Abstract The occurrence of seizures is frequent during the neonatal period due to the functional immaturity of the brain.The presence of these seizures may lead to a diagnosis of neonatal epilepsy, which is usually as sociated with structural alterations of the brain during neurodevelopment. Approximately 50% of people with active epilepsy have at least one comorbid medical di sorder, and the existence of a comorbid process changes the course of the epilepsy. The presence of neurologic disorders preceding the onset of epilepsy indicates that underlying neurobiological alterations may indepen dently cause the predisposition to epilepsy and comor bid processes. In this review we describe the structural and functional brain processes underlying the onset of neonatal epilepsy and its comorbidities.

Resumen La aparición de convulsiones es frecuente durante el periodo neonatal debido a las características de inma durez funcional del cerebro es este periodo. La aparición de estas convulsiones puede llevar a un diagnóstico de epilepsia neonatal, que suele estar asociado a alteracio nes estructurales del cerebro durante el neurodesarrollo. Aproximadamente el 50% de las personas con epilepsia activa padecen al menos un trastorno médico comórbi do, y esto hace que cambie la evolución de la epilepsia. La presencia de trastornos neurológicos que preceden a la aparición de la epilepsia indica que alteraciones es tructurales y/o funcionales del cerebro subyacentes pue den ser causa de la predisposición a padecer epilepsia y de los procesos comórbidos de manera independiente. En esta revisión describimos los procesos cerebrales estructurales y funcionales que subyacen a la aparición de epilepsia neonatal y sus comorbilidades.

Abstract In Brazil, 65% of the electric power production comes from hydroelectric power plants (HPPs). In some cases, these power plants divert the course of rivers, resulting in regions impacted by the absence of water, which are known as reduced fow sections (RFS). These sections are regulated by legislation and aim to maintain the minimum fow necessary to preserve the fauna, flora, fish, and human consumption in the region. Depending on the time of year, this minimum flow, also known as ecological flow (residual flow), can reach significant values, resulting in the interruption of power generation in these HPPs. This article presents a study case of two hydroelectric power plants located in different Brazilian states. The objective of this study is to explore the feasibility of implementing auxiliary generator groups that can operate uninterruptedly at different drop heights while ensuring the preservation of residual flow during low flow periods or taking advantage of the overflow flow by spillways during high flow periods. This auxiliary system would use the same set of structures and transmission systems as the main power plant, minimizing environmental impacts and implementation costs, allowing this solution to be implemented in HPPs that face this type of problem in Brazil. The results obtained indicate that HPPs with larger reservoirs have a greater ability to maintain residual flows with minimal generation loss and that run-of-the-river power plants are the most impacted by the maintenance of residual flow. Brazil 65 . (HPPs) cases rivers water RFS. RFS (RFS) fauna flora fish region year , flow) values states plant costs runoftheriver run river 6 (HPPs (RFS

