Abstract The aim was to map evidence on the quality of records in the Mortality Information System (SIM) through a national scoping review of articles published up to April 2023 across five databases (PubMed, Embase, Scopus, LILACS, and SciELO). Studies focused on specific causes of death were excluded. Dimensions evaluated included accessibility, methodological clarity, coverage, completeness, reliability, consistency, non-duplication, timeliness, validity, and studies on ill-defined causes/garbage codes. Among the 33 included articles, a general improvement in SIM quality was observed, with a 68.5% reduction in garbage codes (2000-2015). However, regional inequalities in SIM persist, with coverage below 90% in Acre and Maranhão and poorer performance in the North and Northeast regions. A robust SIM is essential for public health strategies aimed at preventing avoidable deaths.

Resumo O objetivo foi mapear evidências sobre a qualidade dos registros do Sistema de Informação sobre Mortalidade (SIM) por meio de revisão de escopo nacional com artigos publicados até abril de 2023 em cinco bases (PubMed, Embase, scopus, LILACS e SciELO). Excluíram-se estudos focados em causas específicas de óbito. Foram avaliadas dimensões como acessibilidade, clareza metodologica, cobertura, completitude, confiabilidade, consistencia, nao-duplicidade, oportunidade, validade e estudos de causas mal definidas/garbage codes.. Dos 33 artigos incluídos, observou-se melhoria geral da qualidade do SIM, com redução de 68,5% nos garbage codes (2000-2015). Contudo, persistem desigualdades regionais no SIM, com cobertura abaixo de 90% no Acre e Maranhão e pior desempenho nas regiões Norte e Nordeste. Um SIM robusto é essencial para estratégias de saúde pública voltadas à prevenção de mortes evitáveis.

Resumen El objetivo fue mapear evidencias sobre la calidad de los registros del Sistema de Información sobre Mortalidad (SIM) a través de una revisión de alcance nacional con artículos publicados hasta abril de 2023 en cinco bases de datos (PubMed, Embase, Scopus, LILACS y SciELO). Se excluyeron estudios centrados en causas específicas de muerte. Se evaluaron dimensiones como accesibilidad, claridad metodológica, cobertura, completitud, fiabilidad, consistencia, no duplicación, oportunidad, validez y estudios sobre causas mal definidas/códigos basura. Entre los 33 artículos incluidos, se observó una mejora general en la calidad del SIM, con una reducción del 68,5% en los códigos basura (2000-2015). Sin embargo, persisten desigualdades regionales en el SIM, con una cobertura inferior al 90% en Acre y Maranhão y un peor desempeño en las regiones Norte y Nordeste. Un SIM robusto es esencial para estrategias de salud pública dirigidas a prevenir muertes evitables.

Resumo O objetivo foi mapear evidências sobre a qualidade dos registros do Sistema de Informação sobre Mortalidade (SIM) por meio de revisão de escopo nacional com artigos publicados até abril de 2023 em cinco bases (PubMed, Embase, scopus, LILACS e SciELO). Excluíram-se estudos focados em causas específicas de óbito. Foram avaliadas dimensões como acessibilidade, clareza metodologica, cobertura, completitude, confiabilidade, consistencia, nao-duplicidade, oportunidade, validade e estudos de causas mal definidas/garbage codes.. Dos 33 artigos incluídos, observou-se melhoria geral da qualidade do SIM, com redução de 68,5% nos garbage codes (2000-2015). Contudo, persistem desigualdades regionais no SIM, com cobertura abaixo de 90% no Acre e Maranhão e pior desempenho nas regiões Norte e Nordeste. Um SIM robusto é essencial para estratégias de saúde pública voltadas à prevenção de mortes evitáveis.

Resumen El objetivo fue mapear evidencias sobre la calidad de los registros del Sistema de Información sobre Mortalidad (SIM) a través de una revisión de alcance nacional con artículos publicados hasta abril de 2023 en cinco bases de datos (PubMed, Embase, Scopus, LILACS y SciELO). Se excluyeron estudios centrados en causas específicas de muerte. Se evaluaron dimensiones como accesibilidad, claridad metodológica, cobertura, completitud, fiabilidad, consistencia, no duplicación, oportunidad, validez y estudios sobre causas mal definidas/códigos basura. Entre los 33 artículos incluidos, se observó una mejora general en la calidad del SIM, con una reducción del 68,5% en los códigos basura (2000-2015). Sin embargo, persisten desigualdades regionales en el SIM, con una cobertura inferior al 90% en Acre y Maranhão y un peor desempeño en las regiones Norte y Nordeste. Un SIM robusto es esencial para estrategias de salud pública dirigidas a prevenir muertes evitables.

