Es importante jerarquizar la relevancia de la educación diabetológica en pacientes insulinizados y el rol de los educadores en diabetes en el cuidado de los mismos. Por otro lado, destacar la importancia de la toma de cultivos mediante punción de partes blandas ante la aparición de signos locales de infección.

Abstract Diabetes mellitus (DM) is a very prevalent chronic disease. Among the treatments for DM, insulin is the most potent antidiabetic agent. However a significant proportion of patients fail to achieve Errors in the application of insulin are an important and correctable factor in many cases. We present the case of a patient with DM who, due to poor insulin application technique and hygiene, develops a skin and soft tissue infection with subsequent appearance of Fusarium oxysporum. It is important to emphasize the relevance of diabetes education in insulin ized patients and the role of diabetes educators in their care. On the other hand, it is important to emphasize the importance of taking cultures by soft tissue puncture in case of local signs of infection.

Abstract Welding procedures for repairing corroded tubular structures are commonly used; however, composite material repairs are becoming popular since they do not use heat sources that might cause accidents. This paper provides a detailed description of the CFRP patch repair application in steel tubular members with a circular perforation originated from a prolonged corrosion process. The results of experimental tests on mid-scale unrepaired damaged and repaired steel tubes are reported. The predictions of the maximum loads recovered from a proposed numerical model lie close to the experimental observed values, justifying its usage for analysis of repaired tubular structures with circular cutouts when subjected to axial compression. Compared to unrepaired perforated tubes, the experimental results demonstrate a substantial strength recovery for repaired tubes. The value of this research for the oil and gas industry is that it demonstrates the feasibility of this kind of repair, which means reduced risk to the production unit and a shorter repair period. used however accidents process midscale mid scale reported values compression period

ABSTRACT The study of the interaction between hydraulic structures in mobile bed river systems is complex because it involves sediment transport and dynamic changes in the boundary conditions, requiring the use of physical models. This article presents the procedure for the design and construction of a physical model of the reservoir and dam of the Small Hydroelectric Power Plant (SHPP) of Salto Paraopeba. In the design phase, computational modelling of sediment transport was used to reconstitute the primitive geometry of the river, and simulations of the flow regime and the transport capacity along the course of the river were also carried out; both results allowed to delimit the model extension. Considering the choice of scale and the similarity criteria between the model and the prototype, the use of a new alternative material was proposed, composed of crushed tire rubber particles, with a lower specific mass and a larger diameter than the prototype's sediment. In the construction phase, a new constructive method of the physical model was applied using fiberglass, the method presents constructive advantages, such as better representation of the morphology, lower weight, simple installation and uninstallation through modules, and simple and fast repairs, among others. conditions models SHPP (SHPP Paraopeba phase out extension prototype proposed particles prototypes s fiberglass advantages morphology weight modules repairs others

RESUMO O estudo da interação entre estruturas hidráulicas em sistemas fluviais de leito móvel é complexo pois envolve transporte de sedimentos e mudanças dinâmicas nas condições de contorno, sendo necessário o uso de modelos físicos. Este artigo apresenta o procedimento para o desenho e construção de um modelo físico do reservatório e da barragem da Pequena Central Hidroelétrica (PCH) de Salto Paraopeba. Na fase de desenho, foi utilizada a modelagem computacional de transporte de sedimentos para a reconstituição da geometria primitiva do rio, também foram realizadas simulações do regime do escoamento e da capacidade de transporte ao longo do curso do rio; ambos os resultados permitiram delimitar a extensão do modelo. Considerando a escolha da escala e os critérios de semelhança entre o modelo e o protótipo, foi proposto o uso de um novo material alternativo, composto por partículas de borracha de pneu trituradas, de massa específica menor e diâmetro maior do que o sedimento do protótipo. Na fase de construção, foi aplicado um novo método construtivo do modelo físico empregando fibra de vidro, o método apresenta vantagens construtivas como melhor representação da morfologia, menor peso, instalação e desinstalação simples mediante módulos, e reparações simples e rápidas, entre outras. contorno físicos PCH (PCH Paraopeba rio protótipo alternativo trituradas vidro morfologia peso módulos rápidas outras

