Abstract Introduction As 30 to 50% of deep venous thrombosis (DVT) cases remain idiopathic, an increased focus on hematologic variables may therefore reveal novel correlates of DVT. Very few studies have investigated the association of hematological parameters with DVT and the causal relationship between them is still to be elucidated. Therefore, we aimed to investigate the association between serial values of hematologic variables and DVT. Methods Complete blood count parameters were serially measured at baseline and then at approximately 3-month intervals for 12 months in 152 adults with the first episode of DVT and 152 age- and sex-matched controls. The odds ratio (OR) with the 95% confidence interval (95%CI) was calculated as a measure of association between hematological parameters and DVT. Results The red cell distribution width (RDW) was the only hematologic variable which showed an independent and consistent association with DVT at all time points (multivariable-adjusted OR [95%CI] 3.38 [1.28 - 8.91] at baseline, 2.24 [0.85 - 5.92] at 3 months and 2.12 [0.81 - 5.55] at 12 months for RDW > 14.0%). This association was higher for provoked DVT than unprovoked DVT and for DVT plus pulmonary embolism than DVT alone. No significant correlation was found between the high RDW and classical thrombotic risk factors, except malignancy. Conclusions We demonstrated an independent and consistent association of the high RDW with the first episode of DVT in adult patients. The study was probably underpowered to evaluate the association between the high RDW and recurrent DVT. Further large studies with long follow-up are needed to confirm this association. 50 (DVT idiopathic elucidated Therefore 3month month 1 15 age sexmatched sex matched controls (OR 95 95%CI 95CI CI (95%CI (RDW multivariableadjusted multivariable adjusted [95%CI 338 38 3.3 1.28 128 28 [1.2 8.91 891 8 91 224 2 24 2.2 0.85 085 0 85 [0.8 5.92 592 5 92 212 2.1 0.81 081 81 5.55 555 55 14.0%. 140 14.0% . 14 14.0%) alone factors malignancy patients followup follow up 9 33 3. 1.2 [1. 8.9 89 22 2. 0.8 08 [0. 5.9 59 21 5.5 14.0 1. [1 8. 0. [0 5. 14. [

Abstract Introduction Cancer-associated thrombosis is a leading cause of morbidity and mortality in malignancy patients. Prophylactic anticoagulation is under-utilized and the cost of low-molecular-weight heparin (LMWH) and direct oral anticoagulants is a major barrier in developing countries. Material and methods A retrospective analysis was performed of all cancer-associated thrombosis patients attending the thrombosis clinic at a tertiary-level referral hospital based in North India between 2011 and 2015. Patient demographics and disease-related parameters were collected and analyzed. Results A total of 771 patients attended the thrombosis clinic during study period, of which 64 cases were malignancy-associated. Of these, 56% of the patients were female and 20% were bedridden. The median age was 48.5 years, adenocarcinoma (48%) being the most common histological subtype. Gynecological malignancies (30%) were the most common malignancies, followed by genitourinary (11%) malignancies. Most of the cases occurred during first year of diagnosis (51%), and only 14% occurred after 3 years. Most of the patients were on combined treatment. Almost 40% of the patients developed thrombosis within 30 days of surgical treatment. Lower limb thrombosis was the most commonly seen type (56%), while abdominal and pulmonary thrombosis were both seen in 5%. Patients were managed with LMWH and vitamin K antagonists (84.3%) and only 6.25% with LMWH alone. Direct oral anticoagulants were not commonly used during the study period. Discussion At the hospital studied, most of the cases occurred early in the disease course. Postoperative prophylaxis could have contributed towards reducing thrombosis in the peri-operative period. Early suspicion and prompt treatment can improve quality of life in such patients. Cancerassociated Cancer associated underutilized under utilized lowmolecularweight low molecular weight (LMWH countries cancerassociated cancer tertiarylevel tertiary level 201 2015 diseaserelated related analyzed 77 period 6 malignancyassociated. malignancyassociated associated. malignancy-associated these 56 20 bedridden 485 48 5 48. years 48% (48% subtype 30% (30% 11% 11 (11% 51%, 51 51% , (51%) 14 40 56%, (56%) 5% 84.3% 843 84 (84.3% 625 25 6.25 alone studied course perioperative peri operative 7 2 4 (48 (30 1 (11 (51% (56% 84.3 8 (84.3 62 6.2 (4 (3 (1 (51 (56 84. (84. 6. ( (5 (84 (8