Abstract The aim was to map evidence on the quality of records in the Mortality Information System (SIM) through a national scoping review of articles published up to April 2023 across five databases (PubMed, Embase, Scopus, LILACS, and SciELO). Studies focused on specific causes of death were excluded. Dimensions evaluated included accessibility, methodological clarity, coverage, completeness, reliability, consistency, non-duplication, timeliness, validity, and studies on ill-defined causes/garbage codes. Among the 33 included articles, a general improvement in SIM quality was observed, with a 68.5% reduction in garbage codes (2000-2015). However, regional inequalities in SIM persist, with coverage below 90% in Acre and Maranhão and poorer performance in the North and Northeast regions. A robust SIM is essential for public health strategies aimed at preventing avoidable deaths.

Lantana caatingensis Moldenke (Verbenaceae) is an endemic plant from northeastern Brazil. However, its chemical composition is almost unknown. This study aimed to characterize the chemical compounds found in L. caatingensis and investigate the antileishmanial potential of its hydroalcoholic extract and polar fractions. Compounds present in the hydroalcoholic extract obtained from L. caatingensis leaves and its polar fractions (ethyl acetate and methanolic) were analyzed by liquid chromatography with a photodiode-array detector coupled to electrospray ionization quadrupole time-of-flight mass spectrometry. An antileishmanial assay was performed in a 96-well plate against Leishmania major promastigotes using resazurin on a plate spectrophotometer and the results were expressed as percentage of growth inhibition. Nine compounds were determined in the investigated extract and fractions, classified as flavonoids, flavonoid C-glycosides and phenylethanoid glycosides. The antileishmanial activity revealed that the hydroalcoholic extract and the ethyl acetate fraction were active against L. major promastigotes with inhibitory concentration of 71.78 and 26.86 µg mL-1, respectively, while the methanolic fraction was inactive (478.40 µg mL-1). This is the first report on the chemical composition and antileishmanial activity of L. caatingensis extracts. These results contribute to further knowledge of species belonging to the Lantana genus. Verbenaceae (Verbenaceae Brazil However unknown L photodiodearray photodiode array timeofflight time flight spectrometry 96well well 96 inhibition flavonoids Cglycosides C glycosides 7178 71 78 71.7 2686 26 86 26.8 mL1, mL1 mL 1, 1 mL-1 respectively 478.40 47840 478 40 (478.4 mL1. . mL-1) extracts genus 9 717 7 71. 268 2 8 26. mL- 478.4 4784 47 4 (478. 478. (478 (47 (4 (

Abstract In Brazil, collaborative support networks have been structured to conduct the process of recognition of Geographical Indication (GI) together with the National Institute of Industrial Property. The objective of the present work was to outline a literature review on the implementation process and governance of GIs in the country for a better understanding of this scenario. The methodology was based on research in the journals of the Higher Education Personnel Improvement Commission and free databases such as Google Scholar, with inclusion and exclusion criteria for selecting publications. Of the 109 publications found, 22 were carefully selected for analysis from the perspective of the dynamics of GI implementation and governance processes in Brazil. It was observed that the collaborative networks to conduct the GI implementation and governance processes were structured with different dynamics in each territory, resulting from efforts and coordination carried out by different Brazilian institutions.

Resumo No Brasil, redes de apoio colaborativas têm sido estruturadas para conduzir o processo de reconhecimento de Indicação Geográfica (IG), junto ao Instituto Nacional de Propriedade Industrial. O objetivo do presente trabalho foi delinear uma revisão de literatura sobre o processo de implementação e a governança da IG no país para melhor compreensão deste cenário. A metodologia foi baseada em pesquisas nos periódicos da Comissão de Aperfeiçoamento de Pessoal do Nível Superior e em bases de dados gratuitas como Google Acadêmico, com critérios de inclusão e exclusão para seleção das publicações. Das 109 publicações encontradas, 22 foram criteriosamente selecionadas para análise sob a ótica da dinâmica dos processos de implementação e governança de IG no Brasil. Observou-se que as redes colaborativas para condução dos processos de implementação e governança de IG foram estruturadas com dinâmicas diferentes em cada território, resultado de esforços e articulações realizadas por diferentes instituições brasileiras.

Resumen En Brasil, se han estructurado redes de apoyo colaborativo para realizar el proceso de reconocimiento de la Indicación Geográfica (IG), junto con el Instituto Nacional de Propiedad Industrial. El objetivo del presente trabajo fue esbozar una revisión bibliográfica sobre el proceso de implementación y gobernanza de las IG en el país para una mejor comprensión de este escenario. La metodología se basó en investigaciones en las revistas de la Comisión de Mejoramiento del Personal de Educación Superior y en bases de datos gratuitas como Google Scholar, con criterios de inclusión y exclusión para la selección de publicaciones. De las 109 publicaciones encontradas, 22 fueron cuidadosamente seleccionadas para el análisis desde la perspectiva de la dinámica de los procesos de implementación y gobernanza de las IG en Brasil. Se observó que las redes colaborativas para conducir los procesos de implementación y gobernanza de la IG se estructuraron con dinámicas diferentes en cada territorio, resultado de esfuerzos y articulaciones realizadas por diferentes instituciones brasileñas.