Abstract Background Recently, a new heart failure (HF) classification was made considering the left ventricular ejection fraction (LVEF) phenotype. Comprehensive assessments of the groups are required to guide patient management. Objective To determine the differences in sociodemographic, clinical, functional aerobic capacity, and health-related quality of life (HRQOL) variables in patients with HF classified with different LVEFs and to explore the correlations between the variables. Methods This work is a cross-sectional descriptive and correlational study. Three groups of patients with HF (LVEF≥50%, LVEF<40%, and LVEF40-49%) were compared. Sociodemographic, clinical variables and functional aerobic capacity with Sit to Stand (STS), 6-minute walk test (6MWT), Duke Activity Status Index (DASI), Minnesota Living with HF Questionnaire (MLFHQ), and Patient Health Questionnaire 9 (PHQ-9) were considered. The Chi-square test, one-way analysis of variance (ANOVA) test, and Spearman's correlation were used for statistical analysis. The statistical significance level was set at 5%. Results A total of 209 patients were admitted with a diagnosis of HF, with a more significant number of men. Marital status was a predominantly stable union in the HF with preserved ejection fraction (HFpEF) and HF with mid-range ejection fraction (HFmrEF) groups. A sedentary lifestyle was lower in the HF with reduced ejection fraction (HFrEF) group 59 (84.3%), p-value = 0.033, and the angina pectoris was higher in the HFpEF 30 (42.9%). Systolic blood pressure at the end of the 6MWT evidenced a higher score in HFpEF 132.0±17.25 concerning HFrEF 128.0±16.57, p-value=0.043. The fat percentage was higher in HFpEF 30.20±8.80 regarding the HFmrEF group 26.51±7.60, p-value = 0.028. Conclusion There were significant differences according to the LVEF classification in marital status, angina symptoms, fat percentage, and blood pressure at rest. Recently (HF (LVEF phenotype management sociodemographic healthrelated health related HRQOL (HRQOL crosssectional cross sectional study LVEF≥50%, LVEF50 50 (LVEF≥50% LVEF40 40 LVEF<40% LVEF4049% LVEF4049 49% 49 LVEF40-49% compared Sociodemographic STS, STS , (STS) 6minute minute 6 6MWT, MWT (6MWT) DASI, DASI (DASI) MLFHQ, MLFHQ (MLFHQ) PHQ9 PHQ (PHQ-9 considered Chisquare Chi square oneway one way ANOVA (ANOVA Spearmans Spearman s 5 5% 20 men (HFpEF midrange mid range (HFmrEF (HFrEF 84.3%, 843 84.3% 84 3 (84.3%) pvalue p value 0033 0 033 0.033 42.9%. 429 42.9% . 42 (42.9%) 13201725 132 17 25 132.0±17.2 12801657 128 16 57 128.0±16.57 pvalue=0.043. pvalue0043 value=0.043. 043 p-value=0.043 3020880 8 80 30.20±8.8 2651760 26 51 7 60 26.51±7.60 0028 028 0.028 symptoms rest LVEF≥50% LVEF5 (LVEF≥50 LVEF4 4 LVEF<40 LVEF404 LVEF40-49 (STS (6MWT (DASI (MLFHQ (PHQ- 2 84.3 (84.3% 003 03 0.03 42.9 (42.9% 1320172 13 1 132.0±17. 1280165 12 128.0±16.5 pvalue=0.043 pvalue004 value0043 value=0.043 04 p-value=0.04 302088 30.20±8. 265176 26.51±7.6 002 02 0.02 LVEF≥50 (LVEF≥5 LVEF<4 LVEF40-4 (PHQ 84. (84.3 00 0.0 42. (42.9 132017 132.0±17 128016 128.0±16. pvalue=0.04 pvalue00 value004 value=0.04 p-value=0.0 30208 30.20±8 26517 26.51±7. LVEF≥5 (LVEF≥ LVEF< LVEF40- (84. 0. (42. 13201 132.0±1 12801 128.0±16 pvalue=0.0 pvalue0 value00 value=0.0 p-value=0. 3020 30.20± 2651 26.51±7 LVEF≥ (84 (42 1320 132.0± 1280 128.0±1 pvalue=0. value0 value=0. p-value=0 302 30.20 265 26.51± (8 (4 132.0 128.0± pvalue=0 value=0 p-value= 30.2 26.51 ( 132. 128.0 pvalue= value= 30. 26.5 128. 26.