Special Article Introduction Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7-165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5-275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p< 0.01). No changes were observed for unrelated donors during the study period. Conclusions Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions. trend timeseries series 200 201 Implants calculated Altogether 8474 8 474 8,47 2 67.5% 675 67 5 67.5%) 30%. 30 30% . (30%) agesex age sex 1533 153 3 153. HSCT10 10 HSCT/1 95% 95 (95 141.7165.8 14171658 141.7 165.8 141 7 165 141.7-165.8 2601 260 1 260. 245.5275.5 24552755 245.5 275.5 245 275 245.5-275.5 regions years group 63 6 6.3 5.47.3 5473 5.4 7.3 4 5.4-7.3 p 0.01. 001 0.01 0 01 0.01) Agesex Age increasing found 20 847 47 8,4 67.5 (30% 15 HSCT1 HSCT/ 9 (9 7165 141.7165. 1417165 1417 141. 1658 165. 14 16 141.7-165. 26 5275 245.5275. 2455275 2455 245. 2755 275. 24 27 245.5-275. 6. 5.47. 547 54 5. 73 7. 5.4-7. 00 0.0 84 8, 67. (30 ( 716 141.7165 141716 141.7-165 527 245.5275 245527 245.5-275 5.47 5.4-7 0. (3 71 141.716 14171 141.7-16 52 245.527 24552 245.5-27 5.4- 141.71 141.7-1 245.52 245.5-2 141.7- 245.5-

Abstract In previous studies carried out in Durango, 115 species of scolitins were reported, the majority in temperate forests, some studies have been carried out near the main roads, since the work published by Wood (1982) to date, only eight species have been added. This work was carried out for a period of one year from december 2019 to November 2020. Ecoiapar traps baited with ethanol were used. The highest specific richness that occurred was eight species in site four, while the lowest corresponded to site two with five species. On the other hand, the highest abundance was from site six with 119 captures, while Monarthrum tuberculatum was the most abundant species during the study. 13 new state records are reported Corthylus burgosi, C. nudus, Hylocurus femineus, Hylurgops longipennis, Monarthrum ca. scutellare, M. dentigerum, M. huachucae, M. tuberculatum, M. xalapensis, Pityophthorus ca. miniatus, P. cacuminatus, P. infulatus, P. virilis, P. granulatus, and one for Mexico Pityophtorus infulatus. The results represent an increase of 12.17% of the known diversity for the state of Durango, compared to the 115 species previously registered, which amounts to a total of 129 species for the state.

Resumen En estudios previos realizados en Durango se han reportado 115 especies de escolitínos, la mayoría en bosques templados cercanos a las carreteras principales. Desde el trabajo publicado por Wood (1982) a la fecha se han agregado solo ocho especies. El presente trabajo se realizó de diciembre de 2019 a noviembre de 2020 utilizando trampas Ecoiapar cebadas con etanol. La mayor riqueza especifica fue de ocho especies en el sitio cuatro, mientras que la menor correspondió al sitio dos con cinco especies. Por otra parte, la mayor abundancia fue en el sitio seis con 119 capturas, siendo Monarthrum tuberculatum la especie más abundante durante el estudio. Se reportan 13 nuevos registros estatales Corthylus burgosi, C. nudus, Hylocurus femineus, Hylurgops longipennis, Monarthrum ca. scutellare, M. dentigerum, M. huachucae, M. tuberculatum, M. xalapensis, Pityophthorus ca. miniatus, P. cacuminatus, P. infulatus, P. virilis, Pseudopityophthorus granulatus, y una para México, Pityophthorus infulatus. Los resultados representan un aumento del 12.17 % de la riqueza conocida para el estado de Durango, respecto a las 115 especies registradas previamente, lo que asciende a un total de 129 especies para el estado.