ABSTRACT OBJECTIVE The transgender population in Brazil faces marginalization and difficulties in accessing education and health, leading many individuals to self-medicate. This study aimed to evaluate the impact of the implementation of Specialized Centers in the Transsexualizing Process (SCTP) on the use of cross-sex hormone therapy (CSHT) without medical prescription, as well as the level of education and mental health profile of these individuals. METHODS This is a cross-sectional study with data from physical and electronic medical records between September 2017 and February 2023 regarding the use of CSHT before and after the implementation of two SCTP in the state of Bahia, Brazil, in addition to data on education level, previous diagnosis of anxiety and depression of patients. RESULTS A total of 219 participants, 127 transgender men (TM) and 92 transgender women and travestis (TrTW), were assessed. A significant reduction in the prevalence of self-medication was observed in both TrTW (92.98% before and 51.43% after, p<0.001), and TM (47.17% before and 25.67% after, p = 0.010) with the implementation of SCTP. Transgender individuals who used CSHT before accessing the service were found to have a lower prevalence of depression. Self-medication was not significantly associated with education or anxiety in our sample. CONCLUSION The results indicate the need for the expansion of SCTP, as they were associated with lower rates of self-medication in the transgender population.

ABSTRACT High-sugar dehydrated foods have strong hygroscopicity, which can be avoided by using drying aids. One way to assess the hygroscopic behavior is through sorption isotherms. The objective of this work was to evaluate the influence of maltodextrin concentration on sorption isotherms of powdered cajá-manga pulp in spray-dryer, lyophilization and fluidized bed spray drying processes. The dryings were carried out in a spray-dryer, lyophilizer and fluidized bed, with 10%, 20% and 30% of maltodextrin. Adsorption isotherms were determined by the static gravimetric method using salt solutions for a relative humidity range of 21% to 90%. The GAB, BET, Henderson, and Oswin models were adequate to the experimental data. The relative deviation between the experimental values and the estimated values was calculated for each curve, in order to assess which equation best fit the experimental data. The mean relative error value of less than 10% was considered one of the criteria for selecting the models. The BET (A), BET (B) and GAB (C) models had the lowest error means, 3.35%, 3.35% and 5.28%, for cajá-manga powders obtained by spray-dryer, lyophilization and fluidized bed spray drying processes, respectively, and coefficients of determination above 0.99. It is concluded that the type of drying process did not influence the behavior of the adsorption isotherms, and that increases in maltodextrin concentration and temperature are significant in reducing equilibrium moisture contents. Highsugar High sugar hygroscopicity aids cajámanga cajá manga spraydryer, spraydryer dryer, dryer spray-dryer processes 10 20 30 21 90 90% Henderson data curve A, A , (A) B (B C (C means 335 3 35 3.35 528 5 28 5.28% respectively 099 0 99 0.99 contents 1 2 9 (A 33 3.3 52 5.28 09 0.9 3. 5.2 0. 5.

SUMMARY OBJECTIVE: The aim of this study was to estimate the prevalence of influenza immunization in elderly people in Brazil in 2019. METHODS: This is a population-based cross-sectional study. The Brazilian individuals (≥60 years) who participated in the 2019 National Health Survey were included. The survey was conducted in permanent households in Brazil from August 2019 to March 2020. The prevalences of influenza vaccination and their respective confidence intervals (95%CI) were estimated according to sociodemographic characteristics and the diagnosis of chronic diseases. RESULTS: The prevalence of influenza vaccination was 72.4% (95%CI 71.5–73.2), with statistically significant differences observed between genders (p=0.001), age groups (p=0.001), and those living with a spouse/partner (p=0.002). Significant differences were found in groups with arterial hypertension (75.2%, p<0.001), diabetes (77.2%, p<0.001), and arthritis or rheumatism (75.5%, p<0.001). CONCLUSION: A global prevalence of influenza vaccination of 72.4% was estimated among elderly people in Brazil. OBJECTIVE METHODS populationbased population based crosssectional cross sectional ≥60 60 (≥6 years 201 included 2020 95%CI 95CI CI 95 diseases RESULTS 724 72 4 72.4 71.5–73.2, 715732 71.5–73.2 , 71 5 73 2 71.5–73.2) p=0.001, p0001 p p=0.001 0 001 (p=0.001) spousepartner spouse partner p=0.002. p0002 p=0.002 . 002 (p=0.002) 75.2%, 752 75 (75.2% p<0.001, p<0.001 p<0.001) 77.2%, 772 77 (77.2% 75.5%, 755 (75.5% p<0.001. CONCLUSION ≥6 6 (≥ 20 202 9 7 72. 71573 71.5–73. p000 p=0.00 00 (p=0.001 (p=0.002 75.2% (75.2 p<0.00 77.2% (77.2 75.5% (75.5 ≥ ( 7157 71.5–73 p00 p=0.0 (p=0.00 75.2 (75. p<0.0 77.2 (77. 75.5 715 71.5–7 p0 p=0. (p=0.0 75. (75 p<0. 77. (77 71.5– p=0 (p=0. (7 p<0 71.5 p= (p=0 p< 71. (p= (p