The graphene oxide (GO)-silver nanoparticles (AgNPs) hybrid material (GO-AgNPs) has garnered significant interest due to its ability to combine the unique properties of GO and AgNPs, showing promise applications in biomedicine, nanocomposites, biosensors, and antimicrobial materials. However, further investigation is needed to understand the nanobio-interactions and toxicity of GO-AgNPs nanohybrid. Assessing the toxicity of GO-AgNPs on red blood cells (hemolysis) and its interactions with blood biomolecules (biocorona formation) is mandatory for biomedical applications and safety evaluation of this material. In this work, we investigate the biocorona formation associated with GO-AgNPs after interaction with human plasma and hemolysate biomolecules linked to its hemolytic effects. Both GO and GO-AgNPs exhibited a dose-dependent hemolytic effect, with GO-AgNPs showing three times greater hemolysis than GO. Nonetheless, biocorona formation fully mitigated the hemolytic effect of both materials, however, morphological damages in red blood cells may occur yet. Our findings show that biocorona formation dramatically changes the surface chemistry, colloidal behavior and toxicity of this hybrid material. Finally, this work contributes to understanding how graphene-silver nanoparticles interact with blood components to design strategies to minimize toxicity risks and enhance their applications in biomedicine and nanobiotechnology. GOsilver silver AgNPs (AgNPs GOAgNPs (GO-AgNPs nanocomposites biosensors materials However nanobiointeractions nanobio nanohybrid (hemolysis effects dosedependent dose dependent Nonetheless however yet chemistry Finally graphenesilver nanobiotechnology

Abstract Many technical propositions have been incorporated to the surgical management of hemorrhoidal disease during the recent decades. Besides that, escisional techniques are still considered the best option to control symptoms and reduce recurrence. The present manuscript aims to propose a technical modification of the classical closed hemorrhoidectomy described by Ferguson in America. Our proposition is to perform two sutures to close the wound resulting from hemorrhoidal resection. The first one consists of an anchored continuous suture using a very thin (4–0 or 5–0) monofilamentar thread coming from inside to the outside skin. After tying the stitch, a simple continuous second suture is made over the previous suture only for mucosal approximation, from outside to inside. Finally, the stich that initiated the first suture is tied up to the stich used for the second suture, and the knot remains located above the dentate line, not to disturb the patient. The confection of two layers aims to reinforce the closing of the wound and avoid dehiscence. The idea is that this modification influences postoperative outcomes by reducing symptoms such as wound discharge and pain, and thus improving healing and esthetics. In a next step research, a comparison with the classical technique may bring new insights to this issue. decades recurrence America resection 4–0 40 4 0 (4– 5–0 50 5 skin stitch approximation Finally line patient dehiscence pain esthetics research issue 4– (4 5– (

RESUMEN Objetivos. i) Determinar las percepciones de las partes interesadas sobre los factores contextuales y los recursos necesarios para implementar con éxito la plataforma AMORE, una herramienta que proporciona evaluaciones de accesibilidad para los servicios de atención de salud, teniendo en cuenta factores como el tiempo de desplazamiento y el estado del tráfico; y ii) determinar los posibles factores que obstaculizan o favorecen las mejoras en la accesibilidad espacial a los servicios de atención de salud en el contexto urbano en Colombia. Métodos. En este estudio cualitativo, se realizaron entrevistas semiestructuradas en una muestra intencional de siete partes interesadas. La muestra se obtuvo a partir de responsables del diseño de políticas en Colombia, prestadores de servicios y usuarios, entre otras personas, con conocimientos en la materia. Las entrevistas se llevaron a cabo hasta llegar al punto de saturación. Resultados. Los participantes tenían una opinión favorable sobre el aspecto de la plataforma AMORE, de la que resaltaban su fácil visualización. Se formularon sugerencias sobre las variables utilizadas en el panel de información, la implementación de la plataforma, las posibles áreas de uso y los elementos que podrían obstaculizar o favorecer su implementación y uso. Los obstáculos incluían desafíos económicos, políticos y de personal, mientras que entre los elementos facilitadores estaban la creación de un producto mínimo viable a bajo costo y el establecimiento de lazos de cooperación interinstitucional e internacional. Conclusiones. Innovaciones como la plataforma AMORE tienen el potencial de brindar apoyo para los procesos de toma de decisiones en diversos sectores, como las políticas públicas y los procesos internos en las organizaciones privadas, el sector académico y la comunidad. Sin embargo, la implementación de una herramienta de este tipo plantea desafíos económicos, contextuales y ambientales. El estudio determinó los factores clave que se consideran requisitos previos para implementar con éxito la plataforma AMORE en las ciudades colombianas.