RESUMO JUSTIFICATIVA E OBJETIVOS: A dor pélvica crônica (DPC) é uma condição comum em mulheres e frequentemente há comorbidades associadas. O objetivo deste estudo foi avaliar a prevalência de comorbidades em pacientes de DPC e buscar associações entre comorbidades e as manifestações da dor crônica. MÉTODOS: Estudo observacional de caso-controle com informações sociodemográficas, comportamentais e clínicas, incluindo comorbidades, em 246 mulheres, sendo 123 com DPC e 123 sem DPC (grupo controle). RESULTADOS: Ansiedade, depressão, enxaqueca e endometriose foram as comorbidades mais frequentes em mulheres com DPC. As comorbidades avaliadas no grupo com DPC não se associaram com o escore de intensidade da dor, com história de aborto, de violência física nem de violência sexual (p>0,05). No grupo de mulheres com DPC e endometriose, a mediana do escore de ansiedade e de depressão foi significativamente menor do que no grupo sem endometriose (14,5; IC 95%: 11,0-14,9) versus (17,0; IC 95%: 14,6-16,7), p=0,012 e (13,0; IC 95%: 11,1-15,9) versus (16,5; IC 95%: 14,5-17,6), p=0,045, respectivamente. Em pacientes com enxaqueca, a mediana do escore de depressão foi maior no grupo de mulheres com DPC em relação ao grupo sem DPC (15,0; IC 95%: 14,1-17,8) versus (10,0; IC 95%: 8,5-12,4), p=0,048. CONCLUSÃO: As comorbidades mais prevalentes em mulheres com DPC foram transtornos mentais, enxaqueca e endometriose. As comorbidades não se associaram à intensidade da dor, violência física ou sexual. O diagnóstico de endometriose associou-se a menores escores de ansiedade e de depressão em mulheres com DPC. A sobreposição de enxaqueca e DPC associou-se a um pior escore de depressão. OBJETIVOS (DPC associadas MÉTODOS casocontrole caso controle sociodemográficas clínicas 24 12 controle. . controle) RESULTADOS Ansiedade aborto p>0,05. p005 p p>0,05 0 05 (p>0,05) 14,5 145 14 5 (14,5 95% 95 11,014,9 110149 11,0 14,9 11 9 11,0-14,9 17,0 170 17 (17,0 14,616,7, 146167 14,6 16,7 , 6 16 7 14,6-16,7) p0012 012 p=0,01 13,0 130 13 (13,0 11,115,9 111159 11,1 15,9 1 15 11,1-15,9 16,5 165 (16,5 14,517,6, 145176 17,6 14,5-17,6) p0045 045 p=0,045 respectivamente 15,0 150 (15,0 14,117,8 141178 14,1 17,8 8 14,1-17,8 10,0 100 10 (10,0 8,512,4, 85124 8,5 12,4 4 8,5-12,4) p0048 048 p=0,048 CONCLUSÃO mentais associouse associou 2 p00 p>0,0 (p>0,05 14, (14, 014 11,014, 11014 110 11, 149 11,0-14, 17, (17, 616 14,616,7 14616 146 167 16, 14,6-16,7 p001 01 p=0,0 13, (13, 115 11,115, 11115 111 159 15, 11,1-15, (16, 517 14,517,6 14517 176 14,5-17,6 p004 04 p=0,04 (15, 117 14,117, 14117 141 178 14,1-17, 10, (10, 512 8,512,4 8512 85 8, 124 12, 8,5-12,4 p0 p>0, (p>0,0 (14 11,014 1101 11,0-14 (17 61 14,616, 1461 14,6-16, p=0, (13 11,115 1111 11,1-15 (16 51 14,517, 1451 14,5-17, (15 14,117 1411 14,1-17 (10 8,512, 851 8,5-12, p>0 (p>0, (1 11,01 11,0-1 14,616 14,6-16 p=0 11,11 11,1-1 14,517 14,5-17 14,11 14,1-1 8,512 8,5-12 p> (p>0 ( 11,0- 14,61 14,6-1 p= 11,1- 14,51 14,5-1 14,1- 8,51 8,5-1 (p> 14,6- 14,5- 8,5- (p

ABSTRACT BACKGROUND AND OBJECTIVES: Chronic pelvic pain (CPP) is a common condition in women and there are often associated comorbidities. The objective of this study was to evaluate the prevalence of comorbidities in patients with CPP and to seek associations between comorbidities and the manifestations of chronic pain. METHODS: Observational case-control study with sociodemographic, behavioral and clinical information, including comorbidities, in 246 women, 123 with CPP and 123 without CPP (control group). RESULTS: Anxiety, depression, migraine and endometriosis were the most frequent comorbidities in women with CPP. The comorbidities assessed in the CPP group were not associated with pain intensity score, history of abortion, physical violence or sexual violence (p>0.05). In the group of women with CPP and endometriosis, the median anxiety and depression score was significantly lower than in the group without endometriosis (14.5; 95% CI: 11.0-14.9) versus (17.0; 95% CI: 14.6-16.7), p=0.012 and (13.0; 95%CI: 11.1-15.9) versus (16.5; 95% CI: 14.5-17.6), p= 0.045, respectively. In patients with migraine, the median depression score was higher in the group of women with CPP compared to the group without CPP (15.0; 95% CI: 14.1-17.8) versus (10.0; 95% CI: 8.5-12.4), p=0.048. CONCLUSION: The most prevalent comorbidities in women with CPP were mental disorders, migraine and endometriosis. Comorbidities were not related to pain intensity, physical violence or sexual violence. Having a diagnosis of endometriosis is associated with lower anxiety and depression scores in patients with CPP. Overlapping migraine and CPP were associated with a worse depression score. OBJECTIVES (CPP METHODS casecontrol case control sociodemographic information 24 12 group. . group) RESULTS Anxiety abortion p>0.05. p005 p p>0.05 0 05 (p>0.05) 14.5 145 14 5 (14.5 95 CI 11.014.9 110149 11.0 14.9 11 9 11.0-14.9 17.0 170 17 (17.0 14.616.7, 146167 14.6 16.7 , 6 16 7 14.6-16.7) p0012 012 p=0.01 13.0 130 13 (13.0 95%CI 95CI 11.115.9 111159 11.1 15.9 1 15 11.1-15.9 16.5 165 (16.5 14.517.6, 145176 17.6 14.5-17.6) 0045 045 0.045 respectively 15.0 150 (15.0 14.117.8 141178 14.1 17.8 8 14.1-17.8 10.0 100 10 (10.0 8.512.4, 85124 8.5 12.4 4 8.5-12.4) p0048 048 p=0.048 CONCLUSION disorders 2 p00 p>0.0 (p>0.05 14. (14. 014 11.014. 11014 110 11. 149 11.0-14. 17. (17. 616 14.616.7 14616 146 167 16. 14.6-16.7 p001 01 p=0.0 13. (13. 115 11.115. 11115 111 159 15. 11.1-15. (16. 517 14.517.6 14517 176 14.5-17.6 004 04 0.04 (15. 117 14.117. 14117 141 178 14.1-17. 10. (10. 512 8.512.4 8512 85 8. 124 12. 8.5-12.4 p004 p=0.04 p0 p>0. (p>0.0 (14 11.014 1101 11.0-14 (17 61 14.616. 1461 14.6-16. p=0. (13 11.115 1111 11.1-15 (16 51 14.517. 1451 14.5-17. 00 0.0 (15 14.117 1411 14.1-17 (10 8.512. 851 8.5-12. p>0 (p>0. (1 11.01 11.0-1 14.616 14.6-16 p=0 11.11 11.1-1 14.517 14.5-17 0. 14.11 14.1-1 8.512 8.5-12 p> (p>0 ( 11.0- 14.61 14.6-1 11.1- 14.51 14.5-1 14.1- 8.51 8.5-1 (p> 14.6- 14.5- 8.5- (p