ABSTRACT Objectives. To (i) ascertain stakeholders’ perceptions of the contextual factors and resources necessary to successfully implement the AMORE platform, a tool that provides accessibility assessments for health care services, considering factors such travel time and traffic conditions, and (ii) identify potential barriers to and facilitators for enhancing spatial accessibility to health care services within the Colombian urban context. Methods. In this qualitative study, semi-structured interviews were conducted with a purposive sample of seven key stakeholders. The sample was drawn from individuals involved in development of policies in Colombia, service providers, and users, among others, who had expertise in the field. Interviews were conducted until saturation was reached. Results. The participants had positive views on the appearance of the AMORE platform, highlighting its user-friendly visualization. Suggestions were made about the variables used in the dashboard, the implementation of the platform, potential usage areas, and barriers and facilitators to implementation and use. Barriers included economic, political, and personnel challenges, while facilitators included creating a minimum viable product at a low cost and building interinstitutional and international cooperation. Conclusions. Innovations such as the AMORE platform have the potential to support decision-making processes across various sectors, including public policies and internal processes within private organizations, academia, and the community. However, implementing such a tool has financial, contextual and environmental challenges. The study identified key factors that were considered prerequisites for successfully implementing the AMORE platform in Colombian cities.

RESUMO Objetivos. Os objetivos do estudo foram: i) avaliar as percepções das partes interessadas sobre os fatores contextuais e os recursos necessários para implementação bem-sucedida da plataforma AMORE, uma ferramenta que fornece avaliações sobre a acessibilidade dos serviços de saúde considerando fatores como tempo de deslocamento e condições de trânsito; e ii) identificar possíveis barreiras e facilitadores para melhorar a acessibilidade espacial a serviços de saúde no contexto urbano da Colômbia. Métodos. Neste estudo qualitativo, foram realizadas entrevistas semiestruturadas com uma amostra intencional de sete partes interessadas principais. A amostra foi composta por indivíduos envolvidos na elaboração de políticas na Colômbia, prestadores de serviços e usuários, entre outros, que tinham conhecimento especializado na área. As entrevistas foram realizadas até se alcançar a saturação. Resultados. Os participantes tiveram opiniões positivas sobre a aparência da plataforma AMORE, destacando a visualização fácil de usar. Foram feitas sugestões sobre as variáveis usadas no painel, a implementação da plataforma, potenciais áreas de uso e barreiras e facilitadores para sua implementação e utilização. As barreiras englobavam dificuldades econômicas, políticas e relacionadas ao pessoal. Já os facilitadores incluíam a criação de um produto mínimo viável de baixo custo e o desenvolvimento de cooperação interinstitucional e internacional. Conclusões. Inovações como a plataforma AMORE têm o potencial de apoiar processos decisórios em vários setores, incluindo políticas públicas e processos internos em organizações privadas, no meio acadêmico e na comunidade. No entanto, a implementação dessa ferramenta envolve desafios financeiros, contextuais e ambientais. O estudo identificou os principais fatores que foram considerados pré-requisitos para o sucesso da implementação da plataforma AMORE em cidades colombianas.

BACKGROUND: Veterinary medicine has seen significant advancements in locoregional anaesthesia and pain management, including the emergence of the erector spinae plane (ESP) block. However, limited clinical evidence exists on its efficacy and safety OBJECTIVES: This study compares ultrasound-guided ESP block (ESP group) with an intraoperative intravenous ketamine infusion analgesic protocol (CRI group) in dogs undergoing thoracolumbar mini-hemilaminectomy, focusing on intraoperative opioid consumption, cardiovascular response to surgical stimulation (CR), postoperative pain scores (PS), and postoperative opioid consumption METHODS: Retrospective, case-control, non-inferiority study conducted in a single centre. Data collected included demographics, bupivacaine dose, ESP block operator, intraoperative recorded variables (haemodynamic variables, CR, complications, rescue analgesia), pre- and postoperative analgesia, 24-hour PS and opioid administration, first food intake post-extubation and postoperative complications. Univariate and multiple regression analyses were applied RESULTS: One-hundred dogs were included, 75 in the ESP group and 25 in the CRI group. Univariate analysis revealed no significant differences between treatment groups in terms of CR, PS, postoperative rescue analgesia, intraoperative and postoperative opioid consumption, or time to first meal intake. However, the multivariate regression analysis indicated that dogs receiving ketamine infusion had higher CR suspected to be nociception-related (p = 0.036), and higher postoperative opioid consumption (p = 0.013 CONCLUSION: Our study suggests that ultrasound-guided ESP block is as effective as intraoperative ketamine infusion providing perioperative analgesia in dogs undergoing thoracolumbar mini-hemilaminectomy for intervertebral disc disease. ESP group showed significantly lower CR suspected to be nociception-related intraoperatively and lower postoperative opioid consumption within the initial 24 hours

Resumen Introducción. Spodoptera frugiperda tiene la capacidad de formar grandes poblaciones y su alta tasa de diseminación, convierten a esta especie en una plaga de impacto económico. Las pérdidas debido a plagas y enfermedades se estiman en un 37 % de la producción agrícola mundial, con un 13 % a causa de los insectos. Objetivo. Evaluar el ataque, establecimiento y dinámica poblacional de orugas de cogollero en líneas de maíz. Materiales y métodos. El estudio se realizó en laboratorio del Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias y en el Instituto Tecnológico de Roque, ubicado en Celaya, Guanajuato, en 2019. Se estableció la siembra manual y cuando las plántulas alcanzaron V4, a los veinticinco días después de la siembra, se infestaron con larvas estadio IV. Para medir la dinámica poblacional, se realizaron muestreos a partir del día veintiséis, lo que cubrió todo el ciclo biológico (huevecillos, larva I, larva II, larva III, larva IV, larva V, pupa y adulto). Se empleó un diseño experimental completamente al azar con diez genotipos y diez repeticiones. Resultados. Los estadios de S. frugiperda que generaron mayor variabilidad en las líneas de maíz fueron larvas IV y V. La dinámica poblacional mostró diferencias entre genotipos tolerantes con una población acumulada de cuatro a siete orugas en estadio IV y V, mientras que los susceptibles presentaron siete a veintiuna larvas IV y catorce a veintiuna larvas estadio V. Las líneas sobresalientes de maíz presentaron un acumulado de dos a seis larvas IV y cuatro a cinco orugas en estadio V por planta. Conclusión. La variabilidad fue mayor en los estadios larvarios IV y V de Spodoptera frugiperda, que sucedió entre los 26 y 54 días después de la siembra. En los genotipos tolerantes de maíz se encontraron hasta siete larvas por planta, mientras que en los susceptibles presentaron veintiún orugas.

Abstract Introduction. Spodoptera frugiperda has the ability to form large populations, and its high dissemination rate makes this species an economically impactful pest. Losses due to pests and diseases are estimated at 37 % of global agricultural production, with 13 % caused by insects. Objective. To evaluate the attack, establishment, and population dynamics of fall armyworm larvae in maize lines. Materials and methods. The study was carried out in the laboratories of the Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias and the Instituto Tecnológico de Roque, located in Celaya, Guanajuato, in 2019. Manual sowing was performed, and when the seedlings reached V4 stage, twenty-five days after sowing, they were infested with IV instar larvae. Population dynamics were measured starting from day twenty-six, covering the entire biological cycle (eggs, larva I, larva II, larva III, larva IV, larva V, pupa, and adult). A completely randomized experimental design with ten genotypes and ten replicates was employed. Results. S. frugiperda instar stages that showed the highest variability in maize lines were larvae IV and V. The population dynamics exhibited differences among tolerant genotypes, with an accumulated population of four to seven larvae in stages IV and V, while susceptible genotypes showed seven to twenty-one larvae in stage IV and fourteen to twenty-one in stage V. The outstanding maize presented an accumulation of two to six larvae in stage IV and four to five in stage per plant. Conclusion. The highest variability was observed in S. frugiperda larval stages IV and V, occurring between 26 and 54 days after planting. In the tolerant maize genotypes up to seven larvae were found per plant, while the susceptible ones showed twenty-one caterpillars.