Resumo Este estudo teve por objetivo estimar parâmetros genéticos para características de Produção in vitro de Embriões - PIVE das raças Nelore e Senepol. Foram utilizados dados de 1.247 rodadas de fertilização in vitro (1.029 Nelore, 218 Senepol), no total de 148.311 oócitos (116.972 Nelore, 31.339 Senepol), 47.301 embriões (38.722 Nelore, 8.579 Senepol) e 6.323 prenhezes (5.534 Nelore e 789 Senepol). Foram analisadas as variáveis: porcentagem de oócitos viáveis (Pooc), porcentagem de embriões clivados (Pcliv); porcentagem de embriões produzidos (Pemb); porcentagem de prenhezes (Ppren) por rodada/touro; média de oócitos viáveis por doadora (MOD), média de embriões produzidos por doadora (MED) e média de prenhezes por doadora (MPD) de dados fornecidos por empresa parceira entre os anos de 2019 a 2022. Foi utilizado o programa SAS para análise dos efeitos fixos e Correlação Linear de Pearson. Os componentes de variância para cálculo das herdabilidades foram calculados por meio do programa MTDFREML Foram obtidos valores de MOD, MED e MPD para as raças Nelore de 29,94; 10,01; 2,53 e Senepol de 30,12; 8,17; 2,34. De modo geral, a raça Nelore proporcionou melhor produção de embriões em relação à raça Senepol. As estimativas de herdabilidades foram de baixa a média magnitude, sendo para Pcliv (0,16 e 0,04), Pemb (0,14 e 0,08), Ppren (0,02 e 0,15), MED (0,07 e 0,02) e MPD (0,05 e 0,00) para as raças Nelore e Senepol. Porém, indicando a presença de variabilidade genética e possibilidade de seleção. Conclui-se que há variabilidade genética para as características PIVE, para ambas as raças, indicando que podem ser utilizadas como critérios de seleção por serem herdáveis e que a raça Nelore apresenta melhor desempenho para as características de PIVE em relação à raça Senepol. 1247 1 247 1.24 1.029 1029 029 (1.02 21 Senepol, , 148311 148 311 148.31 116.972 116972 116 972 (116.97 31339 31 339 31.33 47301 47 301 47.30 38.722 38722 38 722 (38.72 8579 8 579 8.57 6323 6 323 6.32 5.534 5534 5 534 (5.53 78 . variáveis Pooc, Pooc (Pooc) (Pcliv) (Pemb) (Ppren rodada/touro rodadatouro rodada touro MOD (MOD) (MED (MPD 201 2022 Pearson 29,94 2994 29 94 10,01 1001 10 01 253 2 53 2,5 30,12 3012 30 12 8,17 817 17 234 34 2,34 geral magnitude 0,16 016 0 16 (0,1 0,04, 004 0,04 04 0,04) 0,14 014 14 0,08, 008 0,08 08 0,08) 0,02 002 02 (0,0 0,15, 015 0,15 15 0,15) 0,07 007 07 0,05 005 05 0,00 000 00 Porém Concluise Conclui se 124 24 1.2 1.02 102 (1.0 14831 148.3 116.97 11697 11 97 (116.9 3133 3 33 31.3 4730 4 47.3 38.72 3872 72 (38.7 857 57 8.5 632 32 6.3 5.53 553 (5.5 7 (Pooc (Pcliv (Pemb (MOD 20 202 29,9 299 9 10,0 100 25 2, 30,1 8,1 81 23 2,3 0,1 (0, 0,0 1. 1.0 (1. 1483 148. 116.9 1169 (116. 313 31. 473 47. 38.7 387 (38. 85 8. 63 6. 5.5 55 (5. 29, 10, 30, 8, 0, (0 (1 116. (116 38. (38 5. (5 ( (11 (3

Abstract This study aimed to estimate genetic parameters for traits of in vitro embryo production (IVEP) of Nellore and Senepol cattle. Data from 1,247 rounds of in vitro fertilization (1,029 Nellore, 218 Senepol) were used, totaling 148,311 oocytes (116,972 Nellore, 31,339 Senepol), 47,301 embryos (38,722 Nellore, 8,579 Senepol), and 6,323 pregnancies (5,534 Nellore, 789 Senepol). The variables percentage of viable oocytes (Pooc), percentage of cleaved embryos (Pcleav), percentage of produced embryos (Pemb), percentage of pregnancy (Ppreg) per round per bull, mean number of viable oocytes per donor (MOD), mean number of embryos produced per donor (MED), and mean number of pregnancies per donor (MPD) were analyzed from data provided by a partner company between the years 2019 and 2022. The SAS program was used to analyze fixed effects and Pearson linear correlation. The components of variance for heritabilities were calculated using the MTDFREML program. MOD, MED, and MPD values of 29.94, 10.01, and 2.53 were obtained for Nellore and 30.12, 8.17, and 2.34 for Senepol, respectively. In general, Nellore provided better embryo production compared to Senepol. Heritability estimates showed low to medium magnitude, with values Nellore and Senepol of 0.16 and 0.04 (Pcleav), 0.14 and 0.08 (Pemb), 0.02 and 0.15 (Ppreg), 0.07 and 0.02 (MED), and 0.05 and 0.00 (MPD), respectively. However, it indicates the presence of genetic variability and the possibility of selection. Therefore, there is genetic variability for IVEP traits in both breeds, indicating that they can be used as selection criteria because they are heritable and that Nellore presents better performance for IVEP traits compared to Senepol. (IVEP cattle 1247 1 247 1,24 1,029 1029 029 (1,02 21 148311 148 311 148,31 116,972 116972 116 972 (116,97 31339 31 339 31,33 , 47301 47 301 47,30 38,722 38722 38 722 (38,72 8579 8 579 8,57 6323 6 323 6,32 5,534 5534 5 534 (5,53 78 . Pooc, Pooc (Pooc) Pcleav, Pcleav (Pcleav) Pemb, Pemb (Pemb) Ppreg (Ppreg bull MOD (MOD) MED (MED) (MPD 201 2022 correlation 2994 29 94 29.94 1001 10 01 10.01 253 2 53 2.5 3012 30 12 30.12 817 17 8.17 234 34 2.3 respectively general magnitude 016 0 16 0.1 004 04 0.0 014 14 008 08 002 02 015 15 Ppreg, 007 07 005 05 000 00 MPD, However Therefore breeds 124 24 1,2 1,02 102 (1,0 14831 148,3 116,97 11697 11 97 (116,9 3133 3 33 31,3 4730 4 47,3 38,72 3872 72 (38,7 857 57 8,5 632 32 6,3 5,53 553 (5,5 7 (Pooc (Pcleav (Pemb (MOD (MED 20 202 299 9 29.9 100 10.0 25 2. 30.1 81 8.1 23 0. 1, 1,0 (1, 1483 148, 116,9 1169 (116, 313 31, 473 47, 38,7 387 (38, 85 8, 63 6, 5,5 55 (5, 29. 10. 30. 8. (1 116, (116 38, (38 5, (5 ( (11 (3