Resumo As proporções de areia nas argamassas de tipo II foram analisadas de acordo com a norma N-CMT-2-01-004/02. Foram utilizados três tipos de agregados da região de Morelia, Michoacán para determinar a sua influência nas suas propriedades físico-mecânicas. Considerando a utilização de diferentes materiais cimentícios (CM): cimento Portland mais cimento de alvenaria (B2) e cimento Portland mais cal (B1). Foram preparadas misturas para B1 e B2 com relações areia/MC de 2,25 para 4. Foram determinadas a fluidez, resistência uniaxial à compressão (UCS) e resistividade elétrica úmida (WER). Estudando a relação entre a fluidez e a quantidade de água/MC, concluindo que o tipo de agregado e as proporções modificam a fluidez e a demanda de água no estado fresco com impacto no UCS e no WER.

Abstract The influence of the sand proportion in mortars Type II was studied, according to the standard N-CMT-2-01-004/02, using three fine aggregates from the region of Morelia, in Michoacan, and determining their influence in the physico-mechanical properties, while considering the use of different cementitious materials (CM): Portland cement plus lime (B1), and Portland cement plus construction cement (B2). Mortar mixtures were designed for B1 and B2 with volume ratios of aggregates/CM, from 2.25 to 4, determining the fluency, the uniaxial compressive strength (UCS) and the wet electrical resistivity (WER). The relation between the fluency and the ratio water/CM were studied, concluding that the aggregate type and the proportions employed modify the fluency and the water demand in the fresh state of the mortar, and consequently impact the UCS and WER.

Resumen Se analizó la influencia de la proporción de arena en morteros Tipo II según norma N-CMT-2-01-004/02 empleando tres tipos de áridos de la región de Morelia, Michoacán determinando su influencia en sus propiedades físico-mecánicas, contemplando el uso de diferentes materiales cementantes (MC): el cemento Portland más cal (B1), cemento Portland más cemento de albañilería (B2). Se elaboraron mezclas para B1 y B2 con relaciones en volumen arena/MC, desde 2.25 hasta 4, determinando la fluidez, resistencia a compresión uniaxial (UCS) y resistividad eléctrica húmeda (WER). Se estudió la relación entre la fluidez y la cantidad de agua/MC, concluyendo que el tipo de árido y proporciones modifican la fluidez y demanda de agua en estado fresco impactando en UCS y WER.

Abstract Microstructure, texture, and mechanical and fracture characterization of three insulating commercial refractories were carried out in order to establish a correlation between these properties. The materials were characterized using X-ray powder diffraction (XRD) with Rietveld and Le Bail approximation to perform phase quantification, mercury intrusion porosimetry, and scanning electron microscopy. The mechanical behavior of insulating commercial refractories was studied with a multi-technique approach that involved a three-point bending test, uniaxial compression test, and single-edge notched beam (SENB) test. Stable fracture tests were successfully performed. The obtained results showed that the main differences between the materials studied were pore size distribution and mineralogical composition. Materials with the major amount of mullite had the highest values of the mechanical parameters in the different performed tests. Microstructure texture properties Xray X ray XRD (XRD quantification porosimetry microscopy multitechnique multi technique threepoint point test singleedge single edge SENB (SENB composition

Resumen En este trabajo se elaboraron películas comestibles (PCs) a base de quitosano (Q), agar (A) y tomillo (T), en cuatro diferentes formulaciones (Q, A, QA y QAT). A las PCs se les evaluaron propiedades mecánicas (tensión y elongación a la ruptura), propiedades estructurales (espectroscopía de infrarrojo por FTIR), propiedades térmicas (análisis termogravimétrico), propiedades de transporte (permeabilidad al vapor de agua) y análisis morfológico (microscopía electrónica de barrido). Las PCs de QA y QAT destacaron por su resistencia a la tensión, transparencia, velocidad de transmisión al vapor de agua y permeancia, así como la mayor capacidad antio-xidante. Se evaluó el efecto de la aplicación de los recubrimientos comestibles (RCs) de QA y QAT en la calidad de frutos de aguacate “Hass” durante 13 días de almacenamiento a 25 °C. Se evaluaron periódicamente en los frutos las variables de pérdida de peso, tasa de respiración, producción de etileno, apariencia visual y pudriciones. La aplicación de los RCs al fruto redujo su pérdida de peso y extendió su vida de anaquel. Los RCs les confirieron a los frutos una barrera al vapor de agua, reduciendo la pérdida de peso en 40%. Así mismo, se disminuyó la incidencia de pudriciones de los frutos.

Abstract In this work, edible films (PCs) based on chitosan (Q), agar (A) and thyme oil (T) were prepared in four different formulations (Q, A, QA and QAT), and their mechanical properties (tension and elongation at break) and water vapor permeability were evaluated. Infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) were also performed. The QA and QAT PCs stood out for their tensile strength, transparency, water vapor transmission rate and permeance, as well as the highest antioxidant activity. The effect of the application of the edible coatings (RCs) of QA and QAT on the quality of ‘Hass’ avocado fruit was evaluated during 13 d of storage at 25 °C. The following variables were evaluated periodically: weight loss, respiration rate, ethylene production, visual appearance, and rotting. The application of RCs to the fruit reduced their weight loss and extended their shelf life. The RCs gave the fruit a barrier to water vapor, reducing weight loss by 40 with respect to the control. In addition, the incidence of fruit rots was reduced.

Abstract Hereditary transthyretin amyloidosis with peripheral neuropathy (ATTRv-PN) is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy with over 130 pathogenic variants identified in the TTR gene. Hereditary transthyretin amyloidosis with peripheral neuropathy is a disabling, progressive and life-threatening genetic condition that leads to death in ~ 10 years if untreated. The prospects for ATTRv-PN have changed in the last decades, as it has become a treatable neuropathy. In addition to liver transplantation, initiated in 1990, there are now at least 3 drugs approved in many countries, including Brazil, and many more are being developed. The first Brazilian consensus on ATTRv-PN was held in the city of Fortaleza, Brazil, in June 2017. Given the new advances in the area over the last 5 years, the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology organized a second edition of the consensus. Each panelist was responsible for reviewing the literature and updating a section of the previous paper. Thereafter, the 18 panelists got together virtually after careful review of the draft, discussed each section of the text, and reached a consensus for the final version of the manuscript. ATTRvPN ATTRv PN (ATTRv-PN 13 gene disabling lifethreatening life threatening 1 untreated decades transplantation 1990 countries Brazil developed Fortaleza 2017 paper Thereafter draft text manuscript 199 201 19 20 2

Resumo Polineuropatia amiloidótica familiar associada a transtirretina (ATTRv-PN) é uma polineuropatia sensitivo-motora e autonômica hereditária autossômica dominante com mais de 130 variantes patogênicas já identificadas no gene TTR. A ATTRv-PN é uma condição genética debilitante, progressiva e que ameaça a vida, levando à morte em ~ 10 anos se não for tratada. Nas últimas décadas, a ATTRv-PN se tornou uma neuropatia tratável. Além do transplante de fígado, iniciado em 1990, temos agora 3 medicamentos modificadores de doença aprovados em muitos países, incluindo o Brasil, e muitas outras medicações estão em desenvolvimento. O primeiro consenso brasileiro em ATTRv-PN foi realizado em Fortaleza em junho de 2017. Devido aos novos avanços nesta área nos últimos 5 anos, o Departamento Científico de Neuropatias Periféricas da Academia Brasileira de Neurologia organizou uma segunda edição do consenso. Cada panelista ficou responsável por rever a literatura e atualizar uma parte do manuscrito. Finalmente, os 18 panelistas se reuniram virtualmente após revisão da primeira versão, discutiram cada parte do artigo e chegaram a um consenso sobre a versão final do manuscrito. ATTRvPN ATTRv PN (ATTRv-PN sensitivomotora sensitivo motora 13 TTR debilitante vida 1 tratada décadas tratável fígado 1990 países Brasil desenvolvimento 2017 manuscrito Finalmente 199 201 19 20 2