RESUMO Objetivo: comparar os níveis de capital cultural herdado da família entre egressos cotistas e não cotistas das universidades federais brasileiras e analisar a sua influência sobre a ocupação e remuneração dos egressos. Marco teórico: a literatura sociológica destaca que estudantes de famílias de baixa renda (como os cotistas) carecem de capital cultural herdado da família e isso pode afetar negativamente suas oportunidades no mercado de trabalho. Métodos: aplicamos um questionário eletrônico a 11.458 egressos, de 248 cursos de graduação e de 18 universidades federais brasileiras. Criamos os níveis de capital cultural dos egressos a partir de uma análise fatorial, realizada através de uma combinação de variáveis como escolaridade dos pais e frequência de consumo de bens culturais pelos estudantes antes de eles entrarem na universidade. Comparamos as médias obtidas de capital cultural entre egressos cotistas e não cotistas através do teste t de Student, e por meio da regressão logística multinomial, analisamos a influência desse capital cultural sobre a ocupação e remuneração dos egressos. Resultados: os resultados sugerem que egressos cotistas possuem menores níveis de capital cultural antes de entrarem na universidade federal do que os egressos não cotistas. No entanto, os resultados sugerem pouca influência desse capital cultural para ganhos ocupacionais e salariais no mercado de trabalho. Conclusões: os resultados destacam a relevância da política de cotas das universidades federais para a inclusão sociocultural e socioeconômica dos estudantes cotistas. Objetivo teórico trabalho Métodos 11458 11 458 11.45 24 1 fatorial Student multinomial Resultados entanto Conclusões 1145 45 11.4 2 114 4 11.

ABSTRACT Objective: compare the levels of cultural capital inherited from the family among quota and non-quota students from Brazilian federal universities and analyze its influence on the occupation and remuneration of graduates. Theoretical framework: the sociological literature points out that students from low-income families (such as quota holders) lack cultural capital inherited from the family and this can negatively affect their opportunities in the job market. Methods: we applied an electronic questionnaire to 11,458 graduates from 248 undergraduate courses and 18 Brazilian federal universities. We created the levels of cultural capital of graduates based on a factor analysis, carried out through a combination of variables such as parents’ education and frequency of consumption of cultural goods by students before entering university. We compared the averages obtained for cultural capital between quota and non-quota students through Student’s t-test, and through multinomial logistic regression, we analyzed the influence of this cultural capital on the occupation and remuneration of graduates. Results: the results suggest that quota student graduates have lower levels of cultural capital before entering the federal university than non-quota student graduates. However, the results suggest little influence of this cultural capital for occupational and salary gains in the labor market. Conclusions: the results highlight the relevance of the quota policy of federal universities for the sociocultural and socioeconomic inclusion of quota students. Objective nonquota non framework lowincome low income holders market Methods 11458 11 458 11,45 24 1 analysis parents Students Student s ttest, ttest t test, test t-test regression Results However Conclusions 1145 45 11,4 2 114 4 11,