Abstract Welding procedures for repairing corroded tubular structures are commonly used; however, composite material repairs are becoming popular since they do not use heat sources that might cause accidents. This paper provides a detailed description of the CFRP patch repair application in steel tubular members with a circular perforation originated from a prolonged corrosion process. The results of experimental tests on mid-scale unrepaired damaged and repaired steel tubes are reported. The predictions of the maximum loads recovered from a proposed numerical model lie close to the experimental observed values, justifying its usage for analysis of repaired tubular structures with circular cutouts when subjected to axial compression. Compared to unrepaired perforated tubes, the experimental results demonstrate a substantial strength recovery for repaired tubes. The value of this research for the oil and gas industry is that it demonstrates the feasibility of this kind of repair, which means reduced risk to the production unit and a shorter repair period. used however accidents process midscale mid scale reported values compression period

Abstract Dental hard tissue conditions can be of pre- or post-eruptive nature, such as enamel fluorosis and erosive tooth wear (ETW), respectively. Dental enamel fluorosis is caused by the chronic and excessive intake of fluoride during enamel development, leading to increased fluoride concentration and increased porosity. ETW has become a common clinical condition and often impairs dental function and aesthetics. This in vitro study tested the hypothesis that fluorotic enamel presents different susceptibility to dental erosion-abrasion. It consisted of a 3×3×2 factorial design, considering a) fluorosis severity: sound (TF0), mild (TF1-2), moderate (TF3-4); b) abrasive challenge: low, medium, and high; and c) erosive challenge: yes or no. A total of 144 human teeth were selected according to the three fluorosis severity levels (n=48), and subdivided into six groups (n = 8) generated by the association of the different erosive and abrasive challenges. Enamel blocks (4×4 mm) were prepared from each tooth and their natural enamel surfaces subjected to an erosion-abrasion cycling model. After cycling, the depth of the lesions in enamel was assessed by profilometry. ANOVA showed that the three-way and two-way interactions among the factors were not significant (p > 0.20). Enamel fluorosis level (p=0.638) and abrasion level (p = 0.390) had no significant effect on lesion depth. Acid exposure caused significantly more enamel surface loss than water (p < 0.001). Considering the limitations of this in vitro study, fluorosis did not affect the susceptibility of enamel to dental erosion-abrasion. pre posteruptive post eruptive nature ETW, , (ETW) respectively development porosity aesthetics erosionabrasion. erosionabrasion erosion abrasion. 332 3 2 3×3× design TF0, TF0 TF (TF0) TF12, TF12 TF1 (TF1-2) TF34 TF3 4 (TF3-4) b challenge low medium high c 14 n=48, n48 n n=48 48 (n=48) 8 challenges 4×4 44 (4× mm model profilometry threeway way twoway two p 0.20. 020 0.20 . 0 20 0.20) p=0.638 p0638 638 (p=0.638 0.390 0390 390 0.001. 0001 0.001 001 0.001) (ETW 33 3×3 (TF0 (TF1-2 (TF3-4 1 n4 n=4 (n=48 4× (4 02 0.2 p=0.63 p063 63 (p=0.63 0.39 039 39 000 0.00 00 3× (TF (TF1- (TF3- n= (n=4 ( 0. p=0.6 p06 6 (p=0.6 0.3 03 0.0 (TF1 (TF3 (n= p=0. p0 (p=0. p=0 (p=0 p= (p=