ABSTRACT OBJECTIVE The transgender population in Brazil faces marginalization and difficulties in accessing education and health, leading many individuals to self-medicate. This study aimed to evaluate the impact of the implementation of Specialized Centers in the Transsexualizing Process (SCTP) on the use of cross-sex hormone therapy (CSHT) without medical prescription, as well as the level of education and mental health profile of these individuals. METHODS This is a cross-sectional study with data from physical and electronic medical records between September 2017 and February 2023 regarding the use of CSHT before and after the implementation of two SCTP in the state of Bahia, Brazil, in addition to data on education level, previous diagnosis of anxiety and depression of patients. RESULTS A total of 219 participants, 127 transgender men (TM) and 92 transgender women and travestis (TrTW), were assessed. A significant reduction in the prevalence of self-medication was observed in both TrTW (92.98% before and 51.43% after, p<0.001), and TM (47.17% before and 25.67% after, p = 0.010) with the implementation of SCTP. Transgender individuals who used CSHT before accessing the service were found to have a lower prevalence of depression. Self-medication was not significantly associated with education or anxiety in our sample. CONCLUSION The results indicate the need for the expansion of SCTP, as they were associated with lower rates of self-medication in the transgender population. selfmedicate. selfmedicate self medicate. medicate self-medicate (SCTP crosssex cross sex (CSHT prescription crosssectional sectional 201 202 Bahia patients 21 participants 12 (TM 9 TrTW, , (TrTW) assessed selfmedication medication 92.98% 9298 98 (92.98 5143 51 43 51.43 p<0.001, p0001 p<0.001 0 001 p<0.001) 47.17% 4717 47 17 (47.17 2567 25 67 25.67 0.010 0010 010 Selfmedication Self sample 20 2 1 (TrTW 92.98 929 (92.9 514 5 4 51.4 p000 p<0.00 00 47.17 471 (47.1 256 6 25.6 0.01 01 92.9 (92. 51. p00 p<0.0 47.1 (47. 25. 0.0 92. (92 p0 p<0. 47. (47 0. (9 p<0 (4 ( p<

Abstract Objective To develop a mobile application with a standardized routine, to be used by general otolaryngologists for evaluating patients with chronic rhinosinusitis. Methods A systematic review was made to identify outcomes, recommendations and what tests that would be used in the routine evaluation of patients with chronic rhinosinusitis; establish an expert consensus on items to be included in this routine evaluation of patients with chronic rhinosinusitis using the Delphi method; development of an application for use on a mobile device, with the routine evaluation of patients with chronic rhinosinusitis. Results Based on the systematic review, the outcomes used in studies about chronic rhinosinusitis were identified, as well as guidelines recommendations, which showed discrepancies between them. These recommendations and outcomes were presented to specialists in chronic rhinosinusitis, until a consensus was reached. As a result of the Delphi method, the flowchart of the routine evaluation of patients with chronic rhinosinusitis was defined, and then was used for the development of the mobile application. Conclusion The creation of the mobile application for evaluating patients with chronic rhinosinusitis followed an adequate methodology of elaboration made by specialists in the field of chronic rhinosinusitis, standardizing the investigation of these patients. Level of evidence: Level 5. method device identified them reached defined evidence 5

Abstract Thiosemicarbazones are promising classes of compounds with antitumor activity. For this study, six 2,4-dihydroxy-benzylidene-thiosemicarbazones compounds were synthesized. These compounds were submitted to different assays in silico, in vitro and in vivo to evaluate the toxicological, antioxidant and antitumor effects. The in silico results were evaluated by the SwissADME and pkCSM platforms and showed that all compounds had good oral bioavailability profiles. The in vitro and in vivo toxicity assays showed that the compounds showed low cytotoxicity against different normal cells and did not promote hemolytic effects. The single dose acute toxicity test (2000 mg/kg) showed that none of the compounds were toxic to mice. In in vitro antioxidant activity assays, the compounds showed moderate to low activity, with PB17 standing out for the ABTS radical capture assay. The in vivo antioxidant activity highlighted the compounds 1, 6 and 8 that promoted a significant increase in the concentration of liver antioxidant enzymes. Finally, all compounds showed promising antitumor activity against different cell lines, especially MCF-7 and DU145 lines, in addition, they inhibited the growth of sarcoma 180 at concentrations lower than 50 mg/kg. These results showed that the evaluated compounds can be considered as potential antitumor agents. study 2,4dihydroxybenzylidenethiosemicarbazones 24dihydroxybenzylidenethiosemicarbazones dihydroxybenzylidenethiosemicarbazones 2,4 dihydroxy benzylidene thiosemicarbazones 2 4 synthesized toxicological effects profiles 2000 (200 mg/kg mgkg mg kg mice PB PB1 assay 1 enzymes Finally lines MCF7 MCF 7 MCF- DU DU14 addition 18 5 agents 4dihydroxybenzylidenethiosemicarbazones 24 2, 200 (20 DU1 20 (2 (